CN1136815C - Medical laser apparatus and diagnosing/curing apparatus using the medical laser apparatus - Google Patents
Medical laser apparatus and diagnosing/curing apparatus using the medical laser apparatus Download PDFInfo
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- CN1136815C CN1136815C CNB941069079A CN94106907A CN1136815C CN 1136815 C CN1136815 C CN 1136815C CN B941069079 A CNB941069079 A CN B941069079A CN 94106907 A CN94106907 A CN 94106907A CN 1136815 C CN1136815 C CN 1136815C
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(A1 B2) In photodynamic diagnosis and photodynamic therapy, the oscillating wavelength of laser light from a light source is fitted to a plurality of different kinds of photosensitizers and exciting conditions thereof. Moreover, diagnosis and treatment are achieved using concurrent diagnosis during treatment is realized as well. A semiconductor laser generates laser light having an oscillating wavelength which is variable and a full width at half maximum which is narrow. A light transmission line guides an irradiated laser light to the vicinity of a focus, an image transmission line observes the focus and the periphery thereof, a fluorescence light extracting device extracts only the fluorescence light emitted from a photosensitizer excited by the irradiated laser light, an image-pick-up/analyzing device picks up and analyzes an image of the extracted fluorescence light and an image display device displays the analyzing result.
Description
The present invention relates to be used as the medical laser machine of diagnosis/therapy apparatus light source, diagnosis/therapy apparatus makes rayed cure for example focus of tumor such as cancer on focus.The photosensitizer that has affinity interaction with focus is accumulated in the focus in advance, and when the rayed of wavelength and sensitiser absorption consistent wavelength was on focus, photosensitizer was excited, thereby diagnosable and cure focus.The present invention relates to the diagnosis/therapy apparatus that uses the medical laser machine simultaneously.
Recently along with the development of electron medical treatment technology, utilize two kinds of method light power diagnosis methods (below be called the PDD method) of laser and optical dynamic therapy method (below be called the PDT method) to obtain very fast development.PDD method and PDT method specifically are exactly, make in advance and have affinity and display light chemical reaction with tumor for example emitting fluorescence or the photosensitizer of killing cytosis accumulate in the focus of tumor, use the light irradiated lesion then, this irradiation causes that photosensitizer excites, measure emitted fluorescence, can diagnose focus (PDD) in view of the above, or utilize the effect treatment focus (PDT) of killing cell.For effectively exciting photosensitizer, the light wavelength of irradiated lesion is preferably consistent with the absorbing wavelength of photosensitizer, the therefore general light source that adopts lasing light emitter to make irradiated lesion.In this case, LASER Light Source should be fit to the absorbing wavelength of used photosensitizer.
In the diagnosis/therapy apparatus of the treatment cancer of the above-mentioned type, usually use with hemoporphyrin and make photosensitizer and make the dye laser (below be called the quasi-molecule dye laser) of LASER Light Source, as described in Japan Patent publication NO.63-2633 (2633-1988) and the 63-9464 (9464/1988) with excimer laser.Routine diagnosis/the therapy apparatus of publication NO.63-2633 and the disclosed laser instrument of 63-9464 is used in 4 explanations with reference to the accompanying drawings.
Fig. 4 schematically illustrates the formation with the cancer diagnosis/therapy apparatus of conventional laser machine.A is the focus of cancer among Fig. 4, and B represents the peripheral region of focus A, has absorbed the hemoporphyrin as photosensitizer in advance in this zone.First pulse source 31 of diagnosis usefulness and second pulse source 32 of treatment usefulness all are made up of the quasi-molecule dye laser.Excite the quasi-molecule dye laser of first and second dye lasers 31,32 to repeat vibration, oscillation wavelength 308nm, pulse width 30ns, and energy changes in a few milli Jiao to 100 milli Jiao's scope.The oscillation wavelength of first pulse source 31 is 405nm, and the oscillation wavelength of second pulse source 32 is 630nm.First and second pulse sources 31 and 32 usefulness switch blocks, 33 switches.Other numbering, 34 represent optical transmission line; 35 represent television camera; 36 represent TV monitor; 37 represent half-reflecting mirror; 38 represent spectroscope; 39 represent spectroanalysis instrument; 40 represent display.
Diagnosis/the therapy apparatus of above-mentioned formation is operated in the following manner.
When the diagnosis cancer, the wavelength that first light-pulse generator 31 produces is that the laser of 405nm is radiated on focus A and the peripheral region B by switch block 33 and optical transmission line 34.The wavelength that by wavelength is the laser excitation of 405nm be the picture of fluorescence of 630nm, 690nm by television camera 35 shootings, and be presented on the screen of TV monitor 36 so that observation.Simultaneously, by the fluorescence picture of half-reflecting mirror 37 reflection by spectroscope 38 beam split.Spectrum is decomposed in spectrogrph 39, and spectrographic wavelength is shown by display 40.Subsequently, be to cure cancer, the wavelength that is produced by second light-pulse generator 32 is that the laser of 630nm is radiated on the focus A by switch block 33 and optical transmission line 34.Mode of operation switches to diagnostic mode subsequently again to determine the result of treatment.Switch above-mentioned mode of operation repeatedly with aforesaid way and just can diagnose and treat cancer.
Because being the light of 405nm, wavelength can excite the distinctive fluorescence of hemoporphyrin effectively, and because wavelength is 630nm and wavelength is that the wavelength difference of fluorescence of 690nm is big, can limit the adverse effect of scattered light, so the light of first light-pulse generator, the 31 usefulness 405nm wavelength of diagnosis usefulness.The reason that second light-pulse generator 32 of treatment usefulness is set at wavelength 630nm is that wavelength is that the laser of 630nm can effectively absorb through tissue and by hemoporphyrin well.
Except that above-mentioned example and, below listed the photosensitizer that proposes to be used in PDD and the PDT method in the table 1, also show the laser of just managing in the table as PDT method LASER Light Source.
Table 1
| Photosensitizer | Absorbing wavelength (nm) | LASER Light Source (emission wavelength (nm)) | The shortcoming of laser instrument |
| HpD | ?630 | The quasi-molecule dye laser, argon dye laser (624 ± 6.5nm) golden vapor lasers (627.8nm) | Coloring matter solution is rotten fast; Volume is big, and price is expensive to be needed more than the preheating 30min; Gas and resonant cavity life-span are short; Volume is big, and price is expensive |
| PH-1126 | ?650 | Krypton laser (647nm) | The gas life-span is short; Volume is big, the price duty |
| NPe6 | ?664 | Argon dye laser (667+5nm) | Coloring matter solution is rotten fast; Volume is big, |
The shortcoming of conventional cancer diagnosis/therapy apparatus is that the wavelength of emitted laser is difficult to control.
In other words, need make the consistent wavelength of the absorption band of Wavelength of Laser and photosensitizer, thereby excite photosensitizer effectively.Usually, gas laser (table 1) can not satisfy the absorption band of many photosensitizer.Worse is, gas laser be difficult to have with in addition a kind of corresponding to wavelength of maximum absorption wavelength of photosensitizer.As described in according to above-mentioned conventional example,,, need to change coloring matter solution in order to change the oscillation wavelength of dye laser though dye laser has been used to address this problem.Therefore, should prepare many laser, change Wavelength of Laser if desired, for example when changing the photosensitizer that uses corresponding to many variety classes coloring matter solution, or, then change laser to each wavelength when Wavelength of Laser during from wavelength during to treatment of the wavelength shift in when diagnosis.
Using under the situation of dye laser, for the solution that holds many kinds of coloring matters and the switching part of solution, diagnosis/therapy apparatus becomes excessive dimensionally and becomes shortcoming.
The coloring matter solution that second shortcoming using the diagnosis/therapy apparatus of dye laser is dye laser is apt to deteriorate, causes the change of optical maser wavelength of generation or the reduction of output.In order to guarantee the PDD method, the effect of PDT method particularly, the safety of laser is most important and essential condition, so the solution that a big problem of dye laser is a coloring matter must often change, the blood circulation of coloring matter must often be cleaned.In addition, if the solution of using in dye laser is degraded easily, then undesirable change takes place in optical maser wavelength between the light period, or laser output reduces, promptly should be according to above-mentioned consideration according to wavelength and this variation of the output irradiation that comes setting laser, and arrange the change of detection laser.
The 3rd, when dye laser conversion wavelength, the full width at half maximum (FWHM) degree of gained optical maser wavelength is widened a little, and at least about 10nm, if the full width at half maximum (FWHM) degree has been widened, then laser strengthens the absorption band skew of photosensitizer, has therefore worsened the launching efficiency of photosensitizer.Though can utilize band pass filter or diffraction grating to reduce the full width at half maximum (FWHM) degree of dye laser, only can cut unnecessary part, launching efficiency still can not get improving.
When the 4th shortcoming was the wavelength conversion, the energy conversion efficiency of dye laser was poor.Therefore, for the laser from conversion obtains enough energy, require output height as the excimer laser of light source activation dye laser etc.In other words, conventional medical laser machine and use the cancer diagnosis/therapy apparatus of the conventional medical laser machine volume that becomes easily big, price is expensive.
Inherent the 5th shortcoming of prior art is and to treat two light sources with diagnosis, and the switching part used of toggle lights.Therefore machine is huge, costs an arm and a leg, and in addition, the toggle lights inconvenience is also worried maloperation.
In order to eliminate the shortcoming of above-mentioned conventional machine, the low medical laser machine of price that the purpose of this invention is to provide a kind of compactness, this machine can obtain oscillation wavelength and can cooperate with many kinds of photosensitizer, the also laser that cooperates with its many shooting conditions, and maintenance easily, the full width at half maximum (FWHM) degree is narrow, launching efficiency is high.
Another object of the present invention provides a kind of diagnosis/therapy apparatus that uses this medical laser machine, and this machine has been realized diagnosis and treatment with a single light source, therefore can diagnose simultaneously during treating.
In order to realize these and other objects, according to a first aspect of the present invention, a kind of medical laser machine is provided, focus is diagnosed or treated to the rayed that this machine utilizes light source to send on focus, accumulate the photosensitizer that affinity is arranged with focus in advance in the focus zone, photosensitizer is excited, this machine comprises as the laser instrument of light source and is used to control the Wavelength of Laser control device, this laser instrument can be controlled oscillation wavelength, the full width at half maximum (FWHM) degree of laser is narrower than the width of bands of a spectrum, in this bands of a spectrum zone, the energy absorption of photosensitizer is equal to or greater than near peaked 90% of oscillation wavelength.
According to a second aspect of the present invention, a kind of diagnosis/therapy apparatus is provided, focus is diagnosed or treated to the rayed that this machine utilizes light source to send on focus, accumulate the photosensitizer that affinity is arranged with focus in advance in the focus zone, photosensitizer is excited, this diagnosis/therapy apparatus comprises the medical laser machine, optical transmission line, the picture transmission line, fluorescence segregation apparatus and picture collection/analytical equipment, the medical laser machine comprises as the laser instrument of light source again and is used to control the Wavelength of Laser control device, this laser instrument can be controlled oscillation wavelength, the full width at half maximum (FWHM) degree of laser is narrower than the width of bands of a spectrum, in this bands of a spectrum zone, the energy absorption of photosensitizer is equal to or greater than near peaked 90% of this oscillation wavelength; The laser aiming that optical transmission line sends the medical laser machine is near focus; Image transmission system be used to transmit with laser excitation by the photosensitizer emitted fluorescence, so that observation focus and all around; The fluorescence segregation apparatus only is used to separate fluorescence; Picture collection/analytical equipment is used to gather and analyze the picture of the fluorescence that is obtained by the fluorescence segregation apparatus.
A kind of medical laser machine, focus is diagnosed or treated to the method that on the laser irradiation focus of this machine utilization with light emitted the photosensitizer (6) in the focus is excited, the photosensitizer that has affinity with focus accumulates in the focus in advance, this machine comprises as the laser instrument of light source and control Wavelength of Laser control device (8), this laser instrument can be controlled oscillation wavelength, and the full width at half maximum (FWHM) degree of laser is narrower than the width of an absorption band, in this absorption band zone, the energy absorption of photosensitizer is equal to or greater than near peaked 90% the oscillation wavelength.
A kind of diagnosis/therapy apparatus, focus is diagnosed or treated to this machine utilization with the method that the light emitted laser irradiation makes the photosensitizer (6) in the focus excite on focus, and this photosensitizer and focus have affinity, accumulate in advance in the focus, and this diagnosis/therapy apparatus comprises:
Medical laser machine (21), this laser machine comprises the semiconductor laser of using as light source and is used to control the wavelength control device of this semiconductor laser, wherein, this wavelength control device is the Temperature-controlled appliance that is used to control this semiconductor laser actuator temperature, and this semiconductor laser can be controlled oscillation wavelength, and the full width at half maximum (FWHM) degree of laser is narrower than the width of an absorption band, and in this absorption band zone, the energy absorption of photosensitizer is equal to or greater than near peaked 90% the oscillation wavelength;
Optical transmission line (22) is used for medical laser machine emitted laser is transferred near the focus;
Picture transmission line (23) is used to transmit the photosensitizer emitted fluorescence of laser excitation, so as observation focus and focus around;
Fluorescence segregation apparatus (27) is used for only fluorescence being told;
Picture collection/analytical equipment (25) is used to gather and analyze the fluorescence picture of telling with the fluorescence segregation apparatus.
Describe in conjunction with most preferred embodiment with reference to the accompanying drawings, can understand these and other purpose of the present invention and feature thus.
Fig. 1 is a block chart, and the composition of the medical laser machine of first embodiment of the invention is shown;
Fig. 2 is a block chart, and the composition of the diagnosis/therapy apparatus of second embodiment of the invention is shown;
Fig. 3 is a band pass filter performance plot used in the second embodiment of the invention;
Fig. 4 is a block chart, and the composition with the cancer diagnosis/therapy apparatus of conventional laser machine is shown.
Before explanation the present invention, it should be noted that in institute's drawings attached, identical parts are represented with identical numbering.
The medical laser machine of first embodiment of the invention is discussed with reference to the accompanying drawings.
The composition of the medical laser machine of the first embodiment of the present invention is shown in Fig. 1.With reference to Fig. 1, ALGaInP semiconductor laser 1 guarantees that oscillation wavelength is 664nm, and the full width at half maximum (FWHM) degree is ± 1nm, and the temperature profile of oscillation wavelength is 0.2nm/ ℃, and during 0 ℃ of excitation, exercisable temperature range is from-100 ℃ to+80 ℃.Optical system 2 is divided into irradiating laser 3a and wavelength detection laser 3b with semiconductor laser 1 emitted laser 3.Photosensitizer 6 is supplied with the target part to be treated 5 that comprises focus A and focus A peripheral regions B in advance.Other numbering, 4 expression optical fiberss, 7 represent control device, 8 expression temperature control equipments, the wavelength checkout gear of 9 expression detection laser 3b wavelength, 10 expression wavelength display devices, 11 expression shutters combine formation irradiation interrupting device automatically with control device 7.
The following describes the operation of the medical laser machine that as above constitutes.
Wavelength by semiconductor laser 1 emitted laser 3 can be measured according to the temperature of semiconductor laser 1.That is, when the temperature of semiconductor laser 1 utilized temperature control equipment 8 to change in-100 ℃ to+80 ℃ scope, the wavelength of laser 3 changed in 644nm to 680nm scope.Thereby can obtain being suitable for wavelength used photosensitizer 6 absorbing wavelength and that be suitable for the laser 3 of therapeutic purposes.
In the present embodiment, the NPe6 of the chlorin family in the application table 1 (trade name of Japan petroleum chemistry company limited) makes photosensitizer 6.When require wavelength be photosensitizer 6 from the laser 3 of the centre wavelength 664nm of 660nm to 680nm absorption band the time, the temperature of semiconductor laser 1 is set at 0 ℃.On the other hand, based on the laser of following purpose for shorter wavelength 660nm in the band that is absorbed, the temperature of semiconductor laser 1 is controlled in-15 ℃.The PH-1126 of the phoeophorbide family in application table 1 (trade name of Hamari chemicals company limited), when requirement obtained laser 3 centre wavelength 650nm and shorter wavelength 644nm from 647nm to the 653nm absorption band, semiconductor laser should be controlled at-70 ℃ and-100 ℃ respectively.The full width at half maximum (FWHM) degree is narrower than the width of absorption band, and in the absorption band zone, the energy absorption of photosensitizer is equal to or greater than near peaked 90% of oscillation wavelength.
Because the full width at half maximum (FWHM) degree is ± 1nm, so being controlled at the wavelength of semiconductor laser 1 emitted laser 3 of 0 ℃ of temperature ,-15 ℃ ,-70 ℃ and-100 ℃ is 663～665nm, 659～661nm, 649～651nm and 643～645nm, promptly the energy of laser 3 remains in the absorption band of used photosensitizer 6.
A part of laser 3 of controlled semiconductor laser instrument 1 emission is told by optical system 2, and 3b guides to wavelength checkout gear 9 as the wavelength detection laser.The wavelength of checkout gear 9 detection laser 3b.Testing result is sent to control device 7.Whether 7 decision laser 3b are consistent with the predetermined condition of its wavelength of control for control device.Testing result and wavelength value are shown by wavelength display device 10.Control device 7 with under the situation of expectant control term harmonization starts working automatic irradiation shutter 11 at laser 3b, thereby closes irradiating laser 3a.
When laser 3 and expectant control term harmonization, shutter 11 is opened, and irradiation swashs first 3a and entered optical fibers 4 by optically focused, penetrates from the end of optical fibers 4 then to be radiated in the target portion 5.
As mentioned above, the oscillation wavelength that can control laser obtains its narrow wavelength of full width at half maximum (FWHM) degree and is fit to the absorbing wavelength of many photosensitizer and the laser that can be used for treating, thereby photosensitizer can effectively be excited.In addition, the laser machine almost can not keep in repair, compact dimensions, and price is low.
Following cancer diagnosis/therapy apparatus with reference to Fig. 2 and 3 explanation second embodiment of the invention.
Fig. 2 is a block chart, and the formation of the cancer diagnosis/therapy apparatus of second embodiment of the invention is shown.Among Fig. 2, Ref. No. 21 expression LASER Light Sources, this light source is the medical laser machine that adopts semiconductor laser among above-mentioned first embodiment, 22 expression optical transmission lines, the irradiating laser 3a that penetrates by LASER Light Source 21 by this transmission line guide to focus near, 23 the expression as transmission line, the fluorescence picture transmits as transmission line by this, thus may observe focus and focus around.The light pipe 24 that comprises optical transmission line 22 and picture transmission line 23 is with near two transmission lines 22 and the 23 guiding focuses.Picture collection/analytical equipment 25 is gathered near the picture of focus and is divided exploring by picture transmission line 23.Analysis result is presented in the picture display device 26.Be rather narrow i.e. band pass filter from pact ± 3nm to specified wavelength 27 of bandwidth is formed (for example, the interference light filter of the dielectric completely DIF of Japanese vacuum Optical Co., Ltd has characteristic shown in Figure 3) by dielectric multilayer film.27 of band pass filters allow the light of the contiguous wavelength of used photosensitizer fluorescence wavelength to pass through, and separate with irradiating laser 3a.When using chlorin family photosensitizer, be about 670nm by wavelength, when using phoeophorbide family photosensitizer, be about 654nm by wavelength.Band pass filter 27 places and makes as on transmission line 23 and the optical axis that is connected of picture collection/analytical equipment 25.It should be noted that band pass filter 27 can load onto many bandpass filters corresponding to many photosensitizer respectively, also can load onto the switching device shifter (not shown) that switches bandpass filter.Remaining Ref. No. is identical parts among 5 grades representatives and Fig. 1 for example.
The following describes the operation of the cancer diagnosis/therapy apparatus that constitutes by above-mentioned configuration.
At first, the irradiating laser 3a of LASER Light Source 21 emissions is radiated on the target part 5 by optical transmission line 22, in target part 5, has accumulated photosensitizer in advance.At this moment, laser 3a is subjected to the control of temperature device and has the centre wavelength of sensitiser absorption band, thereby treatment produces optimum efficiency.In other words, when using NPe6 and PH-1126 to make photosensitizer, the wavelength of laser 3a is controlled to be 664nm and 650nm respectively.Be illustrated among control operation first embodiment in front.
When laser 3a was radiated on the target part 5, owing to accumulate in the effect of photosensitizer wherein in advance, focus A was treated selectively.Simultaneously, the photosensitizer in focus A is subjected to exciting of laser 3a, launches the fluorescence of specific wavelength subsequently as previously mentioned.Therefore the picture of analysis of fluorescence can be diagnosed target part 5.The wavelength of fluorescence quite approaches the wavelength of irradiating laser 3a, and a little less than the fluorescence intensity, so fluorescence is subjected to the influence of the scattered light of laser 3a strongly.Thereby collection and analysis of fluorescence are as being very difficult with conventional method.
Therefore in the present embodiment, make by fluorescence and pass band pass filter 27 as transmission line 23.Specifically, make fluorescence by having the band pass filter 27 of Fig. 3 illustration characteristic, this light filter only allows used photosensitizer emitted fluorescence to pass through, and elimination irradiating laser 3a, thereby can eliminate the influence of the scattered light of laser 3a.The result has only the picture of fluorescence to be input to picture collection/analytical equipment 25.Picture collections/analytical equipment 25 is gathered and the picture data of analysis of fluorescence, and its result is presented at and looks like display device 26 for example on the TV and by recording equipment VTR (magnetic tape video recorder) record for example.Observe to show image, just can real-time diagnosis focus A, even in therapeutic process.
For the separation degree of the scattered light (N) that improves fluorescence (S) and irradiating laser 3a (S/N than), can also be with respect to the wavelength control of fluorescence and the wavelength of mobile irradiating laser 3a.Promptly can control irradiating laser 3a, make its wavelength from the centre wavelength of used sensitiser absorption band (for example when adopting NPe6 or PH-1126, centre wavelength is 664nm or 650nm) move away wavelength of fluorescence in the absorption band (for example adopt NPe6 or PH～1126 o'clock, 660nm or 644nm).If control the wavelength of irradiating laser in a manner described, then can improve signal to noise ratio S/N.Simultaneously, because the energy of irradiating laser 3a still as before described in first embodiment, remaining in the absorption band of photosensitizer, so therapeutic effect is influenced hardly.
Also can make the oscillation wavelength of laser 3 in the diagnosis/therapy apparatus that only adopts specific photosensitizer (for example NPe6 or PH-1126) (for example is that 664 ± 5nm or 650 ± 10nm) changes under the situation of NPe6 or PH-1126 in effective absorption band scope of photosensitizer.
Because in the medical laser machine of the embodiment of the invention, can easily control the wavelength of irradiating laser 3a, even so do not need to diagnose simultaneously and treat, also the wavelength of irradiating laser 3a can be rotated back into the centre wavelength of sensitiser absorption band, promptly forward best treatment wavelength to.In addition, an advantage of the medical laser machine of the foregoing description is whether the wavelength that can show laser 3 meets controlled condition.If the wavelength and the controlled condition of laser 3 are inconsistent, then laser is cut off as previously mentioned.
Therefore, owing in the diagnosis/therapy apparatus of the foregoing description, disposed band pass filter, therefore can diagnose simultaneously and treat with a LASER Light Source.Wavelength of Laser can and move apart photosensitizer emitted fluorescence wavelength in the sensitiser absorption band by wavelength control device control, thus diagnose at the same time and treat during can reach the signal to noise ratio S/N that guarantees image stabilization.
Though the laser instrument in first embodiment is a semiconductor laser, as long as the full width at half maximum (FWHM) degree is narrow, the oscillation wavelength of laser can change, and also can adopt the laser instrument of other type.Certainly, semiconductor laser 1 is not limited to have the laser instrument in characteristic described in first embodiment.For example, can assemble external resonance type semiconductor laser, this optical maser wavelength can be controlled from its outside change resonance.
In addition, though in first embodiment, adopt wavelength checkout gear 9 with feedback controling mode control temperature, if but utilize the storage arrangement that concerns between the oscillation wavelength stored used semiconductor laser and the temperature and control the temperature of semiconductor laser according to this relation, then also can correctly control wavelength.
As the detailed description that this paper front is done, the medical laser machine is equipped with as the laser instrument of LASER Light Source and Wavelength of Laser control device.The narrow laser of this laser instrument emission full width at half maximum (FWHM) degree, and the oscillation wavelength of this laser is adjustable.Therefore this medical laser machine can reach and make oscillation wavelength be suitable for the photosensitizer of used type and the shooting condition of photosensitizer, thereby can effectively excite photosensitizer.In addition, the medical laser machine is also advantageous in that maintenance hardly, compactness and price are low.
According to diagnosis/therapy apparatus of the present invention because the fluorescence picture is being also shown in during the focus in the picture display device in treatment, so can diagnose focus and treat with a single light source, and during treating with simple and compact device diagnosis focus.Diagnosis/therapy apparatus processing ease.
Though proved absolutely the present invention in conjunction with most preferred embodiment with reference to accompanying drawing, should be noted that for the present technique professional, obviously can carry out variations and modifications.This variation and modification are appreciated that and are included in the scope of the present invention that appended claims narrates, unless these variations and modification have surmounted this scope.
Claims (13)
1. medical laser machine, focus is diagnosed or treated to the method that on the laser irradiation focus of this machine utilization with light emitted the photosensitizer (6) in the focus is excited, the photosensitizer that has affinity with focus accumulates in the focus in advance, this machine comprises as the semiconductor laser of light source and control Wavelength of Laser control device (8), wherein, this wavelength control device is the Temperature-controlled appliance of this semiconductor laser actuator temperature of control, and this laser instrument can be controlled oscillation wavelength, and the full width at half maximum (FWHM) degree of laser is narrower than the width of an absorption band, in this absorption band zone, the energy absorption of photosensitizer is equal to or greater than near peaked 90% the oscillation wavelength.
2. medical laser machine as claimed in claim 1, it is characterized in that this machine also comprises the wavelength checkout gear (9) that is used to detect semiconductor laser emitted laser wavelength, thereby can utilize the temperature of wavelength control device control semiconductor laser according to the testing result of wavelength checkout gear.
3. a medical laser machine as claimed in claim 1 is characterized in that this machine is equipped with a storage device, in order to the temperature of storing semiconductor laser instrument and the relation between the wavelength, thereby can be according to the temperature of this relation control semiconductor laser.
4. medical laser machine as claimed in claim 1, it is characterized in that this machine also comprises control device (7) and wavelength display device (10), control device be used to judge the wavelength of semiconductor laser emitted laser and wavelength value whether with the wavelength control term harmonization; The wavelength display device is used for the judgement of display control unit output.
5. medical laser machine as claimed in claim 1, it is characterized in that this machine also comprises control device (7) and shines shutter device (7 automatically, 11), control device be used to judge the wavelength of semiconductor laser emitted laser and wavelength value whether with the wavelength control term harmonization; When semiconductor laser emitted laser wavelength and wavelength control condition were inconsistent, this shines shutter device automatically closed, and does not pass through irradiating laser.
6. a medical laser machine as claimed in claim 1 is characterized in that, the photosensitizer that has affinity with focus is the chlorin photosensitizer, and in this laser machine, optical maser wavelength is adjustable and is controlled in 664 ± 5nm scope.
7. a medical laser machine as claimed in claim 1 is characterized in that, the photosensitizer that has affinity with focus is the phoeophorbide photosensitizer, and in this laser machine, optical maser wavelength is adjustable and is controlled in 650 ± 10nm scope.
8. diagnosis/therapy apparatus, focus is diagnosed or treated to this machine utilization with the method that the light emitted laser irradiation makes the photosensitizer (6) in the focus excite on focus, this photosensitizer and focus have affinity, accumulate in advance in the focus, and this diagnosis/therapy apparatus comprises:
Medical laser machine (21), this laser machine comprises the semiconductor laser of using as light source and is used to control the wavelength control device of this semiconductor laser, wherein, this wavelength control device is the Temperature-controlled appliance that is used to control this semiconductor laser actuator temperature, and this semiconductor laser can be controlled oscillation wavelength, and the full width at half maximum (FWHM) degree of laser is narrower than the width of an absorption band, and in this absorption band zone, the energy absorption of photosensitizer is equal to or greater than near peaked 90% the oscillation wavelength;
Optical transmission line (22) is used for medical laser machine emitted laser is transferred near the focus;
Picture transmission line (23) is used to transmit the photosensitizer emitted fluorescence of laser excitation, so as observation focus and focus around;
Fluorescence segregation apparatus (27) is used for only fluorescence being told;
Picture collection/analytical equipment (25) is used to gather and analyze the fluorescence picture of telling with the fluorescence segregation apparatus.
9. diagnosis/therapy apparatus as claimed in claim 8, it is characterized in that this machine also comprises is used to show the picture display device (26) as analysis result of fluorescence that picture collections/analytical equipment obtains, thereby can use during the treatment focus as display device demonstration fluorescence picture.
10. a diagnosis/therapy apparatus as claimed in claim 8 is characterized in that, the fluorescence segregation apparatus is a band pass filter, and it allows fluorescence to pass, the laser of elimination irradiation.
11. diagnosis/therapy apparatus as claimed in claim 9, it is characterized in that, when utilizing the fluorescence that shows to look like to carry out the focus diagnosis when carrying out focus treatment, the wavelength control device can make Wavelength of Laser move apart photosensitizer emitted fluorescence wavelength in the sensitiser absorption band.
12. diagnosis/therapy apparatus as claimed in claim 10, it is characterized in that, the photosensitizer that has affinity with focus is the chlorin photosensitizer, optical maser wavelength is adjustable and be controlled in 664 ± 5nm scope in this machine, and band pass filter is the band pass filter by wavelength 670nm and elimination wavelength 660nm.
13. a diagnosis/therapy apparatus as claimed in claim 10, it is characterized in that, the photosensitizer that has affinity with focus is the phoeophorbide photosensitizer, optical maser wavelength is adjustable and be controlled in 650 ± 10nm scope in this machine, and band pass filter is the band pass filter by wavelength 654nm and elimination wavelength 644nm.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5209325A JP2596221B2 (en) | 1992-12-28 | 1993-08-24 | Medical laser device and diagnostic / therapy device |
| JP209325/1993 | 1993-08-24 | ||
| JP209325/93 | 1993-08-24 |
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| Publication Number | Publication Date |
|---|---|
| CN1100619A CN1100619A (en) | 1995-03-29 |
| CN1136815C true CN1136815C (en) | 2004-02-04 |
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| CNB941069079A Expired - Lifetime CN1136815C (en) | 1993-08-24 | 1994-06-02 | Medical laser apparatus and diagnosing/curing apparatus using the medical laser apparatus |
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| CN103815964A (en) * | 2014-03-20 | 2014-05-28 | 熊力 | Multi-functional operating knife |
| DE102014016990B3 (en) * | 2014-11-18 | 2016-02-11 | Wavelight Gmbh | Nozzle unit for cross-linking of eye tissue |
| CN108371756B (en) * | 2018-02-10 | 2024-01-30 | 中国医学科学院生物医学工程研究所 | Diagnosis and treatment integrated cervical lesion photodynamic therapy system |
-
1994
- 1994-06-02 CN CNB941069079A patent/CN1136815C/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103536355A (en) * | 2013-08-21 | 2014-01-29 | 熊力 | Tumor targeted non-destructive low-power laser multi-functional scalpel system |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1100619A (en) | 1995-03-29 |
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