CN113662189A - Plant extract tablet and preparation method thereof - Google Patents
Plant extract tablet and preparation method thereof Download PDFInfo
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- CN113662189A CN113662189A CN202111095138.0A CN202111095138A CN113662189A CN 113662189 A CN113662189 A CN 113662189A CN 202111095138 A CN202111095138 A CN 202111095138A CN 113662189 A CN113662189 A CN 113662189A
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- plant extract
- collagen
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- 239000000419 plant extract Substances 0.000 title claims abstract description 50
- 238000002360 preparation method Methods 0.000 title abstract description 20
- 102000008186 Collagen Human genes 0.000 claims description 60
- 108010035532 Collagen Proteins 0.000 claims description 60
- 229920001436 collagen Polymers 0.000 claims description 60
- 238000003756 stirring Methods 0.000 claims description 43
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 34
- 239000002245 particle Substances 0.000 claims description 34
- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical compound OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 claims description 24
- 239000012752 auxiliary agent Substances 0.000 claims description 22
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 21
- 238000002156 mixing Methods 0.000 claims description 19
- CTENFNNZBMHDDG-UHFFFAOYSA-N Dopamine hydrochloride Chemical compound Cl.NCCC1=CC=C(O)C(O)=C1 CTENFNNZBMHDDG-UHFFFAOYSA-N 0.000 claims description 12
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 12
- 229960001149 dopamine hydrochloride Drugs 0.000 claims description 12
- 229940074391 gallic acid Drugs 0.000 claims description 12
- 235000004515 gallic acid Nutrition 0.000 claims description 12
- 235000011187 glycerol Nutrition 0.000 claims description 12
- 235000012424 soybean oil Nutrition 0.000 claims description 12
- 239000003549 soybean oil Substances 0.000 claims description 12
- 239000002131 composite material Substances 0.000 claims description 11
- NIQCNGHVCWTJSM-UHFFFAOYSA-N Dimethyl phthalate Chemical compound COC(=O)C1=CC=CC=C1C(=O)OC NIQCNGHVCWTJSM-UHFFFAOYSA-N 0.000 claims description 10
- 239000000284 extract Substances 0.000 claims description 10
- 239000012065 filter cake Substances 0.000 claims description 10
- 238000004108 freeze drying Methods 0.000 claims description 10
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims description 10
- 238000000967 suction filtration Methods 0.000 claims description 10
- 239000000725 suspension Substances 0.000 claims description 10
- 238000005406 washing Methods 0.000 claims description 10
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 9
- 239000000853 adhesive Substances 0.000 claims description 9
- 230000001070 adhesive effect Effects 0.000 claims description 9
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 9
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 9
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 9
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- 235000010413 sodium alginate Nutrition 0.000 claims description 8
- 239000000661 sodium alginate Substances 0.000 claims description 8
- 229940005550 sodium alginate Drugs 0.000 claims description 8
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims description 6
- 229910021538 borax Inorganic materials 0.000 claims description 6
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 6
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 6
- 235000010339 sodium tetraborate Nutrition 0.000 claims description 6
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 claims description 6
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 claims description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 5
- 239000000908 ammonium hydroxide Substances 0.000 claims description 5
- FBSAITBEAPNWJG-UHFFFAOYSA-N dimethyl phthalate Natural products CC(=O)OC1=CC=CC=C1OC(C)=O FBSAITBEAPNWJG-UHFFFAOYSA-N 0.000 claims description 5
- 229960001826 dimethylphthalate Drugs 0.000 claims description 5
- 239000005457 ice water Substances 0.000 claims description 5
- 239000012299 nitrogen atmosphere Substances 0.000 claims description 5
- 239000000376 reactant Substances 0.000 claims description 5
- 238000001694 spray drying Methods 0.000 claims description 5
- 239000001384 succinic acid Substances 0.000 claims description 5
- 238000009210 therapy by ultrasound Methods 0.000 claims description 5
- 239000011230 binding agent Substances 0.000 claims description 4
- 241000371652 Curvularia clavata Species 0.000 claims description 3
- 240000000249 Morus alba Species 0.000 claims description 3
- 235000008708 Morus alba Nutrition 0.000 claims description 3
- 235000019216 blueberry extract Nutrition 0.000 claims description 3
- 229940055416 blueberry extract Drugs 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 244000017020 Ipomoea batatas Species 0.000 claims description 2
- 235000002678 Ipomoea batatas Nutrition 0.000 claims description 2
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims description 2
- 235000019700 dicalcium phosphate Nutrition 0.000 claims description 2
- 239000003607 modifier Substances 0.000 claims description 2
- 239000008187 granular material Substances 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 11
- 239000000463 material Substances 0.000 abstract description 6
- 239000004480 active ingredient Substances 0.000 abstract description 5
- 235000013305 food Nutrition 0.000 abstract description 4
- 230000000052 comparative effect Effects 0.000 description 9
- 239000002994 raw material Substances 0.000 description 5
- 238000005507 spraying Methods 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 3
- 239000002318 adhesion promoter Substances 0.000 description 3
- 125000003277 amino group Chemical group 0.000 description 3
- 229910052791 calcium Inorganic materials 0.000 description 3
- 239000011575 calcium Substances 0.000 description 3
- 239000002775 capsule Substances 0.000 description 3
- 230000000875 corresponding effect Effects 0.000 description 3
- 238000007908 dry granulation Methods 0.000 description 3
- 238000007873 sieving Methods 0.000 description 3
- 238000001132 ultrasonic dispersion Methods 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 2
- 239000012295 chemical reaction liquid Substances 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
- 238000005096 rolling process Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 235000016357 Mirtillo rosso Nutrition 0.000 description 1
- 244000077923 Vaccinium vitis idaea Species 0.000 description 1
- 235000017606 Vaccinium vitis idaea Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/015—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/03—Organic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/03—Organic compounds
- A23L29/035—Organic compounds containing oxygen as heteroatom
- A23L29/04—Fatty acids or derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/03—Organic compounds
- A23L29/045—Organic compounds containing nitrogen as heteroatom
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
- A23L29/37—Sugar alcohols
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
- A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
Abstract
The invention discloses a plant extract tablet and a preparation method thereof, and relates to the technical field of special-purpose food. According to the plant extract tablet and the preparation method thereof, the dosage of auxiliary materials is small, the content of active ingredients is high and can reach more than 90%, and on the premise of achieving the same effect, fewer tablets are required.
Description
Technical Field
The invention relates to the technical field of special-purpose food, in particular to a plant extract tablet and a preparation method thereof.
Background
The plant extract is a product formed by taking plants as raw materials, directionally obtaining and concentrating one or more active ingredients in the plants through a physical and chemical extraction and separation process according to the requirements of the application of an extracted final product without changing the structures of the active ingredients, and is widely applied to medicines and health-care foods because the plant extract has higher marking components and better treatment and health-care effects, wherein the tablet is the most common preparation form in the health-care foods and the medicines, has high content of effective components, good treatment and health-care effects and is convenient to take and carry.
Most of the existing plant extract tablets are prepared by adding various auxiliary materials such as a binder, a disintegrating agent and the like into the plant extract and tabletting. In order to ensure that the prepared tablets meet corresponding requirements, the content of auxiliary materials is mostly over 30 percent, so that the content of effective ingredients of a single tablet is reduced, and more tablets are often needed to be taken in order to achieve corresponding effects.
Disclosure of Invention
In view of the above problems, the present invention aims to provide a plant extract tablet and a preparation method thereof, wherein the dosage of the auxiliary materials is small, the content of the active ingredients is high and can reach more than 90%, and on the premise of achieving the same effect, fewer tablets are required.
The invention solves the technical problems by the following technical means:
a plant extract tablet is prepared from plant extract and composite adhesive through mixing, granulating and tabletting, and the composite adhesive contains soybean oil, glycerin and adhesive assistant particles.
Further, the mass fraction of the composite binder in the tablet is 6-10%.
Furthermore, the mass ratio of the soybean oil to the glycerol to the bonding auxiliary agent particles is 2:1 (2-2.5).
Furthermore, the bonding auxiliary agent particles are microcapsules taking microcrystalline cellulose/modified collagen composite solution as capsule cores and sodium alginate as capsule shells.
Furthermore, the modified collagen is prepared by taking gallic acid and dopamine hydrochloride as modifiers and grafting and modifying natural collagen.
The adhesion auxiliary agent particle of the invention introduces gallic acid and dopamine hydrochloride as active side chain structures on natural collagen, thereby introducing phenolic hydroxyl and amino groups on the natural collagen, the introduction of the phenolic hydroxyl can increase the effect of forming hydrogen bonds between the natural collagen and water molecules, improve the water solubility of modified collagen, further increase the water solubility of tablets, and simultaneously the introduction of the phenolic hydroxyl and the amino groups can also improve the bonding performance of the modified collagen, in the preparation process of the tablets, under the pressure effect, the capsule skin of the adhesion auxiliary agent particle is broken, the internal modified collagen solution is dissolved out, the infiltration is generated between the adhesion auxiliary agent particle and other raw materials, the adhesion effect is firstly utilized to be combined with other raw materials, then the modified collagen is crosslinked, a reticular structure is formed to bond other materials together, thereby achieving the effect of using a small amount of adhesive to prepare tablets, meanwhile, the microcrystalline cellulose can be used as reinforcing particles with a net-shaped cross-linked structure, so that the hardness of the prepared tablet is improved.
In addition, as phenolic hydroxyl groups on gallic acid are easy to oxidize and lose effects, the invention protects the gallic acid in the form of microcapsules so as to ensure the action effect of the gallic acid, and raw materials such as microcrystalline cellulose, sodium alginate and the like in the adhesion auxiliary agent particles also have certain adhesion performance and can assist in increasing the adhesion to a certain degree.
Further, the plant extract is any one of blueberry extract, cowberry extract, mulberry extract, black rice extract and purple sweet potato extract.
In addition, the invention also discloses a preparation method of the plant extract tablet, which comprises the following steps: according to the proportion, soybean oil, glycerol and bonding auxiliary agent particles are respectively taken, stirred and mixed uniformly, ultrasonically dispersed, sprayed into the plant extract by a nozzle, mixed for 15min, granulated by a dry method, and finally tableted to obtain the plant extract tablet.
Further, the preparation method of the bonding auxiliary agent particles comprises the following steps: adding the modified collagen into a sodium alginate solution, stirring and mixing uniformly, adding microcrystalline cellulose, performing ultrasonic treatment for 30min to obtain a suspension, then sequentially adding a succinic acid solution, an ammonium hydroxide solution and a calcium hydrogen phosphate solution into the suspension, stirring and mixing uniformly, and performing spray drying to obtain the bonding auxiliary agent particles.
Further, the preparation method of the modified collagen comprises the following steps:
pretreatment: dissolving natural collagen in 1-butyl-3-methyl halogenated imidazole under stirring, magnetically stirring until the solution is clear, adding dimethyl phthalate, magnetically stirring for reaction for 12h, and pouring the reactant into cold diethyl ether; carrying out ice water bath for 1h, carrying out suction filtration, washing a filter cake with cold ether for three times, and carrying out freeze drying to obtain a pretreated collagen; grafting: respectively adding sodium borate and sodium bicarbonate into N-methylpyrrolidone, stirring for 20-30min, adding dopamine hydrochloride and gallic acid, continuously stirring for 30min, adding pretreated collagen, continuously stirring and reacting for 20-24h under the nitrogen atmosphere, after the reaction is finished, adjusting the pH to 5-6, settling the obtained reaction solution with absolute ethyl alcohol, carrying out suction filtration, washing the obtained filter cake, and freeze-drying to obtain the modified collagen.
The invention has the beneficial effects that:
1. the plant extract tablet provided by the invention has the advantages that the dosage of auxiliary materials is small, the content of active ingredients is high and can reach more than 90%, and on the premise of achieving the same effect, fewer tablets are required.
2. According to the plant extract tablet, the binding aid particles are used, so that the prepared tablet is high in hardness and smooth in surface, and the requirements of subsequent operations such as coating are met.
3. According to the bonding auxiliary agent particles, natural collagen is modified, phenolic hydroxyl groups and amino groups are introduced, the bonding capacity of the particles is effectively improved, the corresponding tabletting requirements can be met by adding a small amount of the particles, and the used raw materials are all natural environment-friendly substances, are wide in source, are green and are healthy.
Detailed Description
The present invention will be described in detail with reference to specific examples below:
the invention relates to a plant extract tablet, which is prepared by mixing a plant extract and a composite adhesive, granulating and tabletting, wherein the mass fraction of the composite adhesive is 6-10%, the composite adhesive comprises soybean oil, glycerol and adhesion auxiliary agent particles, and the plant extract tablet specifically comprises the following components:
example one
Preparation of modified collagen
Pretreatment: taking natural collagen, stirring and dissolving the natural collagen in 1-butyl-3-methyl halogenated imidazole with the mass 4 times that of the natural collagen, magnetically stirring until the solution is clear, adding dimethyl phthalate with the mass 1/2 times that of the natural collagen, magnetically stirring and reacting for 12 hours, pouring reactants into cold ether, carrying out ice water bath for 1 hour, carrying out suction filtration, washing a filter cake with the cold ether for three times, and carrying out freeze drying to obtain pretreated collagen;
grafting: respectively adding sodium borate and sodium bicarbonate into N-methylpyrrolidone, stirring for 20min, adding dopamine hydrochloride and gallic acid, wherein the mass ratio of the N-methylpyrrolidone to the sodium borate to the sodium bicarbonate to the dopamine hydrochloride to the gallic acid is 4:0.6:1:3:2, continuously stirring for 30min, adding pretreatment collagen with the mass 2 times that of the dopamine hydrochloride, continuously stirring and reacting for 22h under the nitrogen atmosphere, after the reaction is finished, adjusting the pH to 5-6, obtaining a reaction solution, settling with absolute ethyl alcohol, performing suction filtration, washing a filter cake, and freeze-drying to obtain the modified collagen.
Preparation of adhesion promoter particles
Adding the modified collagen into a sodium alginate solution, stirring and mixing uniformly, adding microcrystalline cellulose with the mass of 0.1 time that of the modified collagen, carrying out ultrasonic treatment for 30min to obtain a suspension, then sequentially adding a succinic acid solution, an ammonium hydroxide solution and a calcium hydrophosphate solution into the suspension, stirring and mixing uniformly, and carrying out spray drying to obtain the bonding auxiliary agent particles.
Preparation of plant extract tablet
Respectively taking soybean oil, glycerol and bonding auxiliary agent particles according to the mass ratio of 2:1:2.5, stirring and mixing uniformly, performing ultrasonic dispersion, spraying the mixture into the blueberry extract by using a nozzle, wherein the total spraying amount is 8 percent of the plant extract, mixing for 15min, performing dry granulation under the conditions of 5MPa of pressure and 12rpm of rotating speed, sieving by using a 18-mesh sieve, and finally tabletting to obtain the plant extract tablet.
Example two
Preparation of modified collagen
Pretreatment: taking natural collagen, stirring and dissolving the natural collagen in 1-butyl-3-methyl halogenated imidazole with the mass 5 times that of the natural collagen, magnetically stirring until the solution is clear, adding dimethyl phthalate with the mass 1/2 times that of the natural collagen, magnetically stirring and reacting for 12 hours, pouring reactants into cold ether, carrying out ice water bath for 1 hour, carrying out suction filtration, washing a filter cake with the cold ether for three times, and carrying out freeze drying to obtain pretreated collagen;
grafting: respectively adding sodium borate and sodium bicarbonate into N-methylpyrrolidone, stirring for 25min, adding dopamine hydrochloride and gallic acid, continuously stirring for 30min, adding pretreatment collagen with the mass 2 times that of the dopamine hydrochloride, continuously stirring and reacting for 20h under the nitrogen atmosphere, after the reaction is finished, adjusting the pH to 5-6, settling the obtained reaction liquid with absolute ethyl alcohol, carrying out suction filtration, washing the obtained filter cake, and freeze-drying to obtain the modified collagen.
Preparation of adhesion promoter particles
Adding the modified collagen into a sodium alginate solution, stirring and mixing uniformly, adding microcrystalline cellulose with the mass of 0.1 time that of the modified collagen, carrying out ultrasonic treatment for 30min to obtain a suspension, then sequentially adding a succinic acid solution, an ammonium hydroxide solution and a calcium hydrophosphate solution into the suspension, stirring and mixing uniformly, and carrying out spray drying to obtain the bonding auxiliary agent particles.
Preparation of plant extract tablet
Respectively taking soybean oil, glycerol and bonding auxiliary agent particles according to the mass ratio of 2:1:2.2, stirring and mixing uniformly, performing ultrasonic dispersion, spraying the soybean oil, the glycerol and the bonding auxiliary agent particles into mulberry extract by using a nozzle, wherein the total spraying amount is 6 percent of the plant extract, mixing for 15min, performing dry granulation under the conditions of the pressure of 5MPa and the rotating speed of 12rpm, sieving by using a 18-mesh sieve, finally tabletting to obtain plant extract tablets, and finally tabletting to obtain the plant extract tablets.
EXAMPLE III
Preparation of modified collagen
Pretreatment: taking natural collagen, stirring and dissolving the natural collagen in 1-butyl-3-methyl halogenated imidazole with the mass 3 times that of the natural collagen, magnetically stirring until the solution is clear, adding dimethyl phthalate with the mass 1/2 times that of the natural collagen, magnetically stirring and reacting for 12 hours, pouring reactants into cold ether, carrying out ice water bath for 1 hour, carrying out suction filtration, washing a filter cake with the cold ether for three times, and carrying out freeze drying to obtain pretreated collagen;
grafting: respectively adding sodium borate and sodium bicarbonate into N-methylpyrrolidone, stirring for 20min, adding dopamine hydrochloride and gallic acid, continuously stirring for 30min, adding pretreatment collagen with the mass of 2 times that of the dopamine hydrochloride, continuously stirring and reacting for 24h under the nitrogen atmosphere, after the reaction is finished, adjusting the pH to 5-6, settling the obtained reaction liquid with absolute ethyl alcohol, carrying out suction filtration, washing the obtained filter cake, and freeze-drying to obtain the modified collagen.
Preparation of adhesion promoter particles
Adding the modified collagen into a sodium alginate solution, stirring and mixing uniformly, adding microcrystalline cellulose with the mass of 0.1 time that of the modified collagen, carrying out ultrasonic treatment for 30min to obtain a suspension, then sequentially adding a succinic acid solution, an ammonium hydroxide solution and a calcium hydrophosphate solution into the suspension, stirring and mixing uniformly, and carrying out spray drying to obtain the bonding auxiliary agent particles.
Preparation of plant extract tablet
Respectively taking soybean oil, glycerol and bonding auxiliary agent particles according to the mass ratio of 2:1:2, stirring and mixing uniformly, performing ultrasonic dispersion, spraying the soybean oil, the glycerol and the bonding auxiliary agent particles into the black rice extract by using a nozzle, mixing for 15min, performing dry granulation under the conditions of pressure of 5MPa and rotating speed of 12rpm, sieving by using a 18-mesh sieve, tabletting to obtain plant extract tablets, and tabletting to obtain the plant extract tablets.
Comparative example 1
The comparative example is different from the first example in that the comparative example replaces the modified collagen with the conventional collagen.
Comparative example No. two
This comparative example is different from example one in that no binder aid particles are added.
First, disintegration time limit detection
Taking the plant extract tablets prepared in the first to third embodiments, and detecting the disintegration time limit, namely, using the equipment in the prior art, hanging the basket on a metal support through a stainless steel shaft at the upper end, immersing the basket in a 1000ml beaker, adjusting the position of the basket to enable the basket to descend, enabling a screen to be 25mm away from the bottom of the beaker, filling water with the temperature of 37 s and 1 ℃ in the beaker, adjusting the liquid level to enable the screen to be 15mm below the liquid level when the basket ascends, taking the plant extract tablets, respectively placing the plant extract tablets in glass tubes of the basket, adding 1 tablet in each tube, marking, immediately starting a disintegration instrument for inspection, and detecting results are shown in table 1:
TABLE 1 disintegration time limit
As can be seen from the data in Table 1, the disintegration time of the plant extract tablet prepared by the invention is below 20min, the disintegration is fast, the related regulations are met, and the modified collagen of the invention can effectively shorten the disintegration time of the extract tablet as can be seen from the data of the examples and the comparative examples.
Second, hardness and friability measurement
The plant extract tablets prepared in examples one to three were measured for hardness using a tablet hardness tester, and the friability was measured using a tablet friability tester by placing the plant extract tablets in a cylinder and rolling the tablets 100 times, with the test results shown in table 2:
TABLE 2 hardness, friability
| Item | Hardness per kg | Weight loss/%) | Appearance after rolling |
| Example one | 5.2 | 0.7 | Intact appearance, no fracture, crack and shattered sheet |
| Example two | 5.0 | 0.6 | Intact appearance, no fracture, crack and shattered sheet |
| EXAMPLE III | 5.1 | 0.9 | Intact appearance, no fracture, crack and shattered sheet |
| Comparative example 1 | 3.9 | 1.3 | Intact appearance, no fracture, shattered pieces |
| Comparative example No. two | 2.5 | 5 | Intact appearance, cracked, crumbled pieces |
As can be seen from the data in Table 2, the hardness of the plant extract tablet prepared by the invention is higher, the brittleness detection meets the relevant regulations, and the comparison between the examples and the comparative examples shows that the hardness of the plant extract tablet can be effectively improved by adopting the bonding auxiliary agent particles of the invention.
Although the present invention has been described in detail with reference to the preferred embodiments, it will be understood by those skilled in the art that various changes may be made and equivalents may be substituted without departing from the spirit and scope of the invention as defined in the appended claims. The techniques, shapes, and configurations not described in detail in the present invention are all known techniques.
Claims (9)
1. The plant extract tablet is characterized in that the tablet is prepared by mixing plant extract and a composite adhesive, granulating and tabletting, wherein the composite adhesive comprises soybean oil, glycerol and bonding auxiliary particles.
2. The plant extract tablet as claimed in claim 1, wherein the mass fraction of the composite binder in the tablet is 6% to 10%.
3. The plant extract tablet as claimed in claim 2, wherein the mass ratio of the soybean oil, the glycerin and the binding aid granules is 4:2 (1-1.5).
4. A plant extract tablet according to any one of claims 1 to 3, wherein the binding aid particles are microcapsules having a core of microcrystalline cellulose/modified collagen composite solution and a shell of microcrystalline cellulose-doped sodium alginate.
5. The plant extract tablet according to claim 4, wherein the modified collagen is obtained by graft modification of natural collagen using gallic acid and dopamine hydrochloride as a modifier.
6. The plant extract tablet as claimed in claim 5, wherein the plant extract is any one of blueberry extract, mulberry extract, black rice extract and purple sweet potato extract.
7. The method of producing a plant extract tablet according to any one of claims 1 to 6, wherein the method comprises: according to the proportion, soybean oil, glycerol and bonding auxiliary agent particles are respectively taken, stirred and mixed uniformly, ultrasonically dispersed, sprayed into the plant extract by a nozzle, mixed for 15min, granulated by a dry method, and finally tableted to obtain the plant extract tablet.
8. The method of claim 7, wherein the binding aid particles are prepared by: adding the modified collagen into a sodium alginate solution, stirring and mixing uniformly, adding microcrystalline cellulose, performing ultrasonic treatment for 30min to obtain a suspension, then sequentially adding a succinic acid solution, an ammonium hydroxide solution and a calcium hydrogen phosphate solution into the suspension, stirring and mixing uniformly, and performing spray drying to obtain the bonding auxiliary agent particles.
9. The method of claim 8, wherein the modified collagen is prepared by:
pretreatment: taking natural collagen, stirring and dissolving the natural collagen in 1-butyl-3-methyl halogenated imidazole, magnetically stirring until the solution is clear, adding dimethyl phthalate, magnetically stirring and reacting for 12 hours, pouring reactants into cold ether, carrying out ice water bath for 1 hour, carrying out suction filtration, washing a filter cake for three times by using the cold ether, and carrying out freeze drying to obtain pretreated collagen;
grafting: respectively adding sodium borate and sodium bicarbonate into N-methylpyrrolidone, stirring for 20-30min, adding dopamine hydrochloride and gallic acid, continuously stirring for 30min, adding pretreated collagen, continuously stirring and reacting for 20-24h under the nitrogen atmosphere, after the reaction is finished, adjusting the pH to 5-6, settling the obtained reaction solution with absolute ethyl alcohol, carrying out suction filtration, washing the obtained filter cake, and freeze-drying to obtain the modified collagen.
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| US20050214367A1 (en) * | 2004-03-22 | 2005-09-29 | Volker Kuellmer | Processes for making coated phytochemicals and tocopherols and products formed therefrom |
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