CN113677698B - 用于癌症诊断和治疗的新的psma特异性结合蛋白 - Google Patents

用于癌症诊断和治疗的新的psma特异性结合蛋白 Download PDF

Info

Publication number
CN113677698B
CN113677698B CN202080027745.0A CN202080027745A CN113677698B CN 113677698 B CN113677698 B CN 113677698B CN 202080027745 A CN202080027745 A CN 202080027745A CN 113677698 B CN113677698 B CN 113677698B
Authority
CN
China
Prior art keywords
ala
leu
psma
ile
thr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN202080027745.0A
Other languages
English (en)
Chinese (zh)
Other versions
CN113677698A (zh
Inventor
伊瓦·博塞-德内克
马尼亚·格洛泽-布罗伊尼格
弗洛里安·塞泰莱
埃里克·菲德勒
乌尔里希·豪普茨
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Navigo Proteins GmbH
Original Assignee
Scil Proteins GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scil Proteins GmbH filed Critical Scil Proteins GmbH
Publication of CN113677698A publication Critical patent/CN113677698A/zh
Application granted granted Critical
Publication of CN113677698B publication Critical patent/CN113677698B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN202080027745.0A 2019-04-10 2020-04-08 用于癌症诊断和治疗的新的psma特异性结合蛋白 Active CN113677698B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19168525.4 2019-04-10
EP19168525 2019-04-10
PCT/EP2020/060043 WO2020208083A1 (en) 2019-04-10 2020-04-08 Novel psma specific binding proteins for cancer diagnosis and treatment

Publications (2)

Publication Number Publication Date
CN113677698A CN113677698A (zh) 2021-11-19
CN113677698B true CN113677698B (zh) 2025-02-25

Family

ID=66286079

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080027745.0A Active CN113677698B (zh) 2019-04-10 2020-04-08 用于癌症诊断和治疗的新的psma特异性结合蛋白

Country Status (12)

Country Link
US (1) US12611441B2 (enExample)
EP (2) EP4108680B1 (enExample)
JP (1) JP7498971B2 (enExample)
KR (1) KR102934740B1 (enExample)
CN (1) CN113677698B (enExample)
AU (1) AU2020271959B2 (enExample)
BR (1) BR112021017863A2 (enExample)
CA (1) CA3136229A1 (enExample)
IL (1) IL286791A (enExample)
SG (1) SG11202110940YA (enExample)
WO (1) WO2020208083A1 (enExample)
ZA (1) ZA202108843B (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023285164A1 (en) * 2021-07-13 2023-01-19 Navigo Proteins Gmbh Affinity ligands for the purification and detection of ubiquitin muteins
CN114569744A (zh) * 2022-03-08 2022-06-03 安徽淮仁堂药业股份有限公司 一种锝前列腺标特异性膜抗原显像剂试剂盒及其制备方法和应用
CN116041435B (zh) * 2023-02-21 2023-07-07 浙江农林大学 一种具有2019新型冠状病毒主蛋白酶抑制活性的榛仁蛋白衍生肽及其应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103539851A (zh) * 2003-05-28 2014-01-29 塞尔蛋白质股份有限公司 基于泛素蛋白的人工结合蛋白的生产
CN107849116A (zh) * 2015-05-06 2018-03-27 詹森生物科技公司 前列腺特异性膜抗原结合iii型纤连蛋白结构域

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003035839A2 (en) * 2001-10-24 2003-05-01 Dgi Biotechnologies, Inc. Target specific screening andits use for identifying target binders
US7749968B2 (en) * 2002-08-05 2010-07-06 The Johns Hopkins University Peptides for targeting the prostate specific membrane antigen
BR112012014417B1 (pt) 2009-12-14 2021-11-09 Scil Proteins Gmbh Proteínas ubiquitinas modificadas tendo uma atividade de ligação específica para o extradomínio b de fibronectina
WO2012171541A1 (en) 2011-06-15 2012-12-20 Scil Proteins Gmbh Human fusion proteins comprising interferons and hetero-dimeric modified ubiquitin proteins
EP3253785B1 (en) * 2015-02-06 2019-04-10 Navigo Proteins Gmbh Novel egfr binding proteins
US20180030140A1 (en) 2015-02-06 2018-02-01 Navigo Proteins Gmbh Novel binding proteins comprising a ubiquitin mutein and antibodies or antibody fragments
CN107849147B (zh) * 2015-07-20 2021-09-17 纳维格蛋白质有限公司 基于二泛素突变蛋白的Her2结合蛋白
JP2018520675A (ja) * 2015-07-20 2018-08-02 ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツングＮａｖｉｇｏ Ｐｒｏｔｅｉｎｓ ＧｍｂＨ ジユビキチン変異タンパク質をベースとした新規結合タンパク質及びその生成方法
WO2017149002A1 (en) * 2016-03-03 2017-09-08 Navigo Proteins Gmbh Novel fusion proteins for capturing of cells
WO2023285164A1 (en) * 2021-07-13 2023-01-19 Navigo Proteins Gmbh Affinity ligands for the purification and detection of ubiquitin muteins

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103539851A (zh) * 2003-05-28 2014-01-29 塞尔蛋白质股份有限公司 基于泛素蛋白的人工结合蛋白的生产
CN107849116A (zh) * 2015-05-06 2018-03-27 詹森生物科技公司 前列腺特异性膜抗原结合iii型纤连蛋白结构域

Also Published As

Publication number Publication date
EP3953375C0 (en) 2023-06-07
AU2020271959A1 (en) 2021-09-16
EP4108680B1 (en) 2024-05-01
WO2020208083A1 (en) 2020-10-15
JP7498971B2 (ja) 2024-06-13
JP2022528053A (ja) 2022-06-08
ZA202108843B (en) 2023-07-26
BR112021017863A2 (pt) 2022-01-04
AU2020271959B2 (en) 2022-09-29
SG11202110940YA (en) 2021-10-28
EP3953375A1 (en) 2022-02-16
IL286791A (en) 2021-10-31
EP4108680A1 (en) 2022-12-28
CA3136229A1 (en) 2020-10-15
US12611441B2 (en) 2026-04-28
US20220168386A1 (en) 2022-06-02
EP3953375B1 (en) 2023-06-07
KR20210150535A (ko) 2021-12-10
EP3953375B9 (en) 2023-10-04
CN113677698A (zh) 2021-11-19
KR102934740B1 (ko) 2026-03-04
EP4108680C0 (en) 2024-05-01

Similar Documents

Publication Publication Date Title
CN107849147B (zh) 基于二泛素突变蛋白的Her2结合蛋白
JP7608538B2 (ja) 癌の診断および治療のための新規なｆｏｌｒ１特異的結合タンパク質
US12611441B2 (en) PSMA specific binding proteins for cancer diagnosis and treatment
JP2026031936A (ja) 線維芽細胞活性化タンパク質（ｆａｐ）のための特異的結合性分子
EP4326749A1 (en) Novel human programmed death ligand 1 (pd-l1) specific binding molecules
EP4161954B1 (en) Serum stable binding proteins for human her2 for theranostic applications
CN119487061A (zh) 具有半衰期延长结构域的融合蛋白
CN119866345A (zh) 对程序性死亡配体1（pd-l1）具有高结合亲和力的新的蛋白质

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant