CN113677673B - Trpc6的抑制剂 - Google Patents

Trpc6的抑制剂 Download PDF

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Publication number
CN113677673B
CN113677673B CN202080028064.6A CN202080028064A CN113677673B CN 113677673 B CN113677673 B CN 113677673B CN 202080028064 A CN202080028064 A CN 202080028064A CN 113677673 B CN113677673 B CN 113677673B
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China
Prior art keywords
trpc6
mmol
compounds
int
hplc
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CN202080028064.6A
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English (en)
Chinese (zh)
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CN113677673A (zh
Inventor
D·格特施灵
T·布伊索
N·海涅
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Boehringer Ingelheim International GmbH
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Boehringer Ingelheim International GmbH
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN202080028064.6A 2019-04-12 2020-04-07 Trpc6的抑制剂 Active CN113677673B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19168845 2019-04-12
EP19168845.6 2019-04-12
PCT/EP2020/059854 WO2020208002A1 (en) 2019-04-12 2020-04-07 Inhibitors of trpc6

Publications (2)

Publication Number Publication Date
CN113677673A CN113677673A (zh) 2021-11-19
CN113677673B true CN113677673B (zh) 2024-03-05

Family

ID=66175186

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080028064.6A Active CN113677673B (zh) 2019-04-12 2020-04-07 Trpc6的抑制剂

Country Status (5)

Country Link
US (1) US12156874B2 (https=)
EP (1) EP3959206A1 (https=)
JP (1) JP7585227B2 (https=)
CN (1) CN113677673B (https=)
WO (1) WO2020208002A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11485740B2 (en) * 2018-02-15 2022-11-01 Boehringer Ingelheim International Gmbh Inhibitors of TRPC6
WO2020208002A1 (en) 2019-04-12 2020-10-15 Boehringer Ingelheim International Gmbh Inhibitors of trpc6
EP4135696A1 (en) * 2020-04-16 2023-02-22 Boehringer Ingelheim International GmbH Inhibitors of trpc6 for treating respiratory conditions
AU2022366192A1 (en) * 2021-10-15 2024-02-29 Boehringer Ingelheim International Gmbh Trpc6 inhibitory compounds for treating sepsis

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1516691A (zh) * 2001-06-15 2004-07-28 ֮����ҩ��ʽ���� 苯基吡啶甲酰哌嗪衍生物
CN107253952A (zh) * 2017-08-01 2017-10-17 烟台大学 具有抗胃癌活性的trpc6抑制剂及其制备方法和用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3786160T3 (da) * 2017-10-27 2022-08-22 Boehringer Ingelheim Int Pyridinderivater og terapeutiske anvendelser deraf som trpc6-inhibitorer
US11370771B2 (en) 2018-02-16 2022-06-28 Boehringer Ingelheim International Gmbh Inhibitors of TRPC6
WO2019169168A1 (en) 2018-02-28 2019-09-06 Evelo Biosciences, Inc. Compositions and methods for treating cancer using agathobaculum
WO2020208002A1 (en) 2019-04-12 2020-10-15 Boehringer Ingelheim International Gmbh Inhibitors of trpc6

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1516691A (zh) * 2001-06-15 2004-07-28 ֮����ҩ��ʽ���� 苯基吡啶甲酰哌嗪衍生物
CN107253952A (zh) * 2017-08-01 2017-10-17 烟台大学 具有抗胃癌活性的trpc6抑制剂及其制备方法和用途

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Screening of TRPC Channel Activators Identifies Novel Neurotrophic Piperazine Compounds;Sawamura,S.等;《Molecular Pharmacology》;第89卷(第3期);348-363 *

Also Published As

Publication number Publication date
CN113677673A (zh) 2021-11-19
WO2020208002A1 (en) 2020-10-15
JP2022527618A (ja) 2022-06-02
US12156874B2 (en) 2024-12-03
EP3959206A1 (en) 2022-03-02
JP7585227B2 (ja) 2024-11-18
US20220152023A1 (en) 2022-05-19

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