CN113616941A - 4 treatment room BNCT cancer treatment device based on strong flow cyclotron - Google Patents
4 treatment room BNCT cancer treatment device based on strong flow cyclotron Download PDFInfo
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Abstract
The invention discloses a BNCT cancer treatment device of a 4 treatment room based on a high-current cyclotron, which comprises a cyclotron for generating negative hydrogen ions, a stripping target leading-out structure for stripping the negative hydrogen ions into protons, a beam transmission line for sending beam to the treatment room, and a neutron target system for uniformly capturing proton beams; the stripping target leading-out structure is provided with 2 stripping targets which are symmetrically arranged on the cyclotron by 180 degrees; the number of the beam transmission lines is 2, one end of each beam transmission line is led out from the stripping target, and the other end of each beam transmission line is connected with the neutron target system; the number of the neutron target systems and the number of the treatment chambers are respectively 4, each neutron target system is connected with one treatment chamber, each beam transmission line corresponds to 2 neutron target systems and 2 treatment chambers, and the beam transmission lines are beam lines with radioisotope production target mechanisms. The hardware cost is saved by more than 1000 ten thousand yuan.
Description
Technical Field
The invention belongs to the technical field of medical cancer treatment cyclotrons, and particularly relates to a BNCT (bayonet nut connector) cancer treatment device with a 4 treatment room based on a strong-flow cyclotron.
Background
BNCT (boron neutron capture) cancer therapy device is a new cancer therapy mode developed in recent years, is one of the international leading anticancer therapy technologies, and the principle thereof is to use non-radioactive boron isotope (boron-10) as tumor localization drug and neutron capture agent.
The diagnosis and treatment of cancer are divided into two stages, the first stage before treatment, in the first stage, the medicine for cancer diagnosis is injected into human body for cancer diagnosis before treatment; the treatment process is taken as the second stage, in the second stage, the medicine for treating the cancer is injected into a human body until the medicine reaches a certain concentration at the tumor, the tumor is irradiated by utilizing a neutron beam generated by targeting with an accelerator, the neutron beam and a boron isotope (boron-10) carry out nuclear reaction to generate radioactive particles, the cancer cells are accurately destroyed in the cancer cells, and normal tissues are not accidentally injured. The second stage is also called BNCT (boron neutron capture) cancer treatment stage, and the second stage is subdivided into two sub-stages, wherein the first sub-stage is used for injecting boron-containing medicine into a patient body to carry out tumor localization, and the second sub-stage is used for irradiating the tumor by utilizing neutron beams generated by accelerator targeting when the medicine reaches a certain concentration at the tumor part.
Currently, commonly used radioisotope drugs used in the first stage and the first sub-stage of the second stage are18F-FDG、18F-BPA, and18F-BSH, all produced by target-making with accelerators18Production of F radioisotopes by synthesis chambers18F-FDG、18F-BPA and18F-BSH. The medicine is prepared from18F-FDG is injected into a human body for cancer diagnosis before treatment; the medicine is prepared from18F-BPA and18F-BSH is injected into a human body, and the concentration information of the medicine in the tumor of the human body is obtained along with the time (the concentration of the medicine in the human body is different at different times), so that the treatment is carried out within the time when the medicine reaches the optimal concentration. The method specifically comprises the following steps: the PET/CT device is used for real-time human body imaging to obtain the distribution and concentration information of the medicine in the human body tumor, thereby providing reliable basis for selecting the optimal time of clinical treatment.
Currently, international BNCT cancer therapy apparatus based on small cyclotron is only developed successfully by 2 treatment room equipments based on 30MeV cyclotron of japan sumitomo, as shown in fig. 6, the implementation method is: the beam current is led out from 1 stripping target of the accelerator and is divided into two treatment rooms for use through a switch magnet. The problems of the method are that: the BNCT cancer treatment device can only irradiate the tumor by utilizing the neutron beam generated by the target shooting of the accelerator, but can not irradiate the tumor and simultaneously produce the medicines for diagnosing and positioning the tumor18F-FDG、18F-BPA and18the F-BSH equipment needs another special accelerator for producing the medicine, and the cost of BNCT cancer treatment equipment is increased because the equipment cannot be used for two purposes. Another problem with this approach is that: although there are 2 treatment rooms, the situation of insufficient supply and demand of the treatment equipment still occurs. With the advancement of technology, the treatment time is shorter and shorter, but the availability of the equipment cannot be increased: because the radiation dose deposited in the environment is relatively large and cannot be dispersed immediately after the patient is treated in the current treatment room, the radiation dose must be deposited relatively largeLet the device wait a period of time before entering the next treatment, so that, although 2 treatment rooms, 2 treatment rooms are not sufficient.
In addition to the above-mentioned inability to achieve "one device for multiple purposes", the difficulty of the prior art is to overcome the defect that 2 treatment rooms cannot meet the requirements and to achieve a BNCT comprehensive cancer diagnosis and treatment device with more than 2 treatment rooms (e.g. 4 treatment rooms) for multiple treatment rooms: simplifying the structure of the device and reducing the cost. First, the prior art peeling targets have a complex structure and high manufacturing costs. Patent No. 202011297102.6, patent name: a high-precision electromagnetic combination measuring method and a negative hydrogen cyclotron based on the method are disclosed, wherein a plurality of leading-out channels are realized by adopting double stripping targets which are symmetrically distributed at 180 degrees so as to improve the utilization rate of the cyclotron. However, this peeling target works in a telescopic manner, and in the working state, the peeling target is extended forward to allow the peeling film to reach the peeling position, and in the non-working state, the peeling target is retracted backward to allow the peeling film to be separated from the peeling position. Because the push-pull type stripping target is a long rod, the stripping target rod needs to extend into a vacuum chamber of an accelerator from outside to inside to complete telescopic action, holes need to be formed in a magnet yoke of the accelerator, and because a magnetic field is closed, the uniformity of the original magnetic field can be damaged after the magnet yoke is punched, so that the acceleration of particles is influenced. In order to compensate for the damaged magnetic field, a series of measures such as magnet inserts and other methods are adopted to cause the loss caused by punching, and the whole army is really driven by the pulling of one round. Secondly, the beam transmission line in the prior art has a complex structure and high manufacturing cost. For example, in a 2 treatment room apparatus based on a 30MeV cyclotron of japan sumitomo, a beam transmission line adopts a combination method including a plurality of quadrupole lenses for controlling the shape of divergence or contraction of a beam, since the diameter of a beam extracted from an accelerator is generally 1 cm and the diameter of a neutron target is 8 cm, a combination of the plurality of quadrupole lenses is used to perform a function of expanding a beam cross-sectional area in order to expand a beam of 1 cm to 8 cm. The manufacturing cost of the quadrupole lens is high, and if the treatment room 2 is improved to the treatment room 4, the manufacturing cost of the beam transmission line is doubled, so that the cost performance is reduced.
Disclosure of Invention
The invention aims to solve the problems in the prior art and provides a BNCT (bayonet nut connector) cancer treatment device with a 4 treatment room based on a high-current cyclotron, and the first purpose is to skillfully utilize the energy range characteristic of a 14MeV high-current cyclotron and add a beam line18F and other radioactive isotopes production target realizes production18F-FDG (for cancer diagnostic drugs), and18F-BPA (a drug for cancer therapy),18The purpose of a multipurpose drug for cancer diagnosis and treatment such as F-BSH (drug for cancer treatment); the second purpose is to solve the problems that the BNCT treatment device based on the single stripping target in the prior art is low in utilization rate and cannot meet the multi-flow strong distribution requirement at the same time; the third purpose is to solve the problems of complex structure of the stripping target and the beam transmission line and high manufacturing cost of the BNCT cancer treatment device for realizing the 4 treatment rooms.
In order to solve the technical problem, the invention provides the following technical scheme:
a4 treatment room BNCT cancer treatment device based on a strong flow cyclotron is characterized in that: the device comprises a cyclotron 1 for generating negative hydrogen ions, a stripping target leading-out structure 5 for stripping the negative hydrogen ions into protons, a beam transmission line 2 for sending beam to a treatment room 6, and a neutron target system 3 for uniformly capturing proton beams; the stripping target leading-out structure 5 is provided with 2 stripping targets which are symmetrically arranged on the cyclotron 1 at 180 degrees; the beam transmission lines 2 are 2, one end of each beam transmission line is led out from the stripping target, and the other end of each beam transmission line is connected with the neutron target system 3; the number of the neutron target systems 3 and the number of the treatment chambers 6 are respectively 4, each neutron target system 3 is connected with one treatment chamber, and each beam transmission line 2 corresponds to 2 neutron target systems 3 and 2 treatment chambers;
the method is characterized in that: the stripping target leading-out structure 5 can rotate by an angle, and the length of a stripping film can be adjusted; the tail end of the beam transmission line 2 is provided with a rotating magnet 2-5, and the beam is scanned on the neutron target in a spiral line type or a circular shape through the rotating magnet 2-4, so that the beam is uniformly distributed on the target.
Moreover, the beam transmission line 2 is a mechanism 2 with a radioactive isotope production target-6 beam streamlines, the radioisotope production target mechanism 2-6 producing18F radioactive isotope and transferring into the synthesis chamber18F-BPA、18F-BSH、18Synthesizing F-FDG; the beam transmission line 2 with the radioisotope production target mechanism 2-6 comprises two beam pipelines 2-1 which are symmetrically arranged at 180 degrees, and each beam pipeline 2-1) comprises 1 trunk line and 2 branches, a pair of X-Y guide magnets 2-2, a pair of four-stage lens groups 2-3, an extraction switch magnet 2-4, two rotating magnets 2-5 extracted from the extraction switch magnet 2-4, and a radioisotope production target mechanism 2-6 extracted from a middle pore channel of the extraction switch magnet 2-4; the beam led out by the cyclotron 1 is transmitted through a beam pipeline 2-1; the pair of X-Y guiding magnets 2-2 realizes the control of the transmission direction of the beam flow; the pair of four-stage lens groups 2-3 realizes the control of beam envelope; the leading-out switch magnet 2-4 is used for the radioisotope production target mechanism 2-6 in a time-sharing mode, and respectively transmits the beam current to the two neutron target systems in a time-sharing mode, spiral line type or circular scanning of the beam current on the neutron target is achieved through the rotating magnet 2-5, and finally uniform distribution of the beam current on the target is achieved.
Furthermore, the radioisotope production target mechanism 2-6 includes a radioisotope production target 2-6-1 and a rabbit running line 2-6-2, the radioisotope production target 2-6-1 being produced18F radioactive isotope and transferring into the synthesis chamber through rabbit running pipeline 2-6-218F-BPA、18F-BSH、18Synthesizing F-FDG; when the treatment room does not work, the beam current led out from the cyclotron 1 is transmitted to a radioactive isotope production target 2-6-1 through a transmission line 2, and the radioactive isotope production target is produced by target shooting18A radioactive isotope of F.
Moreover, the stripping target leading-out structure 5 is provided with a stripping film 5-1 and a set of vertical driving devices 5-2 on one side; the angle of rotation of the peeling and leading-out structure 5 is as follows: when the stripping target is in a non-working state, the plane of the stripping film is parallel to the beam direction by 180 degrees, and when the stripping target is in a working state, the stripping target rotates by 90 degrees, so that the plane of the stripping film is perpendicular to the beam direction by 90 degrees.
Further, the release film is adjustable in length in that: the length of the stripping film is adjusted according to different requirements of the treatment chambers symmetrically arranged at 180 degrees on beam current intensity, wherein the length of the stripping film at one end requiring strong current is relatively long, and the length of the stripping film at one end requiring small current is relatively short.
Advantageous effects of the invention
1. The invention skillfully utilizes the energy range characteristic of the 14MeV strong-current cyclotron and adds the energy range characteristic on a beam line18F and other radioactive isotope medicine production targets achieve the purposes of treating and simultaneously producing multipurpose medicines by using the same accelerator. According to the method in the prior art, two single devices are adopted for respectively preparing medicines and treating medicines, each device occupies at least 1000 ten thousand yuan, two sets of sites and two sets of operation and maintenance personnel are occupied, the two sets of devices, one site and one set of operation and maintenance personnel are combined into one set of device, one site and one set of operation and maintenance personnel, the cost is greatly reduced, and only the hardware cost is saved by more than 1000 thousand yuan.
2. The invention adopts a 10-20MeV strong current cyclotron, 2 beam transmission lines, 4 neutron target systems and 2 radioisotope production target mechanisms, realizes the capability of 4 cancer diagnosis and treatment devices in a treatment room, and obtains the outstanding effects of complete functions and cost reduction:
firstly, the production of the radioactive drug used for the treatment process can be carried out in the treatment interval by adopting the production mode of the bidirectional radioactive isotope production target mechanism, so that the multifunctional radioactive isotope production device achieves multiple purposes, and the functions of two accelerators are completed by one accelerator, thereby greatly reducing the cost.
Second, through the two target techniques of peeling off with cyclotron rotatable angle, 2 leading-out direction techniques of a beam transmission line drive, realize with rotatory magnet that the beam evenly distributed technology carries out organic combination on the neutron target, greatly reduced the cost:
thirdly, 2 symmetrical stripping target structures are adopted, and with the increase of beam current intensity of the accelerator in the future, beam current can be simultaneously provided for beam current transmission lines in two directions by using the double stripping target structures, so that the capability of simultaneously supplying and treating beams for two treatment rooms by one accelerator is realized, and the utilization rate of the accelerator is improved;
fourthly, the structure of the pull-plug type stripping target with a rotatable angle and the stripping film with a replaceable length are adopted, so that the structural design of the stripping target is greatly simplified, and the cost is reduced;
fifthly, 2 stripping films are arranged on each stripping target, so that the running time is prolonged;
sixth: one transmission line is adopted to share the X-Y guide magnet and the pair of four-stage lenses on the beam transmission line, and only two branches are respectively provided with one rotating magnet, so that one beam transmission line drives 2 leading-out directions, and the cost of the transmission line is greatly reduced;
seventh, the beam current is rotated circularly or spirally by adopting the rotating magnet, so that the beam current is uniformly distributed on the neutron target, a combination mode that a plurality of quadrupole lenses are adopted to uniformly distribute the beam current on the neutron target is replaced, the cost is reduced, the design pressure for cooling the neutron target is reduced, and the neutron yield is more stable;
and eighthly, a combination mode of 4 treatment chambers is adopted, so that the working time of a single neutron target is shortened, the service life of the single neutron target is greatly prolonged, the maintenance period of the whole machine is greatly prolonged, and the maintenance cost is reduced.
3. The invention finds an optimal balance point which gives consideration to generality and particularity on the design of the stripping target, reforms the double-stripping-target single-circle leading-out technology in the prior art and uses the reformed double-stripping-target single-circle leading-out technology in the BNCT beam multi-circle leading-out technology, and particularly reserves the symmetrical 180-degree setting characteristic of the double-stripping-target in the prior art, thereby meeting the different flow intensity distribution requirements of BNCT treatment and medicine production; the characteristic that the position of the double stripping target is dynamically adjustable is reformed, and the position of the stripping target is dynamically adjustable and is changed into that the position of the stripping target is fixed and has the same position, so that the structure of the stripping target is effectively simplified and the cost is reduced; the characteristic of fixed length of the stripping film in the prior art is reformed, and the fixed length of the stripping film is reformed into adjustable length, so that the lengths of the two stripping films can be combined randomly according to needs, and the requirements of diversified treatment and drug production are met.
Drawings
Fig. 1-1 is a top view of a 4 treatment chamber BNCT cancer treatment device based on a high-current cyclotron in accordance with the present invention;
fig. 1-2 are perspective views of the 4 treatment chamber BNCT cancer treatment device based on a high-current cyclotron according to the present invention;
FIGS. 1-3 are partial enlarged views of FIGS. 1-2;
FIG. 2-1 is a schematic view of the assembly of the peeling target and the vertical driving means of the present invention;
FIG. 2-2 is a schematic view of a release film on a release target of the present invention;
fig. 3-1 is a top view of an enlarged a of __ beam transmission lines of fig. 1-2 of the present invention;
fig. 3-2 is a perspective view of an enlarged a view __ of the beam delivery line of fig. 1-2 of the present invention;
FIG. 4-1 is a top view of the neutron target system of FIG. 1-2B enlarged __ of the present invention;
FIG. 4-2 is a perspective view of a neutron target system of the present invention from B enlargement __ of FIGS. 1-2;
FIG. 5-1 is a top view of the __ accelerator and a peel target of FIG. 1-1 of the present invention;
FIG. 5-2 is a perspective view of the __ accelerator and peel target of FIG. 1-1 of the present invention;
figure 6 is a schematic view of a prior art BNCT cancer treatment apparatus with 2 treatment chambers;
FIG. 7 is a schematic view of the integrated control system of the present invention;
in the figure: 1: a 14MeV high current cyclotron; 2: a beam transmission line; 2-1: a beam line; 2-2: a guide magnet; 2-3: a quaternary lens; 2-4: a switch magnet; 2-5: rotating the magnet; 2-6: a radioisotope production target mechanism; 2-6-1: a radioisotope production target; 2-6-2: rabbit running pipelines; 3: a neutron target system; 3-1: a neutron target; 3-2: a moderator; 4: an accelerator main body; 5: stripping the target; 5-1: a stripping frame; 5-1-1: stripping the film; 5-1-2: a trumpet-shaped positioning hole; 5-2: stripping the target spindle; 5-3: a vertical driving device; 6: a treatment room.
Detailed Description
1. The design principle of 'one device for two purposes': the invention skillfully utilizes the characteristic of the energy range of the 14MeV strong-flow cyclotron: the 14MeV energy range is suitableThe accelerator is used for neutron treatment and is also suitable for producing medicaments, the characteristic is utilized to realize multiple purposes, and things to be done by two accelerators are combined on the same accelerator, and the accelerator is specifically as follows: firstly, a beam line 2 is reformed, and a switch magnet 2-4 of the beam line is added18F and other radioactive isotope medicine production target mechanisms 2-6; second, a comprehensive control system is established as shown in fig. 7, which controls the two control subsystems to work in coordination, one for the pharmaceutical control subsystem and one for the therapeutic control subsystem. The integrated control system includes an integrated scheduling subsystem for controlling and monitoring the drug production process, controlling and monitoring the treatment process, and preventing interference or conflict between the two subsystems, and although the structure is complicated, the technology adopted by the integrated control system is conventional, so the integrated control system is not described in detail.
2. The invention relates to a structural design principle of a stripping target. The invention discloses a stripping target capable of rotating an angle, which comprises the following parts: patent No. 2021102834474, entitled peel target head structure for BNCT accelerator and method of mounting, is not repeated here. The stripping target structure is briefly described as follows, and as shown in fig. 2-1 and fig. 2-2, the stripping target leading-out structure (5) comprises an upper part, a middle part and a lower part, wherein the upper part is a stripping target frame 5-1, the middle part is a stripping target main shaft 5-2, and the lower part is a vertical driving device 5-3; each stripping target 5-1 is provided with a left stripping film and a right stripping film, one stripping film is for standby, and the other stripping film is used for stripping negative hydrogen particles under a working state; the invention sets two stripping target positions (the radius R on the accelerator is the same) to be the same and to be symmetrically arranged by 180 degrees. Theoretically, if the two stripping targets have the same position and the same length of the stripping film, the width or intensity of the beam flowing through the two stripping targets is 50% respectively, because the beam is in a multi-turn lead-out mode of advancing in a spiral line, when the beam reaches the first stripping target, only half of the beam close to the stripping film is stripped, and the half of the beam far away from the stripping film cannot be stripped; when the beam reaches the second stripping target, the radius of the spiral track is increased, and the radius position of the other half of the beam which is not stripped reaches the second stripping target is just at the position where the second stripping target is stripped, so that theoretically, when the two stripping targets are the same in position and the length of the stripping film is the same, the stripped beam accounts for 50% of the total area. Based on this principle, when it is necessary that the flow intensity of one peeling target passes through is small and the flow intensity of the other peeling target passes through is small, it is possible to realize distribution of different flow intensities by adjusting the length of the peeling film. The lengths of the two stripping target stripping films can be combined randomly according to requirements, for example, when one stripping target is used for treatment, the required flow intensity is relatively large, most of beam current can be distributed, and the length of the stripping film is wider; another release target is used for producing drugs, the flow rate required is relatively small, a small amount can be dispensed, and the length of the release film is shorter.
When two stripping targets need to work simultaneously, the two stripping targets are changed into a working state from 180-degree rotation at a non-working state by 90 degrees, and the stripping film is vertical to the beam direction at the working state, so that the stripping film can strip negative hydrogen particles to be changed into protons for treatment or drug production.
When one stripping target is required to work and the other stripping target does not work, the stripping target in the non-working state rotates by 90 degrees and is changed from being vertical to the beam direction to being parallel to the beam direction; the one side that the target beam current that peels off under non-operating condition flowed through is the one side that does not have tubaeform opening on the target of peeling off, because do not have the one side of tubaeform opening, its locating pin is wrapped up in the inside of peeling off the target frame, can not activated when the beam current flows through, tubaeform opening is tubaeform locating hole.
Compared with the telescopic stripping target in the prior art, the stripping target has a much simpler structure, firstly, the accelerator magnet yoke is not required to be perforated through a wall, the magnetic field is not damaged, the magnetic stripe remedial measure is not required, and much trouble is saved; secondly, the size of the beam current is controlled by the telescopic stripping target in an electric telescopic mode, the stripping target only needs to be replaced by stripping films with different lengths, and because the stripping target frame is installed and disassembled in a plug-in mode when the stripping films are replaced, the operation is very simple, and the cost is greatly reduced.
3. The invention relates to a design principle of a beam transmission line. As shown in fig. 6, which is a schematic view of a device of a treatment room 2 based on a 30MeV cyclotron of sumitomo in japan, it can be seen that each branch leading to the treatment room is formed by combining a plurality of guiding devices and a plurality of quadrupole lenses, and the number of components on each beam line of the present invention can be minimized, thereby reducing the cost, as shown in fig. 3-1, 3-2, 4-1, and 4-2, the beam line of the present invention shares 1 guiding magnet 2-2 and 1 quadrupole lens before branching, and after branching, only 1 rotating magnet 2-5 is separately provided on each branch to scan the neutron targets 3-1 and 3-2, compared with the prior art, the present invention replaces a plurality of components on each branch of the prior art with 1 rotating magnet on each branch, thereby greatly reducing the cost. The invention uses a rotary magnet to scan a neutron target, and is based on the requirements of clinical treatment: clinical treatment requires that the diameter of the neutron target is larger than the diameter of the cluster (generally, the diameter of the neutron target is 8 cm, and the diameter of the cluster is only 1 cm), because the local skin is burnt out if the current intensity of 1 milliampere is always concentrated on one point in the treatment time, and if the current intensity of 1 milliampere is spread, the diameter of the neutron target is required to be far larger than the diameter of the cluster. If the diameter of the beam group is 1 cm, the spiral magnets are tightly connected without gaps between every two circles, so that 4 circles of scanning are needed to reach the diffusion area of 8 cm, and the purpose of uniform beam diffusion is achieved.
4. The difference between the stripping target of the invention and the stripping target of the prior art is as follows: the stripping target in the prior art is long rod type and is dynamically adjustable in position, the stripping target is designed to solve the error problem of theory and practice and meet the requirement of high-precision beam single-circle extraction, for example, the quality requirement of a part of physical experiments on the extracted proton beam is high, the single-circle extraction is required to be realized to obtain high beam quality, and the double-stripping target dynamic position adjustment is adopted to accurately calculate the position of the residual beam which is not stripped off from the first stripping target and reaches the second stripping target, so that the residual beam is completely extracted at the position of the second stripping target, and the purpose of 100% single-circle extraction is achieved. The two stripping target positions are designed to be fixed and have the same radius, and the requirement of the BNCT treatment on the beam current intensity and the coarse granularity is met, the requirement of the BNCT treatment on the beam current intensity is an accumulative effect, if the beam current intensity does not reach 50% but 40%, the treatment time can be prolonged to compensate, so theoretical and actual errors can be ignored, and the position of the stripping target does not need to be dynamically adjusted. Therefore, the invention can adopt a mode of replacing a long-rod telescopic stripping target with a double stripping target with a fixed position and a rotatable angle, and meets the requirement of distributing different flow intensities by adjusting the length of the stripping film.
Based on the principle, the invention designs a BNCT cancer treatment device with a 4 treatment rooms based on a strong-flow cyclotron.
A BNCT cancer treatment device based on a 4 treatment chambers of a strong-flow cyclotron is shown in figures 1-1, 1-2, 1-3, 2-1, 2-2, 3-1, 3-2, 4-1, 4-2, 5-1 and 5-2, and is characterized in that: the device comprises a cyclotron 1 for generating negative hydrogen ions, a stripping target leading-out structure 5 for stripping the negative hydrogen ions into protons, a beam transmission line 2 for sending beam to a treatment room 6, and a neutron target system 3 for uniformly capturing proton beams; the stripping target leading-out structure 5 is provided with 2 stripping targets which are symmetrically arranged on the cyclotron 1 at 180 degrees; the beam transmission lines 2 are 2, one end of each beam transmission line is led out from the stripping target, and the other end of each beam transmission line is connected with the neutron target system 3; the number of the neutron target systems 3 and the number of the treatment chambers 6 are respectively 4, each neutron target system 3 is connected with one treatment chamber, and each beam transmission line 2 corresponds to 2 neutron target systems 3 and 2 treatment chambers;
the method is characterized in that:
the peeling target leading-out structure 5 is a peeling target leading-out structure 5 which can rotate at an angle and has an adjustable peeling film length, as shown in fig. 5-1 and 5-2; the tail end of the beam transmission line 2 is provided with a rotating magnet 2-5, and the beam is scanned on the neutron target in a spiral line type or a circular shape through the rotating magnet 2-4, so that the beam is uniformly distributed on the target.
The beam transmission line 2 is a beam line with a radioisotope production target mechanism 2-6, as shown in FIGS. 3-1 and 3-2, the radioisotope production target mechanism 2-6 producing18F radioactive isotope and transferring into the synthesis chamber18F-BPA、18F-BSH、18Synthesizing F-FDG; the band of radioactivityThe beam transmission line 2 of the isotope production target mechanism 2-6 comprises two beam pipelines 2-1 which are symmetrically arranged at 180 degrees, each beam pipeline 2-1) comprises 1 main line and 2 branches, a pair of X-Y guide magnets 2-2, a pair of four-stage lens groups 2-3, an extraction switch magnet 2-4, two rotary magnets 2-5 extracted from the extraction switch magnet 2-4 and a radioactive isotope production target mechanism 2-6 extracted from a middle pore channel of the extraction switch magnet 2-4; the beam led out by the cyclotron 1 is transmitted through a beam pipeline 2-1; the pair of X-Y guiding magnets 2-2 realizes the control of the transmission direction of the beam flow; the pair of four-stage lens groups 2-3 realizes the control of beam envelope; the leading-out switch magnet 2-4 is used for the radioisotope production target mechanism 2-6 in a time-sharing mode, and respectively transmits the beam current to the two neutron target systems in a time-sharing mode, spiral line type or circular scanning of the beam current on the neutron target is achieved through the rotating magnet 2-5, and finally uniform distribution of the beam current on the target is achieved.
The radioisotope production target mechanism 2-6 is shown in fig. 1-3, and comprises a radioisotope production target 2-6-1 and a rabbit running pipeline 2-6-2, wherein the radioisotope production target 2-6-1 generates 18F radioisotope, and the 18F radioisotope is transmitted to a synthesis chamber through the rabbit running pipeline 2-6-2 for carrying out synthesis18F-BPA、18F-BSH、18Synthesizing F-FDG; when the treatment room is not in operation, the beam current led out from the cyclotron 1 is transmitted to a radioactive isotope production target 2-6-1 through a transmission line 2, and 18F radioactive isotopes are produced by targeting.
The peeling target leading-out structure 5 is provided with a peeling film 5-1 and a set of vertical driving devices 5-2 on one side as shown in figures 2-1 and 2-2; the angle of rotation of the peeling and leading-out structure 5 is as follows: when the stripping target is in a non-working state, the plane of the stripping film is parallel to the beam direction by 180 degrees, and when the stripping target is in a working state, the stripping target rotates by 90 degrees, so that the plane of the stripping film is perpendicular to the beam direction by 90 degrees.
The length of the stripping film is adjustable: the length of the stripping film is adjusted according to different requirements of the treatment chambers symmetrically arranged at 180 degrees on beam current intensity, wherein the length of the stripping film at one end requiring strong current is relatively long, and the length of the stripping film at one end requiring small current is relatively short.
Example one
As shown in figures 1-1 and 1-2, the invention provides a 4 treatment room BNCT cancer diagnosis and treatment comprehensive device structure based on a strong current cyclotron, which comprises a cyclotron 1, a beam transmission line 2, a neutron target system 3 and a radiopharmaceutical production target system 2-6. The cyclotron 1 is connected with a beam transmission line 2, and the beam transmission line 2 is connected with a neutron target system 3. The cyclotron includes an accelerator body 4 and a peeling target 5. The peeling target 5 has two peeling films thereon. The stripping target can rotate to adjust the direction of the extracted beam current.
As shown in fig. 2-1 and 2-2, the beam transmission lines 2 are led out in two directions by using switch magnets 2-4, and each beam transmission line shares a set of X-Y guide magnets 2-2 and four-stage lenses 2-3, so that the manufacturing cost of the beam transmission lines is reduced.
It should be emphasized that the described embodiments of the present invention are illustrative rather than limiting and, thus, the present invention includes embodiments that are not limited to those described in the detailed description.
Claims (5)
1. A4 treatment room BNCT cancer treatment device based on a strong flow cyclotron is characterized in that: the device comprises a cyclotron (1) for generating negative hydrogen ions, a stripping target leading-out structure (5) for stripping the negative hydrogen ions into protons, a beam transmission line (2) for sending beam to a treatment room (6), and a neutron target system (3) for uniformly capturing proton beams; the stripping target leading-out structure (5) is provided with 2 stripping targets which are symmetrically arranged on the cyclotron (1) at 180 degrees; the number of the beam transmission lines (2) is 2, one end of each beam transmission line is led out from the stripping target, and the other end of each beam transmission line is connected with the neutron target system (3); the number of the neutron target systems (3) and the number of the treatment chambers (6) are respectively 4, each neutron target system (3) is connected with one treatment chamber, and each beam current transmission line (2) corresponds to 2 neutron target systems (3) and 2 treatment chambers;
the method is characterized in that: the stripping target leading-out structure (5) can rotate by an angle, and the length of a stripping film can be adjusted; the tail end of the beam transmission line (2) is provided with a rotating magnet (2-5), and the beam is scanned on the neutron target in a spiral line type or a circular shape through the rotating magnet (2-4), so that the beam is uniformly distributed on the target finally.
2. The BNCT cancer therapy device for 4 treatment rooms based on high-current cyclotron as claimed in claim 1, wherein: the beam transmission line (2) is a beam line with a radioactive isotope production target mechanism (2-6), and the radioactive isotope production target mechanism (2-6) generates18F radioactive isotope and transferring into the synthesis chamber18F-BPA、18F-BSH、18Synthesizing F-FDG; the beam transmission line (2) with the radioisotope production target mechanism (2-6) comprises two beam pipelines (2-1) which are symmetrically arranged at 180 degrees, each beam pipeline (2-1) comprises 1 trunk line and 2 branches, a pair of X-Y guide magnets (2-2), a pair of four-stage lens groups (2-3), a lead-out switch magnet (2-4), two rotating magnets (2-5) led out from the lead-out switch magnet (2-4), and a radioisotope production target mechanism (2-6) led out from a middle pore channel of the lead-out switch magnet (2-4); the beam led out by the cyclotron (1) is transmitted through a beam pipeline (2-1); the pair of X-Y guiding magnets (2-2) realizes the control of the beam transmission direction; the pair of four-stage lens groups (2-3) realizes the control of beam envelope; the extraction switch magnet (2-4) is used for the radioisotope production target mechanism (2-6) in a time-sharing mode, and respectively transmits the beam to the two neutron target systems in a time-sharing mode, spiral line type or circular scanning of the beam on the neutron target is achieved through the rotating magnet (2-5), and finally uniform distribution of the beam on the target is achieved.
3. The BNCT cancer therapy device for 4 treatment rooms based on high-current cyclotron as claimed in claim 1, wherein: the radioisotope production target mechanism (2-6) comprises a radioisotope production target (2-6-1) and a rabbit running pipeline (2-6-2), wherein the radioisotope production target (2-6-1) is generated18F radioactive isotope and is transported to the synthesis chamber through a rabbit running pipeline (2-6-2)18F-BPA、18F-BSH、18Synthesizing F-FDG;when the treatment room does not work, the beam current led out from the cyclotron (1) is transmitted to a radioisotope production target (2-6-1) through a transmission line (2), and the target is shot to generate18A radioactive isotope of F.
4. The device for BNCT cancer treatment in a 4 treatment room based on a high-flow cyclotron according to claim 1, wherein: the peeling target leading-out structure (5) is provided with a peeling film (5-1) and a set of vertical driving device (5-2) on one side; the rotatable angle of the stripping and leading-out structure (5) is as follows: when the stripping target is in a non-working state, the plane of the stripping film is parallel to the beam direction by 180 degrees, and when the stripping target is in a working state, the stripping target rotates by 90 degrees, so that the plane of the stripping film is perpendicular to the beam direction by 90 degrees.
5. The device for BNCT cancer treatment in a 4 treatment room based on a high-flow cyclotron according to claim 1, wherein: the length of the stripping film is adjustable: the length of the stripping film is adjusted according to different requirements of the treatment chambers symmetrically arranged at 180 degrees on beam current intensity, wherein the length of the stripping film at one end requiring strong current is relatively long, and the length of the stripping film at one end requiring small current is relatively short.
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