CN113592273A - Monitoring method and monitoring device for mixed medicament preparation - Google Patents
Monitoring method and monitoring device for mixed medicament preparation Download PDFInfo
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Abstract
The method comprises the steps of obtaining a first accumulated flow of a first prepared liquid every other preset time, and calculating the current first flow of the first prepared liquid according to the current preset time and the first accumulated flow obtained in the last preset time; calculating a second flow corresponding to the second liquid preparation according to the current first flow, and enabling the ratio of the first flow to the second flow to be a first ratio; wherein the first ratio is the ratio between the first prepared liquid and the second prepared liquid required by preparing a mixed medicament; and controlling the flow rate of the second preparation liquid prepared in real time by mixing the medicaments to be changed into the second flow rate. The liquid flow can be monitored and adjusted in real time, the mixed medicament configured in each time interval is guaranteed to meet the proportion requirement, and the reliability of the mixed medicament is effectively improved.
Description
Technical Field
The application relates to the technical field of medicament mixing, in particular to a monitoring method and a monitoring device for mixed medicament preparation.
Background
The preparation of the mixed medicament is to mix more than two preparation solutions to be mixed according to the proportion requirement; the currently adopted main mixed medicament preparation method is to set the initial flow rate of each kind of prepared liquid, the proportion between the initial flow rates of each kind of prepared liquid is equal to the proportion requirement of the mixed medicament, the preparation is started, each kind of prepared liquid enters a medicament mixing box for real-time preparation according to the initial flow rate, and the mixed medicament meeting the proportion requirement is obtained.
In the process of preparing the mixed medicaments, due to the change of gravitational potential energy or other emergencies influencing the flow rate of the prepared liquid, each prepared liquid cannot be ensured to enter the mixed medicament box at the initial flow rate all the time, so that the proportion of the prepared mixed medicaments is inconsistent with the proportion requirement, and particularly when the flow rate of one or more prepared liquids cannot be accurately controlled, the error is larger, so that the prepared mixed medicaments cannot be used, and the resource waste is caused.
Disclosure of Invention
In order to ensure that the mixed medicament obtained in the whole preparation process meets the proportion requirement, the prepared mixed medicament can still be used even if the preparation process is stopped or interrupted, and the reliability and the administration efficiency of the preparation of the mixed medicament are improved, the application provides a monitoring method and a monitoring device for the preparation of the mixed medicament.
In a first aspect, the present application provides a monitoring method for mixed drug preparation, which adopts the following technical scheme:
a method of monitoring a mixed pharmaceutical compounding, comprising:
acquiring a first accumulated flow of a first prepared liquid every preset time, and calculating the current first flow of the first prepared liquid according to the current preset time and the first accumulated flow acquired at the last preset time;
calculating a second flow corresponding to the second liquid preparation according to the current first flow, and enabling the ratio of the first flow to the second flow to be a first ratio; wherein the first ratio is the ratio between the first prepared liquid and the second prepared liquid required by preparing a mixed medicament;
and controlling the flow rate of the second preparation liquid prepared in real time by mixing the medicaments to be changed into the second flow rate.
By adopting the technical scheme, the liquid preparation flow can be monitored and adjusted in real time in the preparation process of the mixed medicament, the mixed medicament obtained by mixing in the preparation process of the whole mixed medicament is ensured to meet the first proportion requirement, and the reliability of the preparation of the mixed medicament is effectively improved.
Optionally, before the calculating a second flow rate corresponding to the second liquid preparation according to the current first flow rate and making a ratio of the first flow rate and the second flow rate be a first ratio, the method further includes:
judging whether the current first flow is consistent with the first flow obtained in the last preset time;
and if the first flow rate is inconsistent with the second flow rate, calculating a second flow rate corresponding to the second liquid preparation according to the current first flow rate, and enabling the ratio of the first flow rate to the second flow rate to be a first ratio.
Optionally, before the obtaining of the first accumulated flow of the first liquid preparation at every preset time, the method further includes:
calculating the initial flow of the second liquid preparation according to the theoretical flow of the first liquid preparation and the first proportion;
and controlling the second liquid preparation to start the real-time mixed medicament preparation at the initial flow rate.
Optionally, the monitoring method further includes controlling the preparation of the mixed medicament to stop when the prepared volume of the mixed medicament reaches the preset volume, and controlling the preparation of the mixed medicament to stop according to the received stop instruction.
Optionally, the controlling of the stop of the preparation of the mixed medicament according to the received stop instruction comprises:
receiving a stop instruction;
and controlling the first liquid preparation and the second liquid preparation to stop entering the mixed box according to the stop instruction, and enabling the final ratio of the first accumulated flow of the first liquid preparation and the second accumulated flow of the second liquid preparation to be consistent with the first ratio.
Optionally, the controlling the first liquid preparation and the second liquid preparation to stop entering the mixing box, and making a final ratio of a first accumulated flow of the first liquid preparation and a second accumulated flow of the second liquid preparation consistent with the first ratio includes:
acquiring a first accumulated flow of a current first prepared liquid and a second accumulated flow of a second prepared liquid, and calculating a second proportion of the first accumulated flow and the second accumulated flow;
judging whether the second proportion is consistent with the first proportion or not;
if the second proportion is consistent with the first proportion, controlling the first liquid preparation and the second liquid preparation to stop entering the mixed medicine box;
and if the second proportion is not consistent with the first proportion, controlling the first liquid preparation or the second liquid preparation to stop entering the mixed box, and controlling the second liquid preparation or the first liquid preparation to stop entering the mixed box when the final proportion of the first accumulated flow of the first liquid preparation and the second accumulated flow of the second liquid preparation is consistent with the first proportion.
Optionally, if the second ratio is not consistent with the first ratio, controlling the first liquid preparation or the second liquid preparation to stop flowing into the mixed medicine box, and controlling the second liquid preparation or the first liquid preparation to stop flowing into the mixed medicine box when a final ratio of a first accumulated flow rate of the first liquid preparation and a second accumulated flow rate of the second liquid preparation is consistent with the first ratio, includes:
if the second proportion is not consistent with the first proportion, judging the size of the second proportion and the first proportion;
if the second proportion is smaller than the first proportion, controlling the second liquid preparation to immediately stop entering the mixed medicine box, calculating a first actual accumulated flow of the first liquid preparation of the first proportion when the current second accumulated flow is obtained, and controlling the first liquid preparation to stop entering the mixed medicine box when the first accumulated flow of the first liquid preparation is equal to the first actual accumulated flow;
and if the second proportion is larger than the first proportion, controlling the first liquid preparation to immediately stop entering the mixed medicine box, calculating a second actual accumulated flow of the second liquid preparation with the first proportion and the second liquid preparation proportion equal to the first proportion when the current first accumulated flow is obtained, and controlling the second liquid preparation to stop entering the mixed medicine box when the second accumulated flow of the second liquid preparation is equal to the second actual accumulated flow.
In a second aspect, the present application provides a monitoring device for mixing pharmaceutical preparations, which adopts the following technical solutions:
a monitoring device for mixed medication compounding, comprising a memory, a processor and a computer program stored on the memory and executable on the processor, the processor implementing a method for monitoring mixed medication compounding as described in the first aspect when executing the computer program.
By adopting the technical scheme, the liquid preparation flow is monitored and adjusted in real time in the preparation process of the mixed medicament, the mixed medicament obtained by mixing in the preparation process of the whole mixed medicament is ensured to meet the first proportion requirement, and the reliability of the preparation of the mixed medicament is effectively improved.
In summary, the present application includes at least one of the following beneficial technical effects:
1. the liquid preparation flow can be monitored and adjusted in real time in the mixed medicament preparation process, the proportion of the mixed medicament obtained by stopping preparation at any time in the whole mixed medicament preparation process is ensured to meet the proportion requirement, and the reliability of mixed medicament preparation is effectively improved;
2. unnecessary logic calculation is avoided through a judgment program, so that control delay is reduced, and data processing efficiency and control performance are improved;
3. when the mixed medicament preparation is stopped according to the stop instruction, the error between the currently prepared mixed medicament and the first proportion requirement is calculated, and the small prepared liquid is supplemented according to the difference, so that the proportion accuracy of the prepared mixed medicament is further improved.
Drawings
FIG. 1 is a flow chart of a method of monitoring a mixed dose compounding provided by an embodiment of the present application;
fig. 2 is a flowchart for controlling the first liquid preparation and the second liquid preparation to stop flowing into the mixing box and making the final ratio of the first cumulative flow rate of the first liquid preparation and the second cumulative flow rate of the second liquid preparation coincide with the first ratio in the embodiment of the present application;
fig. 3 is a block diagram of a monitoring device for mixed drug preparation according to an embodiment of the present disclosure.
Detailed Description
In order to make the objects, technical solutions and advantages of the present application more apparent, the present application is further described in detail below with reference to fig. 1-3 and the embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the present application and are not intended to limit the present application.
The embodiment of the application discloses a monitoring method for mixed medicament preparation, which runs in a mixed medicament preparation system, is started synchronously when the mixed medicament preparation is started or is started when the preset volume and/or first proportion of the mixed medicament are received, then the whole process of the mixed medicament preparation is started to be monitored in real time, the flow is controlled in real time to be adjusted, so that the mixed medicament prepared at any moment can meet the proportion requirement, the accuracy of the mixed medicament preparation proportion is improved, and referring to fig. 1, the monitoring method for the mixed medicament preparation comprises the following steps:
step S100, acquiring a first accumulated flow of first liquid distribution from a first flow meter arranged at a first liquid distribution inlet at intervals of preset time (in order to reduce requirements on a deployment processor and realize flow control, the common preset time is set to be more than 10S), and calculating a current first flow of the first liquid distribution according to the current preset time and two first accumulated flows acquired at the last preset time; the first flow meter is equipment capable of performing accumulated flow counting, such as a water meter and the like; the first accumulated flow is the volume of the first prepared liquid entering the mixed medicine box from the preparation start to the end of the current preset time; the current first flow rate is the average flow rate of the first liquid preparation in the current preset time.
In this embodiment, a user may input a preset volume and a first ratio that a mixed medicament needs to be prepared according to a requirement (or directly input a name of the mixed medicament, and obtain a corresponding first ratio according to the name of the mixed medicament). It should be noted that the first liquid preparation in this embodiment is a general term for a liquid preparation that cannot be controlled or is not controlled, and includes one or more liquid preparations, and the second liquid preparation is a general term for a liquid preparation that can be controlled with precise flow, and includes one or more liquid preparations; in this embodiment, before the preparation starts, the method further comprises the steps of calculating an initial flow rate of the second preparation according to the theoretical flow rate of the first preparation and the first ratio, then starting the preparation of the mixed medicament, and controlling each second preparation to start the preparation of the mixed medicament in real time at the initial flow rate, so that errors between the ratios of the prepared mixed medicaments and the first ratio are small even before the first preset time comes; of course, the initial flow calculation may not be performed, and the proportional adjustment may be implemented when the preset time comes.
Step S200, according to a first ratio between the first prepared liquid and each second prepared liquid required by the mixed medicament preparation and the current first flow rate, calculating a second flow rate corresponding to the second prepared liquid, and enabling the ratio of the first flow rate and the second flow rate to be the first ratio, namely enabling the second flow rate to be equal to the first flow rate divided by the first ratio.
And step S300, changing the flow rate of the second liquid preparation for preparing the mixed medicament in real time into a second flow rate, and controlling each second liquid preparation to prepare the liquid in real time according to the corresponding second flow rate. The second flow rate of the second liquid preparation of the embodiment can be accurately regulated to a set value according to needs, so that the second flow rate is the instantaneous flow rate of the second liquid preparation and the average flow rate in the current preset time.
This application embodiment is through being equipped with the process at mixed medicament and monitoring and adjusting the second liquid flow of joining in marriage in real time, guarantee that the mixed medicament that the preparation process of whole mixed medicament mixes the acquisition all accords with first proportion requirement, even stop or interrupt the outfit before the unfinished mixed medicament of needs volume is equipped, also can guarantee that the every kind of liquid proportion of joining in marriage of mixed medicament of having equipped accords with first proportion requirement, can carry out the medicine application, the effectual reliability and the work efficiency who improves mixed medicament and allocate, avoid extravagant.
In another embodiment of the present application, if the first flow rate is not changed due to an external reason, the second flow rate of the second dispensing solution keeps the current value to ensure that the ratio of the mixed medicament prepared is consistent with the first ratio, and the second flow rate of the second dispensing solution does not need to be changed, so that the second flow rate does not need to be calculated, and therefore, in order to avoid performing unnecessary logic calculation, thereby reducing control delay and improving data processing efficiency and control performance, before executing step S200, the method further includes determining whether the current first flow rate is consistent with the first flow rate obtained at the last preset time, and if so, executing step S100; if not, step S200 is executed.
In the present embodiment, the present application of stopping preparing mixed medicines includes the following two cases:
(1) if the volume of the mixed medicament obtained by preparation reaches the preset volume, automatically stopping the preparation of the mixed medicament; the embodiment does not limit the method for judging the volume of the prepared mixed medicament to reach the preset volume, and the mixed medicament preparation is triggered to stop as long as the volume of the mixed medicament to be prepared is judged to reach the preset volume; the determination of whether the volume of the mixed medicament that has been prepared has reached the volume of the mixed medicament that needs to be prepared is made, for example, by counting up on the first flow meter and the second flow meter whether the first volume and the second volume are reached, and if the first flow meter and the second flow meter have counted up on the first flow meter and the second flow meter, feedback information from the first flow meter and the second flow meter is received, and the mixed medicament preparation is triggered to stop according to the feedback information.
(2) And when the volume of the mixed medicament obtained by the preparation does not reach the preset volume, receiving a stop instruction of a user, and controlling the preparation of the mixed medicament to stop according to the stop instruction. In this case, in order to further improve the accuracy of the ratio of the mixed medicaments already prepared, in some embodiments, controlling the stop of the preparation of the mixed medicaments according to the received stop instruction comprises the steps of:
receiving a stop instruction;
and controlling the first liquid preparation and the second liquid preparation to stop flowing into the mixed medicine box according to the stop command, and enabling the final ratio of the first accumulated flow of the first liquid preparation and the second accumulated flow of the second liquid preparation to be consistent with the first ratio.
In order to ensure that the final ratio of the first cumulative flow rate of the first liquid formulation and the second cumulative flow rate of the second liquid formulation matches the first ratio, in the present embodiment, the first liquid formulation and the second liquid formulation are controlled to stop flowing into the mixing box, and the final ratio of the first cumulative flow rate of the first liquid formulation and the second cumulative flow rate of the second liquid formulation matches the first ratio, as shown in fig. 2, the method includes:
step S301, a first accumulated flow of the current first liquid preparation and a second accumulated flow of the second liquid preparation are obtained, and a second proportion of the first accumulated flow and the second accumulated flow is calculated.
Step S302, judging whether the second proportion is consistent with the first proportion, and if so, executing step S303; otherwise, step S304 is performed.
And step S303, controlling the first liquid preparation and the second liquid preparation to stop entering the mixed medicine box.
Step S304, judging the size of the second proportion and the first proportion, and if the second proportion is smaller than the first proportion, executing step S305; if the second ratio is greater than the first ratio, step S307 is performed.
And S305, controlling the second liquid preparation to immediately stop entering the mixed box, and calculating a first actual accumulated flow of the first liquid preparation with the first liquid preparation and second liquid preparation ratio equal to the first ratio when the current second accumulated flow is obtained.
And S306, controlling the first liquid preparation to stop entering the mixed medicine box when the first accumulated flow of the first liquid preparation is equal to the first actual accumulated flow.
And step S307, controlling the first liquid preparation to immediately stop entering the mixed box, and calculating a second actual accumulated flow of the second liquid preparation when the current first accumulated flow is equal to the first ratio between the first liquid preparation and the second liquid preparation.
And step S308, controlling the second liquid preparation to stop entering the mixed medicine box when the second accumulated flow of the second liquid preparation is equal to the second actual accumulated flow.
That is, when the final ratio of the first cumulative flow rate of the first solution and the second cumulative flow rate of the second solution does not match the first ratio, one of the first solution and the second solution is controlled to stop, the corresponding other (the second solution or the first solution) continues to enter the mixing tank until the error caused by the first solution is compensated, and when the ratio of the first solution and the second solution in the mixed medicine matches the first ratio, the other is controlled to stop flowing into the mixing tank.
The embodiment of the present application further discloses a monitoring device for mixed drug preparation, which is deployed in a mixed drug preparation system and monitors a preparation process of the mixed drug preparation system, and specifically, the device includes: one or more processors and memory, as shown in FIG. 3, take the example of a processor 200 and memory 100. The processor 200 and the memory 100 may be connected by a bus or other means, such as by a bus connection for example.
The memory 100 is used as a non-transitory computer readable storage medium for storing a non-transitory software program and a non-transitory computer executable program, such as a method for monitoring a mixed pharmaceutical preparation in an embodiment of the present application. The processor 200 implements a method of monitoring a mixed dose preparation as described in the embodiments of the present application by running a non-transitory software program and instructions stored in the memory 100.
The memory 100 may include a storage program area and a storage data area, wherein the storage program area may store an operating device, an application program required for at least one function; the storage data area may store data and the like necessary to execute the monitoring method of one of the mixed medication preparations in the above-described embodiments. Further, the memory 100 may include high speed random access memory, and may also include non-transitory memory, such as at least one magnetic disk storage device, flash memory device, or other non-transitory solid state storage device. In some embodiments, the memory optionally includes memory located remotely from the processor, and these remote memories may be connected to the terminal over a network. Examples of such networks include, but are not limited to, the internet, intranets, local area networks, mobile communication networks, and combinations thereof.
In addition, the embodiment of the application further discloses a mixed medicament preparation system, which includes, but is not limited to, a medicament mixing box, a volume setting device, a stop instruction receiving device, a first flowmeter and a second flowmeter arranged at a first liquid preparation and second liquid preparation inlet of the medicament mixing box, a first liquid preparation stopping and starting device and a second liquid preparation stopping and starting device for stopping or starting the first liquid preparation and the second liquid preparation to enter the medicament mixing box according to an instruction, a first liquid preparation box and a second liquid preparation box for accommodating the first liquid preparation and the second liquid preparation, a peristaltic pump arranged between a liquid outlet of the second liquid preparation box and a second liquid preparation inlet of the medicament mixing box, and a monitoring device for mixed medicament preparation provided by the embodiment of the application.
Setting a preset volume and a first proportion of the mixed medicament by a user through a volume setting device; and controlling the first liquid preparation stopping and starting device and the second liquid preparation stopping and starting device to start liquid preparation.
In the preparation process, a monitoring device for preparing the mixed medicament obtains a first accumulated flow of the first prepared liquid and a second accumulated flow of the second prepared liquid from the first flowmeter and the second flowmeter at preset time intervals, and calculates a current first flow of the first prepared liquid according to the current preset time and the first accumulated flow obtained at the last preset time; and then calculating a second flow rate corresponding to the second liquid preparation according to a first proportion and a first flow rate between the first liquid preparation and each second liquid preparation required by the mixed medicament obtained from the volume setting device, controlling each second liquid preparation through a peristaltic pump to change the flow rate, and performing real-time liquid preparation according to the second flow rate.
When the prepared mixed medicament volume reaches the mixed medicament volume required to be prepared, the monitoring device for preparing the mixed medicament stops preparing the mixed medicament by controlling the first liquid preparation stopping and starting device and the second liquid preparation stopping and starting device.
When the volume of the mixed medicament obtained by preparation does not reach the volume of the mixed medicament to be prepared, if the user sends a stop instruction through the stop instruction receiving device, the monitoring device for preparing the mixed medicament stops the preparation of the mixed medicament by controlling the first liquid preparation stop device and/or the second liquid preparation stop device according to the received stop instruction.
The medicine dispensing system provided by the application adopts the monitoring device provided by the embodiment of the application to control medicine dispensing, can monitor and adjust the liquid dispensing flow in real time in the preparation process of the mixed medicine, ensures that the mixed medicine obtained in the whole mixed medicine preparation process conforms to the first proportion requirement, and effectively improves the reliability of the mixed medicine preparation.
The foregoing is a preferred embodiment of the present application and is not intended to limit the scope of the application in any way, and any features disclosed in this specification (including the abstract and drawings) may be replaced by alternative features serving equivalent or similar purposes, unless expressly stated otherwise. That is, unless expressly stated otherwise, each feature is only an example of a generic series of equivalent or similar features.
Claims (8)
1. A method of monitoring a compounding medication, comprising:
acquiring a first accumulated flow of a first prepared liquid every preset time, and calculating the current first flow of the first prepared liquid according to the current preset time and the first accumulated flow acquired at the last preset time;
calculating a second flow corresponding to the second liquid preparation according to the current first flow, and enabling the ratio of the first flow to the second flow to be a first ratio; wherein the first ratio is the ratio between the first prepared liquid and the second prepared liquid required by preparing a mixed medicament;
and controlling the flow rate of the second preparation liquid prepared in real time by mixing the medicaments to be changed into the second flow rate.
2. The monitoring method according to claim 1, wherein before the calculating a second flow rate corresponding to the second liquid preparation according to the current first flow rate and making a ratio of the first flow rate and the second flow rate a first ratio, the method further comprises:
judging whether the current first flow is consistent with the first flow obtained in the last preset time;
and if the first flow rate is inconsistent with the second flow rate, calculating a second flow rate corresponding to the second liquid preparation according to the current first flow rate, and enabling the ratio of the first flow rate to the second flow rate to be a first ratio.
3. The monitoring method according to claim 1, before the obtaining the first accumulated flow rate of the first dispensing at every preset time, further comprising:
calculating the initial flow of the second liquid preparation according to the theoretical flow of the first liquid preparation and the first proportion;
and controlling the second liquid preparation to start the real-time mixed medicament preparation at the initial flow rate.
4. The monitoring method of claim 1, further comprising controlling the dispensing of the mixed medication to stop when the dispensed volume of mixed medication reaches a preset volume, and controlling the dispensing of the mixed medication to stop in response to a received stop command.
5. The monitoring method of claim 4, wherein the controlling of the stop of the compounding of the mixed medication in accordance with the received stop instruction comprises:
receiving a stop instruction;
and controlling the first liquid preparation and the second liquid preparation to stop entering the mixed box according to the stop instruction, and enabling the final ratio of the first accumulated flow of the first liquid preparation and the second accumulated flow of the second liquid preparation to be consistent with the first ratio.
6. The monitoring method of claim 5, wherein said controlling the first and second dosing solutions to stop entering the mixing tank and the final ratio of the first cumulative flow rate of the first dosing solution and the second cumulative flow rate of the second dosing solution to be consistent with the first ratio comprises:
acquiring a first accumulated flow of a current first prepared liquid and a second accumulated flow of a second prepared liquid, and calculating a second proportion of the first accumulated flow and the second accumulated flow;
judging whether the second proportion is consistent with the first proportion or not;
if the second proportion is consistent with the first proportion, controlling the first liquid preparation and the second liquid preparation to stop entering the mixed medicine box;
and if the second proportion is not consistent with the first proportion, controlling the first liquid preparation or the second liquid preparation to stop entering the mixed box, and controlling the second liquid preparation or the first liquid preparation to stop entering the mixed box when the final proportion of the first accumulated flow of the first liquid preparation and the second accumulated flow of the second liquid preparation is consistent with the first proportion.
7. The monitoring method according to claim 6, wherein said controlling the first dosing liquid or the second dosing liquid to stop flowing into the mixing box if the second ratio is not consistent with the first ratio, and controlling the second dosing liquid or the first dosing liquid to stop flowing into the mixing box when a final ratio of a first cumulative flow rate of the first dosing liquid and a second cumulative flow rate of the second dosing liquid is consistent with the first ratio comprises:
if the second proportion is not consistent with the first proportion, judging the size of the second proportion and the first proportion;
if the second proportion is smaller than the first proportion, controlling the second liquid preparation to immediately stop entering the mixed medicine box, calculating a first actual accumulated flow of the first liquid preparation of the first proportion when the current second accumulated flow is obtained, and controlling the first liquid preparation to stop entering the mixed medicine box when the first accumulated flow of the first liquid preparation is equal to the first actual accumulated flow;
and if the second proportion is larger than the first proportion, controlling the first liquid preparation to immediately stop entering the mixed medicine box, calculating a second actual accumulated flow of the second liquid preparation with the first proportion and the second liquid preparation proportion equal to the first proportion when the current first accumulated flow is obtained, and controlling the second liquid preparation to stop entering the mixed medicine box when the second accumulated flow of the second liquid preparation is equal to the second actual accumulated flow.
8. A monitoring device for mixed pharmaceutical preparations, comprising a memory, a processor and a computer program stored on the memory and executable on the processor, characterized in that the processor implements a method for monitoring mixed pharmaceutical preparations according to any one of claims 1 to 7 when executing the computer program.
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