CN113587504B

CN113587504B - Refrigerating device, reagent storage device and in-vitro diagnostic instrument

Info

Publication number: CN113587504B
Application number: CN202110859536.9A
Authority: CN
Inventors: 孙盼盼; 张焕贵
Original assignee: Guangzhou Wondfo Biotech Co Ltd
Current assignee: Guangzhou Wondfo Biotech Co Ltd
Priority date: 2021-07-28
Filing date: 2021-07-28
Publication date: 2023-04-07
Anticipated expiration: 2041-07-28
Also published as: CN113587504A

Abstract

The invention discloses a refrigerating device, a reagent storage device and an in-vitro diagnostic instrument. The refrigerating device comprises a water cooling head and a fluid cooling device; the water cooling head is provided with a first outlet and a first inlet; the fluid cooling device is provided with a second outlet and a second inlet, the second outlet is communicated with the first inlet through a pipeline, the second inlet is communicated with the first outlet through a pipeline, and the water cooling head and the fluid cooling device form a loop. The technical scheme provided by the refrigerating device, the reagent storage device and the in-vitro diagnostic instrument is that the water-cooling head is matched with the fluid cooling device, so that the device to be cooled can be quickly cooled to keep the low-temperature state of the device to be cooled, and the heat dissipation effect is good; the device can omit the use of a TEC module for radiating the device to be cooled, and has the characteristics of simple structure, strong heat radiation, low energy consumption, difficult damage, low cost and low noise of the whole machine.

Description

Refrigerating device, reagent storage device and in-vitro diagnostic instrument

Technical Field

The invention belongs to the technical field of in-vitro diagnosis automation equipment, and particularly relates to a refrigerating device, a reagent storage device and an in-vitro diagnosis instrument.

Background

In the existing immunoassay, various reaction reagents are required to be refrigerated to ensure the use effect. The technology of temperature control cooling of a reagent chamber on the market at present basically adopts a TEC (semiconductor cooler) arranged at the bottom of the reagent chamber, the TEC cooler is made by using the Peltier effect of a semiconductor material, wherein a refrigerating surface of the TEC cooler is directly contacted with the surface of the reagent chamber bottom plate, and a heating surface opposite to the refrigerating surface can generate a large amount of heat while the refrigerating surface is refrigerating. The commonly used heat dissipation methods are: heat pipe radiator + fan, water-cooling row + fan, radiator + fan. These heat dissipation methods have the following problems: (1) poor heat dissipation capability; (2) The COP value of the TEC is generally only about 0.3-0.6, and the energy consumption of the system is high; (3) The TEC shell is made of ceramic material, and is very easy to generate fracturing in the installation process to fail; (4) the medical industry uses high-end TECs with high cost; and (5) the whole machine has higher noise.

Disclosure of Invention

The invention aims to provide an in-vitro diagnostic instrument which is used for overcoming the defects of poor heat dissipation capability, high system energy consumption, high cost and high overall noise of the prior art in which a TEC refrigerator is adopted to refrigerate a reagent bin.

The technical scheme is as follows:

a refrigeration apparatus comprising a water cooling head and a fluid cooling device;

the water cooling head is provided with a first outlet and a first inlet; the fluid cooling device is provided with a second outlet and a second inlet, the second outlet is communicated with the first inlet through a pipeline, the second inlet is communicated with the first outlet through a pipeline, and the water cooling head and the fluid cooling device form a loop.

In one embodiment, the fluid cooling device comprises a cold heat exchanger and a heat dissipation mechanism;

the cold heat exchanger has a cold end and a hot end connected to the cold end, the cold end having the second outlet and the second inlet; the hot end is provided with a third outlet and a third inlet, the heat dissipation mechanism is provided with a fourth outlet and a fourth inlet, the fourth outlet is communicated with the third inlet through a pipeline, the fourth inlet is communicated with the third outlet through a pipeline, and the hot end and the heat dissipation mechanism form a loop.

In one embodiment, the cold heat exchanger is a plate heat exchanger.

In one embodiment, the heat dissipation mechanism is a cooling tower.

In one embodiment, the fluid cooling device comprises a thermostatic water tank having the second outlet and the second inlet thereon.

In one embodiment, the constant-temperature water tank comprises a tank body, and a condenser, a compressor and an evaporator which are arranged in the tank body; the tank having the second outlet and the second inlet;

the second inlet, the condenser, the compressor, the evaporator and the second outlet are communicated in sequence through pipelines.

In one embodiment, the constant-temperature water tank further comprises a water storage tank and a water pump which are arranged in the tank body; the cistern set up in the second entry of box with between the condenser, just second entry, cistern, water pump with the condenser loops through the pipeline intercommunication.

In one embodiment, the constant-temperature water tank further comprises a control panel arranged on the tank body.

In one embodiment, at least two water cooling heads are arranged, at least two water cooling heads are sequentially communicated through a pipeline, the water cooling head at the head end is communicated with the second outlet of the fluid cooling device through a pipeline, and the water cooling head at the tail end is communicated with the second inlet of the fluid cooling device through a pipeline.

A reagent storage device comprising a reagent cartridge and a refrigeration device as described above; the water cooling head is arranged at the bottom of the reagent bin.

In one embodiment, the reagent storage device further comprises a heat conducting member disposed between the water-cooled head and the reagent chamber.

In one embodiment, a first heat preservation layer is arranged on the outer wall of the reagent cabin around the water cooling head.

In one embodiment, the side wall of the water cooling head is provided with a step in the radial direction of the water cooling head, and the cross-sectional area of the water cooling head close to the first end of the reagent bin is smaller than that of the second end; the first heat preservation layer is arranged on the step.

In one embodiment, an air blowing device is further arranged in the reagent bin.

An in vitro diagnostic apparatus comprising a reagent storage device as described above; the in-vitro diagnostic instrument also comprises an incubation bin;

the incubation bin comprises a first ring body and a second ring body; the second ring body is sleeved on the first ring body at intervals; and a space between the first ring body and the second ring body forms a flow passage, and an inlet and an outlet of the flow passage are communicated with a pipeline between the first outlet of the water cooling head and the second inlet of the fluid cooling device through pipelines.

In one embodiment, the in-vitro diagnostic apparatus further comprises a three-way valve disposed between the first outlet of the water-cooling head and the second inlet of the fluid cooling device, and the incubation chamber and the fluid cooling device are both controlled by the three-way valve to communicate with the water-cooling head.

In one embodiment, the incubation bin further comprises a third ring body, the third ring body is sleeved on the second ring body at intervals, and a PI heating film is arranged in a space between the second ring body and the third ring body.

In one embodiment, a second insulating layer is arranged between the wall of the incubation bin and the outer wall of the third ring body.

The technical scheme provided by the invention has the following advantages and effects:

this refrigerating plant is through setting up water-cooling head and fluid cooling device, the fluid through fluid cooling device refrigerated flows in the water-cooling head, the water-cooling head absorbs the heat of treating cooling device like reagent storehouse, and the refrigerated fluid through flowing in the water-cooling head carries out the replacement, so that treat cooling device and keep the low temperature state, fluid after the absorbed heat flows in fluid cooling device from the water-cooling head and cools off, get into the water-cooling head again afterwards and carry out circulation flow, so as to treat cooling device and carry out circulation heat dissipation, so as to treat cooling device fast and dispel the heat in order to keep treating cooling device's low temperature state, the radiating effect is good. Therefore, the refrigerating device is matched with the fluid cooling device through the water cooling head, the TEC module can be omitted for radiating the cooling device to be treated, and the refrigerating device has the advantages of being simple in structure, strong in radiating, low in energy consumption, not prone to damage, low in cost and low in noise of the whole machine.

Drawings

The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and, together with the description, serve to explain the principles and effects of the invention.

Unless otherwise specified or defined, the same reference numerals in different figures refer to the same or similar features, and different reference numerals may be used for the same or similar features.

FIG. 1 is a schematic view of the structure of a reagent storage apparatus according to embodiment 1 of the present invention;

FIG. 2 is a schematic diagram of the construction of another embodiment of the reagent storage device of FIG. 1;

FIG. 3 is a schematic view of the structure of a reagent storage apparatus according to embodiment 2 of the present invention;

FIG. 4 is a schematic structural view of another embodiment of the reagent storage device of FIG. 3;

FIG. 5 is a schematic view of an in vitro diagnostic apparatus including the embodiment 1 of FIG. 1;

FIG. 6 is a schematic structural view of an in vitro diagnostic apparatus including embodiment 2 of FIG. 3;

fig. 7 is a schematic diagram of the structure of the incubation chamber of the in-vitro diagnostic apparatus of fig. 5 or 6.

Description of reference numerals:

100. a refrigeration device;

1. a water cooling head; 11. a first outlet; 12. a first inlet; 2. a fluid cooling device; 21. a second outlet; 22. a second inlet; 23. a cold-heat exchanger; 231. a cold end; 232. a hot end; 2321. a third outlet; 2322. a third inlet; 24. a heat dissipation mechanism; 241. a fourth outlet; 242. a fourth inlet; 25. a constant temperature water tank; 251. a box body; 252. a condenser; 253. a compressor; 254. an evaporator; 255. a reservoir; 256. a water pump; 257. a control panel;

200. a reagent bin; 300. a first insulating layer; 400. an incubation bin; 410. a first ring body; 420. a second ring body; 430. a flow channel; 440. a third ring body; 450. PI heating film; 460. a second insulating layer; 500. and a three-way valve.

Detailed Description

In order that the invention may be readily understood, specific embodiments thereof will be described in more detail below with reference to the accompanying drawings.

Unless specifically stated or otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In the case of combining the technical solutions of the present invention in a realistic scenario, all technical and scientific terms used herein may also have meanings corresponding to the purpose of achieving the technical solutions of the present invention.

As used herein, unless otherwise specified or defined, "first, \ 8230," is used merely to distinguish between names, and does not denote a particular quantity or order.

As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items, unless specified or otherwise defined.

It will be understood that when an element is referred to as being "secured to" another element, it can be directly secured to the other element or intervening elements may also be present; when an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present; when an element is referred to as being "mounted on" another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "on" another element, it can be directly on the other element or intervening elements may also be present.

Note that, as shown in fig. 1 or fig. 3, the refrigeration apparatus 100 is used to refrigerate a device to be cooled to maintain a low temperature state. Specifically, in this embodiment, the refrigeration device 100 is mainly used in an in vitro diagnostic apparatus to refrigerate the reagent chamber 200, so as to maintain the low temperature state of the reagent chamber 200 to meet the reagent storage requirement. Of course, in other embodiments, the refrigeration device 100 may also be used in other devices to be cooled that require refrigeration to form a low temperature state, and is not limited herein. For convenience of description, the refrigerating device 100 is mainly used in an in vitro diagnostic apparatus to refrigerate the reagent chamber 200.

The invention provides a refrigeration device 100, as shown in fig. 1 or fig. 3, the refrigeration device 100 comprises a water cooling head 1 and a fluid cooling device 2.

As shown in fig. 1 or fig. 3, the water-cooling head 1 has a first outlet 11 and a first inlet 12; specifically, in this embodiment, the water cooling head 1 is configured to be disposed at the bottom of the reagent chamber 200, so that heat of the reagent chamber 200 is conducted to the water cooling head 1. The fluid cooling device 2 has a second outlet 21 and a second inlet 22, and it should be noted that the fluid cooling device 2 is used for introducing a fluid and cooling the fluid, and the fluid may be specifically gas, water or other fluid media, and is not limited herein. The second outlet 21 is communicated with the first inlet 12 through a pipeline, the second inlet 22 is communicated with the first outlet 11 through a pipeline, and the water cooling head 1 and the fluid cooling device 2 form a loop. It will be appreciated that the fluid can flow from the fluid cooling device 2 into the water cooling head 1 and from the water cooling head 1 into the fluid cooling device 2 for circulation.

It will be appreciated that the principle of operation of the refrigeration unit 100 is substantially as follows: the reagent bin 200 can bring heat into the reagent bin 200 in the processes of reagent placing and cover opening, the water-cooling head 1 is arranged at the bottom of the reagent bin 200, the fluid is introduced into the fluid cooling device 2 to be cooled to form cooling fluid, the cooling fluid flows out through the second outlet 21 and flows into the water-cooling head 1 after sequentially flowing through the pipeline and the first inlet 12, the water-cooling head 1 absorbs the heat of the reagent bin 200 and is replaced by the cooling fluid flowing into the water-cooling head 1, so that the reagent bin 200 is kept in a low-temperature state, the fluid after absorbing the heat flows out from the first outlet 11 of the water-cooling head 1 and flows into the fluid cooling device 2 through the pipeline and the second inlet 22 to be cooled, and then enters the water-cooling head 1 to circularly flow, so that the reagent bin 200 is circularly cooled through the structure, and the low-temperature state of the reagent bin 200 is kept.

In summary, compared with the prior art, the refrigeration device 100 has at least the following beneficial effects: according to the refrigerating device 100, the water cooling head 1 and the fluid cooling device 2 are arranged, fluid cooled by the fluid cooling device 2 flows into the water cooling head 1, the water cooling head 1 absorbs heat of a device to be cooled such as the reagent bin 200 and is replaced by the cooled fluid flowing into the water cooling head 1, so that the device to be cooled is kept in a low-temperature state, the fluid after absorbing the heat flows into the fluid cooling device 2 from the water cooling head 1 to be cooled and then enters the water cooling head 1 again to flow in a circulating mode, the device to be cooled can be subjected to circulating heat dissipation, the device to be cooled can be rapidly cooled so that the low-temperature state of the device to be cooled can be kept, and the heat dissipation effect is good. Therefore, the refrigeration device 100 is matched with the fluid cooling device 2 through the water cooling head 1, the TEC module can be omitted from being used for radiating heat of the device to be cooled, and the refrigeration device has the advantages of being simple in structure, strong in radiating, low in energy consumption, not prone to damage, low in cost and low in noise of the whole machine.

In some embodiments, as shown in fig. 1, the fluid cooling device 2 includes a cold heat exchanger 23 and a heat dissipation mechanism 24. Cold heat exchanger 23 has a cold end 231 and a hot end 232 connected to cold end 231, cold end 231 having a second outlet 21 and a second inlet 22; the hot end 232 is provided with a third outlet 2321 and a third inlet 2322, the heat dissipation mechanism 24 is provided with a fourth outlet 241 and a fourth inlet 242, the fourth outlet 241 is communicated with the third inlet 2322 through a pipeline, the fourth inlet 242 is communicated with the third outlet 2321 through a pipeline, and the hot end 232 and the heat dissipation mechanism 24 form a loop. It can be understood that the water flowing into the water-cooled head 1 from the second outlet 21 of the cold-heat exchanger 23 is a low-temperature fluid, and the low-temperature fluid enters from the first inlet 12 of the water-cooled head 1, then flows out from the first outlet 11 of the water-cooled head 1 and enters from the second inlet 22 into the cold end 231 of the cold-heat exchanger 23, during which the low-temperature fluid takes away the heat stored in the water-cooled head 1, the temperature rises, and finally enters into the cold end 231 of the cold-heat exchanger 23 and transfers the heat to the heat dissipation mechanism 24 through the hot end 232 to dissipate the heat, and then the low-temperature fluid flows into the water-cooled head 1 again to form an internal circulation. Similarly, the water coming out of the fourth outlet 241 of the heat sink 24 is the low-temperature fluid, and enters the hot end 232 of the cold heat exchanger 23 through the third inlet 2322, and then returns to the heat sink 24 from the third outlet 2321 of the hot end 232 to dissipate heat, and the low-temperature fluid flows into the hot end 232 of the cold heat exchanger 23 again to form an external circulation; the low temperature fluid circulating outside the heat exchanger 23 takes away the heat circulating inside the heat exchanger 23 and enters the heat dissipation mechanism 24, and the heat dissipation mechanism 24 discharges the heat outdoors for heat dissipation. Through mutual cooperation of cold and heat exchanger 23 and heat dissipation mechanism 24, refrigeration efficiency is high, can guarantee to treat that cooling device is in the low temperature state as reagent storehouse 200 always, and this cold and heat exchanger 23 and heat dissipation mechanism 24 can be installed in the position of keeping away from treating cooling device according to actual installation needs components of a whole that can function independently, can reduce overall structure's size, and can effectively avoid influencing the cooling effect of treating cooling device in the heat dissipation process of heat dissipation mechanism 24.

In some embodiments, as shown in fig. 1, the cold heat exchanger 23 is a plate heat exchanger. It will be appreciated that a plate heat exchanger is a heat exchanger formed by stacking a series of metal sheets having a corrugated shape, with thin rectangular channels formed between the various sheets through which heat is exchanged. The plate heat exchanger is a device for liquid-liquid heat exchange, so that the device to be cooled can be cooled by adopting water as a medium, the water as the medium has the characteristics of low cost and good cooling effect, and the plate heat exchanger has the characteristics of high heat exchange efficiency, small heat loss, compact and light structure, small occupied area, wide application, long service life and the like.

In some embodiments, as shown in fig. 1, the heat dissipation mechanism 24 is a cooling tower, which has the characteristics of low cost and good heat dissipation effect. This cooling water tower can carry out quick cooling with water, and water carries out heat exchange and matter exchange with the air that flows through wherein, causes the temperature decline to form low temperature water and gets into plate heat exchanger's hot junction 232 and return cooling water tower again after carrying out the heat exchange with the water of cold junction 231 and carry out the cooling that dispels the heat once more to cool off the water of cold junction 231 and form cooling water entering water-cooling head 1 and treat cooling device and cool off.

In some embodiments, as shown in fig. 3, the fluid cooling device 2 comprises a constant temperature water tank 25, and the constant temperature water tank 25 is provided with a second outlet 21 and a second inlet 22. It can understand, carry out the constant temperature cooling through constant temperature water tank 25 fluid, the heat that water-cooling head 1 storage is taken away to the low-temperature fluid, the temperature risees, it becomes the low-temperature fluid once more and flows in water-cooling head 1 formation circulation to enter into constant temperature water tank 25 at last, the characteristics that refrigeration efficiency is high have, this constant temperature water tank 25 can be installed in the position of keeping away from and treating cooling device according to actual installation needs components of a whole that can function independently, can reduce overall structure's size, and can guarantee to treat that cooling device is in the constant temperature state, adopt water as the medium to get into constant temperature water tank 25 and carry out the constant temperature cooling in order to treat cooling device and cool off, water cools off as the medium has with low costs, the characteristics that the cooling effect is good.

In some embodiments, as shown in fig. 4, the constant-temperature water tank 25 includes a tank 251, and a condenser 252, a compressor 253, and an evaporator 254 disposed within the tank 251; the case 251 has a second outlet 21 and a second inlet 22; the second inlet 22, the condenser 252, the compressor 253, the evaporator 254, and the second outlet 21 are sequentially communicated through pipes. It should be noted that, high-temperature water coming out of the water-cooled head 1 enters the condenser 252 through the second inlet 22 to be collected, and then enters the evaporator 254 through the compressor 253, water in the constant-temperature water tank 25 is cooled by the compressor 253 and the evaporator 254 to form low-temperature water, the low-temperature water flows out of the low-temperature water to the water-cooled head 1 through the second outlet 21, and continuous cooling of hot water is realized in the circulating flow process. It can be understood that the condenser 252, the compressor 253 and the evaporator 254 are matched, so that high-temperature water can be rapidly cooled, and the cooling effect is good.

In some embodiments, as shown in fig. 4, the constant temperature water tank 25 further includes a water reservoir 255 and a water pump 256 provided in the case 251; the reservoir 255 is disposed between the second inlet 22 of the case 251 and the condenser 252, and the second inlet 22, the reservoir 255, the water pump 256, and the condenser 252 are sequentially communicated through pipes. It can be understood that, by providing the water reservoir 255, the high temperature water flowing out from the first outlet 11 of the water cooling head 1 can be stored, and the high temperature water in the water reservoir 255 is sent to the condenser 252 by the water pump 256 to be collected, and when the device to be cooled needs to be cooled, the high temperature water in the water reservoir 255 can be directly sent to the condenser 252 from the water reservoir 255 to be collected, thereby improving the overall cooling efficiency.

In some embodiments, as shown in FIG. 4, thermostatic water tank 25 further includes a control panel 257 disposed on housing 251. It can be understood that, by providing the control panel 257, the control panel 257 can quickly know the temperature and the like in the constant temperature water tank 25, and can control the specific temperature in the constant temperature water tank 25 through the control panel 257.

In some embodiments, as shown in fig. 2 or fig. 4, at least two water cooling heads 1 are provided, at least two water cooling heads 1 are sequentially communicated through a pipeline, the water cooling head 1 at the head end is communicated with the second outlet 21 of the fluid cooling device 2 through a pipeline, and the water cooling head 1 at the tail end is communicated with the second inlet 22 of the fluid cooling device 2 through a pipeline. It should be noted that two adjacent water cooling heads 1 are communicated with each other through a first outlet 11 of one water cooling head 1 and a first inlet 12 of the other water cooling head 1 by a pipeline, so that the low-temperature fluid flowing out from the fluid cooling device 2 through the second outlet 21 flows into the water cooling head 1 at the head end, sequentially flows into the other water cooling heads 1, and then flows out to the fluid cooling device 2 through the water cooling head 1 at the tail end for cooling so as to perform circulation heat dissipation. The at least two water cooling heads 1 are arranged to form a cascade structure, so that the device can be applied to at least two devices to be cooled 20, each device to be cooled corresponds to one water cooling head 1, a plurality of devices to be cooled can be cooled simultaneously, the energy utilization efficiency can be improved, and the cost can be saved; in addition, the refrigeration device 100 is provided with a plurality of water cooling heads 1 to cool a plurality of devices to be cooled simultaneously, so that the volume of the refrigeration device 100 can be reduced, and the noise generated when the refrigeration device 100 operates can be reduced.

Based on the refrigeration apparatus 100, as shown in fig. 1 to 4, the present invention further provides a reagent storage apparatus 1000, the reagent storage apparatus 1000 includes a reagent chamber 200 and the refrigeration apparatus 100, wherein the water cooling head 1 of the refrigeration apparatus 100 is disposed at the bottom of the reagent chamber 200.

In summary, compared with the prior art, the reagent storage device 1000 has at least the following beneficial effects: this reagent storage device 1000 is through setting up reagent storehouse 200, water-cooling head 1 and fluid cooling device 2, wherein water-cooling head 1 sets up in the bottom of reagent storehouse 200, the fluid through fluid cooling device 2 cooling flows into water-cooling head 1, water-cooling head 1 absorbs the heat in reagent storehouse 200 and replaces through the refrigerated fluid that flows into water-cooling head 1, so that reagent storehouse 200 keeps the low temperature state, the fluid after the absorption heat flows into fluid cooling device 2 from water-cooling head 1 and cools off and then gets into water-cooling head 1 once more and circulates, so as to can carry out circulation heat dissipation to reagent storehouse 200, thereby can dispel the heat in order to keep the low temperature state in reagent storehouse 200 fast to reagent storehouse 200, the radiating effect is good. Therefore, the reagent storage device 1000 can omit the use of a TEC module to dissipate heat of the reagent bin 200 by matching the water cooling head 1 with the fluid cooling device 2, and has the characteristics of simple structure, strong heat dissipation, low energy consumption, low damage possibility, low cost and low overall noise.

In some embodiments, the cooling effect is affected due to the fact that a gap between the water cooling head 1 and the reagent bin 200 is easily filled with air. Therefore, the reagent storage device further comprises a heat conducting member (not shown) disposed between the water-cooled head 1 and the reagent chamber 200. It can be understood that, by arranging the heat conducting member between the water cooling head 1 and the reagent chamber 200, the water cooling head 1 and the reagent chamber 200 can be in close contact with each other and can conduct heat, so that the refrigeration effect can be further improved. In this embodiment, the heat conducting member may be a heat conducting gel, which can fill up the gap between the water cooling head 1 and the reagent chamber 200, and can guide the heat of the reagent chamber 200 to the water cooling head 1 for cooling.

In some embodiments, as shown in fig. 1 to 4, around the water cooling head 1, the outer wall of the reagent chamber 200 is provided with a first thermal insulation layer 300, which can effectively insulate external heat, so as to maintain a low temperature state in the reagent chamber 200 and reduce energy consumption.

In some embodiments, the side wall of the water cooling head 1 is formed with a step in the radial direction of the water cooling head 1, and the cross-sectional area of the first end of the water cooling head 1 close to the reagent chamber 200 is smaller than that of the second end; the first insulating layer 300 is disposed on the step. Understandably, by arranging the stepped water-cooling head 1 and arranging the first heat preservation layer 300 on the step of the water-cooling head 1, on one hand, the water-cooling head 1 can continuously refrigerate the reagent bin 200, on the other hand, the contact area between the first heat preservation layer 300 and the reagent bin 200 can be increased, the low-temperature state of the reagent bin 200 is maintained, and the energy consumption is reduced.

In some embodiments, an air blowing device is further disposed in the reagent chamber 200, and it should be noted that, in this embodiment, the air blowing device may be a fan or the like. It can be understood that the air blowing device in the reagent cartridge 200 can cooperate with the refrigerating device 100 to maintain the low temperature state of the reagent cartridge 200; in addition, reagent storehouse 200 is owing to be in the low temperature state, and the reagent in-process of frequently opening reagent storehouse 200 and taking reagent appears the comdenstion water easily, through set up blast apparatus such as fan in reagent storehouse 200, can effectively eliminate the comdenstion water in the reagent storehouse 200, and can accelerate the refrigerating speed of reagent storehouse 200, maintains the low temperature state of reagent storehouse interior 200.

An in vitro diagnostic apparatus comprising the reagent storage device 1000 as described above, as shown in fig. 1 or fig. 7, the reagent storage device 1000 further comprises an incubation chamber 400; it should be noted that the incubation chamber 400 is usually heated to maintain a temperature of 37 ± 0.3 ℃ so as to allow the reagent to be incubated at a constant temperature of 37 ℃.

The incubation cartridge 400 includes a first loop 410 and a second loop 420; the second ring body 420 is sleeved on the first ring body 410 at intervals; the space between the first ring 410 and the second ring 420 forms a flow passage 430, and an inlet and an outlet of the flow passage 430 are communicated with the pipeline between the first outlet 11 of the water cooling head 1 and the second inlet 22 of the fluid cooling device 2 through the pipeline. It can be understood that, by providing the flow channel 430 in the incubation bin 400, an inlet and an outlet of the flow channel 430 are both communicated with a pipeline between the first outlet 11 of the water-cooling head 1 and the second inlet 22 of the fluid cooling device 2, so that a part of the high-temperature fluid coming out from the first outlet 11 of the water-cooling head 1 can flow into the flow channel 430 of the incubation bin 400 and flow out from the outlet of the flow channel 430 of the incubation bin 400 to the fluid cooling device 2 for cooling and circulating flow, and the high-temperature fluid heats the incubation bin 400 to 37 ℃ in the circulating flow process in the flow channel 430 and keeps the incubation bin 400 in a constant temperature state, thereby realizing repeated self-circulation, recycling the waste heat of the system, and achieving the purposes of energy saving and emission reduction.

In some embodiments, as shown in fig. 5 or fig. 6, the in vitro diagnostic apparatus further includes a three-way valve 500 disposed between the first outlet 11 of the water-cooled head 1 and the second inlet 22 of the fluid cooling device 2, and both the incubation chamber 400 and the fluid cooling device 2 are controlled to communicate with the water-cooled head 1 through the three-way valve 500, so that the incubation chamber 400 can be controlled to communicate with the water-cooled head 1 or the fluid cooling device 2 can be controlled to communicate with the water-cooled head 1 according to actual conditions, and the control is flexible.

In some embodiments, as shown in fig. 7, the incubation chamber 400 further includes a third ring 440, the third ring 440 is spaced and sleeved on the second ring 420, and a PI heating film 450 is disposed in a space between the second ring 420 and the third ring 440. It is understood that the PI heating membrane 450 is used to heat the fluid in the flow channel 430 of the incubation chamber 400 for temperature compensation when the temperature of the water in the incubation chamber 400 does not meet the preset requirement.

In some embodiments, as shown in fig. 7, a second insulating layer 460 is disposed between the wall of the incubation cavity 400 and the outer wall of the third ring 440. Understandably, through the arrangement of the second insulating layer 460, external heat can be effectively isolated, so that the low-temperature state in the incubation bin 400 is maintained, and the energy consumption is reduced.

In order to make the technical solutions of the present invention better understood by those skilled in the art, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings.

Embodiment 1 of the refrigeration apparatus 100 of the present invention

As shown in fig. 1, the refrigeration apparatus 100 of the present embodiment includes a water cooling head 1 and a fluid cooling device 2; the fluid cooling device 2 includes a heat exchanger 23 and a heat radiation mechanism 24.

The water cooling head 1 is provided with a first outlet 11 and a first inlet 12; the cold-heat exchanger 23 has a cold end 231 and a hot end 232 connected to the cold end 231, the cold end 231 has a second outlet 21 and a second inlet 22, the second outlet 21 is connected to the first inlet 12 through a pipeline, and the second inlet 22 is connected to the first outlet 11 through a pipeline; the hot end 232 has a third outlet 2321 and a third inlet 2322, the heat dissipation mechanism 24 has a fourth outlet 241 and a fourth inlet 242, the fourth outlet 241 is in communication with the third inlet 2322 through a pipe, and the fourth inlet 242 is in communication with the third outlet 2321 through a pipe.

It can be understood that, through the mutual cooperation of the cold-heat exchanger 23 and the heat dissipation mechanism 24, the heat dissipation mechanism 24 can rapidly cool the fluid, so that the temperature of the fluid is reduced to form a low-temperature fluid which enters the hot end 232 of the cold-heat exchanger 23, the low-temperature fluid is subjected to heat exchange with the fluid at the cold end 231 and then returns to the heat dissipation mechanism 24 to be cooled again to form a circulating flow, the fluid at the cold end 231 can be cooled to form a cooling fluid which enters the water-cooling head 1 to cool the device to be cooled, the characteristic of high refrigeration efficiency can be realized, the device to be cooled, such as the reagent chamber 200, can be effectively ensured to be always in a low-temperature state, and the cold-heat exchanger 23 and the heat dissipation mechanism 24 can be separately installed at positions far away from the device to be cooled according to actual installation needs, and the size of the overall structure can be reduced.

Embodiment 2 of the refrigeration unit 100 of the present invention

As shown in fig. 3, the refrigeration apparatus 100 of the present embodiment includes a water cooling head 1 and a fluid cooling device 2; the fluid cooling device 2 comprises a thermostatic water tank 25.

The water cooling head 1 is provided with a first outlet 11 and a first inlet 12; the constant temperature water tank 25 is provided with a second outlet 21 and a second inlet 22, the second outlet 21 is communicated with the first inlet 12 through a pipeline, the second inlet 22 is communicated with the first outlet 11 through a pipeline, and the water-cooling head 1 and the constant temperature water tank 25 form a loop.

It can be understood that, the constant temperature water tank 25 continuously refrigerates the fluid to form a constant temperature fluid, the constant temperature fluid enters from the first inlet 12 of the water cooling head 1, then exits from the first outlet 11 of the water cooling head 1 and enters the constant temperature water tank 25 from the second inlet 22, in the process, the heat stored in the water cooling head 1 is taken away by the low temperature fluid, the temperature rises, and finally the low temperature fluid enters the constant temperature water tank 25 to flow into the water cooling head 1 again to form a circulation.

When the drawing description is quoted, the new characteristics are explained; in order to avoid that repeated reference to the drawings causes the description to be not concise, the drawings are not referred to one by one in the case of clear description of the described features.

The purpose of the above embodiments is to make an exemplary reproduction and derivation of the technical solutions of the present invention, and to fully describe the technical solutions, objects and effects of the present invention, so as to make the public more thoroughly and comprehensively understand the disclosure of the present invention, and not to limit the protection scope of the present invention.

The above examples are not intended to be exhaustive of the invention and there may be many other embodiments not listed. Any replacement or improvement made without departing from the concept of the present invention shall fall within the protection scope of the present invention.

Claims

1. The in-vitro diagnostic instrument is characterized by comprising a reagent storage device and an incubation bin;

the reagent storage device comprises a reagent bin and a refrigerating device; the refrigerating device comprises a water cooling head and a fluid cooling device; the water cooling head is provided with a first outlet and a first inlet; the fluid cooling device is provided with a second outlet and a second inlet, the second outlet is communicated with the first inlet through a pipeline, the second inlet is communicated with the first outlet through a pipeline, and the water cooling head and the fluid cooling device form a loop; the fluid cooling device comprises a cold heat exchanger and a heat dissipation mechanism; the cold heat exchanger has a cold end and a hot end connected to the cold end, the cold end having the second outlet and the second inlet; the hot end is provided with a third outlet and a third inlet, the heat dissipation mechanism is provided with a fourth outlet and a fourth inlet, the fourth outlet is communicated with the third inlet through a pipeline, the fourth inlet is communicated with the third outlet through a pipeline, the hot end and the heat dissipation mechanism form a loop, and the heat dissipation mechanism is a cooling water tower; the water cooling head is arranged at the bottom of the reagent bin;

2. The in vitro diagnostic apparatus of claim 1, wherein the cold heat exchanger is a plate heat exchanger.

3. The in vitro diagnostic apparatus according to claim 1, wherein the water cooling heads are provided in at least two, at least two of the water cooling heads are in turn in communication via a pipe, the water cooling head at the head end is in communication with the second outlet of the fluid cooling device via a pipe, and the water cooling head at the tail end is in communication with the second inlet of the fluid cooling device via a pipe.

4. The in vitro diagnostic instrument of claim 1, further comprising a thermally conductive member disposed between the water-cooled head and the reagent cartridge.

5. The in vitro diagnostic apparatus according to claim 4, wherein a first heat-insulating layer is disposed on the outer wall of the reagent chamber around the water-cooling head.

6. The in vitro diagnostic apparatus according to claim 5, wherein the side wall of the water cooling head is formed with a step toward the radial direction of the water cooling head, and the cross-sectional area of the water cooling head near the first end of the reagent chamber is smaller than the cross-sectional area of the water cooling head near the second end; the first heat preservation layer is arranged on the step.

7. The in vitro diagnostic apparatus according to claim 1, further comprising a three-way valve disposed between the first outlet of the water-cooling head and the second inlet of the fluid cooling device, wherein the incubation chamber and the fluid cooling device are both in communication with the water-cooling head through the three-way valve.

8. The in vitro diagnostic apparatus of claim 1, wherein the incubation chamber further comprises a third ring body, the third ring body is sleeved on the second ring body at intervals, and a PI heating film is disposed in a space between the second ring body and the third ring body.

9. The in vitro diagnostic apparatus of claim 8, wherein a second layer of insulation is disposed between the wall of the incubation chamber and the outer wall of the third ring.