CN113600588A - Radioactive synthesis experimental device capable of self-purifying and monitoring and experimental fume hood - Google Patents

Abstract

The application discloses a radiosynthesis experimental apparatus and an experimental fume hood that can self-purify and monitor. The radioactive synthesis experimental device comprises a device main body, a self-purification mechanism, a circulation mechanism, an exhaust mechanism and a controller. The self-purification mechanism comprises a purification body and at least one purification assembly. The purification body is provided with a purification inlet, a purification outlet and a purification cavity communicated with the purification inlet and the purification outlet. The purification inlet is communicated with the synthesis cavity. A purge assembly is disposed in the purge chamber; the circulating mechanism comprises a circulating pipeline communicated with the purification outlet and the synthesis cavity, and a radioactivity monitoring element, a filtering element and a circulating pump which are sequentially arranged in the circulating pipeline; the exhaust mechanism includes an exhaust pipe, and a control valve and an exhaust pump that are sequentially provided in the exhaust pipe. An opening of the discharge pipe is connected to the circulation pipe and interposed between the filter element and the circulation pump. The device can effectively purify radioactive dirt generated in the radioactive synthesis process.

Description

Radioactive synthesis experimental device capable of self-purifying and monitoring and experimental fume hood

Technical Field

The invention relates to the technical field of radioactive synthesis experimental equipment, in particular to a radioactive synthesis experimental device capable of self-purifying and monitoring and an experimental fume cupboard.

Background

At present, radionuclides are widely used in clinical medicine, non-clinical trials, registration and use of pesticides and chemicals, and the like, and are not only used for diagnosis and treatment of diseases, but also related to safety evaluation of mothers and metabolites thereof after pesticides, medicines and chemicals are on the market.

Therefore, the preparation and synthesis process of the radioisotope is of considerable importance.

However, the synthesis, preparation, and distribution of the radionuclide need to be performed in a fume hood with a shielding function. Most of the existing fume hoods have simple structure and single function. Due to the diversity and complexity of radioactive synthesis operation and the inconsistency of nuclide intermediate states in the synthesis process, the outflow of pollutants is difficult to control effectively, and the prevention and treatment measures of the pollutants need to be improved according to specific compounds, so that radionuclide personnel have high operation difficulty, the pollutants are not controlled completely and uniformly, and the working efficiency is low.

In addition, in the above operation process, the radioactive substance is transferred by hand, and although the radiation dose of the radioactive substance is small, the operator still receives a certain radiation dose after contacting the radioactive substance for a long time, which affects the health of the operator.

Disclosure of Invention

One advantage of the present invention is to provide a radioactive synthesis experimental apparatus capable of self-purification and monitoring, which can effectively purify contaminants generated during the synthesis of radioactive materials by a self-purification mechanism, and discharge the contaminants when the radioactivity is lower than a predetermined value, and perform cyclic purification when the radioactivity is not lower than the predetermined value, thereby effectively controlling the outflow of the radioactive contaminants, and has the advantages of simple operation and high work efficiency.

One advantage of the present invention is to provide a radiosynthesis experiment apparatus capable of self-purification and monitoring, in which an upper synthesis chamber and a lower synthesis chamber are disposed in a main body of the apparatus such that upper and lower portions thereof are communicated with each other, so that it is convenient to place various reaction vessels required for synthesis in the lower synthesis chamber, thereby facilitating a synthesis reaction in the upper synthesis chamber.

An advantage of the present invention is to provide a radiosynthesis experiment apparatus capable of self-purification and monitoring, which can further enhance the sealing performance of the apparatus main body by providing a sealing member, thereby preventing leakage of radioactive materials.

One advantage of the present invention is to provide a radiosynthesis experiment apparatus capable of self-purification and monitoring, which can form a combination with different purification functions by disposing a purification assembly, and further can purify various radioactive substances in the gas generated during the radiosynthesis experiment process, with high purification efficiency.

One advantage of the present invention is to provide a radioactive synthesis experimental apparatus capable of self-purification and monitoring, which is capable of controlling various volatile small molecule radioactive substances at low temperature by arranging a condensing assembly, and performing directional discharge and collection through a condensed gas discharge port.

One advantage of the present invention is to provide a radiosynthesis experimental apparatus capable of self-purification and monitoring, which can further purify radioactive contaminants generated by radiosynthesis by providing an adsorption module to adsorb and filter various radioactive substances.

One advantage of the present invention is to provide a radioactive synthesis experimental apparatus capable of self-purification and monitoring, which is convenient for workers to build or connect various synthesis apparatuses in a synthesis chamber without direct contact by setting glove holes and adjusting gloves, so as to avoid radiation of radioactive substances and make the use safer.

One advantage of the present invention is to provide a radiosynthesis experiment apparatus capable of self-purification and monitoring, which can effectively prevent radioactive material from leaking during a sampling process by providing a sampling cavity and a first and a second sampling gate.

One advantage of the present invention is to provide a radiosynthesis experimental apparatus capable of self-purification and monitoring, which can effectively improve the automation degree of the radiosynthesis experimental apparatus by setting a control device, and has more accurate control and higher work efficiency.

One advantage of the present invention is to provide an experimental fume hood, in which the radiosynthesis experiment apparatus is located inside the fume hood, and through linkage cooperation between the fume device and the control apparatus as well as the control valve or the exhaust pump, a suitable negative pressure environment can be provided during low-power operation, safety of the radiosynthesis experiment can be ensured, various gases generated during high-power operation can be rapidly exhausted, automation degree of the radiosynthesis experiment can be improved, energy consumption of the fume device can be greatly reduced, and cost can be reduced.

To achieve at least one of the above advantages, the present invention provides a radiosynthesis assay device that is self-cleaning and monitoring, the radiosynthesis assay device comprising:

the device comprises a device main body, a water supply device and a water supply device, wherein the device main body forms a synthesis cavity and is provided with an air inlet, an air outlet and a water supply port which are communicated with the synthesis cavity;

a self-cleaning mechanism, which comprises a cleaning body and at least one cleaning component, wherein the cleaning body has a cleaning inlet, a cleaning outlet and a cleaning chamber communicating the cleaning inlet and the cleaning outlet, the cleaning inlet communicates with the synthesis chamber, and the cleaning component is disposed in the cleaning chamber for cleaning radioactive substances in the gas;

the circulation mechanism comprises a circulation pipeline communicated with the purification outlet and the synthesis cavity, and at least one radioactivity monitoring element, at least one filtering element and at least one circulation pump which are sequentially arranged in the circulation pipeline;

the air exhaust mechanism comprises an exhaust pipeline, a control valve and at least one air exhaust pump, wherein the control valve and the air exhaust pump are sequentially arranged on the exhaust pipeline, and an opening of the exhaust pipeline is connected with the circulating pipeline and is arranged between the filter element and the circulating pump; and

a controller, said radioactivity monitoring element communicatively coupled to said controller, said circulation pump, said control valve, and said exhaust pump being controllably coupled to said controller.

According to an embodiment of the present invention, a support plate is disposed in the synthesis chamber of the apparatus main body to divide the synthesis chamber into an upper synthesis chamber and a lower synthesis chamber, wherein the support plate is provided with a mounting passage communicating the upper synthesis chamber and the lower synthesis chamber.

According to an embodiment of the present invention, the device further comprises a sealing member, wherein the sealing member is covered by the bottom of the device body and extends to the upper synthetic cavity to seal the device body.

According to an embodiment of the present invention, the purification assembly includes at least one absorption assembly, wherein the absorption assembly forms an absorption cavity, and the absorption cavity contains absorption liquid or absorption gas capable of absorbing radioactive substances in the gas.

According to an embodiment of the present invention, the purification assembly further includes at least one condensing assembly, the condensing assembly is located at an upstream or a downstream of the absorption assembly, and the condensing assembly forms a condensing chamber, the condensing chamber communicates with the purification inlet and the absorption chamber or the purification outlet and the absorption chamber, and a condensed gas outlet communicating with the condensing chamber is provided at a bottom of the condensing assembly.

According to an embodiment of the present invention, the purification assembly further comprises at least one adsorption assembly, the adsorption assembly is located between the purification inlet and the absorption assembly, or between the absorption assembly and the condensation assembly, or between the condensation assembly and the circulation mechanism, and the adsorption assembly forms an adsorption chamber, wherein the adsorption chamber communicates the purification inlet and the absorption chamber, or the absorption chamber and the condensation chamber, or the condensation chamber and the purification outlet.

According to an embodiment of the invention, the adsorption component is implemented as a molecular sieve and/or activated carbon.

According to an embodiment of the present invention, the apparatus main body is further provided with at least one glove hole communicating with the synthesis chamber, and an adjusting glove is disposed at the glove hole, wherein the adjusting glove extends toward the synthesis chamber and seals the glove hole.

According to an embodiment of the present invention, the device body is further provided with at least one sampling cavity communicated with the synthesis cavity, wherein a first sampling gate is disposed between the sampling cavity and the synthesis cavity, and a second sampling gate is disposed at a position of the sampling cavity close to a side wall of the device body.

According to an embodiment of the present invention, a predetermined value is pre-stored in the controller, the radioactivity monitoring element is communicatively connected to the controller, the control valve, the circulation pump and the exhaust pump are controllably connected to the controller, so that when the monitored value of the radioactivity monitoring element is fed back to the controller and is lower than the predetermined value, the controller can control the control valve to be opened and control the exhaust pump to operate, and when the monitored value of the radioactivity monitoring element is fed back to the controller and is not lower than the predetermined value, the controller can control the control valve to be closed and control the circulation pump to operate.

The present invention also provides an experimental fume hood, wherein the experimental fume hood comprises:

a fume hood body, wherein the fume hood body forms a fume chamber and a fume device is disposed on the fume hood body to exhaust gases from the fume chamber; and

the above self-decontaminating and monitoring radiosynthesis assay device, wherein said radiosynthesis assay device is removably disposed in said ventilation lumen;

wherein the ventilator is controllably connected to the controller such that the controller can control the ventilator to remain operating at a predetermined power when the controller monitors that the control valve is closed or the exhaust pump is not operating, and the controller can control the ventilator to remain operating at a power greater than the predetermined power when the controller monitors that the control valve is open or the exhaust pump is operating.

These and other objects, features and advantages of the present invention will become more fully apparent from the following detailed description.

Drawings

FIG. 1 shows a schematic front view of the laboratory fume hood with the radiosynthesis laboratory apparatus of the present application capable of self-decontamination and monitoring.

FIG. 2 shows a schematic side view of a self-decontaminating and monitoring radiosynthesis assay device of the present application.

FIG. 3 shows a block diagram of a radiosynthesis assay device that can be self-purified and monitored according to the present application.

Detailed Description

The following description is presented to disclose the invention so as to enable any person skilled in the art to practice the invention. The preferred embodiments in the following description are given by way of example only, and other obvious variations will occur to those skilled in the art. The basic principles of the invention, as defined in the following description, may be applied to other embodiments, variations, modifications, equivalents, and other technical solutions without departing from the spirit and scope of the invention.

It will be understood by those skilled in the art that in the disclosure of the specification, the terms "longitudinal", "lateral", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc., indicate orientations or positional relationships based on those illustrated in the drawings, which are merely for convenience in describing the invention and to simplify the description, and do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and, therefore, the terms should not be construed as limiting the invention.

It is understood that the terms "a" and "an" should be interpreted as meaning that a number of one element or element is one in one embodiment, while a number of other elements is one in another embodiment, and the terms "a" and "an" should not be interpreted as limiting the number.

Referring to fig. 1 and 2, a self-decontaminating and monitoring radiosynthesis experiment apparatus according to a preferred embodiment of the present invention, which is generally disposed in a fume hood to be able to treat radioactivity therethrough and to treat general contamination through the fume hood, will be described in detail below.

The radioactive synthesis experimental device capable of self-purifying and monitoring comprises a device main body 10, a self-purifying mechanism 20, a circulating mechanism 30, an exhaust mechanism 40 and a controller 50, wherein the device main body 10 forms a synthesis cavity and is provided with an air inlet 101, an air outlet 102 and a water supply port 103, the air inlet 101 and the air outlet 102 are communicated with the synthesis cavity, so that inert gas can be introduced into the synthesis cavity through the air inlet 101 to be used as protective gas, a stable and safe experimental environment can be provided for the synthesis experiment, and experimental water can be provided for the synthesis reaction in the synthesis cavity through the water supply port 103.

In addition, the air inlet 101 and the air outlet 102 are both configured with one-way valves to realize one-way air inlet into the synthesis cavity and one-way air outlet from the synthesis cavity.

The self-cleaning mechanism 20 includes a cleaning body 21 and at least one cleaning assembly 22, wherein the cleaning body 21 has a cleaning inlet 201, a cleaning outlet 202 and a cleaning chamber 23 communicating the cleaning inlet 201 and the cleaning outlet 202, wherein the cleaning inlet 201 communicates with the synthesis chamber, and the cleaning assembly 22 is disposed in the cleaning chamber for cleaning radioactive substances in the gas generated during the radioactive synthesis experiment performed in the synthesis chamber.

The circulation mechanism 30 comprises a circulation pipeline 301 for communicating the purification outlet 201 and the synthesis chamber, and at least one radioactivity monitoring element 302, at least one filtering element 303 and at least one circulation pump 304 which are sequentially arranged on the circulation pipeline 301.

The air discharging mechanism 40 includes a discharge pipe 401, and a control valve 402 and at least one air discharging pump 403 which are sequentially disposed on the discharge pipe 401, wherein an opening of the discharge pipe 401 is connected to the circulation pipe 301 and is interposed between the filter element 303 and the circulation pump 304.

The radioactivity monitoring unit 302 is communicatively coupled to the controller 50, and the circulation pump 304, the control valve 402, and the exhaust pump 403 are controllably coupled to the controller 50. The one-way valves provided at both the inlet 101 and the outlet 102 are controllably connected to the controller 50.

Specifically, first, the controller 50 closes the gas inlet 101 and the gas outlet 102 of the synthesis chamber by controlling the one-way valves provided at the gas inlet 101 and the gas outlet 102 to be closed. The controller 50 controls and turns on the exhaust pump 403 to perform pumping so as to detect the air tightness of the synthesis chamber; after the airtightness inspection is finished, opening the gas inlet 101, and introducing inert gas into the synthesis cavity to serve as protective gas to provide a stable and safe experimental environment; conventional radiosynthesis experiments can then be performed in the synthesis chamber. After the radioactive synthesis experiment reaction is finished, the controller 50 controls the circulation pump 304 to operate, the gas in the synthesis cavity is extracted, the gas sequentially passes through the purification inlet 202 and the purification cavity 23 to enter the circulation pipeline 301, so that the gas after being absorbed with radioactive substances is monitored by the radioactive monitoring element 302 to confirm whether the radioactivity in the gas reaches the standard, and if the gas reaches the standard, the gas reaches the standard is discharged by the discharge pipeline 401 after being filtered by the filter element 303. On the contrary, if the gas does not reach the standard, the gas enters the self-purification mechanism 20 again through the circulating pipeline 301 for purification after filtration, and the radioactivity of the gas is detected again after the next purification.

In addition, in order to conveniently view the operation condition of the radiosynthesis experiment device, the device main body 10 is further provided with a wind speed and pressure indicator so as to be capable of observing and monitoring the wind speed and the internal pressure during operation in real time. Such as internal pressure data when performing a gas tightness test.

Generally, the gas radioactivity is effectively reduced by the multiple circulation purification of the self-purification mechanism 20, so as to meet the requirement of outward emission.

The purification assembly 22 includes at least one absorbent assembly 221, wherein the absorbent assembly 221 defines an absorbent cavity 2211. The absorption cavity 2211 contains absorption liquid or absorption gas capable of absorbing radioactive substances in the gas. For different radioactive synthesis experiments, the absorption cavity 2211 can contain an alkaline solution so as to absorb acidic substances; an acidic solution can also be contained to absorb alkaline substances; viscous organic liquids including glycols can also be contained; and can also contain gas with absorption or adsorption effect.

In addition, the absorption assembly 221 may be provided in a plurality of, for example, two or three, and the absorption cavities 2211 of different absorption assemblies 221 contain different absorption liquids or absorption gases, so that the self-purification mechanism 20 can simultaneously purify various radioactive contaminants in the gas of the synthesis cavity.

In addition, the radioactivity monitoring element 302 can be implemented as a surface contamination detection device, such as a surface contamination detector, or as a geiger counter for differences in reactive nuclides.

Therefore, for different radioactive synthesis operations or synthesis operations of different nuclide intermediate states, only the absorbent in the self-purification mechanism 20 needs to be reasonably controlled or adjusted, and the radioactivity monitoring element 302 needs to be correspondingly adjusted, so that the outflow of radioactive pollutants can be effectively controlled, the operation difficulty of radionuclide personnel is reduced, and the working efficiency can be effectively improved.

It is worth mentioning that the radioactive synthesis experimental device capable of self-purifying and monitoring is self-integrated, can flexibly move between different laboratories and fume hoods, and is more convenient to operate.

In a preferred embodiment of the present invention, a support plate 130 is disposed in the synthesis chamber of the apparatus body 10 to divide the synthesis chamber into an upper synthesis chamber 110 and a lower synthesis chamber 120, wherein the support plate 130 is provided with a mounting passage for communicating the upper synthesis chamber 110 with the lower synthesis chamber 120, so that various reaction vessels required for synthesis experiments, such as a round-bottomed flask, a triangular flask, a condenser tube, a purge bottle, a heating magnetic stirrer, a balloon, a syringe, etc., can be placed in the lower synthesis chamber 120, and the radioactive synthesis experiments can be completed in the upper synthesis chamber 110 by the support of the support plate 130.

It is further preferred that the radiosynthesis experiment device further comprises a sealing member 140, wherein the sealing member 140 is covered by the bottom of the device body 10 and extends to the upper synthesis chamber 110 to seal the device body 10, so as to further enhance the sealing performance of the device body 10, and wherein the sealing member 140 is preferably implemented as a groove-shaped member to be able to seal and cover the division of the upper synthesis chamber 110 and the lower synthesis chamber 120.

In a preferred embodiment of the present invention, the purification assembly 22 further comprises at least one condensation assembly 222. The condensing unit 222 is located upstream or downstream of the absorbing unit 221, and the condensing unit 222 forms a condensing chamber 2221. The condensing chamber 2221 communicates the purge inlet 201 with the absorption chamber 2211 or the purge outlet 202 with the absorption chamber 2211. The bottom of the condensing assembly 222 is provided with a condensed gas outlet 2222 communicated with the condensing chamber 2221. Various volatile small molecule emissions are controlled in the condensation chamber 2221 by cooling and condensing, and are directionally discharged through the condensed gas outlet 2222, and meanwhile, may be collected and sealed by a special container, and may also be directionally discharged to a specific place or space, so as to further purify a part of the radioactive contaminants in the process gas.

It should be noted that at least one condensing unit 222 is provided. For some specific cases, the condensing assembly 222 may be disposed in a plurality, and the plurality of condensing assemblies 222 are respectively disposed between the plurality of absorption assemblies 221 in an interposed manner, or disposed upstream or downstream of the plurality of absorption assemblies 221 at the same time. The arrangement of the plurality of condensing units 222 and the plurality of absorbing units 221 is not particularly limited, and the main purpose is to maximally purify the various radioactive contaminants in the process gas by absorbing and condensing the various radioactive contaminants in the gas through a combined arrangement.

In addition, the purification component 22 preferably further comprises at least one adsorption component 223. The adsorption module 223 is located between the purification inlet 201 and the absorption module 221, or between the absorption module 221 and the condensation module 222, or between the condensation module 222 and the circulation mechanism 30, and the adsorption module 223 further forms an adsorption cavity 2231, wherein the adsorption cavity 2231 communicates the purification inlet 201 and the absorption cavity 2211, the absorption cavity 2211 and the condensation cavity 2221, or the condensation cavity 2221 and the purification outlet 202, so as to adsorb the radioactive contaminants in the gas.

Also, at least one of the adsorption assemblies 223. In some cases, there may be a plurality of the adsorption units 223, and the arrangement order between the adsorption unit 223 and the condensation unit 222 and the absorption unit 221 is not particularly limited so as to be able to adsorb, condense and absorb various radioactive contaminants in the gas, respectively.

Preferably, the adsorption module 223 is implemented as a molecular sieve or activated carbon, or a combination of a molecular sieve and activated carbon.

In order to prevent radionuclide personnel from directly contacting radioactive materials and being easily affected by radiation, as a preferred embodiment of the present invention, the device body 10 is further provided with at least one glove hole 104 communicating with the synthesis chamber, and an adjusting glove is disposed at the glove hole 104, wherein the adjusting glove extends toward the synthesis chamber and seals the glove hole 104, so that radionuclide personnel can conveniently build or connect various devices in the synthesis chamber through the adjusting glove, and the leakage of radioactive contamination is not caused, and the health of the personnel is not affected.

Further preferably, the device body 10 is further provided with at least one sampling cavity 105 communicated with the synthesis cavity, wherein a first sampling door is arranged between the sampling cavity 105 and the synthesis cavity, and a second sampling door is arranged at a position of the sampling cavity 105 close to the side wall of the device body 10, so that when sampling is performed in the reaction process, the sampling cavity 105 can be very conveniently sampled through a one-way opening mode, and leakage of radioactive substances is avoided, and the device is safer.

Specifically, under the condition that the first sampling door and the second sampling door are closed simultaneously, the first sampling door is opened firstly, a sample is placed in the sampling cavity 105, then the first sampling door is closed, and then the second sampling door is opened, at this moment, the sampling cavity 105 and the synthesis cavity are cut off and communicated through the first sampling door, so that sampling can be carried out very safely and conveniently.

Preferably, the controller has a predetermined value stored therein in advance. The radioactivity monitoring element 302 is communicatively coupled to the controller 50. The control valve 402, the circulation pump 304 and the exhaust pump 403 are controllably connected to the controller. When the monitored value of the radioactivity monitoring element 302 is fed back to the controller 50 and is lower than the predetermined value, the controller 50 can control the control valve 402 to open and then control the exhaust pump 403 to operate to exhaust the gas; and when the monitored value of the radioactivity monitoring element 302 is fed back to the controller 50 and is not lower than the predetermined value, the controller 50 can control the control valve 402 to be closed, then control the circulation pump 304 to operate, so that the gas enters the synthesis cavity again through the circulation pipeline 301 and enters the self-purification mechanism 20 through the purification inlet 201, is subjected to secondary circulation purification, and is detected again through the radioactivity monitoring element 302 after the secondary circulation purification, so as to circulate until the radioactivity of the gas is lower than the preset standard and is discharged through the discharge pipeline 401.

In general, in the radioactive synthesis experiment, the absorption unit 221, the condensation unit 222, and the adsorption unit 223 in the self-purification mechanism 20 perform absorption treatment, condensation treatment, and adsorption treatment, respectively, and perform cyclic purification five to seven times, thereby effectively reducing the radioactivity of the gas and enabling safe emission.

It should be noted that, in order to purify various radioactive substances generated in the radioactive synthesis experiment, the number of the absorption units 221, the condensation units 222, and the adsorption units 223 may be plural, and the arrangement order among the absorption units 221, the condensation units 222, and the adsorption units 223 may be varied and flexibly adjusted.

Further, it is also possible to manually control whether the gas is secondarily circulated through the circulation line 301 or discharged through the discharge line 401 after the detection by the radioactivity monitoring element 302.

In addition, the present invention also provides an experimental fume hood, wherein the experimental fume hood comprises:

a fume hood body 50 and the above-mentioned radiosynthesis experimental apparatus capable of self-purification and monitoring, wherein the fume hood body 50 forms a fume chamber 501, and a ventilator 502, such as a fan, is disposed on the fume hood body 50 to exhaust gas in the fume chamber 501;

the radiosynthesis assay device is removably disposed within the vented chamber 501.

The ventilation device 502 is controllably connected to the controller 50, such as by electrical signal control or communication control. When the controller 50 obtains a signal related to the operation state of the control valve 402, such as a signal that the control valve 402 is closed or the exhaust pump 403 is not operated, the controller 50 can control the ventilator 502 to be kept in a predetermined power operation, and when the controller 50 monitors that the control valve 402 is opened or the exhaust pump 403 is operated, the controller 50 controls the ventilator 502 to be kept in a power operation greater than the predetermined power operation, so as to realize a low-cost operation of the radiosynthesis experiment. In addition, with the aid of the ventilation device 502, the gas reaching the standard can be discharged more quickly.

It is worth mentioning that when the control valve 402 is closed or the exhaust pump 403 is not running, the running power of the ventilation device 502 is generally kept at about 3.5KW, such as 3.2KW or 3.7KW, so as to form a continuous suction force on the ventilation cavity 501, maintain the negative pressure state of the ventilation cavity 501, ensure that the discharged part of the radioactive gas due to some faults or operation problems can be rapidly discharged, thereby ensuring the safety of the radiosynthesis experimental apparatus in performing the synthesis experiment and avoiding the injury to nearby workers; whereas when the control valve 402 is opened or the exhaust pump 403 is running, the operating power of the ventilator 502 is typically kept around 7KW, such as 6.7KW or 7.5KW, which is much higher than the operating power of the exhaust pump 403 (typically between 0.5KW and 0.6KW), so as to enable rapid evacuation of the gas inside the ventilation chamber 501, further ensuring a satisfactory emission of other gases than radioactive gases, such as pollutant gases.

Therefore, between the two states, through the change of the operating power of the ventilator 502, good linkage cooperation can be generated between the radiosynthesis experiment device and the experimental fume hood, so that the safety of the radiosynthesis experiment can be effectively ensured, the energy consumption can be effectively reduced, and the cost is reduced.

In addition, in order to ensure the quick exhaust function of the ventilator 502, when the operation power of the exhaust pump 403 is large, the operation power of the exhaust pump 403 and the operation power of the ventilator 502 maintain a proportional linear relationship; while the proportional linear relationship is negligible when the operating power of the exhaust pump 403 is much less than the operating power of the ventilator 502.

It is worth mentioning that the control valve 402, the circulation pump 304 and the exhaust pump 403 are all self-contained automation components, such as solenoid valves, electromagnetic pumps, etc., when they are controlled to operate automatically.

In addition, the self-purifiable and monitorable radiosynthesis assay device also includes a shielding gas charging device, wherein the flushing outlet of the shielding gas charging device is in communication with the synthesis chamber, and the shielding gas charging device is controllably connected to the controller 50 to automatically charge the synthesis chamber with inert gas under predetermined conditions.

It should be noted that the terms "first and second" in the present invention are used for descriptive purposes only, do not denote any order, are not to be construed as indicating or implying any relative importance, and are to be interpreted as names.

It will be appreciated by persons skilled in the art that the embodiments of the invention described above and shown in the drawings are given by way of example only and are not limiting of the invention. The advantages of the present invention have been fully and effectively realized. The functional and structural principles of the present invention have been shown and described in the examples, and any variations or modifications of the embodiments of the present invention may be made without departing from the principles.

Claims (10)

1. A radiosynthesis assay device capable of self-purification and monitoring, said radiosynthesis assay device comprising:

the device comprises a device main body, a water supply device and a water supply device, wherein the device main body forms a synthesis cavity and is provided with an air inlet, an air outlet and a water supply port which are communicated with the synthesis cavity;

a self-cleaning mechanism, which comprises a cleaning body and at least one cleaning component, wherein the cleaning body has a cleaning inlet, a cleaning outlet and a cleaning chamber communicating the cleaning inlet and the cleaning outlet, the cleaning inlet communicates with the synthesis chamber, and the cleaning component is disposed in the cleaning chamber for cleaning radioactive substances in the gas;

the circulation mechanism comprises a circulation pipeline communicated with the purification outlet and the synthesis cavity, and at least one radioactivity monitoring element, at least one filtering element and at least one circulation pump which are sequentially arranged in the circulation pipeline;

the air exhaust mechanism comprises an exhaust pipeline, a control valve and at least one air exhaust pump, wherein the control valve and the air exhaust pump are sequentially arranged on the exhaust pipeline, and an opening of the exhaust pipeline is connected with the circulating pipeline and is arranged between the filter element and the circulating pump; and

a controller, said radioactivity monitoring element communicatively coupled to said controller, said circulation pump, said control valve, and said exhaust pump being controllably coupled to said controller.

2. The self-decontaminable and monitorable radiosynthesis assay device of claim 1 wherein a support plate is positioned within said synthesis chamber of said device body to divide said synthesis chamber into an upper synthesis chamber and a lower synthesis chamber, and wherein said support plate is provided with a mounting channel communicating said upper synthesis chamber with said lower synthesis chamber.

3. The self-decontaminating and monitoring radiosynthesis assay device as defined in claim 2 further comprising a seal, wherein said seal is covered by the bottom of said device body and extends to said upper synthesis chamber to seal said device body.

4. The radiosynthesis assay device as defined in any one of claims 1-3 wherein said decontamination module comprises at least one absorbent module, wherein said absorbent module defines an absorbent cavity containing an absorbent liquid or gas capable of absorbing radioactive materials in the gas.

5. The radiosynthesis experiment apparatus as defined in claim 4 wherein said purification module further comprises at least one condensing module disposed upstream or downstream of said absorption module, said condensing module defining a condensing chamber communicating said purification inlet with said absorption chamber or said purification outlet with said absorption chamber, said condensing module having a bottom portion provided with a condensed gas outlet communicating with said condensing chamber.

6. The self-decontaminating and monitoring radiosynthesis assay device as defined in claim 5 wherein said decontamination module further comprises at least one adsorbent module positioned between said decontamination inlet and said adsorbent module, or between said adsorbent module and said condensation module, or between said condensation module and said circulation mechanism, and said adsorbent module defines an adsorbent chamber, wherein said adsorbent chamber communicates between said decontamination inlet and said adsorbent chamber, or between said adsorbent chamber and said condensation chamber, or between said condensation chamber and said decontamination outlet.

7. The self-decontaminable and monitorable radiosynthesis assay device of claim 6 and wherein said device body is further defined by at least one glove port communicating with said synthesis chamber and having an adjustment glove disposed at said glove port, wherein said adjustment glove extends in the direction of said synthesis chamber and seals said glove port.

8. The self-decontaminating and monitoring radiosynthesis assay device as defined in claim 7 wherein said device body further defines at least one sampling chamber in communication with said synthesis chamber, wherein a first sampling gate is disposed between said sampling chamber and said synthesis chamber and a second sampling gate is disposed in said sampling chamber adjacent a sidewall of said device body.

9. The self-decontaminable and monitorable radiosynthesis experiment apparatus as defined in claim 8 wherein said controller has a predetermined value pre-stored therein, said radioactivity monitoring element is communicably connected to said controller, said control valve, said recirculation pump and said exhaust pump are controllably connected to said controller such that when a monitored value of said radioactivity monitoring element is fed back to said controller and said monitored value is below said predetermined value, said controller can control said control valve to open and said exhaust pump to operate, and when a monitored value of said radioactivity monitoring element is fed back to said controller and said monitored value is not below said predetermined value, said controller can control said control valve to close and said recirculation pump to operate.

10. An experimental fume hood, wherein said experimental fume hood comprises:

a fume hood body, wherein the fume hood body forms a fume chamber and a fume device is disposed on the fume hood body to exhaust gases from the fume chamber; and

the self-decontaminable and monitorable radiosynthesis assay device of claim 9 and wherein said radiosynthesis assay device is removably disposable in said ventilation chamber;

wherein the ventilator is controllably connected to the controller such that the controller can control the ventilator to remain operating at a predetermined power when the controller monitors that the control valve is closed or the exhaust pump is not operating, and the controller can control the ventilator to remain operating at a power greater than the predetermined power when the controller monitors that the control valve is open or the exhaust pump is operating.

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