CN113577323B - 基于细菌小细胞的生物药物的电离辐射灭菌以及使用方法 - Google Patents

基于细菌小细胞的生物药物的电离辐射灭菌以及使用方法 Download PDF

Info

Publication number
CN113577323B
CN113577323B CN202110761531.2A CN202110761531A CN113577323B CN 113577323 B CN113577323 B CN 113577323B CN 202110761531 A CN202110761531 A CN 202110761531A CN 113577323 B CN113577323 B CN 113577323B
Authority
CN
China
Prior art keywords
minicells
minicell
pharmaceutical composition
bacterial
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN202110761531.2A
Other languages
English (en)
Chinese (zh)
Other versions
CN113577323A (zh
Inventor
马修·J·贾卡罗
加里·H·沃德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vaxiion Therapeutics LLC
Original Assignee
Vaxiion Therapeutics LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vaxiion Therapeutics LLC filed Critical Vaxiion Therapeutics LLC
Priority to CN202110761531.2A priority Critical patent/CN113577323B/zh
Publication of CN113577323A publication Critical patent/CN113577323A/zh
Application granted granted Critical
Publication of CN113577323B publication Critical patent/CN113577323B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0029—Radiation
    • A61L2/0035—Gamma radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/10—Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person
    • A61K41/17—Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person by ultraviolet [UV] or infrared [IR] light, X-rays or gamma rays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/20—Targets to be treated
    • A61L2202/21—Pharmaceuticals, e.g. medicaments, artificial body parts
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
CN202110761531.2A 2015-08-04 2016-08-03 基于细菌小细胞的生物药物的电离辐射灭菌以及使用方法 Active CN113577323B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202110761531.2A CN113577323B (zh) 2015-08-04 2016-08-03 基于细菌小细胞的生物药物的电离辐射灭菌以及使用方法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562200903P 2015-08-04 2015-08-04
US62/200,903 2015-08-04
CN201680053686.8A CN108348624B (zh) 2015-08-04 2016-08-03 基于细菌小细胞的生物药物的电离辐射灭菌以及使用方法
CN202110761531.2A CN113577323B (zh) 2015-08-04 2016-08-03 基于细菌小细胞的生物药物的电离辐射灭菌以及使用方法
PCT/US2016/045400 WO2017024059A1 (en) 2015-08-04 2016-08-03 Ionizing irradiation sterilization of bacterial minicell-based biopharmaceuticals and methods of use

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201680053686.8A Division CN108348624B (zh) 2015-08-04 2016-08-03 基于细菌小细胞的生物药物的电离辐射灭菌以及使用方法

Publications (2)

Publication Number Publication Date
CN113577323A CN113577323A (zh) 2021-11-02
CN113577323B true CN113577323B (zh) 2024-02-20

Family

ID=57943608

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202110761531.2A Active CN113577323B (zh) 2015-08-04 2016-08-03 基于细菌小细胞的生物药物的电离辐射灭菌以及使用方法
CN201680053686.8A Active CN108348624B (zh) 2015-08-04 2016-08-03 基于细菌小细胞的生物药物的电离辐射灭菌以及使用方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201680053686.8A Active CN108348624B (zh) 2015-08-04 2016-08-03 基于细菌小细胞的生物药物的电离辐射灭菌以及使用方法

Country Status (7)

Country Link
US (3) US10124024B2 (enExample)
EP (1) EP3331575A4 (enExample)
JP (2) JP6824960B2 (enExample)
KR (2) KR102558941B1 (enExample)
CN (2) CN113577323B (enExample)
AU (1) AU2016301302B2 (enExample)
WO (1) WO2017024059A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018098163A1 (en) 2016-11-23 2018-05-31 Vaxiion Therapeutics, Llc Immunomodulatory & oncolytic minicells and methods of use
US11624061B2 (en) 2017-04-28 2023-04-11 Agrospheres, Inc. Compositions and methods for enzyme immobilization
US11649265B2 (en) 2017-04-28 2023-05-16 Agrospheres, Inc. Compositions and methods for the encapsulation and scalable delivery of agrochemicals
US11812743B2 (en) 2017-09-25 2023-11-14 Agrospheres, Inc. Compositions and methods for scalable production and delivery of biologicals
US12331320B2 (en) 2018-10-10 2025-06-17 The Research Foundation For The State University Of New York Genome edited cancer cell vaccines
CN110514772A (zh) * 2019-08-09 2019-11-29 中国医学科学院基础医学研究所 透明肾细胞癌代谢标志物在肾细胞癌早期筛查和诊断产品中的应用
US20230044257A1 (en) * 2019-12-23 2023-02-09 Agrospheres, Inc. Compositions and methods for enhanced uptake of active ingredients for animal health and nutrition
WO2021237091A1 (en) * 2020-05-21 2021-11-25 Coherus Biosciences, Inc. Systems and methods for producing sterile injection devices
JPWO2022215495A1 (enExample) * 2021-04-08 2022-10-13
CN117618602A (zh) * 2023-12-18 2024-03-01 苏州尔生生物医药有限公司 一种负载癌细胞裂解物组分的癌症粒子疫苗的终端灭菌方法及其应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5314695A (en) * 1990-11-13 1994-05-24 Corvas International, Inc. Tissue factor based prothrombin time reagent
CN102349978A (zh) * 2011-10-27 2012-02-15 天津中新药业集团股份有限公司达仁堂制药厂 生血丸在制备预防低剂量电离辐射致细胞损伤药物中的应用
WO2012112696A1 (en) * 2011-02-15 2012-08-23 Vaxiion Therapeutics, Inc. Therapeutic compositions and methods for antibody and fc-containing targeting molecule-based targeted delivery of bioactive molecules by bacterial minicells
WO2014055682A1 (en) * 2012-10-02 2014-04-10 Vaxiion Therapeutics, Inc. Immunomodulatory minicells and methods of use
CN104027809A (zh) * 2007-04-08 2014-09-10 免疫之光有限责任公司 治疗细胞增殖性疾病的方法和系统

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58131920A (ja) 1982-01-29 1983-08-06 Nisshin Flour Milling Co Ltd 鶏の大腸菌症の予防法
US4895724A (en) 1985-06-07 1990-01-23 Pfizer Inc. Chitosan compositions for controlled and prolonged release of macromolecules
US5348867A (en) 1991-11-15 1994-09-20 George Georgiou Expression of proteins on bacterial surface
GB9710699D0 (en) 1997-05-24 1997-07-16 Danbiosyst Uk Gastro-retentive controlled release system
WO1999059643A2 (en) 1998-05-20 1999-11-25 Sdg, Inc. Liposomal delivery complex
US7396822B2 (en) 2001-05-24 2008-07-08 Vaxiion Therapeutics, Inc. Immunogenic minicells and methods of use
US20030194798A1 (en) 2001-05-24 2003-10-16 Surber Mark W. Minicell compositions and methods
US20030166099A1 (en) 2001-06-05 2003-09-04 Sabbadini Roger A. Minicells comprising membrane proteins
US20030207833A1 (en) 2002-02-25 2003-11-06 Neil Berkley Pharmaceutical compositions with minicells
ATE502300T1 (de) 2002-12-26 2011-04-15 Nitto Boseki Co Ltd Immunoassay-verfahren
CA2516942A1 (en) * 2003-02-04 2004-08-19 Mcmaster University Use of quinazoline derivatives or other compounds for inhibiting dihydrofolate reduxtase; screening assay for the identification of novel therapeutics and their cellular targets
US7611885B2 (en) 2003-06-24 2009-11-03 Engeneic Molecular Delivery Pty, Ltd. Pharmaceutically compatible method for purifying intact bacterial minicells
AU2004297414C1 (en) 2003-12-09 2009-06-25 Engeneic Molecular Delivery Pty Ltd Targeted gene delivery to non-phagocytic mammalian cells via bacterially derived intact minicells
WO2005058333A1 (de) * 2003-12-18 2005-06-30 Owen Holding Ltd Methode zur gewinnung eines biologisch aktiven mit elektroschock behandelten blutserums und seine verwendung
EP2992901B1 (en) 2004-02-02 2019-10-23 EnGeneIC Molecular Delivery Pty Ltd Compositions and methods for targeted in vitro and in vivo drug delivery to mammalian cells via bacterially derived intact minicells
US8772013B2 (en) 2004-02-02 2014-07-08 Engeneic Molecular Delivery Pty Ltd Methods for targeted in vitro and in vivo drug delivery to mammalian cells via bacterially derived intact minicells
WO2006055024A2 (en) 2004-04-05 2006-05-26 Vaxiion Therapeutics, Inc. Minicells as vaccines
PL2386640T3 (pl) 2004-08-26 2015-08-31 Engeneic Molecular Delivery Pty Ltd Dostarczanie funkcjonalnych kwasów nukleinowych do komórek ssaczych za pośrednictwem nienaruszonych minikomórek pochodzenia bakteryjnego
WO2009012493A2 (en) 2007-07-19 2009-01-22 The Board Of Regents Of The University Of Oklahoma H-antigen binding polypeptides and methods of use
US8236538B2 (en) * 2007-12-20 2012-08-07 Advanced Technologies And Regenerative Medicine, Llc Methods for sterilizing materials containing biologically active agents
CN105483067A (zh) 2008-06-25 2016-04-13 瓦克星治疗有限责任公司 可调型基因自杀机制组合物和方法
EP2356235A1 (en) 2008-11-14 2011-08-17 Marina Biotech, Inc. E. coli mediated gene silencing of beta-catenin
WO2018098163A1 (en) * 2016-11-23 2018-05-31 Vaxiion Therapeutics, Llc Immunomodulatory & oncolytic minicells and methods of use

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5314695A (en) * 1990-11-13 1994-05-24 Corvas International, Inc. Tissue factor based prothrombin time reagent
CN104027809A (zh) * 2007-04-08 2014-09-10 免疫之光有限责任公司 治疗细胞增殖性疾病的方法和系统
WO2012112696A1 (en) * 2011-02-15 2012-08-23 Vaxiion Therapeutics, Inc. Therapeutic compositions and methods for antibody and fc-containing targeting molecule-based targeted delivery of bioactive molecules by bacterial minicells
CN102349978A (zh) * 2011-10-27 2012-02-15 天津中新药业集团股份有限公司达仁堂制药厂 生血丸在制备预防低剂量电离辐射致细胞损伤药物中的应用
WO2014055682A1 (en) * 2012-10-02 2014-04-10 Vaxiion Therapeutics, Inc. Immunomodulatory minicells and methods of use

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
《军事医学》编辑委员会.电离辐射.《中国医学百科全书 军事医学》.上海科学技术出版社,1995,(第1版),第820-821页. *
何小维 等.海藻糖.《碳水化合物功能材料》.中国轻工业出版社,2007,(第1版),第372-373页. *

Also Published As

Publication number Publication date
CN108348624B (zh) 2021-07-27
WO2017024059A8 (en) 2017-06-29
JP7568519B2 (ja) 2024-10-16
KR102558941B1 (ko) 2023-07-21
KR20230111275A (ko) 2023-07-25
AU2016301302A1 (en) 2018-03-08
EP3331575A1 (en) 2018-06-13
US20180153942A1 (en) 2018-06-07
JP2018522036A (ja) 2018-08-09
KR102687638B1 (ko) 2024-07-22
KR20180056642A (ko) 2018-05-29
US10124024B2 (en) 2018-11-13
US20230321159A1 (en) 2023-10-12
US12427172B2 (en) 2025-09-30
JP6824960B2 (ja) 2021-02-03
CN113577323A (zh) 2021-11-02
CN108348624A (zh) 2018-07-31
AU2016301302B2 (en) 2023-01-12
WO2017024059A1 (en) 2017-02-09
US20190282629A1 (en) 2019-09-19
US11564953B2 (en) 2023-01-31
EP3331575A4 (en) 2019-03-27
JP2021059600A (ja) 2021-04-15

Similar Documents

Publication Publication Date Title
US12427172B2 (en) Ionizing irradiation sterilization of bacterial minicell-based biopharmaceuticals and methods of use
US10919942B2 (en) Therapeutic compositions and methods for antibody and Fc-containing targeting molecule-based targeted delivery of bioactive molecules by bacterial minicells
US20220054585A1 (en) Immunomodulatory & oncolytic minicells and methods of use
US20250339518A1 (en) Dual sting/rig-i agonist oncolytic minicells as in situ immunization agents and methods of use

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant