CN109481001B - Cryogenic liquid type cryoablation equipment - Google Patents
Cryogenic liquid type cryoablation equipment Download PDFInfo
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- CN109481001B CN109481001B CN201811631346.6A CN201811631346A CN109481001B CN 109481001 B CN109481001 B CN 109481001B CN 201811631346 A CN201811631346 A CN 201811631346A CN 109481001 B CN109481001 B CN 109481001B
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- inlet pipe
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- heating component
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- 239000007788 liquid Substances 0.000 title claims abstract description 32
- 239000012530 fluid Substances 0.000 claims abstract description 88
- 238000010438 heat treatment Methods 0.000 claims abstract description 75
- 239000011248 coating agent Substances 0.000 claims description 15
- 238000000576 coating method Methods 0.000 claims description 15
- 238000009833 condensation Methods 0.000 claims description 9
- 230000005494 condensation Effects 0.000 claims description 6
- WYTGDNHDOZPMIW-RCBQFDQVSA-N alstonine Natural products C1=CC2=C3C=CC=CC3=NC2=C2N1C[C@H]1[C@H](C)OC=C(C(=O)OC)[C@H]1C2 WYTGDNHDOZPMIW-RCBQFDQVSA-N 0.000 claims description 2
- 239000002184 metal Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 7
- 238000007710 freezing Methods 0.000 abstract description 6
- 230000008014 freezing Effects 0.000 abstract description 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 29
- 229910052757 nitrogen Inorganic materials 0.000 description 14
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 7
- 239000000523 sample Substances 0.000 description 7
- 238000000034 method Methods 0.000 description 5
- 206010028980 Neoplasm Diseases 0.000 description 4
- 238000002679 ablation Methods 0.000 description 4
- 238000009529 body temperature measurement Methods 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 238000002681 cryosurgery Methods 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 2
- 230000001575 pathological effect Effects 0.000 description 2
- 239000003507 refrigerant Substances 0.000 description 2
- 238000005057 refrigeration Methods 0.000 description 2
- 230000000903 blocking effect Effects 0.000 description 1
- 210000005013 brain tissue Anatomy 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 239000002826 coolant Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 229910001873 dinitrogen Inorganic materials 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000009834 vaporization Methods 0.000 description 1
- 230000008016 vaporization Effects 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00696—Controlled or regulated parameters
- A61B2018/00714—Temperature
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
- A61B2018/0231—Characteristics of handpieces or probes
- A61B2018/0262—Characteristics of handpieces or probes using a circulating cryogenic fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
- A61B2018/0293—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques using an instrument interstitially inserted into the body, e.g. needle
Landscapes
- Health & Medical Sciences (AREA)
- Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Otolaryngology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Surgical Instruments (AREA)
Abstract
The invention provides low-temperature liquid type cryoablation equipment which comprises a host, a fluid conveying pipeline and a cryoablation needle, wherein the host comprises a cold source and a controller, the cryoablation needle comprises a handle and a cutter body connected with the handle, a one-way valve is arranged at the joint of the fluid conveying pipeline and the cryoablation needle, a heating assembly is arranged on a fluid inlet pipe behind the one-way valve, a temperature measuring couple is arranged in the fluid inlet pipe behind the heating assembly and close to the heating assembly, and the heating assembly and the temperature measuring couple are respectively connected with the host through wires. According to the low-temperature liquid type cryoablation device, the heating component is used for rapidly heating the low-temperature liquid into low-temperature gas or steam to be conveyed to the cutter head, so that the problem of air blockage of the low-temperature liquid on the conveying pipeline is avoided, a stable freezing effect can be achieved, and the treatment time is shortened.
Description
Technical Field
The invention belongs to the technical field of tumor ablation, and particularly relates to low-temperature liquid type cryoablation equipment.
Background
Cryosurgery is a method for destroying and ablating pathological tissues by using ultralow temperature, and is also the earliest pathological tissue ablation technology used in human history. After the probe-like liquid nitrogen freezer was invented by the american neurosurgeon Irving Cooper and the engineer Arnold Lee in 1960 and used to freeze brain tissue, a liquid nitrogen cryosurgery using liquid nitrogen as a cryogenic medium (coolant) was applied to treat various tumors.
Liquid nitrogen has the very desirable low temperature of-196 ℃ and the convenience available everywhere. When the probe is conveyed to the probe freezing area (target area) of the cryoprobe, heat can be quickly absorbed from tissues around the probe to generate vaporization, and a strong refrigeration effect is generated on the probe. However, liquid nitrogen can cause a "gas lock" effect when it blocks the tube by heating and gasifying before reaching the probe in the capillary transport tube. The air blocking effect will cause interruption of liquid nitrogen delivery, failure of liquid nitrogen to reach the probe freezing zone, and failure of cryosurgery.
Therefore, how to overcome the phenomenon of air blockage in the capillary tube conveying process or the use process of cooling the micro probe head by liquid nitrogen, and to manufacture a device with stable and reliable performance and good refrigeration effect is the key point of the research of the cryoablation instrument.
Disclosure of Invention
In view of the above, the present invention aims to provide a cryogenic liquid cryoablation apparatus, which ensures the temperature of surgical nitrogen gas without air blockage, can achieve better therapeutic effect and greatly shortens the treatment time.
In order to achieve the above purpose, the technical scheme of the invention is realized as follows:
the utility model provides a cryogenic liquid type cryoablation equipment, includes host computer, fluid delivery line and cryoablation needle, the host computer includes cold source and controller, the cryoablation needle includes the handle and the cutter body of being connected with the handle, fluid delivery line with cryoablation needle junction is equipped with the check valve, be equipped with heating element on the fluid income pipe behind the check valve, after the heating element and be close to heating element position department be equipped with the temperature measurement thermocouple in the fluid income pipe, heating element and temperature measurement thermocouple are connected with the host computer through the wire respectively.
Further, the heating component is arranged on a fluid inlet pipe outside the cryoablation needle or a fluid inlet pipe inside the cryoablation needle, and an insulating layer is arranged on the outer wall of the fluid inlet pipe contacted by the heating component.
Further, the heating component is arranged on a fluid inlet pipe in the handle of the cryoablation needle or on a fluid inlet pipe in the knife body of the cryoablation needle.
Further, the fluid inlet pipe inside the handle is of a self-condensation type pipe body structure and comprises an upper fluid inlet pipe section, a condensation section, a heating middle section and a lower fluid inlet pipe section which are sequentially communicated, wherein the condensation section is sleeved on the periphery of the lower fluid inlet pipe section and forms a sleeve type structure with two ends sealed with the pipe body of the lower fluid inlet pipe section, and a heating assembly is arranged on the pipe body with heating interruption.
Further, the heating component is a heating coil or a conductive coating.
Further, the heating component is a conductive coating which is coated on the outer wall of the fluid inlet pipe in the cutter bar, an insulating layer is arranged between the conductive coating and the outer wall of the fluid inlet pipe, one side, close to the cutter head of the cutter bar, of the conductive coating is connected with the wall of the fluid inlet pipe, and the distal end of the conductive coating and the distal end of the wall of the fluid inlet pipe are respectively connected with a wire and connected with a host through the wire; the fluid inlet pipe in the cutter bar is a conductive metal pipe.
Furthermore, the fluid inlet pipe in the cutter body is a serpentine condenser pipe, and a temperature measuring thermocouple is arranged at the cutter point.
Further, the controller comprises a control unit, a power supply, a display unit and an input unit; the power supply is electrically connected with the control unit, the heating component and the cold source; the control unit is electrically connected with the display unit, the heating component, the cold source, the input unit and the temperature measuring couple; the cold source is preferably liquid nitrogen, but can also be other liquid refrigerants with cooling effect, such as liquid ammonia or liquid oxygen.
Compared with the prior art, the low-temperature liquid type cryoablation device has the following advantages:
according to the low-temperature liquid type cryoablation device, the heating component is arranged on the fluid inlet pipe outside the cryoablation needle or the fluid inlet pipe inside the cryoablation needle, so that low-temperature liquid is quickly heated into low-temperature gas or steam to be conveyed to the cutter head, the problem of air blockage of the low-temperature liquid on the conveying pipeline is avoided, a stable freezing effect can be achieved, and the treatment time is shortened.
Drawings
The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the invention. In the drawings:
FIG. 1 is a schematic structural diagram of an embodiment of the present invention in which a host computer is connected to a cryoablation needle;
FIG. 2 is a schematic view of another embodiment of the connection of the main body and the cryoablation needle;
FIG. 3 is a schematic view showing the internal structure of the portion A of FIG. 2 in an implementation state according to the present invention;
FIG. 4 is a schematic view showing the internal structure of the second embodiment of the portion A of FIG. 2 according to the present invention;
FIG. 5 is a schematic view of the knife bar of the cryoablation needle b1 of FIGS. 3 and 4 in accordance with the present invention;
FIG. 6 is a schematic view showing the internal structure of the third embodiment of the portion A of FIG. 2 according to the present invention;
fig. 7 is a schematic view of the knife bar of the cryoablation needle of fig. 6 in accordance with the present invention.
Reference numerals illustrate:
1-cryoablation needle; 2-fluid inlet; 3-a heating assembly; 4-a one-way valve; 5-a main valve; 6-a host; 7-a fluid delivery line; 8-a temperature measurement couple; 11-fluid inlet inside the handle; 12-an air outlet pipe in the handle; 13-a cutter body; 14-a handle housing; 1101-upper section of fluid inlet tube; 1102-a condensing section; 1103-heating the middle section; 1104-lower section of fluid inlet tube; 31-heating wires.
Detailed Description
It should be noted that, without conflict, the embodiments of the present invention and features of the embodiments may be combined with each other.
In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc. indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, are merely for convenience in describing the present invention and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a specific orientation, be configured and operated in a specific orientation, and thus should not be construed as limiting the present invention. Furthermore, the terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first", "a second", etc. may explicitly or implicitly include one or more such feature. In the description of the present invention, unless otherwise indicated, the meaning of "a plurality" is two or more.
In the description of the present invention, it should be noted that, unless explicitly specified and limited otherwise, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be either fixedly connected, detachably connected, or integrally connected, for example; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present invention can be understood by those of ordinary skill in the art in a specific case.
The invention will be described in detail below with reference to the drawings in connection with embodiments.
The utility model provides a cryogenic liquid type cryoablation equipment, includes host computer 6, fluid delivery line 7 and cryoablation needle 1, host computer 6 includes cold source (preferably liquid nitrogen, also can be other liquid refrigerants that have the cooling effect, like liquid ammonia or liquid oxygen) and controller, is equipped with total valve 5 on the fluid delivery line 7, cryoablation needle 1 includes handle and the cutter body 13 of being connected with the handle, fluid delivery line 7 with cryoablation needle 1 junction is equipped with check valve 4, be equipped with heating element 3 on the fluid intake pipe 2 behind the check valve 4, be equipped with temperature thermocouple 8 in the fluid intake pipe 2 behind the heating element 3 and near heating element 3 position department, heating element 3 and temperature thermocouple 8 are connected with the host computer through the wire respectively. The controller comprises a control unit, a power supply, a display unit and an input unit; the power supply is electrically connected with the control unit, the heating component and the cold source; the control unit is electrically connected with the display unit, the heating component, the cold source, the input unit and the temperature measuring couple.
As shown in fig. 1, in one implementation, the heating element (heating coil in this embodiment) is disposed on the fluid inlet tube outside the cryoablation needle, and an insulating layer is disposed on the outer wall of the fluid inlet tube where the heating element contacts.
As another implementation state, as shown in fig. 2, the heating assembly is disposed on the fluid inlet tube inside the cryoablation needle, and the following two manners are provided: the heating assembly is provided on the fluid inlet tube inside the handle of the cryoablation needle (as shown in fig. 3-5) or on the fluid inlet tube inside the blade body of the cryoablation needle (as shown in fig. 6 and 7).
Example 1
In this embodiment, the heating component is disposed on the fluid inlet tube inside the cryoablation needle, specifically on the fluid inlet tube inside the handle of the cryoablation needle, and the connection structure between the host and the cryoablation needle is shown in fig. 2.
As shown in fig. 3 and 5, in this embodiment, the heating component 3 (preferably, a heating coil) is disposed in the fluid inlet pipe 11 inside the handle, the fluid inlet pipe 11 inside the handle is a single pipe, an insulating layer is disposed on the outer wall of the pipe, a circle of heating coil is wound around the outer side of the insulating layer, and two ends of the heating coil are electrically connected with the host through heating wires.
The specific working process is as follows: the power supply is switched on, the control unit controls the cold source and the main valve to enable liquid (liquid nitrogen in the embodiment) in the cold source to enter the fluid conveying pipeline 7, and further enter the fluid inlet pipe and the cryoablation needle through the one-way valve to perform tumor ablation; when liquid nitrogen enters the fluid inlet pipe inside the cryoablation needle through the one-way valve, the control unit controls the heating coil to heat the fluid inlet pipe inside the cryoablation needle, meanwhile, the temperature measuring couple continuously feeds back temperature information to the control unit, and the control unit continuously controls and adjusts the heating power of the heating coil according to the fed back information and the input information of the input unit, so that supercooled nitrogen or liquid nitrogen mixed gas meeting the freezing requirement of the operation is obtained and conveyed to the cutter body.
Example 2
In this embodiment, the heating component is disposed on the fluid inlet tube inside the cryoablation needle, specifically on the fluid inlet tube inside the handle of the cryoablation needle, and the connection structure between the host and the cryoablation needle is shown in fig. 2.
As shown in fig. 4 and 5, in this embodiment, the heating component (i.e. the heating coil) is disposed on the fluid inlet pipe 2 in the handle for heating, unlike in embodiment 1, the fluid inlet pipe in the handle is of a self-condensation type pipe body structure, and includes an upper fluid inlet pipe section 1101, a condensation section 1102, a middle heating section 1103 and a lower fluid inlet pipe section 1104 that are sequentially connected, where the condensation section 1102 is disposed around the lower fluid inlet pipe section 1104 and forms a sleeve structure with two sealed ends with the pipe body of the lower fluid inlet pipe section 1104, the pipe body of the heating interruption 1103 is provided with a heating component 3, an insulating layer is disposed between the heating component 3 and the outer wall of the pipe body of the heating interruption 1103, and two ends of the heating component 3 are electrically connected with the host through wires.
The specific working process is as follows: the power supply is switched on, the control unit controls the cold source and the main valve to enable liquid (liquid ammonia in the embodiment) in the cold source to enter the fluid conveying pipeline 7, and further enter the fluid inlet pipe and the cryoablation needle through the one-way valve to perform tumor ablation; when the liquid ammonia passes through the check valve and the fluid inlet pipe outside the cryoablation needle and then enters the fluid inlet pipe inside the cryoablation needle, the liquid ammonia flows through the upper section 1101 of the fluid inlet pipe and the condensing section 1102, and after the heating middle section 1103 is heated and pressurized to a set temperature, the liquid ammonia continuously enters the lower section 1104 of the fluid inlet pipe, is pre-cooled by the liquid ammonia which newly flows into the condensing section 1102, and then enters the cutter body for freezing operation.
Example 3
As shown in fig. 6 and 7, in this embodiment, the heating component is on the fluid inlet pipe in the cutter body 13, the heating component is a conductive coating, the conductive coating is coated on the outer wall of the fluid inlet pipe in the cutter body, an insulating layer is arranged between the conductive coating and the outer wall of the fluid inlet pipe, one side (1-2 cm away from the cutter tip) of the conductive coating, which is close to the cutter head on the cutter rod, is connected with the wall of the fluid inlet pipe, and the distal ends of the conductive coating and the distal end of the wall of the fluid inlet pipe are respectively connected with the heating wire 31 and are connected with the host through wires.
The foregoing description of the preferred embodiments of the invention is not intended to be limiting, but rather is intended to cover all modifications, equivalents, alternatives, and improvements that fall within the spirit and scope of the invention.
Claims (5)
1. The utility model provides a cryogenic liquid formula cryoablation equipment, includes host computer, fluid delivery line and cryoablation needle, the host computer includes cold source and controller, the cryoablation needle includes handle and the cutter body of being connected with the handle, its characterized in that: a one-way valve is arranged at the joint of the fluid conveying pipeline and the cryoablation needle, a heating component is arranged on a fluid inlet pipe behind the one-way valve, a temperature measuring thermocouple is arranged in the fluid inlet pipe behind the heating component and close to the heating component, and the heating component and the temperature measuring thermocouple are respectively connected with a host machine through wires;
the heating component is arranged on a fluid inlet pipe outside the cryoablation needle or a fluid inlet pipe inside the cryoablation needle, and an insulating layer is arranged on the outer wall of the fluid inlet pipe contacted by the heating component;
the heating component is arranged on a fluid inlet pipe in the handle of the cryoablation needle or on a fluid inlet pipe in the cutter body of the cryoablation needle;
the fluid inlet pipe inside the handle is of a self-condensation type pipe body structure and comprises a fluid inlet pipe upper section, a condensation section, a heating middle section and a fluid inlet pipe lower section which are communicated in sequence, wherein the condensation section is sleeved on the periphery of the fluid inlet pipe lower section and is in a sleeve type structure with two ends sealed with the pipe body of the fluid inlet pipe lower section, and a heating assembly is arranged on the pipe body with heating interruption.
2. The cryoablation apparatus of claim 1 wherein: the heating component is a heating coil or a conductive coating.
3. The cryoablation apparatus of claim 2 wherein: the heating component is a conductive coating which is coated on the outer wall of the fluid inlet pipe in the cutter bar, an insulating layer is arranged between the conductive coating and the outer wall of the fluid inlet pipe, one side of the conductive coating, which is close to the cutter head of the cutter bar, is connected with the wall of the fluid inlet pipe, and the distal end of the conductive coating and the distal end of the wall of the fluid inlet pipe are respectively connected with a wire and connected with a host through the wire; the fluid inlet pipe in the cutter bar is a conductive metal pipe.
4. The cryoablation apparatus of claim 1 wherein: the fluid inlet pipe in the cutter body is a serpentine condenser pipe, and a temperature measuring thermocouple is arranged at the cutter point.
5. The cryoablation apparatus of claim 1 wherein: the controller comprises a control unit, a power supply, a display unit and an input unit; the power supply is electrically connected with the control unit, the heating component and the cold source; the control unit is electrically connected with the display unit, the heating component, the cold source, the input unit and the temperature measuring couple.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811631346.6A CN109481001B (en) | 2018-12-29 | 2018-12-29 | Cryogenic liquid type cryoablation equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811631346.6A CN109481001B (en) | 2018-12-29 | 2018-12-29 | Cryogenic liquid type cryoablation equipment |
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| CN109481001A CN109481001A (en) | 2019-03-19 |
| CN109481001B true CN109481001B (en) | 2024-04-09 |
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| CN201811631346.6A Active CN109481001B (en) | 2018-12-29 | 2018-12-29 | Cryogenic liquid type cryoablation equipment |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113197660B (en) * | 2021-05-12 | 2022-12-09 | 上海导向医疗系统有限公司 | Control method and system of single-channel cryoablation device and cryoablation system |
| CN114636102B (en) * | 2021-06-30 | 2024-01-09 | 杭州堃博生物科技有限公司 | Working medium pressure control method for cryoablation |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN204797984U (en) * | 2015-06-02 | 2015-11-25 | 北京迈迪顶峰医疗科技有限公司 | Freezing system that melts |
| CN207693670U (en) * | 2017-06-12 | 2018-08-07 | 康沣生物科技(上海)有限公司 | A kind of electroded Cryoablation system |
| CN209751207U (en) * | 2018-12-29 | 2019-12-10 | 天津美电医疗科技有限公司 | Cryogenic liquid type cryoablation equipment |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7846154B2 (en) * | 2004-12-06 | 2010-12-07 | Galil Medical Ltd. | Gas-heated gas-cooled cryoprobe utilizing electrical heating and a single gas source |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN204797984U (en) * | 2015-06-02 | 2015-11-25 | 北京迈迪顶峰医疗科技有限公司 | Freezing system that melts |
| CN207693670U (en) * | 2017-06-12 | 2018-08-07 | 康沣生物科技(上海)有限公司 | A kind of electroded Cryoablation system |
| CN209751207U (en) * | 2018-12-29 | 2019-12-10 | 天津美电医疗科技有限公司 | Cryogenic liquid type cryoablation equipment |
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