CN113577561B - Method and device for inducing mental state by microcurrent stimulation - Google Patents

Method and device for inducing mental state by microcurrent stimulation Download PDF

Info

Publication number
CN113577561B
CN113577561B CN202111063279.4A CN202111063279A CN113577561B CN 113577561 B CN113577561 B CN 113577561B CN 202111063279 A CN202111063279 A CN 202111063279A CN 113577561 B CN113577561 B CN 113577561B
Authority
CN
China
Prior art keywords
stimulation
waveform
parameters
user
induction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN202111063279.4A
Other languages
Chinese (zh)
Other versions
CN113577561A (en
Inventor
张曦文
刘庆
凌永权
王淑云
李镇杰
严浩鹏
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Guangdong University of Technology
Original Assignee
Guangdong University of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guangdong University of Technology filed Critical Guangdong University of Technology
Priority to CN202111063279.4A priority Critical patent/CN113577561B/en
Publication of CN113577561A publication Critical patent/CN113577561A/en
Application granted granted Critical
Publication of CN113577561B publication Critical patent/CN113577561B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014External stimulators, e.g. with patch electrodes
    • A61N1/36025External stimulators, e.g. with patch electrodes for treating a mental or cerebral condition
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A61M21/02Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis for inducing sleep or relaxation, e.g. by direct nerve stimulation, hypnosis, analgesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014External stimulators, e.g. with patch electrodes
    • A61N1/3603Control systems
    • A61N1/36031Control systems using physiological parameters for adjustment
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A61M2021/0005Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus
    • A61M2021/0072Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus with application of electrical currents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Psychology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Anesthesiology (AREA)
  • Physiology (AREA)
  • Acoustics & Sound (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Physics & Mathematics (AREA)
  • Child & Adolescent Psychology (AREA)
  • Developmental Disabilities (AREA)
  • Hospice & Palliative Care (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Social Psychology (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

The invention discloses a method and a device for inducing mental states by microcurrent stimulation, wherein the method comprises the following steps: acquiring historical electric stimulation waveform parameters and current human physiological parameters of a user; based on the parameters, basic waveform parameters of the stimulation signals are obtained and optimized, and a combined electric stimulation waveform is synthesized; generating corresponding stimulation micro-current after treatment to induce the mental state of the user; monitoring the induced mental state, obtaining the induced physiological parameters of the human body and recording the accumulated induction duration; setting a stimulation time threshold, and comparing the accumulated induction duration with the stimulation time threshold; if the accumulated induction duration is smaller than the stimulation time threshold, taking the induced human physiological parameter as the current human physiological parameter, repeating the steps, otherwise, ending the mental state induction. The invention designs the specific combined electric stimulation waveforms for different users to carry out the mental induction, and the induction scheme has individual variability, thereby ensuring the real-time performance of the mental induction and improving the induction effect.

Description

Method and device for inducing mental state by microcurrent stimulation
Technical Field
The invention relates to the technical field of medical electronics, in particular to a method and a device for inducing mental states by microcurrent stimulation.
Background
In recent years, noninvasive neuromodulation has been widely used in the scientific research and medical fields as a potential means of physical treatment of neurological and psychiatric disorders. Transcranial electrical stimulation is a non-invasive neuromodulation method for treating or alleviating mental and physical symptoms and studying brain mechanisms by applying electrical current to the head through electrodes of the head in the form of neural stimulation. There have been studies on the use of low-intensity direct or alternating current to study the effects of transcranial electrical stimulation on the brain, including transcranial direct current stimulation, transcranial alternating current stimulation, and transcranial random noise electrical stimulation, which are considered to be essentially painless and can be used to modulate spontaneous neural activity or non-spontaneous neural activity associated with cognitive tasks, causing a more gradual change in neural network. However, the effect of noninvasive nerve regulation has great individual difference, and the meaning of different individuals adopting the same regulation scheme is not great; most of the electric stimulation equipment in the market at present only can realize the key control of current intensity, can not realize the adjustment of electric waveform parameters, but uses the same electric waveform to carry out mental induction on different individuals, and the regulation and control scheme has no individual difference and has poor induction effect.
The Chinese patent application CN109621156A published in 2019, 4 and 16 provides an electroencephalogram feedback type micro-current stimulation sleep-aiding instrument and an application method thereof, wherein the sleep-aiding instrument comprises an electroencephalogram acquisition module, an electroencephalogram analysis module, a human-computer interaction module, a control module and a micro-current stimulation module; the electroencephalogram acquisition module and the electroencephalogram analysis module are used for acquiring and analyzing the electroencephalogram, judging and storing the sleeping state of the user; the control module adjusts the micro-current stimulation module in real time according to the electroencephalogram information acquired by the electroencephalogram acquisition module and the electroencephalogram analysis module, and realizes real-time adjustment of stimulation signals. The method can only realize the control and adjustment of the current intensity, can not design targeted electric waveforms aiming at different individuals, and has poor stimulation effect.
Disclosure of Invention
The invention provides a method and a device for inducing mental states by micro-current stimulation, which can adjust electric waveform parameters according to specific mental conditions of different individuals, synthesize stimulation waveforms with individual variability, output stimulation micro-current corresponding to the stimulation waveforms for mental induction and have good induction effect.
In order to solve the technical problems, the technical scheme of the invention is as follows:
The invention provides a method for inducing mental states by microcurrent stimulation, which comprises the following steps:
s1: acquiring historical electric stimulation waveform parameters and current human physiological parameters of a user;
S2: obtaining basic waveform parameters of the stimulation signals based on the historical electric stimulation waveform parameters and/or the current physiological parameters of the human body;
s3: optimizing basic waveform parameters of the stimulation signals to obtain optimized waveform parameters of the stimulation signals;
S4: synthesizing a combined electrical stimulation waveform according to optimized waveform parameters of the stimulation signal;
s5: processing the combined electrical stimulation waveforms;
S6: generating corresponding stimulation microcurrent according to the processed combined electric stimulation waveform, and inducing the mental state of the user;
S7: monitoring the induced mental state of the user, obtaining the induced physiological parameters of the human body, and recording the accumulated induction duration;
s8: setting a stimulation time threshold, and comparing the accumulated induction duration with the stimulation time threshold; if the accumulated induction duration is less than the stimulation time threshold, taking the induced human physiological parameter as the current human physiological parameter and storing, and repeating the steps S2-S7; otherwise, the mental state induction is ended.
Firstly, acquiring historical electric stimulation waveform parameters of a user and current human physiological parameters, wherein the historical electric stimulation waveform parameters of the user can accurately reflect the induction effect of the historical electric stimulation waveform on the mental condition of the user, and the current human physiological parameters can accurately reflect the current mental condition; according to the historical electric stimulation waveform parameters and the current human physiological parameters of the user, a group of basic waveform parameters of stimulation signals are designed, after the basic waveform parameters are optimized, a combined electric stimulation waveform is synthesized, and the method and the device for inducing the human body physiological parameters by using the combined electric stimulation waveform have the characteristics that the combined electric stimulation waveform with pertinence is designed for different users to conduct mental induction, the induction scheme has individual variability, and the subsequent good induction effect is guaranteed; and processing the combined electric stimulation waveform to generate corresponding stimulation microcurrent so that the stimulation microcurrent meets the requirement of mental induction. The mental state of the user is induced by using the stimulation microcurrent, and the mental state of the user after induction is monitored at the same time, so that the induced human physiological parameters and accumulated induction duration are obtained, the human physiological parameters obtained by real-time monitoring are set as the current human physiological parameters, and are used as the data basis of the basic waveform parameters of the stimulation signals designed at the next moment, thereby ensuring the real-time performance of mental induction and effectively improving the induction effect. The stimulation time threshold is set, and the accumulated induction duration is compared with the stimulation time threshold, so that the condition of stinging discomfort caused by long-time stimulation can be effectively avoided.
Preferably, in the step S1, a current physiological parameter of a human body of a user is obtained by using a physiological measurement method; the physiological measurement method comprises electroencephalogram, electromyogram, nuclear magnetic resonance imaging, heart rate measurement and blood pressure measurement.
Preferably, in the step S2, the specific method for obtaining the basic waveform parameters of the stimulation signal is as follows:
When the user is first induced by mental state, the basic waveform parameters of the stimulation signals are self-defined according to the current physiological parameters of the human body; when the user does not induce the mental state for the first time, selecting historical electric stimulation waveform parameters, and setting basic waveform parameters of stimulation signals by combining current human physiological parameters; the basic waveform parameters of the stimulation signal include amplitude, frequency, phase and duty cycle.
Preferably, in S3, the basic waveform parameters of the stimulation signal are optimized by using an optimization algorithm.
Preferably, in the step S4, the specific method for obtaining the optimized waveform parameters of the stimulation signal is as follows:
for a set of adjustable waveforms, setting a parameter vector z consisting of N amplitude parameters and N frequency parameters; when the adjustable waveform is a sine wave,
When the adjustable waveform is a square wave,
x(t)=sum(ai·square(ωi*t))
z=[a0 a1 … aN-1 ω0 ω1 … ωN-1]T
Where a i denotes the i-th amplitude parameter, ω i denotes the i-th frequency parameter, and t denotes time; a i∈[a0 … aN-1],ωi∈[ω0 … ωN-1];[*]T denotes a transpose operation;
Setting an objective function as follows:
Setting constraint conditions:
|x(t)|≤Amax,max|x(t)|≥Amini≤ωmax
wherein, | 0 represents the l 0 norm, |represents the absolute value operation, a max represents the upper limit of the adjustable waveform peak, a min represents the lower limit of the adjustable waveform peak, and ω max represents the maximum value of the frequency parameter; the value range of omega max is [ omega 0N-1 ];
substitution of l 1 norm for l 0 norm, i.e
The substitution is as follows:
M points are selected from a period of time, constraint conditions are converted into finite constraints, corresponding amplitude parameters and frequency parameters when the parameter vector z takes the lowest latitude are solved, the phase of the waveform is set to be 0, the duty ratio is set to be 50%, and the waveform parameters are jointly used as optimized waveform parameters of the stimulation signals.
Preferably, in the step S5, the specific method for processing the combined electrical stimulation waveform is as follows:
S5.1: converting the combined electrical stimulation waveform into an analog voltage signal;
s5.2: the analog voltage signal is subjected to a filtering operation to remove high frequency components.
Converting the combined electrical stimulation waveform into an analog voltage signal, wherein the positive and negative signals of the analog voltage signal need to have equal maximum amplitude values; the converted analog voltage signal does not need high-frequency components, namely high-frequency electromagnetic interference, and the analog voltage signal needs to be subjected to waveform smoothing to remove high-frequency components.
Preferably, in the step S6, the specific method for inducing the mental state of the user is as follows:
The microcurrent duration t 1 and the pause time t 2 are set, the stimulation microcurrent is applied to the feasible part of the user, and the stimulation microcurrent is alternately performed according to the set duration t 1 and the pause time t 2 to induce the mental state of the user.
The stimulation microcurrent is applied to the user's viable sites, such as the temple or earlobe, and the current stimulation is continued for t 1 minutes, paused for t 2 minutes, continued for t 1 minutes, paused for t 2 minutes, and alternated. Both the duration t 1 and the pause time t 2 may be adjusted based on the user's real-time experience.
Preferably, in S7, the cumulative induction period is a sum of the duration of the micro-current.
The present invention also provides a device for inducing mental states by microcurrent stimulation, the device comprising:
the data acquisition module is used for acquiring historical electric stimulation waveform parameters and current human physiological parameters of a user;
the waveform design module is used for obtaining basic waveform parameters of the stimulation signals according to the historical electric stimulation waveform parameters and/or the current physiological parameters of the human body;
the waveform optimization module is used for optimizing basic waveform parameters of the stimulation signals to obtain optimized waveform parameters of the stimulation signals;
the waveform synthesis module synthesizes a combined electric stimulation waveform according to optimized waveform parameters of the stimulation signals;
The waveform processing module is used for processing the combined electric stimulation waveform;
The discharging module generates corresponding stimulation microcurrent according to the processed combined electric stimulation waveform and induces the mental state of the user;
the state monitoring module is used for monitoring the induced mental state of the user, obtaining the induced brain wave parameters and recording the accumulated induction duration;
The time judging module is used for setting a stimulation time threshold value and comparing the accumulated induction duration with the stimulation time threshold value; if the accumulated induction duration is less than the stimulation time threshold, the induced brain wave parameters are used as the current physiological parameters of the human body, and the waveform design module is returned; otherwise, the mental state induction is ended.
Preferably, the waveform processing module includes:
the digital-to-analog conversion unit is used for converting the combined electric stimulation waveform into an analog voltage signal;
And the filtering unit is used for performing filtering operation on the analog voltage signal and removing high-frequency components.
Compared with the prior art, the technical scheme of the invention has the beneficial effects that:
Firstly, acquiring historical electric stimulation waveform parameters of a user and current human physiological parameters, wherein the historical electric stimulation waveform parameters of the user can accurately reflect the induction effect of the historical electric stimulation waveform on the mental condition of the user, and the current human physiological parameters can accurately reflect the current mental condition; according to the historical electric stimulation waveform parameters and the current human physiological parameters of the user, a group of basic waveform parameters of stimulation signals are designed, after the basic waveform parameters are optimized, a combined electric stimulation waveform is synthesized, and targeted combined electric stimulation waveforms are designed for different users to perform mental induction, and the induction scheme has individual variability, so that the subsequent induction effect is ensured; and processing the combined electric stimulation waveform to generate corresponding stimulation microcurrent so that the stimulation microcurrent meets the requirement of mental induction. The mental state of the user is induced by using the stimulation microcurrent, and the mental state of the user after induction is monitored at the same time, so that the induced human physiological parameters and accumulated induction duration are obtained, the human physiological parameters obtained by real-time monitoring are set as the current human physiological parameters, and are used as the data basis of the basic waveform parameters of the stimulation signals designed at the next moment, thereby ensuring the real-time performance of mental induction and effectively improving the induction effect. The stimulation time threshold is set, and the accumulated induction duration is compared with the stimulation time threshold, so that the condition of stinging discomfort caused by long-time stimulation can be effectively avoided.
Drawings
FIG. 1 is a flow chart of a method for inducing mental states by microcurrent stimulation according to example 1;
FIG. 2 is a combined electrical stimulation waveform of a sine wave synthesis without DC bias addition as described in example 1;
FIG. 3 is a square wave synthesized combined electrical stimulation waveform without DC bias as described in example 1;
FIG. 4 is a combined electrical stimulation waveform of the DC offset added sine wave synthesis described in example 1;
FIG. 5 is a combined electrical stimulation waveform of a square wave synthesis with DC bias added as described in example 1;
fig. 6 is a schematic structural diagram of a device for inducing mental states by microcurrent stimulation according to example 2.
Detailed Description
The drawings are for illustrative purposes only and are not to be construed as limiting the present patent;
For the purpose of better illustrating the embodiments, certain elements of the drawings may be omitted, enlarged or reduced and do not represent the actual product dimensions;
It will be appreciated by those skilled in the art that certain well-known structures in the drawings and descriptions thereof may be omitted.
The technical scheme of the invention is further described below with reference to the accompanying drawings and examples.
Example 1
The present embodiment provides a method for inducing mental states by microcurrent stimulation, as shown in fig. 1, the method comprising:
s1: acquiring historical electric stimulation waveform parameters and current human physiological parameters of a user;
acquiring the current human physiological parameters of a user by using a physiological measurement method; the physiological measurement method comprises electroencephalogram, electromyogram, nuclear magnetic resonance imaging, heart rate measurement and blood pressure measurement.
In this embodiment, the brain state of the user is monitored by using an electroencephalogram measurement device, and the number of brain acquisition channels carried by the electroencephalogram measurement device may be 1,2, 4, 8, 16 or other, and based on the considerations of portability, cost, wearing easiness and the like, the electroencephalogram measurement device with a smaller number of channels is selected to obtain the current brain state data of the user.
S2: obtaining basic waveform parameters of the stimulation signals based on the historical electric stimulation waveform parameters and/or the current physiological parameters of the human body;
When the user is first induced by mental state, the basic waveform parameters of the stimulation signals are self-defined according to the current physiological parameters of the human body; when the user does not induce the mental state for the first time, selecting historical electric stimulation waveform parameters, and setting basic waveform parameters of stimulation signals by combining current human physiological parameters;
For physiological parameters of a human body, electroencephalogram measurement equipment is utilized to obtain electroencephalogram of a user, electroencephalogram components with different frequencies are extracted through fast Fourier transform, and basic waveform parameters of targeted stimulation signals, including amplitude, frequency, phase and duty ratio, are designed by referring to parameter characteristics of different brain wave types; for example, monitoring sleep state, brain wave types related to sleep include delta wave (0.1-3 Hz), theta wave (4-7 Hz), slow alpha wave (8-9 Hz), sigma wave (12-14 Hz), and electroencephalogram is extracted according to brain wave type frequency band division, and basic waveform parameters of stimulation signals are obtained by referring to the parameter characteristics of the current brain wave types.
S3: optimizing basic waveform parameters of the stimulation signals to obtain optimized waveform parameters of the stimulation signals;
the basic waveform parameters of the stimulation signals are optimized by utilizing an optimization algorithm, and the specific method comprises the following steps:
for a set of adjustable waveforms, setting a parameter vector z consisting of N amplitude parameters and N frequency parameters; when the adjustable waveform is a sine wave,
When the adjustable waveform is a square wave,
x(t)=sum(ai·square(ωi*t))
z=[a0 a1 … aN-1 ω0 ω1 … ωN-1]T
Where a i denotes the i-th amplitude parameter, ω i denotes the i-th frequency parameter, and t denotes time; a i∈[a0 … aN-1],ωi∈[ω0 … ωN-1];[*]T denotes a transpose operation;
Setting an objective function as follows:
Setting constraint conditions:
|x(t)|≤Amax,max|x(t)|≥Amini≤ωmax
wherein, | 0 represents the l 0 norm, |represents the absolute value operation, a max represents the upper limit of the adjustable waveform peak, a min represents the lower limit of the adjustable waveform peak, and ω max represents the maximum value of the frequency parameter; the value range of omega max is [ omega 0N-1 ];
substitution of l 1 norm for l 0 norm, i.e
The substitution is as follows:
M points are selected from a period of time, constraint conditions are converted into finite constraints, corresponding amplitude parameters and frequency parameters when the parameter vector z takes the lowest latitude are solved, the phase of the waveform is set to be 0, the duty ratio is set to be 50%, and the waveform parameters are jointly used as optimized waveform parameters of the stimulation signals.
S4: synthesizing a combined electrical stimulation waveform according to optimized waveform parameters of the stimulation signal;
s5: processing the combined electrical stimulation waveforms;
The specific method comprises the following steps:
S5.1: converting the combined electrical stimulation waveform into an analog voltage signal;
s5.2: filtering the analog voltage signal to remove high-frequency components;
Converting the combined electrical stimulation waveform into an analog voltage signal, wherein the positive and negative signals of the analog voltage signal need to have equal maximum amplitude values; the converted analog voltage signal does not need high-frequency components, namely high-frequency electromagnetic interference, and the analog voltage signal needs to be subjected to waveform smoothing to remove high-frequency components.
S6: generating corresponding stimulation microcurrent according to the processed combined electric stimulation waveform, and inducing the mental state of the user;
Specifically, a microcurrent duration t 1 and a pause time t 2 are set, a stimulation microcurrent is applied to a feasible part of a user, and the stimulation microcurrent is alternately performed according to the set duration t 1 and the pause time t 2 to induce the mental state of the user;
In this embodiment, the viable locations for the user are the temples or earlobes; the duration t 1 may be set to 5 minutes, 10 minutes or 15 minutes, adjusted according to the user's real-time experience, and the pause time t 2 is set to 5 minutes.
S7: monitoring the induced mental state of the user, obtaining the induced physiological parameters of the human body, and recording the accumulated induction duration;
the cumulative induction duration is the sum of the duration of the microcurrents.
S8: setting a stimulation time threshold, and comparing the accumulated induction duration with the stimulation time threshold; if the accumulated induction duration is less than the stimulation time threshold, taking the induced human physiological parameter as the current human physiological parameter and storing, and repeating the steps S2-S7; otherwise, the mental state induction is ended.
In a specific implementation process, the embodiment shows that firstly, the historical electric stimulation waveform parameters of the user and the current human physiological parameters are obtained, the historical electric stimulation waveform parameters of the user can accurately reflect the induction effect of the historical electric stimulation waveform on the mental condition of the user, and the current human physiological parameters can accurately reflect the current mental condition; according to the historical electric stimulation waveform parameters and the current human physiological parameters of the user, a group of basic waveform parameters of stimulation signals are designed, after the basic waveform parameters are optimized, a combined electric stimulation waveform is synthesized, and the embodiment designs the combined electric stimulation waveform with pertinence for different users to carry out mental induction, and the induction scheme has individual variability, so that the subsequent induction effect is ensured; and processing the combined electric stimulation waveform to generate corresponding stimulation microcurrent so that the stimulation microcurrent meets the requirement of mental induction. The mental state of the user is induced by using the stimulation microcurrent, and the mental state of the user after induction is monitored at the same time, so that the induced human physiological parameters and accumulated induction duration are obtained, the human physiological parameters obtained by real-time monitoring are set as the current human physiological parameters, and are used as the data basis of the basic waveform parameters of the stimulation signals designed at the next moment, thereby ensuring the real-time performance of mental induction and effectively improving the induction effect. The stimulation time threshold is set, and the accumulated induction duration is compared with the stimulation time threshold, so that the condition of stinging discomfort caused by long-time stimulation can be effectively avoided.
As shown in fig. 2-5, the combined electrical stimulation waveforms synthesized for different individuals in this embodiment are shown; unlike the conventional technology, the conventional technology sets several different common waveforms in advance for the user to select among the waveforms set in advance, and has poor induction effect. The method provided by the embodiment designs and optimizes basic waveform parameters of the stimulation signals according to physiological parameters of a user, synthesizes a combined electric stimulation waveform, and can also add direct current bias to change the combined electric stimulation waveform, wherein the current intensity peak value of the generated stimulation micro-current is generally 0.5mA to 2mA. As shown in fig. 2, a set of combined electrical stimulation waveforms synthesized with sine waves without added dc bias; as shown in fig. 3, a set of square wave synthesized combined electrical stimulation waveforms without added dc bias; as shown in fig. 4, a set of combined electrical stimulation waveforms synthesized with sine waves added with dc bias; as shown in fig. 5, a set of square wave synthesized combined electrical stimulation waveforms with dc bias added. The combined electrical stimulation waveforms synthesized in the present embodiment are not limited to the above combinations, but a group of triangular wave synthesis, sine wave and square wave synthesis, sine wave and triangular wave synthesis, square wave and triangular wave synthesis may be used for each synthesized combined electrical stimulation waveform
Example 2
The present embodiment provides a device for inducing mental states by microcurrent stimulation, as shown in fig. 6, the device comprising:
the data acquisition module is used for acquiring historical electric stimulation waveform parameters and current human physiological parameters of a user;
the waveform design module is used for obtaining basic waveform parameters of the stimulation signals according to the historical electric stimulation waveform parameters and/or the current physiological parameters of the human body;
the waveform optimization module is used for optimizing basic waveform parameters of the stimulation signals to obtain optimized waveform parameters of the stimulation signals;
the waveform synthesis module synthesizes a combined electric stimulation waveform according to optimized waveform parameters of the stimulation signals;
The waveform processing module is used for processing the combined electric stimulation waveform;
The discharging module generates corresponding stimulation microcurrent according to the processed combined electric stimulation waveform and induces the mental state of the user;
the state monitoring module is used for monitoring the induced mental state of the user, obtaining the induced brain wave parameters and recording the accumulated induction duration;
The time judging module is used for setting a stimulation time threshold value and comparing the accumulated induction duration with the stimulation time threshold value; if the accumulated induction duration is less than the stimulation time threshold, the induced brain wave parameters are used as the current physiological parameters of the human body, and the waveform design module is returned; otherwise, the mental state induction is ended.
The waveform processing module includes:
the digital-to-analog conversion unit is used for converting the combined electric stimulation waveform into an analog voltage signal;
And the filtering unit is used for performing filtering operation on the analog voltage signal and removing high-frequency components.
It is to be understood that the above examples of the present invention are provided by way of illustration only and not by way of limitation of the embodiments of the present invention. Other variations or modifications of the above teachings will be apparent to those of ordinary skill in the art. It is not necessary here nor is it exhaustive of all embodiments. Any modification, equivalent replacement, improvement, etc. which come within the spirit and principles of the invention are desired to be protected by the following claims.

Claims (9)

1. A method of inducing a mental state by microcurrent stimulation, the method comprising:
s1: acquiring historical electric stimulation waveform parameters and current human physiological parameters of a user;
S2: obtaining basic waveform parameters of the stimulation signals based on the historical electric stimulation waveform parameters and/or the current physiological parameters of the human body;
s3: the basic waveform parameters of the stimulation signals are optimized, and optimized waveform parameters of the stimulation signals are obtained, wherein the specific method comprises the following steps:
for a set of adjustable waveforms, setting a parameter vector z consisting of N amplitude parameters and N frequency parameters; when the adjustable waveform is a sine wave,
When the adjustable waveform is a square wave,
x(t)=sum(ai·square(ωi*t))
z=[a0 a1…aN-1 ω0 ω1…ωN-1]T
Where a i denotes the i-th amplitude parameter, ω i denotes the i-th frequency parameter, and t denotes time; a i∈[a0…aN-1],ωi∈[ω0…ωN-1];[*]T denotes a transpose operation;
Setting an objective function as follows:
Setting constraint conditions:
|x(t)|≤Amax,max|x(t)|≥Amini≤ωmax
wherein, | 0 represents the l 0 norm, |represents the absolute value operation, a max represents the upper limit of the adjustable waveform peak, a min represents the lower limit of the adjustable waveform peak, and ω max represents the maximum value of the frequency parameter; the value range of omega max is [ omega 0N-1 ];
substitution of l 1 norm for l 0 norm, i.e
The substitution is as follows:
M points are selected from a period of time interval, constraint conditions are converted into finite constraints, corresponding amplitude parameters and frequency parameters when a parameter vector z takes the lowest latitude are solved, the phase of a waveform is set to be 0, the duty ratio is set to be 50%, and the waveform parameters are jointly used as optimized waveform parameters of a stimulation signal;
S4: synthesizing a combined electrical stimulation waveform according to optimized waveform parameters of the stimulation signal;
s5: processing the combined electrical stimulation waveforms;
S6: generating corresponding stimulation microcurrent according to the processed combined electric stimulation waveform, and inducing the mental state of the user;
S7: monitoring the induced mental state of the user, obtaining the induced physiological parameters of the human body, and recording the accumulated induction duration;
s8: setting a stimulation time threshold, and comparing the accumulated induction duration with the stimulation time threshold; if the accumulated induction duration is less than the stimulation time threshold, taking the induced human physiological parameter as the current human physiological parameter and storing, and repeating the steps S2-S7; otherwise, the mental state induction is ended.
2. The method for inducing mental states by micro-current stimulation according to claim 1, wherein in S1, the current physiological parameters of the human body of the user are obtained by using a physiological measurement method; the physiological measurement method comprises electroencephalogram, electromyogram, nuclear magnetic resonance imaging, heart rate measurement and blood pressure measurement.
3. The method for inducing mental states by micro-current stimulation according to claim 1, wherein in S2, the specific method for obtaining basic waveform parameters of the stimulation signal is as follows:
When the user is first induced by mental state, the basic waveform parameters of the stimulation signals are self-defined according to the current physiological parameters of the human body; when the user does not induce the mental state for the first time, selecting historical electric stimulation waveform parameters, and setting basic waveform parameters of stimulation signals by combining current human physiological parameters; the basic waveform parameters of the stimulation signal include amplitude, frequency, phase and duty cycle.
4. The method of inducing mental states by micro-current stimulation according to claim 1, wherein in S3, the basic waveform parameters of the stimulation signal are optimized by using an optimization algorithm.
5. The method for inducing mental states by micro-current stimulation according to claim 1, wherein in S5, the specific method for processing the combined electrical stimulation waveform is as follows:
S5.1: converting the combined electrical stimulation waveform into an analog voltage signal;
s5.2: the analog voltage signal is subjected to a filtering operation to remove high frequency components.
6. The method for inducing mental states by micro-current stimulation according to claim 1, wherein in S6, the specific method for inducing mental states of the user is as follows:
The microcurrent duration t 1 and the pause time t 2 are set, the stimulation microcurrent is applied to the feasible part of the user, and the stimulation microcurrent is alternately performed according to the set duration t 1 and the pause time t 2 to induce the mental state of the user.
7. The method of inducing mental states by microcurrent stimulation according to claim 6, wherein in S7, the cumulative induction period is the sum of microcurrent durations.
8. A device for inducing mental states by microcurrent stimulation, said device comprising:
the data acquisition module is used for acquiring historical electric stimulation waveform parameters and current human physiological parameters of a user;
the waveform design module is used for obtaining basic waveform parameters of the stimulation signals according to the historical electric stimulation waveform parameters and/or the current physiological parameters of the human body;
The waveform optimization module is used for optimizing basic waveform parameters of the stimulation signal to obtain optimized waveform parameters of the stimulation signal, and comprises the following steps:
for a set of adjustable waveforms, setting a parameter vector z consisting of N amplitude parameters and N frequency parameters; when the adjustable waveform is a sine wave,
When the adjustable waveform is a square wave,
x(t)=sum(ai·square(ωi*t))
z=[a0 a1…aN-1 ω0 ω1…ωN-1]T
Where a i denotes the i-th amplitude parameter, ω i denotes the i-th frequency parameter, and t denotes time; a i∈[a0…aN-1],ωi∈[ω0…ωN-1];[*]T denotes a transpose operation;
Setting an objective function as follows:
Setting constraint conditions:
|x(t)|≤Amax,max|x(t)|≥Amini≤ωmax
wherein, | 0 represents the l 0 norm, |represents the absolute value operation, a max represents the upper limit of the adjustable waveform peak, a min represents the lower limit of the adjustable waveform peak, and ω max represents the maximum value of the frequency parameter; the value range of omega max is [ omega 0N-1 ];
substitution of l 1 norm for l 0 norm, i.e
The substitution is as follows:
M points are selected from a period of time interval, constraint conditions are converted into finite constraints, corresponding amplitude parameters and frequency parameters when a parameter vector z takes the lowest latitude are solved, the phase of a waveform is set to be 0, the duty ratio is set to be 50%, and the waveform parameters are jointly used as optimized waveform parameters of a stimulation signal;
the waveform synthesis module synthesizes a combined electric stimulation waveform according to optimized waveform parameters of the stimulation signals;
The waveform processing module is used for processing the combined electric stimulation waveform;
The discharging module generates corresponding stimulation microcurrent according to the processed combined electric stimulation waveform and induces the mental state of the user;
the state monitoring module is used for monitoring the induced mental state of the user, obtaining the induced brain wave parameters and recording the accumulated induction duration;
The time judging module is used for setting a stimulation time threshold value and comparing the accumulated induction duration with the stimulation time threshold value; if the accumulated induction duration is less than the stimulation time threshold, the induced brain wave parameters are used as the current physiological parameters of the human body, and the waveform design module is returned; otherwise, the mental state induction is ended.
9. The apparatus for inducing mental states by microcurrent stimulation according to claim 8, wherein said waveform processing module comprises:
the digital-to-analog conversion unit is used for converting the combined electric stimulation waveform into an analog voltage signal;
And the filtering unit is used for performing filtering operation on the analog voltage signal and removing high-frequency components.
CN202111063279.4A 2021-09-10 2021-09-10 Method and device for inducing mental state by microcurrent stimulation Active CN113577561B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202111063279.4A CN113577561B (en) 2021-09-10 2021-09-10 Method and device for inducing mental state by microcurrent stimulation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202111063279.4A CN113577561B (en) 2021-09-10 2021-09-10 Method and device for inducing mental state by microcurrent stimulation

Publications (2)

Publication Number Publication Date
CN113577561A CN113577561A (en) 2021-11-02
CN113577561B true CN113577561B (en) 2024-06-18

Family

ID=78241851

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202111063279.4A Active CN113577561B (en) 2021-09-10 2021-09-10 Method and device for inducing mental state by microcurrent stimulation

Country Status (1)

Country Link
CN (1) CN113577561B (en)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100496392C (en) * 2007-06-15 2009-06-10 西安电子科技大学 Nerve feedback treating device for insomnia
KR101325368B1 (en) * 2012-04-24 2013-11-08 연세대학교 원주산학협력단 Apparatus for closed-loop electrical brain stimulation using neural response signals
US9782585B2 (en) * 2013-08-27 2017-10-10 Halo Neuro, Inc. Method and system for providing electrical stimulation to a user
CN106474624A (en) * 2016-11-29 2017-03-08 上海交通大学 Electrical transcranial stimulation therapeutic instrument based on Parameter adjustable
JP3217412U (en) * 2018-03-14 2018-08-09 クァン プイトンKwan,Pui Tong Smart composite waveform transcranial electrical stimulation system
CN110585595B (en) * 2019-09-24 2024-02-06 喜临门家具股份有限公司 Transcranial microcurrent stimulation control system based on induced alpha brain waves

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
功能性电刺激恢复周围性面神经麻痹兔眨眼功能的研究;薛玉斌;冯国栋;丁秀勇;赵杨;崔婷婷;高志强;中华耳鼻咽喉头颈外科杂志;20141231;第49卷(第7期);全文 *
用于外周神经的干涉电流刺激器设计;仓臣;丁孝宇;郑政;;中国医学物理学杂志;20200803(第08期);全文 *

Also Published As

Publication number Publication date
CN113577561A (en) 2021-11-02

Similar Documents

Publication Publication Date Title
US20220016423A1 (en) Brain interfacing apparatus and method
US10350410B2 (en) Device and method for effective non-invasive neurostimulation by means of varying stimulus sequences
JP5974116B2 (en) Apparatus for calibrating invasive electrical asynchronous neural stimulation
Delorme et al. EEG changes accompanying learned regulation of 12-Hz EEG activity
US10722711B2 (en) Device for non-invasive neuro-stimulation by means of multichannel bursts
AU2016286517A1 (en) Methods of sensing cross-frequency coupling and neuromodulation
US9808641B2 (en) System and method for non-invasive neuronal stimulation
EP1404216A2 (en) Seizure sensing and detection using an implantable device
CN104951082A (en) Brain-computer interface method for intensifying EEG (electroencephalogram) signals through stochastic resonance
CN109846478A (en) A kind of assessment excitatoty method of cerebral cortex after cranium galvanic current stimulation
CN114733067B (en) Non-implanted multi-target feedback type electric stimulator
CN111481799A (en) Brain wave closed-loop control equipment
Manyakov et al. Decoding SSVEP responses using time domain classification
Wang et al. Incorporating EEG and EMG patterns to evaluate BCI-based long-term motor training
CN109284009B (en) System and method for improving auditory steady-state response brain-computer interface performance
CN113577561B (en) Method and device for inducing mental state by microcurrent stimulation
Li et al. System design of a closed-loop vagus nerve stimulator comprising a wearable eeg recorder and an implantable pulse generator
CN115227263A (en) Neural stimulation system based on EEG signal theta oscillation regulation and control
Hasan et al. A direct noninvasive brain interface with computer based on steady-state visual-evoked potential (SSVEP) with high transfer rates
Zhu et al. When traditional Chinese medicine meets AI: A novel depression treatment paradigm based on transcutaneous vagus nerve stimulation
CN102631192A (en) Deconvolution method for extracting evoked potential at high stimulation ratio
CN203710544U (en) Biofeedback type headache therapeutic device
CN112869755A (en) Electroencephalogram signal feature extraction method based on sphenopalatine ganglion stimulation
CN115363605B (en) Self-adaptive ASSR enhancement device based on high-frequency gamma neural oscillation
Maurer et al. Suppression of neurostimulation artifacts and adaptive clustering of Parkinson's patients behavioral tasks using EEG

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant