CN113679504B - Animal in-situ medicine sucking device - Google Patents
Animal in-situ medicine sucking device Download PDFInfo
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- CN113679504B CN113679504B CN202110684705.XA CN202110684705A CN113679504B CN 113679504 B CN113679504 B CN 113679504B CN 202110684705 A CN202110684705 A CN 202110684705A CN 113679504 B CN113679504 B CN 113679504B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/70—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in livestock or poultry
Abstract
The invention discloses animal in-situ drug sucking equipment, which comprises an operation room, a drug storage box, a first sensing device, a sensor and a controller, wherein the operation room is used for accommodating animals; the first sensing device comprises a first funnel and a second funnel, and the second funnel is sleeved in the first funnel and is hermetically arranged in the mounting hole; the medicine storage box comprises a valve which is in communication connection with the controller; the sensor is in communication connection with the controller and comprises an induction end and a transmitting end, wherein infrared rays are arranged between the induction end and the transmitting end; when the nose of the animal stretches into the horn mouth of the second funnel, the transmission path of the infrared rays is blocked, and the controller controls the valve to be opened at the moment; when the nose of the animal leaves the bell mouth of the second funnel, the controller controls the valve to be closed; the horn mouth of the first funnel is provided with negative pressure. The animal in-situ drug sucking device provided by the invention avoids the whole body of the animal from leaking in an atomized drug environment, reduces the damage of the atomized drug to the animal body, and improves the accuracy of the animal drug addiction experiment result.
Description
Technical Field
The invention relates to the technical field of animal addiction behavioural, in particular to animal in-situ drug sucking equipment.
Background
The self-administration experiment is a common method for behavioral and pharmacology research, is widely applied to the field of medicine addiction behavioural research, and utilizes the positive strengthening effect (the effect capable of generating special psychological experience and mental feeling) of certain medicines to control animals to make specified actions according to set experimental steps and give certain excitation to the animals (usually rats, mice, monkeys and the like), so that the animals establish the connection between behaviors and rewards, and further simulate the situation of human medicine addiction.
Currently, a common method of intake of most addictive substances is oral-nasal inhalation (including smoke inhalation, nasal inhalation, oral-nasal inhalation, etc.), and drugs inhaled from the oral-nasal inhalation are generally atomized and then enter the artery through the respiratory tract for circulation. In the prior art, experiments on aerosol administration have the following problems that, for example, the whole body of an animal is exposed to an environment of an atomized medicine, the atomized medicine not only damages the skin, eyes and ears of the animal, but also reduces the accuracy of the experimental result of the addiction of the animal to medicines.
Disclosure of Invention
Therefore, the invention aims to provide the animal in-situ drug sucking device, so as to avoid the whole body of an animal from leaking in an atomized drug environment, reduce the damage of atomized drug to the animal body and improve the accuracy of the animal drug addiction experiment result.
Based on the above object, the present invention provides an animal in-situ drug inhalation device, comprising a transparent operation room, a drug storage box containing atomized drugs, a first sensing device, a sensor and a controller, wherein: the operation chamber is used for accommodating animals and comprises a mounting surface, and mounting holes are formed in the mounting surface; the first induction device comprises a first funnel and a second funnel, wherein the bell mouth of the first funnel and the bell mouth of the second funnel are arranged on the same side, the second funnel is sleeved and installed in the first funnel, and the bell mouth of the first funnel faces the inside of the operation chamber and is installed in the installation hole in a sealing way; the medicine storage box is communicated with the internal channel of the second funnel and is used for providing atomized medicine for the animals, and comprises a valve which is in communication connection with the controller; the sensor is in communication connection with the controller, the sensor comprises an induction end and a transmitting end, the induction end and the transmitting end are respectively arranged at two ends which are oppositely arranged on the bell mouth of the second funnel, and infrared rays are arranged between the transmitting end and the induction end; when the nose of the animal extends into the flare of the second funnel, the nose of the animal blocks the transmission path of the infrared rays, and the controller controls the valve to open to provide the atomized medicine to the animal; when the nose of the animal exits the flare of the second funnel, the controller controls the valve to close to stop providing the aerosolized medicament; the horn mouth of the first funnel is provided with negative pressure for discharging atomized medicine remained in the operation chamber out of the operation chamber.
Optionally, the interval time between two adjacent times of opening the valve is set to be t, the interval between two adjacent times of extending the nose of the animal into the bell mouth of the second funnel is set to be t1, when t1 is smaller than or equal to t, the valve is closed, and when t1 is larger than t, the valve is opened.
Optionally, the medicine storage box comprises a pressurization air pump, the pressurization air pump is in communication connection with the controller, and when the valve is opened, the pressurization air pump conveys the atomized medicine to the second funnel.
Optionally, the animal in-situ medicine sucking device further comprises an exhaust gas adsorption box, a gas recovery pump, a recovery catheter and a communication catheter, wherein the gas recovery pump is in communication connection with the controller, one end of the recovery catheter is in sealing communication with the tail of the first funnel, the other end of the recovery catheter is in sealing communication with the exhaust gas adsorption box, and the exhaust gas adsorption box is in sealing communication with the gas recovery pump through the communication catheter.
Optionally, the first sensing device further comprises at least one supporting frame, and the supporting frame is installed between the outer side wall of the second funnel and the inner side wall of the first funnel.
Optionally, the animal in-situ medicine sucking device further includes a second sensing device, the structure of the second sensing device is identical to that of the first sensing device, the number of the mounting holes is two, the first sensing device and the second sensing device are respectively and hermetically mounted in the two mounting holes in one-to-one correspondence, and the second sensing device is communicated with the gas recovery pump, so that the second sensing device generates negative pressure at the bell mouth of the corresponding first funnel.
Optionally, the animal in-situ drug sucking device further comprises an atomized drug generating box and a smoke concentration sensor, wherein the smoke concentration sensor is installed in the drug storage box and is communicated with the controller; the atomized medicine produces the case with the medicine storage case is linked together, be provided with the electron smog spinning disk atomiser that is used for atomizing medicine on the atomized medicine produces the case, electron smog spinning disk atomiser with the controller is linked together, when smog concentration sensor detects in the medicine storage case the concentration of atomized medicine is less than first threshold value, the controller control the electron smog spinning disk atomiser is opened in order to produce atomized medicine.
Optionally, the animal in-situ medicine sucking device further comprises an air pressure sensor and a pressure release valve, the air pressure sensor is installed in the medicine storage box, the medicine storage box further comprises a connecting surface, a pressure release hole is formed in the connecting surface, the pressure release valve is installed on the pressure release hole in a sealing mode, the pressure release valve is connected with the controller in a communication mode, and when the air pressure sensor detects that the pressure in the medicine storage box exceeds a second threshold value, the controller controls the pressure release valve to be opened, so that the pressure in the medicine storage box is reduced to be smaller than or equal to the second threshold value.
Optionally, the animal in-situ medicine sucking device further comprises a sound generator, a first prompting lamp, a second prompting lamp and a cage lamp, wherein the sound generator, the first prompting lamp, the second prompting lamp and the cage lamp are all installed in the operation room, the first prompting lamp is installed on one side of the first induction device, the second prompting lamp is installed on one side of the second induction device, and the sound generator, the first prompting lamp, the second prompting lamp and the cage lamp are all electrically connected with the controller.
Optionally, the animal in-situ medicine sucking device further comprises a sound insulation box, the sound insulation box is sleeved and installed outside the operation room, the first sensing device and the second sensing device, and an environmental noise fan is installed on the sound insulation box.
Optionally, the operation room still includes a plurality of conductive metal poles, conductive metal pole with the controller electricity is connected, and a plurality of conductive metal pole tiling is in the top of the bottom of operation room, and with leave the clearance between the bottom of operation room, be provided with demountable installation's collection box in the clearance, be used for collecting animal's excrement and urine.
Optionally, at least one of the first sensing device and the second sensing device is integrally formed.
The invention provides animal in-situ medicine sucking equipment, which comprises a transparent operation room, a medicine storage box containing atomized medicine, a first sensing device, a sensor and a controller, wherein the first sensing device is hermetically arranged on a mounting surface in the operation room, the medicine storage box is communicated with an internal channel of a second funnel, an animal is positioned in the operation room, when the nose of the animal stretches into a horn mouth of the second funnel, the nose of the animal blocks a transmission path of infrared rays, and at the moment, the controller controls a valve to be opened so as to provide atomized medicine for the animal; when the nose of animal leaves the horn mouth of second funnel, the controller control valve is closed to stop providing the atomized medicine, above-mentioned experimental process, the horn mouth department of first funnel is provided with the negative pressure all the time for in time discharge the operation room with the atomized medicine of remaining in the operation room, thereby avoided the animal at the in-process of experiment, whole body is violently leaked under the atomized medicine environment, reduced the harm of atomized medicine to animal health, and improved the accuracy of animal to the experimental result of medicine addiction.
Drawings
The objects and advantages of the present invention will be better understood by describing in detail preferred embodiments thereof with reference to the accompanying drawings in which:
FIG. 1 is a schematic diagram of an in situ animal drug delivery device according to an embodiment of the present invention;
FIG. 2 is a first view of a first sensing device or a second sensing device of an in situ animal drug delivery device according to an embodiment of the present invention;
FIG. 3 is a second view of the first sensing device or the second sensing device of the animal in situ blotting apparatus according to an embodiment of the invention;
fig. 4 is a schematic structural view of an animal in-situ drug sucking device according to another embodiment of the present invention.
Reference numerals illustrate:
1: an operation chamber; 2: a medicine storage box; 3: a first sensing device; 4: a sensor; 5: a controller; 6: a pressurized air pump; 7: an exhaust gas adsorption box; 8: a gas recovery pump; 9: a recovery conduit; 10: a communication conduit; 11: a mounting surface; 12: a second sensing device; 13: an atomized medicine generation box; 14: a smoke concentration sensor; 15: an air pressure sensor; 16: a pressure release valve; 17: a sound generator; 18: a first indicator light; 19: a second indicator light; 20: cage lamp; 21: a valve; 22: a sound insulation box; 23: a conductive metal rod; 24: an ambient noise fan; 25: an automatic smoking machine; 26: an electronic cigarette atomizer; 31: a first funnel; 32: a second funnel; 33: a flare of the first funnel; 34: a flare of the second funnel; 35: a support frame; 36: the tail part of the first funnel; 37: the tail part of the second funnel; 51: a transmitting end; 52: an induction end; 53: a computer; 54: signal collection and processing software; 55: and a wireless transmission module.
Detailed Description
The present invention will be described in detail with reference to examples. Wherein like parts are designated by like reference numerals. It should be noted that the words "front", "rear", "left", "right", "upper" and "lower" used in the following description refer to directions in the drawings, and the words "inner" and "outer" refer to directions toward or away from, respectively, the geometric center of a particular component.
As shown in fig. 1 to 4, the in-situ animal drug sucking device provided by the invention comprises a transparent operation room 1, a drug storage box 2 containing atomized drugs, a first sensing device 3, a sensor 4 and a controller 5, wherein: the operation room 1 is used for accommodating animals, the operation room 1 comprises a mounting surface 11, and mounting holes are formed in the mounting surface 11; the first induction device 3 comprises a first funnel 31 and a second funnel 32, wherein a flare opening 33 of the first funnel and a flare opening 34 of the second funnel are arranged on the same side, the second funnel 32 is sleeved in the first funnel 31, and the flare opening 33 of the first funnel faces the inside of the operation chamber 1 and is hermetically arranged in the mounting hole; the medicine storage box 2 is communicated with the internal channel of the second funnel 32 and is used for providing atomized medicine for animals, the medicine storage box 2 comprises a valve 21, and the valve 21 is in communication connection with the controller 5; the sensor 4 is in communication connection with the controller 5, the sensor 4 comprises an induction end and a transmitting end, the induction end and the transmitting end are respectively arranged at two opposite ends of the bell mouth 34 of the second funnel, and infrared rays are arranged between the transmitting end and the induction end; when the nose of the animal is extended into the bell mouth 34 of the second hopper, the nose of the animal blocks the propagation path of the infrared rays, and at this time the controller 5 controls the valve 21 to be opened to supply atomized medicine to the animal; when the nose of the animal leaves the flare 34 of the second funnel, the controller 5 controls the valve 21 to close to stop providing the nebulised drug; a negative pressure is provided at the flare 33 of the first funnel for discharging atomized medicine remaining in the operation chamber 1 out of the operation chamber 1.
It should be noted that: the animal can be a mouse conforming to experimental conditions; the operation room 1 is provided with a door which can be opened and closed manually, so that animals can be conveniently put into the operation room 1 or taken out from the operation room 1, and the operation room 1 is made of plastic; the medicine storage box 2 is arranged in a sealing way, and the valve 21 is communicated with the medicine storage box 2 in a sealing way; the bell mouth 33 of the first funnel and the bell mouth 34 of the second funnel are respectively communicated with the operation chamber 1 in a sealing way through mounting holes, and the first induction device 3 is detachably mounted on the mounting surface 11 in a sealing way, so that the first induction device 3 can be replaced conveniently; the transmitting end transmits infrared rays to the sensing end at any time; the medicine storage box 2 can be communicated with the tail 37 of the second funnel; the controller 5 may include a computer 53, a signal collecting and processing software 54 and a wireless transmission module 55, where the computer 53, the signal collecting and processing software 54 and the wireless transmission module 55 display and record the nasal touch behavior of the animal in the experiment and the working conditions of the elements in real time, and establish an animal self-administration behavior model through the animal touching and self-inhalation behavior of atomized medicine; the inside diameter of the flare 34 of the second funnel is adapted to the size of the animal's nose so that the animal's nose can extend into the flare 34 of the second funnel; preferably, the flare 33 of the first funnel is completely covered outside the flare 34 of the second funnel to instantaneously discharge atomized medicine, which escapes near the flare 34 of the second funnel and is not inhaled into the body by the animal, out of the operation chamber 1 in time.
The invention provides animal in-situ medicine sucking equipment, which comprises a transparent operation room 1, a medicine storage box 2 containing atomized medicine, a first sensing device 3, a sensor 4 and a controller 5, wherein the first sensing device 3 is hermetically arranged on a mounting surface 11 in the operation room 1, the medicine storage box 2 is communicated with an internal channel of a second funnel 32, an animal is positioned in the operation room 1, when the nose of the animal stretches into a horn mouth 34 of the second funnel, the nose of the animal blocks a transmission path of infrared rays, and at the moment, the controller 5 controls a valve 21 to be opened so as to provide the atomized medicine for the animal; when the nose of the animal leaves the bell mouth 34 of the second funnel, the controller 5 controls the valve 21 to be closed so as to stop providing atomized medicine, and in the experimental process, the negative pressure is always arranged at the bell mouth 33 of the first funnel and used for timely discharging the atomized medicine remained in the operation room 1 out of the operation room 1, so that the situation that the whole body of the animal is leaked under the environment of the atomized medicine in the experimental process is avoided, the damage of the atomized medicine to the animal body is reduced, and the accuracy of the experimental result of the addiction of the animal to the medicine is improved.
In an embodiment of the present invention, the interval between the opening of the two adjacent valves 21 is set to t, the interval between the two adjacent animal noses extending into the bell mouth 34 of the second funnel is set to t1, when t1 is less than or equal to t, the valve 21 is closed, when t1 is greater than t, the valve 21 is opened, thereby avoiding the animal from excessively and continuously inhaling atomized medicine in a short time to cause body injury, specifically, t can be set to 30 seconds, and when the animal noses extend into the bell mouth 34 of the second funnel twice or more in 30 seconds, although the animal noses block the transmission path of the infrared rays twice or more, the controller 5 still controls the valve 21 to be closed, i.e. the medicine storage box 2 still does not provide atomized medicine for the animal, thereby avoiding the animal from excessively and continuously inhaling atomized medicine in a short time to cause body injury, and improving the use safety of the animal in-situ medicine sucking device.
As shown in fig. 1, the medicine-storage tank 2 includes a pressurized air pump 6, the pressurized air pump 6 being in communication with the controller 5, and when the valve 21 is opened, the pressurized air pump 6 delivers the atomized medicine to the second hopper 32. In this embodiment, specifically, the controller 5 can control the opening or closing of the pressurizing air pump 6 as required, and the medicine storage box 2 provides atomized medicine to the animal through the pressurizing air pump 6, so that the operation convenience of the animal in-situ medicine sucking device is improved.
As shown in fig. 1, the animal in-situ medicine sucking device further comprises an exhaust gas adsorption box 7, a gas recovery pump 8, a recovery conduit 9 and a communication conduit 10, wherein the gas recovery pump 8 is in communication connection with the controller 5, one end of the recovery conduit 9 is in sealing communication with the tail 36 of the first funnel, the other end of the recovery conduit 9 is in sealing communication with the exhaust gas adsorption box 7, and the exhaust gas adsorption box 7 is in sealing communication with the gas recovery pump 8 through the communication conduit 10. It should be noted that: the material that can adsorb the atomized medicine is provided with in the waste gas adsorption box 7, can collect the animal does not inhale the internal atomized medicine in waste gas adsorption box 7, and the gas is retrieved pump 8 and is carried out the further collection with the atomized medicine that waste gas adsorption box 7 did not collect, has avoided atomized medicine to enter into in the air, polluted environment. In this embodiment, the controller 5 controls the gas recovery pump 8 to continuously provide negative pressure near the bell mouth 33 of the first funnel, that is, the gas recovery pump 8 can timely and instantaneously discharge atomized medicine, which is dissipated in the operation chamber 1 and is not inhaled by the animal, out of the operation chamber 1, thereby avoiding the whole body of the animal from leaking in the atomized medicine environment, reducing the damage of the atomized medicine to the animal body, and improving the accuracy of the experimental result of the addiction of the animal to the medicine.
As shown in fig. 2 and 3, the first sensing device 3 further comprises at least one supporting frame 35, and the supporting frame 35 is mounted between the outer side wall of the second funnel 32 and the inner side wall of the first funnel 31. In this embodiment, the supporting frame 35 increases the supporting strength between the first funnel 31 and the second funnel 32, and improves the structural strength of the first sensing device 3.
As shown in fig. 1, the animal in-situ medicine sucking device further comprises a second sensing device 12, the structure of the second sensing device 12 is identical to that of the first sensing device 3, two mounting holes are formed, the first sensing device 3 and the second sensing device 12 are respectively and hermetically mounted in the two mounting holes in a one-to-one correspondence manner, and the second sensing device 12 is communicated with the gas recovery pump 8 so that the second sensing device 12 generates negative pressure at a horn mouth 33 of a corresponding first funnel. It should be noted that the second sensing device 12 is not in communication with the medicine storage tank 2, i.e., no atomized medicine is contained in the second sensing device 12. In this embodiment, the second sensing device 12 is also provided with the same negative pressure as the first sensing device 3 at the bell mouth 33 of the first funnel, so that the animal experiences the same when being located at the first sensing device 3 or the second sensing device 12, and if the animal still is willing to acquire atomized medicine through the first sensing device 3, the addiction of the animal to the atomized medicine is proved, and the accuracy of the experimental result of the addiction of the animal to the medicine in the animal in-situ medicine sucking device is improved.
As shown in fig. 1, the animal in-situ medicine sucking device further comprises an atomized medicine generating box 13 and a smoke concentration sensor 14, wherein the smoke concentration sensor 14 is arranged in the medicine storage box 2, and the smoke concentration sensor 14 is communicated with the controller 5; the atomized medicine producing box 13 is communicated with the medicine storage box 2, an electronic cigarette atomizer 26 for atomizing medicine is arranged on the atomized medicine producing box 13, the electronic cigarette atomizer 26 is communicated with the controller 5, and when the smoke concentration sensor 14 detects that the concentration of atomized medicine in the medicine storage box 2 is lower than a first threshold value, the controller 5 controls the electronic cigarette atomizer 26 to be opened so as to produce atomized medicine. The atomized medicine generating box 13 can be replaced by an automatic smoking machine 25, and the automatic smoking machine 25 can continuously simulate the human smoking of cigarettes one by one to generate cigarette smoke, so as to simulate the actual animal cigarette smoke inhalation. In this embodiment, the smoke concentration sensor 14 can ensure that the medicine storage box 2 provides atomized medicine more stably, so that inaccurate experimental results caused by untimely supply of atomized medicine in the medicine storage box 2 are avoided, and accuracy of experimental results of addiction to medicines of animals in the animal in-situ medicine sucking device is improved.
As shown in fig. 1, the animal in-situ medicine sucking device further comprises an air pressure sensor 15 and a pressure release valve 16, wherein the air pressure sensor 15 is installed in the medicine storage box 2, the medicine storage box 2 further comprises a connecting surface, a pressure release hole is formed in the connecting surface, the pressure release valve 16 is installed on the pressure release hole in a sealing mode, the pressure release valve 16 is in communication connection with the controller 5, and when the air pressure sensor 15 detects that the pressure in the medicine storage box 2 exceeds a second threshold value, the controller 5 controls the pressure release valve 16 to be opened so as to enable the pressure in the medicine storage box 2 to be reduced to be smaller than or equal to the second threshold value. According to the embodiment, the atomized medicine with stable pressure in the medicine storage box 2 is ensured, so that the atomized medicine with stable pressure is provided for experiments, and the accuracy of the experimental results of the addiction of animals to medicines in the animal in-situ medicine sucking equipment is improved.
As shown in fig. 1, the animal in-situ medicine sucking device further includes a sound generator 17, a first indicator light 18, a second indicator light 19 and a cage light 20, where the sound generator 17, the first indicator light 18, the second indicator light 19 and the cage light 20 are all installed in the operation room 1, the first indicator light 18 is installed on one side of the first sensing device 3, the second indicator light 19 is installed on one side of the second sensing device 12, and the sound generator 17, the first indicator light 18, the second indicator light 19 and the cage light 20 are all electrically connected with the controller 5. It should be noted that: specifically, when the animal does not enter the operation room 1, the cage lamp 20 is set to be unlit, and when the animal enters the operation room 1, the cage lamp 20 is lighted, so that illumination is provided for animal activities; when an animal enters the operation room 1, the controller 5 controls the sound generator 17 to sound so as to remind the animal of entering the operation room 1; when the animal is located on one side of the first sensing device 3, the first indicator light 18 is on, and when the animal is located on one side of the second sensing device 12, the second indicator light 19 is on, so that the position of the animal in the operation room 1 can be more intuitively known, and in this embodiment, the convenience of use of the animal in-situ medicine sucking device is improved.
As shown in fig. 4, the animal in-situ medicine sucking device further comprises a sound insulation box 22, the sound insulation box 22 is sleeved outside the operation room 1, the first sensing device 3 and the second sensing device 12, and an environmental noise fan 24 is installed on the sound insulation box 22. It should be noted that: the sound insulation board is made of wood, and the inner wall of the sound insulation box 22 is covered with rough EVA foam, so that external noise is isolated and absorbed, and a dark environment is caused while sound insulation is carried out; ambient noise fan 24 is capable of providing slight ambient white noise and ventilation. In this embodiment, the sound insulation box 22 isolates and adsorbs external noise, so as to avoid the influence of external noise on animals, and improve the accuracy of the experimental result of the animal addiction to medicines in the animal in-situ drug inhalation device.
As shown in fig. 1, the operation room 1 further includes a plurality of conductive metal rods 23, the conductive metal rods 23 are electrically connected with the controller 5, the plurality of conductive metal rods 23 are tiled above the bottom of the operation room 1, a gap is reserved between the conductive metal rods and the bottom of the operation room 1, and a collection box which is detachably installed is arranged in the gap and used for collecting the faeces and urine of animals, so that the convenience of use of the animal in-situ drug inhalation device is improved. In this embodiment, the controller 5 energizes the conductive metal rod 23, so as to apply current to the sole of the animal, at this time, observe whether the drug-seeking behavior of the animal is inhibited, and further determine the addiction of the animal to the drug, that is, whether the animal expects to be electrified or wants to stretch the nose into the bell mouth 34 of the second funnel, so as to obtain atomized drug.
In this embodiment, at least one of the first sensing device 3 and the second sensing device 12 is integrally formed, and is integrally formed, so that the number of open molds is reduced, the manufacturing process is simplified, mass production is facilitated, the materials of the first sensing device 3 and the second sensing device 12 can be glass, and the drawing process is integrally formed.
In another embodiment of the present invention, the controller 5 may be connected to and control a plurality of the animal in-situ drug inhalation devices at the same time, so as to realize batch training, save the time of the experimenter, and reduce the difference between groups caused by different training time.
The experimental process provided by the invention is as follows: firstly, the animals are gently placed in a laboratory 1, the door of the laboratory 1 is closed, a door lock catch of a sound insulation box 22 is buckled, at the moment, a cage lamp 20 is on, and a sound generator 17 generates a beeping sound for 2 seconds; then, when the nose of the animal is inserted into the bell mouth 34 of the second funnel in the first sensing device 3, the cage lamp 20 is turned off, the first indicator lamp 18 is turned on for 5 seconds to provide basic lighting and azimuth information, and simultaneously the pressurized air pump 6 is operated, and the valve 21 is turned on for 3 seconds to continuously supply atomized medicine. The period of system refractory period is 30 seconds after the spraying, namely 30 seconds after the first atomization administration, no matter how many times the nose of the animal stretches into the bell mouth 34 of the second funnel, the valve 21 is closed, namely no atomization medicine is provided for the animal; after the 30 second refractory period, when the nose of the animal stretches into the bell mouth 34 of the second funnel on the first sensing device 3 again, the controller 5 controls the valve 21 to be opened, namely atomized medicine is provided for the animal; when the nose of the animal leaves the bell mouth 34 of the second funnel in the first sensing means 3, the valve 21 is closed, stopping the supply of the nebulised drug, and the above process is cycled in sequence; finally, the experiment was ended when the number of administrations of the aerosolized drug exceeded 60 times, or the experimental time exceeded 90 minutes.
It should be noted that: besides the study of in-situ drug addiction of animals, the system can also be used for the study of withdrawal after addiction and relapse after withdrawal, and only the program is adjusted according to the experimental scheme. Furthermore, the dosing patterns of fixed intervals, fixed rates, progressive rates, etc. can be programmed (the training patterns can be modified to adjust different training patterns according to the program) to complete further animal drug addiction studies.
The invention provides animal in-situ medicine sucking equipment, which comprises a transparent operation room 1, a medicine storage box 2 containing atomized medicine, a first sensing device 3, a sensor 4 and a controller 5, wherein the first sensing device 3 is hermetically arranged on a mounting surface 11 in the operation room 1, the medicine storage box 2 is communicated with an internal channel of a second funnel 32, an animal is positioned in the operation room 1, when the nose of the animal stretches into a horn mouth 34 of the second funnel, the nose of the animal blocks a transmission path of infrared rays, and at the moment, the controller 5 controls a valve 21 to be opened so as to provide the atomized medicine for the animal; when the nose of the animal leaves the bell mouth 34 of the second funnel, the controller 5 controls the valve 21 to be closed so as to stop providing atomized medicine, and in the experimental process, the negative pressure is always arranged at the bell mouth 33 of the first funnel and used for timely discharging the atomized medicine remained in the operation room 1 out of the operation room 1, so that the situation that the whole body of the animal is leaked under the environment of the atomized medicine in the experimental process is avoided, the damage of the atomized medicine to the animal body is reduced, and the accuracy of the experimental result of the addiction of the animal to the medicine is improved.
Finally, it should be noted that: the above embodiments are only for illustrating the technical solution of the present invention, and are not limiting; although the invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit of the invention.
Claims (10)
1. An animal normal position medicine equipment of inhaling, its characterized in that includes transparent control room, contains the medicine storage box of atomizing medicine, first induction system, sensor and controller, wherein:
the operation chamber is used for accommodating animals and comprises a mounting surface, and mounting holes are formed in the mounting surface;
the first induction device comprises a first funnel and a second funnel, wherein the bell mouth of the first funnel and the bell mouth of the second funnel are arranged on the same side, the second funnel is sleeved and installed in the first funnel, and the bell mouth of the first funnel faces the inside of the operation chamber and is installed in the installation hole in a sealing way;
the medicine storage box is communicated with the internal channel of the second funnel and is used for providing atomized medicine for the animals, and comprises a valve which is in communication connection with the controller; the sensor is in communication connection with the controller, the sensor comprises an induction end and a transmitting end, the induction end and the transmitting end are respectively arranged at two ends which are oppositely arranged on the bell mouth of the second funnel, and infrared rays are arranged between the transmitting end and the induction end;
when the nose of the animal extends into the flare of the second funnel, the nose of the animal blocks the transmission path of the infrared rays, and the controller controls the valve to open to provide the atomized medicine to the animal; when the nose of the animal exits the flare of the second funnel, the controller controls the valve to close to stop providing the aerosolized medicament;
a negative pressure is arranged at the horn mouth of the first funnel and used for discharging atomized medicine remained in the operation chamber out of the operation chamber;
the interval time between two adjacent times of opening the valve is set as t, and the interval time between two adjacent times of stretching the nose of the animal into the bell mouth of the second funnel is set as t 1 When t 1 When t is less than or equal to, the valve is closed, when t 1 When the valve is larger than t, the valve is opened;
the animal in-situ medicine sucking equipment further comprises a second induction device, the structure of the second induction device is identical to that of the first induction device, the number of the installation holes is two, the first induction device and the second induction device are respectively and hermetically installed in the two installation holes in one-to-one correspondence, and the second induction device is communicated with the gas recovery pump so that the second induction device generates negative pressure at the horn mouth of the corresponding first funnel.
2. The animal in situ drug delivery apparatus of claim 1, wherein the drug storage tank includes a pressurized air pump in communication with the controller, the pressurized air pump delivering the aerosolized drug to the second hopper when the valve is opened.
3. The animal in situ drug delivery apparatus of claim 2, further comprising an exhaust gas adsorption cartridge, a gas recovery pump, a recovery conduit, and a communication conduit, wherein the gas recovery pump is in communication with the controller, one end of the recovery conduit is in sealed communication with the tail of the first funnel, the other end of the recovery conduit is in sealed communication with the exhaust gas adsorption cartridge, and the exhaust gas adsorption cartridge is in sealed communication with the gas recovery pump via the communication conduit.
4. The animal in situ drug delivery apparatus of claim 3, wherein the first sensing device further comprises at least one support bracket mounted between an outer sidewall of the second funnel and an inner sidewall of the first funnel.
5. The animal in situ drug delivery apparatus of claim 4, further comprising an aerosolized drug generating bin and a smoke concentration sensor mounted within the drug storage bin, the smoke concentration sensor in communication with the controller; the atomized medicine produces the case with the medicine storage case is linked together, be provided with the electron smog spinning disk atomiser that is used for atomizing medicine on the atomized medicine produces the case, electron smog spinning disk atomiser with the controller is linked together, when smog concentration sensor detects in the medicine storage case the concentration of atomized medicine is less than first threshold value, the controller control the electron smog spinning disk atomiser is opened in order to produce atomized medicine.
6. The animal in situ drug delivery apparatus of claim 5, further comprising a pneumatic sensor and a pressure relief valve, wherein the pneumatic sensor is mounted in the drug storage tank, the drug storage tank further comprises a connection surface, a pressure relief hole is formed in the connection surface, the pressure relief valve is mounted on the pressure relief hole in a sealing manner, the pressure relief valve is in communication connection with the controller, and when the pneumatic sensor detects that the pressure in the drug storage tank exceeds a second threshold value, the controller controls the pressure relief valve to open so that the pressure in the drug storage tank is reduced to be less than or equal to the second threshold value.
7. The animal in situ drug delivery apparatus of claim 6, further comprising a sound generator, a first indicator light, a second indicator light, and a cage light, wherein the sound generator, the first indicator light, the second indicator light, and the cage light are all mounted in the operating chamber, and wherein the first indicator light is mounted on one side of the first sensing device, the second indicator light is mounted on one side of the second sensing device, and wherein the sound generator, the first indicator light, the second indicator light, and the cage light are all electrically connected to the controller.
8. The animal in situ drug delivery apparatus of claim 7, further comprising a sound-proof housing, wherein the sound-proof housing is mounted outside the operating room, the first sensing device, and the second sensing device, and wherein an ambient noise fan is mounted on the sound-proof housing.
9. The animal in-situ drug delivery device of claim 8, wherein the operating chamber further comprises a plurality of conductive metal rods electrically connected to the controller, wherein the plurality of conductive metal rods are tiled above the bottom of the operating chamber and leave a gap with the bottom of the operating chamber, and a detachably mounted collection box is disposed in the gap for collecting feces and urine of the animal.
10. The animal in situ drug delivery apparatus of any one of claims 1-9, wherein at least one of the first sensing device and the second sensing device is integrally formed.
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