CN113730434A - Surgical flushing fluid and preparation method thereof - Google Patents
Surgical flushing fluid and preparation method thereof Download PDFInfo
- Publication number
- CN113730434A CN113730434A CN202111240975.8A CN202111240975A CN113730434A CN 113730434 A CN113730434 A CN 113730434A CN 202111240975 A CN202111240975 A CN 202111240975A CN 113730434 A CN113730434 A CN 113730434A
- Authority
- CN
- China
- Prior art keywords
- carbon dioxide
- sodium chloride
- surgical
- hypochlorous acid
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000012530 fluid Substances 0.000 title claims abstract description 24
- 238000011010 flushing procedure Methods 0.000 title abstract description 9
- 238000002360 preparation method Methods 0.000 title description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 44
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims abstract description 38
- 239000011780 sodium chloride Substances 0.000 claims abstract description 22
- 229910002092 carbon dioxide Inorganic materials 0.000 claims abstract description 19
- 239000001569 carbon dioxide Substances 0.000 claims abstract description 19
- QWPPOHNGKGFGJK-UHFFFAOYSA-N hypochlorous acid Chemical compound ClO QWPPOHNGKGFGJK-UHFFFAOYSA-N 0.000 claims abstract description 19
- 239000011259 mixed solution Substances 0.000 claims abstract description 12
- 239000012153 distilled water Substances 0.000 claims abstract description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000013010 irrigating solution Substances 0.000 claims abstract description 7
- 239000000243 solution Substances 0.000 claims abstract description 6
- 238000000034 method Methods 0.000 claims description 2
- 208000010444 Acidosis Diseases 0.000 abstract description 3
- 230000007950 acidosis Effects 0.000 abstract description 3
- 208000026545 acidosis disease Diseases 0.000 abstract description 3
- 210000004877 mucosa Anatomy 0.000 abstract description 3
- 230000001954 sterilising effect Effects 0.000 abstract description 3
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 3
- 230000007794 irritation Effects 0.000 abstract 1
- 238000005303 weighing Methods 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 230000002262 irrigation Effects 0.000 description 2
- 238000003973 irrigation Methods 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 230000004075 alteration Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/20—Elemental chlorine; Inorganic compounds releasing chlorine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Surgery (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a surgical flushing fluid, which comprises 0.7-1.1 mass percent of sodium chloride, 36-45ppm of hypochlorous acid and medical carbon dioxide; the pH value is adjusted to 5.6-5.8 by medical carbon dioxide. In preparing the above-described surgical irrigating fluid: (1) dissolving weighed sodium chloride in distilled water; (2) adding hypochlorous acid into the dissolved solution to obtain a mixed solution; (3) adding medical carbon dioxide into the mixed solution to adjust the pH until the pH is stabilized between 5.6-5.8, and obtaining the surgical irrigating solution. The operation flushing fluid has good stability and no irritation to skin and mucosa while ensuring the sterilization function, and can not cause imbalance of acid-base balance or acidosis of human body when used for operation flushing.
Description
Technical Field
The invention relates to the technical field of surgical flushing fluid, and particularly relates to surgical flushing fluid and a preparation method thereof.
Background
The operation refers to the treatment of excision, suture and the like of a patient body by a doctor with medical instruments. Aims to cure or diagnose diseases, such as removing pathological tissues, repairing injuries, transplanting organs, improving the functions and the forms of organisms and the like. The surgery may cause injury, bleeding, etc., and various complications may occur after the surgery.
However, some surgical irrigation fluids in the prior art have the problems of poor stability and easy cause of imbalance of acid-base balance of human bodies, and even some surgical irrigation fluids have toxic and side effects.
Disclosure of Invention
The invention provides a surgical washing fluid, which has good stability and no stimulation to skin and mucosa while ensuring the sterilization function, and can not cause imbalance of acid-base balance or acidosis of a human body when used for surgical washing.
The second technical problem to be solved by the present invention is to provide a method for preparing the above-mentioned surgical irrigating fluid.
In order to solve the technical problems, the technical scheme of the invention is as follows:
a surgical irrigating fluid comprises sodium chloride, distilled water, hypochlorous acid and medical carbon dioxide, wherein the mass percent of the sodium chloride is 0.7-1.1%, and the content of the hypochlorous acid is 36-45 ppm; the pH value is adjusted to 5.6-5.8 by medical carbon dioxide.
Preferably, the mass percentage of the sodium chloride is 0.9%.
Preferably, the hypochlorous acid content is 40 ppm.
The preparation method of the surgical irrigating fluid comprises the following steps:
(1) dissolving weighed sodium chloride in distilled water;
(2) adding hypochlorous acid into the dissolved solution to obtain a mixed solution;
(3) adding medical carbon dioxide into the mixed solution to adjust the pH until the pH is stabilized between 5.6-5.8, and obtaining the surgical irrigating solution.
The invention has the beneficial effects that:
the operation flushing fluid is prepared from sodium chloride, distilled water, hypochlorous acid and medical carbon dioxide, is weak in acidity as a whole, has no stimulation to skin and mucosa while ensuring the sterilization effect, and does not cause imbalance of acid-base balance or acidosis of a human body when being used for operation flushing.
The surgical irrigating fluid disclosed by the invention is simple and convenient in preparation method and flow, easy in obtaining of raw materials, low in overall manufacturing cost and suitable for popularization and application.
Detailed Description
The following examples further illustrate embodiments of the present invention. It should be noted that the description of the embodiments is provided to help understanding of the present invention, but the present invention is not limited thereto. In addition, the technical features involved in the embodiments of the present invention described below may be combined with each other as long as they do not conflict with each other.
Example 1
A surgical irrigating fluid comprises sodium chloride, distilled water, hypochlorous acid and medical carbon dioxide, wherein the mass percent of the sodium chloride is 0.9%, and the content of the hypochlorous acid is 40 ppm; the pH was adjusted to 5.7 by medical carbon dioxide.
When preparing the surgical irrigating fluid, firstly, weighing sodium chloride and dissolving the sodium chloride in distilled water; then adding hypochlorous acid into the dissolved solution to obtain a mixed solution; and finally, adding medical carbon dioxide into the mixed solution to adjust the pH until the pH is stabilized at 5.7, thus obtaining the surgical irrigating solution.
Example 2
A surgical irrigating fluid comprises sodium chloride, distilled water, hypochlorous acid and medical carbon dioxide, wherein the mass percent of the sodium chloride is 0.7%, and the content of the hypochlorous acid is 36 ppm; the pH was adjusted to 5.8 by medical carbon dioxide.
When preparing the surgical irrigating fluid, firstly, weighing sodium chloride and dissolving the sodium chloride in distilled water; then adding hypochlorous acid into the dissolved solution to obtain a mixed solution; and finally, adding medical carbon dioxide into the mixed solution to adjust the pH until the pH is stabilized to be 5.8, thus obtaining the surgical irrigating solution.
Example 3
A surgical irrigating fluid comprises sodium chloride, distilled water, hypochlorous acid and medical carbon dioxide, wherein the mass percent of the sodium chloride is 1.1%, and the content of the hypochlorous acid is 45 ppm; the pH was adjusted to 5.6 by medical carbon dioxide.
When preparing the surgical irrigating fluid, firstly, weighing sodium chloride and dissolving the sodium chloride in distilled water; then adding hypochlorous acid into the dissolved solution to obtain a mixed solution; and finally, adding medical carbon dioxide into the mixed solution to adjust the pH until the pH is stabilized to be 5.6, thus obtaining the surgical irrigating solution.
The embodiments of the present invention have been described in detail with reference to the examples, but the present invention is not limited to the described embodiments. It will be apparent to those skilled in the art that various changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, and the scope of protection is still within the scope of the invention.
Claims (4)
1. The surgical irrigating fluid is characterized by comprising 0.7-1.1 mass percent of sodium chloride, 36-45ppm of hypochlorous acid and medical carbon dioxide; the pH value is adjusted to 5.6-5.8 by medical carbon dioxide.
2. A surgical irrigating solution according to claim 1, wherein the sodium chloride is 0.9% by mass.
3. A surgical irrigating fluid according to claim 1, wherein the hypochlorous acid is present in an amount of 40 ppm.
4. A method of preparing a surgical irrigating fluid according to any of claims 1 to 3, which comprises the steps of:
(1) dissolving weighed sodium chloride in distilled water;
(2) adding hypochlorous acid into the dissolved solution to obtain a mixed solution;
(3) adding medical carbon dioxide into the mixed solution to adjust the pH until the pH is stabilized between 5.6-5.8, and obtaining the surgical irrigating solution.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111240975.8A CN113730434A (en) | 2021-10-25 | 2021-10-25 | Surgical flushing fluid and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111240975.8A CN113730434A (en) | 2021-10-25 | 2021-10-25 | Surgical flushing fluid and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113730434A true CN113730434A (en) | 2021-12-03 |
Family
ID=78727297
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111240975.8A Withdrawn CN113730434A (en) | 2021-10-25 | 2021-10-25 | Surgical flushing fluid and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113730434A (en) |
-
2021
- 2021-10-25 CN CN202111240975.8A patent/CN113730434A/en not_active Withdrawn
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20211203 |