CN113729716A - Magnetic-acoustic imaging device for brain of small animal - Google Patents
Magnetic-acoustic imaging device for brain of small animal Download PDFInfo
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- CN113729716A CN113729716A CN202111165317.7A CN202111165317A CN113729716A CN 113729716 A CN113729716 A CN 113729716A CN 202111165317 A CN202111165317 A CN 202111165317A CN 113729716 A CN113729716 A CN 113729716A
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- 238000003384 imaging method Methods 0.000 title claims abstract description 69
- 241001465754 Metazoa Species 0.000 title claims abstract description 43
- 210000004556 brain Anatomy 0.000 title claims abstract description 41
- 230000005284 excitation Effects 0.000 claims abstract description 46
- 238000012545 processing Methods 0.000 claims abstract description 28
- 230000003444 anaesthetic effect Effects 0.000 claims description 43
- 239000000523 sample Substances 0.000 claims description 31
- 238000001514 detection method Methods 0.000 claims description 15
- 238000002610 neuroimaging Methods 0.000 claims description 8
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- 238000011160 research Methods 0.000 description 4
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- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
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- 239000007822 coupling agent Substances 0.000 description 1
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- 229910052742 iron Inorganic materials 0.000 description 1
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- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/242—Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents
- A61B5/245—Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents specially adapted for magnetoencephalographic [MEG] signals
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- A61B8/0808—Detecting organic movements or changes, e.g. tumours, cysts, swellings for diagnosis of the brain
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Abstract
The embodiment of the invention discloses a magnetoacoustic imaging device for a brain of a small animal. The magneto-acoustic imaging apparatus includes: the side edge of the rotating platform is provided with a plurality of brackets; the fixed assembly is arranged on the rotary platform and used for fixing the object to be measured, and the object to be measured fixed on the fixed assembly is positioned in the stable magnetic field; a plurality of laser scanning radars; the signal excitation module is used for sending an electric signal to a target part of an object to be detected; the signal acquisition module is positioned above the fixed assembly, connected with the bracket and used for acquiring a magnetoacoustic signal excited by an electric signal at a target part of the object to be measured, and the laser scanning radar is also used for measuring the distance between the object to be measured and the signal acquisition module; and the signal processing module is used for receiving the magnetoacoustic signals and the distance and processing the magnetoacoustic signals according to the distance so as to obtain the depth model magnetoacoustic imaging of the object to be detected. The magnetoacoustic imaging device for the brains of the small animals, provided by the embodiment of the invention, can improve the magnetoacoustic imaging effect of the brains of the small animals.
Description
Technical Field
The embodiment of the invention relates to the imaging technology, in particular to a magnetoacoustic imaging device for a brain of a small animal.
Background
For the imaging research of biological tissues in medical science, magnetoacoustic imaging is used as functional imaging of non-invasive electrical characteristics based on magnetoacoustic effect, has the advantages of high sensitivity and high spatial resolution, and is widely applied to medical research. Magnetoacoustic imaging is mainly divided into a time domain and a frequency domain, and for the frequency domain magnetoacoustic imaging, continuous waves are generally used as excitation modes of magnetoacoustic imaging, so that the magnetoacoustic imaging has great potential in the aspects of early pathological diagnosis and biological tissue imaging.
At present, when the magnetoacoustic imaging device for the small animal brain uses continuous waves measured by a frequency domain to carry out magnetoacoustic imaging on an object to be measured, an adopted excitation signal is a low-frequency signal generally, a coupling agent does not need to be added, but the signal is large in attenuation amplitude in the air, the acquired low-frequency signal is the signal after attenuation, and the imaging effect obtained after processing is poor.
Disclosure of Invention
The embodiment of the invention provides a magnetoacoustic imaging device for a brain of a small animal, aiming at improving the magnetoacoustic imaging effect for the brain of the small animal.
The embodiment of the invention provides a magnetoacoustic imaging device for a brain of a small animal, which comprises:
the side edge of the rotating platform is provided with a plurality of brackets;
the fixed assembly is arranged on the rotary platform and used for fixing the object to be measured, and the object to be measured fixed on the fixed assembly is positioned in the stable magnetic field;
the laser scanning radars are fixed on the support and the fixing component and are used for scanning the object to be detected so as to determine the target part of the object to be detected;
the signal excitation module is arranged on the fixing component and used for sending an electric signal to a target part of the object to be detected;
the signal acquisition module is positioned above the fixed assembly, connected with the bracket and used for acquiring a magnetoacoustic signal excited by an electric signal at a target part of the object to be measured, and the laser scanning radar is also used for measuring the distance between the object to be measured and the signal acquisition module;
and the signal processing module is in communication connection with the laser scanning radar, is electrically connected with the signal excitation module and the signal acquisition module, is used for receiving the magnetoacoustic signals and the distance, and processes the magnetoacoustic signals according to the distance so as to obtain magnetoacoustic imaging of the object to be detected.
Optionally, the magnetoacoustic imaging device for a brain of a small animal further includes a static magnet, where the static magnet is located on the support and used for generating a magnetic field, so that the target portion of the object to be measured is excited to generate a magnetoacoustic signal by an electrical signal.
Optionally, the magnetoacoustic imaging device for the small animal brain further includes a controller and a driving motor, the signal processing module is integrated in the controller, the driving motor is electrically connected with the controller and the signal excitation module, and the controller is configured to control the driving motor to drive the signal excitation module to move to the target location according to the target location.
Optionally, the controller is further in communication connection with the laser scanning radar, and the controller is configured to receive a scanning result of the laser scanning radar and determine the target location according to the scanning result.
Optionally, the signal excitation module includes a pin electrode, the driving motor is electrically connected to the pin electrode, and the controller is configured to control the driving motor to drive the pin electrode to move to the target location.
Optionally, the signal acquisition module includes a detection electrode, the detection electrode is electrically connected to the signal processing module, and the detection electrode is used for detecting an electrical signal.
Optionally, the magnetoacoustic imaging device for a small animal brain further comprises an anesthetic assembly, and the anesthetic assembly is arranged on the fixing assembly and used for providing anesthetic for the object to be tested.
Optionally, the anesthetic assembly includes an anesthetic storage container and an anesthetic pump, the anesthetic pump communicates with the anesthetic storage container, and the anesthetic pump is used for injecting anesthetic at regular time for the analyte.
Optionally, the fixing assembly includes a fixing table and a plurality of fixing portions, the object to be measured is located on the fixing table, and the plurality of fixing portions are used for fixing different portions of the object to be measured.
Optionally, the signal acquisition module includes an acoustic probe, and the acoustic probe is electrically connected to the signal processing module.
The magnetoacoustic imaging device for the brains of the small animals comprises a rotary platform, a fixing assembly, a plurality of laser scanning radars, a signal excitation module, a signal acquisition module and a signal processing module, wherein a plurality of supports are arranged on the side edge of the rotary platform; the fixing component is arranged on the rotary platform and used for fixing the object to be detected; the laser scanning radars are fixed on the support and the fixing component and are used for scanning the object to be detected so as to determine the target part of the object to be detected; the signal excitation module is arranged on the fixing component and used for sending an electric signal to a target part of an object to be detected; the signal acquisition module is positioned above the fixed assembly, connected with the bracket and used for acquiring a magnetoacoustic signal excited by an electric signal at a target part of an object to be detected, and the object to be detected is positioned in a stable magnetic field; the signal processing module is electrically connected with the laser scanning radar, the signal excitation module and the signal acquisition module and used for receiving the magnetoacoustic signals and processing the magnetoacoustic signals so as to obtain magnetoacoustic imaging of the object to be detected. According to the magnetoacoustic imaging device for the brains of the small animals, provided by the embodiment of the invention, the objects to be measured are scanned through the plurality of laser scanning radars, the distance between the objects to be measured and the signal acquisition module can be measured, the measurement error is small, the measurement result is reliable, when the electric signals sent by the signal excitation module are low-frequency signals, the attenuation degree of the low-frequency signals in the air can be determined according to the measured distance, and the attenuation degree is related to the distance, so that the size of the low-frequency signals before attenuation can be determined, the problem of poor imaging effect caused by the attenuation of the low-frequency signals in the air is solved, and the magnetoacoustic imaging effect is improved.
Drawings
FIG. 1 is a schematic structural diagram of a magnetoacoustic imaging apparatus for a brain of a small animal according to an embodiment of the present invention;
FIG. 2 is a block diagram of a part of the structure of a magnetoacoustic imaging device for the brain of a small animal according to an embodiment of the present invention;
FIG. 3 is a block diagram of the structure of part of another magnetoacoustic imaging device for the brain of a small animal according to an embodiment of the present invention;
FIG. 4 is a schematic diagram of a partial structure of a magnetoacoustic imaging apparatus for a brain of a small animal according to an embodiment of the present invention;
FIG. 5 is a flow chart of a controller controlling the drive motor and the sonic probe according to an embodiment of the present invention;
FIG. 6 is a schematic diagram of a partial structure of another magnetoacoustic small-animal brain imaging device provided by an embodiment of the invention;
fig. 7 is a schematic diagram of a partial structure of another magnetoacoustic small-animal brain imaging device provided by the embodiment of the invention.
Detailed Description
The present invention will be described in further detail with reference to the accompanying drawings and examples. It is to be understood that the specific embodiments described herein are merely illustrative of the invention and are not limiting of the invention. It should be further noted that, for the convenience of description, only some of the structures related to the present invention are shown in the drawings, not all of the structures.
Fig. 1 is a schematic structural diagram of a magnetoacoustic imaging apparatus for a brain of a small animal according to an embodiment of the present invention, and fig. 2 is a block structural diagram of a part of the magnetoacoustic imaging apparatus for a brain of a small animal according to an embodiment of the present invention. With reference to fig. 1 and 2, the present embodiment can be applied to imaging research on biological tissues, and the small animal brain magnetoacoustic imaging apparatus includes: the system comprises a rotary platform 10, a fixed component 20, a plurality of laser scanning radars 30, a signal excitation module 40, a signal acquisition module 50 and a signal processing module 60.
Wherein, a plurality of brackets 11 are arranged on the side of the rotary platform 10; the fixed assembly 20 is arranged on the rotating platform 10 and used for fixing an object to be measured, and the object to be measured fixed on the fixed assembly 20 is located in a stable magnetic field; a plurality of laser scanning radars 30 are fixed on the support 11 and the fixing component 20, and are used for scanning the object to be detected so as to determine the target part of the object to be detected; the signal excitation module 40 is arranged on the fixing component 20 and used for sending an electric signal to a target part of an object to be detected; the signal acquisition module 50 is positioned above the fixing assembly 20 and connected with the bracket 11, and is used for acquiring a magnetoacoustic signal excited by an electric signal at a target part of an object to be measured, and the laser scanning radar 30 is also used for measuring the distance between the object to be measured and the signal acquisition module 50; the signal processing module 60 is in communication connection with the laser scanning radar 30, electrically connected with the signal excitation module 40 and the signal acquisition module 50, and configured to receive the magnetoacoustic signal and the distance, and process the magnetoacoustic signal according to the distance to obtain magnetoacoustic imaging of the object to be measured.
Specifically, the object to be measured may be a small animal such as a mouse, and the fixing component 20 may fix the head of the small animal, and in general, the magnetic acoustic imaging device for the brain of the small animal performs magnetic acoustic imaging on the head of the small animal such as the mouse. The laser scanning radar 30 may also be a laser radar ranging sensor, which can measure the distance between the object to be measured and the signal acquisition module 50, and reduce the measurement error. The support 11 is movable, and a magnet such as a static magnet may be disposed on the support 11 so that the object to be measured is located in a stable magnetic field to excite a magnetoacoustic signal when the object to be measured is excited by an electrical signal. The determinand is fixed at fixed subassembly 20, when needing to obtain the magnetic acoustic formation of image of determinand, laser scanning radar 30 can scan the determinand and measure the distance between determinand and signal acquisition module 50, each laser scanning radar 30 position is different, and the laser scanning radar 30 scanning result of different positions is also different, and signal processing module 60 can integrate the host computer, and the host computer accomplishes the determinand such as the head scanning modeling of mouse according to the scanning result of each laser scanning radar 30 to confirm that the excitation site is the target site. The signal excitation module 40 sends an electrical signal, such as a low-frequency current signal, to the target portion of the object to be measured, and since the object to be measured is in a stable magnetic field, the current is subjected to lorentz force in the magnetic field, so that the target portion of the object to be measured is excited by the electrical signal to generate a magnetoacoustic signal. The signal acquisition module 50 above the fixed component 20 acquires magnetoacoustic signals, and because the low-frequency magnetoacoustic signals are attenuated in the air, the attenuation degree is related to the distance between the object to be detected and the signal acquisition module 50, therefore, the signal processing module 60 can determine the attenuation degree according to the distance between the object to be detected and the signal acquisition module 50, the signal processing module 60 receives the magnetoacoustic signals and the distance, determines original signals before the magnetoacoustic signals are attenuated according to the distance, and further processes the original signals to obtain two-dimensional magnetoacoustic imaging of the object to be detected.
The magnetoacoustic imaging device for the brain of the small animal provided by the embodiment comprises a rotary platform, a plurality of laser scanning radars, a signal excitation module, a signal acquisition module and a signal processing module, wherein a plurality of brackets are arranged on the side edge of the rotary platform; the fixing component is arranged on the rotary platform and used for fixing the object to be detected; the laser scanning radars are fixed on the support and the fixing component and are used for scanning the object to be detected so as to determine the target part of the object to be detected; the signal excitation module is arranged on the fixing component and used for sending an electric signal to a target part of an object to be detected; the signal acquisition module is positioned above the fixed assembly, connected with the bracket and used for acquiring a magnetoacoustic signal excited by an electric signal at a target part of an object to be detected, and the object to be detected is positioned in a stable magnetic field; the signal processing module is electrically connected with the laser scanning radar, the signal excitation module and the signal acquisition module and used for receiving the magnetoacoustic signals and processing the magnetoacoustic signals so as to obtain magnetoacoustic imaging of the object to be detected. The toy brain magnetic sound imaging device that this embodiment provided, scan the determinand and can measure the distance between determinand and the signal acquisition module through a plurality of laser scanning radars, measuring error is less, and measuring result is reliable, when the signal of telecommunication that signal excitation module sent is low frequency signal, can confirm the attenuation degree of low frequency signal in the air according to the measured distance, the attenuation degree is relevant with the distance, thereby can confirm the size before the low frequency signal attenuates, solve the low frequency signal and attenuate and lead to the poor problem of formation of image effect in the air, thereby improve the magnetic sound imaging effect.
Optionally, the magnetoacoustic imaging apparatus for a brain of a small animal further includes a static magnet (not shown in the figure), and the static magnet is located on the support 11 and is used for generating a magnetic field, so that the target portion of the object to be measured is excited to generate a magnetoacoustic signal by an electrical signal.
The magnetostatic iron can generate a stable magnetic field, so that the object to be detected is located in the stable magnetic field, the electric signals, such as current signals, sent to the target part of the object to be detected by the signal excitation module can be subjected to Lorentz force in the magnetic field, the target part of the object to be detected is excited to generate magnetoacoustic signals by the electric signals, and therefore the magnetoacoustic signals can be acquired by the signal acquisition module, and magnetoacoustic imaging is achieved according to the magnetoacoustic signals.
Fig. 3 is a block diagram of a partial structure of another magnetoacoustic imaging apparatus for a brain of a small animal according to an embodiment of the present invention, and referring to fig. 3, optionally, the magnetoacoustic imaging apparatus for a brain of a small animal further includes a controller 70 and a driving motor 80, the signal processing module 60 is integrated in the controller 70, the driving motor 80 is electrically connected to the controller 70 and the signal excitation module 40, and the controller 70 is configured to control the driving motor 80 to drive the signal excitation module 40 to move to a target region according to the target region.
The controller 70 may be integrated into the upper computer, and the controller 70 may control the driving motor 80 to drive the bracket 11 to move to drive the signal excitation module 40 to move to the excitation site according to the excitation site, i.e., the target site, so that the signal excitation module 40 may send an electrical signal to the excitation site. The magnetoacoustic imaging device for the small animal brain may further include a mechanical arm, the signal excitation module 40 may be located on the mechanical arm, and the driving motor 80 may drive the signal excitation module 40 to the excitation site through driving the mechanical arm, and a specific implementation manner may be set according to an actual situation, which is not limited herein.
Also, the drive motor 80 may be plural, and different drive motors 80 are used to drive different components. The magnetoacoustic imaging apparatus for the small animal brain may further comprise a cranial drill, wherein a drive motor 80 is used to drive the movement of the cranial drill. Taking a mouse as an example of the object to be measured, when the target position of the mouse is in the skull of the head of the mouse, the controller 70 controls the corresponding driving motor 80 to drive the skull drill, and the skull of the head of the mouse is ground through the skull drill, so that the specific position of the target position is determined. The target part can be a plurality of target parts so as to excite different positions of the head of the mouse, and the excitation results of different excitation positions can be favorably compared.
Optionally, the controller 70 is further communicatively connected to the laser scanning radar 30, and the controller 70 is configured to receive a scanning result of the laser scanning radar 30 and determine the target portion according to the scanning result.
Specifically, with reference to fig. 1 and 3, the scanning result of each laser scanning radar 30 can be transmitted to the controller 70, and the controller 70 completes scanning modeling of the head of the object to be measured, such as a mouse, according to the scanning result, so as to determine the excitation site of the head of the mouse, i.e., the target site. The specific implementation of scan modeling may refer to the existing scan modeling technology, and is not described herein again.
Optionally, the signal excitation module 40 includes a pin electrode, the driving motor 80 is electrically connected to the pin electrode, and the controller 70 is configured to control the driving motor 80 to drive the pin electrode to move to the target portion.
The signal excitation module 40 may be an excitation signal output electrode, and the pin electrode is a commonly used electrode when performing electrical signal excitation on the object to be detected, and may be convenient for sending an electrical signal to the target portion of the object to be detected, and with reference to fig. 1 and 3, only the controller 70 needs to control the driving motor 80 to drive the pin electrode to be inserted into the target portion of the object to be detected, so that the signal excitation on the target portion may be realized, and the simple and easy operation is realized.
Fig. 4 is a schematic diagram of a partial structure of a magnetoacoustic imaging apparatus for a brain of a small animal according to an embodiment of the present invention, and referring to fig. 4, optionally, the signal acquisition module 50 includes a detection electrode 51, the detection electrode 51 is electrically connected to the signal processing module 60, and the detection electrode 51 is used for detecting an electrical signal.
The position of the detecting electrode 51 is shown in fig. 4, the electrical signal detected by the detecting electrode 51 can be transmitted to the signal processing module 60, and the signal processing module 60 can perform corresponding analysis and research according to the electrical signal. The detection electrode 51 may be a contact pin type electrode, and the electric signal detected by the detection electrode 51 is the same as the acquisition position of the magnetoacoustic signal.
In addition, fig. 4 shows one laser scanning radar 30 located above the fixing component 20, fig. 1 shows two laser scanning radars 30 located on the support 11, and positions of the objects to be measured scanned by the respective laser scanning radars 30 are different, for example, by the laser scanning radars 30 arranged at different positions shown in fig. 1 and 4, scanning of different positions and directions of the head of the object to be measured, such as a mouse, can be realized, so as to complete three-dimensional modeling.
Optionally, the signal acquisition module 50 includes an acoustic probe 52, and the acoustic probe 52 is electrically connected to the signal processing module 60.
Specifically, referring to fig. 4, the acoustic probe 52 can acquire a magnetoacoustic signal excited by a target portion of an object to be measured, and the acoustic probe 52 is a transducer that converts electrical energy and acoustic energy by using a piezoelectric effect of a material. The acoustic probe 52 can be provided with a wafer, the wafer is a single crystal or polycrystal thin sheet with piezoelectric effect, electric energy and acoustic energy can be mutually converted, the mode of collecting signals by the acoustic probe 52 is simple and easy to operate, and the complexity of the magnetic acoustic imaging device for the brain of the small animal can be reduced.
In addition, for the magnetoacoustic imaging device of the small animal brain, a space coordinate system X-Y-Z is shown in figure 1. The magnetoacoustic imaging device for the small animal brain can further comprise a distance measuring module, the detection electrode 51 of the signal acquisition module 50, the acoustic probe 52 and the distance measuring module are integrated on the Z-axis rotating platform 12, downward detection, conversion and translation of the acoustic probe 52 are completed, the distance between the acoustic probe 52 and an object to be detected is measured through the distance measuring module, the position of the acoustic probe 52 and the position of the detection electrode 51 are adjusted through a driving motor 80, the acoustic probe 52 is ensured to be the same as the distance between the object to be detected and the distance between the object to be detected in different directions, the attenuation of acoustic signals is synchronized as much as possible, and meanwhile, the acquisition positions of the acoustic signals and electric signals are ensured to be the same. Wherein, the range finding module can be laser radar range sensor, as laser scanning radar 30 shown in fig. 4 promptly, uses laser radar range sensor to measure the determinand and the distance of sonic probe 52, if measure the position of determinand and the position of sonic probe 52 through laser radar range sensor, can be according to determinand the distance between them of determinand and sonic probe 52 position, can minimize measuring error.
In an implementation manner, fig. 5 is a flowchart illustrating that a controller controls a driving motor and an acoustic probe according to an embodiment of the present invention, and referring to fig. 3, fig. 4 and fig. 5, a process of controlling the driving motor 80, the acoustic probe 52 and the detection electrode 51 by the controller 70 specifically includes the following steps:
the method comprises the following steps: and acquiring the scanning range and the scanning interval of the laser scanning radar in the x direction and the y direction.
The x and y directions are x and y directions in the coordinate system shown in fig. 1, and the origin of the coordinate system may be specifically set according to the actual situation, which is not limited herein.
Step two: judging whether the driving motor completes n steps in the x direction; if yes, executing step fourteen; if not, executing step three.
Step three: and controlling the driving motor to advance in the x direction by n.
Step four: judging whether the driving motor completes m steps in the y direction; if yes, executing step twelve; if not, executing step five.
The step length of the driving motor and the specific values of m and n may be specifically set according to actual conditions, and are not limited herein.
Step five: and controlling the driving motor to advance m in the y direction.
Step six: and acquiring the height of the acoustic probe measured by the distance measuring sensor in the z direction.
Step seven: and controlling a driving motor to drive the acoustic probe to move to a height h1 and drive the detection electrode to move to a height h2, and acquiring the acquired data of the acoustic probe.
Step eight: and controlling the acoustic probe to rotate 90 degrees at the height h1 and move downwards by the height h1, and acquiring the acquired data of the acoustic probe.
Step nine: and controlling the acoustic probe to move upwards by a height h1 at the height h1 and rotate by 90 degrees, and acquiring the acquired data of the acoustic probe.
Step ten: and controlling the acoustic probe to move downwards at the height h1 by the height h2, and acquiring the acquired data of the acoustic probe.
Step ten: and controlling the acoustic probe to move upwards by a height h2 at the height h1 and rotate by 180 degrees, and acquiring the acquired data of the acoustic probe.
Step eleven: m is m + 1.
And the controller controls the step length of the motor to be increased by 1 and returns to the step four.
Step twelve: and controlling the driving motor to return to m steps in the y direction.
Step thirteen: n is n + 1.
And the controller controls the step length of the motor to be increased by 1 and returns to the step two.
Fourteen steps: and controlling the driving motor to return to n steps in the x direction.
Fig. 6 is a schematic diagram of a partial structure of another magnetoacoustic imaging apparatus for a brain of a small animal according to an embodiment of the present invention, and referring to fig. 6, optionally, an anesthetic assembly 90 is further included, and the anesthetic assembly 90 is disposed on the fixing assembly 20 and is used for providing anesthetic to an object to be tested.
The anesthetic assembly 90 can be electrically connected to the controller 70, and can automatically inject anesthetic into an object to be tested, such as a mouse, so that the mouse is in an anesthetic state, and the effect of magnetoacoustic imaging influenced by various reactions of the mouse in a waking state is prevented.
Optionally, the anesthetic assembly 90 includes an anesthetic storage container 91 and an anesthetic pump 92, the anesthetic pump being in communication with the anesthetic storage container, and the anesthetic pump being configured to inject an anesthetic at a predetermined time for the analyte.
Specifically, referring to fig. 6, anesthetic is stored in an anesthetic storage container 91, and an anesthetic injector, i.e., an anesthetic pump 92, can inject anesthetic for the subject at a predetermined time. If a plurality of driving motors 80 are provided, different driving motors 80 are used for driving different components, one driving motor 80 can drive the anesthetic pump 92 to inject anesthetic into the object to be tested, and the controller 70 can control the driving motor 80 at regular time, so that the anesthetic can be injected at regular time, that is, the anesthetic pump 92 can inject anesthetic into the object to be tested at regular intervals, so as to ensure the anesthetic effect.
Optionally, the fixing assembly 20 includes a fixing table 21 and a plurality of fixing portions 22, the object is located on the fixing table 21, and the plurality of fixing portions 22 are used for fixing different portions of the object.
Specifically, fig. 7 is a schematic diagram of a partial structure of another magnetic acoustic imaging apparatus for a brain of a small animal according to an embodiment of the present invention, and referring to fig. 6 and 7, taking an object to be measured as a mouse as an example, the plurality of fixing portions 22 may include a tooth fixing portion, a neck fixing portion and an ear fixing portion of the mouse, so as to fix the head of the mouse through the plurality of fixing portions 22, thereby facilitating scanning the head of the mouse and completing magnetic acoustic imaging.
The toy brain magnetic sound imaging device that this embodiment provided, scan the determinand and can measure the distance between determinand and the signal acquisition module through a plurality of laser scanning radars, measuring error is less, and measuring result is reliable, when the signal of telecommunication that signal excitation module sent is low frequency signal, can confirm the attenuation degree of low frequency signal in the air according to the measured distance, the attenuation degree is relevant with the distance, thereby can confirm the size before the low frequency signal attenuates, solve the low frequency signal and attenuate and lead to the poor problem of formation of image effect in the air, thereby improve the magnetic sound imaging effect.
It is to be noted that the foregoing is only illustrative of the preferred embodiments of the present invention and the technical principles employed. It will be understood by those skilled in the art that the present invention is not limited to the particular embodiments described herein, but is capable of various obvious modifications, rearrangements, combinations and substitutions as will now become apparent to those skilled in the art without departing from the scope of the invention. Therefore, although the present invention has been described in greater detail by the above embodiments, the present invention is not limited to the above embodiments, and may include other equivalent embodiments without departing from the spirit of the present invention, and the scope of the present invention is determined by the scope of the appended claims.
Claims (10)
1. A small animal brain magnetoacoustic imaging apparatus, comprising:
the side edge of the rotating platform is provided with a plurality of brackets;
the fixed assembly is arranged on the rotary platform and used for fixing an object to be measured, and the object to be measured fixed on the fixed assembly is positioned in a stable magnetic field;
the laser scanning radars are fixed on the support and the fixing component and are used for scanning the object to be detected so as to determine a target part of the object to be detected;
the signal excitation module is arranged on the fixing component and used for sending an electric signal to a target part of the object to be detected;
the signal acquisition module is positioned above the fixed assembly, connected with the bracket and used for acquiring a magnetoacoustic signal excited by the electric signal at a target part of the object to be measured, and the laser scanning radar is also used for measuring the distance between the object to be measured and the signal acquisition module;
and the signal processing module is in communication connection with the laser scanning radar, is electrically connected with the signal excitation module and the signal acquisition module, and is used for receiving the magnetoacoustic signals and the distance and processing the magnetoacoustic signals according to the distance so as to obtain magnetoacoustic imaging of the object to be detected.
2. The magnetoacoustic small-animal brain imaging apparatus of claim 1, further comprising a static magnet disposed on the support for generating the magnetic field to excite the target site of the test object with the electrical signal to produce a magnetoacoustic signal.
3. The magnetoacoustic small-animal brain imaging apparatus of claim 1, further comprising a controller and a driving motor, wherein the signal processing module is integrated with the controller, the driving motor is electrically connected to the controller and the signal excitation module, and the controller is configured to control the driving motor to drive the signal excitation module to move to the target site according to the target site.
4. The magnetoacoustic small-animal brain imaging apparatus of claim 3, wherein the controller is further communicatively coupled to the lidar, and the controller is configured to receive a scan result of the lidar and determine the target site based on the scan result.
5. The magnetoacoustic imaging apparatus for a small animal brain according to claim 3, wherein the signal excitation module includes a pin electrode, the driving motor is electrically connected to the pin electrode, and the controller is configured to control the driving motor to drive the pin electrode to move to the target site.
6. The magnetoacoustic small animal brain imaging apparatus of claim 1, wherein the signal acquisition module comprises a detection electrode electrically connected to the signal processing module, the detection electrode configured to detect the electrical signal.
7. The magnetoacoustic small-animal brain imaging apparatus of claim 1, further comprising an anesthetic assembly disposed on the fixation assembly for providing anesthetic to the test subject.
8. The magnetoacoustic small-animal brain imaging apparatus of claim 7, wherein the anesthetic assembly includes an anesthetic storage container and an anesthetic pump, the anesthetic pump is in communication with the anesthetic storage container, and the anesthetic pump is configured to inject an anesthetic at a predetermined time for the analyte.
9. The magnetoacoustic imaging apparatus for a small animal brain according to claim 1, wherein the fixing member includes a fixing table and a plurality of fixing portions, the object to be measured is located on the fixing table, and the plurality of fixing portions are used for fixing different portions of the object to be measured.
10. The small animal brain magnetoacoustic imaging apparatus of claim 1, wherein the signal acquisition module comprises an acoustic probe electrically connected to the signal processing module.
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