CN113616414B - Punctal plug with adhesive coating and manufacturing process thereof - Google Patents
Punctal plug with adhesive coating and manufacturing process thereof Download PDFInfo
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- CN113616414B CN113616414B CN202110900863.4A CN202110900863A CN113616414B CN 113616414 B CN113616414 B CN 113616414B CN 202110900863 A CN202110900863 A CN 202110900863A CN 113616414 B CN113616414 B CN 113616414B
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- punctal plug
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- rod
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- 238000000576 coating method Methods 0.000 title claims abstract description 23
- 239000011248 coating agent Substances 0.000 title claims abstract description 21
- 239000000853 adhesive Substances 0.000 title claims abstract description 20
- 230000001070 adhesive effect Effects 0.000 title claims abstract description 20
- 238000004519 manufacturing process Methods 0.000 title description 4
- 239000010410 layer Substances 0.000 claims abstract description 35
- 239000012790 adhesive layer Substances 0.000 claims abstract description 31
- 238000000034 method Methods 0.000 claims abstract description 20
- 239000000126 substance Substances 0.000 claims abstract description 15
- 230000008569 process Effects 0.000 claims abstract description 12
- 239000003814 drug Substances 0.000 claims description 44
- 239000000463 material Substances 0.000 claims description 25
- 238000001035 drying Methods 0.000 claims description 19
- 230000003204 osmotic effect Effects 0.000 claims description 16
- 230000008093 supporting effect Effects 0.000 claims description 16
- 238000007789 sealing Methods 0.000 claims description 11
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 8
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 8
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 claims description 8
- 230000001464 adherent effect Effects 0.000 claims description 6
- 238000004108 freeze drying Methods 0.000 claims description 6
- 230000008878 coupling Effects 0.000 claims description 5
- 238000010168 coupling process Methods 0.000 claims description 5
- 238000005859 coupling reaction Methods 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 4
- GLNADSQYFUSGOU-GPTZEZBUSA-J Trypan blue Chemical compound [Na+].[Na+].[Na+].[Na+].C1=C(S([O-])(=O)=O)C=C2C=C(S([O-])(=O)=O)C(/N=N/C3=CC=C(C=C3C)C=3C=C(C(=CC=3)\N=N\C=3C(=CC4=CC(=CC(N)=C4C=3O)S([O-])(=O)=O)S([O-])(=O)=O)C)=C(O)C2=C1N GLNADSQYFUSGOU-GPTZEZBUSA-J 0.000 claims description 4
- 239000001110 calcium chloride Substances 0.000 claims description 4
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 4
- 235000011148 calcium chloride Nutrition 0.000 claims description 4
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical group O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 claims description 4
- 239000001103 potassium chloride Substances 0.000 claims description 4
- 235000011164 potassium chloride Nutrition 0.000 claims description 4
- 239000011780 sodium chloride Substances 0.000 claims description 4
- 235000002639 sodium chloride Nutrition 0.000 claims description 4
- 239000011592 zinc chloride Substances 0.000 claims description 4
- 235000005074 zinc chloride Nutrition 0.000 claims description 4
- 238000009474 hot melt extrusion Methods 0.000 claims description 3
- 238000002844 melting Methods 0.000 claims description 3
- 230000008018 melting Effects 0.000 claims description 3
- 239000011265 semifinished product Substances 0.000 claims description 3
- 239000002904 solvent Substances 0.000 claims description 3
- 239000007921 spray Substances 0.000 claims description 3
- 238000005507 spraying Methods 0.000 claims description 3
- 206010061218 Inflammation Diseases 0.000 abstract description 7
- 230000004054 inflammatory process Effects 0.000 abstract description 7
- 230000036571 hydration Effects 0.000 abstract description 4
- 238000006703 hydration reaction Methods 0.000 abstract description 4
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 3
- 229910017052 cobalt Inorganic materials 0.000 abstract description 3
- 239000010941 cobalt Substances 0.000 abstract description 3
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 abstract description 3
- 230000007547 defect Effects 0.000 abstract description 3
- 229910017053 inorganic salt Inorganic materials 0.000 abstract description 3
- 230000035699 permeability Effects 0.000 abstract description 3
- 230000009286 beneficial effect Effects 0.000 description 7
- 230000000694 effects Effects 0.000 description 5
- 208000003556 Dry Eye Syndromes Diseases 0.000 description 4
- 206010013774 Dry eye Diseases 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 238000012377 drug delivery Methods 0.000 description 4
- 239000012528 membrane Substances 0.000 description 4
- 239000002202 Polyethylene glycol Substances 0.000 description 3
- 230000006837 decompression Effects 0.000 description 3
- 229920001223 polyethylene glycol Polymers 0.000 description 3
- 238000003825 pressing Methods 0.000 description 3
- 230000028327 secretion Effects 0.000 description 3
- 206010006784 Burning sensation Diseases 0.000 description 2
- 206010034960 Photophobia Diseases 0.000 description 2
- 230000004438 eyesight Effects 0.000 description 2
- 210000003128 head Anatomy 0.000 description 2
- 238000002513 implantation Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 229940126589 solid medicine Drugs 0.000 description 2
- GODZNYBQGNSJJN-UHFFFAOYSA-N 1-aminoethane-1,2-diol Chemical compound NC(O)CO GODZNYBQGNSJJN-UHFFFAOYSA-N 0.000 description 1
- 206010052140 Eye pruritus Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 206010061549 Sensation of foreign body Diseases 0.000 description 1
- 206010047513 Vision blurred Diseases 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000030533 eye disease Diseases 0.000 description 1
- 230000000544 hyperemic effect Effects 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 230000011514 reflex Effects 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000003867 tiredness Effects 0.000 description 1
- 208000016255 tiredness Diseases 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/00772—Apparatus for restoration of tear ducts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
- A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B9/00—Spraying apparatus for discharge of liquids or other fluent material, without essentially mixing with gas or vapour
- B05B9/03—Spraying apparatus for discharge of liquids or other fluent material, without essentially mixing with gas or vapour characterised by means for supplying liquid or other fluent material
- B05B9/04—Spraying apparatus for discharge of liquids or other fluent material, without essentially mixing with gas or vapour characterised by means for supplying liquid or other fluent material with pressurised or compressible container; with pump
- B05B9/047—Spraying apparatus for discharge of liquids or other fluent material, without essentially mixing with gas or vapour characterised by means for supplying liquid or other fluent material with pressurised or compressible container; with pump supply being effected by follower in container, e.g. membrane or floating piston, or by deformation of container
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D1/00—Processes for applying liquids or other fluent materials
- B05D1/02—Processes for applying liquids or other fluent materials performed by spraying
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D3/00—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials
- B05D3/007—After-treatment
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D3/00—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials
- B05D3/04—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by exposure to gases
- B05D3/0406—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by exposure to gases the gas being air
- B05D3/0413—Heating with air
Landscapes
- Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Plastic & Reconstructive Surgery (AREA)
- Surgery (AREA)
- Medicinal Preparation (AREA)
- Prostheses (AREA)
Abstract
The invention provides a punctal plug with an adhesive coating, comprising: the punctal plugs are coated with an adhesive layer. The inorganic salt with slightly higher permeability is added into the adhesion layer to improve the hydration speed of the adhesion layer, so that the adhesion force is generated rapidly, and the falling off or the untight blockage is prevented; antibacterial substances are added into the adhesion layer to solve the defect that lacrimal passage plugs produce lacrimal passage inflammation in the using process; the adhesive layer is added with fluorescent indicating substances, so that a doctor can observe whether the punctal plug is in place or not by cobalt blue light.
Description
Technical Field
The invention belongs to the technical field of medical treatment, and particularly relates to a punctal plug with an adhesive coating and a manufacturing process thereof.
Background
Dry eye refers to a lacrimal secretion disorder eye disease, which is caused by various factors and is mainly manifested by dry eyes, and is often accompanied by itching, foreign body sensation, burning sensation of eyes, photophobia, blurred vision, vision fluctuation, and the like. Common symptoms include dry eyes, easy tiredness, itching eyes, feeling of foreign body, pain and burning sensation, sticky secretion, fear of wind, photophobia and sensitivity to external stimuli; sometimes the eyes are too dry, the basic tears are insufficient, instead, reflex tear secretion is stimulated, and frequent tearing is caused; the eyes are red, swollen, hyperemic, keratinized, broken and adhered with filiform substances, and the damage can cause keratoconjunctival lesions and affect the eyesight after a long time. The punctal plugs are placed in the lacrimal passage to preserve natural tears secreted by the patient himself, so that the retention time of the natural tears on the surface of the eyes is prolonged, and the punctal plugs are a main means for treating moderately severe dry eyes. At present
In one study involving 93 eyes of 47 patients, the spontaneous loss rate was 14.7% after 3 months and 27.3% after 1 year and 36.8% after 2 years after implantation, and another clinical study found that the tear tap lost 47% at 6 months after implantation, most of which was lost in the first 3 months. The FCI plug of another company had a lower loss rate of 16% at 48 days and 42% at 55 days.
In order to solve the problem of loose and untight dropping and blockage, the surface of the punctal plug is coated with an adhesive material, and the coating can effectively solve the problem.
Disclosure of Invention
Therefore, the invention aims to solve the problems of falling off or untight blockage of the punctal plugs in the prior art.
The technical scheme adopted is that the punctal plug with the adhesive coating comprises: and the punctal plugs are wrapped with the adhesive layers.
Preferably, the punctal plug is cylindrical, an opening is formed in one end or two ends of the adhesion layer, and an osmotic pump layer is arranged on the adhesion layer.
Preferably, the elastic fixing device is further included, and the elastic fixing device includes: the first annular air bag, the second annular air bag, the piston and the sliding block,
a first annular air bag and a second annular air bag are arranged on the outer wall of the adhesion layer at intervals, a cavity extending along the length direction is arranged in the punctal plug, one end of a first connecting hole is communicated with the cavity, the other end of the first connecting hole is communicated with the first annular air bag, one end of a second connecting hole is communicated with the cavity, and the other end of the second connecting hole is communicated with the second annular air bag;
the novel sliding block is characterized in that a piston is arranged in the cavity, the outer wall of the piston is tightly attached to the inner wall of the cavity, the piston can reciprocate in the cavity, sliding grooves extending along the length direction are formed in the two side walls of the cavity, the sliding grooves are located between the first connecting holes and the second connecting holes, sliding blocks are arranged on the outer wall of the piston, and the sliding blocks can reciprocate in the sliding grooves.
Preferably, the device further comprises a driving device, the driving device comprises: a first air pipe, a hose, a shell, a second air pipe,
The novel lacrimal plug is characterized in that one end of the punctal plug is provided with a first air pipe, one end of the first air pipe is communicated with the cavity, the other end of the first air pipe extends out of the adhesion layer and is communicated with one end of a hose, a second air pipe is arranged on the shell, one end of the second air pipe is communicated with the other end of the hose, an annular elastic belt is arranged on the outer wall of the shell, the top of the inner wall of the shell is respectively provided with a cylinder body and an air cylinder, the top of the cylinder body is communicated with the other end of the second air pipe, a sealing plug is arranged in the cylinder body and can reciprocate in the cylinder body, the sealing plug is connected with one end of a first connecting column, the other end of the first connecting column extends below the cylinder body, a first rack in the vertical direction is arranged on the left side of the bottom of the first connecting column, and a second rack in the vertical direction is arranged on the right side of the bottom of the first connecting column;
a fixing rod in the vertical direction is arranged on the inner wall of the shell, a third rack in the vertical direction is arranged on the fixing rod, a moving block is connected to the fixing rod in a sliding manner, the moving block can slide up and down along the fixing rod in a reciprocating manner, a supporting seat is arranged on the side face of the moving block, a gear is connected to the supporting seat in a rotating manner, the gear is respectively meshed with the first rack and the third rack, a piston rod of the air cylinder is downwards connected with the upper end of a fourth rack in the vertical direction, a guide rail in the vertical direction is arranged at the bottom end of the air cylinder, a sliding bar is arranged on the side face of the fourth rack, the sliding bar can slide up and down along the guide rail in a reciprocating manner, the novel swing mechanism comprises a first rack, a second rack, a third rack, a fourth rack, a swing rod, a first rotating shaft, a first motor, a second motor, a supporting block, a rotating plate, a connecting rod one end, an output shaft coaxial connection of the first motor, a first rotating shaft, a supporting block and a supporting block.
Preferably, the device further comprises a drug delivery device, the device comprising: a nozzle, a medicine supply box and a pressure pump,
the outer wall of the adhesion layer is provided with a plurality of nozzles, the bottom in the medicine supply box is provided with a pressure pump, the output end of the pressure pump is communicated with one end of a medicine delivery pipe, the other end of the medicine delivery pipe extends into the adhesion layer and is communicated with the nozzles, and the top end of the medicine supply box is provided with a medicine inlet;
the utility model discloses a medicine feeder, including the medicine feeder, the medicine feeder is provided with the slide rail of horizontal direction, the both ends of slide rail respectively with medicine feeder inner wall connection, be provided with the guide block on the slide rail, the guide block can be in reciprocating sliding about in the slide rail, the department is provided with the bracing piece of vertical direction in the middle of the top of slide rail, be provided with the second motor on the inner wall of medicine feeder, the output shaft and the second pivot one end coaxial coupling of second motor, the second pivot other end passes the bracing piece is connected with crank one end, the second pivot with the bracing piece rotates to be connected, the upper end of bracing piece rotates and is connected with the sliding sleeve, and the crank other end is articulated with rocker one end, and the rocker other end passes the sliding sleeve is articulated with the movable rod one end of vertical direction, and the guide block is worn to the movable rod other end and is connected with the clamp plate, the movable rod can be along the up-down reciprocating motion of guide block, the clamp plate can with the inner wall bottom surface of medicine feeder contacts.
A manufacturing process of a punctal plug with an adhesive coating is suitable for the punctal plug with the adhesive coating, and comprises the following steps:
step 1, dissolving or melting an adhesion layer material through a solvent;
and 2, coating an adhesive layer on the punctal plug, and drying the punctal plug.
Preferably, in the step 2, a plurality of punctal plugs are added into the dissolved or melted adhesive material, and under the condition of continuous stirring, the material is firstly dried at a low temperature of 30-50 ℃ for the first time, and the drying method is a low-temperature normal-pressure drying method or a low-temperature reduced-pressure drying method or a freeze drying method, and then is dried at a temperature of 51-60 ℃ for the second time.
Preferably, in the step 2, the dissolved adhesive material is sprayed on the surface of the punctal plug by a spray gun, and at the same time, the surface of the punctal plug is dried by hot air at a temperature not higher than 60 ℃, and the surface can be sprayed for multiple times, and after the spraying is finished, the surface is dried by a low-temperature normal-pressure drying method or a low-temperature decompression drying method or a freeze drying method at a temperature of 30-50 ℃, and then is dried for the second time by adopting a high temperature at a temperature not higher than 60 ℃.
Preferably, in the step 2, after extruding the molding section of the punctal plug by a hot-melt extrusion method, a molten adhesive layer material is added, and the material is uniformly coated on the surface of the extruded punctal plug semi-finished product, and then dried.
Preferably, in the step 1, the adhesive layer material is dissolved in a solution and then mixed into an osmotic pressure regulator, wherein the osmotic pressure regulator is sodium chloride or potassium chloride or calcium chloride or zinc chloride, and then an indicator substance is added, and the indicator substance is fluorescein or trypan blue.
The technical scheme of the invention has the following advantages:
1. the invention provides a punctal plug with an adhesive coating, comprising: and the punctal plugs are wrapped with the adhesive layers. The inorganic salt with slightly higher permeability is added into the adhesive layer to improve the hydration speed of the adhesive layer, so that the adhesive force is generated rapidly, and the falling off or the blockage is prevented.
2. Antibacterial substances are added into the adhesion layer to solve the defect that lacrimal passage plugs produce lacrimal passage inflammation in the using process;
3. the adhesive layer is added with fluorescent indicating substances, so that a doctor can observe whether the punctal plug is in place or not by cobalt blue light.
Additional features and advantages of the invention will be set forth in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention. The objectives and other advantages of the invention may be realized and attained by the structure particularly pointed out in the written description and drawings.
The technical scheme of the invention is further described in detail through the drawings and the embodiments.
Drawings
The accompanying drawings are included to provide a further understanding of the invention and are incorporated in and constitute a part of this specification, illustrate the invention and together with the embodiments of the invention, serve to explain the invention. In the drawings:
FIG. 1 is a schematic diagram of the structure of the present invention;
FIG. 2 is a schematic view of an adhesive layer with one end open;
FIG. 3 is a schematic view of the structure of the adhesive layer with two openings at both ends in the present invention;
FIG. 4 is a schematic view of the structure of the fixing device of the present invention;
FIG. 5 is a schematic view of a chute and a slider according to the present invention;
FIG. 6 is a schematic view of the structure of the housing and the endless elastic belt of the present invention;
FIG. 7 is a schematic view of the structure of the driving device in the housing of the present invention;
FIG. 8 is a schematic diagram of the structure of the swing link, the first tooth block and the second tooth block according to the present invention;
FIG. 9 is a schematic diagram of a first motor and support block according to the present invention;
FIG. 10 is a schematic view of the structure of the drug delivery device of the present invention;
FIG. 11 is a schematic view of the construction of the pulverizing and stirring assembly of the present invention;
FIG. 12 is a schematic diagram of a second motor and a second shaft according to the present invention;
the drug delivery device comprises a 1-punctal plug, a 2-adhesive layer, a 3-first annular air bag, a 4-cavity, a 5-first connecting hole, a 6-second connecting hole, a 7-piston, an 8-sliding groove, a 9-sliding block, a 10-second annular air bag, an 11-first air pipe, a 12-hose, a 13-shell, a 14-second air pipe, a 15-sliding sleeve, a 16-annular elastic band, a 17-cylinder, a 18-cylinder, a 19-sealing plug, a 20-first connecting column, a 21-first rack, a 22-second rack, a 23-fixed rod, a 24-third rack, a 25-movable block, a 26-supporting seat, a 27-gear, a 28-piston rod, a 29-fourth rack, a 30-guide rail, a 31-sliding bar, a 32-swinging rod, a 33-first tooth block, a 34-second tooth block, a 35-rotating plate, a 36-connecting rod, a 37-first rotating shaft, a 38-first motor, a 39-supporting block, a 40-nozzle, a 41-feeding box, a 42-pressure pump, a 43-drug inlet, a 44-sliding rail, a 45-guiding block, a 46-second guide block, a 48-crank, a 48-second rotating shaft, a 48-rotating rod, a 53-crank and a pressure plate.
Detailed Description
In order to make the technical problems, technical schemes and beneficial effects to be solved more clear, the invention is further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the scope of the invention.
It will be understood that when an element is referred to as being "mounted" or "disposed" on another element, it can be directly on the other element or be indirectly on the other element. When an element is referred to as being "connected to" another element, it can be directly or indirectly connected to the other element.
It is to be understood that the terms "length," "width," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like are merely for convenience in describing and simplifying the description based on the orientation or positional relationship shown in the drawings, and do not indicate or imply that the devices or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus are not to be construed as limiting the invention.
Furthermore, the terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include one or more such feature. In the description of the present invention, the meaning of "a plurality" is two or more, unless explicitly defined otherwise.
A punctal plug with an adherent coating of the invention, as shown in fig. 1, comprises: a punctal plug 1 and an adhesive layer 2, wherein the punctal plug 1 is wrapped with the adhesive layer 2.
The technical scheme has the working principle and beneficial technical effects that: since in: the outer layer of the punctal plug 1 is added with an adhesive layer 2, and the punctal plug is implanted into the lacrimal passage, and the adhesive layer can accelerate hydration, quickly generate adhesion force and prevent falling off or untight blockage. The adhesion layer is also added with a bacteriostat to reduce inflammation generated in the use process. The adhesive material is as follows: alpha, omega diamino polyethylene glycol with molecular weight of 10kDa, 20kDa, 40kDa, eight-arm polyethylene glycol amine with molecular weight of 10kDa, 20kDa, 40DaK, other proper polyethylene glycol polymer or other pharmaceutically usable high molecular compound.
In one embodiment, as shown in fig. 2-3, the punctal plug 1 is cylindrical, and one end of the adhesion layer 2 is provided with an opening or both ends are provided with openings, so that the use of the adhesion layer material is reduced by providing an open end, and the cost is saved. The adhesion layer 2 is provided with an osmotic pump layer, the osmotic pump layer is formed by wrapping a semipermeable coating film formed by a layer of polymer on an osmotic pump core, and one or a plurality of drug release pores with proper size are formed on the coating film layer by laser. After the punctal plug 1 is placed in the lacrimal passage, tears pass through the semipermeable membrane and enter the pump core, the osmotic pressure active substance makes the solution in the membrane be hypertonic, and the osmotic pressure existing inside and outside the membrane makes water continuously enter the membrane, so that the drug solution or suspended drug is continuously fed from the small Kong Bengchu, and the punctal plug is prevented from causing inflammation.
In one embodiment, as shown in fig. 4, further comprising an elastic fixing device, the elastic fixing device comprising: a first annular air bag 3, a second annular air bag 10, a piston 7 and a sliding block 9,
a first annular air bag 3 and a second annular air bag 10 are arranged on the outer wall of the adhesion layer 2 at intervals, a cavity 4 extending along the length direction is arranged in the punctal plug 1, one end of a first connecting hole 5 is communicated with the cavity 4, the other end of the first connecting hole 5 is communicated with the first annular air bag 3, one end of a second connecting hole 6 is communicated with the cavity 4, and the other end of the second connecting hole 6 is communicated with the second annular air bag 10;
the novel sliding block type air conditioner is characterized in that a piston 7 is arranged in the cavity 4, the outer wall of the piston 7 is tightly attached to the inner wall of the cavity 4, the piston 7 can reciprocate in the cavity 4, sliding grooves 8 extending in the length direction are formed in the two side walls of the cavity 4, the sliding grooves 8 are located between the first connecting holes 5 and the second connecting holes 6, sliding blocks 9 are arranged on the outer wall of the piston 7, and the sliding blocks 9 can reciprocate in the sliding grooves 8.
The technical scheme has the working principle and beneficial technical effects that: in the process of shaking the head, the piston 7 reciprocates in the cavity 4, so that the first annular air bag 3 and the second annular air bag 10 are alternately inflated, the punctal plug can be fixed in the lacrimal passage, and simultaneously, the air bags are alternately inflated, thereby being beneficial to massaging different parts of the lacrimal passage, accelerating blood circulation and reducing the problem that local fixation is easy to cause inflammation
In one embodiment, as shown in fig. 4-9, further comprising a drive device, the drive device comprising: a first air pipe 11, a hose 12, a shell 13, a second air pipe 14,
One end of the punctal plug 1 is provided with a first air pipe 11, one end of the first air pipe 11 is communicated with the cavity 4, the other end of the first air pipe 11 extends out of the adhesive layer 2 and is communicated with one end of a hose 12, a shell 13 is provided with a second air pipe 14, one end of the second air pipe 14 is communicated with the other end of the hose 12, the outer wall of the shell 13 is provided with an annular elastic belt 16, the top of the inner wall of the shell 13 is respectively provided with a cylinder 17 and a cylinder 18, the top of the cylinder 17 is communicated with the other end of the second air pipe 14, a sealing plug 19 is arranged in the cylinder 17, the sealing plug 19 can reciprocate in the cylinder 17, the sealing plug 19 is connected with one end of a first connecting column 20, the other end of the first connecting column 20 extends below the cylinder 17, the left side of the bottom end of the first connecting column 20 is provided with a first rack 21 in the vertical direction, and the right side of the bottom of the first connecting column 20 is provided with a second rack 22 in the vertical direction;
a fixing rod 23 in the vertical direction is arranged on the inner wall of the shell 13, a third rack 24 in the vertical direction is arranged on the fixing rod 23, a moving block 25 is slidably connected to the fixing rod 23, the moving block 25 can slide up and down along the fixing rod 23, a supporting seat 26 is arranged on the side surface of the moving block 25, a gear 27 is rotatably connected to the supporting seat 26, the gear 27 is respectively meshed with the first rack 21 and the third rack 24, a piston rod 28 of the air cylinder 18 is connected with the upper end of a fourth rack 29 in the vertical direction downwards, a guide rail 30 in the vertical direction is arranged at the bottom end of the air cylinder 18, a sliding bar 31 is arranged on the side surface of the fourth rack 29, the sliding bar 31 can slide up and down along the guide rail 30, the swing rod 32 is arranged between the second rack 22 and the fourth rack 29, the left end of the swing rod 32 is provided with the first tooth block 33, the first tooth block 33 is meshed with the second rack 22, the right end of the swing rod 32 is provided with the second tooth block 34, the second tooth block 34 is meshed with the fourth rack 29, a rotating plate 35 is arranged below the swing rod 32, one end of a connecting rod 36 is hinged with the middle of the swing rod 32, the other end of the connecting rod 36 is hinged with the eccentric position of the rotating plate 35, one end of a first rotating shaft 37 is coaxially connected with the rotating plate 35, the other end of the first rotating shaft 37 is coaxially connected with an output shaft of a first motor 38, the first motor 38 is mounted on the inner wall of the shell 13, the first rotating shaft 37 penetrates through a supporting block 39 and is rotationally connected with the supporting block 39, and the supporting block 39 is fixedly connected with the inner wall of the shell 13.
The technical scheme has the working principle and beneficial technical effects that: the annular elastic belt 16 can be arranged on the head, the first motor 38 is started, the first rotating shaft 37 drives the rotating plate 35 to rotate, the rotating plate 35 drives the connecting rod 36 to move up and down, the swing rod 32 takes the meshing of the second tooth block 34 and the fourth tooth bar 29 as a fulcrum, the first tooth block 33 is driven to reciprocate up and down, the second tooth bar 22 is driven to reciprocate up and down through the meshing of the first tooth block 33 and the second tooth bar 22, the gear 27 is respectively meshed with the first tooth bar 21 and the third tooth bar 24, the guiding and supporting effects are achieved, the second tooth bar 22 drives the first connecting column 20 and the sealing plug 19 to reciprocate up and down, the volume in the cylinder 17 is changed continuously, and the first annular air bag 3 and the second annular air bag 10 are inflated or sucked through the second air pipe 14, the hose 12 and the first air pipe 11 to the cavity 4, so that the adjustment of the tension degree is met. When the cylinder 18 is started, the fourth rack 29 is driven to move up and down, the position of the fourth rack 29 is adjusted, correspondingly, the position of the engagement point between the second tooth block 34 and the fourth rack 29 is changed, the up-and-down movement amplitude of the first tooth block 33 is changed, and the up-and-down movement amplitude of the corresponding sealing plug 19 is changed, so that the maximum tension of the first annular air bag 3 and the second annular air bag 10 can be adjusted, and the requirement of patients on the tension under different conditions is met.
In one embodiment, as shown in fig. 10-12, further comprising a drug delivery device comprising: a nozzle 40, a medicine feed box 41 and a pressure pump 42,
a plurality of nozzles 40 are arranged on the outer wall of the adhesion layer 2, a pressure pump 42 is arranged at the bottom in the medicine feeding box 41, the output end of the pressure pump 42 is communicated with one end of a medicine delivery pipe 53, the other end of the medicine delivery pipe 53 extends into the adhesion layer 2 and is communicated with each nozzle 40, and a medicine inlet 43 is arranged at the top end of the medicine feeding box 41;
the utility model discloses a medicine feeder, including medicine feeder 41, slide rail 44 is last to be provided with guide block 45 respectively with medicine feeder 41 inner wall connection, guide block 45 can be in slide rail 44 is inside left and right sides reciprocal slip, the top intermediate position of slide rail 44 is provided with vertical direction's bracing piece 46, be provided with second motor 47 on the inner wall of medicine feeder 41, the output shaft of second motor 47 and second pivot 48 one end coaxial coupling, the second pivot 48 other end passes bracing piece 46 and crank 49 one end are connected, second pivot 48 with bracing piece 46 rotates to be connected, the upper end of bracing piece 46 rotates to be connected with sliding sleeve 15, the crank 49 other end is articulated with rocker 50 one end, the rocker 50 other end passes sliding sleeve 15 is articulated with vertical direction's movable rod 51 one end, the guide block 45 is worn to the movable rod 51 other end and is connected with clamp plate 52, movable rod 51 can reciprocate along guide block 45, clamp plate 52 can with the inner wall bottom surface of medicine feeder 41 contacts.
The technical scheme has the working principle and beneficial technical effects that: the solid medicine particles and the solution are put into the medicine feeding port 43, the second motor 47 is started to drive the second rotating shaft 48 and the crank 49 to rotate, the crank 49 drives the rocker 50 to reciprocate in the sliding sleeve 15, the rocker 50 swings around the sliding sleeve 15, the rocker 50 drives the moving rod 51 to move, the moving rod 51 is restrained by the guide block 45 and can only move along the horizontal direction and the vertical direction, the pressing plate 52 moves downwards along the arc line through the composite superposition of the movement, then the pressing plate 52 contacts the bottom surface of the inner wall of the medicine feeding box 41, after crushing the solid medicine particles, a certain distance is further carried out, the pressing plate 52 is lifted up and returns to the initial position along the arc line, so that the medicine liquid is crushed while stirring, and after being uniformly mixed, the medicine liquid is driven by the pressure pump 42 and finally sprayed to an affected part through the medicine conveying pipe 53 and the nozzle 40, and inflammation is treated.
In one embodiment, a process for making a punctal plug with an adherent coating, suitable for use with the punctal plug with an adherent coating, comprises the steps of:
step 1, dissolving or melting an adhesion layer material through a solvent;
and 2, coating an adhesive layer on the punctal plug, and drying the punctal plug.
In the step 2, a plurality of punctal plugs are added into the dissolved or melted adhesive material, and under the condition of continuous stirring, the material is firstly dried at the low temperature of 30-50 ℃ for the first time, the drying method is a low-temperature normal-pressure drying method or a low-temperature decompression drying method or a freeze drying method, and then is dried at the temperature of 51-60 ℃ for the second time.
In the step 2, the dissolved adhesive material is sprayed on the surface of the punctal plug by a spray gun, and at the same time, the surface of the punctal plug is dried by hot air at the temperature of not higher than 60 ℃ and can be sprayed for multiple times, after the spraying is finished, the surface of the punctal plug is dried by a low-temperature normal-pressure drying method or a low-temperature decompression drying method or a freeze drying method at the temperature of 30-50 ℃, and then the surface of the punctal plug is dried for the second time by adopting the high temperature at the temperature of not higher than 60 ℃ so as to ensure that the moisture of the adhesive layer is fully volatilized, and the moisture residue is lower than 0.1-0.001%. The weight gain of the adhesion layer is 0.1-50%.
In step 2, the coating method may also be a coextrusion method, in which a molten adhesive layer material is added after extruding the shaped section of the punctal plug by hot melt extrusion, and the material is uniformly coated on the surface of the extruded punctal plug semi-finished product, and then dried. The coating method does not need secondary drying, and the process is simple.
In the step 1, the adhesive layer material is dissolved in a solution and then mixed into an osmotic pressure regulator, wherein the osmotic pressure regulator is sodium chloride or potassium chloride or calcium chloride or zinc chloride, and then an indicator substance is added, and the indicator substance is fluorescein or trypan blue. After the adhesive layer material is dissolved by the solution, adding an osmotic pressure regulator, wherein the osmotic pressure regulator is sodium chloride or potassium chloride or calcium chloride or zinc chloride or other pharmaceutically acceptable osmotic pressure regulator, and then adding an indicating substance, wherein the indicating substance is fluorescein or trypan blue.
The technical scheme has the working principle and beneficial technical effects that: after the lacrimal passage is implanted, the lacrimal plug can be adhered in the lacrimal passage, so that the problem of falling off in clinical use is solved; the inorganic salt with slightly higher permeability is added into the adhesion layer to improve the hydration speed of the adhesion layer; antibacterial substances are added into the adhesion layer to solve the defect that lacrimal passage plugs produce lacrimal passage inflammation in the using process; the adhesive layer is added with fluorescent indicating substances, so that a doctor can observe whether the punctal plug is in place or not by cobalt blue light.
It will be apparent to those skilled in the art that various modifications and variations can be made to the present invention without departing from the spirit or scope of the invention. Thus, it is intended that the present invention also include such modifications and alterations insofar as they come within the scope of the appended claims or the equivalents thereof.
Claims (9)
1. A punctal plug with an adherent coating, comprising: a punctal plug (1) and an adhesive layer (2), wherein the punctal plug (1) is wrapped with the adhesive layer (2);
still include elastic fixation device, elastic fixation device includes: the first annular air bag (3), the second annular air bag (10), the piston (7) and the sliding block (9),
a first annular air bag (3) and a second annular air bag (10) are arranged on the outer wall of the adhesion layer (2) at intervals, a cavity (4) extending along the length direction is arranged in the punctal plug (1), one end of a first connecting hole (5) is communicated with the cavity (4), the other end of the first connecting hole (5) is communicated with the first annular air bag (3), one end of a second connecting hole (6) is communicated with the cavity (4), and the other end of the second connecting hole (6) is communicated with the second annular air bag (10);
be provided with piston (7) in cavity (4), the outer wall of piston (7) with cavity (4) inner wall is hugged closely, piston (7) can be in reciprocating motion in cavity (4), be provided with spout (8) along length direction extension on the both sides wall of cavity (4), spout (8) are located between first connecting hole (5) and second connecting hole (6), be provided with slider (9) on the outer wall of piston (7), slider (9) can reciprocating motion in spout (8).
2. The punctal plug with the adhesive coating according to claim 1, characterized in that the punctal plug (1) is cylindrical, one end of the adhesive layer (2) is provided with an opening or two ends are provided with openings, and an osmotic pump layer is arranged on the adhesive layer (2).
3. The adhesive coated punctal plug of claim 1, further comprising a drive means, the drive means comprising: a first air pipe (11), a hose (12), a shell (13) and a second air pipe (14),
one end of the punctal plug (1) is provided with a first air pipe (11), one end of the first air pipe (11) is communicated with the cavity (4), the other end of the first air pipe (11) extends to the outside of the adhesion layer (2) and is communicated with one end of the hose (12), a second air pipe (14) is arranged on the shell (13), one end of the second air pipe (14) is communicated with the other end of the hose (12), an annular elastic belt (16) is arranged on the outer wall of the shell (13), cylinder bodies (17) and cylinder bodies (18) are respectively arranged at the top of the inner wall of the shell (13), the top ends of the cylinder bodies (17) are communicated with the other end of the second air pipe (14), sealing plugs (19) are arranged in the cylinder bodies (17), the sealing plugs (19) can reciprocate in the cylinder bodies (17), one ends of the sealing plugs (19) are connected with one ends of the first connecting columns (20), the other ends of the first connecting columns (20) extend to the lower parts of the cylinder bodies (17), the left sides of the bottom ends of the first connecting columns (20) are provided with first racks (21) in the vertical directions, and the right sides of the first racks (20) are provided with first racks (22) in the vertical directions;
a fixing rod (23) in the vertical direction is arranged on the inner wall of the shell (13), a third rack (24) in the vertical direction is arranged on the fixing rod (23), a moving block (25) is slidably connected to the fixing rod (23), the moving block (25) can slide up and down along the fixing rod (23), a supporting seat (26) is arranged on the side surface of the moving block (25), a gear (27) is rotationally connected to the supporting seat (26), the gear (27) is respectively meshed with the first rack (21) and the third rack (24), a piston rod (28) of the cylinder (18) is downwards connected with the upper end of a fourth rack (29) in the vertical direction, the bottom end of the air cylinder (18) is provided with a guide rail (30) in the vertical direction, the side surface of the fourth rack (29) is provided with a slide bar (31), the slide bar (31) can slide up and down along the guide rail (30), a swing rod (32) is arranged between the second rack (22) and the fourth rack (29), the left end of the swing rod (32) is provided with a first tooth block (33), the first tooth block (33) is meshed with the second rack (22), the right end of the swing rod (32) is provided with a second tooth block (34), the second tooth block (34) is meshed with the fourth rack (29), the lower part of pendulum rod (32) is provided with swivel plate (35), connecting rod (36) one end with the centre department of pendulum rod (32) articulates, and connecting rod (36) other end is articulated with the eccentric department of swivel plate (35), first pivot (37) one end with swivel plate (35) coaxial coupling, first pivot (37) other end and the output shaft coaxial coupling of first motor (38), first motor (38) are installed on casing (13) inner wall, first pivot (37) pass supporting shoe (39), and with supporting shoe (39) rotate to be connected, supporting shoe (39) with casing (13) inner wall fixed connection.
4. The adhesive coated punctal plug of claim 1, further comprising an administration device, the administration device comprising: a nozzle (40), a medicine supply box (41) and a pressure pump (42),
a plurality of nozzles (40) are arranged on the outer wall of the adhesion layer (2), a pressure pump (42) is arranged at the inner bottom of the medicine supply box (41), the output end of the pressure pump (42) is communicated with one end of a medicine delivery pipe (53), the other end of the medicine delivery pipe (53) extends into the adhesion layer (2) and is communicated with each nozzle (40), and a medicine inlet (43) is formed at the top end of the medicine supply box (41);
the utility model discloses a medicine feeding box, including medicine feeding box (41), slide rail (44) of horizontal direction set up in medicine feeding box (41), both ends of slide rail (44) respectively with medicine feeding box (41) inner wall connection, be provided with guide block (45) on slide rail (44), guide block (45) can be in reciprocating sliding about in slide rail (44), the department is provided with bracing piece (46) of vertical direction in the middle of the top of slide rail (44), be provided with second motor (47) on medicine feeding box (41)'s the inner wall, the output shaft and second pivot (48) one end coaxial coupling of second motor (47), the second pivot (48) other end pass bracing piece (46) are connected with crank (49) one end, second pivot (48) with bracing piece (46) rotate and are connected, upper end rotation of bracing piece (46) is connected with sliding sleeve (15), and crank (49) other end and rocker (50) one end are articulated, and rocker (50) other end are worn by sliding sleeve (15) and vertical direction's movable rod (51) one end are articulated, movable rod (51) other end and second pivot (48) other end pass guide block (52) and are connected with medicine feeding box (52) can be followed in a reciprocating motion.
5. A process for making a punctal plug with an adherent coating, suitable for use in a punctal plug with an adherent coating according to any one of claims 1 to 4, comprising the steps of:
step 1, dissolving or melting an adhesion layer material through a solvent;
and 2, coating an adhesive layer on the punctal plug, and drying the punctal plug.
6. The process of claim 5, wherein in step 2, a plurality of punctal plugs are added into the dissolved or melted adhesive material, and the material is dried at a low temperature of 30-50 ℃ for the first time under continuous stirring, and the drying method is a low temperature normal pressure drying method, a low temperature reduced pressure drying method or a freeze drying method, and then dried at a temperature of 51-60 ℃ for the second time.
7. The process of claim 5, wherein in step 2, the dissolved adhesive material is sprayed on the surface of the punctal plug by a spray gun, and the punctal plug is dried by hot air at a temperature not higher than 60 ℃ and sprayed for multiple times, and after spraying, the punctal plug is dried by a low-temperature normal-pressure drying method or a low-temperature reduced-pressure drying method or freeze drying method at 30-50 ℃ and then is dried for a second time by a high temperature not higher than 60 ℃.
8. The process of claim 5, wherein in step 2, after extruding the shaped section of the punctal plug by hot melt extrusion, a molten adhesive layer material is added, and the material is uniformly coated on the surface of the extruded punctal plug semi-finished product, and then dried.
9. The process of claim 5, wherein in step 1, the adhesive layer material is dissolved in a solution and mixed with an osmotic pressure regulator, the osmotic pressure regulator is sodium chloride or potassium chloride or calcium chloride or zinc chloride, and then an indicator substance is added, the indicator substance is fluorescein or trypan blue.
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| CN202110900863.4A CN113616414B (en) | 2021-08-06 | 2021-08-06 | Punctal plug with adhesive coating and manufacturing process thereof |
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| CN103300968A (en) * | 2012-02-28 | 2013-09-18 | 庄臣及庄臣视力保护公司 | Balloon punctal plug |
| CN107949354A (en) * | 2015-07-22 | 2018-04-20 | 因赛普特有限责任公司 | The Punctal plug of coating |
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| WO2009079559A1 (en) * | 2007-12-17 | 2009-06-25 | University Of Florida Research Foundation, Inc. | Dry eye treatment by puncta plugs |
| US20110251568A1 (en) * | 2010-04-08 | 2011-10-13 | Beeley Nathan R F | Punctal plugs for controlled release of therapeutic agents |
| US11458041B2 (en) * | 2015-10-08 | 2022-10-04 | Ocular Therapeutix, Inc. | Punctal plug and bioadhesives |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103300968A (en) * | 2012-02-28 | 2013-09-18 | 庄臣及庄臣视力保护公司 | Balloon punctal plug |
| CN107949354A (en) * | 2015-07-22 | 2018-04-20 | 因赛普特有限责任公司 | The Punctal plug of coating |
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