CN113677673B - Trpc6的抑制剂 - Google Patents

Trpc6的抑制剂 Download PDF

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Publication number
CN113677673B
CN113677673B CN202080028064.6A CN202080028064A CN113677673B CN 113677673 B CN113677673 B CN 113677673B CN 202080028064 A CN202080028064 A CN 202080028064A CN 113677673 B CN113677673 B CN 113677673B
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CN
China
Prior art keywords
trpc6
mmol
compounds
int
hplc
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CN202080028064.6A
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English (en)
Chinese (zh)
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CN113677673A (zh
Inventor
D·格特施灵
T·布伊索
N·海涅
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Boehringer Ingelheim International GmbH
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Boehringer Ingelheim International GmbH
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Publication of CN113677673A publication Critical patent/CN113677673A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN202080028064.6A 2019-04-12 2020-04-07 Trpc6的抑制剂 Active CN113677673B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19168845 2019-04-12
EP19168845.6 2019-04-12
PCT/EP2020/059854 WO2020208002A1 (en) 2019-04-12 2020-04-07 Inhibitors of trpc6

Publications (2)

Publication Number Publication Date
CN113677673A CN113677673A (zh) 2021-11-19
CN113677673B true CN113677673B (zh) 2024-03-05

Family

ID=66175186

Family Applications (1)

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CN202080028064.6A Active CN113677673B (zh) 2019-04-12 2020-04-07 Trpc6的抑制剂

Country Status (5)

Country Link
US (1) US12156874B2 (enExample)
EP (1) EP3959206A1 (enExample)
JP (1) JP7585227B2 (enExample)
CN (1) CN113677673B (enExample)
WO (1) WO2020208002A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3752499B1 (en) * 2018-02-15 2024-03-27 Boehringer Ingelheim International GmbH Inhibitors of trpc6
CN113677673B (zh) 2019-04-12 2024-03-05 勃林格殷格翰国际有限公司 Trpc6的抑制剂
MX2022012923A (es) * 2020-04-16 2022-11-16 Boehringer Ingelheim Int Inhibidores de trpc6 para tratar afecciones respiratorias.
KR20240093600A (ko) * 2021-10-15 2024-06-24 베링거 인겔하임 인터내셔날 게엠베하 패혈증 치료를 위한 trpc6 억제 화합물

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1516691A (zh) * 2001-06-15 2004-07-28 ֮����ҩ��ʽ���� 苯基吡啶甲酰哌嗪衍生物
CN107253952A (zh) * 2017-08-01 2017-10-17 烟台大学 具有抗胃癌活性的trpc6抑制剂及其制备方法和用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200125758A (ko) * 2017-10-27 2020-11-04 베링거 인겔하임 인터내셔날 게엠베하 피리딘 카보닐 유도체 및 trpc6 억제제로서 이의 치료학적 용도
CN111868055B (zh) * 2018-02-16 2024-03-08 勃林格殷格翰国际有限公司 Trpc6的抑制剂
WO2019169168A1 (en) 2018-02-28 2019-09-06 Evelo Biosciences, Inc. Compositions and methods for treating cancer using agathobaculum
CN113677673B (zh) 2019-04-12 2024-03-05 勃林格殷格翰国际有限公司 Trpc6的抑制剂

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1516691A (zh) * 2001-06-15 2004-07-28 ֮����ҩ��ʽ���� 苯基吡啶甲酰哌嗪衍生物
CN107253952A (zh) * 2017-08-01 2017-10-17 烟台大学 具有抗胃癌活性的trpc6抑制剂及其制备方法和用途

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Screening of TRPC Channel Activators Identifies Novel Neurotrophic Piperazine Compounds;Sawamura,S.等;《Molecular Pharmacology》;第89卷(第3期);348-363 *

Also Published As

Publication number Publication date
US12156874B2 (en) 2024-12-03
US20220152023A1 (en) 2022-05-19
JP2022527618A (ja) 2022-06-02
EP3959206A1 (en) 2022-03-02
CN113677673A (zh) 2021-11-19
WO2020208002A1 (en) 2020-10-15
JP7585227B2 (ja) 2024-11-18

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