CN113633583B

CN113633583B - Oral care compositions

Info

Publication number: CN113633583B
Application number: CN202111049837.1A
Authority: CN
Inventors: 杨积力; 胡璠; 李立芬; 刘明; 潘志
Original assignee: Guangzhou Stars Pulse Co Ltd
Current assignee: Guangzhou Stars Pulse Co Ltd
Priority date: 2021-09-08
Filing date: 2021-09-08
Publication date: 2024-03-08
Anticipated expiration: 2041-09-08
Also published as: CN113633583A

Abstract

The present application relates to the field of medical technology, and in particular to an oral care composition. The oral care composition comprises: ozonized oil and a hydrophobic modifier; the hydrophobic modifier is hydrophobic association polymer and/or inverse emulsion polymer, and the mass ratio of the ozonized oil to the hydrophobic modifier is (0.1-40): (0.05-5). The ozonized oil is combined with the hydrophobic modifier in the proportion on the basis of the ozonized oil, so that the stability of the ozonized oil can be improved, the ozonized oil is slowly and stably separated out to release ozone in the oral care process, and the oral care effect is stable and controllable, so that the ozonized oil has a good application prospect.

Description

Oral care compositions

Technical Field

The application belongs to the technical field of oral care, and particularly relates to an oral care composition.

Background

Tooth discoloration (Tooth Discoloration) refers to a phenomenon in which the color or shade of teeth changes due to various intrinsic or extrinsic causes; the change in color or luster due to physical causes such as heredity and age, and/or impaired tooth development is called endogenous tooth staining, and tooth staining due to external factors such as smoking, drinking, antibiotics, metals, food coloring, or pigments produced by oral bacteria is called exogenous tooth staining.

Tooth whitening is the process of lightening teeth, which can be achieved by physical stain removal or chemical reaction. The bulk drug in most whitening products is hydrogen peroxide or carbamide peroxide, which is a stable complex that breaks down upon contact with water, releasing hydrogen peroxide. Tooth whitening has become one of the most frequent dental procedures required by the public, and many tooth whitening products have been marketed, such as toothpaste, gel or film household products, and products containing high concentrations of bleaching agents for use under professional supervision. Tooth whitening also creates certain risks such as increased tooth sensitivity and gum irritation, tooth surface roughness and softening, increased potential demineralization, degradation of dental restorations, and unacceptable color changes.

Although hydrogen peroxide is used in most whitening products, the pH of aqueous hydrogen peroxide solutions is typically 3-4.5, which is prone to tooth sensitivity and other oral problems due to the irritation caused by this acidity.

Disclosure of Invention

The invention aims to provide an oral care composition, which aims to solve the technical problem of how to improve the stability of an ozonized oil cavity product.

In order to achieve the purposes of the application, the technical scheme adopted by the application is as follows:

the present application provides an oral care composition comprising: ozonized oil and a hydrophobic modifier; the hydrophobic modifier is a hydrophobic association polymer and/or an inverse emulsion polymer, and the mass ratio of the ozonized oil to the hydrophobic modifier is (0.1-40): (0.05-5).

In one embodiment, the mass ratio of the ozonized oil to the hydrophobic modifier is (20-40): (3-5).

In one embodiment, the viscosity of the oral care composition is not less than 3000mpa.s at 25 ℃ to 27 ℃.

In one embodiment, the ozonized oil has an ozone content of 0.2g/L to 120g/L.

In one embodiment, the ozonated oil is a mixture of ozone solidified into vegetable oil.

In one embodiment, the hydrophobically associating polymer is selected from the group consisting of acrylic acid (esters)/C _10-30 At least one of an alkanol acrylate cross-linked polymer, an acrylic acid (ester) class/stearyl alcohol polyether-20 methyl acrylate cross-linked polymer, a polyacrylate cross-linked polymer-6, polyacrylamide and polyacrylate-13.

In one embodiment, the inverse emulsion polymer is selected from at least one of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, sodium acrylate/sodium acryloyldimethyl taurate copolymer, and ammonium acryloyldimethyl taurate/VP copolymer.

In one embodiment, the oral care composition further comprises: polysaccharide gums for enhancing the viscosity and stability of the oral care composition.

In one embodiment, the polysaccharide gum comprises at least one of gum arabic, xanthan gum, gellan gum, sclerotium gum, pullulan, carob gum, hydroxyethyl cellulose, hydroxypropyl methylcellulose.

In one embodiment, the oral care composition is used to prepare a toothpaste, a dental patch, or an oral gel.

In one embodiment, the oral care composition is for preparing a toothpaste, the oral care composition comprising:

in one embodiment, the oral care composition is used to prepare a dental patch, the oral care composition comprising:

in one embodiment, the oral care composition is for preparing an oral gel, the oral care composition comprising:

the oral care composition comprises ozonized oil and a hydrophobic modifier, wherein the specific hydrophobic modifier is a hydrophobic association polymer and/or an inverse emulsion polymer, and the mass ratio of the ozonized oil to the hydrophobic modifier is (0.1-40): (0.05-5); the ozonized oil is combined with the hydrophobic modifier in the proportion on the basis of the ozonized oil, so that the stability of the ozonized oil can be improved, the ozonized oil is slowly and stably separated out to release ozone in the oral care process, and the oral care effect is stable and controllable, so that the ozonized oil has a good application prospect.

Detailed Description

In order to make the technical problems, technical schemes and beneficial effects to be solved by the present application more clear, the present application is further described in detail below with reference to the embodiments. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the present application.

In the present application, "at least one" means one or more, and "a plurality" means two or more. "at least one of" or the like means any combination of these items, including any combination of single item(s) or plural items(s). The terminology used in the embodiments of the application is for the purpose of describing particular embodiments only and is not intended to be limiting of the application. As used in this application and the appended claims, the singular forms "a," "an," and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise.

The weights of the relevant components mentioned in the embodiments of the present application may refer not only to specific contents of the components, but also to the proportional relationship between the weights of the components, and thus, any ratio of the contents of the relevant components according to the embodiments of the present application may be enlarged or reduced within the scope disclosed in the embodiments of the present application. Specifically, the mass described in the specification of the examples of the present application may be a mass unit known in the chemical industry such as μ g, mg, g, kg.

Embodiments of the present application provide an oral care composition comprising: ozonized oil and a hydrophobic modifier; the hydrophobic modifier is hydrophobic association polymer and/or inverse emulsion polymer, and the mass ratio of the ozonized oil to the hydrophobic modifier is (0.1-40): (0.05-5).

Ozone has the functions of immunostimulating, pain relieving, hypnotizing, detoxification, antibiosis, biological activity, biosynthesis and the like, can treat various diseases, has the characteristics of no wound, no pain, no wound, no discomfort, no side effect and the like, can improve the acceptability and compliance of patients, has lower irritation to ozone relative to hypochlorous acid and hydrogen peroxide, and is more suitable for household use; however, ozone is difficult to store and transport, so that the ozone is difficult to apply to related oral products, and the weak acid ozonized oil is easy to delaminate due to the difficulty in improving the product consistency. The oral care composition provided by the embodiment of the application comprises ozonized oil and a hydrophobic modifier, wherein the specific hydrophobic modifier is a hydrophobic association polymer and/or an inverse emulsion polymer, and the mass ratio of the ozonized oil to the hydrophobic modifier is (0.1-40): (0.05-5). The hydrophobic modifier with the proportion is added on the basis of the ozonized oil, so that the stability of the ozonized oil can be improved, and the ozonized oil slowly and stably separates out and releases ozone in the oral care process, so that the oral care effect is stable and controllable, and the method has a good application prospect.

In the oral care composition, the mass ratio of the ozonized oil to the hydrophobic modifier is (0.1-40): (0.05-5), specifically, 0.1% -40% (e.g., 0.1%, 0.5%, 1%, 5%, 8%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, etc.) of the total product mass of the ozonized oil based on 100% of the total product mass of the oral care composition, and 0.05% -5% (e.g., 0.05%, 0.1%, 0.5%, 1%, 1.5%, 1.8%, 2%, 2.5%, 3%, 3.5%, 4%, 5%, etc.) of the total product mass of the hydrophobic modifier, such that the weight ratio of the ozonized oil to the hydrophobic modifier in the oral care composition is (0.1-40): (0.05-5). For example, in one embodiment, the ozonated oil comprises 0.1% by weight of the total oral care composition, the hydrophobic modifier comprises 0.05% by weight of the total oral care composition, and the mass ratio of ozonated oil to hydrophobic modifier is 0.1:0.05; in one embodiment, the ozonized oil comprises 20% of the total mass of the oral care composition, the hydrophobic modifier comprises 3% of the total mass of the oral care composition, and the mass ratio of the ozonized oil to the hydrophobic modifier is 20:3, a step of; in one embodiment, the ozonated oil comprises 40% of the total mass of the oral care composition, the hydrophobic modifier comprises 5% of the total mass of the oral care composition, and the mass ratio of ozonated oil to hydrophobic modifier is 40:5.

the above-described oral care compositions are useful in the preparation of a variety of oral care products. For example, the oral care composition can be used to prepare a toothpaste, a dental paste, or an oral gel, when used to prepare a toothpaste, the ozonized oil is present in an amount of 0.1% to 20%, the hydrophobic modifier is present in an amount of 0.05% to 3%, and the ozonized oil and the hydrophobic modifier are present in a mass ratio of (0.1 to 20): (0.05-3); when the ozonized oil is used for preparing dental paste or oral gel, the content of the ozonized oil is 0.1-40%, the content of the hydrophobic modifier is 0.05-5%, and the mass ratio of the ozonized oil to the hydrophobic modifier is (0.1-40): (0.05-5). Because the dental tape and the oral gel have higher viscosity and longer use time in the oral cavity, the content of the ozonized oil and the content of the hydrophobic modifier can be appropriately increased to further prolong the effect of oral care.

In one embodiment, the mass ratio of the ozonized oil to the hydrophobic modifier is (20-40): (3-5). In the body, the content of ozonized oil is 20-40% and the content of hydrophobic modifier is 3-5% based on 100% of the total mass of the oral care composition, wherein the ozonized oil and the hydrophobic modifier are mixed according to the mass ratio of (20-40): (3-5); this may further enhance the oral care effect.

In one embodiment, the ozonated oil in the oral care composition is a mixture of ozone solidified into vegetable oil, such that the ozone is present as a stable oil-soluble ozone active. Wherein the vegetable oil is selected from at least one of avocado oil, sweet almond oil, rice bran oil, wheat germ oil, palm oil, coconut oil, olive oil, argan oil, sunflower seed oil, raspberry oil, dog rose fruit oil, safflower oil, soybean oil, rapeseed oil, linseed oil, corn oil, peanut oil, cranberry seed oil, macadamia nut oil, sea buckthorn oil, camellia oil, shea butter and white pond flower seed oil. Further, the vegetable oil is a liquid or solid oil of vegetable origin containing 0 to 20wt% of saturated fatty acid, specifically, the saturated fatty acid content is 5 to 15wt%, or 10 to 15wt%. The embodiment of the application uses the relatively stable oil-soluble ozone active substance, namely the ozonized oil to replace ozone, and when the ozonized oil is added as a tooth whitening component, the ozonized oil has the additional functions of inhibiting bacteria by ozone, preventing decayed teeth, removing bad breath and the like, and simultaneously has the repairing effect of related unsaturated grease on oral mucosa, so that the ozonized oil has better oral care effect compared with tooth bleaching agents such as peroxide and the like. In addition, the oral care composition containing the ozonized oil can realize the pH value of the product at 4.5-7.0, ensure the high stability of the ozonized oil under the weak acid condition, reasonably prevent the irritation and corrosiveness of acidic components to oral mucosa and teeth, and simultaneously compound with hydrophobic association polymer and/or inverse emulsion polymer, so that the composition system is better stable and is not easy to delaminate, and the problem of the formula stability of functional oral products such as toothpaste, dental paste and oral gel of the ozonized oil is better solved.

Further, in the ozonized oil, the ozone content is 0.2g/L to 120g/L, namely, the mass of the ozone absorbed by each liter of vegetable oil is 0.2g to 120g, and specifically, the ozone can be 1g to 100g/L, or 10g to 80g/L, or 30g to 60g/L. Ozone in the above content range can play a good tooth whitening effect.

In one embodiment, the hydrophobic modifier is a hydrophobically associating polymer and/or an inverse emulsion polymer; wherein, the hydrophobic association polymer refers to a polymer which is subjected to hydrophobic association modification on a polymer hydrophilic macromolecule, and has tackifying and temperature resisting capabilities; the inverse emulsion polymer is a monomer aqueous solution prepared from water-soluble monomers, forms water-in-oil emulsion with an organic phase under the action of an oil-soluble surfactant, and then forms a water-in-oil polymer through the polymerization reaction initiated by an oil-soluble initiator, so that the viscosity and the static force of the system can be further increased. Further, the hydrophobically associating polymer is selected from acrylic acid (esters)/C _10-30 At least one of an alkanol acrylate cross-linked polymer, an acrylic acid (ester) class/stearyl alcohol polyether-20 methyl acrylate cross-linked polymer, a polyacrylate cross-linked polymer-6, polyacrylamide and polyacrylate-13. The inverse emulsion polymer is selected from hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, sodium acrylate/acryloyldi-sodiumAt least one of sodium methyl taurate copolymer and ammonium acryloyldimethyl taurate/VP copolymer. By means of the above-mentioned kind of hydrophobic modifier, the consistency in the oral care composition is improved and the system is more stable.

In one embodiment, the viscosity of the oral care composition is not less than 3000mpa.s at 25-27 ℃. Further, the viscosity change of the ozonized oil cavity nursing product prepared by the oral care composition at 50 ℃ for 1 month is small, and the oral care composition has good stability.

In one embodiment, the oral care composition further comprises: polysaccharide gums for enhancing the viscosity and stability of the oral care composition. The polysaccharide gum belongs to a gum polymer, and can be used for enhancing the viscosity and stability of a composition formula. Further, the polysaccharide gum comprises at least one of gum arabic, xanthan gum, gellan gum, sclerotium gum, pullulan, carob gum, hydroxyethyl cellulose, hydroxypropyl methylcellulose. Polysaccharide gums of the above-described type may well achieve the viscosity and stability enhancing effects of the oral care compositions of the embodiments herein.

The oral care compositions of the embodiments of the present application are useful for preparing toothpastes, tooth pastes or oral gels. The oral care product prepared by the oral care composition is convenient to use, high in practicality and high in market value.

In one embodiment, an oral care composition for preparing a toothpaste, the oral care composition comprising: 25% -30% of wetting agent; 1% -5% of foam stabilizer; 20% -30% of friction agent; 1% -10% of a surfactant; 0.5 to 1 percent of pH regulator; ozonized oil 1-20%; 0.1 to 3 percent of hydrophobic modifier; 0.2 to 0.8 percent of preservative; 8 to 12 percent of water solvent. The toothpaste prepared by the oral care composition in the proportion range can ensure that ozonized oil in the toothpaste has good stability, and the oral care effect is stable and controllable when the toothpaste is used. The specific types of ozonized oil and hydrophobic modifier therein are set forth in detail above.

Wherein the wetting agent can be one or more of sorbitol, glycerol, xylitol, etc., the foam stabilizer can be polyethylene glycol such as PEG-400, the friction agent can be silicon dioxide, the pH regulator can be alkali salt such as sodium hydroxide, potassium hydroxide, etc., and the preservative can be phenoxyethanol; surfactants which still have a foaming function under weakly acidic conditions may be used to enhance the foaming properties of the toothpaste, such as one or more of fatty alcohol sulfate, fatty alcohol polyether sulfate, fatty acyl glutamate, alkyl glucosides, betaines, fatty acyl taurates, fatty acyl methyl taurates; specifically, the surfactant may be one or a combination of several of sodium lauryl sulfate, sodium laureth sulfate, sodium cocoyl glutamate, disodium cocoyl glutamate, sodium lauroyl glutamate, disodium lauroyl glutamate, decyl glucoside, lauryl glucoside, cocoyl glucoside, cocobetaine, cocoamidopropyl betaine, lauryl hydroxysulfobetaine, sodium lauroyl taurate, sodium cocoyl methyl taurate. Wetting agents, foam stabilizers, abrasives, surfactants, pH adjusters and preservatives of the above-mentioned kind are readily available on the market and perform their respective functions well so that they can be mixed with ozonized oil and hydrophobic modifier to make toothpaste.

Further, the oral care composition for preparing a toothpaste comprises: 28% of a wetting agent; 3% of foam stabilizer; 25% of a friction agent; 10% of a surfactant; 0.8% of pH regulator; ozonized oil 20%; 3% of a hydrophobic modifier; 0.5% of preservative; 9.7% of water solvent.

In one embodiment, an oral care composition is used to prepare a dental patch, the oral care composition comprising: 6-10% of film forming agent; 0.1 to 0.5 percent of emollient; 0.5 to 2 percent of adhesive; 5% -10% of wetting agent; 1% -3% of pH regulator; 1 to 40 percent of ozonized oil; 0.1 to 5 percent of hydrophobic modifier; 0.1 to 0.5 percent of preservative; 30-40% of water solvent. The ozonized oil in the dental paste prepared by the oral care composition in the proportion range has good stability, and the oral care effect is stable and controllable when the dental paste is used. The specific types of ozonized oil and hydrophobic modifier therein are set forth in detail above.

The film forming agent can be polymer for additionally enhancing the viscosity and stability of the formula, such as polyvinylpyrrolidone, and glycogelatin polymer: gum arabic, xanthan gum, gellan gum, sclerotium gum, pullulan, carob gum, hydroxyethyl cellulose, hydroxypropyl methylcellulose, or a combination of several thereof. The emollient may be lysolecithin, the adhesive may be PEG-400, which has both tackiness and wettability, the wetting agent may be one or more of sorbitol, glycerol, xylitol, etc., the pH regulator may be alkali salt such as sodium hydroxide, potassium hydroxide, etc., and the preservative may be phenoxyethanol. Film formers, emollients, adhesives, humectants, pH adjusters and preservatives of the above-mentioned kind are readily available on the market and perform their respective functions well and can be mixed with ozonized oil and a hydrophobic modifier to make dental patches.

Further, the oral care composition for preparing a dental patch comprises: 8.8% of film forming agent; 0.2% of an emollient; 1.5% of adhesive; 8% of a wetting agent; pH regulator 2%; 40% of ozonized oil; 4% of a hydrophobic modifier; 0.3% of preservative; 35.2% of water solvent.

In one embodiment, an oral care composition is used to prepare an oral gel, the oral care composition comprising: 6-10% of film forming agent; 2% -8% of sweetener; 0.1 to 0.5 percent of wetting agent; 1% -4% of pH regulator; 1 to 40 percent of ozonized oil; 0.1 to 5 percent of hydrophobic modifier; 30% -50% of excipient. The oral gel prepared by the oral care composition in the proportion range can ensure that ozonized oil in the oral gel has good stability, and the oral care effect is stable and controllable when the oral gel is used. The specific types of ozonized oil and hydrophobic modifier therein are set forth in detail above.

The film forming agent can be polyvinylpyrrolidone and a glycogelatin polymer: gum arabic, xanthan gum, gellan gum, sclerotium gum, pullulan, carob gum, hydroxyethyl cellulose, hydroxypropyl methylcellulose, or a combination of several thereof. The sweetener can be sucralose, the wetting agent can be one or more of sorbitol, glycerol, xylitol and the like, the pH regulator can be alkali salt such as sodium hydroxide, potassium hydroxide and the like, and the excipient can be polyvinyl alcohol. Film formers, sweeteners, wetting agents, pH adjusters and excipients of the above-mentioned kind are readily available on the market and perform their respective functions well so that they can be mixed with the ozonized oil and the hydrophobic modifier to make an oral gel.

Further, the oral care composition for preparing an oral gel comprises: 8% of film forming agent; 5% of sweetener; 0.2% of wetting agent; pH adjustor 2.5%; 40% of ozonized oil; 5% of a hydrophobic modifier; 39.3% of excipient.

Ozonized oil products such as toothpastes, tooth pastes or oral gels, as embodied herein, may be prepared in a conventional manner. The functional oral product containing the ozonized oil has the advantages that the stability of the ozonized oil is high, the process of the ozonized oil whitening is a process of slowly separating out and releasing ozone, the ozone is an unstable gas, the half life period of the ozone is only 16-25 minutes, and the ozone can be slowly reduced into oxygen at normal temperature (25-27 ℃). Therefore, the product is stable and controllable, very safe and relatively environment-friendly. In addition, the pH value of the functional oral product containing the ozonized oil is controlled to be 4.5-6.5, so that the high stability of the ozonized oil under the acidic condition can be ensured, the irritation and corrosiveness of acidic components to oral mucosa and teeth can be reasonably prevented, and the stable addition of the ozonized oil in products in various forms can be realized by selecting the hydrophobic modifier.

Therefore, the functional oral product containing the ozonized oil is suitable for popularization in various occasions and crowds, and has more comprehensive efficacy and development potential in clinical experiments. The novel functional component of the ozonized oil can comprehensively care the oral health and realize the effects of one component with multiple components. In addition, the functional oral product containing the ozonized oil can be used as the coating matched with blue light, red light, LED and other tooth whitening instruments, and related non-efficacy added coatings can accelerate the generation of free radicals to realize the combination of the instruments and the products, and ozone released in the process can effectively avoid potential damage of mucous membranes caused by illumination.

The following description is made with reference to specific embodiments.

Example 1

A toothpaste, the formula of which is as follows:

TABLE 1

Example 2

A dental tape comprising the following formulation:

TABLE 2

Raw materials	Action	Content (%)
			Polyvinylpyrrolidone	Film forming agent	8
Xanthan gum	Film forming agent	0.2
			Sclerotium gum	Film forming agent	0.2
Pullulan sugar	Film forming agent	0.4
			Lysolecithin	Emollient(s)	0.2
PEG-400	Adhesive and wetting agent	1.5
			Polyacrylate crosslinked Polymer-6	Hydrophobically associating polymers	4
Sodium hydroxide	PH regulator	2
			Ozonized sunflower seed oil	Functional component	40
Glycerol	Wetting agent	5
			Xylitol	Wetting agent	3
Phenoxyethanol	Preservative agent	0.3
			Deionized water	Solvent(s)	35.2

Example 3

An oral gel comprising the following formulation:

TABLE 3 Table 3

Comparative example 1

A toothpaste, the formula of which is as follows:

TABLE 4 Table 4

Comparative example 2

A dental tape comprising the following formulation:

TABLE 5

Raw materials	Action	Content (%)
			Polyvinylpyrrolidone	Film forming agent	8
Xanthan gum	Film forming agent	0.2
			Sclerotium gum	Film forming agent	0.2
Pullulan sugar	Film forming agent	0.4
			Lysolecithin	Emollient(s)	0.2
PEG-400	Adhesive and wetting agent	1.5
			Carbomer (carbomer)	Non-hydrophobically associating polymers	4
Sodium hydroxide	PH regulator	2
			Ozonized sunflower seed oil	Functional component	40
Glycerol	Wetting agent	5
			Xylitol	Wetting agent	3
Phenoxyethanol	Preservative agent	0.3
			Deionized water	Solvent(s)	35.2

Comparative example 3

An oral gel comprising the following formulation:

TABLE 6

Performance testing

The oral care products prepared in examples 1-3 and comparative examples 1-3 were subjected to stability testing at 50 ℃ for 1 month (M), and the test results are summarized in the following table:

TABLE 7

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The above data indicate that: the product of the embodiment of the application has better stability due to the addition of the special hydrophobic modifier.

The foregoing description of the preferred embodiments of the present application is not intended to be limiting, but is intended to cover any and all modifications, equivalents, and alternatives falling within the spirit and principles of the present application.

Claims

1. A dental patch, the patch comprising:

6% -10% of film forming agent;

0.1% -0.5% of an emollient;

0.5% -2% of adhesive;

5% -10% of wetting agent;

1% -3% of a pH regulator;

1% -40% of ozonized oil;

0.1% -5% of a hydrophobic modifier;

0.1% -0.5% of preservative;

30% -40% of a water solvent;

the hydrophobic modifier is a hydrophobic association polymer or a mixture of hydrophobic association polymer and inverse emulsion polymer, and the hydrophobic association polymer is selected from acrylic acid (ester)/C _10-30 At least one of alkanol acrylate cross-linked polymer, acrylic acid (ester) or stearyl alcohol polyether-20 methacrylate cross-linked polymer and polyacrylate cross-linked polymer-6, wherein the inverse emulsion polymer is at least one of hydroxyethyl acrylate or sodium acryloyldimethyl taurate copolymer, sodium acrylate or sodium acryloyldimethyl taurate copolymer and ammonium acryloyldimethyl taurate/VP copolymer;

the mass ratio of the ozonized oil to the hydrophobic modifier is (20-40): (3-5), wherein the ozone content of the ozonized oil is 0.2 g/L-120 g/L.

2. The dental patch of claim 1, wherein the viscosity of the dental patch is not less than 3000mpa.s at 25 ℃ to 27 ℃.

3. The dental patch of claim 1 wherein the ozonated oil is a mixture of ozone solidified into vegetable oil.

4. A dental patch according to any one of claims 1 to 3, wherein the film forming agent is selected from at least one of polyvinylpyrrolidone and gum arabic, xanthan gum, gellan gum, sclerotium gum, pullulan, carob gum, hydroxyethyl cellulose and hydroxypropyl methylcellulose; and/or the number of the groups of groups,

the emollient is selected from lysolecithin; and/or the number of the groups of groups,

the adhesive is selected from polyethylene glycol; and/or the number of the groups of groups,

the wetting agent is selected from sorbitol, glycerol and xylitol; and/or the number of the groups of groups,

the pH regulator is selected from alkali; and/or the number of the groups of groups,

the preservative is selected from phenoxyethanol.