CN113679881A - Medical dressing with antibacterial property and preparation method thereof - Google Patents
Medical dressing with antibacterial property and preparation method thereof Download PDFInfo
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0014—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
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- A—HUMAN NECESSITIES
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/008—Hydrogels or hydrocolloids
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- A—HUMAN NECESSITIES
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L2300/104—Silver, e.g. silver sulfadiazine
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
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Abstract
The invention relates to a medical dressing with antibacterial property and a preparation method thereof, aiming at improving the antibacterial property of lignin/chitosan/PVA hydrogel medical dressing in the prior art, antibacterial metal nano particles are doped into the hydrogel medical dressing, and researches show that the antibacterial property of the medical dressing can be obviously improved along with the improvement of the content of the antibacterial particles, and the antibacterial property of metal silver is more excellent than that of metal zinc. Moreover, under certain conditions, the two antibacterial metal particles can also play a role in synergy, and further achieve an unexpected antibacterial effect.
Description
Technical Field
The invention relates to the field of medical dressings, in particular to a medical dressing with antibacterial performance and a preparation method thereof.
Background
The skin damage of human body can be divided into two types of damage with tissue defect and damage without tissue defect, and the medical dressing is a medical product for skin damage. The traditional medical dressing (natural gauze) has the advantages of strong capability of absorbing wound seepage liquid and relatively simple production and processing processes, but the permeability is too high, the early wound is easily dehydrated to deepen the wound, the mechanical injury can be caused again during replacement, the risk of later-stage blood stasis formation is increased due to injury, and when the seepage liquid permeates the full-layer gauze, microorganisms in the external environment can easily pass through, so that higher infection risk exists. In response to this problem, developers have developed various medical dressings, such as foam type, film type, hydrogel type, hydrocolloid type, and the like. The hydrogel type medical dressing has the advantages of softness, good elasticity, no toxic or side effect, air permeability, water permeability and the like, and is widely applied to wound care processes of skin wounds, skin ulcers, burns, scalds and the like.
The Zhangyian prepares a lignin/chitosan/PVA hydrogel medical dressing in the text of 'preparation and performance research of lignin-based wound dressings', in the dressing, with the increase of lignin content, the performances such as hydrophilic performance, protein adsorption capacity, cell activity and the like can be obviously improved, however, the anion group in the lignin can neutralize the cation group of chitosan, so that the antibacterial performance of the lignin/chitosan/PVA hydrogel medical dressing is not ideal under the condition of higher lignin content.
Disclosure of Invention
Aiming at the problems in the prior art, the invention aims to provide a preparation method of a medical dressing with antibacterial property, and the method can greatly improve the antibacterial property of lignin/chitosan/PVA hydrogel medical dressing in the prior art.
A preparation method of a medical dressing with antibacterial performance is characterized by comprising the following steps:
A. dissolving 4-6g of chitosan in 36-40mL of acetic acid solution, and uniformly stirring to obtain a chitosan solution X;
B. dissolving 8-10g of PVA in 32-40g of deionized water, and stirring at 80-90 ℃ for 30-60min to obtain a PVA solution Y;
C. dissolving lignosulfonate in deionized water, and uniformly stirring to obtain lignosulfonate solution Z;
D. dispersing the nano metal particles in 10g of deionized water to form nano metal particle dispersion liquid;
E. and D, respectively taking 10g of solution X, Y, Z, mixing with the nano metal dispersion liquid obtained in the step D, stirring for 5-8h, pouring into a mold, freezing for 8-10h at-18 ℃, then unfreezing at room temperature, and repeating for 5-8 times to obtain the hydrogel medical dressing.
Further, the volume concentration of the acetic acid solution is 2%.
Further, the concentration of the lignosulfonate solution was 30 wt%.
Further, the nano metal particles are silver or zinc.
Further, the nano metal particles are silver and zinc.
Further, the dosage of the nano metal particles is 0.29g-0.62 g.
Further, the mass of silver was 0.33g, and the mass of zinc was 0.29 g.
The invention also provides a medical dressing with antibacterial performance, which is prepared by the method.
In order to improve the antibacterial performance of lignin/chitosan/PVA hydrogel medical dressing in the prior art, the antibacterial metal nanoparticles are doped into the hydrogel medical dressing, and researches show that the antibacterial performance of the medical dressing can be obviously improved along with the improvement of the content of the antibacterial particles, and the antibacterial performance of metal silver is more excellent than that of metal zinc. Moreover, under certain conditions, the two antibacterial metal particles can also play a role in synergy, and further achieve an unexpected antibacterial effect.
Detailed Description
The technical effects of the present invention are demonstrated below by specific examples, but the embodiments of the present invention are not limited thereto.
Example 1
A. Dissolving 4g of chitosan in 36mL of 2% acetic acid solution by volume concentration, and uniformly stirring to obtain a chitosan solution X;
B. dissolving 8g of PVA in 32g of deionized water, and stirring at 90 ℃ for 30min to obtain a PVA solution Y;
C. dissolving 3g of lignosulfonate in 7g of deionized water, and uniformly stirring to obtain lignosulfonate solution Z;
D. dispersing 0.33g of nano-silver into 10g of deionized water to form nano-silver dispersion liquid;
E. and D, respectively taking 10g of solution X, Y, Z, mixing with the nano metal dispersion liquid obtained in the step D, stirring for 5 hours, pouring into a mold, freezing for 8 hours at-18 ℃, then unfreezing at room temperature, and repeating for 5 times to obtain the hydrogel medical dressing.
Example 2
A. Dissolving 4g of chitosan in 36mL of 2% acetic acid solution by volume concentration, and uniformly stirring to obtain a chitosan solution X;
B. dissolving 8g of PVA in 32g of deionized water, and stirring at 90 ℃ for 30min to obtain a PVA solution Y;
C. dissolving 3g of lignosulfonate in 7g of deionized water, and uniformly stirring to obtain lignosulfonate solution Z;
D. dispersing 0.29g of nano zinc in 10g of deionized water to form nano zinc dispersion;
E. and D, respectively taking 10g of solution X, Y, Z, mixing with the nano metal dispersion liquid obtained in the step D, stirring for 5 hours, pouring into a mold, freezing for 8 hours at-18 ℃, then unfreezing at room temperature, and repeating for 5 times to obtain the hydrogel medical dressing.
Example 3
A. Dissolving 4g of chitosan in 36mL of 2% acetic acid solution by volume concentration, and uniformly stirring to obtain a chitosan solution X;
B. dissolving 8g of PVA in 32g of deionized water, and stirring at 90 ℃ for 30min to obtain a PVA solution Y;
C. dissolving 3g of lignosulfonate in 7g of deionized water, and uniformly stirring to obtain lignosulfonate solution Z;
D. dispersing 0.62g of nano-silver into 10g of deionized water to form nano-silver dispersion liquid;
E. and D, respectively taking 10g of solution X, Y, Z, mixing with the nano metal dispersion liquid obtained in the step D, stirring for 5 hours, pouring into a mold, freezing for 8 hours at-18 ℃, then unfreezing at room temperature, and repeating for 5 times to obtain the hydrogel medical dressing.
Example 4
A. Dissolving 4g of chitosan in 36mL of 2% acetic acid solution by volume concentration, and uniformly stirring to obtain a chitosan solution X;
B. dissolving 8g of PVA in 32g of deionized water, and stirring at 90 ℃ for 30min to obtain a PVA solution Y;
C. dissolving 3g of lignosulfonate in 7g of deionized water, and uniformly stirring to obtain lignosulfonate solution Z;
D. dispersing 0.62g of nano zinc in 10g of deionized water to form nano zinc dispersion;
E. and D, respectively taking 10g of solution X, Y, Z, mixing with the nano metal dispersion liquid obtained in the step D, stirring for 5 hours, pouring into a mold, freezing for 8 hours at-18 ℃, then unfreezing at room temperature, and repeating for 5 times to obtain the hydrogel medical dressing.
Example 5
A. Dissolving 4g of chitosan in 36mL of 2% acetic acid solution by volume concentration, and uniformly stirring to obtain a chitosan solution X;
B. dissolving 8g of PVA in 32g of deionized water, and stirring at 90 ℃ for 30min to obtain a PVA solution Y;
C. dissolving 3g of lignosulfonate in 7g of deionized water, and uniformly stirring to obtain lignosulfonate solution Z;
D. dispersing 0.29g of nano-silver into 10g of deionized water to form nano-silver dispersion liquid;
E. and D, respectively taking 10g of solution X, Y, Z, mixing with the nano metal dispersion liquid obtained in the step D, stirring for 5 hours, pouring into a mold, freezing for 8 hours at-18 ℃, then unfreezing at room temperature, and repeating for 5 times to obtain the hydrogel medical dressing.
Example 6
A. Dissolving 4g of chitosan in 36mL of 2% acetic acid solution by volume concentration, and uniformly stirring to obtain a chitosan solution X;
B. dissolving 8g of PVA in 32g of deionized water, and stirring at 90 ℃ for 30min to obtain a PVA solution Y;
C. dissolving 3g of lignosulfonate in 7g of deionized water, and uniformly stirring to obtain lignosulfonate solution Z;
D. dispersing 0.33g of nano zinc in 10g of deionized water to form nano zinc dispersion;
E. and D, respectively taking 10g of solution X, Y, Z, mixing with the nano metal dispersion liquid obtained in the step D, stirring for 5 hours, pouring into a mold, freezing for 8 hours at-18 ℃, then unfreezing at room temperature, and repeating for 5 times to obtain the hydrogel medical dressing.
Example 7
A. Dissolving 4g of chitosan in 36mL of 2% acetic acid solution by volume concentration, and uniformly stirring to obtain a chitosan solution X;
B. dissolving 8g of PVA in 32g of deionized water, and stirring at 90 ℃ for 30min to obtain a PVA solution Y;
C. dissolving 3g of lignosulfonate in 7g of deionized water, and uniformly stirring to obtain lignosulfonate solution Z;
D. dispersing 0.33g of nano silver and 0.29g of nano zinc in 10g of deionized water to form nano silver-zinc dispersion liquid;
E. and D, respectively taking 10g of solution X, Y, Z, mixing with the nano metal dispersion liquid obtained in the step D, stirring for 5 hours, pouring into a mold, freezing for 8 hours at-18 ℃, then unfreezing at room temperature, and repeating for 5 times to obtain the hydrogel medical dressing.
Example 8
A. Dissolving 4g of chitosan in 36mL of 2% acetic acid solution by volume concentration, and uniformly stirring to obtain a chitosan solution X;
B. dissolving 8g of PVA in 32g of deionized water, and stirring at 90 ℃ for 30min to obtain a PVA solution Y;
C. dissolving 3g of lignosulfonate in 7g of deionized water, and uniformly stirring to obtain lignosulfonate solution Z;
D. dispersing 0.29g of nano silver and 0.33g of nano zinc in 10g of deionized water to form nano silver-zinc dispersion liquid;
E. and D, respectively taking 10g of solution X, Y, Z, mixing with the nano metal dispersion liquid obtained in the step D, stirring for 5 hours, pouring into a mold, freezing for 8 hours at-18 ℃, then unfreezing at room temperature, and repeating for 5 times to obtain the hydrogel medical dressing.
Comparative example
A. Dissolving 4g of chitosan in 36mL of 2% acetic acid solution by volume concentration, and uniformly stirring to obtain a chitosan solution X;
B. dissolving 8g of PVA in 32g of deionized water, and stirring at 90 ℃ for 30min to obtain a PVA solution Y;
C. dissolving 3g of lignosulfonate in 7g of deionized water, and uniformly stirring to obtain lignosulfonate solution Z;
D. respectively taking 10g of solution X, Y, Z, mixing and stirring for 5h, pouring into a mold, freezing at-18 ℃ for 8h, then unfreezing at room temperature, and repeating for 5 times to obtain the hydrogel medical dressing.
The following test specimens were subjected toThe antibacterial performance of the product is evaluated by the following specific method: concentration of the selected bacterial liquid is 4X 107The bacterial liquid for test (cfu/ml) of Staphylococcus aureus was added to the surface of the sample in an amount of 0.2ml, and the mixture was treated at 37 ℃ and RH>Culturing for 48h under 90% condition, taking out samples, counting viable bacteria, and obtaining the antibacterial rate by counting as shown in table 1.
TABLE 1 antibacterial Properties of the respective test samples
From table 1, it can be seen that the antibacterial performance of the lignin/chitosan/PVA hydrogel medical dressing can be significantly improved by adding nano metallic silver and/or zinc, and the antibacterial performance and the addition amount of the metal particles are in a positive correlation trend. In addition, we have surprisingly found that at a particular added amount of antimicrobial particles (as in example 7), the antimicrobial properties of the medical dressing are unexpectedly superior, and it is likely that under this particular system, a synergistic effect of unknown principle occurs between the two metal particles.
It is worth mentioning that the invention specially selects the bacteria liquid with ultrahigh concentration for testing, and aims to ensure that the antibacterial rate of each test sample cannot reach 100 percent, so that the antibacterial performance of the test samples can be better distinguished.
The above description is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, several modifications and variations can be made without departing from the technical principle of the present invention, and these modifications and variations should also be regarded as the protection scope of the present invention.
Claims (8)
1. A preparation method of a medical dressing with antibacterial performance is characterized by comprising the following steps:
A. dissolving 4-6g of chitosan in 36-40mL of acetic acid solution, and uniformly stirring to obtain a chitosan solution X;
B. dissolving 8-10g of PVA in 32-40g of deionized water, and stirring at 80-90 ℃ for 30-60min to obtain a PVA solution Y;
C. dissolving lignosulfonate in deionized water, and uniformly stirring to obtain lignosulfonate solution Z;
D. dispersing the nano metal particles in 10g of deionized water to form nano metal particle dispersion liquid;
E. and D, respectively taking 10g of solution X, Y, Z, mixing with the nano metal dispersion liquid obtained in the step D, stirring for 5-8h, pouring into a mold, freezing for 8-10h at-18 ℃, then unfreezing at room temperature, and repeating for 5-8 times to obtain the hydrogel medical dressing.
2. A method of making according to claim 1, wherein: the volume concentration of the acetic acid solution is 2%.
3. A method of making according to claim 1, wherein: the concentration of the lignosulfonate solution was 30 wt%.
4. A method of making according to claim 1, wherein: the nano metal particles are silver or zinc.
5. A method of making according to claim 1, wherein: the nano metal particles are silver and zinc.
6. A method of preparing as defined in claim 4, wherein: the dosage of the nano metal particles is 0.29g-0.62 g.
7. A method of preparing as defined in claim 5, wherein: the mass of silver was 0.33g and the mass of zinc was 0.29 g.
8. A medical dressing with antibacterial properties, which is characterized in that: the medical dressing is prepared by any one of the methods of claims 1-7.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115054744A (en) * | 2022-05-19 | 2022-09-16 | 北京化工大学 | Antibacterial and anti-inflammatory degradable anti-adhesion material and preparation method and application thereof |
| CN115364274A (en) * | 2022-07-14 | 2022-11-22 | 贵州中医药大学 | Preparation and application of blood ginseng ethanol extract hydrogel |
| CN117815438A (en) * | 2023-12-27 | 2024-04-05 | 中南大学湘雅医院 | Multifunctional hydrogel and preparation method and application thereof |
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| CN102489716A (en) * | 2011-12-15 | 2012-06-13 | 湖南科技大学 | Preparation method for lignosulfonate nano-silver colloid |
| CN110755678A (en) * | 2019-11-13 | 2020-02-07 | 中国矿业大学 | 3D printing antibacterial hydrogel wound dressing based on green in-situ reduction |
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2021
- 2021-08-30 CN CN202111004517.4A patent/CN113679881A/en active Pending
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| CN102489716A (en) * | 2011-12-15 | 2012-06-13 | 湖南科技大学 | Preparation method for lignosulfonate nano-silver colloid |
| CN110755678A (en) * | 2019-11-13 | 2020-02-07 | 中国矿业大学 | 3D printing antibacterial hydrogel wound dressing based on green in-situ reduction |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115054744A (en) * | 2022-05-19 | 2022-09-16 | 北京化工大学 | Antibacterial and anti-inflammatory degradable anti-adhesion material and preparation method and application thereof |
| CN115364274A (en) * | 2022-07-14 | 2022-11-22 | 贵州中医药大学 | Preparation and application of blood ginseng ethanol extract hydrogel |
| CN117815438A (en) * | 2023-12-27 | 2024-04-05 | 中南大学湘雅医院 | Multifunctional hydrogel and preparation method and application thereof |
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