CN113711045A - 一种筛选用于治疗或预防polyQ相关的神经退行性疾病的化合物的方法 - Google Patents
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Abstract
本发明涉及一种筛选或鉴定用于治疗或预防polyQ相关的神经退行性疾病的化合物的方法以及由该方法获得的化合物和用途。
Description
PCT国内申请，说明书已公开。
Claims (19)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910180717.1A CN111679082A (zh) | 2019-03-11 | 2019-03-11 | 一种筛选用于治疗或预防polyQ相关的神经退行性疾病的化合物的方法 |
| CN2019101807171 | 2019-03-11 | ||
| CN2019110004158 | 2019-10-21 | ||
| CN201911000415.8A CN112763718A (zh) | 2019-10-21 | 2019-10-21 | 一种筛选用于治疗或预防polyQ相关的神经退行性疾病的化合物的方法 |
| PCT/CN2020/078775 WO2020182143A1 (zh) | 2019-03-11 | 2020-03-11 | 一种筛选用于治疗或预防polyQ相关的神经退行性疾病的化合物的方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113711045A true CN113711045A (zh) | 2021-11-26 |
Family
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| CN202080020716.1A Pending CN113711045A (zh) | 2019-03-11 | 2020-03-11 | 一种筛选用于治疗或预防polyQ相关的神经退行性疾病的化合物的方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20220170930A1 (zh) |
| EP (1) | EP3940384A4 (zh) |
| JP (1) | JP2022525325A (zh) |
| CN (1) | CN113711045A (zh) |
| WO (1) | WO2020182143A1 (zh) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2022140246A1 (en) | 2020-12-21 | 2022-06-30 | Hangzhou Jijing Pharmaceutical Technology Limited | Methods and compounds for targeted autophagy |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004064733A2 (en) * | 2003-01-15 | 2004-08-05 | Board Of Regents, University Of Texas System | The use of c-raf inhibitors for the treatment of neurodegenerative diseases |
| WO2008021210A2 (en) * | 2006-08-11 | 2008-02-21 | Combinatorx, Incorporated | Methods and compositions for the treatment of neurodegenerative disorders |
| WO2010011964A2 (en) * | 2008-07-24 | 2010-01-28 | Siemens Medical Solutions Usa, Inc. | Imaging agents useful for identifying ad pathology |
| WO2014062621A1 (en) * | 2012-10-15 | 2014-04-24 | Stc.Unm | Treatment of autophagy-based disorders and related pharmaceutical compositions, diagnostic and screening assays and kits |
| WO2016114655A1 (en) * | 2015-01-12 | 2016-07-21 | Ry Pharma B.V. | Treating neuromuscular or neurologic disease through reducing gabaergic and/or glycinergic inhibitory neurotransmitter overstimulation |
| US20160296630A1 (en) * | 2012-11-30 | 2016-10-13 | Endocyte, Inc. | Methods for treating cancer using combination therapies |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101224207A (zh) * | 2007-10-12 | 2008-07-23 | 中国科学院上海有机化学研究所 | 具有诱导自吞噬治疗错误折叠蛋白聚集所致疾病的药物及其筛选方法 |
| US20100016221A1 (en) * | 2008-07-17 | 2010-01-21 | Riken | Method of degrading protein by chaperone-mediated autophagy |
| JP6550333B2 (ja) * | 2012-09-27 | 2019-07-24 | ザ ユニヴァーシティ オヴ ブリティッシュ コロンビア | ペプチドに誘導されたタンパク質ノックダウン |
-
2020
- 2020-03-11 WO PCT/CN2020/078775 patent/WO2020182143A1/zh unknown
- 2020-03-11 EP EP20769239.3A patent/EP3940384A4/en active Pending
- 2020-03-11 JP JP2021555238A patent/JP2022525325A/ja active Pending
- 2020-03-11 CN CN202080020716.1A patent/CN113711045A/zh active Pending
- 2020-03-11 US US17/437,968 patent/US20220170930A1/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004064733A2 (en) * | 2003-01-15 | 2004-08-05 | Board Of Regents, University Of Texas System | The use of c-raf inhibitors for the treatment of neurodegenerative diseases |
| WO2008021210A2 (en) * | 2006-08-11 | 2008-02-21 | Combinatorx, Incorporated | Methods and compositions for the treatment of neurodegenerative disorders |
| WO2010011964A2 (en) * | 2008-07-24 | 2010-01-28 | Siemens Medical Solutions Usa, Inc. | Imaging agents useful for identifying ad pathology |
| WO2014062621A1 (en) * | 2012-10-15 | 2014-04-24 | Stc.Unm | Treatment of autophagy-based disorders and related pharmaceutical compositions, diagnostic and screening assays and kits |
| US20160296630A1 (en) * | 2012-11-30 | 2016-10-13 | Endocyte, Inc. | Methods for treating cancer using combination therapies |
| WO2016114655A1 (en) * | 2015-01-12 | 2016-07-21 | Ry Pharma B.V. | Treating neuromuscular or neurologic disease through reducing gabaergic and/or glycinergic inhibitory neurotransmitter overstimulation |
Non-Patent Citations (2)
| Title |
|---|
| NICOLE C MCKNIGHT: "Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC", EMBO J, vol. 31, no. 8, pages 1 - 8 * |
| 宋修云: "10种香豆素衍生物神经保护作用筛选及机制初探", 药学学报, vol. 50, no. 6, pages 699 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2020182143A1 (zh) | 2020-09-17 |
| EP3940384A1 (en) | 2022-01-19 |
| US20220170930A1 (en) | 2022-06-02 |
| JP2022525325A (ja) | 2022-05-12 |
| EP3940384A4 (en) | 2022-12-21 |
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