CN113614223B - 获得诱导性平滑肌细胞的方法 - Google Patents

获得诱导性平滑肌细胞的方法 Download PDF

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CN113614223B
CN113614223B CN202080021489.4A CN202080021489A CN113614223B CN 113614223 B CN113614223 B CN 113614223B CN 202080021489 A CN202080021489 A CN 202080021489A CN 113614223 B CN113614223 B CN 113614223B
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cells
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smooth muscle
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CN113614223A (zh
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M.瑟纳
R.马克斯坦纳
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Inova Cell Co ltd
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0661—Smooth muscle cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/34—Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/15—Transforming growth factor beta (TGF-β)
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/90—Polysaccharides
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1323—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from skeletal muscle cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2513/00—3D culture

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  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
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CN202080021489.4A 2019-03-22 2020-03-23 获得诱导性平滑肌细胞的方法 Active CN113614223B (zh)

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EP19164574.6 2019-03-22
EP19164574 2019-03-22
PCT/EP2020/057940 WO2020193460A1 (en) 2019-03-22 2020-03-23 Methods for obtaining induced smooth muscle cells

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KR102780297B1 (ko) 2017-12-14 2025-03-12 이노바셀 바이오테크놀로지 아게 근육 유래 세포를 수득하는 방법
KR20220002315A (ko) 2019-03-22 2022-01-06 이노바셀 아게 유도된 평활근 세포를 수득하는 방법
EP4741009A3 (en) 2021-08-06 2026-08-12 Innovacell GmbH Myogenic progenitor cells for use in an optimized method for the prevention and treatment of anal incontinence

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US8211423B2 (en) * 2006-11-28 2012-07-03 University Of Pittsburgh Muscle derived cells for the treatment of cardiac pathologies and methods of making and using the same
US6555374B1 (en) * 1999-08-19 2003-04-29 Artecel Sciences, Inc. Multiple mesodermal lineage differentiation potentials for adipose tissue-derived stromal cells and uses thereof
AU5159901A (en) 2000-04-14 2001-10-30 Univ Pittsburgh Soft tissue and bone augmentation and bulking utilizing muscle-derived progenitor cells, compositions and treatments thereof
JPWO2003027281A1 (ja) 2001-09-20 2005-01-06 協和醗酵工業株式会社 骨格筋間質由来多分化能幹細胞
ATE482713T1 (de) 2003-04-25 2010-10-15 Univ Pittsburgh Von muskeln stammende zellen (mdcs) zur förderung und verbesserung der nervenreparatur und - regeneration
WO2007010858A1 (ja) * 2005-07-15 2007-01-25 Kyoto University 骨格筋組織由来の単一細胞よりクローン化した多能性幹細胞
FR2890977A1 (fr) 2005-09-19 2007-03-23 Assist Publ Hopitaux De Paris Procede d'obtention de cellules musculaires lisses humaines et leurs applications
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KR20220002315A (ko) 2019-03-22 2022-01-06 이노바셀 아게 유도된 평활근 세포를 수득하는 방법
EP4741009A3 (en) 2021-08-06 2026-08-12 Innovacell GmbH Myogenic progenitor cells for use in an optimized method for the prevention and treatment of anal incontinence

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WO2020193460A1 (en) 2020-10-01
JP2025011242A (ja) 2025-01-23
IL286509A (en) 2021-10-31
JP7616665B2 (ja) 2025-01-17
CL2021002169A1 (es) 2022-02-25
IL286509B1 (en) 2026-04-01
US20220145257A1 (en) 2022-05-12
DK3942020T3 (da) 2024-07-15
CN113614223A (zh) 2021-11-05
JP2022526229A (ja) 2022-05-24
EP4397752A3 (en) 2024-10-02
AU2020247211B2 (en) 2024-07-04
US20250207097A1 (en) 2025-06-26
EP3942020B1 (en) 2024-05-15
MX2021009862A (es) 2021-09-14
NZ778000A (en) 2025-07-25
CN120738111A (zh) 2025-10-03
KR20220002315A (ko) 2022-01-06
CA3134213A1 (en) 2020-10-01
ZA202104948B (en) 2024-08-28
BR112021016264A2 (pt) 2021-10-13
US12312600B2 (en) 2025-05-27
AU2020247211A1 (en) 2021-07-29
IL286509B2 (en) 2026-08-01
EP3942020A1 (en) 2022-01-26
ES2987152T3 (es) 2024-11-14
EP4397752A2 (en) 2024-07-10

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