CN113616611A - Preparation method of fermented cordyceps sinensis powder-containing CS-4 tablet - Google Patents
Preparation method of fermented cordyceps sinensis powder-containing CS-4 tablet Download PDFInfo
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Abstract
The invention aims to provide a preparation method of a tablet containing fermented cordyceps sinensis CS-4. According to the invention, the cordyceps sinensis powder amount of the prescription is controlled to be 80%, different binders are adopted for granulation and forming, process research is carried out according to the type and the amount of the binders, the addition mode and the granulation mode of the cordyceps sinensis powder, process screening is carried out according to a single-factor investigation method, and the optimal binder and the amount as well as the addition mode of the cordyceps sinensis powder are determined. The medicine prepared by the invention has the characteristics of strong anti-hygroscopicity capability, strong stability, stable curative effect and the like.
Description
Technical Field
The invention belongs to the technical field of medicines, and relates to a preparation method of a tablet containing fermented cordyceps sinensis powder CS-4. .
Technical Field
The cordyceps sinensis is a unique rare Chinese medicinal material in China. The fermented cordyceps sinensis (Cs-4) powder is derived from cordyceps sinensis and is superior to cordyceps sinensis, and the chemical components of the fermented cordyceps sinensis (Cs-4) powder are closest to those of natural cordyceps sinensis in the prior literature report. Fermented Cordyceps powder (Cs-4) is prepared by extracting natural Cordyceps by Jiangxi national drug limited company (original Jiangxi national pharmaceutical factory) with normal temperature biological fermentation technology, fermenting to obtain fermented Cordyceps powder (Cs-4), pulverizing, and refining. The invention defines the fermented cordyceps sinensis powder as fermented cordyceps sinensis powder (Cs-4), also called cordyceps sinensis powder.
Fermented cordyceps sinensis powder (Cs-4) as a medicine with Chinese characteristics represents a new achievement of medicine research and application in China, but with rapid development of science and technology and continuous improvement of material culture requirements of people, the cordyceps sinensis powder content of a tablet in the traditional process is about 60%, the proportion of auxiliary materials is about 40%, and if the auxiliary materials are used too much, the tablet is not good and sufficient, has slow effect and slight adverse effect. The traditional process for preparing the tablet containing 80% of cordyceps sinensis powder has the problem of poor formability, and the amount of the binder needs to be increased to meet the hardness requirement and meet the forming requirement. The following three ideas and ideas are thus created. The first idea is: the amount of the calcium sulfate and the aluminum hydroxide is reduced to increase the amount of the adhesive, and the absorbent is added properly, so that the amount of the adhesive can be increased to meet the hardness requirement. The second idea is: after part of the bacterial powder is extracted, the amount of dry matter is reduced by nearly half by adding the clear paste, so that the amount of the adhesive can be increased to meet the requirement of hardness. The third idea is: dry granulation can minimize or eliminate the use of calcium sulfate and aluminum hydroxide, thereby maximizing the use of the binder and meeting the hardness requirement.
The invention aims to provide a method for preparing a tablet containing 80% of fermented cordyceps sinensis powder CS-4, which is suitable for reducing the dosage of auxiliary materials, is easy to form and meets the requirement, and improves the curative effect.
Disclosure of Invention
The invention aims to provide a preparation method of a tablet containing fermented cordyceps sinensis CS-4.
According to the invention, the cordyceps sinensis powder amount of the prescription is controlled to be 80%, different binders are adopted for granulation and forming, process research is carried out according to the type and the amount of the binders, the addition mode and the granulation mode of the cordyceps sinensis powder, process screening is carried out according to a single-factor investigation method, and the optimal binder and the amount as well as the addition mode of the cordyceps sinensis powder are determined.
The purpose of the invention is realized as follows: the prescription and the process are continuously optimized, other factors are fixed, the adhesive in the prescription is investigated, then the single factor investigation is carried out on the dosage of the adhesive, and after the adhesive is determined, the prescription is finely adjusted, so that the amount of the cordyceps sinensis powder in the prescription is controlled to be 80%. Through technological innovation, the molding process research is carried out by investigating the adding mode and the granulating mode of the fermented cordyceps sinensis powder.
The tablet of the invention comprises four preparation methods, which are respectively as follows:
1) the first prescription and the preparation method are as follows: 200 parts of CS-4 fermented cordyceps sinensis powder, 6-8 parts of microcrystalline cellulose, 10-15 parts of Arabic gum, 25-30 parts of silicon dioxide and 1-3 parts of magnesium stearate, and the steps are as follows: preparing arabic gum into 10% arabic gum water solution as adhesive; dry mixing CS-4 fermented Cordyceps powder with microcrystalline cellulose and silicon dioxide for 3-7 min; adding prepared 10% acacia water solution, wet mixing for 2-4 min, granulating with 18 mesh sieve, drying to water content of 4-6%, grading with 18 mesh sieve, adding magnesium stearate, mixing, tabletting, and coating with sugar.
2) The second prescription and the preparation method are as follows: the preparation method comprises the following steps of preparing 250 parts of CS-4 fermented cordyceps sinensis powder, 8-12 parts of calcium sulfate, 8-12 parts of aluminum hydroxide, 10-15 parts of microcrystalline cellulose, 1-3 parts of hydroxypropyl methylcellulose, 5-7 parts of sodium carboxymethylcellulose, 18-22 parts of silicon dioxide and 1-3 parts of magnesium stearate, and comprises the following steps: wherein 150 parts of CS-4 fermented cordyceps sinensis powder is placed in a 5L distillation flask, extracted for 1 hour by 8 times of 85% ethanol, alcohol extract is collected, then extracted for 1 hour by 8 times of 50% ethanol under reflux, filtered, alcohol extract is collected, and the alcohol extract is merged and concentrated into extract under reduced pressure; adding 8 times of water into the residue, boiling for 1 hr, filtering, concentrating the decoction under reduced pressure to obtain extract, and mixing the extracts to obtain fluid extract. The sodium carboxymethylcellulose is prepared into a 5% sodium carboxymethylcellulose aqueous solution, and the hydroxypropyl methylcellulose is added to be uniformly stirred to obtain an adhesive solution for later use. Dry mixing 100 parts of CS-4 fermented cordyceps sinensis powder, calcium sulfate, aluminum hydroxide, microcrystalline cellulose and silicon dioxide for 3-7 minutes; adding the fluid extract and prepared binder solution, wet mixing for 2-4 min, granulating with 18 mesh sieve, drying to water content of 4-6%, grading with 18 mesh sieve, adding magnesium stearate, mixing, tabletting, and coating with sugar.
3) The method comprises the following three prescriptions: the preparation method comprises the following steps of preparing 300 parts of CS-4 fermented cordyceps sinensis powder, 18-22 parts of calcium sulfate, 18-22 parts of aluminum hydroxide, 2-4 parts of microcrystalline cellulose, 1-3 parts of hydroxypropyl methylcellulose, 6-10 parts of sodium carboxymethylcellulose, 18-22 parts of silicon dioxide and 1-3 parts of magnesium stearate, and comprises the following steps: wherein 150 parts of CS-4 fermented cordyceps sinensis powder is placed in a 5L distillation flask, extracted for 1 hour by 8 times of 80% ethanol, alcohol extract is collected, then extracted for 1 hour by 8 times of 60% ethanol under reflux, filtered, alcohol extract is collected, and the alcohol extract is merged and concentrated into extract under reduced pressure; adding 8 times of water into the residue, boiling for 1 hr, filtering, concentrating the decoction under reduced pressure to obtain extract, and mixing the extracts to obtain fluid extract. Adding water into the hydroxypropyl methylcellulose, the sodium carboxymethylcellulose and the clear paste to 170 parts of adhesive, and dry-mixing 150 parts of CS-4 fermented cordyceps sinensis powder, calcium sulfate, aluminum hydroxide, microcrystalline cellulose and silicon dioxide for 3-7 minutes; adding the prepared binder solution, wet mixing for 2-4 min, granulating with 18 mesh sieve, drying to water content of 4-6%, granulating with 18 mesh sieve, adding magnesium stearate, mixing, tabletting, and coating with sugar.
4) The fourth prescription and the preparation method are as follows: 200 parts of CS-4 fermented cordyceps sinensis powder, 8-10 parts of calcium sulfate, 8-10 parts of aluminum hydroxide, 4-8 parts of microcrystalline cellulose, 1-3 parts of hydroxypropyl methylcellulose, 18-22 parts of Arabic gum and 1-3 parts of magnesium stearate, and the method comprises the following steps: dry-mixing CS-4 fermented Cordyceps powder, calcium sulfate, aluminum hydroxide, microcrystalline cellulose, hypromellose and acacia for 3-7 min, granulating with a dry granulator, adding magnesium stearate, mixing, tabletting, and coating with sugar.
The preparation method is obtained by experimental screening and mainly comprises a wet granulation screening experiment and a dry granulation screening experiment, wherein the specific screening process comprises the following steps:
wet granulation screening experiment process
Mixing fermented Cordyceps powder and adjuvants, adding binder (or adding fermented Cordyceps powder fluid extract), stirring, granulating, drying, adding lubricant, mixing, and tabletting. Thus obtaining the plain tablets containing the fermented cordyceps sinensis CS-4 tablets. And (5) carrying out process screening.
Auxiliary materials: one or more of calcium sulfate, aluminum hydroxide, microcrystalline cellulose, silicon dioxide, etc.
Fermented cordyceps sinensis powder clear paste: putting 1500g of fermented cordyceps sinensis powder into a 5L distillation flask, extracting for 1 hour by using 85% ethanol in an amount which is 8 times that of the fermented cordyceps sinensis powder, and filtering to obtain an ethanol extract; reflux-extracting with 8 times of 50% ethanol for 1 hr, filtering, collecting the ethanol extractive solution, mixing the ethanol extractive solutions, and concentrating to appropriate amount; adding 8 times of water into the residue, boiling for 1 hr, filtering, mixing the decoction and the ethanol extract, and concentrating under reduced pressure to obtain fluid extract of 1500 g.
Adhesive: one or more of hypromellose water solution, carboxymethyl cellulose water solution, acacia water solution, fermented Cordyceps powder fluid extract, etc.
Lubricant: magnesium stearate, and the like.
And (3) judging standard: appearance judgment standard: the cracking and the holes are unqualified, and the surface is smooth and qualified without powder falling. A hardness of less than 4.5kg is "unacceptable", and a hardness of 4.5kg or more is "acceptable". Determination standard of disintegration time limit: disintegration was "off-specification" for more than 20 minutes and "acceptable" for no more than 20 minutes. The weight difference determination standard is as follows: weight variation of not more than. + -. 5% was "acceptable", and weight variation of more than. + -. 5% was "unacceptable".
The specific experimental prescription is shown in the following table.
From the above experimental results it can be seen that:
each index of the plain film of the scheme 14, the scheme 25 and the scheme 29 meets the requirement, and the process is feasible. That is, the first method, the second method and the third method of the present invention are shown in scheme 14, scheme 25 and scheme 29, respectively.
Second, dry granulation screening experiment process
Mixing fermented Cordyceps powder with adjuvants and binder, granulating by dry method, drying, adding lubricant, mixing, and tabletting. Thus obtaining the plain tablets containing the fermented cordyceps sinensis CS-4 tablets. And (5) carrying out process screening.
Auxiliary materials: one or more of calcium sulfate, aluminum hydroxide, microcrystalline cellulose, etc.
Adhesive: one or more of hypromellose, carboxymethyl cellulose, acacia, etc.
Lubricant: magnesium stearate, and the like.
And (3) judging standard: appearance judgment standard: the cracking and the holes are unqualified, and the surface is smooth and qualified without powder falling. A hardness of less than 4.5kg is "unacceptable", and a hardness of 4.5kg or more is "acceptable". Determination standard of disintegration time limit: disintegration was "off-specification" for more than 20 minutes and "acceptable" for no more than 20 minutes. The weight difference determination standard is as follows: weight variation of not more than. + -. 5% was "acceptable", and weight variation of more than. + -. 5% was "unacceptable".
The specific experimental prescription is shown in the following table.
Third, experimental research screening results
Through the experiments, the following optimal preparation method of the fermented cordyceps sinensis powder-containing CS-4 tablet is screened out. See the following Table
According to the screening result method, a small experiment is performed to verify and investigate the quality indexes such as the appearance, the hardness, the disintegration time limit, the weight difference, the content and the like of the plain tablets, and the specific experiment and result are as follows:
the experiments prove that the screened preparation method of the CS-4 tablet containing the fermented cordyceps sinensis bacteria powder meets the requirements of the first method, the second method, the third method and the fourth method, so that the screened first method, the screened second method, the screened third method and the screened fourth method can prepare the CS-4 tablet containing the fermented cordyceps sinensis bacteria powder meeting the requirements.
Therefore, the invention provides four preparation methods of the fermented cordyceps sinensis powder-containing CS-4 tablets.
1) The method comprises the following steps: the preparation method comprises the following steps: 10-15 parts of Arabic gum is prepared into a 10% Arabic gum aqueous solution for later use; 200 parts of CS-4 fermented cordyceps sinensis powder, 6-8 parts of microcrystalline cellulose and 25-30 parts of silicon dioxide are dry-mixed for 3-7 minutes; adding prepared 10% acacia gum water solution, wet mixing for 2-4 minutes, granulating with 18 mesh sieve, drying to water content of 4-6%, grading with 18 mesh sieve, adding 1-3 parts magnesium stearate, mixing, tabletting, and coating with sugar.
2) The second method comprises the following steps: the preparation method comprises the following steps: putting 150 parts of CS-4 fermented cordyceps sinensis powder into a 5L distillation flask, extracting with 8 times of 85% ethanol for 1 hour, collecting an ethanol extract, performing reflux extraction with 8 times of 50% ethanol for 1 hour, filtering, collecting the ethanol extract, combining the ethanol extracts, and concentrating under reduced pressure to obtain an extract; adding 8 times of water into the residue, boiling for 1 hr, filtering, concentrating the decoction under reduced pressure to obtain extract, and mixing the extracts to obtain fluid extract. 5-7 parts of sodium carboxymethylcellulose are prepared into a 5% sodium carboxymethylcellulose aqueous solution, and 1-3 parts of hydroxypropyl methylcellulose is added and uniformly stirred to obtain an adhesive solution for later use. 100 parts of CS-4 fermented cordyceps sinensis powder, 8-12 parts of calcium sulfate, 8-12 parts of aluminum hydroxide, 10-15 parts of microcrystalline cellulose and 18-22 parts of silicon dioxide are dry-mixed for 3-7 minutes; adding the fluid extract and prepared binder solution, wet mixing for 2-4 minutes, granulating with 18 mesh sieve, drying to water content of 4-6%, grading with 18 mesh sieve, adding 1-3 parts of magnesium stearate, mixing, tabletting, and coating with sugar.
3) The third method comprises the following steps: the preparation method comprises the following steps: putting 150 parts of CS-4 fermented cordyceps sinensis powder into a 5L distillation flask, extracting with 8 times of 80% ethanol for 1 hour, collecting an ethanol extract, performing reflux extraction with 8 times of 60% ethanol for 1 hour, filtering, collecting the ethanol extract, combining the ethanol extracts, and concentrating under reduced pressure to obtain an extract; adding 8 times of water into the residue, boiling for 1 hr, filtering, concentrating the decoction under reduced pressure to obtain extract, and mixing the extracts to obtain fluid extract. 1-3 parts of hydroxypropyl methylcellulose, 6-10 parts of sodium carboxymethylcellulose and clear paste are added with water to 170 parts of adhesive, and 150 parts of CS-4 fermented cordyceps powder, 18-22 parts of calcium sulfate, 18-22 parts of aluminum hydroxide, 2-4 parts of microcrystalline cellulose and 18-22 parts of silicon dioxide are dry-mixed for 3-7 minutes; adding the prepared binder solution, wet mixing for 2-4 minutes, granulating with 18 mesh sieve, drying to water content of 4-6%, granulating with 18 mesh sieve, adding 1-3 parts of magnesium stearate, mixing, tabletting, and coating with sugar.
4) The method four comprises the following steps: the preparation method comprises the following steps: 200 parts of CS-4 fermented cordyceps sinensis powder, 8-10 parts of calcium sulfate, 8-10 parts of aluminum hydroxide, 4-8 parts of microcrystalline cellulose, 1-3 parts of hydroxypropyl methylcellulose and 18-22 parts of Arabic gum are dry-mixed for 3-7 minutes, and after uniform mixing, the mixture is granulated by using a dry-method granulator, added with 1-3 parts of magnesium stearate, mixed, tableted and coated to obtain the cordyceps sinensis powder.
Wherein, the parts of the raw and auxiliary materials are parts by weight, and can be in units of g, kg and the like.
Wherein, the gum arabic is 10% in water solution; the concentration of 10% is a mass percentage concentration, and for example, 10g of gum arabic is added with water to 100g to prepare a 10% gum arabic aqueous solution. 5% sodium carboxymethylcellulose aqueous solution; 5% As a concentration percentage, for example, 5g of sodium carboxymethylcellulose was added with water to 100g to prepare a 5% sodium carboxymethylcellulose aqueous solution. The same applies to the others.
Selecting the samples prepared by the first method, the second method, the third method and the fourth method to prepare the finished product of the fermented cordyceps sinensis powder-CS-4 tablet, and carrying out accelerated stability investigation under the following investigation conditions: standing at 40 + -2 deg.C and 75% + -5% relative humidity for 6 months. Samples were taken at month 0, month 3 and month 6 of the test period and examined.
In order to better embody the advancement of the invention, the invention adopts a comparative research form and carries out comparative research with other samples.
Comparative Experimental conditions
From all the data analyses above, it follows: the sample prepared by the optimal process has better stability than the standard process, and the obtained product has strong moisture-attracting resistance, strong stability and stable curative effect; the whole process is easy to operate and suitable for popularization and application.
Detailed Description
The present invention will be described in further detail with reference to examples.
Example 1: preparation method of fermented cordyceps sinensis powder-containing CS-4 tablet
12.5 parts of Arabic gum is prepared into a 10% Arabic gum aqueous solution for later use; 200 parts of CS-4 fermented cordyceps sinensis powder, 8 parts of microcrystalline cellulose and 27.5 parts of silicon dioxide are dry-mixed for 5 minutes; adding prepared 10% acacia gum water solution, wet mixing for 3 min, granulating with 18 mesh sieve, drying to water content of 4-6%, granulating with 18 mesh sieve, adding 2 parts magnesium stearate, mixing, tabletting, and coating with sugar.
Example 2: preparation method of fermented cordyceps sinensis powder-containing CS-4 tablet
Putting 150 parts of CS-4 fermented cordyceps sinensis powder into a 5L distillation flask, extracting with 8 times of 85% ethanol for 1 hour, collecting an ethanol extract, performing reflux extraction with 8 times of 50% ethanol for 1 hour, filtering, collecting the ethanol extract, combining the ethanol extracts, and concentrating under reduced pressure to obtain an extract; adding 8 times of water into the residue, boiling for 1 hr, filtering, concentrating the decoction under reduced pressure to obtain extract, and mixing the extracts to obtain fluid extract. 6 parts of sodium carboxymethylcellulose is prepared into a 5% sodium carboxymethylcellulose aqueous solution, and 2 parts of hydroxypropyl methylcellulose is added and uniformly stirred to obtain a binder solution for later use. 100 parts of CS-4 fermented cordyceps sinensis powder, 10 parts of calcium sulfate, 10 parts of aluminum hydroxide, 12.5 parts of microcrystalline cellulose and 20 parts of silicon dioxide are dry-mixed for 5 minutes; adding the fluid extract and prepared binder solution, wet mixing for 3 minutes, granulating with 18 mesh sieve, drying to water content of 4-6%, granulating with 18 mesh sieve, adding 2 parts of magnesium stearate, mixing, tabletting, and coating with sugar.
Example 3: preparation method of fermented cordyceps sinensis powder-containing CS-4 tablet
Putting 150 parts of CS-4 fermented cordyceps sinensis powder into a 5L distillation flask, extracting with 8 times of 80% ethanol for 1 hour, collecting an ethanol extract, performing reflux extraction with 8 times of 60% ethanol for 1 hour, filtering, collecting the ethanol extract, combining the ethanol extracts, and concentrating under reduced pressure to obtain an extract; adding 6 times of water into the residue, boiling for 1 hr, filtering, concentrating the decoction under reduced pressure to obtain extract, and mixing the extracts to obtain fluid extract. Adding water into 2 parts of hydroxypropyl methylcellulose, 8 parts of sodium carboxymethylcellulose and the clear paste to 170 parts of adhesive, and dry-mixing 150 parts of CS-4 fermented cordyceps sinensis powder, 20 parts of calcium sulfate, 20 parts of aluminum hydroxide, 3 parts of microcrystalline cellulose and 20 parts of silicon dioxide for 5 minutes; adding the prepared binder solution, wet mixing for 3 minutes, granulating with 18-mesh sieve, drying until the water content is 4-6%, granulating with 18-mesh sieve, adding 2 parts of magnesium stearate, mixing, tabletting, and coating with sugar.
Example 4: preparation method of fermented cordyceps sinensis powder-containing CS-4 tablet
200 parts of CS-4 fermented cordyceps sinensis powder, 10 parts of calcium sulfate, 10 parts of aluminum hydroxide, 6 parts of microcrystalline cellulose, 2 parts of hydroxypropyl methylcellulose and 20 parts of Arabic gum are dry-mixed for 5 minutes, and after the mixture is uniformly mixed, a dry-method granulator is used for granulating, 2 parts of magnesium stearate are added, and the mixture is subjected to total mixing, tabletting and sugar coating to obtain the cordyceps sinensis powder.
Example 5: preparation method of fermented cordyceps sinensis powder-containing CS-4 tablet
12 parts of Arabic gum are prepared into a 10% Arabic gum aqueous solution for later use; 200 parts of CS-4 fermented cordyceps sinensis powder, 8 parts of microcrystalline cellulose and 28 parts of silicon dioxide are dry-mixed for 5 minutes; adding prepared 10% acacia gum water solution, wet mixing for 3 min, granulating with 18 mesh sieve, drying to water content of 4-6%, granulating with 18 mesh sieve, adding 2 parts magnesium stearate, mixing, tabletting, and coating with sugar.
Example 6: preparation method of fermented cordyceps sinensis powder-containing CS-4 tablet
Putting 150 parts of CS-4 fermented cordyceps sinensis powder into a 5L distillation flask, extracting with 8 times of 85% ethanol for 1 hour, collecting an ethanol extract, performing reflux extraction with 8 times of 50% ethanol for 1 hour, filtering, collecting the ethanol extract, combining the ethanol extracts, and concentrating under reduced pressure to obtain an extract; adding 8 times of water into the residue, boiling for 1 hr, filtering, concentrating the decoction under reduced pressure to obtain extract, and mixing the extracts to obtain fluid extract. 7 parts of sodium carboxymethylcellulose is prepared into a 5% sodium carboxymethylcellulose aqueous solution, and 1 part of hydroxypropyl methylcellulose is added and uniformly stirred to obtain a binder solution for later use. 100 parts of CS-4 fermented cordyceps sinensis powder, 8 parts of calcium sulfate, 12 parts of aluminum hydroxide, 12.5 parts of microcrystalline cellulose and 20 parts of silicon dioxide are dry-mixed for 5 minutes; adding the fluid extract and prepared binder solution, wet mixing for 3 minutes, granulating with 18 mesh sieve, drying to water content of 4-6%, granulating with 18 mesh sieve, adding 2 parts of magnesium stearate, mixing, tabletting, and coating with sugar.
Example 7: preparation method of fermented cordyceps sinensis powder-containing CS-4 tablet
Putting 150 parts of CS-4 fermented cordyceps sinensis powder into a 5L distillation flask, extracting with 8 times of 80% ethanol for 1 hour, collecting an ethanol extract, performing reflux extraction with 8 times of 60% ethanol for 1 hour, filtering, collecting the ethanol extract, combining the ethanol extracts, and concentrating under reduced pressure to obtain an extract; adding 6 times of water into the residue, boiling for 1 hr, filtering, concentrating the decoction under reduced pressure to obtain extract, and mixing the extracts to obtain fluid extract. Adding water into 2 parts of hydroxypropyl methylcellulose, 8 parts of sodium carboxymethylcellulose and the clear paste to 170 parts of adhesive, and dry-mixing 150 parts of CS-4 fermented cordyceps sinensis powder, 18 parts of calcium sulfate, 22 parts of aluminum hydroxide, 4 parts of microcrystalline cellulose and 19 parts of silicon dioxide for 5 minutes; adding the prepared binder solution, wet mixing for 3 minutes, granulating with 18-mesh sieve, drying until the water content is 4-6%, granulating with 18-mesh sieve, adding 2 parts of magnesium stearate, mixing, tabletting, and coating with sugar.
Example 8: preparation method of fermented cordyceps sinensis powder-containing CS-4 tablet
200 parts of CS-4 fermented cordyceps sinensis powder, 8 parts of calcium sulfate, 12 parts of aluminum hydroxide, 6 parts of microcrystalline cellulose, 2 parts of hydroxypropyl methylcellulose and 20 parts of Arabic gum are dry-mixed for 5 minutes, and after uniform mixing, a dry granulator is used for granulation, 2 parts of magnesium stearate are added, and the mixture is subjected to total mixing, tabletting and sugar coating to obtain the cordyceps sinensis powder.
Example 9: preparation method of fermented cordyceps sinensis powder-containing CS-4 tablet
10 parts of Arabic gum is prepared into a 10% Arabic gum water solution for later use; 200 parts of CS-4 fermented cordyceps sinensis powder, 8 parts of microcrystalline cellulose and 30 parts of silicon dioxide are dry-mixed for 5 minutes; adding prepared 10% acacia gum water solution, wet mixing for 3 min, granulating with 18 mesh sieve, drying to water content of 4-6%, granulating with 18 mesh sieve, adding 2 parts magnesium stearate, mixing, tabletting, and coating with sugar.
Example 10: preparation method of fermented cordyceps sinensis powder-containing CS-4 tablet
Putting 150 parts of CS-4 fermented cordyceps sinensis powder into a 5L distillation flask, extracting with 8 times of 85% ethanol for 1 hour, collecting an ethanol extract, performing reflux extraction with 8 times of 50% ethanol for 1 hour, filtering, collecting the ethanol extract, combining the ethanol extracts, and concentrating under reduced pressure to obtain an extract; adding 8 times of water into the residue, boiling for 1 hr, filtering, concentrating the decoction under reduced pressure to obtain extract, and mixing the extracts to obtain fluid extract. 6 parts of sodium carboxymethylcellulose is prepared into a 5% sodium carboxymethylcellulose aqueous solution, and 2 parts of hydroxypropyl methylcellulose is added and uniformly stirred to obtain a binder solution for later use. 100 parts of CS-4 fermented cordyceps sinensis powder, 12 parts of calcium sulfate, 8 parts of aluminum hydroxide, 12.5 parts of microcrystalline cellulose and 20 parts of silicon dioxide are dry-mixed for 5 minutes; adding the fluid extract and prepared binder solution, wet mixing for 3 minutes, granulating with 18 mesh sieve, drying to water content of 4-6%, granulating with 18 mesh sieve, adding 2 parts of magnesium stearate, mixing, tabletting, and coating with sugar.
Example 11: preparation method of fermented cordyceps sinensis powder-containing CS-4 tablet
Putting 150 parts of CS-4 fermented cordyceps sinensis powder into a 5L distillation flask, extracting with 8 times of 80% ethanol for 1 hour, collecting an ethanol extract, performing reflux extraction with 8 times of 60% ethanol for 1 hour, filtering, collecting the ethanol extract, combining the ethanol extracts, and concentrating under reduced pressure to obtain an extract; adding 6 times of water into the residue, boiling for 1 hr, filtering, concentrating the decoction under reduced pressure to obtain extract, and mixing the extracts to obtain fluid extract. Adding water into 2 parts of hydroxypropyl methylcellulose, 8 parts of sodium carboxymethylcellulose and the clear paste to 170 parts of adhesive, and dry-mixing 150 parts of CS-4 fermented cordyceps sinensis powder, 22 parts of calcium sulfate, 18 parts of aluminum hydroxide, 3 parts of microcrystalline cellulose and 20 parts of silicon dioxide for 5 minutes; adding the prepared binder solution, wet mixing for 3 minutes, granulating with 18-mesh sieve, drying until the water content is 4-6%, granulating with 18-mesh sieve, adding 2 parts of magnesium stearate, mixing, tabletting, and coating with sugar.
Example 12: a preparation method of a fermented cordyceps sinensis powder-containing CS-4 tablet comprises the steps of dry-mixing 200 parts of CS-4 fermented cordyceps sinensis powder, 12 parts of calcium sulfate, 8 parts of aluminum hydroxide, 6 parts of microcrystalline cellulose, 2 parts of hydroxypropyl methylcellulose and 20 parts of Arabic gum for 5 minutes, granulating by using a dry granulator after uniformly mixing, adding 2 parts of magnesium stearate, mixing, tabletting and coating sugar.
Claims (10)
1. A preparation method of a tablet containing fermented cordyceps sinensis CS-4 is characterized by comprising the following steps:
the method comprises the following steps:
the formula is as follows: 200 parts of CS-4 fermented cordyceps sinensis powder, 6-8 parts of microcrystalline cellulose, 10-15 parts of Arabic gum, 25-30 parts of silicon dioxide and 1-3 parts of magnesium stearate,
the method comprises the following steps: preparing arabic gum into 10% arabic gum water solution as adhesive; dry mixing CS-4 fermented Cordyceps powder with microcrystalline cellulose and silicon dioxide for 3-7 min; adding prepared 10% acacia gum water solution, wet mixing for 2-4 min, granulating with 18 mesh sieve, drying to water content of 4-6%, grading with 18 mesh sieve, adding magnesium stearate, mixing, tabletting, and coating with sugar;
the second method comprises the following steps:
the formula is as follows: 250 parts of CS-4 fermented cordyceps sinensis powder, 8-12 parts of calcium sulfate, 8-12 parts of aluminum hydroxide, 10-15 parts of microcrystalline cellulose, 1-3 parts of hydroxypropyl methylcellulose, 5-7 parts of sodium carboxymethylcellulose, 18-22 parts of silicon dioxide and 1-3 parts of magnesium stearate,
the method comprises the following steps: wherein 150 parts of CS-4 fermented cordyceps sinensis powder is placed in a 5L distillation flask, extracted for 1 hour by 8 times of 85% ethanol, alcohol extract is collected, then extracted for 1 hour by 8 times of 50% ethanol under reflux, filtered, alcohol extract is collected, and the alcohol extract is merged and concentrated into extract under reduced pressure; adding 8 times of water into the residue, boiling for 1 hr, filtering, concentrating the decoction under reduced pressure to obtain extract, and mixing the extracts to obtain fluid extract; preparing 5% sodium carboxymethylcellulose aqueous solution from sodium carboxymethylcellulose, adding hypromellose, and stirring to obtain binder solution; dry mixing 100 parts of CS-4 fermented cordyceps sinensis powder, calcium sulfate, aluminum hydroxide, microcrystalline cellulose and silicon dioxide for 3-7 minutes; adding the fluid extract and prepared binder solution, wet mixing for 2-4 min, granulating with 18 mesh sieve, drying to water content of 4-6%, grading with 18 mesh sieve, adding magnesium stearate, mixing, tabletting, and coating with sugar;
the third method comprises the following steps:
the formula is as follows: 300 parts of CS-4 fermented cordyceps sinensis powder, 18-22 parts of calcium sulfate, 18-22 parts of aluminum hydroxide, 2-4 parts of microcrystalline cellulose, 1-3 parts of hydroxypropyl methylcellulose, 6-10 parts of sodium carboxymethylcellulose, 18-22 parts of silicon dioxide and 1-3 parts of magnesium stearate,
the method comprises the following steps: wherein 150 parts of CS-4 fermented cordyceps sinensis powder is placed in a 5L distillation flask, extracted for 1 hour by 8 times of 80% ethanol, alcohol extract is collected, then extracted for 1 hour by 8 times of 60% ethanol under reflux, filtered, alcohol extract is collected, and the alcohol extract is merged and concentrated into extract under reduced pressure; adding 8 times of water into the residue, boiling for 1 hr, filtering, concentrating the decoction under reduced pressure to obtain extract, and mixing the extracts to obtain fluid extract; adding water into the hydroxypropyl methylcellulose, the sodium carboxymethylcellulose and the clear paste to 170 parts of adhesive, and dry-mixing 150 parts of CS-4 fermented cordyceps sinensis powder, calcium sulfate, aluminum hydroxide, microcrystalline cellulose and silicon dioxide for 3-7 minutes; adding the prepared binder solution, wet mixing for 2-4 min, granulating with 18 mesh sieve, drying to water content of 4-6%, granulating with 18 mesh sieve, adding magnesium stearate, mixing, tabletting, and coating with sugar;
the method four comprises the following steps:
the formula is as follows: 200 parts of CS-4 fermented cordyceps sinensis powder, 8-10 parts of calcium sulfate, 8-10 parts of aluminum hydroxide, 4-8 parts of microcrystalline cellulose, 1-3 parts of hydroxypropyl methylcellulose, 18-22 parts of Arabic gum and 1-3 parts of magnesium stearate,
the method comprises the following steps: dry-mixing CS-4 fermented Cordyceps powder, calcium sulfate, aluminum hydroxide, microcrystalline cellulose, hypromellose and acacia for 3-7 min, granulating with a dry granulator, adding magnesium stearate, mixing, tabletting, and coating with sugar.
2. The preparation method of claim 1, wherein the first method comprises using gum arabic as a binder to prepare a sugar-coated tablet containing the CS-4 tablet of fermented cordyceps.
3. The preparation method according to claim 1, wherein the sugar-coated tablet containing the fermented cordyceps sinensis CS-4 tablet is prepared by uniformly stirring the sodium carboxymethylcellulose aqueous solution of 5% and hypromellose, and the obtained solution is a binder.
4. The preparation method according to claim 1, wherein the preparation method comprises the steps of extracting 150 parts of CS-4 fermented cordyceps sinensis powder with ethanol for 2 times, extracting with water for 1 time, concentrating under reduced pressure to obtain clear paste, and adding other dry matter raw and auxiliary materials and adhesives to prepare the sugar-coated tablet containing the CS-4 fermented cordyceps sinensis powder tablet.
5. The preparation method according to claim 1, characterized in that, in the third method, 150 parts of CS-4 fermented Cordyceps sinensis powder is extracted with ethanol for 2 times, extracted with water for 1 time, and concentrated under reduced pressure to obtain fluid extract; mixing the obtained fluid extract with hypromellose and sodium carboxymethylcellulose, adding water to 170 parts of solution as binder, and making into sugar-coated tablet containing fermented Cordyceps powder CS-4 tablet.
6. The preparation method of claim 1, wherein the gum arabic is used as a binder, and the sugar-coated tablet containing the fermented cordyceps sinensis CS-4 tablet is prepared by dry granulation.
7. The method of claim 1, comprising the steps of:
12.5 parts of Arabic gum is prepared into a 10% Arabic gum aqueous solution for later use; 200 parts of CS-4 fermented cordyceps sinensis powder, 8 parts of microcrystalline cellulose and 27.5 parts of silicon dioxide are dry-mixed for 5 minutes; adding prepared 10% acacia gum water solution, wet mixing for 3 min, granulating with 18 mesh sieve, drying to water content of 4-6%, granulating with 18 mesh sieve, adding 2 parts magnesium stearate, mixing, tabletting, and coating with sugar.
8. The method of claim 1, comprising the steps of:
putting 150 parts of CS-4 fermented cordyceps sinensis powder into a 5L distillation flask, extracting with 8 times of 85% ethanol for 1 hour, collecting an ethanol extract, performing reflux extraction with 8 times of 50% ethanol for 1 hour, filtering, collecting the ethanol extract, combining the ethanol extracts, and concentrating under reduced pressure to obtain an extract; adding 8 times of water into the residue, boiling for 1 hr, filtering, concentrating the decoction under reduced pressure to obtain extract, and mixing the extracts to obtain fluid extract; 6 parts of sodium carboxymethylcellulose is prepared into a 5% sodium carboxymethylcellulose aqueous solution, and 2 parts of hydroxypropyl methylcellulose is added and uniformly stirred to obtain a binder solution for later use; 100 parts of CS-4 fermented cordyceps sinensis powder, 10 parts of calcium sulfate, 10 parts of aluminum hydroxide, 12.5 parts of microcrystalline cellulose and 20 parts of silicon dioxide are dry-mixed for 5 minutes; adding the fluid extract and prepared binder solution, wet mixing for 3 minutes, granulating with 18 mesh sieve, drying to water content of 4-6%, granulating with 18 mesh sieve, adding 2 parts of magnesium stearate, mixing, tabletting, and coating with sugar.
9. The method of claim 1, comprising the steps of:
putting 150 parts of CS-4 fermented cordyceps sinensis powder into a 5L distillation flask, extracting with 8 times of 80% ethanol for 1 hour, collecting an ethanol extract, performing reflux extraction with 8 times of 60% ethanol for 1 hour, filtering, collecting the ethanol extract, combining the ethanol extracts, and concentrating under reduced pressure to obtain an extract; adding 6 times of water into the residue, boiling for 1 hr, filtering, concentrating the decoction under reduced pressure to obtain extract, and mixing the extracts to obtain fluid extract; adding water into 2 parts of hydroxypropyl methylcellulose, 8 parts of sodium carboxymethylcellulose and the clear paste to 170 parts of adhesive, and dry-mixing 150 parts of CS-4 fermented cordyceps sinensis powder, 20 parts of calcium sulfate, 20 parts of aluminum hydroxide, 3 parts of microcrystalline cellulose and 20 parts of silicon dioxide for 5 minutes; adding the prepared binder solution, wet mixing for 3 minutes, granulating with 18-mesh sieve, drying until the water content is 4-6%, granulating with 18-mesh sieve, adding 2 parts of magnesium stearate, mixing, tabletting, and coating with sugar.
10. The method of claim 1, comprising the steps of:
200 parts of CS-4 fermented cordyceps sinensis powder, 10 parts of calcium sulfate, 10 parts of aluminum hydroxide, 6 parts of microcrystalline cellulose, 2 parts of hydroxypropyl methylcellulose and 20 parts of Arabic gum are dry-mixed for 5 minutes, and after the mixture is uniformly mixed, a dry-method granulator is used for granulating, 2 parts of magnesium stearate are added, and the mixture is subjected to total mixing, tabletting and sugar coating to obtain the cordyceps sinensis powder.
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