CN1136815C - Medical laser apparatus and diagnosing/curing apparatus using the medical laser apparatus - Google Patents

Abstract

A diagnostic/therapeutic machine that can realize simultaneous diagnosis during treatment has a medical laser machine (21) that uses a semiconductor laser as a light source. The laser light produced by the laser light source has a narrow half-maximum full width and an adjustable oscillation wavelength. The diagnosis/treatment machine also has an optical transmission line 22) for transmitting the irradiation laser 3a emitted by the medical laser machine (21) to the vicinity of the lesion (5), an image transmission line (23) for observing the lesion (5) and its surroundings, A fluorescence separation device (27) for separating only the fluorescence emitted from the photosensitizer excited by the irradiated laser light (3a), an image collection/analysis device (25) for collecting and analyzing the fluorescence image obtained by the fluorescence separation device, and an image for displaying the analysis result Display device (26).

Description

Medical laser machines and diagnostic/therapeutic machines using the same

The present invention relates to a medical laser machine used as a light source of a diagnosis/treatment machine which irradiates light on a lesion to treat a lesion of a tumor such as cancer. The photosensitizer that has an affinity with the lesion is accumulated in the lesion in advance, and when the light with the same wavelength as the absorption wavelength of the photosensitizer is irradiated on the lesion, the photosensitizer is stimulated, so the lesion can be diagnosed and treated. The invention also relates to diagnostic/therapeutic machines using medical laser machines.

Recently, with the development of electronic medical technology, two methods using laser light, photodynamic diagnosis (hereinafter referred to as PDD method) and photodynamic therapy (hereinafter referred to as PDT method), have been rapidly developed. Specifically, the PDD method and the PDT method are to gather in the lesion of the tumor a photosensitizer that has an affinity with the tumor and exhibits a photochemical reaction, such as emitting fluorescence or killing cells, and then irradiates the lesion with light, which causes the photosensitizer to be excited. , to measure the emitted fluorescence, according to which the lesion can be diagnosed (PDD), or the lesion can be treated by killing cells (PDT). In order to effectively excite the photosensitizer, the wavelength of the light irradiating the lesion should preferably be consistent with the absorption wavelength of the photosensitizer, so a laser source is generally used as the light source for irradiating the lesion. In this case, the laser light source should be suitable for the absorption wavelength of the photosensitizer used.

A dye laser (hereinafter referred to as an excimer dye laser) using hematoporphyrin as a photosensitizer and an excimer laser as a laser light source is often used in the above-mentioned type of diagnostic/therapeutic machine for treating cancer, as described in Japanese Patent Publication No. 63-2633 (2633-1988) and 63-9464 (9464/1988). A conventional diagnosis/treatment machine using the laser disclosed in Publication Nos. 63-2633 and 63-9464 will be described below with reference to FIG. 4 .

Fig. 4 schematically shows the constitution of a cancer diagnosis/treatment machine using a conventional laser machine. In Fig. 4, A is the focus of cancer, and B is the area around the focus A, where hematoporphyrin as a photosensitizer has been absorbed in advance. Both the first pulse source 31 for diagnosis and the second pulse source 32 for treatment are composed of excimer dye lasers. The excimer dye laser that excites the first and second dye lasers 31, 32 repeatedly oscillates, the oscillation wavelength is 308 nm, the pulse width is 30 ns, and the energy varies in the range of several millijoules to 100 millijoules. The oscillation wavelength of the first pulse source 31 is 405 nm, and the oscillation wavelength of the second pulse source 32 is 630 nm. The first and second pulse sources 31 and 32 are switched by the switching means 33 . For other numbers, 34 represents the optical transmission line; 35 represents the TV camera; 36 represents the TV monitor; 37 represents the half mirror; 38 represents the beam splitter; 39 represents the spectrum analyzer; 40 represents the display.

The diagnosis/treatment machine constructed as described above operates in the following manner.

When diagnosing cancer, laser light with a wavelength of 405 nm generated by the first pulse light source 31 is irradiated on the lesion A and the surrounding area B through the switch part 33 and the optical transmission line 34 . Images of fluorescent light with wavelengths of 630 nm and 690 nm excited by laser light with a wavelength of 405 nm are captured by a television camera 35 and displayed on the screen of a television monitor 36 for observation. At the same time, the fluorescent image reflected by the half mirror 37 is split by the beam splitter 38 . The spectrum is resolved in a spectrometer 39 and the wavelengths of the spectrum are displayed by a display 40 . Subsequently, in order to treat cancer, the laser light with a wavelength of 630 nm generated by the second pulse light source 32 is irradiated on the lesion A through the switch part 33 and the optical transmission line 34 . The working mode then switches to the diagnostic mode to determine the outcome of the treatment. Cancer can be diagnosed and treated by repeatedly switching the above-mentioned working mode in the above-mentioned way.

Because the light with a wavelength of 405nm can effectively excite the unique fluorescence of hematoporphyrin, and because the wavelength difference between the fluorescence with a wavelength of 630nm and that with a wavelength of 690nm is large, the harmful effects of scattered light can be limited, so the first pulse light source for diagnosis 31 Use light with a wavelength of 405nm. The reason why the second pulse light source 32 for treatment is set at a wavelength of 630nm is that laser light with a wavelength of 630nm can penetrate tissues well and be effectively absorbed by hematoporphyrin.

In addition to the above examples, photosensitizers that have been proposed for use in PDD and PDT methods are listed in Table 1 below, which also shows lasers that are being tried to be used as laser light sources for PDT methods.

Table 1 Photosensitizer Absorption wavelength(nm) Laser light source (emission wavelength (nm)) Disadvantages of Lasers HpD 630 Excimer dye laser, argon dye laser (624±6.5nm) gold vapor laser (627.8nm) The colored substance solution deteriorates quickly; the volume is large and expensive PH-1126 650 Krypton laser (647nm) The gas life is short; the volume is large and the price is responsible NPe6 664 Argon dye laser (667+5nm) The colored substance solution deteriorates quickly; the volume is large,

A disadvantage of conventional cancer diagnosis/treatment machines is that it is difficult to control the wavelength of emitted laser light.

In other words, it is necessary to match the wavelength of laser light with the wavelength of the absorption band of the photosensitizer to efficiently excite the photosensitizer. In general, it is not possible for gas lasers (Table 1) to satisfy the absorption bands of many photosensitizers. Worse, it is difficult for a gas laser to have a wavelength that coincides with the maximum absorption wavelength of even a photosensitizer. As described in accordance with the above-mentioned conventional examples, although dye laser light has been used to solve this problem, in order to change the oscillation wavelength of the dye laser light, it is necessary to change the colored substance solution. Therefore, many lasers corresponding to many different kinds of colored substance solutions should be prepared, and if the wavelength of the laser needs to be changed, for example, when the photosensitizer used is changed, or when the wavelength of the laser is changed from a diagnostic wavelength to a therapeutic wavelength, then Convert laser light to each wavelength.

In the case of using a dye laser, in order to accommodate solutions of many kinds of colored substances and switching parts for the solutions, the diagnostic/therapeutic machine becomes excessively large in size to be disadvantageous.

A second disadvantage of a diagnostic/therapeutic machine using a dye laser is that the colored substance solution of the dye laser is easily deteriorated, causing a change in the wavelength of the generated laser light or a decrease in output. In order to ensure the effect of the PDD method, especially the PDT method, the safety of the laser is the most important and indispensable condition, so a big problem with the dye laser is that the solution of the colored substance must be replaced frequently, and the circulation system of the colored substance must be cleaned frequently . In addition, if the solution used in the dye laser is easily degraded, the wavelength of the laser light changes undesirably during irradiation, or the output of the laser light decreases, that is, the irradiation of the laser light should be set according to such changes in wavelength and output in consideration of the above, And arrange to detect the change of the laser light.

Third, when the wavelength of the dye laser is converted, the full width at half maximum of the obtained laser wavelength is slightly widened, at least about 10nm. If the full width at half maximum is widened, the absorption band shift of the laser to the photosensitizer will increase, so the deterioration The excitation efficiency of the photosensitizer. Although band-pass filters or diffraction gratings can be used to reduce the full width at half maximum of the dye laser, the excess part can only be cut off, and the excitation efficiency still cannot be improved.

The fourth disadvantage is the poor energy conversion efficiency of dye lasers during wavelength conversion. Therefore, in order to obtain sufficient energy from the converted laser light, the output of an excimer laser or the like used as a light source to excite dye laser light is required to be high. In other words, conventional medical laser machines and cancer diagnosis/treatment machines using the conventional medical laser machines tend to become bulky and expensive.

A fifth disadvantage inherent in the prior art is the necessity of both diagnostic and therapeutic light sources, as well as switching components for switching the light sources. Therefore, the machine is huge and expensive. In addition, it is inconvenient to switch the light source, and there is also concern about misoperation.

In order to eliminate the disadvantages of the above-mentioned conventional machines, the object of the present invention is to provide a compact and low-cost medical laser machine, which can obtain lasers with oscillation wavelengths that can be matched with many photosensitizers and many excitation conditions, and can be easily maintained. Easy, narrow full width at half maximum, high excitation efficiency.

Another object of the present invention is to provide a diagnosis/treatment machine using such a medical laser machine, which realizes diagnosis and treatment with a single light source, so that diagnosis can be performed simultaneously during treatment.

In order to achieve these and other objects, according to the first aspect of the present invention, a medical laser machine is provided, which uses the light emitted by the light source to irradiate the lesion on the lesion to diagnose or treat the lesion, and pre-stores in the lesion area a photosensitive laser that has an affinity for the lesion. agent, whereby the photosensitizer is excited, the machine includes a laser used as a light source and a wavelength control device for controlling the laser, the laser can control the oscillation wavelength, the full width at half maximum of the laser is narrower than the width of a spectral band, in which The band region where the energy absorption of the photosensitizer is equal to or greater than 90% of the maximum near the oscillation wavelength.

According to the second aspect of the present invention, a diagnosis/treatment machine is provided, which uses the light emitted by the light source to irradiate the lesion on the lesion for diagnosis or treatment, and pre-stores a photosensitizer that has an affinity with the lesion in the lesion area, thereby making the photosensitizer Agent excitation, the diagnosis/treatment machine includes a medical laser machine, optical transmission line, image transmission line, fluorescence separation device and image acquisition/analysis device, and the medical laser machine includes a laser used as a light source and a wavelength control device for controlling the laser. The laser can control the oscillation wavelength. The half-maximum full width of the laser is narrower than the width of a band. In this band region, the energy absorption of the photosensitizer is equal to or greater than 90% of the maximum value close to the oscillation wavelength; the optical transmission line will be medical laser The laser emitted by the machine is guided to the vicinity of the lesion; the image transmission system is used to transmit the fluorescence emitted by the photosensitizer excited by the laser, so as to observe the lesion and its surroundings; the fluorescence separation device is only used to separate the fluorescence; the image acquisition/analysis device is used for The fluorescence image obtained by the fluorescence separation device is collected and analyzed.

A medical laser machine, which diagnoses or treats the lesion by irradiating the laser light emitted by the light source on the lesion to excite the photosensitizer (6) in the lesion. Comprising a laser as a light source and a wavelength control device (8) for controlling the laser, the laser can control the oscillation wavelength, and the half-maximum full width of the laser is narrower than the width of an absorption band, and in the absorption band region, the energy absorption of the photosensitizer is equal to Or more than 90% of the maximum value near the oscillation wavelength.

A diagnosis/treatment machine, which diagnoses or treats a lesion by irradiating a light source with laser light on the lesion to excite a photosensitizer (6) in the lesion. The photosensitizer has an affinity with the lesion and is pre-accumulated in the lesion, This diagnostic/therapeutic unit includes:

A medical laser machine (21), which includes a semiconductor laser used as a light source and a wavelength control device for controlling the semiconductor laser, wherein the wavelength control device is a temperature control device for controlling the temperature of the semiconductor laser, and the The semiconductor laser can control the oscillation wavelength, and the half-maximum full width of the laser is narrower than the width of an absorption band. In the absorption band region, the energy absorption of the photosensitizer is equal to or greater than 90% of the maximum value near the oscillation wavelength;

Optical transmission line (22), used for transmitting the laser light emitted by the medical laser machine to the vicinity of the lesion;

Like a transmission line (23), it is used to transmit the fluorescence emitted by the photosensitizer excited by the laser, so as to observe the lesion and its surroundings;

Fluorescence separation device (27), used to separate only fluorescence;

An image collection/analysis device (25), used for collecting and analyzing the fluorescent images separated by the fluorescence separation device.

These and other objects and features of the present invention will be apparent from the following description of preferred embodiments with reference to the accompanying drawings.

Fig. 1 is a block diagram showing the composition of the medical laser machine of the first embodiment of the present invention;

Fig. 2 is a block diagram showing the composition of a diagnosis/treatment machine of a second embodiment of the present invention;

Fig. 3 is a characteristic diagram of the bandpass filter used in the second embodiment of the present invention;

Fig. 4 is a block diagram showing the composition of a cancer diagnosis/treatment machine using a conventional laser machine.

Before describing the present invention, it should be noted that throughout the drawings, like parts are represented by like numerals.

A medical laser machine according to a first embodiment of the present invention will be discussed below with reference to the accompanying drawings.

The composition of the medical laser machine of the first embodiment of the present invention is shown in FIG. 1 . Referring to Figure 1, the ALGaInP semiconductor laser 1 guarantees an oscillation wavelength of 664nm, a full width at half maximum of ±1nm, and a temperature characteristic of the oscillation wavelength of 0.2nm/°C. During excitation at 0°C, the operable temperature range is from -100°C to + 80°C. Optical system 2 divides laser light 3 emitted from semiconductor laser 1 into irradiation laser light 3a and wavelength detection laser light 3b. The photosensitizer 6 is supplied in advance to the target portion 5 to be treated including the lesion A and the area B around the lesion A. For other numbers, 4 represents the optical fiber, 7 represents the control device, 8 represents the temperature control device, 9 represents the wavelength detection device for detecting the wavelength of the laser light 3b, 10 represents the wavelength display device, and 11 represents the shutter, which is combined with the control device 7 to form an automatic irradiation interruption device.

The operation of the medical laser machine constructed as above will be described below.

The wavelength of laser light 3 emitted from semiconductor laser 1 can be measured from the temperature of semiconductor laser 1 . That is, when the temperature of the semiconductor laser 1 is changed within the range of -100°C to +80°C using the temperature control device 8, the wavelength of the laser light 3 is changed within the range of 644nm to 680nm. Thus, a wavelength of the laser light 3 suitable for the absorption wavelength of the photosensitizer 6 used and suitable for the therapeutic purpose can be obtained.

In this embodiment, NPe6 (trade name of Nippon Petrochemical Co., Ltd.) of the chlorophyllin family in Table 1 was used as the photosensitizer 6 . When the laser light 3 having a wavelength of 664 nm, which is the center wavelength of the absorption band from 660 nm to 680 nm of the photosensitizer 6, is required, the temperature of the semiconductor laser 1 is set at 0°C. On the other hand, the temperature of the semiconductor laser 1 is controlled at -15° C. for the purpose of obtaining laser light with a shorter wavelength of 660 nm in the absorption band for the following purpose. When using the PH-1126 (trade name of Hamari Chemicals Co., Ltd.) of the pheophorbide family in Table 1, when requiring to obtain from 647nm to the laser light 3 of the center wavelength 650nm of the 653nm absorption band and the shorter wavelength 644nm, Semiconductor lasers should be controlled at -70°C and -100°C respectively. The full width at half maximum is narrower than the width of the absorption band in which the energy absorption of the photosensitizer is equal to or greater than 90% of the maximum near the oscillation wavelength.

Because the full width at half maximum is ±1nm, the wavelengths of the laser light 3 emitted by the semiconductor laser 1 controlled at temperatures of 0°C, -15°C, -70°C and -100°C are 663-665nm, 659-661nm, 649-651nm and 643-645nm, that is, the energy of the laser light 3 is kept within the absorption band of the photosensitizer 6 used.

Part of the laser light 3 emitted by the controlled semiconductor laser 1 is separated by the optical system 2, and guided to the wavelength detection device 9 as wavelength detection laser light 3b. The detection device 9 detects the wavelength of the laser light 3b. The detection result is sent to the control device 7 . The control means 7 decides whether or not the laser light 3b agrees with a predetermined condition controlling its wavelength. The detection result and the wavelength value are displayed by the wavelength display device 10 . The control device 7 activates the automatic irradiation shutter 11 to turn off the irradiation laser 3 a when the laser beam 3 b does not match a predetermined control condition.

When the laser light 3 is consistent with the predetermined control condition, the shutter 11 is opened, and the irradiation laser 3a is focused into the optical fiber 4, and then emitted from the end of the optical fiber 4 to irradiate the target portion 5.

As described above, the oscillation wavelength of the laser light can be controlled to obtain a laser light having a narrow full width at half maximum whose wavelength is suitable for the absorption wavelength of many photosensitizers and which can be used for treatment, so that the photosensitizers can be efficiently excited. In addition, the laser machine is almost maintenance-free, compact in size, and low in price.

A cancer diagnosis/treatment machine according to a second embodiment of the present invention will be described below with reference to FIGS. 2 and 3. FIG.

Fig. 2 is a block diagram showing the constitution of a cancer diagnosis/treatment machine of a second embodiment of the present invention. In Fig. 2, reference number 21 represents laser light source, and this light source is to adopt the medical laser machine of semiconductor laser in the above-mentioned first embodiment, and 22 represents optical transmission line, and the irradiation laser light 3a that emits by laser light source 21 is led to the vicinity of lesion by this transmission line , 23 represents the image transmission line through which the fluorescent image is transmitted, so that the lesion and its surroundings can be observed. The light guiding device 24 including the light transmission line 22 and the image transmission line 23 guides the two transmission lines 22 and 23 to the vicinity of the lesion. The image collection/analysis device 25 collects images near the lesion through the image transmission line 23 and analyzes the images. Analysis results are displayed on the image display device 26 . The band-pass filter 27 having a relatively narrow bandwidth, that is, from about ±3 nm to a specified wavelength, is composed of a dielectric multilayer film (for example, the complete dielectric interference filter DIF of Japan Vacuum Optical Co., Ltd. has the characteristics shown in FIG. 3 ) . The band-pass filter 27 allows only light of a wavelength close to the fluorescence wavelength of the photosensitizer used to pass through, and separates it from the irradiating laser light 3a. When a photosensitizer of the chlorophyllide family is used, the passing wavelength is about 670nm, and when a pheophytin family photosensitizer is used, the passing wavelength is about 654nm. A bandpass filter 27 is placed on the optical axis connecting the image transmission line 23 and the image acquisition/analysis device 25 . It should be noted that the band-pass filter 27 can be equipped with a plurality of band-pass filters corresponding to a plurality of photosensitizers, or a switching device (not shown) for switching the band-pass filters. The remaining reference numerals such as 5 etc. denote the same components as in FIG. 1 .

The operation of the cancer diagnosis/treatment machine configured as above will be explained below.

First, the irradiation laser light 3a emitted from the laser light source 21 is irradiated through the optical transmission line 22 onto the target portion 5 in which the photosensitizer is accumulated in advance. At this time, the laser 3a is controlled by the temperature device to have the central wavelength of the absorption band of the photosensitizer, so that the treatment produces the best effect. In other words, when NPe6 and PH-1126 were used as photosensitizers, the wavelength of the laser light 3a was controlled to be 664nm and 650nm, respectively. The control operation has been explained in the foregoing first embodiment.

When the laser light 3a is irradiated on the target portion 5, the lesion A is selectively treated due to the action of the photosensitizer previously accumulated therein. At the same time, the photosensitizer in the lesion A is excited by the laser light 3a, and then emits fluorescence of a specific wavelength as described above. Analyzing the fluorescent image can therefore diagnose the target portion 5 . The wavelength of the fluorescence is quite close to the wavelength of the irradiated laser light 3a, and the intensity of the fluorescence is weak, so the fluorescence is strongly affected by the scattered light of the laser light 3a. Therefore, it is generally difficult to collect and analyze fluorescence images by conventional methods.

Therefore, in this embodiment, the fluorescent light passing through the image transmission line 23 is passed through the band-pass filter 27 . Specifically, the fluorescent light is passed through a band-pass filter 27 having the characteristics illustrated in FIG. 3, which only allows the fluorescent light emitted by the photosensitizer used to pass through, and filters out the irradiation laser light 3a, thereby eliminating the effect of scattered light of the laser light 3a. Influence. As a result, only the fluorescent image is input to the image acquisition/analysis device 25 . The image collection/analysis device 25 collects and analyzes fluorescent image data, and the result is displayed on an image display device 26 such as a TV and recorded by a recording device such as a VTR (Video Tape Recorder). By observing the displayed image, the lesion A can be diagnosed in real time, even during the treatment.

In order to improve the degree of separation (S/N ratio) of the fluorescence (S) from the scattered light (N) of the irradiation laser light 3a, it is also possible to control and shift the wavelength of the irradiation laser light 3a relative to the wavelength of the fluorescence. That is, the irradiation laser 3a can be controlled so that its wavelength moves from the central wavelength of the absorption band of the photosensitizer used (for example, when using NPe6 or PH-1126, the central wavelength is 664nm or 650nm) to move away from the fluorescence wavelength in the absorption band (such as using NPe6 or PH-1126). PH～1126, 660nm or 644nm). If the wavelength of the irradiating laser light is controlled as described above, the signal-to-noise ratio S/N can be improved. Meanwhile, since the energy of the irradiating laser light 3a remains within the absorption band of the photosensitizer as previously described in the first embodiment, the therapeutic effect is hardly affected.

In diagnostic/therapeutic machines that only use a specific photosensitizer (such as NPe6 or PH-1126), the oscillation wavelength of the laser 3 can also be made within the effective absorption band range of the photosensitizer (such as 664 in the case of NPe6 or PH-1126). ±5nm or 650±10nm) change.

Because the wavelength of the irradiation laser 3a can be easily controlled in the medical laser machine of the embodiment of the present invention, even if it is not necessary to perform diagnosis and treatment at the same time, the wavelength of the irradiation laser 3a can be turned back to the central wavelength of the absorption band of the photosensitizer, That is to switch to the optimal therapeutic wavelength. In addition, one advantage of the medical laser machine in the above embodiment is that it can display whether the wavelength of the laser light 3 meets the control conditions. If the wavelength of the laser light 3 does not match the control conditions, the laser light is cut off as described above.

Therefore, since the band-pass filter is provided in the diagnosis/treatment machine of the above-mentioned embodiment, it is possible to simultaneously perform diagnosis and treatment with one laser light source. The wavelength of the laser can be controlled by the wavelength control device to move away from the fluorescence wavelength emitted by the photosensitizer in the absorption band of the photosensitizer, so that the signal-to-noise ratio S/N that ensures image stability can be achieved during simultaneous diagnosis and treatment.

Although the laser in the first embodiment is a semiconductor laser, as long as the full width at half maximum is narrow, the oscillation wavelength of the laser can be changed, and other types of lasers can also be used. Of course, the semiconductor laser 1 is not limited to the laser having the characteristics described in the first embodiment. For example, it is possible to assemble an external resonance type semiconductor laser whose laser wavelength can be controlled by changing the resonance from the outside.

In addition, although in the first embodiment, the temperature is controlled by the feedback control method using the wavelength detecting device 9, if the memory device which stores the relationship between the oscillation wavelength and the temperature of the semiconductor laser used is used and the semiconductor laser is controlled based on this relationship temperature, the wavelength can also be correctly controlled.

As described in detail earlier herein, a medical laser machine is equipped with a laser used as a laser light source and a wavelength control device for the laser. The laser emits laser light with a narrow half-maximum full width, and the oscillation wavelength of the laser light is adjustable. Therefore, the medical laser machine can achieve an oscillation wavelength suitable for the type of photosensitizer used and the excitation conditions of the photosensitizer, thereby effectively exciting the photosensitizer. In addition, the advantages of medical laser machines are that they are almost maintenance-free, compact and inexpensive.

According to the diagnosis/treatment machine of the present invention, since the fluorescent image is also displayed on the image display device during the treatment of the lesion, it is possible to diagnose and treat the lesion with a single light source, and to diagnose the lesion during the treatment with a simple and compact device . The diagnosis/treatment machine is easy to operate.

Although the present invention has been fully described with reference to the preferred embodiments thereof with reference to the accompanying drawings, it should be noted that various changes and modifications will be apparent to those skilled in the art. Such changes and modifications should be understood to be included within the scope of the present invention described in the appended claims, unless these changes and modifications go beyond this scope.

Claims (13)

1. A kind of medical laser machine, this machine utilizes the method that the photosensitizer (6) in the lesion is excited by the laser that light source emits is irradiated on the lesion to diagnose or treat the lesion, and the photosensitizer that has affinity with the lesion is accumulated in the lesion in advance, The machine includes a semiconductor laser as a light source and a wavelength control device (8) for controlling the laser, wherein the wavelength control device is a temperature control device for controlling the temperature of the semiconductor laser, and the laser can control the oscillation wavelength, and the full half-maximum value of the laser The width is narrower than the width of an absorption band in the region where the energy absorption of the photosensitizer is equal to or greater than 90% of the maximum value near the oscillation wavelength. 2. a medical laser machine as claimed in claim 1, is characterized in that this machine also comprises the wavelength detection device (9) that is used to detect the laser wavelength that semiconductor laser device emits, thereby can according to the detection result of wavelength detection device, utilize The wavelength control device controls the temperature of the semiconductor laser. 3. A medical laser machine as claimed in claim 1, characterized in that the machine is equipped with a storage device for storing the relationship between the temperature of the semiconductor laser and the wavelength, so that the temperature of the semiconductor laser can be controlled according to this relationship. temperature. 4. A medical laser machine as claimed in claim 1, characterized in that the machine also includes a control device (7) and a wavelength display device (10), and the control device is used to determine the wavelength and a wavelength of the laser light emitted by the semiconductor laser Whether the value is consistent with the wavelength control condition; the wavelength display device is used to display the judgment of the output of the control device. 5. A medical laser machine as claimed in claim 1, characterized in that the machine also includes a control device (7) and an automatic irradiation shutter device (7, 11), and the control device is used to determine the wavelength of the laser light emitted by the semiconductor laser And whether a wavelength value is consistent with the wavelength control condition; when the laser wavelength emitted by the semiconductor laser is not consistent with the wavelength control condition, the automatic irradiation shutter device is closed and the laser is not irradiated. 6. A medical laser machine as claimed in claim 1, characterized in that, the photosensitizer having affinity with the lesion is a chlorophyllin photosensitizer, and in this laser machine, the laser wavelength is adjustable and controlled at 664±5nm range. 7. A medical laser machine as claimed in claim 1, characterized in that, the photosensitizer having affinity with the lesion is a pheophorbide photosensitizer, and in this laser machine, the laser wavelength is adjustable and controlled In the range of 650±10nm. 8. A diagnosis/treatment machine, which diagnoses or treats lesions by emitting laser light from a light source on the lesions to excite the photosensitizer (6) in the lesions. The photosensitizer has an affinity with the lesions and is accumulated in the lesions , the diagnosis/treatment machine includes: A medical laser machine (21), which includes a semiconductor laser used as a light source and a wavelength control device for controlling the semiconductor laser, wherein the wavelength control device is a temperature control device for controlling the temperature of the semiconductor laser, and the The semiconductor laser can control the oscillation wavelength, and the half-maximum full width of the laser is narrower than the width of an absorption band. In the absorption band region, the energy absorption of the photosensitizer is equal to or greater than 90% of the maximum value near the oscillation wavelength; Optical transmission line (22), used for transmitting the laser light emitted by the medical laser machine to the vicinity of the lesion; Like a transmission line (23), it is used to transmit the fluorescence emitted by the photosensitizer excited by the laser, so as to observe the lesion and its surroundings; Fluorescence separation device (27), used to separate only fluorescence; An image collection/analysis device (25), used for collecting and analyzing the fluorescent images separated by the fluorescence separation device. 9. A diagnosis/treatment machine as claimed in claim 8, characterized in that the machine also includes an image display device (26) for displaying the fluorescence image analysis results obtained by the image acquisition/analysis device, thus during the treatment of lesions Fluorescent images can be displayed with an image display device. 10. A diagnostic/therapeutic machine as claimed in claim 8, wherein the fluorescence separating means is a band-pass filter which allows the fluorescence to pass through and filters the irradiated laser light. 11. A diagnosis/treatment machine as claimed in claim 9, characterized in that, when the focus is being treated and the displayed fluorescent image is used for focus diagnosis, the wavelength control device can make the wavelength of the laser shift away from the area where the photosensitizer absorbs. The wavelength of fluorescence emitted by the photosensitizer within the band. 12. A diagnosis/treatment machine as claimed in claim 10, characterized in that the photosensitizer having affinity with the lesion is a chlorophyllin photosensitizer, and the laser wavelength is adjustable and controlled within the range of 664±5nm in the machine Inside, the bandpass filter is a bandpass filter that passes a wavelength of 670nm and filters out a wavelength of 660nm. 13. A diagnosis/treatment machine as claimed in claim 10, characterized in that the photosensitizer having affinity with the lesion is a pheophorbide photosensitizer, and the laser wavelength is adjustable and controlled at 650±10nm in the machine In the range, the bandpass filter is a bandpass filter that passes a wavelength of 654nm and filters out a wavelength of 644nm.

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