CN113684407A - Degradable Mg-Zn-Sr-Ag magnesium alloy and preparation method and application thereof - Google Patents

Degradable Mg-Zn-Sr-Ag magnesium alloy and preparation method and application thereof Download PDF

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CN113684407A
CN113684407A CN202111003324.7A CN202111003324A CN113684407A CN 113684407 A CN113684407 A CN 113684407A CN 202111003324 A CN202111003324 A CN 202111003324A CN 113684407 A CN113684407 A CN 113684407A
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magnesium alloy
degradable
alloy
magnesium
metal
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李润霞
高志贤
卞健从
郝建飞
郑黎
于宝义
陈斌
吴惠舒
李文芳
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Dongguan University of Technology
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Dongguan University of Technology
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    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22C—ALLOYS
    • C22C23/00—Alloys based on magnesium
    • C22C23/04—Alloys based on magnesium with zinc or cadmium as the next major constituent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/04—Metals or alloys
    • A61L27/047—Other specific metals or alloys not covered by A61L27/042 - A61L27/045 or A61L27/06
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22C—ALLOYS
    • C22C1/00—Making non-ferrous alloys
    • C22C1/02—Making non-ferrous alloys by melting
    • C22C1/03—Making non-ferrous alloys by melting using master alloys

Abstract

The invention relates to the technical field of biomedical metal implant materials, in particular to a degradable Mg-Zn-Sr-Ag magnesium alloy and a preparation method and application thereof. The degradable Mg-Zn-Sr-Ag magnesium alloy comprises the following elements in percentage by mass: zn3.4-4.3%, Sr0.2-0.5%, Ag0.2-1.0% and the balance Mg; the Mg-Zn-Sr-Ag magnesium alloy can obtain good mechanical property and degradation rate in vivo by regulating and controlling the addition of alloy elements, has high biological safety, good toughness and good corrosion resistance, and can well avoid stress shielding effect and reduce the pain of secondary operation.

Description

Degradable Mg-Zn-Sr-Ag magnesium alloy and preparation method and application thereof
Technical Field
The invention relates to the technical field of biomedical metal implant materials, in particular to a degradable Mg-Zn-Sr-Ag magnesium alloy and a preparation method and application thereof.
Background
At present, the medical metal materials widely applied to clinical use mainly comprise 316 stainless steel, cobalt-chromium alloy, titanium alloy and the like, and the metal materials play an important role in medical clinical application. But their elastic modulus is much different from that of human bone, and stress shielding effect is easily generated. Stainless steel releases toxic metal ions due to corrosion, and phenomena of allergy and poisoning can occur. Although the titanium alloy has good corrosion resistance, the titanium alloy can not be degraded, thereby bringing the pain of secondary operation and improving the cost. The magnesium and the magnesium alloy have high specific strength, high specific rigidity and good biocompatibility, and the density and the elastic modulus of the magnesium alloy are close to those of human bones, so that the stress shielding effect can be well avoided. Magnesium is also a macroelement in human bodies, and cannot generate side effects on human bodies and pain of secondary operations in the natural corrosion and degradation process.
However, how to make magnesium alloy have higher biological safety, good toughness and better corrosion resistance at the same time is still an unsolved problem.
Disclosure of Invention
The invention aims to provide a degradable Mg-Zn-Sr-Ag magnesium alloy and a preparation method and application thereof.
In order to achieve the above object, the present invention provides the following technical solutions:
the invention provides a degradable Mg-Zn-Sr-Ag magnesium alloy, which comprises the following elements in percentage by mass: 3.4-4.3% of Zn, 0.2-0.5% of Sr0.2-1.0% of Ag and the balance of Mg.
Preferably, the degradable Mg-Zn-Sr-Ag magnesium alloy comprises the following components in phase composition: MgZn phase, Mg17Sr2Phase and Mg4An Ag phase.
The invention provides a preparation method of the degradable Mg-Zn-Sr-Ag magnesium alloy, which comprises the following steps:
according to the mass ratio of the degradable Mg-Zn-Sr-Ag magnesium alloy elements, metal magnesium, metal silver, metal zinc and an Mg-Sr intermediate alloy are sequentially smelted and cast to obtain the degradable Mg-Zn-Sr-Ag magnesium alloy.
Preferably, the smelting comprises: melting magnesium metal in an environment with the temperature of 760-800 ℃, then adding silver metal to melt, cooling to 720 ℃, adding an Mg-Sr intermediate alloy, and adding zinc metal to melt after the Mg-Sr intermediate alloy is melted; the smelting is carried out under a protective atmosphere.
Preferably, the Mg-Sr intermediate alloy comprises 20-25% of Sr and the balance of Mg in percentage by mass.
Preferably, the gas providing the protective atmosphere comprises SF6And N2。
Preferably, SF in said protective atmosphere6And N2Is 2: 98.
Preferably, the temperature of the alloy liquid is 700-740 ℃ during the pouring.
Preferably, the preheating temperature of the casting mold for casting is 260-320 ℃.
The invention provides application of the degradable Mg-Zn-Sr-Ag magnesium alloy in the scheme or the degradable Mg-Zn-Sr-Ag magnesium alloy prepared by the preparation method in preparation of biomedical metal materials.
The invention provides a degradable Mg-Zn-Sr-Ag magnesium alloy, which comprises the following elements in percentage by mass: 3.4-4.3% of Zn, 0.2-0.5% of Sr, 0.2-1.0% of Ag and the balance of Mg.
Zn in the degradable Mg-Zn-Sr-Ag magnesium alloy has the solid solution strengthening effect on the magnesium alloy, and meanwhile, the occurrence of non-basal plane slippage of the magnesium alloy at room temperature is effectively promoted, and the plastic processing capacity of the magnesium alloy is improved; the Zn is used as a trace element necessary for a human body, has no cytotoxicity and good biocompatibility, and the content of the Zn is controlled in the range, so that the Mg-Zn-Sr-Ag magnesium alloy is beneficial to having good strength and corrosion resistance. Sr is an important constituent element of human bones, has no cytotoxicity and can promote bone formation, and the content of Sr is controlled in the range, so that the degradable Mg-Zn-Sr-Ag magnesium alloy has high biological safety, good toughness and good corrosion resistance. The Ag has the nonspecific broad-spectrum antibacterial effect, and the magnesium alloy can be ensured to have good mechanical property and corrosion resistance by controlling the content of the Ag within the range.
In conclusion, the degradable Mg-Zn-Sr-Ag magnesium alloy has higher biological safety, good toughness and better corrosion resistance by controlling the types and contents of all elements.
The invention also provides a preparation method of the Mg-Zn-Sr-Ag magnesium alloy in the technical scheme, and the preparation method is simple and easy to operate.
Drawings
FIG. 1 is a microstructure diagram of a Mg-Zn-Sr-Ag-based magnesium alloy produced in example 1;
FIG. 2 is a microstructure diagram of a Mg-Zn-Sr-Ag-based magnesium alloy produced in example 2;
FIG. 3 is a microstructure diagram of a Mg-Zn-Sr-Ag-based magnesium alloy produced in example 3;
FIG. 4 is a microstructure diagram of the Mg-Zn-Sr-Ag based magnesium alloy prepared in comparative example 1;
FIG. 5 is a microstructure diagram of the Mg-Zn-Sr-Ag based magnesium alloy prepared in comparative example 2;
FIG. 6 is a microstructure of the Mg-Zn-Sr-Ag based magnesium alloy prepared in comparative example 3.
Detailed Description
The invention provides an Mg-Zn-Sr-Ag magnesium alloy which comprises the following elements in percentage by mass: 3.4-4.3% of Zn, 0.2-0.5% of Sr, 0.2-1.0% of Ag and the balance of Mg.
The Mg-Zn-Sr-Ag magnesium alloy comprises 3.4-4.3% of Zn by mass, preferably 3.6-4.1% of Zn by mass, and more preferably 4.0% of Zn by mass. In the invention, Zn in the Mg-Zn-Sr-Ag magnesium alloy has the solid solution strengthening effect on the magnesium alloy, and simultaneously, the occurrence of non-basal plane slippage of the magnesium alloy at room temperature is effectively promoted, and the plastic processing capacity of the magnesium alloy is improved; zn is used as a necessary trace element for human bodies, has no cytotoxicity and has good biocompatibility. The invention controls the Zn content in the range, can ensure that the Mg-Zn-Sr-Ag magnesium alloy has better strength and corrosion resistance;
the Mg-Zn-Sr-Ag magnesium alloy comprises 0.2-0.5% of Sr, preferably 0.3-0.5%, and more preferably 0.5% by mass. In the present invention, Sr is an important constituent element of human bone, has no cytotoxicity, and can promote bone formation. When the Sr content is too high, a large amount of second phase is formed in the grain boundary, and the corrosion resistance of the alloy is lowered. The invention controls the Sr content in the range, thereby ensuring that the Mg-Zn-Sr-Ag magnesium alloy has higher biological safety, good toughness and better corrosion resistance.
The Mg-Zn-Sr-Ag magnesium alloy comprises 0.2-1.0% of Ag, preferably 0.2-0.5%, and more preferably 0.5% by mass. In the invention, silver is one of trace elements in human tissues, the trace silver is harmless to human bodies, the Ag element can adsorb bacterial protease, the enzyme with the respiration function can lose the effect, and bacteria can die. The invention can ensure that the Mg-Zn-Sr-Ag magnesium alloy has good mechanical property and corrosion resistance by controlling the Ag content in the range.
The Mg-Zn-Sr-Ag magnesium alloy comprises the balance of Mg.
In terms of phase composition, the degradable Mg-Zn-Sr-Ag magnesium alloy preferably comprises: MgZn phase, Mg17Sr2Phase and Mg4An Ag phase. In the present invention, the MgZn phase is dotted, and the Mg phase is17Sr2The phase is strip-shaped and is uniformly distributed in the matrix, and the Mg4The Ag phase is short and coarse and has the function of refining grains, the MgZn phase and the Mg phase17Sr2Phase and Mg4The Ag phase can improve the strength of the alloy.
In the invention, the average grain size of the degradable Mg-Zn-Sr-Ag magnesium alloy is preferably 80-110 μm.
The invention provides a preparation method of the degradable Mg-Zn-Sr-Ag magnesium alloy, which comprises the following steps:
according to the mass ratio of the degradable Mg-Zn-Sr-Ag magnesium alloy elements, metal magnesium, metal silver, metal zinc and an Mg-Sr intermediate alloy are sequentially smelted and cast to obtain the degradable Mg-Zn-Sr-Ag magnesium alloy.
In the present invention, all the starting materials for the preparation are commercially available products known to those skilled in the art unless otherwise specified.
In the present invention, the metallic magnesium is preferably a magnesium ingot having a purity of 99.94 wt%; the metal silver is preferably silver wire with the purity of 99.99 wt%, and the metal zinc is preferably zinc ingot with the purity of 99.995 wt%; the Mg-Sr intermediate alloy preferably comprises 20-25% of Sr and the balance of Mg in percentage by mass, and the mass percentage of Sr in the Mg-Sr intermediate alloy is more preferably 20%.
In the invention, the amounts of the metal zinc, the metal silver, the Mg-Sr intermediate alloy and the metal magnesium are calculated by referring to the element composition of the Mg-Zn-Sr-Ag magnesium alloy in the technical scheme.
In the present invention, the smelting preferably includes: melting magnesium metal in an environment with the temperature of 760-800 ℃, then adding metal silver until the metal silver is melted, cooling to 720 ℃, adding an Mg-Sr intermediate alloy, and adding metal zinc until the Mg-Sr intermediate alloy is melted. The present invention more preferably melts magnesium metal in an environment of 780 ℃.
In the present invention, the smelting is preferably carried out under a protective atmosphere; the gas providing said protective atmosphere preferably comprises SF6And N2. Invention for said SF6And N2Is prepared byAny particular limitation may be imposed by the use of a compounding ratio known to those skilled in the art. In a specific embodiment of the invention, the SF6And N2Is 2: 98. According to the invention, the protective gas is preferably introduced when the temperature of the furnace rises to 600 ℃.
After the smelting is finished, the obtained alloy liquid is poured. In the invention, the temperature of the alloy liquid is preferably 700-740 ℃, and more preferably 710-720 ℃ when the pouring is carried out; the preheating temperature of a casting mold for casting is preferably 260-320 ℃, and more preferably 280-300 ℃; the casting mould is preferably a ceramic mould; the atmosphere of the casting is preferably SF6And N2The mixed atmosphere of (3); the invention is suitable for the SF in the mixed atmosphere6And N2The compounding ratio of (A) is not particularly limited, and those known to those skilled in the art may be used. In a specific embodiment of the invention, the mixed atmosphere is SF6And N2Is 2: 98.
In the present invention, the purpose of preheating the casting mold is to avoid the problems of composition segregation and non-uniform structure caused by rapid solidification of the alloy liquid.
The invention also provides the application of the Mg-Zn-Sr-Ag magnesium alloy in the technical scheme or the Mg-Zn-Sr-Ag magnesium alloy prepared by the preparation method in the technical scheme in preparation of biomedical metal materials. The method of the present invention is not particularly limited, and the method may be performed by a method known to those skilled in the art.
The following will explain the degradable Mg-Zn-Sr-Ag magnesium alloy and the preparation method and application thereof in detail with reference to the examples, but they should not be construed as limiting the scope of the invention.
Example 1
The degradable Mg-Zn-Sr-Ag magnesium alloy comprises the following components: 3.97% of Zn, 0.43% of Sr, 0.2% of Ag and the balance of Mg;
the adopted raw materials are as follows: a magnesium ingot with the purity of 99.94 wt%, a zinc ingot with the purity of 99.995 wt%, a silver wire with the purity of 99.99 wt% and an Mg-Sr intermediate alloy containing 20 mass percent of Sr;
the preparation process comprises the following steps: 926.16g of magnesium ingot is added into a resistance furnace, the temperature is set to 780 ℃, SF with the volume ratio of 2:98 is introduced when the temperature of the furnace is raised to 600 DEG C6And N2After the magnesium ingot is melted, 2.04g of silver wire is added, the mixture is stirred for 2min, after the temperature is reduced to 720 ℃, 20.4g of Mg-Sr intermediate alloy is added for melting, the mixture is stirred for 4min, 40.8g of zinc ingot is added, the mixture is stirred for 5min after being melted, the mixture is kept stand for 30min, and finally the mixture is poured into a ceramic mold at the temperature of 720 ℃.
FIG. 1 is a microstructure of an Mg-Zn-Sr-Ag magnesium alloy according to example 1, in which the average grain size of the Mg-Zn-Sr-Ag magnesium alloy is 102.63 μm, as can be seen from FIG. 1;
according to the requirements of GB/T228.1-2010, the Mg-Zn-Sr-Ag magnesium alloy in the example 1 is tested for yield strength, tensile strength and elongation; the results show that: the magnesium alloy of example 1 has yield strength and tensile strength of 97MPa and 173MPa, respectively, and elongation of 11.58%;
the corrosion rate was 0.7058 mm/year for 8 days in Hank's simulated body fluid as required by ASTM G31-72.
Example 2
The degradable Mg-Zn-Sr-Ag magnesium alloy comprises the following components: 3.97% of Zn, 0.43% of Sr, 0.5% of Ag and the balance of Mg;
the adopted raw materials are as follows: a magnesium ingot with the purity of 99.94 wt%, a zinc ingot with the purity of 99.995 wt%, a silver wire with the purity of 99.99 wt% and an Mg-Sr intermediate alloy containing 20 mass percent of Sr;
the preparation process comprises the following steps: 923.1g of magnesium ingot is added into a resistance furnace, the temperature is set to 780 ℃, SF with the volume ratio of 2:98 is introduced when the temperature of the furnace is raised to 600 DEG C6And N2After the magnesium ingot is melted, 5.1g of silver wire is added, the mixture is stirred for 2min, 25.5g of Mg-Sr intermediate alloy is added for melting, the mixture is stirred for 4min, the temperature is reduced to 720 ℃, 40.8g of zinc ingot is added, the mixture is stirred for 5min after melting, the mixture is kept stand for 30min, and finally the mixture is poured into a ceramic mold at the temperature of 720 ℃.
FIG. 2 is a microstructure of the Mg-Zn-Sr-Ag magnesium alloy of example 2, and it is understood from FIG. 2 that the Mg-Zn-Sr-Ag magnesium alloy has an average crystal grain size of 83.28. mu.m;
according to the requirements of GB/T228.1-2010, the Mg-Zn-Sr-Ag magnesium alloy in the example 2 is tested for yield strength, tensile strength and elongation; the results show that: the yield strength and the tensile strength of the magnesium alloy in the embodiment 2 are 102MPa and 182MPa respectively, and the elongation is 12.20 percent;
the corrosion rate was 0.5431 mm/year for 8 days as tested in Hank's simulated body fluid according to ASTM G31-72.
Example 3
The degradable Mg-Zn-Sr-Ag magnesium alloy comprises the following components: 3.97% of Zn, 0.43% of Sr, 1.0% of Ag and the balance of Mg;
the adopted raw materials are as follows: a magnesium ingot with the purity of 99.94 wt%, a zinc ingot with the purity of 99.995 wt%, a silver wire with the purity of 99.99 wt% and an Mg-Sr intermediate alloy containing 20 mass percent of Sr;
the preparation process comprises the following steps: 918g of magnesium ingot is added into a resistance furnace, the temperature is set to be 780 ℃, SF with the volume ratio of 2:98 is introduced when the temperature of the furnace is increased to 600 DEG C6And N2After the magnesium ingot is melted, 10.2g of silver wire is added, the mixture is stirred for 2min, 25.5g of Mg-Sr intermediate alloy is added for melting, the mixture is stirred for 4min, the temperature is reduced to 720 ℃, 40.8g of zinc ingot is added, the mixture is stirred for 5min after melting, the mixture is kept stand for 30min, and finally the mixture is poured into a ceramic mold at the temperature of 720 ℃.
FIG. 3 is a microstructure of an Mg-Zn-Sr-Ag magnesium alloy according to example 3, in which the average grain size of the Mg-Zn-Sr-Ag magnesium alloy is 102.63 μm, as is clear from FIG. 3;
according to the requirements of GB/T228.1-2010, the Mg-Zn-Sr-Ag magnesium alloy in the example 3 is tested for yield strength, tensile strength and elongation; the results show that: the yield strength and the tensile strength of the magnesium alloy in the embodiment 3 are 85MPa and 175MPa respectively, and the elongation is 11.65%;
the corrosion rate was 0.7287 mm/year for 8 days in Hank's simulated body fluid as required by ASTM G31-72.
Comparative example 1
Preparation of silver-free Mg-Zn-Sr magnesium alloy
Composition of the magnesium alloy: 3.98 percent of Zn, 0.49 percent of Sr and the balance of Mg;
the adopted raw materials are as follows: a magnesium ingot with the purity of 99.94 wt%, a zinc ingot with the purity of 99.995 wt% and an Mg-Sr intermediate alloy containing 20 mass percent of Sr;
the preparation process comprises the following steps: 928.2g of magnesium ingot is added into a resistance furnace, the temperature is set to 780 ℃, SF with the volume ratio of 2:98 is introduced when the temperature of the furnace is raised to 600 DEG C6And N2After the magnesium ingot is melted, cooling to 720 ℃, adding 25.5g of Mg-Sr intermediate alloy for melting, stirring for 4min, adding 40.8g of zinc ingot, stirring for 5min after melting, standing for 30min, and finally pouring into a ceramic mold at the temperature of 720 ℃.
FIG. 4 is a microstructure of the Mg-Zn-Sr-Ag based magnesium alloy according to comparative example 1, and it is understood from FIG. 4 that the average crystal grain size of the magnesium alloy according to comparative example 1 is 102.63 μm;
according to the GB/T228.1-2010 requirement, the magnesium alloy of comparative example 1 is tested for yield strength, tensile strength and elongation; the results show that: comparative example 1 the magnesium alloy had yield strength and tensile strength of 82MPa and 161MPa, respectively, and elongation of 10.30%;
the corrosion rate was 0.7631 mm/year for 8 days in Hank's simulated body fluid as required by ASTM G31-72.
Comparative example 2
Preparing Mg-Zn-Sr-Ag magnesium alloy with excessive silver content
The degradable medical alloy comprises the following components: 3.98% of Zn, 0.49% of Sr, 2.0% of Ag and the balance of Mg;
the adopted raw materials are as follows: a magnesium ingot with the purity of 99.94 wt%, a zinc ingot with the purity of 99.995 wt%, a silver wire with the purity of 99.99 wt% and an Mg-Sr intermediate alloy containing 20 mass percent of Sr;
the preparation process comprises the following steps: 907.8g of magnesium ingot is added into a resistance furnace, the temperature is set to 780 ℃, SF with the volume ratio of 2:98 is introduced when the temperature of the furnace is raised to 600 DEG C6And N2After the magnesium ingot is melted, 20.4g of silver wire is added, the mixture is stirred for 2min, 25.5g of Mg-Sr intermediate alloy is added for melting, the mixture is stirred for 4min, the temperature is reduced to 720 ℃, 40.8g of zinc ingot is added, the mixture is stirred for 5min after melting, the mixture is kept stand for 30min, and finally the mixture is poured into a ceramic mold at the temperature of 720 ℃.
FIG. 5 is a microstructure of the Mg-Zn-Sr-Ag magnesium alloy according to comparative example 2, and it is understood from FIG. 5 that the Mg-Zn-Sr-Ag magnesium alloy has an average crystal grain size of 110.43 μm;
according to the GB/T228.1-2010 requirement, the Mg-Zn-Sr-Ag series magnesium alloy of the comparative example 2 is tested for yield strength, tensile strength and elongation; the results show that: comparative example 2 the magnesium alloy had yield strength and tensile strength of 81MPa and 142MPa, respectively, and elongation of 6.67%;
the corrosion rate was 0.9773 mm/year for 8 days in Hank's simulated body fluid as required by ASTM G31-72.
Comparative example 3
Preparing Mg-Zn-Sr-Ag magnesium alloy with excessive strontium content
The degradable medical alloy comprises the following components: 3.98% of Zn, 1.0% of Sr, 0.5% of Ag and the balance of Mg;
the adopted raw materials are as follows: a magnesium ingot with the purity of 99.94 wt%, a zinc ingot with the purity of 99.995 wt%, a silver wire with the purity of 99.99 wt% and an Mg-Sr intermediate alloy containing 20 mass percent of Sr;
the preparation process comprises the following steps: 948.6g of magnesium ingot is added into a resistance furnace, the temperature is set to 780 ℃, SF with the volume ratio of 2:98 is introduced when the temperature of the furnace is raised to 600 DEG C6And N2After the magnesium ingot is melted, 5.1g of silver wire is added, the mixture is stirred for 2min, 25.5g of Mg-Sr intermediate alloy is added for melting, the mixture is stirred for 4min, the temperature is reduced to 720 ℃, 40.8g of zinc ingot is added, the mixture is stirred for 5min after melting, the mixture is kept stand for 30min, and finally the mixture is poured into a ceramic mold at the temperature of 720 ℃.
FIG. 6 is a microstructure of the Mg-Zn-Sr-Ag magnesium alloy according to comparative example 3, and it is understood from FIG. 6 that the Mg-Zn-Sr-Ag magnesium alloy has an average crystal grain size of 121.17 μm;
according to the GB/T228.1-2010 requirement, the Mg-Zn-Sr-Ag series magnesium alloy in the comparative example 3 is tested for yield strength, tensile strength and elongation; the results show that: comparative example 3 the yield strength and tensile strength of the magnesium alloy were 72MPa and 128MPa, respectively, and the elongation was 5.89%;
the corrosion rate was 1.2014 mm/year for 8 days in Hank's simulated body fluid as required by ASTM G31-72.
As can be seen from the above examples and comparative examples, the magnesium alloy obtained by controlling the elemental composition and content of the magnesium alloy in the invention has high biological safety, good toughness and good degradation controllability.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.

Claims (10)

1. The degradable Mg-Zn-Sr-Ag magnesium alloy is characterized by comprising the following elements in percentage by mass: 3.4-4.3% of Zn, 0.2-0.5% of Sr, 0.2-1.0% of Ag and the balance of Mg.
2. The degradable Mg-Zn-Sr-Ag based magnesium alloy according to claim 1, wherein the degradable Mg-Zn-Sr-Ag based magnesium alloy comprises, in phase composition: MgZn phase, Mg17Sr2Phase and Mg4An Ag phase.
3. The method for producing a degradable Mg-Zn-Sr-Ag magnesium alloy according to claim 1 or 2, comprising the steps of:
according to the mass ratio of the degradable Mg-Zn-Sr-Ag magnesium alloy elements, metal magnesium, metal silver, metal zinc and an Mg-Sr intermediate alloy are sequentially smelted and cast to obtain the degradable Mg-Zn-Sr-Ag magnesium alloy.
4. The method of manufacturing of claim 3, wherein the smelting comprises: melting magnesium metal in an environment with the temperature of 760-800 ℃, then adding silver metal to melt, cooling to 720 ℃, adding an Mg-Sr intermediate alloy, and adding zinc metal to melt after the Mg-Sr intermediate alloy is melted; the smelting is carried out under a protective atmosphere.
5. The production method according to claim 3 or 4, wherein the Mg-Sr master alloy comprises 20-25% of Sr and the balance of Mg, in terms of mass percentage.
6. The method of claim 4, wherein the gas providing the protective atmosphere comprises SF6And N2。
7. Preparation method according to claim 6, characterized in that said protective atmosphere is SF6And N2Is 2: 98.
8. The method according to claim 3, wherein the casting is performed at a temperature of 700 to 740 ℃.
9. The preparation method according to claim 3 or 8, wherein the preheating temperature of a casting mold for casting is 260-320 ℃.
10. The degradable Mg-Zn-Sr-Ag magnesium alloy according to claim 1 or 2 or the degradable Mg-Zn-Sr-Ag magnesium alloy prepared by the preparation method according to any one of claims 3 to 9, and the application thereof in preparing biomedical metal materials.
CN202111003324.7A 2021-08-30 2021-08-30 Degradable Mg-Zn-Sr-Ag magnesium alloy and preparation method and application thereof Pending CN113684407A (en)

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US20140248288A1 (en) * 2011-10-06 2014-09-04 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Biodegradable metal alloys
CN104630587A (en) * 2015-02-28 2015-05-20 天津理工大学 Degradable magnesium alloy plate and bar for fracture internal fixation and preparation methods thereof
CN110373587A (en) * 2019-07-23 2019-10-25 广东省医疗器械研究所 A kind of self-bone grafting antibacterial magnesium alloy and the preparation method and application thereof
CN113106312A (en) * 2021-04-12 2021-07-13 东莞理工学院 Degradable medical alloy and preparation method and application thereof

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005240129A (en) * 2004-02-27 2005-09-08 Mitsubishi Alum Co Ltd Heat resistant magnesium alloy casting
US20140248288A1 (en) * 2011-10-06 2014-09-04 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Biodegradable metal alloys
CN103184379A (en) * 2013-03-29 2013-07-03 江苏康欣医疗设备有限公司 Biodegradable Mg-Gd-Zn-Ag-Zr series magnesium alloy and preparation method thereof
CN104630587A (en) * 2015-02-28 2015-05-20 天津理工大学 Degradable magnesium alloy plate and bar for fracture internal fixation and preparation methods thereof
CN110373587A (en) * 2019-07-23 2019-10-25 广东省医疗器械研究所 A kind of self-bone grafting antibacterial magnesium alloy and the preparation method and application thereof
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