CN113749752A - Flexible cryoablation probe - Google Patents
Flexible cryoablation probe Download PDFInfo
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- CN113749752A CN113749752A CN202111152555.4A CN202111152555A CN113749752A CN 113749752 A CN113749752 A CN 113749752A CN 202111152555 A CN202111152555 A CN 202111152555A CN 113749752 A CN113749752 A CN 113749752A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00541—Lung or bronchi
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00577—Ablation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
- A61B2018/0212—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques using an instrument inserted into a body lumen, e.g. catheter
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
- A61B2018/0231—Characteristics of handpieces or probes
- A61B2018/0237—Characteristics of handpieces or probes with a thermoelectric element in the probe for cooling purposes
- A61B2018/0243—Characteristics of handpieces or probes with a thermoelectric element in the probe for cooling purposes cooling of the hot side of the junction, e.g. heat sink
- A61B2018/025—Characteristics of handpieces or probes with a thermoelectric element in the probe for cooling purposes cooling of the hot side of the junction, e.g. heat sink by circulating liquid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
- A61B2018/0231—Characteristics of handpieces or probes
- A61B2018/0262—Characteristics of handpieces or probes using a circulating cryogenic fluid
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- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Engineering & Computer Science (AREA)
- Otolaryngology (AREA)
- Heart & Thoracic Surgery (AREA)
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- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Surgical Instruments (AREA)
Abstract
The invention discloses a flexible cryoablation probe, which belongs to the technical field of medical equipment and comprises a probe body, a handle part, a protective outer tube and a gas delivery pipe; the probe body is connected with the handle part; the handle part is connected with the protective outer tube; the probe body comprises a freezing probe, a throttle pipe, a medical plastic catheter, a temperature measuring thermocouple wire and a return pipe; the front end of the return pipe is connected with the freezing probe, the temperature thermocouple wire is wound on the outer surface of the return pipe in a spiral shape, and the outer surface of the temperature thermocouple wire is sleeved with a medical plastic conduit; a heat insulation interlayer is formed between the medical plastic conduit and the return pipe; the throttle pipe is arranged in the backflow pipe, the front end of the throttle pipe is close to the front end of the backflow pipe, and the rear end of the throttle pipe extends into the handle part; the gas pipe sets up in the protection outer tube inside to the gas pipe communicates with the choke pipe. The probe can realize the arrival of the whole lung of the lung cancer focus through the bronchus, has better safety and minimally invasive property, and can better realize the ablation treatment of the lung cancer.
Description
Technical Field
The invention relates to the technical field of medical equipment, in particular to a flexible cryoablation probe for lung cancer ablation treatment.
Background
Lung cancer is the first malignant tumor in both prevalence and fatality rate in China at present. Early discovery and early diagnosis of lung cancer are one of the fundamental strategies for improving the survival rate of lung cancer patients. Surgery and stereotactic radiotherapy are considered the first line of treatment for early stage lung cancer. However, some lung cancer patients cannot tolerate surgery or are not suitable for radiotherapy, so that interventional therapy becomes one of the important means for treatment. In recent years, bronchoscopic interventional pneumology technology and a pulmonary nodule accurate navigation system make great progress, ablation treatment of peripheral lung cancer/early lung cancer through the bronchoscope is gradually started, and the therapeutic effect is more exact particularly in patients with lung cancer diameter smaller than 2cm, so that the bronchoscopic interventional pneumology and pulmonary nodule accurate navigation system has a good application prospect; meanwhile, ablation treatment is carried out through a natural cavity, so that the risks of pneumothorax, hemorrhage and the like can be reduced.
Bronchoscopic peripheral lung cancer ablation techniques mainly include radiofrequency, microwave and cryotherapy. Cryoablation has several advantages over conventional radio frequency, microwave ablation. The radio frequency and the microwave are in an ellipsoid ablation range, and the cryoablation forms an approximate sphere which has better protection to blood vessels and nerves. In addition, the cryoablation has the function of relieving pain, and can reduce the pain and the complication in the operation compared with the traditional radio frequency and microwave ablation. The traditional cryoablation treatment is that the lung cancer focus is reached by percutaneous approach, and the risks of trauma, pneumothorax, skin frostbite and the like exist.
Disclosure of Invention
In order to solve the problem that the traditional lung cancer cryoablation treatment is that the lung cancer focus is reached by percutaneous approach, and the risk of wound, pneumothorax, skin frostbite and the like exists, the invention provides a flexible cryoablation probe for lung cancer ablation treatment, which comprises a probe body, a handle part, a protective outer tube and a gas delivery pipe; the probe body is connected with the handle part; the handle part is connected with the protective outer tube; the probe body comprises a freezing probe, a throttling pipe, a medical plastic catheter, a temperature measuring thermocouple wire and a return pipe; the front end of the backflow pipe is connected with the freezing probe, the temperature thermocouple wire is wound on the outer surface of the backflow pipe in a spiral shape, and the medical plastic catheter is sleeved on the outer surface of the temperature thermocouple wire; a heat insulation interlayer is formed between the medical plastic conduit and the return pipe; the throttle pipe is arranged in the return pipe, the front end of the throttle pipe is close to the front end of the return pipe, and the rear end of the throttle pipe extends into the handle part; the gas pipe is arranged inside the protective outer pipe and communicated with the throttle pipe.
Further, the handle part comprises a first handle shell, a second handle shell, a first reducing pipe, a handle vacuum interlayer inner layer pipe, a handle vacuum interlayer outer layer pipe, a heat exchanger, an electric heating wire, a second reducing pipe and a filter; one end of the first handle shell is connected with the probe body, and the other end of the first handle shell is connected with the second handle shell; the rear end of the return pipe penetrates through the first handle shell and then extends into the second handle shell; the first handle shell is connected with the handle vacuum interlayer inner layer pipe through the first reducing pipe, two ends of the handle vacuum interlayer outer layer pipe are connected with the handle vacuum interlayer inner layer pipe, and a handle vacuum interlayer is formed between the handle vacuum interlayer inner layer pipe and the handle vacuum interlayer outer layer pipe; the rear end of the throttle pipe is connected with an air outlet of the heat exchanger; the filter is arranged in the heat exchanger, the outlet of the filter is connected with the air outlet of the heat exchanger, the inlet of the filter is connected with the air inlet of the heat exchanger, and the air conveying pipe is connected with the air inlet of the heat exchanger; the electric heating wire is wound on an outer surface of the heat exchanger in a spiral shape; the handle vacuum interlayer inner-layer pipe is connected with the protection outer pipe through the second reducing pipe; the second handle shell is connected with the protective outer tube.
Preferably, the heat exchanger is a micro fin heat exchanger, and the material of the micro fin heat exchanger is red copper.
Preferably, the filter is a copper sintered filter, and the copper sintered filter is formed by sintering copper powder.
Preferably, the throttle pipe is a stainless steel capillary pipe with the inner diameter of 0.2mm-0.3 mm.
Preferably, the return pipe is a medical stainless steel capillary pipe with the diameter of 1mm-2mm and can be bent freely, and the medical stainless steel capillary pipe is softened by heat treatment.
Preferably, the temperature thermocouple wire is a T-shaped thermocouple wire.
Preferably, the gas transmission pipe is a metal capillary pipe.
Preferably, the material of the freezing probe is medical stainless steel; the medical plastic catheter is made of medical trifluoro or high molecular polyethylene.
Preferably, the first handle shell is made of silica gel; the second handle shell is made of ABS resin; the vacuum degree of the handle vacuum interlayer is 10-4Pa; the electric heating wire is a nickel-chromium, tungsten or carbon fiber heating wire; the first reducing is made of stainless steel; the second variable diameter is made of metal or plastic; the material of protection outer tube is silica gel or PVC.
The flexible cryoablation probe provided by the invention can reach the whole lung of a lung cancer focus through the probe body, the handle part, the protective outer tube and the gas delivery pipe and the bronchus, has better safety and micro-invasiveness, can better realize lung cancer ablation treatment by approximating the spherical ablation range, ensures the safe ablation range, and has good clinical application prospect.
Drawings
Fig. 1 is a schematic structural diagram of a flexible cryoablation probe according to an embodiment of the present invention.
Detailed Description
The technical solution of the present invention is further described below with reference to the accompanying drawings and examples.
The flexible cryoablation probe provided by the embodiment of the invention can meet the requirement of cryoablation treatment of lung cancer through a bronchoscope, so that the whole lung of a lung cancer focus can be reached, safe and efficient ablation treatment is realized, and a novel lung cancer interventional therapy technology is provided for medical clinic. Referring to fig. 1, the flexible cryoablation probe for lung cancer ablation therapy provided by the embodiment of the invention comprises a probe body, a handle part, a protective outer tube 16 and a gas delivery tube 17; the probe body is connected with the handle part; the handle part is connected with the protective outer tube 16; the probe body comprises a freezing probe 1, a throttle pipe 2, a medical plastic catheter 3, a temperature thermocouple wire 4 and a return pipe 5; the front end of the return pipe 5 is connected with the freezing probe 1, the temperature thermocouple wire 4 is wound on the outer surface of the return pipe 5 in a spiral shape, and the outer surface of the temperature thermocouple wire 4 is sleeved with the medical plastic catheter 3; a heat insulation interlayer is formed between the medical plastic conduit 3 and the return pipe 5; the throttle pipe 2 is arranged in the return pipe 5, the front end of the throttle pipe 2 is close to the front end of the return pipe 5, and the rear end of the throttle pipe 2 extends into the handle part; the air pipe 17 is arranged inside the protective outer pipe 16, and the air pipe 17 is communicated with the throttle pipe 2.
Referring to fig. 1, the handle part of the embodiment of the present invention further includes a first handle housing 6, a second handle housing 7, a first diameter-changing 8, a handle vacuum interlayer inner pipe 9, a handle vacuum interlayer outer pipe 10, a heat exchanger 12, an electric heating wire 13, a second diameter-changing 14, and a filter 15. Wherein, one end of the first handle shell 6 is connected with the probe body, and the other end of the first handle shell 6 is connected with the second handle shell 7; the rear end of the return pipe 5 passes through the first handle shell 6 and then extends into the second handle shell 7; the first handle shell 6 is connected with a handle vacuum interlayer inner layer pipe 9 through a first reducing 8, two ends of a handle vacuum interlayer outer layer pipe 10 are connected with the handle vacuum interlayer inner layer pipe 9, and a handle vacuum interlayer 11 is formed between the handle vacuum interlayer inner layer pipe 9 and the handle vacuum interlayer outer layer pipe 10; the rear end of the throttle pipe 2 is connected with the air outlet of the heat exchanger 12; a filter 15 is arranged in the heat exchanger 12, the outlet of the filter 15 is connected with the air outlet of the heat exchanger 12, the inlet of the filter 15 is connected with the air inlet of the heat exchanger 12, and an air conveying pipe 17 is connected with the air inlet of the heat exchanger 12; the electric heating wire 13 is wound on the outer surface of the heat exchanger 12 in a spiral shape; the handle vacuum interlayer inner layer pipe 9 is connected with the protection outer pipe 16 through a second reducing pipe 14; the second handle housing 7 is connected to a protective outer tube 16.
In practical applications, the heat exchanger 12 may be a micro-fin heat exchanger for exchanging heat between the air flowing through the interior and the exterior of the heat exchanger, and the micro-fin heat exchanger is made of red copper; the filter 15 is a copper sintered filter, the copper sintered filter is formed by sintering copper powder, the copper sintered filter is used for filtering micro particles in gas and preventing the throttling pipe 2 from being blocked, and meanwhile, the copper material has high heat conductivity coefficient and micro pores, so that the gas heat exchange efficiency can be effectively improved; the throttle pipe 2 is a pipe with an inner diameter of 0.2mm-0.3mmThe stainless steel capillary is used for jetting high-pressure gas (high-pressure argon or high-pressure helium) during working; the freezing probe 1 is a cryoablation area, and the material of the freezing probe 1 is medical stainless steel; the medical plastic catheter 3 is made of low temperature resistant material, such as medical trifluoro or high molecular polyethylene; the temperature measuring thermocouple wire 4 is a T-shaped thermocouple wire and is used for measuring the temperature of the freezing probe 1 and supporting the medical plastic conduit 3, so that a heat insulation interlayer is formed between the medical plastic conduit 3 and the return pipe 5; the return pipe 5 is a medical stainless steel capillary pipe which is softened by heat treatment and has the diameter of 1mm-2mm, and can be bent freely; the first handle shell 6 is made of silica gel; the second handle shell 7 is made of ABS resin; the vacuum degree of the handle vacuum interlayer 11 is 10-4Pa, which is used for playing a role of heat insulation; the electric heating wire 13 is a nickel-chromium, tungsten or carbon fiber heating wire and is used for heating the heat exchanger 12 so as to improve the temperature rising speed and save helium; the first reducing pipe 8 is made of stainless steel and is used for welding the sealed backflow pipe 5 and the handle vacuum interlayer inner-layer pipe 9 and fixing the first handle shell 6 and the second handle shell 7; the second reducing pipe 14 is made of metal or plastic and is used for fixing the second handle shell 7 and the protective outer pipe 16; the protective outer tube 16 is made of silica gel or PVC; the gas pipe 17 is a metal capillary tube, and is welded to the heat exchanger 12.
Referring to fig. 1, the flexible cryoablation probe according to the embodiment of the present invention needs to be used with a bronchoscope, and the probe is inserted along a working hole of the bronchoscope, and reaches a target tumor position of a bronchus through the bronchoscope, to start cryoablation therapy, and the specific process is as follows:
1. a freezing mode: high-pressure argon enters an inner hole of the heat exchanger 12 through a gas conveying pipe 17, enters the throttle pipe 2 through a filter 15 (a solid arrow in figure 1), is sprayed out from a port of the throttle pipe 2 and is changed into low-pressure argon, and meanwhile, the argon is cooled due to the Joule Thomson principle; the low-pressure low-temperature argon flows back to the outer fins of the heat exchanger 12 through a channel between the return pipe 5 and the throttle pipe 2, spirally flows out to a position between the protective outer pipe 16 and the gas conveying pipe 17 along the fins, and then is discharged into the atmosphere (hollow arrows in fig. 1); when low-temperature low-pressure argon flows through fins of the heat exchanger 12, precooling high-pressure argon newly flowing into an inner tube of the heat exchanger 12 through a heat exchange structure, ejecting the precooled high-pressure argon through a port of the throttle pipe 2 so as to further cool, and continuously cooling in such a circulating way until the boiling point of the liquid argon is reached; because the reflux gas has certain resistance when passing through the heat exchanger 12, the pressure of the reflux low-pressure argon is about 1-2MPa, so the lowest temperature of the freezing probe 1 is about-150 ℃; the heat insulation interlayer between the medical plastic catheter 3 and the return pipe 5 is supported by the temperature measuring thermocouple wire 4, so that the heat insulation effect is achieved, the frostbite is prevented, the utilization rate of cold energy is improved, and the cold energy is completely concentrated in the freezing working area of the freezing probe 1.
2. Heating mode: high-pressure helium flows into an inner hole of the heat exchanger 12 through a gas conveying pipe 17, then enters the throttle pipe 2 through the filter 15, is sprayed out from the port of the throttle pipe 2 and becomes low-pressure helium, and meanwhile, the helium is heated due to the Joule Thomson principle; the low-pressure high-temperature helium gas flows back to the fins on the outer side of the heat exchanger 12 through a channel between the return pipe 5 and the throttle pipe 2, flows out to a position between the protective outer pipe 16 and the gas conveying pipe 17 along the fins in a spiral mode, and is then discharged into the atmosphere; when the low-pressure high-temperature helium gas flows through the fins of the heat exchanger 12, the high-pressure helium gas which flows in the inner tube of the heat exchanger 12 is preheated through the heat exchange structure, and the preheated high-pressure helium gas is ejected through the port of the throttle pipe 2, so that the temperature is further raised, and the circulating temperature is continuously raised. However, since the price of helium is high, and a doctor wants to rapidly heat up, the electric heating wire 13 is wound on the root of the fin of the heat exchanger 12, and when the heating mode is started, the heat exchanger 12 is heated by supplying electricity to the electric heating wire 13 to heat up, so that the probe can be heated from 150 ℃ below zero to 0 ℃ within a few seconds under the dual actions of electric heating and helium throttling heating, thawing is realized, the probe is separated from a target tissue, and helium is saved.
The flexible cryoablation probe provided by the embodiment of the invention can meet the requirement of the bronchoscope lung cancer cryoablation treatment, and the flexible cryoablation probe reaches the lung cancer focus under the guidance of a navigation system or the guidance and positioning of an image through a bronchoscope working channel to form an approximately spherical ablation range with the central temperature of-150 ℃. The flexible cryoablation probe provided by the embodiment of the invention has the outer diameter of only 1.5mm, has high focus accessibility, can reach 7-level or more bronchi, can reach the lung through the natural orifice, and performs lung cancer cryoablation; compared with percutaneous cryoablation, the risk of pneumothorax, hemorrhage, skin frostbite and the like is reduced. The outer diameter of the flexible cryoablation probe provided by the embodiment of the invention is only 1.5mm, the ablation range of a sphere can be formed more easily, and the flexible cryoablation probe has more advantages than the conventional radiofrequency and microwave ablation ellipsoid ablation range and has better protectiveness to blood vessels and nerves. In addition, the cryoablation has the function of relieving pain, and can reduce the occurrence of pain complications in the operation compared with the traditional radio frequency and microwave ablation. In clinical application, the flexible cryoablation probe provided by the embodiment of the invention can realize the full lung arrival of lung cancer lesions through the bronchus, has better safety and micro-invasiveness, can better realize the lung cancer ablation treatment by the approximately spherical ablation range, ensures the safe ablation range, and has good clinical application prospect.
The above-mentioned embodiments are intended to illustrate the objects, technical solutions and advantages of the present invention in further detail, and it should be understood that the above-mentioned embodiments are only exemplary embodiments of the present invention, and are not intended to limit the present invention, and any modifications, equivalents, improvements and the like made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. A flexible cryoablation probe is characterized by comprising a probe body, a handle part, a protective outer tube and a gas delivery pipe; the probe body is connected with the handle part; the handle part is connected with the protective outer tube; the probe body comprises a freezing probe, a throttling pipe, a medical plastic catheter, a temperature measuring thermocouple wire and a return pipe; the front end of the backflow pipe is connected with the freezing probe, the temperature thermocouple wire is wound on the outer surface of the backflow pipe in a spiral shape, and the medical plastic catheter is sleeved on the outer surface of the temperature thermocouple wire; a heat insulation interlayer is formed between the medical plastic conduit and the return pipe; the throttle pipe is arranged in the return pipe, the front end of the throttle pipe is close to the front end of the return pipe, and the rear end of the throttle pipe extends into the handle part; the gas pipe is arranged inside the protective outer pipe and communicated with the throttle pipe.
2. The flexible cryoablation probe of claim 1, wherein the handle portion comprises a first handle shell, a second handle shell, a first diameter-changing, a handle vacuum interlayer inner tube, a handle vacuum interlayer outer tube, a heat exchanger, an electrical heater wire, a second diameter-changing, and a filter; one end of the first handle shell is connected with the probe body, and the other end of the first handle shell is connected with the second handle shell; the rear end of the return pipe penetrates through the first handle shell and then extends into the second handle shell; the first handle shell is connected with the handle vacuum interlayer inner layer pipe through the first reducing pipe, two ends of the handle vacuum interlayer outer layer pipe are connected with the handle vacuum interlayer inner layer pipe, and a handle vacuum interlayer is formed between the handle vacuum interlayer inner layer pipe and the handle vacuum interlayer outer layer pipe; the rear end of the throttle pipe is connected with an air outlet of the heat exchanger; the filter is arranged in the heat exchanger, the outlet of the filter is connected with the air outlet of the heat exchanger, the inlet of the filter is connected with the air inlet of the heat exchanger, and the air conveying pipe is connected with the air inlet of the heat exchanger; the electric heating wire is wound on an outer surface of the heat exchanger in a spiral shape; the handle vacuum interlayer inner-layer pipe is connected with the protection outer pipe through the second reducing pipe; the second handle shell is connected with the protective outer tube.
3. The flexible cryoablation probe of claim 2, wherein the heat exchanger is a micro-fin heat exchanger made of copper.
4. The flexible cryoablation probe of claim 2 wherein said filter is a copper sintered filter sintered from copper powder.
5. The flexible cryoablation probe of claim 2 wherein said throttle tube is a stainless steel capillary tube with an inner diameter of 0.2mm to 0.3 mm.
6. The flexible cryoablation probe of claim 2 wherein said return tube is a heat treated, softened, medical stainless steel capillary tube of 1mm to 2mm diameter and is freely bendable.
7. The flexible cryoablation probe of claim 2 wherein said thermometric thermocouple wire is a T-type thermocouple wire.
8. The flexible cryoablation probe of claim 2 wherein the gas delivery conduit is a metal capillary.
9. The flexible cryoablation probe of claim 2, wherein said cryoablation probe is made of medical stainless steel; the medical plastic catheter is made of medical trifluoro or high molecular polyethylene.
10. The flexible cryoablation probe of claim 2 wherein said first handle housing is formed of silicone; the second handle shell is made of ABS resin; the vacuum degree of the handle vacuum interlayer is 10-4Pa; the electric heating wire is a nickel-chromium, tungsten or carbon fiber heating wire; the first reducing is made of stainless steel; the second variable diameter is made of metal or plastic; the material of protection outer tube is silica gel or PVC.
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CN202111152555.4A CN113749752A (en) | 2021-09-29 | 2021-09-29 | Flexible cryoablation probe |
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CN202111152555.4A CN113749752A (en) | 2021-09-29 | 2021-09-29 | Flexible cryoablation probe |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN115998408A (en) * | 2023-03-24 | 2023-04-25 | 中日友好医院(中日友好临床医学研究所) | Cryoablation probe and surgical equipment for bronchovagal nerve blocking |
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2021
- 2021-09-29 CN CN202111152555.4A patent/CN113749752A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN115998408A (en) * | 2023-03-24 | 2023-04-25 | 中日友好医院(中日友好临床医学研究所) | Cryoablation probe and surgical equipment for bronchovagal nerve blocking |
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