CN113683618B - Flumazenil Production System - Google Patents
Flumazenil Production System Download PDFInfo
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- CN113683618B CN113683618B CN202110981006.1A CN202110981006A CN113683618B CN 113683618 B CN113683618 B CN 113683618B CN 202110981006 A CN202110981006 A CN 202110981006A CN 113683618 B CN113683618 B CN 113683618B
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B13/00—Accessories or details of general applicability for machines or apparatus for cleaning
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B3/00—Cleaning by methods involving the use or presence of liquid or steam
- B08B3/02—Cleaning by the force of jets or sprays
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B3/00—Cleaning by methods involving the use or presence of liquid or steam
- B08B3/04—Cleaning involving contact with liquid
- B08B3/08—Cleaning involving contact with liquid the liquid having chemical or dissolving effect
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B11/00—Machines or apparatus for drying solid materials or objects with movement which is non-progressive
- F26B11/12—Machines or apparatus for drying solid materials or objects with movement which is non-progressive in stationary drums or other mainly-closed receptacles with moving stirring devices
- F26B11/14—Machines or apparatus for drying solid materials or objects with movement which is non-progressive in stationary drums or other mainly-closed receptacles with moving stirring devices the stirring device moving in a horizontal or slightly-inclined plane
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B21/00—Arrangements for supplying or controlling air or other gases for drying solid materials or objects
- F26B21/001—Air generating units, e.g. movable or independent of drying enclosure
- F26B21/002—Air generating units, e.g. movable or independent of drying enclosure with means for indirect air heating, i.e. using heat exchangers
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B21/00—Arrangements for supplying or controlling air or other gases for drying solid materials or objects
- F26B21/50—Ducting arrangements from the source of air or other gases to the materials or objects being dried
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B25/00—Details of general application not covered by group F26B21/00 or F26B23/00
- F26B25/04—Agitating, stirring, or scraping devices
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B3/00—Drying solid materials or objects by processes involving the application of heat
- F26B3/02—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air
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Abstract
本发明涉及药物生产技术领域，具体地说，涉及一种氟马西尼生产工艺及系统，该系统包括精制罐，精制罐可转动地设于一安装座上；精制罐内设有空腔，空腔内平行设有两块隔板，隔板用于将空腔分隔成储液腔和处理腔，隔板的中部处均设有通孔；处理腔内设有料管，料管端部设有用于与隔板相配合对通孔进行封堵的堵板，堵板上设有漏孔，料管伸出精制罐的端部设有固定环，伸出精制罐的料管上套设有用于推动固定环上移驱动堵板贴合隔板的第一弹簧，处理腔内设有用于对滤渣进行干燥的风干机构。该系统操作方便、节能，提高了生产效率。
The invention relates to the technical field of pharmaceutical production, in particular to a flumazenil production process and system. The system includes a refining tank, which is rotatably arranged on a mounting seat; the refining tank is provided with a cavity, Two partitions are arranged in parallel in the cavity. The partitions are used to separate the cavity into a liquid storage cavity and a processing cavity. The middle of the partitions are provided with through holes; the processing cavity is provided with a material pipe, and the end of the material pipe is provided There is a blocking plate used to block the through hole in cooperation with the partition plate. The blocking plate is provided with leakage holes. The end of the material pipe extending out of the refining tank is provided with a fixing ring, and the material pipe extending out of the refining tank is sleeved with a function An air-drying mechanism for drying the filter residue is arranged in the treatment chamber for pushing the fixing ring upward to drive the blocking plate to fit the first spring. The system is easy to operate, saves energy, and improves production efficiency.
Description
Technical Field
The invention relates to the technical field of medicine production, in particular to a flumazenil production system.
Background
Flumazenil is a benzodiazepine receptor selective antagonist, acts on benzodiazepine receptors in the brain, blocks the receptors without producing benzodiazepine drug effects, and is clinically used for terminating general anesthesia induced and maintained by benzodiazepine drugs and for emergency treatment of drug intoxication.
Flumazenil is an important medicine in the field of nervous systems, and the research and control of genotoxic impurities of the bulk drugs of Flumazenil are hardly reported in China at present. Some of the currently known genotoxic impurities have the disadvantages of low molecular weight, active chemical properties, poor stability and low limit, and the analysis method thereof also faces huge challenges. Therefore, in the production process of flumazenil, the research and control on the genotoxicity of the bulk drug are very important.
Disclosure of Invention
In response to one or more of the deficiencies in the prior art, the present invention provides a flumazenil production system.
In order to solve the above technical problems, the present invention is solved by the following technical solutions.
The flumazenil production process has the following synthetic route:
according to the above synthetic route, it specifically comprises the following steps:
step one, oxidizing 5-fluoroisatin (formula FM-SM1) serving as a raw material in hydrogen peroxide and sulfuric acid to prepare 6-fluoroisatin anhydride (formula FM-1);
step two, reacting the formula FM-1 with sarcosine to obtain the benzodiazepine
Diketones (formula FM-2);
thirdly, reacting the formula FM-2 with phosphorus oxychloride to prepare a formula FM-3;
step four, condensing the formula FM-3 with ethyl isocyanoacetate in an organic solvent to obtain a flumazenil crude product (formula FM-CP);
and step five, refining the flumazenil crude product to obtain flumazenil (formula FM).
Compared with the existing synthetic route taking para-fluoroaniline as the starting material, the production process shortens the synthetic route of the raw material medicine, reduces the introduction risk of genotoxic impurities and improves the production efficiency.
Preferably, step five specifically comprises the steps of,
s1, adding the flumazenil crude product and ethanol into a reaction kettle, heating to dissolve, adding activated carbon, refluxing and decoloring, and carrying out hot filtration;
s2, adding the filtrate in the S1 into another reaction kettle, cooling to room temperature in a gradient manner, then stirring at a constant temperature, cooling to-10 to-5 ℃, crystallizing at a constant temperature, and filtering;
s3, washing the filter residue in the S2 with ethanol, and then blowing and drying to obtain the flumazenil competitive product.
The invention also provides a flumazenil production system which is used for realizing the leaching and drying in the S3 and comprises a refining tank, wherein the refining tank is rotatably arranged on a mounting seat; a cavity is arranged in the refining tank, two partition plates are arranged in parallel in the cavity and used for dividing the cavity into a liquid storage cavity which is positioned at two end parts of the refining tank and used for storing ethanol and a treatment cavity which is positioned in the middle part of the refining tank and used for treating filter residues, and through holes are formed in the middle parts of the partition plates; a material pipe penetrating through the corresponding through hole and extending out of the refining tank is arranged in the treatment cavity, a blocking plate used for being matched with the partition plate to block the through hole is arranged at the end part of the material pipe in the treatment cavity, leak holes are uniformly distributed in the blocking plate, a fixing ring is arranged at the end part of the material pipe extending out of the refining tank, a first spring used for pushing the fixing ring to move upwards to drive the blocking plate to be attached to the partition plate is sleeved on the material pipe extending out of the refining tank, and a blocking mechanism used for blocking the material pipe is arranged in the material pipe; an air drying mechanism used for drying the filter residue is arranged in the treatment cavity.
Through the structure of the invention, the through holes are opened and closed through the movement of the material pipe, so that the ethanol in the upper liquid storage cavity can spray the filter residue in the treatment cavity, after the spraying, the air drying mechanism in the treatment cavity performs blast drying on the filter residue, and further the flumazenil fine product is prepared, and meanwhile, the ethanol in the treatment cavity can be recycled by rotating the refining tank for 180 degrees, and the resources are saved.
Preferably, an annular spring mounting groove is formed in the inner side wall, located in the treatment cavity, of the material pipe along the axial direction of the material pipe, runners communicated with the spring mounting groove are symmetrically arranged in the material pipe along the axial direction of the material pipe, a limiting sliding groove communicated with the interior of the material pipe is formed in the side wall of each runner along the length direction of each runner, a groove communicated with the corresponding runner is formed in the outer end of the material pipe, and a first inclined surface communicated with the outer end of the material pipe is formed in the groove; the blocking mechanism comprises a sealing plate positioned in the treatment cavity and a baffle plate positioned in the material pipe and extending into a spring mounting groove, wherein discharge openings are uniformly distributed on the baffle plate, the sealing plate is connected with the baffle plate through a connecting rod, and a second spring for driving the baffle plate to move and drive the sealing plate to block the material pipe is arranged in the spring mounting groove; a slidable lifting rod is arranged in the walkway, a limiting slide block extending into the corresponding limiting slide groove is arranged on the lifting rod, and a second inclined plane is arranged at the end part of the lifting rod extending out of the walkway; the end part of the refining tank is provided with a mounting plate through a support rod, the mounting plate is provided with a rotatable swivel corresponding to the material cylinder, the swivel is provided with a support rod which extends into the corresponding groove and is used for matching with the first inclined plane to drive the material cylinder to move into the treatment cavity, and the end part of the support rod is provided with a third inclined plane which is used for matching with the second inclined plane to push the lifting rod to move into the running channel.
Through the structure in the invention, the rotation of the rotating ring can respectively realize the opening and closing of the through hole and the opening and closing of the material pipe, so that the leaching of the filter residue by the ethanol and the collection of the ethanol are better facilitated, the recycling and the adding and the discharging of the filter residue in the treatment cavity are facilitated, and the operation is better simple and convenient.
Preferably, the outer side surface of the rotating ring is provided with a first gear, the mounting plate is provided with a first motor, the output shaft of the first motor is provided with a second gear matched with the first gear, and the rotating ring can rotate back and forth to drive the through hole and the material pipe to open and close better.
Preferably, a separating cylinder is arranged between the two clapboards and is used for separating the treatment cavity into an inner cavity and an outer cavity, and air holes are uniformly distributed on the side wall of the separating cylinder and positioned at the two end parts; the air drying mechanism comprises a heating coil pipe which is arranged in the outer cavity and two ends of which extend out of the refining tank, and an air inlet pipe communicated with the outer cavity is arranged outside the refining tank.
Through the structure in the invention, the heat medium generated in the production of flumazenil heats the air entering the inner cavity, and the hot air is preferably formed to blow and dry the filter residue, so that the heat source in the production process is fully utilized, and the flumazenil production system is more energy-saving.
Preferably, a separating ring is arranged in the middle of the outer cavity and is used for separating the outer cavity into an upper outer cavity and a lower outer cavity, and air drying mechanisms are arranged in the upper outer cavity and the lower outer cavity; the middle part department of inner chamber is equipped with the ventilative board, is equipped with the stirring mechanism that is used for carrying out the stirring to the filter residue on the ventilative board.
Through the structure of the invention, hot air entering the inner cavity can penetrate through the air-permeable plate to rise, and filter residues stacked on the air-permeable plate can be preferably subjected to blast drying, so that the drying effect is better.
Preferably, the material turning mechanism comprises material cylinders symmetrically arranged on the breathable plate, a material inlet is formed in the end part, close to the breathable plate, of each material cylinder, a rotating shaft which can rotate and extends out of the corresponding material cylinder is arranged in each material cylinder, a through hole for the rotating shaft to penetrate through is formed in each connecting rod, and a spiral blade is arranged on the rotating shaft in each material cylinder.
Through the structure of the invention, the rotating shaft drives the helical blade to rotate to turn over the filter residue stack on the air permeable plate, and the rising hot air can dry the filter residue better, so that the drying effect of the filter residue is better.
Preferably, the mounting plate is provided with a second motor for driving the corresponding rotating shaft to rotate, so that the rotating shaft can rotate better.
Preferably, the mounting seat comprises a bottom plate, support plates are symmetrically arranged on the bottom plate, hinge holes are symmetrically arranged on the support plates, and arc-shaped sliding grooves are formed in the support plates along the axial direction of the hinge holes; the department is equipped with the articulated shaft that stretches into corresponding hinge hole in the middle part of the refined jar outside, and the refined jar is equipped with the slip post that stretches into in the sliding tray outward, and the screw thread is equipped with the nut that is used for fixed refined jar on the slip post, and the one end that the articulated shaft stretches out the hinge hole is equipped with the third gear, is equipped with the fixed plate in the backup pad, is equipped with the third motor on the fixed plate, is equipped with the fourth gear with third gear matched with on the output shaft of third motor.
Through the structure in the invention, the third motor can preferably drive the third gear to rotate by 180 degrees to and fro by unscrewing the nut, and meanwhile, the position of the refining tank can be fixed by screwing the nut, so that the refining tank is prevented from rotating in the working process.
Drawings
FIG. 1 is a schematic view of a flumazenil production system of example 1;
FIG. 2 is a schematic view of a refining tank in example 1;
FIG. 3 is a schematic sectional view of a refining tank in example 1;
FIG. 4 is a schematic half-sectional view of a refining tank in example 1;
FIG. 5 is a schematic half-section view of a pipe according to example 1;
FIG. 6 is a schematic view of the plugging mechanism in example 1;
FIG. 7 is a schematic structural view of a swivel in embodiment 1;
fig. 8 is a schematic structural view of the mount in embodiment 1.
Detailed Description
For a further understanding of the invention, reference should be made to the following detailed description taken in conjunction with the accompanying drawings and examples. It is to be understood that the examples are illustrative of the invention and not restrictive.
Example 1
The embodiment provides a flumazenil production process, which adopts the following synthetic route:
according to the above synthetic route, the process for producing flumazenil includes the following steps:
step one, oxidizing 5-fluoroisatin (formula FM-SM1) serving as a raw material in hydrogen peroxide and sulfuric acid to prepare 6-fluoroisatin anhydride (formula FM-1);
step two, reacting the 6-fluoroisatoic anhydride with sarcosine to obtain benzodiazepine
Diketones (formula FM-2);
step three, the benzodiazepine
Reacting diketone and phosphorus oxychloride to prepare FM-3;
step four, condensing the formula FM-3 with ethyl isocyanoacetate in an organic solvent to obtain a crude flumazenil product (formula FM-CP);
and step five, refining the flumazenil crude product to obtain flumazenil (formula FM).
In this example, commercially available 5-fluoroisatin was used as a starting material, oxidized to 6-fluoroisatin anhydride, and reacted with sarcosine to obtain benzodiazepine
And the diketone is finally condensed with ethyl isocyanoacetate to obtain flumazenil, compared with the existing reaction route taking para-fluoroaniline as a starting material, the method has the advantages that the process steps are reduced by two steps, the synthesis route of the raw material medicine is shortened, the introduction risk of genotoxic impurities is reduced, and the production efficiency is improved.
In this embodiment, the fifth step specifically includes the following steps,
s1, adding a flumazenil crude product (formula FM-CP) and 95% ethanol into a reaction kettle, heating to dissolve and clear, adding activated carbon, refluxing and decoloring, and performing hot filtration;
s2, adding the filtrate in the S1 into another reaction kettle, cooling to room temperature in a gradient manner, then stirring at a constant temperature, cooling to-10 to-5 ℃, crystallizing at a constant temperature, and filtering;
s3, washing the filter residue in S2 with 95% ethanol, and air-drying to obtain flumazenil competitive product (formula FM).
The embodiment also provides a flumazenil production system, which is used for realizing the leaching and air-blast drying of the filter residue in the S3 and preparing a flumazenil competitive product.
As shown in fig. 1 to 5, the flumazenil production system of the present embodiment includes a cylindrical purification tank 100, wherein the purification tank 100 is rotatably mounted on a mounting base 110; the refining tank 100 is internally provided with a cavity 300, two clapboards 310 are arranged in the cavity 300 in parallel, the clapboards 310 are used for dividing the cavity 300 into a liquid storage cavity 401 which is positioned at two end parts of the refining tank 100 and used for storing ethanol and a treatment cavity which is positioned at the middle part of the refining tank 100 and used for treating filter residue, and the middle part of each clapboard 310 is provided with a through hole 411; a material pipe 320 penetrating through the corresponding through hole 411 and extending out of the refining tank 100 is arranged in the treatment cavity, a blocking plate 510 used for being matched with the partition plate 310 to block the through hole 411 is arranged at the end part of the material pipe 320 in the treatment cavity, leakage holes 511 are uniformly distributed in the blocking plate 510, a fixing ring 520 is arranged at the end part of the material pipe 320 extending out of the refining tank 100, a first spring 321 used for pushing the fixing ring 520 to move upwards to drive the blocking plate 510 to be attached to the partition plate 310 is sleeved on the material pipe 320 extending out of the refining tank 100, and a blocking mechanism used for blocking the material pipe 320 is arranged in the material pipe 320; an air drying mechanism used for drying the filter residue is arranged in the treatment cavity.
Through the structure in the embodiment, the first spring 321 pushes the fixing ring 520 to move so as to drive the blocking plate 510 to be attached to the corresponding partition plate 310, so that the through hole 411 is blocked, and the leakage of ethanol in the liquid storage cavity 401 is avoided; in this embodiment, the refining tank 100 is vertically placed, the filter residue is added into the treatment cavity through the material pipe 320 above, and the filter residue can be stored in the treatment cavity due to the plugging mechanism arranged in the material pipe 320; in this embodiment, the peripheral side surface of the blocking plate 510 is in a close sliding fit with the side wall of the processing cavity, so that the blocking plates 510 on the upper and lower sides move into the processing cavity, and preferably, ethanol in the upper liquid storage cavity 401 can flow into the processing cavity through the leakage hole 511, so that filter residues in the processing cavity are rinsed, and meanwhile, the blocking mechanism blocks the material pipe 320, so that the ethanol is prevented from flowing out of the material pipe 320, so that the ethanol after the filter residues are rinsed can flow into the lower liquid storage cavity 401 for storage, and after the rinsing, the air drying mechanism in the processing cavity air-dries the filter residues, so that the filter residues are dried, and a flumazenil top-quality product is obtained; after the air drying is finished, the plugging mechanism in the material pipe 320 positioned below is opened, so that the flumazenil fine product in the treatment cavity can be discharged. In this embodiment, ethanol is used for leaching impurities on the filter residue, and ethanol leached once can also be reused, and in this embodiment, in order to reuse ethanol repeatedly, the liquid storage cavity 401 for storing ethanol is located above the refining tank 100 again after rotating 180 degrees, and preferably, the filter residue is added from the material pipe 320 above the refining tank again to perform leaching and drying operations again, so that ethanol is reused, and resources are saved; in this embodiment, the refining tank 100 is provided with a liquid inlet pipe 215 communicated with the corresponding liquid storage chamber 401, and ethanol is supplemented into the liquid storage chamber 401 through the liquid inlet pipe 215 and discharged after use.
Referring to fig. 6 to 7, in this embodiment, an annular spring mounting groove 531 is disposed on an inner side wall of the material tube 320 in the processing chamber along an axial direction of the material tube 320, a runner communicated with the spring mounting groove 531 is symmetrically disposed in the material tube 320 along the axial direction of the material tube 320, a limiting chute 534 communicated with the inside of the material tube 320 is disposed on a side wall of the runner along a length direction of the runner, a groove 532 communicated with the corresponding runner is disposed at an outer end of the material tube 320, and a first inclined plane 533 communicated with the outer end of the material tube 320 is disposed in the groove 532; the blocking mechanism comprises a sealing plate 610 positioned in the processing cavity and a baffle 620 positioned in the material pipe 320 and extending into a spring mounting groove 531, discharge openings 621 are uniformly distributed on the baffle 620, the sealing plate 610 is connected with the baffle 620 through a connecting rod 630, and a second spring 540 for driving the baffle 620 to move and drive the sealing plate 610 to block the material pipe 320 is arranged in the spring mounting groove 531; a slidable lifting rod 640 is arranged in the walkway, a limiting slide block 641 extending into the corresponding limiting slide groove 534 is arranged on the lifting rod 640, and a second inclined surface 642 is arranged at the end part of the lifting rod 640 extending out of the walkway; the end of the refining tank 100 is provided with a mounting plate 210 through a support rod 211, the mounting plate 210 is provided with a rotatable swivel 710 corresponding to the material cylinder 320, the swivel 710 is provided with a support rod 720 extending into the corresponding groove 532 and used for cooperating with the first inclined surface 533 to drive the material cylinder 320 to move towards the treatment chamber, and the end of the support rod 720 is provided with a third inclined surface 721 used for cooperating with the second inclined surface 642 to drive the lifting rod 640 to move into the lane.
By the configuration in the embodiment, the second spring 540 pushes the baffle 620 to move towards the interior of the material pipe 320 to drive the sealing plate 610 to block the opening of the material pipe 320; in this embodiment, through the arrangement of the runner, the limiting chute 534, the lifting rod 640 and the limiting slider 641, the limiting slider 641 is located in the limiting chute 534 to slide so that the lifting rod 640 is slidably mounted in the runner, wherein the bottom end of the lifting rod 640 is attached to the baffle 620, so that the second spring 540 pushes the baffle 620 to move towards the interior of the material tube 320 to drive the top end of the lifting rod 640 to extend out of the runner and be located in the groove 532; in this embodiment, an annular mounting groove is formed in the mounting plate 210 corresponding to the material tube 320, a mounting ring 712 extending into the mounting groove is disposed on a side surface of the rotary ring 710, the mounting ring 712 is mounted in the mounting groove through a bearing, and preferably, the rotary ring 710 is rotatably mounted on the mounting plate 210, wherein, by the arrangement of the abutting rod 720, the rotary ring 710 rotates to drive the abutting rod 720 to rotate out or rotate into the groove 532 along the first inclined plane 533, so as to drive the material tube 320 to extend into or extend out of the processing cavity, so as to open or close the through hole 411, and thus, the ethanol in the liquid storage cavity 401 can flow into or flow out of the processing cavity; when the rotary ring 710 rotates to drive the abutting rod 720 to move back and forth in the groove 532, the third inclined surface 721 of the abutting rod 720 and the second inclined surface 642 extrude each other to make the lifting rod 640 retract into the traveling passage to push the baffle 620 to move towards the opening of the material pipe 320 so as to make the sealing plate 610 move down, thereby realizing the opening and closing of the opening of the material pipe 320, wherein the filter residue in the material pipe 320 can enter or be discharged out of the processing chamber through the arrangement of the discharge opening 621. Through the structure in the embodiment, the opening and closing of the through hole and the opening and closing of the material pipe can be respectively realized through the reciprocating rotation of the rotating ring, and the refining operation of the refining tank is better facilitated.
In this embodiment, a first gear 711 is disposed on an outer side surface of the rotating ring 710, a first motor 212 is disposed on the mounting plate 210, and a second gear 212 matched with the first gear 711 is disposed on an output shaft of the first motor 212, so as to preferably realize rotation of the rotating ring 710.
Referring to fig. 4, in the present embodiment, a separating cylinder 330 is disposed between the two partition plates 310, the separating cylinder 330 is used for separating the processing chamber into an inner chamber 402 and an outer chamber 403, and air holes 331 are uniformly disposed on the sidewall of the separating cylinder 330 and at two ends; the air drying mechanism comprises a heating coil 220 which is arranged in the outer cavity 403 and two ends of which extend out of the refining tank 100, and an air inlet pipe 230 which is communicated with the outer cavity is arranged outside the refining tank 100.
Through the structure in the embodiment, the heat medium generated in the flumazenil production process flows through the heating coil 220, wherein air is injected into the outer cavity 403 through the air inlet pipe 230, so that the air injected into the outer cavity 403 can be heated and heated by the heating coil 220, the heated hot air flows into the inner cavity 402 through the air holes 331, filter residues after being showered in the inner cavity 402 are dried by air blowing, and the flumazenil is refined; in this embodiment, during the forced air drying process, the blocking mechanism located above is opened, so as to facilitate the discharge of the steam in the inner cavity 402; through the structure in the embodiment, the heat source generated by the flumazenil production process can be fully utilized, and the flumazenil production system is more energy-saving.
In this embodiment, a separating ring 420 is disposed in the middle of the outer cavity 403, the separating ring 420 is used to separate the outer cavity 403 into an upper outer cavity and a lower outer cavity, and air drying mechanisms are disposed in both the upper outer cavity and the lower outer cavity; the middle part of inner chamber 402 is equipped with ventilative board 340, is equipped with the stirring mechanism that is used for stirring the filter residue on ventilative board 340.
Through the structure in the embodiment, the separating ring 420 and the air-permeable plate 340 divide the inner cavity 402 and the outer cavity 403 into two parts, so that the filter residue added from the upper material pipe 320 is stacked on the air-permeable plate 340, in the embodiment, the air-drying mechanism located below the refining tank 100 works, so that the hot air enters the inner cavity 402 from the air holes 331 at the lower part and rises through the air-permeable plate 340, and the filter residue on the air-permeable plate 340 is preferably dried; in this embodiment, after the refining tank 100 is rotated by 180 °, the fine flumazenil product obtained by drying is discharged from the material pipe 320.
In this embodiment, the material turning mechanism includes material cylinders 430 symmetrically disposed on the air permeable plate 340, a material inlet 431 is disposed at an end of the material cylinder 430 close to the air permeable plate 340, a rotating shaft 341 is disposed in the material cylinder 430 and is rotatable and extends out of the corresponding material pipe 320, a through hole 631 is disposed in the connecting rod 630 for the rotating shaft 341 to pass through, and a helical blade 342 is disposed on the rotating shaft 341 in the material cylinder 430.
Through the structure in this embodiment, make pivot 341 rotate and can drive helical blade 342 and rotate, and then drive the filter residue of filter residue heap bottom and turn to the top of filter residue heap, realize turning of filter residue heap to make the in-process that the hot-air rises dry the filter residue better, make drying effect better.
In this embodiment, the mounting plate 210 is provided with a second motor 214 for driving the corresponding rotating shaft 341 to rotate, so as to preferably realize the rotation of the rotating shaft 341.
As shown in fig. 8, the mounting base 110 includes a bottom plate 810, a support plate 820 is symmetrically disposed on the bottom plate 810, a hinge hole 821 is symmetrically disposed on the support plate 820, and an arc-shaped sliding groove 822 is disposed on the support plate 820 along an axial direction of the hinge hole 821; an articulated shaft 241 extending into the corresponding articulated hole 821 is arranged at the middle part of the outer side of the refined tank 100, a sliding column 242 extending into the sliding groove 822 is arranged outside the refined tank 100, a nut 243 used for fixing the refined tank 100 is arranged on the sliding column 242 in a threaded manner, a third gear 244 is arranged at one end, extending out of the articulated hole 821, of the articulated shaft 241, a fixing plate 823 is arranged on the supporting plate 820, a third motor 830 is arranged on the fixing plate 823, and a fourth gear 831 matched with the third gear 244 is arranged on an output shaft of the third motor 830.
Through the configuration of the present embodiment, the hinge shaft 241 extends into the hinge hole 821 to realize the rotation of the refining tank 100 mounted on the mounting seat 110, wherein the rotation of the refining tank 100 driven by the third motor 830 is preferably realized by the arrangement of the third motor 830, the third gear 244 and the fourth gear 831, wherein the rotation of the refining tank 100 is limited by the sliding of the sliding column 242 in the sliding groove 822 through the arrangement of the sliding groove 822, the sliding column 242 and the nut 243, so that the rotation can only be rotated 180 ° back and forth along the sliding groove 822, and meanwhile, the rotation of the refining tank 100 can be fixed by tightening the nut 243 to avoid the rotation of the refining tank 100 during the operation.
In summary, the above-mentioned embodiments are only preferred embodiments of the present invention, and all equivalent changes and modifications made in the claims of the present invention should be covered by the claims of the present invention.
Claims (8)
1. A flumazenil production system is characterized in that: comprises a refining tank (100), wherein the refining tank (100) is rotatably arranged on a mounting seat (110); a cavity (300) is arranged in the refining tank (100), two partition plates (310) are arranged in the cavity (300) in parallel, the partition plates (310) are used for dividing the cavity (300) into a liquid storage cavity (401) which is positioned at two ends of the refining tank (100) and used for storing ethanol and a treatment cavity which is positioned in the middle of the refining tank (100) and used for treating filter residues, and through holes (411) are formed in the middle of the partition plates (310); a material pipe (320) penetrating through the corresponding through hole (411) and extending out of the refined tank (100) is arranged in the treatment cavity, a blocking plate (510) matched with the partition plate (310) for blocking the through hole (411) is arranged at the end part of the material pipe (320) in the treatment cavity, leakage holes (511) are uniformly distributed in the blocking plate (510), a fixing ring (520) is arranged at the end part of the material pipe (320) extending out of the refined tank (100), a first spring (321) used for pushing the fixing ring (520) to move upwards to drive the blocking plate (510) to be attached to the partition plate (310) is sleeved on the material pipe (320) extending out of the refined tank (100), and a blocking mechanism used for blocking the material pipe (320) is arranged in the material pipe (320); an air drying mechanism used for drying the filter residue is arranged in the treatment cavity.
2. A flumazenil production system according to claim 1, wherein: an annular spring mounting groove (531) is formed in the inner side wall, located in the processing cavity, of the material pipe (320) along the axial direction of the material pipe (320), a runner communicated with the spring mounting groove (531) is symmetrically arranged in the material pipe (320) along the axial direction of the material pipe (320), a limiting sliding groove (534) communicated with the interior of the material pipe (320) is formed in the side wall of the runner along the length direction of the runner, a groove (532) communicated with the corresponding runner is formed in the outer end portion of the material pipe (320), and a first inclined plane (533) communicated with the outer end portion of the material pipe (320) is formed in the groove (532); the blocking mechanism comprises a sealing plate (610) positioned in the processing cavity and a baffle plate (620) positioned in the material pipe (320) and extending into a spring mounting groove (531), discharge openings (621) are uniformly distributed on the baffle plate (620), the sealing plate (610) and the baffle plate (620) are connected through a connecting rod (630), and a second spring (540) for driving the baffle plate (620) to move and driving the sealing plate (610) to block the material pipe (320) is arranged in the spring mounting groove (531); a slidable lifting rod (640) is arranged in the walkway, a limiting sliding block (641) extending into the corresponding limiting sliding groove (534) is arranged on the lifting rod (640), and a second inclined surface (642) is arranged at the end part of the lifting rod (640) extending out of the walkway; the end part of the refining tank (100) is provided with a mounting plate (210) through a support rod (211), the mounting plate (210) is provided with a rotatable swivel (710) corresponding to the material barrel (320), the swivel (710) is provided with a support rod (720) which extends into a corresponding groove (532) and is used for being matched with the first inclined surface (533) to drive the material barrel (320) to move towards the treatment cavity, and the end part of the support rod (720) is provided with a third inclined surface (721) which is used for being matched with the second inclined surface (642) to push the lifting rod (640) to move into the slide way.
3. A flumazenil production system according to claim 2, wherein: a first gear (711) is arranged on the outer side face of the rotating ring (710), a first motor (212) is arranged on the mounting plate (210), and a second gear (212) matched with the first gear (711) is arranged on an output shaft of the first motor (212).
4. A flumazenil production system according to claim 1, wherein: a separating cylinder (330) is arranged between the two partition plates (310), the separating cylinder (330) is used for separating the treatment cavity into an inner cavity (402) and an outer cavity (403), and air holes (331) are uniformly distributed on the side wall of the separating cylinder (330) and positioned at the two end parts; the air drying mechanism comprises a heating coil (220) which is arranged in the outer cavity (403) and two ends of which extend out of the refining tank (100), and an air inlet pipe (230) communicated with the outer cavity is arranged outside the refining tank (100).
5. A flumazenil production system according to claim 4, wherein: a separating ring (420) is arranged in the middle of the outer cavity (403), the separating ring (420) is used for separating the outer cavity (403) into an upper outer cavity and a lower outer cavity, and air drying mechanisms are arranged in the upper outer cavity and the lower outer cavity; the middle part of the inner cavity (402) is provided with a ventilation plate (340), and the ventilation plate (340) is provided with a material turning mechanism for turning the filter residue.
6. A flumazenil production system according to claim 5, wherein: the stirring mechanism comprises material cylinders (430) symmetrically arranged on the air permeable plate (340), a feed inlet (431) is formed in the end part, close to the air permeable plate (340), of each material cylinder (430), a rotating shaft (341) which can rotate and extends out of the corresponding material pipe (320) is arranged in each material cylinder (430), a through hole (631) through which the rotating shaft (341) penetrates is formed in each connecting rod (630), and spiral blades (342) are arranged on the rotating shaft (341) located in each material cylinder (430).
7. The flumazenil production system of claim 6, wherein: the mounting plate (210) is provided with a second motor (214) for driving the corresponding rotating shaft (341) to rotate.
8. A flumazenil production system as in claim 1, wherein: the mounting seat (110) comprises a bottom plate (810), a supporting plate (820) is symmetrically arranged on the bottom plate (810), a hinge hole (821) is symmetrically arranged on the supporting plate (820), and a sliding groove (822) in an arc shape is arranged on the supporting plate (820) along the axial direction of the hinge hole (821); the middle part of the outer side of the refined tank (100) is provided with a hinge shaft (241) extending into the corresponding hinge hole (821), the refined tank (100) is provided with a sliding column (242) extending into a sliding groove (822), the sliding column (242) is provided with a nut (243) used for fixing the refined tank (100) in a threaded manner, one end of the hinge shaft (241) extending out of the hinge hole (821) is provided with a third gear (244), a fixing plate (823) is arranged on the supporting plate (820), a third motor (830) is arranged on the fixing plate (823), and a fourth gear (831) matched with the third gear (244) is arranged on an output shaft of the third motor (830).
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