CN113730643A - Antibacterial dressing and preparation method thereof - Google Patents
Antibacterial dressing and preparation method thereof Download PDFInfo
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- CN113730643A CN113730643A CN202111072358.1A CN202111072358A CN113730643A CN 113730643 A CN113730643 A CN 113730643A CN 202111072358 A CN202111072358 A CN 202111072358A CN 113730643 A CN113730643 A CN 113730643A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
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- D—TEXTILES; PAPER
- D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
- D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
- D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
- D04H1/40—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties
- D04H1/42—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties characterised by the use of certain kinds of fibres insofar as this use has no preponderant influence on the consolidation of the fleece
- D04H1/4382—Stretched reticular film fibres; Composite fibres; Mixed fibres; Ultrafine fibres; Fibres for artificial leather
- D04H1/43835—Mixed fibres, e.g. at least two chemically different fibres or fibre blends
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- D—TEXTILES; PAPER
- D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
- D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
- D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
- D04H1/40—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties
- D04H1/44—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties the fleeces or layers being consolidated by mechanical means, e.g. by rolling
- D04H1/46—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties the fleeces or layers being consolidated by mechanical means, e.g. by rolling by needling or like operations to cause entanglement of fibres
- D04H1/492—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties the fleeces or layers being consolidated by mechanical means, e.g. by rolling by needling or like operations to cause entanglement of fibres by fluid jet
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- D—TEXTILES; PAPER
- D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
- D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
- D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
- D04H1/40—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties
- D04H1/54—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties by welding together the fibres, e.g. by partially melting or dissolving
- D04H1/559—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties by welding together the fibres, e.g. by partially melting or dissolving the fibres being within layered webs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L2300/104—Silver, e.g. silver sulfadiazine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
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Abstract
The invention provides an antibacterial dressing and a preparation method thereof, and relates to the technical field of medical materials. In the invention, the antibacterial liquid beads are placed between the spunlace non-woven base fabric and the spunlace non-woven fabric surface layer and are broken under the stress condition, and a plurality of antibacterial liquid beads are placed between the spunlace non-woven base fabric and the spunlace non-woven fabric surface layer, so a certain number of antibacterial liquid beads can be crushed at certain time intervals according to the treatment requirement, the spunlace non-woven base fabric with strong hygroscopicity can be kept in a state of being soaked by the antibacterial liquid beads for a long time, and the spunlace non-woven base fabric is contacted with the skin, so that the skin infection germ part can be continuously sterilized, and the sterilization effect is good.
Description
Technical Field
The invention relates to the technical field of medical materials, in particular to an antibacterial dressing and a preparation method thereof.
Background
When the skin of a human body is infected with germs, symptoms such as pruritus, rash and the like can appear, and the skin has certain infectivity. At present, the following 2 methods are mainly used for treating skin pathogen infection: (1) the antibacterial ointment is applied to the affected part, and the mode has the advantages of high ointment drying speed and non-lasting drug effect; the antibacterial substance in the ointment is volatile to the surrounding environment; the pathogenic bacteria in the surrounding environment can not be prevented from contacting the affected part; the killing effect on germs is not ideal and the like; (2) the method has the advantages that the antibacterial substance cannot be completely concentrated on the affected part in the spraying process by using the antibacterial spraying to spray the affected part, so that the liquid medicine is wasted; the sprayed antibacterial substance has a faster drying speed than the applied antibacterial ointment and cannot produce a lasting curative effect; antibacterial substances are easy to be inhaled by a human body in the spraying process, so that respiratory tracts are stimulated, and discomfort is caused; the infected part of the germs in the surrounding environment can not be blocked; the killing effect on germs is not ideal, and the like.
Therefore, there is a need for an antimicrobial dressing that can continuously sterilize the skin infected with germs and can prevent germs in the surrounding environment from entering the affected part.
Disclosure of Invention
The antibacterial dressing provided by the invention can release antibacterial substances according to the needs of patients, continuously sterilize the parts of skin infected with germs, has a good sterilization effect, and can effectively prevent germs in the surrounding environment from entering the affected parts.
In order to achieve the above object, the present invention provides the following technical solutions:
the invention provides an antibacterial dressing, which comprises a spunlace non-woven base fabric and a spunlace non-woven fabric surface layer which are sequentially stacked; and a plurality of separated antibacterial liquid beads are arranged between the spunlace non-woven base fabric and the spunlace non-woven fabric surface layer.
Preferably, the spunlace nonwoven base fabric and the spunlace nonwoven fabric surface layer are bonded together at the positions without the antibacterial liquid beads.
Preferably, the antibacterial material in the antibacterial liquid bead comprises one or more of graphene, nano silver particles, nano gold particles, nano zinc particles, carbon nanotubes and metal alkene; the particle size of the antibacterial material is 50-100 nm.
Preferably, the diameter of the antibacterial liquid bead is 2-5 mm.
Preferably, the antibacterial beads are arranged in an array.
Preferably, the spunlace nonwoven base fabric is prepared by carrying out spunlace on tencel fibers and one of silkworm pupa protein fibers, milk protein fibers, pearl fibers and jade fibers.
Preferably, the spunlace nonwoven fabric surface layer is prepared by one of graphene polyester fiber, graphene nylon fiber and graphene acrylon and polypropylene fiber through spunlace.
The invention provides a preparation method of the antibacterial dressing in the technical scheme, which comprises the following steps:
mixing the sodium alginate solution and the antibacterial material to obtain an antibacterial sodium alginate solution;
dripping the antibacterial sodium alginate solution into an aqueous solution containing calcium ions, and standing to obtain antibacterial liquid beads;
and (3) separately placing a plurality of the antibacterial liquid beads on the spunlace non-woven base fabric, and then covering the spunlace non-woven fabric surface layer to obtain the antibacterial dressing.
Preferably, the spaced placement of the plurality of the antimicrobial beads on the spunlace nonwoven substrate comprises: and coating plant glue solution on the spunlace non-woven base fabric in a grid shape, placing the antibacterial liquid beads on the parts of the spunlace non-woven base fabric, which are not coated with the plant glue solution, and placing one antibacterial liquid bead on each grid.
Preferably, after covering the spunlace nonwoven fabric surface layer, pressing the part of the spunlace nonwoven fabric surface layer corresponding to the plant glue solution coated on the spunlace nonwoven base fabric by external pressure, and naturally drying to obtain the antibacterial dressing.
The invention provides an antibacterial dressing, which comprises a spunlace non-woven base fabric and a spunlace non-woven fabric surface layer which are sequentially stacked; and a plurality of separated antibacterial liquid beads are arranged between the spunlace non-woven base fabric and the spunlace non-woven fabric surface layer. In the invention, the antibacterial liquid beads are placed between the spunlace non-woven base fabric and the spunlace non-woven fabric surface layer and are broken under the stress condition, and a plurality of antibacterial liquid beads are placed between the spunlace non-woven base fabric and the spunlace non-woven fabric surface layer, so a certain number of antibacterial liquid beads can be crushed at certain time intervals according to the treatment requirement, the spunlace non-woven base fabric with stronger hygroscopicity can be kept in the state of being soaked by the antibacterial liquid beads for a long time, and the spunlace non-woven base fabric is contacted with the skin, so that the skin infection germ part can be continuously sterilized, and the sterilization effect is good.
Drawings
FIG. 1 is a schematic view of the construction of an antimicrobial dressing;
FIG. 2 is a schematic diagram showing the arrangement of plant gum solution and antibacterial beads;
in FIGS. 1-2, 1 is a spunlace nonwoven fabric facing; 2 is an antibacterial liquid bead; 3 is plant glue solution; 4 is spunlace non-woven base fabric.
Detailed Description
The invention provides an antibacterial dressing, which comprises a spunlace non-woven base fabric and a spunlace non-woven fabric surface layer which are sequentially stacked as shown in figure 1; and a plurality of separated antibacterial liquid beads are arranged between the spunlace non-woven base fabric and the spunlace non-woven fabric surface layer.
The antibacterial dressing provided by the invention comprises a spunlace non-woven base fabric and a spunlace non-woven fabric surface layer which are sequentially stacked. In the invention, the antibacterial dressing comprises a layer of spunlace non-woven base fabric and a layer of spunlace non-woven fabric surface layer which are sequentially arranged from bottom to top. In use, the spunlace nonwoven substrate contacts the skin.
In the invention, the spunlace non-woven base fabric is preferably prepared by spunlacing one of silkworm pupa protein fibers, milk protein fibers, pearl fibers and jade fibers and tencel fibers. In the invention, the silkworm pupa protein fiber and the milk protein fiber are rich in amino acid beneficial to human bodies; the pearl fiber is rich in pearl particles; the jade fiber is rich in jade particles, and has a caring effect on human skin; the tencel fiber has good hygroscopicity and silky touch; because the spunlace non-woven base fabric is prepared by mixing one of silkworm pupa protein fibers, milk protein fibers, pearl fibers and jade fibers with tencel fibers and then spunlacing the mixture, the spunlace non-woven base fabric has the advantages of skin friendliness, softness and moisture absorption, can promote the treatment of affected parts and has good use comfort.
In the invention, the mass fraction of the tencel fibers in the spunlace non-woven base fabric is preferably 40-60%.
The invention has no special requirements on the specific process of the spunlace, and the conventional spunlace process in the field can be adopted. In the invention, the gram weight of the spunlace non-woven base fabric is preferably 30-60 g/m2。
In the invention, the spunlace nonwoven fabric cover layer is preferably prepared by spunlace of polypropylene fiber and one of graphene polyester fiber, graphene nylon fiber and graphene acrylon. In the invention, the graphene polyester fiber, the graphene polyamide fiber and the graphene acrylic fiber have good antibacterial property and poor hygroscopicity, the official moisture regain of the polypropylene fiber is 0, the hygroscopicity is very poor, the spunlace nonwoven fabric surface layer is prepared by spunlacing the mixture of the graphene polyester fiber, the graphene polyamide fiber or the graphene acrylic fiber and the polypropylene fiber, so that the spunlace nonwoven fabric surface layer has antibacterial property, the contamination or infection of an affected part caused by the contact of germs in the surrounding environment with antibacterial liquid beads and the affected part can be avoided, the sterilization effect is ensured, meanwhile, the hygroscopicity of the graphene polyester fiber, the graphene polyamide fiber, the graphene acrylic fiber and the polypropylene fiber is poor, the absorbability of the spunlace nonwoven fabric surface layer to the antibacterial liquid beads is effectively reduced, the antibacterial liquid beads are ensured to be mainly absorbed by the spunlace nonwoven base fabric, and the utilization rate of the antibacterial liquid beads is improved, the sterilizing effect is good.
In the invention, the mass fraction of the polypropylene fiber in the spunlace nonwoven fabric surface layer is preferably 50-70%. The invention has no special requirements on the specific process of the spunlace, and the conventional spunlace process in the field can be adopted. In the invention, the gram weight of the spunlace non-woven fabric surface layer is preferably 25-50 g/m2。
The antibacterial dressing provided by the invention comprises antibacterial liquid beads arranged between the spunlace non-woven base fabric and the spunlace non-woven fabric surface layer; the quantity of antibiotic liquid pearl is a plurality of, and is a plurality of antibiotic liquid pearl separates the setting. In the present invention, the antibacterial beads are preferably arranged in an array. In the invention, the distance between adjacent antibacterial liquid beads is preferably 4-6 mm. In the invention, the diameter of the antibacterial liquid bead is preferably 1.5-5 mm, and more preferably 3-4 mm.
In the invention, the antibacterial material in the antibacterial liquid bead preferably comprises one or more of graphene, nano silver particles, nano gold particles, nano zinc particles, carbon nanotubes and metal alkene; the particle size of the antibacterial material is preferably 50-100 nm. In the present invention, the mass fraction of the antibacterial material in the antibacterial liquid bead is preferably 5% to 20%, and more preferably 8%.
In the invention, the parts without the antibacterial liquid beads between the spunlace nonwoven base fabric and the spunlace nonwoven fabric surface layer are preferably bonded together, so that the antibacterial liquid beads can be separated.
The invention also provides a preparation method of the antibacterial dressing in the technical scheme, which comprises the following steps:
mixing the sodium alginate solution and the antibacterial material to obtain an antibacterial sodium alginate solution;
dripping the antibacterial sodium alginate solution into an aqueous solution containing calcium ions, and standing to obtain antibacterial liquid beads;
and (3) separately placing a plurality of the antibacterial liquid beads on the spunlace non-woven base fabric, and then covering the spunlace non-woven fabric surface layer to obtain the antibacterial dressing.
According to the invention, the sodium alginate solution and the antibacterial material are mixed to obtain the antibacterial sodium alginate solution. In the invention, the concentration of the sodium alginate solution is preferably 1-5 wt%, and more preferably 3-4 wt%. In the present invention, the preparation method of the sodium alginate solution preferably comprises: adding sodium alginate into water, stirring to dissolve sodium alginate completely to obtain sodium alginate solution. In the present invention, the stirring is preferably performed at room temperature; the water is preferably purified water.
In the present invention, the composition of the antibacterial material is the same as that of the antibacterial material in the antibacterial liquid bead, and the description thereof is omitted.
In the invention, the mixing of the sodium alginate solution and the antibacterial material comprises the following steps: and adding the antibacterial material into the sodium alginate solution, and stirring to disperse the antibacterial material in the sodium alginate solution to obtain the antibacterial sodium alginate solution.
In the invention, the mass fraction of the antibacterial material in the antibacterial sodium alginate solution is preferably 0.1-5%, and more preferably 1-2%.
After the antibacterial sodium alginate solution is obtained, the antibacterial sodium alginate solution is dripped into an aqueous solution containing calcium ions and is kept stand to obtain the antibacterial liquid bead. In the present invention, the aqueous solution containing calcium ions includes a calcium chloride solution or a calcium lactate solution. In the present invention, the concentration of the aqueous solution containing calcium ions is preferably 5 to 10 wt%. In the present invention, the method for preparing the aqueous solution containing calcium ions preferably includes: adding calcium salt into water, stirring to dissolve calcium salt completely to obtain water solution containing calcium ions. In the present invention, the calcium salt preferably comprises calcium chloride or calcium lactate; the stirring is preferably carried out at room temperature; the water is preferably purified water.
In the invention, the dripping speed of the antibacterial sodium alginate solution into the aqueous solution containing calcium ions is preferably 0.5-1.5 seconds per drop, and more preferably 0.6-1 second per drop. The invention can avoid the adhesion of the antibacterial liquid beads caused by the excessively high dropping speed by controlling the dropping speed. In the embodiment of the invention, the antibacterial sodium alginate solution is dropped into the aqueous solution containing calcium ions by a syringe; the inner diameter of the injector is preferably 1-2 mm. The invention controls the size of the antibacterial liquid bead by controlling the inner diameter of the injector.
In the invention, the standing time is preferably 2-5 min, and more preferably 3-4 min. In the invention, after the antibacterial sodium alginate solution is dripped into the aqueous solution containing calcium ions, the surface of the antibacterial sodium alginate liquid drop and calcium chloride or calcium lactate are subjected to cross-linking reaction and form a film, and the solution in the antibacterial sodium alginate liquid drop is wrapped to form an antibacterial liquid bead.
In the invention, the surface layer of the antibacterial liquid bead is a membrane formed by crosslinking antibacterial sodium alginate and calcium ions, and the inner layer is an antibacterial sodium alginate solution.
After the antibacterial liquid beads are obtained, the antibacterial dressing is obtained by separately placing a plurality of antibacterial liquid beads on the spunlace non-woven base fabric and then covering the spunlace non-woven surface layer. In the present invention, the composition of the spunlace nonwoven base fabric and the spunlace nonwoven surface layer is described above and will not be described herein.
In the present invention, the spaced placement of the plurality of the antibacterial beads on the spunlace nonwoven substrate is preferably as shown in fig. 2, and comprises: and coating plant glue solution on the spunlace non-woven base fabric in a grid shape, placing the antibacterial liquid beads on the parts of the spunlace non-woven base fabric, which are not coated with the plant glue solution, and placing one antibacterial liquid bead on each grid. In the invention, the coating width of the plant glue solution is preferably 1-2 mm. In the invention, the grid is preferably a square grid, and the side length of the grid is preferably 6-8 mm.
In the invention, the plant glue solution is preferably one of guar gum solution, flax glue solution and cumin glue solution; the concentration of the plant glue solution is preferably 5-10 wt%; the solvent of the vegetable glue solution is preferably purified water.
According to the invention, after covering the spunlace non-woven fabric surface layer, the outer pressure is adopted to press the part of the spunlace non-woven fabric surface layer, which corresponds to the plant glue solution coated on the spunlace non-woven base fabric, and the plant glue solution is naturally dried to obtain the antibacterial dressing. In the present invention, the substance providing the external pressure is preferably a weight, more preferably a stainless steel rod; the diameter of the stainless steel rod is preferably the same as the width of the plant gum solution coated on the spunlace nonwoven base fabric.
The invention separates each antibacterial liquid bead by using the plant glue solution, and can tightly combine the spunlace non-woven base fabric and the spunlace non-woven fabric surface layer together, thereby improving the antibacterial effect of the dressing.
The preparation method is simple and strong in practicability, can release antibacterial substances according to the needs of patients, continuously sterilize the parts of skin infected with germs, has a good sterilization effect, and can effectively prevent germs in the surrounding environment from contacting the affected parts.
The technical solution of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. It is to be understood that the described embodiments are merely exemplary of the invention, and not restrictive of the full scope of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
Adding sodium alginate into purified water at room temperature, and stirring to completely dissolve the sodium alginate to obtain a sodium alginate solution with a mass fraction of 3%;
adding nano silver particles with the particle size of 50nm into the sodium alginate solution, and stirring to disperse the nano silver particles in the sodium alginate solution to obtain an antibacterial sodium alginate solution; the mass fraction of the nano silver particles is 1%;
adding calcium chloride into purified water at room temperature, and stirring to completely dissolve the calcium chloride to obtain a calcium chloride solution with the mass fraction of 5%;
dripping the antibacterial sodium alginate solution into the calcium chloride solution by using an injector, wherein the inner diameter of a needle head of the injector is 2mm, and the dripping speed is 1 second/drop; standing for reaction for 3min to obtain antibacterial liquid beads; the diameter of the antibacterial liquid bead is 3-4 mm;
coating plant glue solution on a spunlace non-woven base fabric in a square grid shape, wherein the width of the plant glue solution is 2mm, the part which is not coated with the plant glue solution forms square grids on the spunlace non-woven base fabric, the side length of each square grid is 8mm, placing one antibacterial liquid bead in each grid, then covering a layer of spunlace non-woven fabric surface layer on the spunlace non-woven base fabric, pressing the part, corresponding to the plant glue solution coated on the spunlace non-woven base fabric, of the spunlace non-woven fabric surface layer by using a stainless steel bar with the diameter of 2mm, and naturally airing to obtain the antibacterial dressing, wherein the part is shown in figures 1-2.
The guar gum solution is guar gum solution, the mass fraction of the guar gum in the guar gum solution is 5%, and the solvent of the guar gum solution is purified water.
The water isThe spunlaced non-woven base fabric is prepared by mixing milk protein fibers and tencel fibers and then carrying out spunlacing, the mass fraction of the tencel fibers in the spunlaced non-woven base fabric is 40%, and the gram weight of the spunlaced non-woven base fabric is 60g/m2。
The spunlace nonwoven fabric surface layer is prepared by mixing graphene polyester fibers and polypropylene fibers and then spunlacing the mixture, the mass fraction of the polypropylene fibers in the spunlace nonwoven fabric surface layer is 50%, and the gram weight of the spunlace nonwoven fabric surface layer is 25g/m2。
Example 2
Adding sodium alginate into purified water at room temperature, and stirring to completely dissolve the sodium alginate to obtain a sodium alginate solution with a mass fraction of 3%;
adding nano zinc particles with the particle size of 50nm into the sodium alginate solution, and stirring to disperse the nano zinc particles in the sodium alginate solution to obtain an antibacterial sodium alginate solution; the mass fraction of the nano zinc particles is 2%;
adding calcium chloride into purified water at room temperature, and stirring to completely dissolve the calcium chloride to obtain a calcium chloride solution with the mass fraction of 5%;
dripping the antibacterial sodium alginate solution into the calcium chloride solution by using an injector, wherein the inner diameter of a needle head of the injector is 1mm, and the dripping speed is 0.6 s/drop; standing for reaction for 3min to obtain antibacterial liquid beads; the diameter of the antibacterial liquid bead is 1.5-2 mm;
coating plant glue solution on a spunlace non-woven base fabric in a square grid shape, wherein the width of the plant glue solution is 2mm, the part which is not coated with the plant glue solution forms square grids on the spunlace non-woven base fabric, the side length of each square grid is 6mm, placing one antibacterial liquid bead in each grid, then covering a layer of spunlace non-woven fabric surface layer on the spunlace non-woven base fabric, pressing the part, corresponding to the plant glue solution coated on the spunlace non-woven base fabric, of the spunlace non-woven fabric surface layer by using a stainless steel bar with the diameter of 2mm, and naturally airing to obtain the antibacterial dressing, wherein the part is shown in figures 1-2.
The guar gum solution is guar gum solution, the mass fraction of the guar gum in the guar gum solution is 5%, and the solvent of the guar gum solution is purified water.
The spunlace non-woven base fabric is prepared by mixing milk protein fibers and tencel fibers and then spunlacing the mixture, wherein the mass fraction of the tencel fibers in the spunlace non-woven base fabric is 40%, and the gram weight of the spunlace non-woven base fabric is 30g/m2。
The spunlace nonwoven fabric surface layer is prepared by mixing graphene polyester fibers and polypropylene fibers and then spunlacing the mixture, the mass fraction of the polypropylene fibers in the spunlace nonwoven fabric surface layer is 50%, and the gram weight of the spunlace nonwoven fabric surface layer is 25g/m2。
Example 3
Adding sodium alginate into purified water at room temperature, and stirring to completely dissolve the sodium alginate to obtain a sodium alginate solution with a mass fraction of 3%;
adding nano silver particles with the particle size of 50nm into the sodium alginate solution, and stirring to disperse the nano silver particles in the sodium alginate solution to obtain an antibacterial sodium alginate solution; the mass fraction of the nano silver particles is 2%;
adding calcium chloride into purified water at room temperature, and stirring to completely dissolve the calcium chloride to obtain a calcium chloride solution with the mass fraction of 5%;
dripping the antibacterial sodium alginate solution into the calcium chloride solution by using an injector, wherein the inner diameter of a needle head of the injector is 1mm, and the dripping speed is 0.6 s/drop; standing for reaction for 3min to obtain antibacterial liquid beads; the diameter of the antibacterial liquid bead is 1.5-2 mm;
coating plant glue solution on a spunlace non-woven base fabric in a square grid shape, wherein the width of the plant glue solution is 2mm, the part which is not coated with the plant glue solution forms square grids on the spunlace non-woven base fabric, the side length of each square grid is 6mm, placing one antibacterial liquid bead in each grid, then covering a layer of spunlace non-woven fabric surface layer on the spunlace non-woven base fabric, pressing the part, corresponding to the plant glue solution coated on the spunlace non-woven base fabric, of the spunlace non-woven fabric surface layer by using a stainless steel bar with the diameter of 2mm, and naturally airing to obtain the antibacterial dressing, wherein the part is shown in figures 1-2.
The guar gum solution is guar gum solution, the mass fraction of the guar gum in the guar gum solution is 5%, and the solvent of the guar gum solution is purified water.
The spunlace non-woven base fabric is prepared by mixing milk protein fibers and tencel fibers and then spunlacing the mixture, wherein the mass fraction of the tencel fibers in the spunlace non-woven base fabric is 60%, and the gram weight of the spunlace non-woven base fabric is 30g/m2。
The spunlace nonwoven fabric surface layer is prepared by mixing graphene polyester fibers and polypropylene fibers and then spunlacing the mixture, the mass fraction of the polypropylene fibers in the spunlace nonwoven fabric surface layer is 70%, and the gram weight of the spunlace nonwoven fabric surface layer is 50g/m2。
Comparative example 1
The preparation method is substantially the same as that of example 1 except that the preparation and addition of the antibacterial beads are omitted.
Test example 1
The antibacterial activity of the antibacterial agents in the examples 1-3 and the comparative example 1 is tested according to GB 15979-2002 sanitary Standard for Disposable sanitary articles, and the specific test procedure is as follows: firstly, crushing the antibacterial liquid beads in the embodiments 1-3 to enable the antibacterial sodium alginate solution to infiltrate the spunlace nonwoven base fabric, and then testing the antibacterial activity of the spunlace nonwoven base fabric according to GB 15979-; the antibacterial activity of the spunlace nonwoven fabric surface layer of the comparative example 1 and the antibacterial activity of the spunlace nonwoven fabric base fabric of the comparative example 1 are respectively tested according to GB 15979-2002 sanitary Standard for Disposable sanitary articles. Table 1 shows the test results.
TABLE 1 results of the bacteriostatic ratio test
According to the requirements of GB 15979-2002, the bacteriostasis rate of the antibacterial (or bacteriostatic) product on escherichia coli and staphylococcus aureus is required to be more than or equal to 50 percent (dissolubility) or more than 26 percent (non-dissolubility). As can be seen from Table 1, examples 1 to 3 all had better bacteriostatic properties; the spunlace nonwoven substrate of comparative example 1 was not bacteriostatic because it contained no antimicrobial substance; the spunlace nonwoven fabric surface layer of the comparative example 1 contains graphene polyester fibers, and the graphene has bacteriostasis, so the spunlace nonwoven fabric surface layer of the comparative example 1 has certain bacteriostasis effect, and although the bacteriostasis rate is lower than that of the embodiments 1-3, germs in the surrounding environment can be effectively prevented from entering the interior of the dressing.
Test example 2
According to GB/T24218.6 part 6 of the test method for textile nonwovens: absorbency measurement the liquid absorbency of the spunlaced nonwoven facing and the spunlaced nonwoven backing of examples 1-3 was measured. Table 2 shows the test results.
Table 2 liquid uptake test results
As can be seen from table 2, the liquid absorption amount of the spunlace nonwoven base fabrics of examples 1 to 3 is significantly higher than that of the spunlace nonwoven fabric surface layers of examples 1 to 3, because the hygroscopicity of the graphene polyester fibers and the polypropylene fibers is very poor, and the spunlace nonwoven fabric surface layers are prepared by mixing the graphene polyester fibers and the polypropylene fibers and then spunlacing, the liquid absorption amount is low, the absorbability of the spunlace nonwoven fabric surface layers to the antibacterial sodium alginate solution is effectively reduced, it is ensured that the antibacterial sodium alginate solution is mainly absorbed by the spunlace nonwoven base fabrics, and the spunlace nonwoven base fabrics with strong hygroscopicity can be permanently kept in a state of being soaked by the antibacterial sodium alginate solution, and can continuously sterilize the skin infection germ parts, and the sterilization effect is good.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.
Claims (10)
1. The antibacterial dressing is characterized by comprising a spunlace non-woven base fabric and a spunlace non-woven fabric surface layer which are sequentially stacked; and a plurality of separated antibacterial liquid beads are arranged between the spunlace non-woven base fabric and the spunlace non-woven fabric surface layer.
2. The antimicrobial dressing of claim 1, wherein the spunlace nonwoven substrate and the spunlace nonwoven facing layer are bonded together at locations where no antimicrobial beads are disposed.
3. The antimicrobial dressing of claim 1, wherein the antimicrobial material in the antimicrobial bead comprises one or more of graphene, nano-silver particles, nano-gold particles, nano-zinc particles, carbon nanotubes, and metal olefins; the particle size of the antibacterial material is 50-100 nm.
4. The antimicrobial dressing of claim 1 or 3, wherein the antimicrobial bead has a diameter of 2-5 mm.
5. The antimicrobial dressing of claim 1, wherein the antimicrobial beads are arranged in an array.
6. The antibacterial dressing of claim 1, wherein the spunlace nonwoven base fabric is prepared by spunlacing one of silkworm pupa protein fibers, milk protein fibers, pearl fibers and jade fibers and tencel fibers.
7. The antibacterial dressing of claim 1, wherein the spunlace nonwoven fabric surface layer is prepared by spunlacing one of graphene polyester fibers, graphene polyamide fibers and graphene acrylon and polypropylene fibers.
8. A method of manufacturing an antimicrobial dressing according to any one of claims 1 to 7, comprising the steps of:
mixing the sodium alginate solution and the antibacterial material to obtain an antibacterial sodium alginate solution;
dripping the antibacterial sodium alginate solution into an aqueous solution containing calcium ions, and standing to obtain antibacterial liquid beads;
and (3) separately placing a plurality of the antibacterial liquid beads on the spunlace non-woven base fabric, and then covering the spunlace non-woven fabric surface layer to obtain the antibacterial dressing.
9. The method of claim 8, wherein said depositing a plurality of said antimicrobial beads spaced apart on a spunlace nonwoven substrate comprises: and coating plant glue solution on the spunlace non-woven base fabric in a grid shape, placing the antibacterial liquid beads on the parts of the spunlace non-woven base fabric, which are not coated with the plant glue solution, and placing one antibacterial liquid bead on each grid.
10. The preparation method of claim 9, wherein after covering the spunlace nonwoven fabric surface layer, pressing the part of the spunlace nonwoven fabric surface layer corresponding to the plant glue solution coated on the spunlace nonwoven base fabric by external pressure, and naturally airing to obtain the antibacterial dressing.
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