CN113671427A - Magnetic resonance elastography displacement acquisition method and system - Google Patents
Magnetic resonance elastography displacement acquisition method and system Download PDFInfo
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- CN113671427A CN113671427A CN202110977034.6A CN202110977034A CN113671427A CN 113671427 A CN113671427 A CN 113671427A CN 202110977034 A CN202110977034 A CN 202110977034A CN 113671427 A CN113671427 A CN 113671427A
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- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
- G01R33/32—Excitation or detection systems, e.g. using radio frequency signals
- G01R33/36—Electrical details, e.g. matching or coupling of the coil to the receiver
Abstract
The invention provides a displacement acquisition method and a system for magnetic resonance elastography, which relate to the technical field of magnetic resonance imaging, and the method comprises the following steps: step S1: setting an external driver, setting external trigger drive and frequency, applying shear fluctuation with certain frequency to a detection object, and generating the propagation of the shear fluctuation in the application object; step S2: and carrying out motion coding on the shearing fluctuation, and acquiring image information of displacement of the shearing fluctuation in the detection object along with time and space changes. The invention can solve the problem of collecting sampling points of different motion phases of periodic displacement in elastography, and better realizes the flexible recording and motion coding of the periodic displacement.
Description
Technical Field
The invention relates to the technical field of magnetic resonance imaging, in particular to a displacement acquisition method and system for magnetic resonance elastography.
Background
Magnetic Resonance Imaging (MRI) has become one of the most important clinical diagnostic tools due to its advantages such as excellent soft tissue contrast, multiple functional Imaging means and no radiation damage. Magnetic Resonance Elastography (MRE) is used as a novel noninvasive imaging method, a special Magnetic Resonance technology is utilized, propagation of mechanical waves in tissues is evaluated, information about tissue elasticity is provided, internal tissue elasticity of a human body can be visually displayed and quantified, Elastography of the tissues is achieved, image palpation becomes possible, and the method has important significance in treatment and monitoring aspects such as breast cancer detection, liver cirrhosis staging, atherosclerotic plaque, muscle injury, brain disease detection, radio frequency ablation and the like.
The invention patent with publication number CN103349551B discloses a magnetic resonance elastography method and system, comprising: step a: sending a trigger pulse signal through a magnetic resonance imaging device; step b: detecting the frequency of the trigger pulse signal through an external excitation device, and setting the vibration frequency of the external excitation device according to the frequency of the trigger pulse signal, wherein the set vibration frequency of the external excitation device is synchronous with the vibration frequency of the magnetic resonance imaging device; step c: and triggering an external excitation device through a magnetic resonance imaging device to output signals to the measured object, and acquiring an elastic image of the measured object.
Patent publication CN102782518B discloses a magnetic resonance elastography comprising applying mechanical vibrations with a vibration period (T) to a subject to be examined to generate mechanical waves in the subject. A motion sensitive magnetic resonance acquisition sequence is issued at a repetition time TR to acquire magnetic resonance signals from the subject. Such an acquisition sequence includes applying one or more phase encoding steps within an individual repetition time. The repetition time multiplied by the number of phase encodings within a repetition time is not equal to an integer multiple of the phase period. Thereby, a magnetic resonance image of the wave pattern is reconstructed from magnetic resonance signals collected in a sample space spanned by the phase and the phase encoding of the mechanical vibrations.
The above-mentioned patent describes the feature that with the current mainstream acquisition methods of MRE scanning, the TR × phase sampling number ≠ n × T period is required, since it is necessary to obtain the phase shift with this method in the case of continuous oscillation, in order to record the periodic motion. If TR × phase sampling number is n × T cycles, the cycle shift cannot be recorded. In this displacement encoding acquisition method, the initial time point of the motion sensitive gradient needs to be adjusted to generate motion phase shift in cooperation with the acquired external periodic motion. The disadvantage is that the compilation of the acquisition sequence is complex and the requirements on the gradient change of the magnetic resonance imaging equipment are high.
Disclosure of Invention
Aiming at the defects in the prior art, the invention provides a displacement acquisition method and system for magnetic resonance elastography.
According to the magnetic resonance elastography displacement acquisition method and the system provided by the invention, the scheme is as follows:
in a first aspect, a magnetic resonance elastography displacement acquisition method is provided, the method comprising:
step S1: setting an external driver, setting external trigger drive and frequency, applying shear fluctuation with certain frequency to a detection object, and generating the propagation of the shear fluctuation in the application object;
step S2: and carrying out motion coding on the shearing fluctuation, and acquiring image information of displacement of the shearing fluctuation in the detection object along with time and space changes.
Preferably, the step S1 includes:
step S1.1: the work of the driver is controlled by a vibration controller, and the trigger signal for starting vibration is realized by external trigger, which can be set in a magnetic resonance elastography scanning sequence or other external triggers;
step S1.2: aiming at the collection of the shearing fluctuation displacement at different cycle time points, the time point of starting vibration after the triggering of the driver is determined;
step S1.3: the external vibration frequency can be increased by any frequency increment in the range of 0.0001-0.1Hz according to the hardware response time delay.
Preferably, the trigger time point for starting the vibration in step S1.2 may be any time point in the collected motion cycle, and is determined by the position of the collected motion cycle phase sampling point.
Preferably, the magnetic resonance elastography signal acquisition in the step S2 includes:
step S2.1: adding a motion sensitive gradient MEG in an imaging sequence to encode motion displacement; the motion sensitive gradient frequency is consistent with or inconsistent with the vibration frequency of the driver;
step S2.2: the method comprises the steps that n phase acquisition points are needed for acquisition of a period of displacement, the whole magnetic resonance elastography acquisition comprises n continuous time sequence modules, and each time sequence module acquires a specific motion phase acquisition point;
step S2.3: if the starting time of the motion sensitive gradient MEG is taken as a relative time reference point, the occurrence time point of the external trigger point is changed by adding different time delay time, the external trigger point can trigger the external driver to generate continuous external vibration, and the starting time of the external vibration is different due to different time points of the external trigger point, so that different displacement phase acquisition points are acquired; during acquisition, the product of the repetition time TR and the number of applied motion sensitive gradient MEG steps is an integer multiple of the acquisition vibration period.
Preferably, said step S2.1 comprises: the loading direction of the motion sensitive gradient MEG is any one or more of a plurality of gradient directions, wherein the gradient directions comprise layer selection, phase encoding and frequency encoding; the imaging sequence is any existing imaging sequence.
Preferably, the step S2.2 includes: the imaging sequences in each timing module are substantially similar, the only difference being the point in time at which the external trigger point occurs, and the scan sequence is set by the magnetic resonance controller to satisfy the external trigger signal generation and control of the scan gradients and RF pulses in step S1.
In a second aspect, there is provided a magnetic resonance elastography displacement acquisition system, the system comprising:
module M1: setting an external driver, setting external trigger drive and frequency, applying shear fluctuation with certain frequency to a detection object, and generating the propagation of the shear fluctuation in the application object;
module M2: and carrying out motion coding on the shearing fluctuation, and acquiring image information of displacement of the shearing fluctuation in the detection object along with time and space changes.
Preferably, the module M1 includes:
module M1.1: the work of the driver is controlled by a vibration controller, and the trigger signal for starting vibration is realized by external trigger, which can be set in a magnetic resonance elastography scanning sequence or other external triggers;
module M1.2: aiming at the collection of the shearing fluctuation displacement at different cycle time points, the time point of starting vibration after the triggering of the driver is determined;
module M1.3: the external vibration frequency can be increased by any frequency increment in the range of 0.0001-0.1Hz according to the hardware response time delay.
Preferably, the triggering time point of the module M1.2 for starting oscillation can be any time point in the collected motion cycle, and is determined by the collected motion cycle phase sampling point position.
Preferably, the acquiring of magnetic resonance elastography signals in the module M2 includes:
module M2.1: adding a motion sensitive gradient MEG in an imaging sequence to encode motion displacement; the motion sensitive gradient frequency is consistent with or inconsistent with the vibration frequency of the driver;
module M2.2: the method comprises the steps that n phase acquisition points are needed for acquisition of a period of displacement, the whole magnetic resonance elastography acquisition comprises n continuous time sequence modules, and each time sequence module acquires a specific motion phase acquisition point;
module M2.3: if the starting time of the motion sensitive gradient MEG is taken as a relative time reference point, the occurrence time point of the external trigger point is changed by adding different time delay time, the external trigger point can trigger the external driver to generate continuous external vibration, and the starting time of the external vibration is different due to different time points of the external trigger point, so that different displacement phase acquisition points are acquired; during acquisition, the product of the repetition time TR and the number of applied motion sensitive gradient MEG steps is an integer multiple of the acquisition vibration period.
Compared with the prior art, the invention has the following beneficial effects:
1. by adopting the method of changing the vibration starting time point of the external driver, the acquisition of sampling points with different motion phases of periodic displacement in the elastography is solved, and the flexible recording and motion coding of the periodic displacement are better realized;
2. the motion sensitive gradient period change of the collected sequence does not need to be interrupted, the sequence portability is good, the collected motion phase shift is realized by triggering an external driver, and the motion sensitive gradient does not need to be matched with external periodic motion for phase shift.
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Other features, objects and advantages of the invention will become more apparent upon reading of the detailed description of non-limiting embodiments with reference to the following drawings:
FIG. 1 is a schematic view of the overall scheme of the present invention;
figure 2 is a schematic diagram of the timing and triggering of a displacement acquisition for magnetic resonance elastography.
Detailed Description
The present invention will be described in detail with reference to specific examples. The following examples will assist those skilled in the art in further understanding the invention, but are not intended to limit the invention in any way. It should be noted that it would be obvious to those skilled in the art that various changes and modifications can be made without departing from the spirit of the invention. All falling within the scope of the present invention.
The embodiment of the invention provides a displacement acquisition method and system for magnetic resonance elastography, and as shown in figure 1, firstly, an external driver is arranged, external trigger drive and frequency are set, shear fluctuation with certain frequency is applied to a detected object, and propagation of the shear fluctuation is generated in the applied object.
Specifically, the operation of the driver is controlled by a vibration controller, which initiates the triggering signal of the vibration, which is realized by an external trigger, which can be a trigger set in the magnetic resonance elastography scanning sequence, or other external triggers.
The acquisition of the shear wave displacement at different cycle time points is determined by the time point at which the vibration starts after the triggering of the driver. The triggering time point for starting vibration can be any time point in the collected motion period, and is determined by the position of the collected motion period phase sampling point.
The external vibration frequency may be increased by any small frequency increment in the range of 0.0001-0.1Hz for possible hardware response time delays to ensure stable continuous triggering of the vibration.
And secondly, carrying out motion coding on the shearing fluctuation, and acquiring image information of displacement of the shearing fluctuation in the detection object along with time and space changes.
Magnetic resonance elastography signal acquisition includes: adding a motion sensitive gradient MEG in an imaging sequence to encode motion displacement; the motion sensitive gradient frequency may or may not coincide with the vibration frequency of the drive. The direction of the motion sensitive gradient MEG loading may be any one or several of the three gradient directions (slice selection, phase encoding, frequency encoding). The imaging sequence may be any existing imaging sequence, such as a gradient echo, spin echo, EPI sequence, or the like.
The acquisition of a period of displacement requires n phase acquisition points, the whole magnetic resonance elastography acquisition comprises n continuous time sequence modules, and each time sequence module acquires a specific motion phase acquisition point.
The imaging sequences in each timing module are substantially similar, the only difference being the point in time at which the external trigger point occurs, and the scan sequence is set by the magnetic resonance controller to satisfy the external trigger signal generation and control of the scan gradients and RF pulses in step S1.
If the starting time of the motion sensitive gradient MEG is taken as a relative time reference point, the occurrence time point of the external trigger point is changed by adding different time delay time, the external trigger point can trigger the external driver to generate continuous external vibration, and the starting time of the external vibration is different due to different time points of the external trigger point, so that different displacement phase acquisition points are acquired; during acquisition, the product of each repetition time TR and the number of applied motion sensitive gradient MEG steps is an integer multiple of the acquisition vibration period.
Next, the present invention will be described in more detail.
Referring to fig. 2, assuming that n phase acquisition points are required for a period of displacement acquisition, the entire mri acquisition will contain n consecutive time series modules, each acquiring a specific motion phase acquisition point. The imaging sequences in each time sequential module are substantially similar, the only difference being the point in time at which the external trigger point occurs. If the start time of the motion sensitive gradient MEG is taken as a relative temporal reference point, the point in time of occurrence of the external trigger point is changed by adding a different time delay. The external trigger point triggers the external driver to generate continuous external vibration, and the time points of the external trigger point cause different starting times of the external vibration, so that different displacement phase acquisition points can be acquired. During the acquisition, each repetition time TR is an integer multiple of the period of the external vibration.
The embodiment of the invention provides a displacement acquisition method and a system for magnetic resonance elastography, the provided acquisition mode is to match discontinuous periodic vibration of an electromagnetic driver, and the periodic vibration of phase coding is realized by matching with external triggering of an acquisition sequence, so as to record periodic displacement, therefore, the acquisition mode of the invention needs TR multiplied by phase sampling number which is n multiplied by T period, and the invention has the main advantages that the motion sensitive gradient periodic change of the acquisition sequence does not need to be interrupted, and the sequence portability is good; the acquired motion phase shift is achieved by triggering an external driver, and the motion sensitive gradient does not need to be matched with external periodic motion for phase shift.
Those skilled in the art will appreciate that, in addition to implementing the system and its various devices, modules, units provided by the present invention as pure computer readable program code, the system and its various devices, modules, units provided by the present invention can be fully implemented by logically programming method steps in the form of logic gates, switches, application specific integrated circuits, programmable logic controllers, embedded microcontrollers and the like. Therefore, the system and various devices, modules and units thereof provided by the invention can be regarded as a hardware component, and the devices, modules and units included in the system for realizing various functions can also be regarded as structures in the hardware component; means, modules, units for performing the various functions may also be regarded as structures within both software modules and hardware components for performing the method.
The foregoing description of specific embodiments of the present invention has been presented. It is to be understood that the present invention is not limited to the specific embodiments described above, and that various changes or modifications may be made by one skilled in the art within the scope of the appended claims without departing from the spirit of the invention. The embodiments and features of the embodiments of the present application may be combined with each other arbitrarily without conflict.
Claims (10)
1. A displacement acquisition method for magnetic resonance elastography is characterized by comprising the following steps:
step S1: setting an external driver, setting external trigger drive and frequency, applying shear fluctuation with certain frequency to a detection object, and generating the propagation of the shear fluctuation in the application object;
step S2: and carrying out motion coding on the shearing fluctuation, and acquiring image information of displacement of the shearing fluctuation in the detection object along with time and space changes.
2. The magnetic resonance elastography displacement acquisition method as claimed in claim 1, wherein said step S1 comprises:
step S1.1: the work of the driver is controlled by a vibration controller, and the trigger signal for starting vibration is realized by external trigger, which can be set in a magnetic resonance elastography scanning sequence or other external triggers;
step S1.2: aiming at the collection of the shearing fluctuation displacement at different cycle time points, the time point of starting vibration after the triggering of the driver is determined;
step S1.3: the external vibration frequency can be increased by any frequency increment in the range of 0.0001-0.1Hz according to the hardware response time delay.
3. The method according to claim 2, wherein the triggering time point for starting oscillation in step S1.2 can be any time point in the acquired motion cycle, and is determined by the position of the phase sampling point of the acquired motion cycle.
4. The magnetic resonance elastography displacement acquisition method as claimed in claim 1, wherein the magnetic resonance elastography signal acquisition in step S2 comprises:
step S2.1: adding a motion sensitive gradient MEG in an imaging sequence to encode motion displacement; the motion sensitive gradient frequency is consistent with or inconsistent with the vibration frequency of the driver;
step S2.2: the method comprises the steps that n phase acquisition points are needed for acquisition of a period of displacement, the whole magnetic resonance elastography acquisition comprises n continuous time sequence modules, and each time sequence module acquires a specific motion phase acquisition point;
step S2.3: if the starting time of the motion sensitive gradient MEG is taken as a relative time reference point, the occurrence time point of the external trigger point is changed by adding different time delay time, the external trigger point can trigger the external driver to generate continuous external vibration, and the starting time of the external vibration is different due to different time points of the external trigger point, so that different displacement phase acquisition points are acquired; during acquisition, the product of the repetition time TR and the number of applied motion sensitive gradient MEG steps is an integer multiple of the acquisition vibration period.
5. The magnetic resonance elastography displacement acquisition method of claim 4, wherein the step S2.1 comprises: the loading direction of the motion sensitive gradient MEG is any one or more of a plurality of gradient directions, wherein the gradient directions comprise layer selection, phase encoding and frequency encoding; the imaging sequence is any existing imaging sequence.
6. The magnetic resonance elastography displacement acquisition method of claim 4, wherein the step S2.2 comprises: the imaging sequences in each timing module are substantially similar, the only difference being the point in time at which the external trigger point occurs, and the scan sequence is set by the magnetic resonance controller to satisfy the external trigger signal generation and control of the scan gradients and RF pulses in step S1.
7. A magnetic resonance elastography displacement acquisition system, comprising:
module M1: setting an external driver, setting external trigger drive and frequency, applying shear fluctuation with certain frequency to a detection object, and generating the propagation of the shear fluctuation in the application object;
module M2: and carrying out motion coding on the shearing fluctuation, and acquiring image information of displacement of the shearing fluctuation in the detection object along with time and space changes.
8. The magnetic resonance elastography displacement acquisition system of claim 7, wherein the module M1 comprises:
module M1.1: the work of the driver is controlled by a vibration controller, and the trigger signal for starting vibration is realized by external trigger, which can be set in a magnetic resonance elastography scanning sequence or other external triggers;
module M1.2: aiming at the collection of the shearing fluctuation displacement at different cycle time points, the time point of starting vibration after the triggering of the driver is determined;
module M1.3: the external vibration frequency can be increased by any frequency increment in the range of 0.0001-0.1Hz according to the hardware response time delay.
9. The system according to claim 8, wherein the triggering time point of the module M1.2 to start oscillation can be any time point in the acquired motion period, which is determined by the position of the phase sampling point of the acquired motion period.
10. The system according to claim 7, wherein the module M2 for magnetic resonance elastography signal acquisition comprises:
module M2.1: adding a motion sensitive gradient MEG in an imaging sequence to encode motion displacement; the motion sensitive gradient frequency is consistent with or inconsistent with the vibration frequency of the driver;
module M2.2: the method comprises the steps that n phase acquisition points are needed for acquisition of a period of displacement, the whole magnetic resonance elastography acquisition comprises n continuous time sequence modules, and each time sequence module acquires a specific motion phase acquisition point;
module M2.3: if the starting time of the motion sensitive gradient MEG is taken as a relative time reference point, the occurrence time point of the external trigger point is changed by adding different time delay time, the external trigger point can trigger the external driver to generate continuous external vibration, and the starting time of the external vibration is different due to different time points of the external trigger point, so that different displacement phase acquisition points are acquired; during acquisition, the product of the repetition time TR and the number of applied motion sensitive gradient MEG steps is an integer multiple of the acquisition vibration period.
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