CN113647969B - Method and system for analyzing components of radioactive tracer - Google Patents

Method and system for analyzing components of radioactive tracer Download PDF

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CN113647969B
CN113647969B CN202111089497.5A CN202111089497A CN113647969B CN 113647969 B CN113647969 B CN 113647969B CN 202111089497 A CN202111089497 A CN 202111089497A CN 113647969 B CN113647969 B CN 113647969B
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target
radionuclides
determining
radionuclide
radiotracer
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CN113647969A (en
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赵一璋
叶青
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Shanghai United Imaging Healthcare Co Ltd
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Shanghai United Imaging Healthcare Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/02—Devices for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
    • A61B6/03—Computerised tomographs
    • A61B6/037—Emission tomography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/48—Diagnostic techniques
    • A61B6/481—Diagnostic techniques involving the use of contrast agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/56—Details of data transmission or power supply, e.g. use of slip rings
    • A61B6/563—Details of data transmission or power supply, e.g. use of slip rings involving image data transmission via a network
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E30/00—Energy generation of nuclear origin
    • Y02E30/30—Nuclear fission reactors

Abstract

The present application relates to a method of analysis of a radiotracer composition, the method comprising: acquiring PET scan data by PET scanning a living body injected with a radioactive tracer, a scan field of the PET scan covering an entire region of the living body containing radionuclides, the radioactive tracer containing one or more target radionuclides; determining a total activity of all radionuclides in the living body corresponding to at least two or more times not less than a target number based on the PET scan data; based on the total activity at least two times or not less than a target number of times, the number of species of the plurality of target radionuclides, component analysis results of the radiotracer with respect to the one or more target radionuclides are determined.

Description

Method and system for analyzing components of radioactive tracer
Technical Field
The application relates to the technical field of radioactive tracers, in particular to a method and a system for analyzing components of a radioactive tracer.
Background
Radiotracers, also known as radiolabels, refer to compounds that are labeled with radionuclides. Based on the radiotracer, various chemical processes, living bodies, etc. can be studied and monitored. When various chemical processes, biological processes, organisms and the like are researched and monitored, in order to obtain accurate results such as focus positions, product distribution and the like, the component conditions of radionuclides of the radioactive tracer, for example, whether other radionuclides pollute the radioactive tracer or not, and for example, the proportion of various radionuclides contained in the radioactive tracer, are required to be known, so that inaccurate results such as focus positions, product distribution and the like caused by impure radionuclides or inconsistent actual proportion of various radionuclides and preparation proportion and the like are avoided.
Thus, there is a need for a method and system for analysis of the components of a radiotracer that allows for accurate analysis of the radionuclide components of the radiotracer.
Disclosure of Invention
It is an object of the present specification to provide a method and system for analysis of the composition of a radioactive tracer, comprising one or more target radionuclides, by performing a PET scan (positron emission computed tomography scan) of a living body into which the radioactive tracer is injected, acquiring PET scan data, determining the total activity of all radionuclides in the living body corresponding to at least two or not less than a target number of moments based on the PET scan data, and determining the analysis result of the composition of the radioactive tracer in relation to the one or more target radionuclides based on the total activity of at least two moments or not less than the target number of moments.
One of the embodiments of the present specification provides a method of analysis of a radiotracer composition, the method comprising: acquiring PET scan data by PET scanning a living body injected with a radioactive tracer, a scan field of the PET scan covering an entire region of the living body containing radionuclides, the radioactive tracer containing one or more target radionuclides; determining a total activity of all radionuclides in the living body corresponding to at least two or more times not less than a target number based on the PET scan data; based on the total activity at least two times or not less than the total activity at the target number of times, determining a component analysis result of the radiotracer with respect to the one or more target radionuclides, the target number not being less than a number of nuclide species of the plurality of target radionuclides.
One of the embodiments of the present specification provides a radiotracer composition analysis system, the system comprising: an acquisition module for acquiring PET scan data by PET scanning a living body injected with a radioactive tracer, the scan field of view of the PET scan covering all areas of the living body containing radionuclides at least approximately over the whole body of the living body, the radioactive tracer containing one or more target radionuclides; the activity determining module is used for determining the total activity of all radionuclides in the living body corresponding to at least two or more times which are not less than the target number based on the PET scanning data; a component analysis module for determining a component analysis result of the radiotracer with respect to the one or more target radionuclides based on the total activity at least two times or the total activity at not less than the target number of times, the target number being not less than a number of nuclide species of the plurality of target radionuclides.
One of the embodiments of the present description provides a radiotracer component analysis apparatus comprising at least one processor and at least one storage device for storing instructions which, when executed by the at least one processor, implement the radiotracer component analysis method.
Drawings
The present specification will be further elucidated by way of example embodiments, which will be described in detail by means of the accompanying drawings. The embodiments are not limiting, in which like numerals represent like structures, wherein:
FIG. 1 is a schematic illustration of an application scenario of a radiotracer component analysis system according to some embodiments of the present description;
FIG. 2 is a block diagram of a radiotracer component analysis system according to some embodiments of the present description;
FIG. 3 is an exemplary flow chart of a method of analysis of a radiotracer composition according to some embodiments of the present description;
FIG. 4 is an exemplary flow chart of a method of determining the component analysis results of the radiotracer with respect to one or more target radionuclides, according to some embodiments of the present disclosure;
FIG. 5 is an exemplary flow chart of a method of determining the component analysis results of the radiotracer with respect to one or more target radionuclides according to other embodiments of the present disclosure;
fig. 6 is an exemplary flow chart of a method of determining the results of a compositional analysis of the radiotracer with respect to one or more target radionuclides, according to other embodiments of the present disclosure.
Detailed Description
In order to more clearly illustrate the technical solutions of the embodiments of the present specification, the drawings that are required to be used in the description of the embodiments will be briefly described below. It is apparent that the drawings in the following description are only some examples or embodiments of the present application, and it is obvious to those skilled in the art that the present application may be applied to other similar situations according to the drawings without inventive effort. Unless otherwise apparent from the context of the language or otherwise specified, like reference numerals in the figures refer to like structures or operations.
It will be appreciated that "system," "apparatus," "unit" and/or "module" as used herein is one method for distinguishing between different components, elements, parts, portions or assemblies of different levels. However, if other words can achieve the same purpose, the words can be replaced by other expressions.
As used in this specification and the claims, the terms "a," "an," "the," and/or "the" are not specific to a singular, but may include a plurality, unless the context clearly dictates otherwise. In general, the terms "comprises" and "comprising" merely indicate that the steps and elements are explicitly identified, and they do not constitute an exclusive list, as other steps or elements may be included in a method or apparatus.
A flowchart is used in this specification to describe the operations performed by the system according to embodiments of the present specification. It should be appreciated that the preceding or following operations are not necessarily performed in order precisely. Rather, the steps may be processed in reverse order or simultaneously. Also, other operations may be added to or removed from these processes.
The method and system for analysis of the components of the radioactive tracer disclosed in the specification can be applied to various application scenes related to the radioactive tracer, such as analysis of the radionuclide components of the radioactive tracer, so as to research and monitor various chemical processes, living bodies and the like based on the radioactive tracer.
In some embodiments, various chemical processes, living subjects, etc. may be studied and monitored using a radiotracer comprising a radionuclide label, for example, the radiotracer comprising a radionuclide label may be injected into a human body to observe and image a disease focus. In some embodiments, various chemical processes, living subjects, etc. may be studied and monitored using a radiotracer comprising a plurality of radionuclide labels, for example, the radiotracer comprising a plurality of radionuclide labels may be injected into a human body to effect the observation and imaging of a plurality of disease lesions. During the preparation and use of the radioactive tracer, radionuclide pollution may occur, so that radionuclides in the radioactive tracer are not pure, or the actual proportion of various radionuclides may be inconsistent with the preparation proportion due to residues during the injection of the tracer. The inaccurate identification of the radionuclide component in the tracer can cause the problems of erroneous judgment of disease focus, inaccurate monitoring analysis and the like.
In order to accurately analyze radionuclide components in a radioactive tracer, the present specification proposes a radioactive tracer component analysis method and system, for a radioactive tracer containing one or more target radionuclides, obtaining PET scan data by PET scanning (positron emission computed tomography) of a living body injected with the radioactive tracer, determining total activity of all radionuclides in the living body corresponding to at least two or not less than a target number of moments based on the PET scan data, determining component analysis results of the radioactive tracer with respect to the one or more target radionuclides based on the total activity of at least two moments or not less than the total activity of a target number of moments, the target number being not less than the number of nuclide species of the plurality of target radionuclides.
Fig. 1 is a schematic illustration of an application scenario of a radiotracer component analysis system according to some embodiments of the present description.
As shown in fig. 1, an application scenario 100 of a radiotracer component analysis system may include a PET scanning device 110, a network 120, a terminal 130, a processing device 140, and a storage device 150.
The components of the application scenario 100 of the radiotracer component analysis system may be connected in various ways. For example only, as shown in fig. 1, PET scanning device 110 may be connected to processing device 140 through network 120. As another example, PET scanning device 110 may be directly connected to processing device 140 (as indicated by the double-headed arrow in the dashed line connecting PET scanning device 110 and processing device 140). As another example, the storage device 150 may be connected to the processing device 140 directly or through the network 120. As yet another example, a terminal device (e.g., 130-1, 130-2, 130-3, etc.) may be directly connected to processing device 140 (as indicated by the double-headed arrow in the dashed line linking terminal 130 and processing device 140) or through network 120.
The PET scanning device 110 may scan an object and/or generate scan data (e.g., projection data) about the object. In this application, the target may also be referred to as a target object, a scanned object, or a detected object, and the above terms may be used interchangeably. In some embodiments, the target may be a living body or organism such as a patient, an animal, etc., or may be an artificial object such as a phantom, etc. The target may also be a specific part of the patient, e.g. an organ and/or tissue. When a target needs to be scanned, it may be placed on the mobile platform 114, with the mobile platform 114 moving along the longitudinal direction of the PET scanning device 110, and into the scanning region 113. Exemplary PET scanning device 110 may be a medical imaging device such as a PET device, a PET-CT device, a PET-MRI device, or the like. The PET scanning device 110 may include a detection assembly 112. After the target enters the scan region 113, the detector assembly 112 may detect radiation events (e.g., electron annihilation events in the target) that occur in the scan region 113. In some embodiments, the detector assembly 112 may include one or more detectors (which may also be referred to herein as detection units). The detectors may be arranged in any suitable shape, such as one or a combination of several of a ring, an arc, a rectangle, an array, etc. For example, the detectors may be arranged along a radial direction of the PET scanning device 110 to form a detector ring. The arrangement of detector assemblies 112 defines a scan region 113.
The network 120 may include any suitable network that may facilitate the exchange of information and/or data with the PET imaging system 100. In some embodiments, one or more components of the PET imaging system 100 (e.g., the PET scanning device 110, the terminal 130, the processing device 140, or the storage device 150) may be used with the radiotracer composition analysis system via the network 120One or more other components of the scenario 100 communicate information and/or data. For example, the processing device 140 may obtain scan data for a plurality of moments from the PET scanning device 110 via the network 120. In some embodiments, the network 120 may be a wired network or a wireless network, or the like, or any combination thereof. Network 120 may be and/or include a public network (e.g., the internet), a private network (e.g., a Local Area Network (LAN), a Wide Area Network (WAN), etc.), a wired network (e.g., an ethernet network), a wireless network (e.g., a Wi-Fi network, a Li-Fi network, etc.), a cellular network (e.g., a Long Term Evolution (LTE) network), a frame relay network, a virtual private network ("VPN"), a satellite network, a telephone network, a router, a hub, a switch, a server computer, and/or any combination thereof. By way of example only, network 120 may include a cable network, a wireline network, a fiber optic network, a telecommunications network, an intranet, a Wireless Local Area Network (WLAN), a Metropolitan Area Network (MAN), a Public Switched Telephone Network (PSTN), bluetooth TM A network, a zigbee (TM) network, a Near Field Communication (NFC) network, an Ultra Wideband (UWB) network, a mobile communication (1G, 2G, 3G, 4G, 5G) network, a narrowband internet of things (NB-IoT), infrared communication, or the like, or any combination thereof. In some embodiments, network 120 may include one or more network access points. For example, the network 120 may include wired and/or wireless network access points, such as base stations and/or internet switching points, through which one or more components of the application scenario 100 of the radio-tracer component analysis system may connect to the network 120 to exchange data and/or information.
The terminal 130 includes a mobile device 130-1, a tablet computer 130-2, a notebook computer 130-3, etc., or any combination thereof. In some embodiments, the terminal 130 may interact with other components in the application scenario 100 of the radiotracer component analysis system over a network. For example, the terminal 130 may send one or more control instructions to the PET scanning device 110 to control the mobile platform 114 to carry a target into the scanning region 113 and to control the detector assembly 112 to receive data. For another example, the terminal 130 may also receive data transmitted by the probe assembly 112. In some embodiments, the terminal 130 may receive information and/or instructions entered by a user (e.g., a user such as a doctor of the application scenario 100 of the radiotracer component analysis system) and send the received information and/or instructions to the PET scanning device 110 or the processing device 140 via the network 120. In some embodiments, terminal 130 may be part of processing device 140. The terminal 130 and the processing device 140 may be integrated as a control means, e.g. a console, of the PET scanning device 110. In some embodiments, the terminal 130 may be omitted.
The processing device 140 may process data and/or information obtained from the PET scanning device 110, the terminal 130, and/or the storage device 150. For example, the processing device 140 may acquire PET scan data. For another example, the processing device 140 may determine the total activity of all radionuclides in the living body corresponding to a plurality of time instants based on the PET scan data, and may also determine the component analysis results of the radiotracer with respect to one or more target radionuclides based on the total activity of the plurality of time instants. In some embodiments, the processing device 140 may be a single server or a group of servers. The server farm may be centralized or distributed. In some embodiments, the processing device 140 may be local or remote. For example, the processing device 140 may access information and/or data stored in or acquired by the PET scanning device 110, the terminal 130, and/or the storage device 150 via the network 120. As another example, processing device 140 may be directly connected to PET scanning device 110 (as indicated by the double-headed arrow in the dashed line connecting processing device 140 and PET scanning device 110 in fig. 1), terminal 130 (as indicated by the double-headed arrow in the dashed line connecting processing device 140 and terminal 130 in fig. 1), and/or storage device 150 to access stored or acquired information and/or data. In some embodiments, the processing device 140 may be implemented on a cloud platform. For example only, the cloud platform may include a private cloud, a public cloud, a hybrid cloud, a community cloud, a distributed cloud, an internal cloud, a multi-layer cloud, or the like, or any combination thereof.
The storage device 150 may store data and/or instructions. In some embodiments, the storage device 150 may store data acquired from the PET scanning device 110, the terminal 130, and/or the processing device 140. For example, the storage device 150 may store motion information of a target object designed in advance by a user (e.g., doctor, imaging technician). In some embodiments, the storage device 150 may store data and/or instructions that the processing device 140 may perform or be used to perform the exemplary methods described herein. For example, the storage device 150 may store instructions for the processing device 140 to perform the methods illustrated in the various flowcharts. In some embodiments, storage device 150 may include mass storage devices, removable storage devices, volatile read-write memory, read-only memory (ROM), and the like, or any combination thereof. Exemplary mass storage may include magnetic disks, optical disks, solid state drives, and the like. Exemplary removable storage may include flash drives, floppy disks, optical disks, memory cards, compact disks, tape, and the like. Exemplary volatile read-write memory can include Random Access Memory (RAM). Exemplary RAM may include Dynamic RAM (DRAM), double data rate synchronous dynamic RAM (ddr sdram), static RAM (SRAM), thyristor RAM (T-RAM), and zero-capacitance RAM (Z-RAM). Exemplary ROMs may include Mask ROM (MROM), programmable ROM (PROM), erasable programmable ROM (PEROM), electrically Erasable Programmable ROM (EEPROM), compact disk ROM (CD-ROM), and digital versatile disk ROM, etc. In some embodiments, storage device 150 may be implemented on a cloud platform. For example only, the cloud platform may include a private cloud, a public cloud, a hybrid cloud, a community cloud, a distributed cloud, an internal cloud, a multi-layer cloud, or the like, or any combination thereof.
In some embodiments, the storage device 150 may be connected to the network 120 to communicate with one or more components of the application scenario 100 of the radiotracer composition analysis system (e.g., the PET scanning device 110, the processing device 140, the terminal 130, etc.). One or more components of the application scenario 100 of the radiotracer component analysis system may access data or instructions stored in the storage device 150 via the network 120. In some embodiments, the storage device 150 may be directly connected to or in communication with one or more components of the application scenario 100 of the radiotracer component analysis system (e.g., the PET scanning device 110, the processing device 140, the terminal 130, etc.). In some embodiments, the storage device 150 may be part of the processing device 140.
In some embodiments, the application scenario 100 of the radiotracer component analysis system may also include one or more power supplies (not shown in fig. 1) connected to one or more components of the application scenario 100 of the radiotracer component analysis system (e.g., the PET scanning device 110, the processing device 140, the terminal 130, the storage device 150, etc.).
Fig. 2 is a block diagram of a radiotracer component analysis system according to some embodiments of the application.
As shown in fig. 2, the radiotracer component analysis system 200 may include an acquisition module 210, an activity determination module 220, and a component analysis module 230.
In some embodiments, the acquisition module 210 may be configured to acquire PET scan data by PET scanning a living being injected with a radiotracer, the PET scan having a scan field of view that covers the entire area of the living being that includes radionuclides that at least approximately covers the entire body of the living being, the radiotracer including one or more target radionuclides.
In some embodiments, activity determination module 220 may be configured to determine a total activity of all radionuclides in the living being corresponding to at least two or not less than a target number of times based on the PET scan data. In some embodiments, the activity determination module 220 may also be configured to: determining a number of true coincidence events of the living radiation corresponding to the at least two or more times not less than the target number based on the PET scan data; based on the number of true coincidence events of the in-vivo radiation corresponding to the at least two or not less than the target number of moments, a total activity of all radionuclides in the living being corresponding to the at least two or not less than the target number of moments is determined. In some embodiments, the activity determination module 220 may also be configured to: correcting the PET scanning data to obtain corrected PET scanning data; based on the corrected PET scan data, a number of true coincidence events of the living radiation corresponding to the at least two or not less than the target number of moments is determined. In some embodiments, the activity determination module 220 may also be configured to: obtaining PET images of the living body corresponding to at least two or more times which are not smaller than the target number based on the PET scanning data; and determining the total activity of all radionuclides in the living body corresponding to the at least two or not less than the target number of moments based on the pixel values of all pixels in the PET image corresponding to the at least two or not less than the target number of moments.
In some embodiments, the component analysis module 230 may be configured to determine a component analysis result of the radiotracer with respect to the one or more target radionuclides based on the total activity at least two times or the total activity at no less than a target number of times, the target number of times being no less than a number of nuclide species of the plurality of target radionuclides. In some embodiments, the component analysis results include: the determination result regarding the other radionuclides except the target radionuclides contained in the radiotracer, or the content of the plurality of target radionuclides in the radiotracer. In some embodiments, the component analysis module 230 may be further configured to determine a theoretical value of activity of the target radionuclide corresponding to at least one time instant, based on the total activity of the at least two time instants and the half-life of the target radionuclide, under the condition that the radionuclide contained in the radiotracer only comprises the target radionuclide; determining a comparison result of a theoretical value of the activity of the target radionuclide corresponding to the at least one moment and the total activity corresponding to the at least one moment; and determining the judging result based on the comparison result. In some embodiments, the component analysis module 230 may also be configured to determine a measure of the half-life of the target radionuclide, based on the total activity of the at least two times, under conditions where the radionuclide contained in the radiotracer includes only the target radionuclide; determining a comparison of the measured value of the half-life of the target radionuclide to the half-life of the target radionuclide; and determining the judging result based on the comparison result. In some embodiments, the component analysis module 230 may be further configured to determine an activity of each of the plurality of target radionuclides corresponding to any one of the target number of times based on the total activity of not less than the target number of times; determining the content of the plurality of target radionuclides based on the activity of each of the plurality of target radionuclides corresponding at any one time.
For more details on the acquisition module 210, the activity determination module 220, and the component analysis module 230, reference may be made to fig. 3, 4, 5, and 6 of the present application and their associated descriptions, which are not repeated here.
It will be appreciated by those skilled in the art that, given the principles of the system, various modules may be combined arbitrarily or a subsystem may be constructed in connection with other modules without departing from such principles. For example, the acquisition module 210, activity determination module 220, and component analysis module 230 disclosed in fig. 2 may be implemented by one module. For another example, each module may share one memory module, or each module may have a respective memory module. Such variations are within the scope of the present application.
Fig. 3 is an exemplary flow chart of a radiotracer composition analysis according to some embodiments of the present description.
In some embodiments, one or more operations in flow 300 may be implemented by processing device 140. For example, the flow 300 may be stored in the storage device 150 in the form of instructions and executed by the processing device 140 for invocation and/or execution.
As shown in fig. 3, the flow 300 may include the following operations.
At step 310, PET scan data is acquired by PET scanning a living body into which a radioactive tracer is injected.
In some embodiments, step 310 may be performed by the acquisition module 210.
The radiotracer is also known as a radiolabel and refers to a compound that is labeled with a radionuclide, wherein labeling with a radionuclide refers to replacing one or more atoms in the compoundAnd is replaced by a radioisotope. Illustratively, the radionuclide may include 3 H、 14 C、 11 C、 18 F、 13 N、 15 O, etc., the radiotracer may include 18 F-FDG、 11 C-MET, etc.
The radionuclide specified to be contained in the radiotracer may be referred to as the target radionuclide. Radiotracers comprising one or more target radionuclides may be prepared by various radiotracer preparation methods.
In some embodiments, the radiotracer comprises a target radionuclide, e.g., a radionuclide 11 C. In some embodiments, a radiotracer that includes one target radionuclide may also include other radionuclides in addition to the target radionuclide due to contamination or the like.
In some embodiments, the radiotracer comprises two or more target radionuclides, e.g., comprises radionuclides 18 F and F 11 C, again e.g. comprising radionuclides 18 F、 11 C and C 13 N。
In some embodiments, a dose of the radiotracer may be injected into a living body, such as into a human body, animal body, plant, or the like. The radiotracer can participate in physiological processes such as substance conversion (e.g., nucleotide conversion), substance metabolism (e.g., glucose metabolism), etc., in a living body, so that the substance (e.g., glucose, protein, nucleic acid, fatty acid, etc.) in the living body can be labeled with a radionuclide (e.g. 11 C、 18 F, etc.) so that the radionuclide can be distributed in the living body or in the tissue, organ in the living body.
The living body may refer to various living objects such as a human body, a plant body, an animal body, an artificial body model, and also such as a living tissue, a living organ, and the like. In the present specification, the living body may be a living body (including a human body, a plant body, an animal body, an artificial body model, a living tissue, and a living organ).
In some embodiments, the radiotracer may be injected into the living body by various means of injection, gas inhalation, oral administration, and the like.
Radionuclides in living organisms emit radiation as the decay proceeds, such as positrons, which can annihilate with electrons of nearby materials to produce photons. In some embodiments, photons generated by emitting positrons as radionuclides decay in living organisms may be detected by PET scanning (positron emission computed tomography) of the living organisms injected with the radiotracer. The data obtained from PET scan may be referred to as PET scan data.
In some embodiments, various PET scanning devices may be employed to perform PET scanning of a living body, such as a PET device, a PET-CT device, a PET-MRI device, and the like.
In some embodiments, when a PET scan is performed on a living body into which a radiotracer is injected, the scan field of view of the PET scan may cover the entire region of the living body containing the radionuclide. Wherein the scan field of view refers to a scan area of the PET scanning device, and the scan field of view covering the living body or an area of the living body may refer to the living body or an area of the living body being located in the scan area, for example, the living body being placed in a scan hole of the PET scanning device.
In some embodiments, the scan field of view of a PET scan of a living subject injected with a radiotracer may at least approximately cover the living subject, such as a human body. The scanning field of view at least approximately covering the living body may include the scanning field of view completely covering the living body (e.g., the living body is placed in a scanning bore of a PET scanning device, the axial length of the PET scanning device is greater than or equal to the length of the living body), or approximately covering the whole body of the living body (e.g., the remainder of the living body is located in the scanning region except for small amounts of parts of the human body, such as hair, nails, etc., that do not include radionuclides).
In some embodiments, the acquired scan data may include PET scan data of the living body corresponding to at least two times or not less than the target number of times.
Step 320, determining a total activity of all radionuclides in the living body corresponding to at least two moments or not less than a target number of moments based on the PET scan data.
In some embodiments, step 320 may be performed by activity determination module 220.
The activity of a radionuclide may refer to the number of radiation particles emitted by the radionuclide, such as the number of positrons emitted. In this specification, the sum of the activities of all radionuclides in a living body may be referred to as the total activity.
In some embodiments, by performing the aforementioned PET scan on the living body into which the radioactive tracer is injected, PET scan data of the living body corresponding to at least two times or not less than the target number of times may be acquired, and based on the PET scan data of the living body corresponding to each time, the total activity of all radionuclides in the living body corresponding to each time may be determined.
Each time a radionuclide emits a positron (or beta particle), two photons, also called a pair of photons, are correspondingly generated. In some embodiments, the PET scanning device employs a coincidence method to measure two photons generated by the positron emission of the radionuclide. Coincidence refers to the selection and counting of coincidence events, i.e., two or more simultaneous events (e.g., the detector of a PET scanning device detects two photons simultaneously), among the output pulses of different detectors. Coincidence events may include true coincidence events, which refers to coincidence events in which one event has an intrinsic causal relationship with another, e.g., both photons are generated by one positron emitted by a radionuclide.
In some embodiments, based on the acquired PET scan data, a true coincidence event number of all radionuclide emissions in the living organism can be determined, such that a total activity of all radionuclides in the living organism can be determined based on the true coincidence event number.
In some embodiments, based on the PET scan data corresponding to a time instant, such as the number of true coincidence events acquired by the PET device corresponding to a time instant, the total activity of all radionuclides in the living being corresponding to the time instant may be determined based on the number of true coincidence events. In some embodiments, the true coincidence event number value may be used as the total activity of all radionuclides in the living body, or further calculation may be performed based on the true coincidence event number value, for example, correction of the true coincidence event number value according to a correction algorithm, etc., and the result of the further calculation is used as the total activity of all radionuclides in the living body.
In some embodiments, due to factors such as radiation scattering, radiation attenuation, inconsistent detection efficiency of the detection unit, etc., the acquired PET scan data is in error with actual radiation data of all living organisms, for example, the number of true coincidence events acquired by the PET device corresponding to a moment is in error with the number of true coincidence events generated by all positrons actually emitted by all radionuclides in the living organisms at the moment. In some embodiments, the acquired PET scan data, such as the number of acquired true coincidence events, may be corrected, such that the errors described above may be corrected, resulting in accurate in vivo radiation data for all radionuclides emitted, such as the number of true coincidence events produced by all positrons emitted by all radionuclides in an accurate living being. In some embodiments, the corrected PET scan data may be referred to as corrected PET scan data.
In some embodiments, the PET scan data may be corrected using one or more of a variety of correction methods, such as attenuation factor correction, occasional coincidence correction, scatter coincidence correction, and the like.
In some embodiments, the PET scan data may also be processed based on a machine learning model, such as a neural network model NN, CNN, RNN, to obtain corrected PET scan data.
In some embodiments, the total activity of all radionuclides in vivo for each time instant may be determined based on corrected PET scan data, such as corrected numbers of true coincidence events.
In some embodiments, PET images may be reconstructed based on the PET scan data to obtain PET images of the living body corresponding to the plurality of time instants.
In some embodiments, the pixel values of each pixel in the PET image may characterize the activity of the radionuclide contained in the spatial volume to which the pixel corresponds. Based on the pixel values of all pixels in the PET image of the living body corresponding to each time instant, the total activity of all radionuclides in the living body corresponding to each time instant can be determined. For example, the pixel values of all pixels in the PET image of the living body corresponding to one time may be summed, and the summed value may be used as the total activity of all radionuclides in the living body corresponding to the time.
Step 330, determining a component analysis result of the radiotracer with respect to the one or more target radionuclides based on the total activity at least two times or not less than a target number of times.
In some embodiments, step 330 may be performed by component analysis module 230.
In some embodiments, for a tracer comprising one target radionuclide, after injection into a living body, a determination regarding the inclusion of other radionuclides in the tracer than the target radionuclide may be determined based on the determined total activity of all radionuclides in the living body corresponding to at least two times.
In some embodiments, the determination as to whether the radiotracer contains a radionuclide other than the target radionuclide may include results of whether the radiotracer contains a radionuclide other than the target radionuclide, an increase or decrease in the radioactivity intensity of the radiotracer caused by the radionuclide other than the target radionuclide contained in the radiotracer, and the like.
More details on determining the result of the determination that the radiotracer contains other radionuclides than the target radionuclide can be found in fig. 4, 5 and their associated description.
In some embodiments, for a tracer comprising a plurality of target radionuclides, after injection into a living body, the content of the plurality of target radionuclides in the tracer may be determined based on a determined total activity of all radionuclides in the living body that corresponds to a number of times not less than the target number, the number of nuclides species of the plurality of target radionuclides.
In some embodiments, the content of the plurality of target radionuclides may include the ratio of the content of the plurality of target radionuclides in the radiotracer, the activity of the plurality of target radionuclides in vivo at various times, and the like.
More details on the determination of the content of the various target radionuclides in the radiotracer can be found in figure 6 and its associated description.
It should be noted that the above description of the process 300 is for purposes of illustration and description only and is not intended to limit the scope of applicability of the application. Various modifications and changes to flow 300 will be apparent to those skilled in the art in light of the teachings of this application. However, such modifications and variations are still within the scope of the present application.
Fig. 4 is an exemplary flow chart of a method of determining the component analysis results of the radiotracer with respect to the one or more target radionuclides, as shown in some embodiments of the present description.
In some embodiments, one or more operations in flow 400 may be implemented by processing device 140. For example, the flow 400 may be stored in the storage device 150 in the form of instructions and executed by the processing device 140 for invocation and/or execution.
In some embodiments, one or more operations in flow 400 may be performed by component analysis module 230. The flow 400 provides an exemplary method for determining the outcome of the determination as to the inclusion of other radionuclides in the radiotracer in addition to the target radionuclide, as described in 330.
As shown in fig. 4, the flow 400 may include the following operations.
Step 410 of determining a theoretical value of the activity of the target radionuclide corresponding to at least one moment in time, based on the total activity of the at least two moments in time and the half-life of the target radionuclide, under the condition that the radionuclide contained in the radio-tracer only comprises the target radionuclide.
As described above, when the radioactive tracer is injected into a living body, the radionuclide in the living body decays with time, and positrons are emitted to annihilate to generate photons. The half-life of a radionuclide is the time required for the radionuclide to decay to half of its original number, and the half-life of a radionuclide known in nature can be determined by various means of interrogation or by experiment.
In some embodiments, for a tracer comprising one target radionuclide, it is unknown whether it is contaminated with other radionuclides, the theoretical value of the activity of the target radionuclide for at least one moment may be determined based on the determined total activity of all radionuclides in the living body and the half-life of the target radionuclide for at least two moments, assuming that the radiotracer is not contaminated, i.e. that the radionuclides comprised by the radiotracer only comprise the target radionuclide.
In some embodiments, the total activity of all radionuclides in the living body corresponding to the determined at least two moments may be identical to the activity of the target radionuclides in the living body corresponding to the at least two moments under the assumption that the radiotracer is not contaminated, i.e. that the radionuclides comprised by the radiotracer only comprise the target radionuclides. An activity equation can be constructed based on the activity of the target radionuclide in the living body and the half-life of the target radionuclide corresponding to at least two moments, wherein the activity of the target radionuclide corresponding to at least one moment is taken as an unknown quantity, the activity of the target radionuclide corresponding to other moments and the half-life of the target radionuclide are taken as known quantities, and the unknown quantity is solved to obtain a theoretical value of the activity of the target radionuclide corresponding to at least one moment.
As an example, the total activity of all radionuclides in vivo corresponding to time A is D A The total activity of all radionuclides in vivo corresponding to time B is D B The theoretical value of the activity of the target radionuclide corresponding to time B is De B The half-life of the target radionuclide is T N Establishing an activity equation as
Figure BDA0003266844980000161
Figure BDA0003266844980000162
Solving an activity equation to obtain a theoretical value De of the activity of the target radionuclide corresponding to the moment B B 。
In some embodiments, theoretical values of the activity of the target radionuclide corresponding to a plurality of moments may be obtained, thereby obtaining a theoretical curve of the activity of the target radionuclide over time.
Step 420, determining a comparison result of the theoretical value of the activity of the target radionuclide corresponding to the at least one moment and the total activity corresponding to the at least one moment.
In some embodiments, comparing the theoretical value of the activity of the target radionuclide corresponding to at least one time with the total activity corresponding to at least one time determined based on the PET scan data may result in a comparison of whether the theoretical value of the activity of the target radionuclide corresponding to at least one time differs from the total activity corresponding to at least one time, a difference between the theoretical value and the total activity, a difference between a curve of the total activity over time determined based on the PET scan data and the theoretical curve, and various relevant data such as similarity of the curve differences.
And 430, determining the judging result based on the comparing result.
In some embodiments, if the comparison indicates that the theoretical value of the activity of the target radionuclide corresponding to at least one time instant differs from the total activity corresponding to at least one time instant, or that the curve of the total activity over time determined based on the PET scan data differs from the theoretical curve, it may be determined whether other radionuclides than the target radionuclide are contained in the radiotracer.
In some embodiments, the result of the increase or decrease in the radioactivity of the radiotracer caused by other radionuclides than the target radionuclides contained in the radiotracer may also be determined based on the difference between the theoretical value and the total activity, various related data of curve differences, and the like. For example, if the total activity at a time instant is greater than the theoretical value of the activity of the target radionuclide corresponding to that time instant, then the increase in the radioactivity of the radiotracer can be determined.
In some embodiments, it may be determined whether other radionuclides than the target radionuclide are contained in the radiotracer based on whether the difference between the theoretical value of the activity of the target radionuclide corresponding to at least one time instant and the total activity corresponding to at least one time instant is greater than a threshold value, or whether the difference between the curve of the total activity over time determined based on PET scan data and the theoretical curve meets a preset condition (e.g., the offset is greater than a threshold value). For example, if the difference is greater than a threshold, or the offset of the curve is greater than a threshold, it is determined whether the radiotracer contains radionuclides other than the target radionuclide. Wherein the threshold may be determined based on actual conditions or experience.
In some embodiments, based on the activities of the target radionuclides in the living body corresponding to the multiple moments, theoretical values of the activities of the target radionuclides corresponding to the multiple moments are obtained, and then the theoretical values are compared with the total activities corresponding to the multiple moments, so that interference of noise data can be reduced or eliminated, and the comparison result is more accurate.
It should be noted that the above description of the process 400 is for purposes of illustration and description only and is not intended to limit the scope of applicability of the application. Various modifications and changes to flow 300 will be apparent to those skilled in the art in light of the teachings of this application. However, such modifications and variations are still within the scope of the present application.
Fig. 5 is an exemplary flow chart of a method of determining the results of a compositional analysis of the radiotracer with respect to one or more target radionuclides, according to some embodiments of the present description.
In some embodiments, one or more operations in flow 500 may be implemented by processing device 140. For example, the flow 500 may be stored in the storage device 150 in the form of instructions and executed by the processing device 140 for invocation and/or execution.
In some embodiments, one or more operations in flow 500 may be performed by component analysis module 230. The flow 500 provides an exemplary method for determining the outcome of the determination as to the inclusion of other radionuclides in the radiotracer in addition to the target radionuclide, as described in 330.
As shown in fig. 5, the flow 500 may include the following operations.
Step 510 of determining a measure of the half-life of the target radionuclide based on the total activity of the at least two moments in time, under the condition that the radionuclide contained in the radiotracer comprises only the target radionuclide.
As described above, when the radioactive tracer is injected into a living body, the radionuclide in the living body decays with time, and positrons are emitted to annihilate to generate photons.
In some embodiments, for a tracer comprising one target radionuclide, whether it is contaminated with other radionuclides is unknown, the total activity of all radionuclides in vivo corresponding to at least two moments in time determined can be equivalent to the activity of the target radionuclide in vivo corresponding to at least two moments in time assuming that the radiotracer is not contaminated, i.e. that the radionuclides comprised by the radiotracer only comprise the target radionuclide. A measure of the half-life of the target radionuclide may be determined based on the activity of the target radionuclide in the living body corresponding to at least two moments.
In some embodiments, an activity equation may be constructed based on the activity of the target radionuclide in the living body and the measured value of the half-life of the target radionuclide corresponding to at least two moments, wherein the measured value of the half-life of the target radionuclide is taken as an unknown quantity, the activity of the target radionuclide in the living body corresponding to at least two moments is taken as a known quantity, and the unknown quantity is solved to obtain the measured value of the half-life of the target radionuclide.
In some embodiments, based on the activity of the target radionuclide in the living body corresponding to a plurality of moments, the measured value of the half-life of the target radionuclide is obtained, so that the interference of noise data can be reduced or eliminated, and the result is more accurate.
Step 520, determining a comparison of the measured value of the half-life of the target radionuclide with the half-life of the target radionuclide.
In some embodiments, comparing the measured half-life of the target radionuclide with the half-life of the target radionuclide may result in a comparison of whether the measured half-life differs from the half-life, the difference between the measured half-life and the half-life, and the like.
And step 530, determining the judging result based on the comparison result.
In some embodiments, if the comparison indicates that the half-life measurement differs from the half-life, it may be determined whether the radiotracer contains radionuclides other than the target radionuclide.
In some embodiments, the result of the increase or decrease in the radioactivity of the radiotracer caused by other radionuclides contained in the radiotracer, other than the target radionuclides, may also be determined based on the difference in half-life measurement and half-life. For example, if the measured half-life is greater than half-life, then the decrease in the radioactivity of the radiotracer can be determined.
In some embodiments, it may be determined whether the radiotracer contains radionuclides other than the target radionuclide based on whether the difference between the measured half-life and the half-life is greater than a threshold. For example, if the difference is greater than a threshold, it is determined whether the radiotracer contains other radionuclides in addition to the target radionuclide. Wherein the threshold may be determined based on actual conditions or experience.
It should be noted that the above description of the process 500 is for purposes of illustration and description only and is not intended to limit the scope of applicability of the application. Various modifications and changes to flow 500 may be made by those skilled in the art in light of the present application. However, such modifications and variations are still within the scope of the present application.
Fig. 6 is an exemplary flow chart of a method of determining the results of a compositional analysis of the radiotracer with respect to one or more target radionuclides, according to some embodiments of the present description.
In some embodiments, one or more operations in flow 600 may be implemented by processing device 140. For example, the flow 600 may be stored in the storage device 150 in the form of instructions and executed by the processing device 140 for invocation and/or execution.
In some embodiments, one or more operations in flow 600 may be performed by component analysis module 230. Flow 600 provides an exemplary method for controlling operation of the plain bearing based on the determination as described in implementation 340.
As shown in fig. 6, the flow 600 may include the following operations.
Step 610, determining an activity of each of the plurality of target radionuclides corresponding to any of the number of times not less than the target number of times based on the total activity not less than the number of times.
As described above, when the radioactive tracer is injected into a living body, the radionuclide in the living body decays with time, and positrons are emitted to annihilate to generate photons.
In some embodiments, for a tracer comprising a plurality of target radionuclides, an activity equation may be constructed based on a total activity of all radionuclides in the living body that is not less than the target number of times, an activity of each of the plurality of target radionuclides in the living body that is not less than the target number of times, and a half-life of the plurality of target radionuclides in the living body that is not less than the target number of times, wherein the activity of each of the plurality of target radionuclides in the living body that is not less than the target number of times is taken as an unknown quantity, the total activity of all radionuclides in the living body that is not less than the target number of times and the half-life of the plurality of target radionuclides in the living body that is not less than the target number of times are taken as known quantities, and the unknown quantity is solved to obtain the activity of each of the plurality of target radionuclides in the living body that is not less than the target number of times.
Step 620, determining the content of the plurality of target radionuclides based on the activity of each of the plurality of target radionuclides corresponding at any one time.
In some embodiments, after determining the activities of the multiple target radionuclides in the living body corresponding to the target number of times, the content of the multiple target radionuclides corresponding to the times can be used as the content of the multiple target radionuclides.
In some embodiments, the activity ratio of the plurality of target radionuclides can also be determined based on the activities of the plurality of target radionuclides in the living body corresponding to the target number of times, and can be used as the content ratio of the plurality of target radionuclides in the radioactive tracer. For example, the ratio of activities of the plurality of target radionuclides can be determined based on the respective activities of the plurality of target radionuclides in the living body corresponding to any one time, and used as the ratio of contents of the plurality of target radionuclides in the radiotracer. The activity proportion of the multiple target radionuclides corresponding to the multiple moments can be determined based on the activities of the multiple target radionuclides in the living body corresponding to the multiple moments, and the average value of the multiple activity proportions is calculated to obtain the content proportion of the multiple target radionuclides in the radioactive tracer.
In some embodiments, based on the respective activities of the multiple target radionuclides in the living body corresponding to the multiple moments, the content conditions of the multiple target radionuclides are obtained, so that the interference of noise data can be reduced or eliminated, and the result is more accurate.
It should be noted that the above description of the process 600 is for purposes of illustration and description only and is not intended to limit the scope of applicability of the application. Various modifications and changes to flow 600 will be apparent to those skilled in the art in light of the teachings of this application. However, such modifications and variations are still within the scope of the present application.
The present description also provides an apparatus comprising a processor for performing the aforementioned radiotracer composition analysis method. The method of radiotracer component analysis may comprise: acquiring PET scan data by PET scanning a living body injected with a radioactive tracer, a scan field of the PET scan covering an entire region of the living body containing radionuclides, the radioactive tracer containing one or more target radionuclides; determining a total activity of all radionuclides in the living body corresponding to at least two or more times not less than the target number based on the PET scan data; determining a component analysis result of the radiotracer with respect to the one or more target radionuclides based on the total activity at least two times or not less than the total activity at the target number of times.
The radiotracer component analysis methods and systems provided by some embodiments of the present description may provide benefits including, but not limited to: (1) The radioactive tracer is injected into a living body, the living body is scanned through PET, scanning data are obtained, the total activity of all radionuclides of the living body is determined based on the scanning data, and the condition of nuclide components in the living body is determined according to the change of the total activity at different moments, so that the radionuclide components of the radioactive tracer can be accurately and conveniently analyzed; (2) By injecting the radioactive tracer into a living body, radiation received by an operator can be reduced based on scanning measurement of the PET scanning equipment, the operation is more convenient, the components of nuclides in the tracer can be determined clinically, and the waste of medicines is reduced. It should be noted that, the advantages that may be generated by different embodiments may be different, and in different embodiments, the advantages that may be generated may be any one or a combination of several of the above, or any other possible advantages that may be obtained.
Having described the basic concepts, it will be apparent to those skilled in the art upon reading this detailed disclosure that the foregoing detailed disclosure is intended to be presented by way of example only and not to be limiting. Various alterations, improvements, and modifications may occur and are intended to be within the skill of the art, though not expressly stated herein. Such alterations, improvements, and modifications are intended to be suggested by this disclosure, and are intended to be within the spirit and scope of the exemplary embodiments of this disclosure.
Furthermore, specific terminology has been used to describe embodiments of the disclosure. For example, the terms "one embodiment," "an embodiment," and/or "some embodiments" mean that a particular feature, structure, or characteristic described in connection with the embodiment is included in at least one embodiment of the present disclosure. Thus, it is emphasized and should be appreciated that two or more references to "an embodiment" or "one embodiment" or "an alternative embodiment" in various portions of this specification are not necessarily all referring to the same embodiment. Furthermore, the particular features, structures, or characteristics may be combined as suitable in one or more embodiments of the disclosure.
Moreover, those of skill in the art will appreciate that aspects of the disclosure may be illustrated and described herein in any of several patentable categories or contexts, including any novel and useful process, machine, manufacture, or composition of matter, or any novel and useful improvement thereof. Furthermore, aspects of the present disclosure may take the form of a computer program product embodied in one or more computer-readable media having computer-readable program code embodied thereon.
The computer readable signal medium may include a propagated data signal with computer readable program code embodied therein (e.g., in baseband or as part of a carrier wave). Such propagated signals may take any of a variety of forms, including electro-magnetic, optical, etc., or any suitable combination thereof. A computer readable signal medium may be any computer readable medium that is not a computer readable storage medium and that can communicate, propagate, or transport a program for execution by or in connection with an instruction execution system, apparatus, or device. Program code embodied on a computer readable signal medium may be transmitted using any appropriate medium, including wireless, wireline, optical fiber cable, RF, etc., or any suitable combination of the foregoing.
Computer program code for carrying out operations for aspects of the present disclosure may be written in any combination of one or more programming languages, including an object oriented programming language such as Java, scala, smalltalk, eiffel, JADE, emerald, C ++, c#, vb.net, python and the like, a conventional procedural programming language such as the "C" programming language, visualBasic, fortran2003, perl, COBOL 2002, PHP, ABAP, dynamic programming languages, such as Python, ruby and Groovy, or other programming languages. The program code may execute entirely on the user's computer, partly on the user's computer, as a stand-alone software package, partly on the user's computer and partly on a remote computer or entirely on the remote computer or server. In the latter scenario, the remote computer may be connected to the user's computer through any type of network, including a Local Area Network (LAN) or a Wide Area Network (WAN), or the connection may be made to an external computer (for example, through the internet using an internet service provider) or provided as a service, such as software as a service (SaaS), in a cloud computing environment.
Furthermore, the recited order of processing elements or sequences, or the use of numbers, letters, or other designations therefore, is not intended to limit the claimed processes and methods to any order, unless may be specified in the claims. While the foregoing disclosure discusses what is presently considered to be various useful embodiments of the disclosure throughout the various examples, it is to be understood that such detail is solely for that purpose and that the appended claims are not limited to the disclosed embodiments, but, on the contrary, are intended to cover modifications and equivalent arrangements that are within the spirit and scope of the disclosed embodiments. For example, while the implementation of the various components described above may be implemented in a hardware device, it may also be implemented as a software-only solution-e.g., installed on an existing server or mobile device.
Similarly, it should be appreciated that in the foregoing description of embodiments of the disclosure, various features are sometimes grouped together in a single embodiment, figure, or description thereof for the purpose of streamlining the disclosure aiding in the understanding of one or more of the various inventive embodiments. This method of disclosure, however, is not to be interpreted as reflecting an intention that the claimed subject matter requires more features than are expressly recited in each claim. Rather, inventive embodiments lie in less than all features of a single foregoing disclosed embodiment.
In some embodiments, numbers expressing quantities or properties used to describe and claim certain embodiments of the present application should be understood as being modified in some instances by the term "about," approximately, "or" substantially. For example, "about," "approximately," or "substantially" may indicate a 20% change in the values described unless otherwise stated. Accordingly, in some embodiments, the numerical parameters set forth in the written description and attached claims are approximations that may vary depending upon the desired properties sought to be obtained by the specific embodiments. In some embodiments, these numerical parameters should be construed in light of the number of reported significant digits and by applying ordinary rounding techniques. Notwithstanding that the numerical ranges and parameters setting forth the broad scope of some embodiments of the application are approximations, the numerical values set forth in the specific examples are reported as precisely as practically possible.
Each patent, patent application publication, and other material, such as an article, book, specification, publication, document, article, etc., in this document is incorporated herein by reference in its entirety for all purposes except for any prosecution history associated with that material, material of that material that is inconsistent or conflicting with that document, or material of that material that may have a limiting effect on the maximum scope of the claims now or later associated with that document. As an example, if there is any inconsistency or conflict between the description, definition, and/or use of a term associated with any of the incorporated materials and the description, definition, and/or use of a term associated with the present document, the description, definition, and/or use of the term in the present document controls.
Finally, it is to be understood that the embodiments of the application disclosed herein are illustrative of the principles of the embodiments of the present application. Other modifications that may be employed may fall within the scope of this application. Thus, by way of example, and not limitation, alternative configurations of embodiments of the present application may be utilized in accordance with the teachings herein. Accordingly, the embodiments of the present application are not limited to as precisely shown and described.

Claims (13)

1. A method of analysis of a radiotracer composition, comprising:
acquiring PET scan data by PET scanning a living body injected with a radioactive tracer, a scan field of the PET scan covering an entire region of the living body containing radionuclides, the radioactive tracer containing one or more target radionuclides;
determining a total activity of all radionuclides in the living body corresponding to at least two or more times not less than a target number based on the PET scan data;
determining a component analysis result of the radiotracer with respect to the one or more target radionuclides based on the total activity at least two times or not less than the total activity at the target number of times, wherein the component analysis result includes a determination result regarding the radiotracer including other radionuclides than the target radionuclides, the target number is not less than the number of species of the plurality of target radionuclides, and the determining a determination result based on the total activity at least two times includes:
Determining a theoretical value of the activity of the target radionuclide corresponding to at least one instant in time, based on the total activity of the at least two instants and the half-life of the target radionuclide, under the condition that the radionuclide contained in the radiotracer only comprises the target radionuclide;
determining a comparison result of a theoretical value of the activity of the target radionuclide corresponding to the at least one moment and the total activity corresponding to the at least one moment;
determining the judging result based on the comparison result; or alternatively, the process may be performed,
determining a measure of the half-life of the target radionuclide based on the total activity of the at least two moments in time under the condition that the radionuclide contained in the radiotracer comprises only the target radionuclide;
determining a comparison of the measured value of the half-life of the target radionuclide to the half-life of the target radionuclide;
and determining the judging result based on the comparison result.
2. The method of claim 1, wherein determining a total activity of all radionuclides in the living being corresponding to at least two or not less than a target number of times based on the PET scan data comprises:
Determining the number of true coincidence events of the living radiation corresponding to the at least two or more times not less than a target number based on the PET scan data;
based on the number of true coincidence events of the living being radiation corresponding to the at least two or not less than the target number of moments, a total activity of all radionuclides in the living being corresponding to the at least two or not less than the target number of moments is determined.
3. The method of claim 2, the determining, based on the PET scan data, a number of true coincidence events of the living radiation corresponding to the at least two or not less than a target number of moments in time comprising:
correcting the PET scanning data to obtain corrected PET scanning data;
based on the corrected PET scan data, a number of true coincidence events of the living radiation corresponding to the at least two or more times not less than a target number is determined.
4. The method of claim 1, wherein determining a total activity of all radionuclides in the living body corresponding to at least two or not less than the target number of times based on the PET scan data comprises:
obtaining PET images of the living body corresponding to at least two or more times which are not smaller than the target number based on the PET scanning data;
And determining the total activity of all radionuclides in the living body corresponding to the at least two or not less than the target number of moments based on the pixel values of all pixels in the PET image corresponding to the at least two or not less than the target number of moments.
5. The method of claim 1, the component analysis results further comprising: the content of the plurality of target radionuclides in the radiotracer.
6. The method of claim 5, said determining the content of the plurality of target radionuclides in the radiotracer based on the total activity at not less than the target number of times comprising:
determining an activity of each of the plurality of target radionuclides corresponding to any one of the target number of times based on the total activity not less than the target number of times;
determining the content of the plurality of target radionuclides based on the activity of each of the plurality of target radionuclides corresponding at any one time.
7. A radiotracer component analysis system, comprising:
an acquisition module for acquiring PET scan data by PET scanning a living body injected with a radioactive tracer, the scan field of view of the PET scan covering all areas of the living body containing radionuclides at least approximately over the whole body of the living body, the radioactive tracer containing one or more target radionuclides;
The activity determining module is used for determining the total activity of all radionuclides in the living body corresponding to at least two or more times which are not less than the target number based on the PET scanning data;
a component analysis module for determining a component analysis result of the radiotracer with respect to the one or more target radionuclides based on the total activity at least two times or not less than the total activity at the target number of times, wherein the component analysis result includes a determination result regarding the radiotracer including other radionuclides than the target radionuclides, the target number is not less than the number of species of the plurality of target radionuclides, and the determining a determination result regarding the radiotracer including other radionuclides than the target radionuclides based on the total activity at least two times includes:
determining a theoretical value of the activity of the target radionuclide corresponding to at least one instant in time, based on the total activity of the at least two instants and the half-life of the target radionuclide, under the condition that the radionuclide contained in the radiotracer only comprises the target radionuclide;
Determining a comparison result of a theoretical value of the activity of the target radionuclide corresponding to the at least one moment and the total activity corresponding to the at least one moment;
determining the judging result based on the comparison result; or alternatively, the process may be performed,
determining a measure of the half-life of the target radionuclide based on the total activity of the at least two moments in time under the condition that the radionuclide contained in the radiotracer comprises only the target radionuclide;
determining a comparison of the measured value of the half-life of the target radionuclide to the half-life of the target radionuclide;
and determining the judging result based on the comparison result.
8. The system of claim 7, the activity determination module further to:
determining a number of true coincidence events of the living radiation corresponding to the at least two or more times not less than the target number based on the PET scan data;
based on the number of true coincidence events of the in-vivo radiation corresponding to the at least two or not less than the target number of moments, a total activity of all radionuclides in the living being corresponding to the at least two or not less than the target number of moments is determined.
9. The system of claim 8, the activity determination module further to:
correcting the PET scanning data to obtain corrected PET scanning data;
based on the corrected PET scan data, a number of true coincidence events of the living radiation corresponding to the at least two or not less than the target number of moments is determined.
10. The system of claim 7, the activity determination module further to:
obtaining PET images of the living body corresponding to at least two or more times which are not smaller than the target number based on the PET scanning data;
and determining the total activity of all radionuclides in the living body corresponding to the at least two or not less than the target number of moments based on the pixel values of all pixels in the PET image corresponding to the at least two or not less than the target number of moments.
11. The system of claim 7, the component analysis results further comprising: the content of the plurality of target radionuclides in the radiotracer.
12. The system of claim 11, the component analysis module further to:
determining an activity of each of the plurality of target radionuclides corresponding to any one of the target number of times based on the total activity not less than the target number of times;
Determining the content of the plurality of target radionuclides based on the activity of each of the plurality of target radionuclides corresponding at any one time.
13. A radiotracer composition analysis apparatus comprising at least one processor and at least one storage device for storing instructions which, when executed by the at least one processor, implement the method of any one of claims 1 to 6.
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