CN113684132A - High-flux drawer type isolation incubator system - Google Patents
High-flux drawer type isolation incubator system Download PDFInfo
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- CN113684132A CN113684132A CN202110993199.2A CN202110993199A CN113684132A CN 113684132 A CN113684132 A CN 113684132A CN 202110993199 A CN202110993199 A CN 202110993199A CN 113684132 A CN113684132 A CN 113684132A
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- 238000002955 isolation Methods 0.000 title claims abstract description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 27
- 238000012544 monitoring process Methods 0.000 claims abstract description 11
- 238000007789 sealing Methods 0.000 claims description 5
- 230000004907 flux Effects 0.000 claims description 3
- 210000003437 trachea Anatomy 0.000 claims 1
- 238000009429 electrical wiring Methods 0.000 abstract description 7
- 238000012423 maintenance Methods 0.000 abstract description 4
- 229940079593 drug Drugs 0.000 abstract description 3
- 239000003814 drug Substances 0.000 abstract description 3
- 230000000712 assembly Effects 0.000 description 11
- 238000000429 assembly Methods 0.000 description 11
- 238000013461 design Methods 0.000 description 11
- 238000012546 transfer Methods 0.000 description 8
- 238000010586 diagram Methods 0.000 description 4
- 238000011534 incubation Methods 0.000 description 4
- 238000004113 cell culture Methods 0.000 description 3
- 238000012258 culturing Methods 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 206010063385 Intellectualisation Diseases 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229960000074 biopharmaceutical Drugs 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
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- 230000001105 regulatory effect Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
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- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/42—Integrated assemblies, e.g. cassettes or cartridges
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- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/08—Flask, bottle or test tube
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- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/06—Nozzles; Sprayers; Spargers; Diffusers
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- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
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- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
- C12M41/34—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of gas
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- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/48—Automatic or computerized control
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Abstract
The invention relates to the technical field of biological medicines, in particular to a high-flux drawer type isolation incubator system which comprises a bottom bin frame assembly, a middle frame assembly, a culture unit control assembly and a culture unit monitoring assembly, wherein the culture unit assembly is an independent culture unit and comprises a culture unit slide rail assembly, a culture unit electrical wiring assembly, a culture unit water and gas supply assembly, a culture unit water and gas switching port, a culture unit emergency door, a culture unit locking support, a culture unit sliding table driving assembly, a culture unit electrical switching port, a culture unit cabin assembly, a culture unit air duct assembly and a culture bottle, the middle frame assembly is arranged on the end face of the bottom bin frame assembly, and a plurality of culture unit mounting rails are uniformly arranged in the middle frame assembly and correspond to the culture unit assembly Easy maintainability and easy replaceability reduce customer's use and maintenance cost.
Description
Technical Field
The invention relates to the technical field of biological medicines, in particular to a high-flux drawer type isolation incubator system.
Background
Biopharmaceuticals are in a fast-growing phase and are increasingly important for use in cell culture expansion systems. Customers want to accommodate as many flasks as possible in a limited space, and for this reason, array requirements are placed on the culture units in the apparatus; meanwhile, due to the individuation of biological medicines, the influence between different samples must be minimized in the culture process, so that the isolation requirement is provided for the culture unit in the equipment, and in addition, the culture unit is required to be low in design cost, strong in reliability, easy to maintain and easy to replace, and the use and maintenance cost of customers is reduced.
Disclosure of Invention
The invention aims to provide a high-flux drawer type isolated incubator system to solve the problems in the background art.
In order to achieve the purpose, the invention provides the following technical scheme:
a high-flux drawer type isolation incubator system comprises a bottom bin frame assembly, a middle frame assembly, a culture unit control assembly and a culture unit monitoring assembly, wherein the culture unit assembly is an independent culture unit and comprises a culture unit slide rail assembly, a culture unit electrical wiring assembly, a culture unit water and gas supply assembly, a culture unit water and gas transfer port, a culture unit emergency door, a culture unit locking support, a culture unit sliding table driving assembly, a culture unit electrical transfer port, a culture unit cabin assembly, a culture unit air duct assembly and a culture bottle, the middle frame assembly is arranged on the end face of the bottom bin frame assembly, a plurality of culture unit mounting rails are uniformly arranged in the middle frame assembly and correspond to the culture unit assembly, the culture unit assembly is mounted on the culture unit mounting rails, the culture unit control assembly and the culture unit monitoring assembly are correspondingly arranged on the bottom bin frame assembly respectively.
In a preferred embodiment of the present invention, the culture unit assembly is an independent culture unit, and the bottom compartment frame assembly, the middle frame assembly and the culture unit assembly are auxiliary systems.
As a preferable mode of the present invention, the cultivation unit assemblies are connected to the cultivation unit mounting rail in a sliding manner by the cultivation unit slide rail assembly, and form a drawer type structure, and the cultivation unit assemblies are arranged in multiple groups and are arranged independently from each other.
As a preferable scheme of the invention, the culture unit assembly is provided with a culture unit slide rail assembly, the left side surface of the culture unit slide rail assembly is provided with a culture unit electrical wiring assembly, the right side surface of the culture unit slide rail assembly is provided with a culture unit water and gas supply assembly, the right front side of the culture unit slide rail assembly is provided with a culture unit water and gas transfer port, the front side of the culture unit slide rail assembly is provided with a culture unit emergency door, the front side of the culture unit slide rail assembly is provided with a culture unit locking bracket which is arranged on a vehicle up and down, the left rear side of the culture unit slide rail assembly is provided with a culture unit sliding table driving assembly, the left front side of the culture unit slide rail assembly is provided with a culture unit electrical transfer port, the end part of the culture unit slide rail assembly is provided with a culture unit cabin assembly, and the end part of the culture unit cabin assembly is provided with a culture unit air duct assembly, the inside of cultivateing unit sliding rail set spare is provided with the blake bottle, cultivate unit sliding rail set spare, go up and be provided with the sealed door of cultivation unit with the blake bottle correspondence.
As a preferable scheme of the invention, the bottom bin frame assembly is internally provided with air and water pipes in one-to-one correspondence with the culture unit assemblies respectively, and the air and water pipes comprise air pipes and water pipes.
In a preferred embodiment of the present invention, cables are provided on the right side surface of the middle frame assembly in one-to-one correspondence to the cultivation unit assemblies, and the cultivation unit assemblies are connected to a higher-level device through a pipeline.
Compared with the prior art, the invention has the beneficial effects that:
1. in the invention, the mass production is realized through the array design, the culture flux of single equipment is greatly improved, the equipment manufacturing cost is reduced, and the equipment purchasing cost is indirectly reduced.
2. According to the invention, through the design of the isolated culture units, the possibility of mutual influence among different samples is obstructed, the complexity of the integrated design of the equipment system is reduced, and all the culture units can be quickly accessed into the upper-level equipment system through the concentrated adapter ports.
3. According to the invention, the drawer type design is adopted, so that the convenience of assembly, maintenance and replacement of the culture unit is greatly improved, and the requirements of real quick assembly, quick disassembly and quick replacement are met.
4. According to the invention, through a high-degree modular design, the culture unit can be conveniently disassembled and cleaned, the volume of the culture unit is reduced as much as possible, and the use efficiency of a single device is indirectly improved.
5. According to the invention, through the modular design, the rapid array deployment of the culture units can be realized, and the working content of equipment flux upgrading is greatly simplified.
6. According to the invention, through a linkage design, the functions of automatically opening the door when the culture bottle slides out and automatically closing the door for sealing when the culture bottle is recovered are realized, the use of electrical functional elements is reduced, and the equipment cost is reduced.
7. According to the invention, the automation and the intellectualization of the culture process of all culture units and the automatic acquisition, analysis and processing of all data are realized through the linkage design intellectualized design.
Drawings
FIG. 1 is a schematic diagram of a front view of the system of the present invention;
FIG. 2 is a schematic diagram of the right side view of FIG. 1 according to the present invention;
FIG. 3 is a schematic view of the axial structure of the independent culture unit of the present invention;
FIG. 4 is a schematic view of the partially open axial configuration of FIG. 3 in accordance with the present invention;
FIG. 5 is a schematic diagram of the basic structure of the system of the present invention;
FIG. 6 is a schematic diagram of the system workflow structure of the present invention.
In the figure: 1. a bottom bin frame assembly; 2. a middle frame assembly; 3. a culture unit assembly; 4. a culture unit control assembly; 5. a culture unit monitoring assembly; 6. a culture unit mounting rail; 7. a gas-water pipe; 8. a cable; 301. a culturing unit slide rail assembly; 302. an incubation unit electrical wiring assembly; 303. the culture unit supplies water and gas to the assembly; 304. a water-gas transfer port of the culture unit; 305. a culturing unit emergency door; 306. a culture unit locking bracket; 307. a culture unit slide table drive assembly; 308. an electrical transfer port of the culture unit; 309. a culture unit capsule body assembly; 310. a culture unit air duct assembly; 311. a culture bottle; 312. the culture unit is sealed with a door.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, rather than all embodiments, and all other embodiments obtained by a person of ordinary skill in the art without any creative work based on the embodiments of the present invention belong to the protection scope of the present invention.
While several embodiments of the present invention will be described more fully hereinafter with reference to the accompanying drawings, in order to facilitate an understanding of the invention, the invention may be embodied in many different forms and should not be construed as limited to the embodiments set forth herein, but rather should be construed to provide a more complete disclosure of the invention.
It will be understood that when an element is referred to as being "secured to" another element, it can be directly on the other element or intervening elements may also be present, that when an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present, and that the terms "vertical", "horizontal", "left", "right" and the like are used herein for descriptive purposes only.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs, and the terms used herein in the specification of the present invention are for the purpose of describing particular embodiments only and are not intended to limit the present invention, and the term "and/or" as used herein includes any and all combinations of one or more of the associated listed items.
Referring to fig. 1-5, the present invention provides a technical solution:
a high-flux drawer type isolation incubator system comprises a bottom bin frame assembly 1, a middle frame assembly 2, a culture unit assembly 3, a culture unit control assembly 4 and a culture unit monitoring assembly 5, wherein the culture unit assembly 3 is an independent culture unit and comprises a culture unit slide rail assembly 301, a culture unit electrical wiring assembly 302, a culture unit water and gas supply assembly 303, a culture unit water and gas switching port 304, a culture unit emergency door 305, a culture unit locking support 306, a culture unit sliding table driving assembly 307, a culture unit electrical switching port 308, a culture unit cabin assembly 309, a culture unit air channel assembly 310 and a culture bottle 311, the middle frame assembly 2 is arranged on the end face of the bottom bin frame assembly 1, a plurality of culture unit mounting rails 7 are uniformly arranged in the middle frame assembly 2 and correspond to the culture unit assembly 3, the culture unit assembly 3 is mounted on the culture unit mounting rails 7, the culture unit control assembly 4 and the culture unit monitoring assembly 5 are respectively and correspondingly arranged on the bottom bin frame assembly 1.
In a further preferred embodiment of the present invention, the culture unit assembly 3 is an independent culture unit, and the bottom chamber frame assembly 1, the middle frame assembly 2, and the culture unit assembly 3 are auxiliary systems.
As a further preferable scheme of the invention, the culture unit assemblies 3 are connected with the culture unit mounting rails 7 in a sliding way through the culture unit slide rail assemblies 301 and form a drawer type structure, and the culture unit assemblies 3 are arranged in multiple groups and are mutually independent.
As a further preferable scheme of the present invention, the cultivation unit assembly 3 is provided with a cultivation unit slide rail assembly 301, the left side surface of the cultivation unit slide rail assembly 301 is provided with a cultivation unit electrical wiring assembly 302, the right side surface of the cultivation unit slide rail assembly 301 is provided with a cultivation unit water and gas supply assembly 303, the right front side of the cultivation unit slide rail assembly 301 is provided with a cultivation unit water and gas transfer port 304, the front side of the cultivation unit slide rail assembly 301 is provided with a cultivation unit emergency door 305, the front side of the cultivation unit slide rail assembly 301 is provided with a cultivation unit locking bracket 306 up and down, the left rear side of the cultivation unit slide rail assembly 301 is provided with a cultivation unit sliding table driving assembly 307, the left front side of the cultivation unit slide rail assembly 301 is provided with a cultivation unit electrical transfer port 308, the end of the cultivation unit slide rail assembly 301 is provided with a cultivation unit cabin assembly 309, the end of the cultivation unit cabin assembly 309 is provided with a cultivation unit air duct assembly 310, the culture unit slide rail assembly 301 is internally provided with a culture bottle 311, and a culture unit sealing door 312 is arranged on the culture unit slide rail assembly 301 and corresponds to the culture bottle 311.
As a further preferable scheme of the present invention, the air-water pipes 8 are arranged inside the bottom bin frame assembly 1 and respectively corresponding to the culture unit assemblies 3 one by one, and the air-water pipes 8 comprise air pipes and water pipes.
As a further preferable aspect of the present invention, cables 9 are provided on the right side surface of the middle frame assembly 2 in one-to-one correspondence with the cultivation unit assemblies 3, and the cultivation unit assemblies 3 are connected to a higher-level device through pipes. The specific implementation case is as follows:
as shown in FIGS. 5 and 6, the incubator system achieves the goal of high throughput, isolated culture by sequentially installing a specific number of culture units within a fixed system frame.
The independent culture unit is a complete culture system and can provide all functions required by cell culture, including culture gas access, culture moisture supply, culture temperature control, automatic culture bottle sliding-in and sliding-out mechanism, culture environment sealing, culture gas concentration monitoring and the like. All water, gas and electricity can be connected with the upper-level system by combining and switching to a specific and extremely small number of switching ports. Meanwhile, through checking the structural design of the cabin body and converting the locking mode, each independent culture unit is provided with an independent mounting rail, so that the independent culture units can be quickly assembled and disassembled. In addition, an emergency door for processing emergency situations is arranged on the culture unit, so that culture bottles in a faulty culture unit can be quickly transferred when a single culture unit is out of line and has a fault.
The frame of this cultivation system provides and mates the interface with the installation of last one-level system, provides the access interface of all independent cultivation units simultaneously, because the array of independent cultivation unit arranges, and water route, circuit, the gas circuit in the system frame all can realize the arrangement of array, greatly improves the convenience of the assembly of complete machine equipment, maintenance. Meanwhile, a laminar flow system is added outside the system frame, so that the air among the culture boxes is always in a flowing state, and clean air is continuously provided for each culture unit.
1) The bottom bin frame assembly 1 provides the main mounting base function of the system, and meanwhile, the internal culture unit control assembly 4 and the culture unit monitoring assembly 5 are arranged;
2) the middle frame component 2 provides a mounting base function of the independent culture unit and simultaneously provides a mounting interface with a previous-level system;
3) the culture unit component 3 realizes the complete and independent cell culture function;
4) the culture unit control component 4 controls the environmental humidity, the environmental temperature and the gas solubility in the independent culture unit;
5) and the culture unit monitoring assembly 5 monitors the environment humidity, the environment temperature and the gas solubility in the independent culture unit.
The culture unit assembly 3 is composed of the following components, and is shown in fig. 3 in an isometric view.
1) The culture unit bin body assembly 309 provides the function of an assembly base for all parts of the independent culture unit;
2) the culture unit slide rail assembly 301 provides the function of automatically sliding in and out the culture bottle;
3) the culture unit sliding table driving assembly 307 provides power for sliding the sliding rail in and out;
4) the culture unit air channel assembly 310 is internally provided with a circulating fan, and has the functions of uniformly mixing air in the independent culture unit and uniformly regulating humidity;
5) culture unit water and air supply assembly 303-providing clean air, CO2 and water source for the culture unit;
6) incubation unit electrical wiring assembly 302 — integrates all of the wiring harnesses of an individual incubation unit and provides a quick-connect interface with the intermediate frame of the incubation bay.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (6)
1. The utility model provides a high flux drawer type isolation incubator system, includes end storehouse frame subassembly (1), middle frame subassembly (2), cultivates unit subassembly (3), cultivates unit control assembly (4) and cultivates unit monitoring components (5), its characterized in that: the culture unit component (3) is an independent culture unit and comprises a culture unit slide rail component (301), a culture unit electric wiring component (302), a culture unit water supply and air supply component (303), a culture unit water-air switching port (304), a culture unit emergency door (305), a culture unit locking support (306), a culture unit sliding table driving component (307), a culture unit electric switching port (308), a culture unit cabin component (309), a culture unit air duct component (310), a culture bottle (311) and a culture unit sealing door (312), wherein a middle frame component (2) is arranged on the end face of the bottom cabin frame component (1), a plurality of culture unit mounting rails (7) are uniformly arranged inside the middle frame component (2) and correspond to the culture unit component (3), and the culture unit component (3) is arranged on the culture unit mounting rails (7), the culture unit control assembly (4) and the culture unit monitoring assembly (5) are respectively and correspondingly arranged on the bottom bin frame assembly (1).
2. The high throughput drawer-type isolation incubator system of claim 1, wherein: the culture unit assembly (3) is an independent culture unit, and the bottom bin frame assembly (1), the middle frame assembly (2) and the culture unit assembly (3) are auxiliary systems.
3. The high throughput drawer-type isolation incubator system of claim 2, wherein: the culture unit assembly (3) is connected with the culture unit mounting rail (7) in a sliding mode through the culture unit sliding rail assembly (301) and forms a drawer type structure, and the culture unit assembly (3) is provided with multiple groups and is arranged independently.
4. The high throughput drawer-type isolation incubator system of claim 3, wherein: cultivate unit slide rail set spare (3) and be provided with and cultivate unit slide rail set spare (301), the left surface of cultivateing unit slide rail set spare (301) is provided with cultivates unit electric wiring subassembly (302), the right flank of cultivateing unit slide rail set spare (301) is provided with cultivates unit water supply air feed subassembly (303), the right front side of cultivateing unit slide rail set spare (301) is provided with cultivates unit aqueous vapor switching mouth (304), the front side of cultivateing unit slide rail set spare (301) is provided with cultivates unit emergency door (305), it cultivates unit locking support (306) to be provided with the car from top to bottom to cultivate the front side of unit slide rail set spare (301), the left rear side of cultivateing unit slide rail set spare (301) is provided with cultivates unit slip table drive assembly (307), the left front side of cultivateing unit slide rail set spare (301) is provided with cultivates unit electric switching mouth (308), the tip of cultivateing unit slide rail set spare (301) is provided with cultivates unit cabin body subassembly (309), the tip of cultivateing unit cabin body subassembly (309) is provided with cultivates unit wind channel subassembly (310), the inside of cultivateing unit slide rail set spare (301) is provided with blake bottle (311), cultivate on the unit slide rail set spare (301) and correspond with blake bottle (311) and be provided with cultivation unit sealing door (312).
5. The high throughput drawer-type isolation incubator system of claim 4, wherein: the inside of end storehouse frame subassembly (1) and respectively with cultivate unit component (3) one-to-one and be provided with gas-water pipe (8), gas-water pipe (8) include trachea and water pipe.
6. The high throughput drawer-type isolation incubator system of claim 5, wherein: the right side face of the middle frame component (2) is provided with cables (9) in one-to-one correspondence with the culture unit components (3), and the culture unit components (3) are connected to superior equipment through pipelines.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202110993199.2A CN113684132A (en) | 2021-08-26 | 2021-08-26 | High-flux drawer type isolation incubator system |
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| CN202110993199.2A CN113684132A (en) | 2021-08-26 | 2021-08-26 | High-flux drawer type isolation incubator system |
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