CN113577193A

CN113577193A - Oral liquid for improving immunity of patients and production process thereof

Info

Publication number: CN113577193A
Application number: CN202110899761.5A
Authority: CN
Inventors: 刘学义
Original assignee: Individual
Current assignee: Individual
Priority date: 2021-08-06
Filing date: 2021-08-06
Publication date: 2021-11-02

Abstract

The invention relates to the technical field of traditional Chinese medicine oral liquid, and discloses an oral liquid for improving immunity of a patient and a production process thereof, wherein the oral liquid is prepared from the following raw materials, by weight, 40-45 parts of astragalus, 30-35 parts of bighead atractylodes rhizome, 15-20 parts of angelica sinensis, 10-15 parts of divaricate saposhnikovia root, 20-25 parts of eucommia male flower, 8-13 parts of rhizoma polygonati, 8-13 parts of pulp of dogwood fruit, 7-12 parts of dandelion and 7-12 parts of fructus forsythiae, or prepared from the following raw materials, by weight, 42 parts of astragalus, 33 parts of bighead atractylodes rhizome, 17 parts of angelica sinensis, 13 parts of radix saposhnikoviae, 23 parts of eucommia male flower, 10 parts of rhizoma polygonati, 10 parts of pulp of dogwood fruit, 9 parts of dandelion and 9 parts of fructus forsythiae. The oral liquid for improving the immunity of patients and the production process thereof can effectively clean dust and impurities on the surface of the raw material medicine, avoid the waste of medicine components in the traditional washing process, can respectively extract the effective components of the raw material medicine, and avoid the damage of the medicine components due to excessive boiling.

Description

Oral liquid for improving immunity of patients and production process thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicine oral liquid, in particular to oral liquid for improving the immunity of patients and a production process thereof.

Background

The oral liquid is a sterile or semi-sterile oral liquid preparation prepared by taking traditional Chinese medicine decoction as a basis, extracting active ingredients from the medicine, adding additives such as a flavoring agent, an antibacterial agent and the like, and filling and sealing the injection ampoule, so the oral liquid is also called an oral ampoule preparation, is a novel preparation combining three dosage forms of decoction, syrup and injection, such as Shengmaiyin oral liquid, Sirentang oral liquid, Shenronghuanghuang royal jelly oral liquid and the like, and is characterized by small administration dosage, good taste, quick absorption, quick effect taking and easy acceptance by patients, and the curative effect of the prepared oral liquid is different according to different prescriptions, such as astragalus root, qi replenishing and consolidating superficial resistance of patients, bighead atractylodes rhizome, spleen invigorating and strengthening body resistance to assist in the micro absorption and transportation of cereal essence, so that water and kidney are converted into qi and blood, body surface bones of four limbs are nourished, and the astragalus root, the bighead atractylodes rhizome, the spleen invigorating, qi replenishing and consolidating body, improving the vital qi and disease resistance of human body. Preventing invasion and invasion, improving immunity, and preventing common cold, pneumonia and postoperative regulation of various tumors.

At present, when active ingredients in raw material medicines are extracted from traditional Chinese medicine oral liquid, impurity removal and dust removal of the raw material medicines are a particularly important step, otherwise dust and impurities on the surfaces of the raw material medicines can be doped in the active ingredients of the medicines, difficulty in subsequent refining of the traditional Chinese medicine oral liquid is increased, however, the active ingredients of the medicinal materials can be lost during traditional water washing, the speed of medicine precipitation is also influenced by structural compactness of different raw material medicines, and more medicine ingredients can be remained in part of medicine residues.

Disclosure of Invention

Technical problem to be solved

Aiming at the defects of the prior art, the invention provides the oral liquid for improving the immunity of the patient and the production process thereof, which can effectively clean dust and impurities on the surface of the raw material medicine, avoid the waste of medicine components in the traditional washing process, respectively extract the effective components of the raw material medicine, avoid the damage of the medicine components due to excessive boiling, and solve the problems that the dust and the impurities on the surface of the raw material medicine are mixed in the effective components of the medicine, the difficulty in the subsequent refining of the traditional Chinese medicine oral liquid is increased, the effective components of the medicinal materials are lost in the traditional washing process, the speed of medicine precipitation is influenced by the structural compactness of different raw material medicines, and more medicine components are remained in partial medicine residues.

(II) technical scheme

In order to achieve the purpose, the invention provides the following technical scheme: the oral liquid for improving the immunity of a patient is prepared from the following raw material medicines in parts by weight:

40-45 parts of astragalus membranaceus, 30-35 parts of bighead atractylodes rhizome, 15-20 parts of angelica sinensis, 10-15 parts of divaricate saposhnikovia root, 20-25 parts of eucommia ulmoides male flower, 8-13 parts of rhizoma polygonati, 8-13 parts of cornus officinalis, 7-12 parts of dandelion and 7-12 parts of fructus forsythiae.

Preferably, the oral liquid is prepared from the following raw material medicines in parts by weight:

42 parts of astragalus, 33 parts of bighead atractylodes rhizome, 17 parts of angelica, 13 parts of divaricate saposhnikovia root, 23 parts of eucommia male flower, 10 parts of rhizoma polygonati, 10 parts of cornus officinalis, 9 parts of dandelion and 9 parts of fructus forsythiae.

Prescription solution, monarch drug: astragalus membranaceus and Astragalus membranaceus have the effects of invigorating qi, consolidating superficial resistance, expelling toxin, expelling pus, promoting urination and promoting granulation, and can be used for treating qi deficiency, debilitation, chronic diarrhea, rectocele, spontaneous perspiration, edema and unhealed wound, and have sweet taste, mild nature and spleen and lung channel tropism;

ministerial drugs: the white atractylodes rhizome, the divaricate saposhnikovia root and the eucommia male flower have the effects of strengthening spleen and body resistance, assisting in the micro absorption and transportation of paddy essence, converting hydronephrosis into qi and blood, nourishing the four limbs and bones of a body, matching the astragalus and the white atractylodes rhizome to strengthen spleen and replenish qi to consolidate the constitution, improving the body healthy qi and disease resistance of a human body, being pungent and sweet in taste and warm in nature, having the effects of relieving exterior syndrome and sweating, dispelling wind and eliminating dampness, mainly treating wind-cold type cold, headache, fever, arthralgia and tetanus, matching the astragalus with the divaricate saposhnikovia root to consolidate the exterior without leaving, walking out the exterior and expelling pathogenic factors if the radix sileris is used, not damaging the qi, having the effects of replenishing qi, dispelling wind and consolidating the constitution if the astragalus, improving the immunity, tranquilizing and hypnotizing, and resisting aging and resisting oxidation and inhibiting bacteria;

adjuvant drugs: rhizoma Polygonati, radix Angelicae sinensis and Corni fructus, rhizoma Polygonati, is sweet in taste, neutral in nature, and has effects of invigorating qi, nourishing yin, invigorating spleen, moistening lung, invigorating kidney, replenishing blood, promoting blood circulation, moistening dryness, and smoothing intestine;

a messenger drug: dandelion and forsythia, dandelion is bitter and sweet in taste, cold in nature, enters liver and stomach channels to clear heat and remove toxicity, and forsythia is bitter in taste, cold in nature, enters heart, liver and gallbladder channels to clear heat, remove toxicity, dissipate stagnation and reduce swelling.

The invention also provides a production process of the oral liquid for improving the immunity of patients, which comprises the following steps;

step one, raw material medicinal materials are classified, wherein weighed astragalus, bighead atractylodes rhizome, angelica sinensis, divaricate saposhnikovia root, weeping forsythia and rhizoma polygonati are mixed for later use, and eucommia male flowers, dandelion and dogwood fruit are mixed for later use;

step two, cleaning the medicinal materials, namely cleaning the medicinal materials classified in the step one by adopting an air separation device;

step three, preparing the medicine, namely extracting the components of the traditional Chinese medicine in the step two by adopting a common traditional Chinese medicine extraction method, mixing the liquid medicine obtained by two extractions, and standing to enable the liquid medicine to naturally settle;

step four, liquid medicine treatment, namely juicing the liquid medicine obtained in the step three, removing residues, filtering the taken liquid medicine in an ultrafiltration device, and concentrating the liquid medicine after filtering;

and step five, blending and refining, namely selecting a flavoring agent and a preservative which are allowed to be used in medicine to blend the concentrated solution in the step four, selecting a proper fine filter to filter impurities in the liquid medicine again after blending, and finally performing sterile subpackage and storage.

Preferably, the traditional Chinese medicine extraction method adopted in the third step is a water decoction method and a supercritical fluid extraction method, the medicinal ingredients in the raw material medicines are extracted by water decoction, when the water decoction is carried out, the eucommia male flowers, the dandelion and the dogwood pulp are prepared into medicine bags and put into a decocting pot, after the decoction is finished, the medicine juice in the decocting pot is taken out, the medicine bag is taken out, the rest astragalus, the bighead atractylodes rhizome, the angelica, the divaricate saposhnikovia root, the weeping forsythia and the rhizoma polygonati are naturally cooled and dried, and the surface moisture is extracted for the second time by using the supercritical fluid extraction method.

Preferably, when the medicine bag is manufactured, the stainless steel filter basket is used for containing the raw material medicines, so that eucommia male flowers, dandelion and dogwood fruit can be placed in a whole manner, when the raw material medicines are decocted by a water decoction method, normal-temperature water is added to soak astragalus mongholicus, bighead atractylodes rhizome, angelica sinensis, divaricate saposhnikovia roots, fructus forsythiae and rhizoma polygonati at regular time, then the eucommia male flowers, the dandelion and the dogwood fruit placed in the stainless steel filter basket are added to soak together, then the regular and quantitative decoction is started, the decoction is alternately decocted by mild and strong fire until the decoction is discolored, the decoction is taken by turning off the fire, and the decoction is repeated.

Preferably, normal temperature water is added in the boiling process, the water amount is 2.5-3.5 times of that of the raw material medicines when the raw material medicines are soaked for the first time, the water amount is 1-1.3 times of that of the raw material medicines when the raw material medicines are decocted for the second time and the third time, and eucommia male flowers, dandelion and dogwood fruit pulp are taken out before the three times of boiling, and the medicine juice is drained when the eucommia male flowers, the dandelion and the dogwood fruit pulp are taken out.

The invention also provides a winnowing device used in the production process of oral liquid, which comprises a tank body and a frame, wherein one end of the tank body is provided with an opening, the opening is fixedly connected with a sealing plate through a lock catch, the center of the sealing plate is fixedly connected with an air inlet pipe through a round hole, a grid plate is fixedly connected in the air inlet pipe, the side wall of the tank body is sleeved with an annular block, the inner side of the annular block is provided with an installation groove with an annular structure, the installation groove is connected with a transmission mechanism, the upper end of the frame is fixedly connected with two support rods, the side wall of one support rod is rotatably connected with a transverse pipe through a first rolling bearing, one end of the transverse pipe is fixedly connected with one side of the annular block, the other end of the transverse pipe penetrates through a first rolling bearing and is fixedly connected with a rotary joint, the side wall of the other support rod is rotatably connected with a rotating shaft through a third rolling bearing, the one end of pivot is rotated through the lateral wall of first ball bearing and annular piece and is connected, the lateral wall of the jar body runs through the exhaust hole of having seted up a plurality of evenly distributed, two rubber rings, two have been cup jointed to the lateral wall of the jar body the rubber ring all with the inboard fixed connection of annular piece.

Preferably, drive mechanism includes the ring, the inboard of ring and the lateral wall fixed connection of the jar body, the bevel face has all been seted up to two edges and corners in the outside of ring, the ring has a plurality of evenly distributed's first bevel gear through two bevel face engagements, one side fixedly connected with rotation axis of first bevel gear, the one end of rotation axis is passed through fourth antifriction bearing and is connected with the lateral wall rotation of mounting groove, the upper end fixedly connected with gear motor of ring shape piece, gear motor's output runs through the lateral wall and the fixedly connected with second bevel gear of ring shape piece, and second bevel gear and the meshing of first bevel gear.

Preferably, the upper end fixedly connected with connecting piece of bracing piece, the connecting piece rotates through the connecting hole and is connected with the pivot, one side fixedly connected with locating piece of pivot, the one end of pivot is passed third antifriction bearing and has been seted up the right angle breach, locating piece and right angle breach joint, the one end fixedly connected with flexure strip of pivot, one side fixedly connected with fixture block of connecting piece, fixedly connected with ring gear on the axle wall of pivot, one side meshing of ring gear has the gear, the one end of rotation axis pass fourth antifriction bearing and with one side fixed connection of gear.

Preferably, the lower extreme center department of the jar body is connected with the locating lever through the rotation of second ball bearing, a plurality of evenly distributed's of symmetry fixedly connected with pin on the pole wall of locating lever, the lower extreme fixedly connected with U type frame of locating lever, two vertical portion upper ends of U type frame all are connected with the lower extreme fixed connection of annular piece, a plurality of spoilers of the inboard fixedly connected with of the jar body, wherein adjacent two equal fixedly connected with separates the net between the spoiler, and separates one side of net and the inner wall fixed connection of the jar body, a plurality of supporting wheels of the equal fixedly connected with in upper and lower both ends of annular piece, it is a plurality of the supporting wheel all contacts with the lateral wall of the jar body.

(III) advantageous effects

Compared with the prior art, the invention provides the oral liquid for improving the immunity of patients and the production process thereof, and the oral liquid has the following beneficial effects:

1. this improve production technology of patient's immunity oral liquid when stewing the bulk drug, according to the closely knit degree difference of structure, classify the bulk drug in the prescription, at first soak the closely knit bulk drug of structure to in time taking out the medicinal material of the structure flaccidity when stewing, avoid stewing the process of stewing chinese-medicinal material structure and destroyed, produce more impurity and influence the refined extract in later stage, be difficult for destroying pharmaceutical composition because of excessive stewing moreover.

2. Still be equipped with wind selector among this improve patient's immunity oral liquid's the production technology, this wind selector drives second bevel gear rotatory through gear motor, it is rotatory to drive first bevel gear when second bevel gear is rotatory, first bevel gear is rotatory to drive the ring rotatory with the cooperation of awl tooth face, the ring rotation drives jar body and rotates along its axial, because locating lever and pin are fixed motionless, consequently jar body drives its inside bulk drug and is stirred when rotatory, use air-bleed equipment to connect quick-operation joint, outside air enters into jar internal through the intake pipe, jar internal gas passes and separates the net and the exhaust hole enters into violently the pipe, then take out by outside air-bleed equipment, and then can discharge dust and piece when stirring the bulk drug.

3. This improve wind selector in patient's immunity oral liquid's production technology, can also be with locating piece and the epaxial right angle breach joint of commentaries on classics when using, the pivot is unable rotatory this moment, the gear receives the transmission power effect of transmission shaft and rolls on the ring gear surface, use positive and negative rotation controller control gear motor to be positive and negative rotary motion, therefore gear motor can drive mechanism and make the jar body along the reciprocal swing of axis of violently managing and pivot, also do reciprocal rotation along the central line of annular piece simultaneously, and can be at the spoiler, make the internal bulk drug of jar strike each other under the effect of locating lever and pin, the surperficial dust and the piece of bulk drug are clear away to the high efficiency, the degree of difficulty of later stage refined bulk drug extract has been reduced.

Drawings

FIG. 1 is a schematic structural diagram of an air separation device used in a process for producing oral liquid for improving immunity of patients according to the present invention;

FIG. 2 is a partial cross-sectional view of FIG. 1;

FIG. 3 is a schematic view showing the internal structure of the can body of FIG. 2;

FIG. 4 is a schematic structural view of the rotating shaft, the positioning block and the connecting member shown in FIG. 1;

FIG. 5 is an enlarged view of the structure at A in FIG. 2;

fig. 6 is an enlarged view of the structure at B in fig. 2.

In the figure: 1. a ring block; 2. a tank body; 3. a sealing plate; 4. an air inlet pipe; 5. a grid plate; 6. a support wheel; 7. a support bar; 8. positioning blocks; 9. a frame; 10. a U-shaped frame; 11. a spoiler; 12. a stop lever; 13. positioning a rod; 14. a circular ring; 15. a first bevel gear; 16. a reduction motor; 17. separating the net; 18. A rotating shaft; 19. positioning blocks; 20. a connecting member; 21. an elastic sheet; 22. a clamping block; 23. a second bevel gear; 24. a rubber ring; 25. a gear; 26. a ring gear.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Example 1:

an oral liquid for improving immunity of a patient is prepared by weighing 40 parts of astragalus, 30 parts of bighead atractylodes rhizome, 15 parts of angelica, 10 parts of divaricate saposhnikovia root, 20 parts of eucommia male flower, 8 parts of rhizoma polygonati, 8 parts of cornus officinalis, 7 parts of dandelion and 7 parts of fructus forsythiae in parts by weight, and extracting medicinal components by adopting the following method;

step three, medicine preparation, namely extracting the components of the raw materials in the step two by two times by adopting a common traditional Chinese medicine extraction method, mixing the liquid medicines obtained by two times of extraction, standing to enable the liquid medicine to naturally settle, wherein the adopted traditional Chinese medicine extraction method comprises a water decoction method and a supercritical fluid extraction method, firstly decocting the components of the raw materials by water, preparing the eucommia male flower, the dandelion and the dogwood fruit into a medicine bag when decocting the components by water, putting the medicine bag into a decocting pot, taking out the medicine juice in the decocting pot after the decoction is finished, taking out the medicine bag, naturally cooling the rest astragalus, the bighead atractylodes rhizome, the angelica, the divaricate saposhnikovia root, the weeping forsythia and the sealwort and drying the surface water, and carrying out secondary extraction on the medicine residues by using the supercritical fluid extraction method; when the medicine bag is manufactured, the stainless steel filter basket is used for containing raw material medicines, so that eucommia male flowers, dandelion and dogwood pulp can be placed in a whole and taken, when the raw material medicines are decocted by a water decoction method, normal-temperature water is added to soak astragalus membranaceus, bighead atractylodes rhizome, angelica sinensis, wind-proof fructus forsythiae and polygonatum sibiricum for 2 hours at regular time, then the eucommia male flowers, the dandelion and the dogwood pulp placed in the stainless steel filter basket are added to soak for 2 hours together, then the decoction is started for 2 hours at regular time and quantitatively, the decoction is alternately decocted by mild and strong fire until the decoction discolors, the decoction is taken by turning off the fire, the decoction is repeated, the normal-temperature water in an amount which is 2.5 times that of the raw material medicines is added in the decocting process, the water amount is 2.5 times that of the raw material medicines is soaked for the first time, the water amount is 1 time that of the raw material medicines is decocted for the second time, the eucommia male flowers, the dandelion and the dogwood pulp are taken out before the decoction is carried out, and the decoction is carried out until the decoction is carried out.

Example 2: the difference is based on example 1;

an oral liquid for improving immunity of a patient is prepared by weighing 41 parts of astragalus, 31 parts of bighead atractylodes rhizome, 16 parts of angelica, 11 parts of divaricate saposhnikovia root, 21 parts of eucommia male flower, 9 parts of rhizoma polygonati, 9 parts of cornus officinalis, 8 parts of dandelion and 8 parts of fructus forsythiae in parts by weight, and extracting medicinal components by adopting the following method;

step three, medicine preparation, namely extracting the components of the raw materials in the step two by two times by adopting a common traditional Chinese medicine extraction method, mixing the liquid medicines obtained by two times of extraction, standing to enable the liquid medicine to naturally settle, wherein the adopted traditional Chinese medicine extraction method comprises a water decoction method and a supercritical fluid extraction method, firstly decocting the components of the raw materials by water, preparing the eucommia male flower, the dandelion and the dogwood fruit into a medicine bag when decocting the components by water, putting the medicine bag into a decocting pot, taking out the medicine juice in the decocting pot after the decoction is finished, taking out the medicine bag, naturally cooling the rest astragalus, the bighead atractylodes rhizome, the angelica, the divaricate saposhnikovia root, the weeping forsythia and the sealwort and drying the surface water, and carrying out secondary extraction on the medicine residues by using the supercritical fluid extraction method; when the raw material medicines are decocted by a water decoction method, normal-temperature water is added to soak astragalus membranaceus, bighead atractylodes rhizome, angelica sinensis, wind-proof fructus forsythiae and rhizoma polygonati for 2.2 hours at regular time, then the eucommia staminate flowers, dandelion and the fructus corni placed in the stainless steel filter basket are added to soak the astragalus membranaceus, the bighead atractylodes rhizome, the angelica sinensis, the fructus forsythiae and the rhizoma polygonati for 2.2 hours together, then the decoction is started for 2.2 hours at regular time and in fixed quantity, the decoction is carried out alternately by mild fire and strong fire until the decoction turns color, the decoction is taken by turning off the fire, the decoction is repeated, the normal-temperature water which is 2.8 times of the raw material medicines is added in the decoction process, the water amount is 2.7 times of the raw material medicines when the raw material medicines are soaked for the first time, the water amount is 1.1 time of the raw material medicines when the decoction is carried out for the second time, the eucommia staminate flowers, the dandelion and the fructus corni are taken out before the decoction for the third time, and the decoction is carried out, and the decoction is drained.

Example 3: the difference is based on example 1;

an oral liquid for improving immunity of a patient is prepared by weighing 42 parts of astragalus, 32 parts of bighead atractylodes rhizome, 17 parts of angelica, 12 parts of divaricate saposhnikovia root, 22 parts of eucommia male flower, 10 parts of rhizoma polygonati, 10 parts of cornus officinalis, 9 parts of dandelion and 9 parts of fructus forsythiae in parts by weight, and extracting medicinal components by adopting the following method;

step three, medicine preparation, namely extracting the components of the raw materials in the step two by two times by adopting a common traditional Chinese medicine extraction method, mixing the liquid medicines obtained by two times of extraction, standing to enable the liquid medicine to naturally settle, wherein the adopted traditional Chinese medicine extraction method comprises a water decoction method and a supercritical fluid extraction method, firstly decocting the components of the raw materials by water, preparing the eucommia male flower, the dandelion and the dogwood fruit into a medicine bag when decocting the components by water, putting the medicine bag into a decocting pot, taking out the medicine juice in the decocting pot after the decoction is finished, taking out the medicine bag, naturally cooling the rest astragalus, the bighead atractylodes rhizome, the angelica, the divaricate saposhnikovia root, the weeping forsythia and the sealwort and drying the surface water, and carrying out secondary extraction on the medicine residues by using the supercritical fluid extraction method; when the raw material medicines are decocted by a water decoction method, normal-temperature water is added to soak astragalus membranaceus, bighead atractylodes rhizome, angelica sinensis, wind-proof fructus forsythiae and rhizoma polygonati for 2.3 hours at regular time, then the eucommia staminate flowers, dandelion and the fructus corni placed in the stainless steel filter basket are added to soak the astragalus membranaceus, the bighead atractylodes rhizome, the angelica sinensis, the fructus forsythiae and the rhizoma polygonati for 2.3 hours together, then the decoction is started for 2.3 hours at regular time and in a quantitative mode, the decoction is carried out alternately by mild fire and strong fire until the decoction turns color, the decoction is taken by turning off the fire, the decoction is repeated, the normal-temperature water is added in the decocting process, the water amount is 2.8 times of the raw material medicines when the raw material medicines are soaked for the first time, the water amount is 1.2 times of the raw material medicines when the raw material medicines are decocted for the second time, the eucommia staminate flowers, the dandelion and the fructus corni are taken out before the decoction is carried out, and the decoction is drained.

Example 4: the difference is based on example 1;

an oral liquid for improving immunity of a patient is prepared by weighing 43 parts of astragalus root, 33 parts of white atractylodes rhizome, 18 parts of angelica, 13 parts of divaricate saposhnikovia root, 23 parts of eucommia male flower, 11 parts of rhizoma polygonati, 11 parts of cornus fruit, 10 parts of dandelion and 10 parts of fructus forsythiae by weight, and extracting medicinal components by adopting the following method;

step three, medicine preparation, namely extracting the components of the raw materials in the step two by two times by adopting a common traditional Chinese medicine extraction method, mixing the liquid medicines obtained by two times of extraction, standing to enable the liquid medicine to naturally settle, wherein the adopted traditional Chinese medicine extraction method comprises a water decoction method and a supercritical fluid extraction method, firstly decocting the components of the raw materials by water, preparing the eucommia male flower, the dandelion and the dogwood fruit into a medicine bag when decocting the components by water, putting the medicine bag into a decocting pot, taking out the medicine juice in the decocting pot after the decoction is finished, taking out the medicine bag, naturally cooling the rest astragalus, the bighead atractylodes rhizome, the angelica, the divaricate saposhnikovia root, the weeping forsythia and the sealwort and drying the surface water, and carrying out secondary extraction on the medicine residues by using the supercritical fluid extraction method; when the raw material medicines are decocted by a water decoction method, normal-temperature water is added to soak astragalus membranaceus, bighead atractylodes rhizome, angelica sinensis, wind-proof fructus forsythiae and rhizoma polygonati for 2.5 hours at regular time, then the eucommia staminate flowers, dandelion and the fructus corni placed in the stainless steel filter basket are added to soak the astragalus membranaceus, the bighead atractylodes rhizome, the angelica sinensis, the fructus forsythiae and the rhizoma polygonati for 2.5 hours together, then the decoction is started for 2.5 hours at regular time and in a quantitative mode, the decoction is carried out alternately by slow fire and strong fire until the decoction changes color, the decoction is taken by turning off the fire, the decoction is repeated, the normal-temperature water is added in the decocting process, the water amount is 3 times of the raw material medicines when the raw material medicines are soaked for the first time, the water amount is 1.3 times of the raw material medicines when the raw material medicines are decocted for the second time, the eucommia staminate flowers, the dandelion and the fructus corni are taken out before the decoction is carried out for the third time, and the decoction is carried out, and the decoction is drained.

Example 5: the difference is based on example 1;

an oral liquid for improving immunity of a patient is prepared by weighing 44 parts of astragalus, 34 parts of bighead atractylodes rhizome, 19 parts of angelica, 14 parts of divaricate saposhnikovia root, 24 parts of eucommia male flower, 12 parts of rhizoma polygonati, 12 parts of cornus officinalis, 11 parts of dandelion and 11 parts of fructus forsythiae in parts by weight, and extracting medicinal components by adopting the following method;

step three, medicine preparation, namely extracting the components of the raw materials in the step two by two times by adopting a common traditional Chinese medicine extraction method, mixing the liquid medicines obtained by two times of extraction, standing to enable the liquid medicine to naturally settle, wherein the adopted traditional Chinese medicine extraction method comprises a water decoction method and a supercritical fluid extraction method, firstly decocting the components of the raw materials by water, preparing the eucommia male flower, the dandelion and the dogwood fruit into a medicine bag when decocting the components by water, putting the medicine bag into a decocting pot, taking out the medicine juice in the decocting pot after the decoction is finished, taking out the medicine bag, naturally cooling the rest astragalus, the bighead atractylodes rhizome, the angelica, the divaricate saposhnikovia root, the weeping forsythia and the sealwort and drying the surface water, and carrying out secondary extraction on the medicine residues by using the supercritical fluid extraction method; when the raw material medicines are decocted by a water decoction method, normal-temperature water is added to soak astragalus membranaceus, bighead atractylodes rhizome, angelica sinensis, wind-proof fructus forsythiae and rhizoma polygonati for 2.5 hours at regular time, then the eucommia staminate flowers, dandelion and the fructus corni placed in the stainless steel filter basket are added to soak the astragalus membranaceus, the bighead atractylodes rhizome, the angelica sinensis, the fructus forsythiae and the rhizoma polygonati for 2.5 hours together, then the decoction is started for 2.5 hours at regular time and in a quantitative mode, the decoction is carried out alternately by mild fire and strong fire until the decoction turns color, the decoction is taken by turning off the fire, the decoction is repeated, the normal-temperature water is added in the decocting process, the water amount is 3.3 times of the raw material medicines when the raw material medicines are soaked for the first time, the water amount is 1.2 times of the raw material medicines when the raw material medicines are decocted for the second time, the eucommia staminate flowers, the dandelion and the fructus corni are taken out before the decoction for the third time, and the decoction is carried out, and the decoction is drained.

Example 6: the difference is based on example 1;

an oral liquid for improving immunity of a patient is prepared by weighing 45 parts of astragalus, 35 parts of bighead atractylodes rhizome, 20 parts of angelica, 15 parts of divaricate saposhnikovia root, 25 parts of eucommia male flower, 13 parts of rhizoma polygonati, 13 parts of cornus officinalis, 12 parts of dandelion and 12 parts of fructus forsythiae in parts by weight, and extracting medicinal components by adopting the following method;

step three, medicine preparation, namely extracting the components of the raw materials in the step two by two times by adopting a common traditional Chinese medicine extraction method, mixing the liquid medicines obtained by two times of extraction, standing to enable the liquid medicine to naturally settle, wherein the adopted traditional Chinese medicine extraction method comprises a water decoction method and a supercritical fluid extraction method, firstly decocting the components of the raw materials by water, preparing the eucommia male flower, the dandelion and the dogwood fruit into a medicine bag when decocting the components by water, putting the medicine bag into a decocting pot, taking out the medicine juice in the decocting pot after the decoction is finished, taking out the medicine bag, naturally cooling the rest astragalus, the bighead atractylodes rhizome, the angelica, the divaricate saposhnikovia root, the weeping forsythia and the sealwort and drying the surface water, and carrying out secondary extraction on the medicine residues by using the supercritical fluid extraction method; when the raw material medicines are decocted by a water decoction method, normal-temperature water is added to soak astragalus membranaceus, bighead atractylodes rhizome, angelica sinensis, wind-proof fructus forsythiae and rhizoma polygonati for 2.5 hours at regular time, then the eucommia staminate flowers, dandelion and the fructus corni placed in the stainless steel filter basket are added to soak the astragalus membranaceus, the bighead atractylodes rhizome, the angelica sinensis, the fructus forsythiae and the rhizoma polygonati for 2.5 hours together, then the decoction is started for 2.5 hours at regular time and in a quantitative mode, the decoction is carried out alternately by mild fire and strong fire until the decoction turns color, the decoction is taken by turning off the fire, the decoction is repeated, the normal-temperature water is added in the decocting process, the water amount is 3.5 times of the raw material medicines when the raw material medicines are soaked for the first time, the water amount is 1.3 times of the raw material medicines when the raw material medicines are decocted for the second time, the eucommia staminate flowers, the dandelion and the fructus corni are taken out before the decoction for the third time, and the decoction is carried out, and the decoction is drained.

Referring to fig. 1-6, the present invention further provides a winnowing device for use in the oral liquid production process of the above embodiments 1-6, comprising a tank 2 and a frame 9, wherein an opening is formed at one end of the tank 2, a sealing plate 3 is fixedly connected to the opening through a locking fastener, an air inlet pipe 4 is fixedly connected to the center of the sealing plate 3 through a circular hole, a grid plate 5 is fixedly connected to the air inlet pipe 4, a ring block 1 is sleeved on the side wall of the tank 2, an annular mounting groove is formed in the inner side of the ring block 1, a transmission mechanism is connected to the mounting groove, two support rods 7 are fixedly connected to the upper end of the frame 9, the side wall of one support rod 7 is rotatably connected to a transverse pipe through a first rolling bearing, one end of the transverse pipe is fixedly connected to one side of the ring block 1, and the other end of the transverse pipe passes through a first rolling bearing and is fixedly connected to a rotary joint, the side wall of the other supporting rod 7 is rotatably connected with a rotating shaft 18 through a third rolling bearing, one end of the rotating shaft 18 is rotatably connected with the side wall of the annular block 1 through a first ball bearing, the side wall of the tank body 2 is provided with a plurality of exhaust holes which are uniformly distributed in a penetrating way, the side wall of the tank body 2 is sleeved with two rubber rings 24, the two rubber rings 24 are both fixedly connected with the inner side of the annular block 1, the center of the lower end of the tank body 2 is rotatably connected with a positioning rod 13 through a second ball bearing, the rod wall of the positioning rod 13 is symmetrically and fixedly connected with a plurality of baffle rods 12 which are uniformly distributed, the lower end of the positioning rod 13 is fixedly connected with a U-shaped frame 10, the upper ends of two vertical parts of the U-shaped frame 10 are both fixedly connected with the lower end of the annular block 1, the inner side of the tank body 2 is fixedly connected with a plurality of flow disturbance plates 11, and a separation net 17 is fixedly connected between the two adjacent flow disturbance plates 11, and one side of the separation net 17 is fixedly connected with the inner wall of the tank body 2, the upper end and the lower end of the annular block 1 are fixedly connected with a plurality of supporting wheels 6, and the supporting wheels 6 are all contacted with the side wall of the tank body 2.

The transmission mechanism comprises a circular ring 14, the inner side of the circular ring 14 is fixedly connected with the side wall of the tank body 2, two corners of the outer side of the circular ring 14 are respectively provided with a conical tooth surface, the circular ring 14 is engaged with a plurality of uniformly distributed first bevel gears 15 through the two conical tooth surfaces, one side of each first bevel gear 15 is fixedly connected with a rotating shaft, one end of each rotating shaft is rotatably connected with the side wall of the mounting groove through a fourth rolling bearing, the upper end of the circular block 1 is fixedly connected with a speed reducing motor 16, the output end of the speed reducing motor 16 penetrates through the side wall of the circular block 1 and is fixedly connected with a second bevel gear 23, the second bevel gear 23 is engaged with the first bevel gear 15, the upper end of the supporting rod 7 is fixedly connected with a connecting piece 20, the connecting piece 20 is rotatably connected with a shaft pin 19 through a connecting hole, one side of the shaft pin is fixedly connected with a positioning block 8, one end of the rotating shaft 18 penetrates through the third rolling bearing and is provided with a right-angle notch, the locating block 8 is clamped with the right-angle notch, one end of the shaft pin 19 is fixedly connected with the elastic sheet 21, one side of the connecting piece 20 is fixedly connected with the clamping block 22, a shaft wall of the rotating shaft 18 is fixedly connected with a gear ring 26, one side of the gear ring 26 is meshed with the gear 25, and one end of the rotating shaft penetrates through the fourth rolling bearing and is fixedly connected with one side of the gear 25.

When the winnowing device is used, a raw material medicine is placed in a tank body 2, a lock catch is used for covering a sealing plate 3, a speed reduction motor 16 is started to drive a second bevel gear 23 to rotate, the second bevel gear 23 drives a first bevel gear 15 to rotate when rotating, the first bevel gear 15 rotates and is matched with a bevel gear surface to drive a ring 14 to rotate, the ring 14 rotates to drive the tank body 2 to rotate along the axial direction of the tank body, a positioning rod 13 and a stop rod 12 are fixed, so that the tank body 2 drives the raw material medicine inside the tank body to be stirred when rotating, an air suction device (not shown in the figure) is used for connecting a quick connector, outside air enters the tank body 2 through an air inlet pipe 4, air in the tank body 2 passes through a separation net 17 and an air outlet hole to enter a transverse pipe and then is pumped out by an outside air suction device, further, dust and chips can be discharged when the raw material medicine is stirred, meanwhile, the first bevel gear 15 drives a transmission shaft to rotate the gear 25, the gear 25 drives the gear ring 26 to rotate the rotating shaft 18 when rotating, at the moment, the rotating shaft 18 plays a role of supporting the annular block, when the positioning block 8 is clamped with a right-angle notch on the rotating shaft 18, the rotating shaft 18 cannot rotate, at the moment, the gear 25 rolls on the surface of the gear ring 26 under the action of the transmission force of the transmission shaft, and the speed reduction motor 16 is controlled by a forward and reverse controller (not shown in the figure) to do forward and reverse rotation motion, so that the speed reduction motor 16 can drive the transmission mechanism to enable the tank body 2 to swing back and forth along the axis of the transverse pipe and the axis of the rotating shaft 18, and also do reciprocating autorotation along the central line of the annular block 1, and can enable the raw medicines in the tank body 2 to mutually collide under the action of the spoiler 17, the positioning rod 13 and the baffle rod 12, thereby efficiently removing dust and debris on the surface of the raw medicines, and reducing the difficulty in refining the extracting solution of the raw medicines in the later stage.

In a test example, the quality test of the oral liquid for improving the immunity of patients is carried out;

1. test materials: oral liquids for enhancing immunity in patients prepared in example 1, example 2, example 3, example 4, example 5 and example 6;

2. the test method comprises the following steps: the oral liquid for improving the immunity of patients prepared in example 1, example 2, example 3, example 4, example 5 and example 6 is subjected to clarity and content determination of astragaloside and astragalus polysaccharide.

3. An experiment step, wherein the clarity measurement is carried out by adopting a turbidity meter allowed to be used;

4. the method for measuring the content of astragaloside IV and astragalus polysaccharide comprises the following steps;

1) preparing a reference solution, accurately weighing 70mg of anhydrous glucose dried to constant weight at 105 ℃, placing in a 100mL volumetric flask, adding water to dissolve and dilute to scale, shaking up, accurately weighing 10mL of glucose aqueous solution, placing in a 100mL volumetric flask, adding water to scale, and shaking up to obtain the glucose aqueous solution.

2) Preparation of sample solution from example 1, example 2, example 3, example 4, example 5 and example 6, 1.0g of sample was accurately weighed, placed in a 250mL volumetric flask, dissolved in 20mL of water, then added with 5mL of 30% zinc sulfate, heated in a water bath for 5min, immediately added with 5mL of potassium ferrocyanide sample under shaking, added with water to the scale after cooling, shaken up, filtered, discarded the initial filtrate, taken with 5mL of continuous filtrate, placed in a 200mL volumetric flask, added with water to the scale, shaken up, and the product was obtained.

3) Measuring step accurately measuring 2mL of each of the reference solution and the sample solution, respectively placing in 10mL volumetric flasks, adding 0.5mL of 2% phenol solution and 5mL of concentrated sulfuric acid, shaking, heating in water bath for 30min, cooling in ice water bath for 15min, shaking, measuring absorbance of the reference solution and the sample solution at 490nm wavelength by ultraviolet spectrophotometry,

5. the results of the experiments are shown in table 1,

oral liquids were produced from the above examples 1-6 and the process;

[ EDIBLE METHOD ] three times a day, one bottle for adults (halved children)

[ caution item ] the product belongs to a pure Chinese medicinal preparation, and has no toxic or side effect and other adverse reactions in 2000 cases of clinical observation.

The product is developed by adopting high-quality excellent traditional Chinese medicines for nourishing heart, liver, spleen, lung, kidney, five internal organs and qi and blood according to the theory of integrating Chinese medicine into one body, preventing diseases and seeking basis for diseases, has the functions of nourishing vital qi of a human body, improving the disease resistance and immunity for resisting external invasion, and achieves the effects of preventing cold and conditioning body rehabilitation after various tumors.

The product comprises the following components in percentage by weight: the traditional Chinese medicine comprises astragalus, angelica, bighead atractylodes rhizome, divaricate saposhnikovia root, rhizoma polygonati, dogwood fruit, dandelion, fructus forsythiae and male eucommia flowers, wherein the astragalus has the effects of tonifying qi, strengthening spleen and strengthening body resistance, the angelica has the effects of replenishing blood and activating blood, the dogwood fruit has the effects of nourishing liver and kidney, the bighead atractylodes rhizome has the effects of tonifying spleen and stomach, the divaricate saposhnikovia root has the effects of dispelling wind and consolidating the constitution, the dandelion and the fructus forsythiae have the effects of clearing away heat and toxic materials and resisting viruses, and the male flowers of the eucommia have the effects of improving immunity, tranquilizing and promoting sleep, resisting aging, resisting oxidation and inhibiting bacteria.

The medicine composition has the functions of nourishing qi and blood of liver and kidney, invigorating spleen, benefiting lung and resisting virus, so as to achieve the effects of improving immunity, preventing cold and conditioning various tumors after operation.

[ PRODUCT INDICATIONS ] can treat hypoimmunity, asthenia, common cold, sweating, watery nasal discharge, listlessness, various postoperative tumors, and deficiency of qi, blood, liver and kidney,

treatment case one, Chen Zhixing, Man, age 75, address Guiyang City

In the first diagnosis, 8 and 25 months in 2020, sweating is caused, wind is feared, mental fatigue and hypodynamia are caused, wind evil attacks and turns when getting up and wearing clothes every morning, namely, the nasal discharge is not clear, the tongue is pale, the fur is thin, white and weak, and the sweating is caused by mobilization, the pulse is thin and weak, and the diagnosis: for cold due to qi deficiency, 30 oral liquids with body constitution strengthening, cold preventing and antitoxic effects are administered, three times a day, one for each time.

The compound treatment is carried out for 9 months and 5 days in 2020, the effect is excellent after the medicine is taken, the symptoms of sweating and snivel clearing disappear, the wind and wind are not afraid, even the wind and cold are accidentally induced, the symptoms of cold do not exist, the diet is recovered to be normal, and 30 patients take the medicine again for strengthening the curative effect.

Second treatment case, Xie somebody, woman, 62 years old, Guiyang City

The initial diagnosis is carried out 6 months and 16 days in 2020, the body is soft and weak, the head is faint and sweaty, the sweating is like rain during movement, the body is afraid of wind, the patient is weak and susceptible to cold, the household central gate seam and the window seam are plugged with things to avoid wind blowing, and the diagnosis is repeated for ten years, wherein the diagnosis comprises that the tongue is pale and the tongue fur is white, the pulse is deep and weak, the cold is caused by qi deficiency, the spontaneous perspiration is caused by qi deficiency, the treatment principle is to tonify qi and strengthen the exterior, and 60 oral liquid for strengthening the body, preventing the cold and resisting the toxin is given three times a day, one oral liquid for each time.

The follow-up diagnosis is carried out in 7 months and 6 days in 2020: after patients self-describe the medicine taking, the effect is good, symptoms such as sweating and wind intolerance are obviously relieved, the sweating is basically avoided, the symptoms of body softness and dizziness are improved, the symptoms of slight cold catching exist at present, and the patients take 60 more medicines for consolidation curative effect.

It is to be noted that the term "comprises," "comprising," or any other variation thereof is intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising an … …" does not exclude the presence of other identical elements in a process, method, article, or apparatus that comprises the element.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims

1. An oral liquid for improving the immunity of a patient is characterized in that: the oral liquid is prepared from the following raw material medicines in parts by weight:

40-45 parts of astragalus membranaceus, 30-35 parts of bighead atractylodes rhizome, 15-20 parts of angelica sinensis, 10-15 parts of divaricate saposhnikovia root, 20-25 parts of eucommia male flowers, 8-13 parts of rhizoma polygonati, 8-13 parts of cornus officinalis, 7-12 parts of dandelion and 7-12 parts of fructus forsythiae.

2. The oral liquid for improving immunity of patients according to claim 1, wherein: the oral liquid is prepared from the following raw material medicines in parts by weight:

3. A process for the preparation of an oral liquid according to claim 1 or 2, characterized in that: comprises the following steps;

4. The process for producing an oral liquid according to claim 3, wherein: the traditional Chinese medicine extraction method adopted in the third step is a water decoction method and a supercritical fluid extraction method, the medicinal ingredients in the raw material medicines are firstly decocted by water, during the water decoction, the eucommia male flower, the dandelion and the dogwood fruit are prepared into a medicine bag and put into a decocting pot, after the decoction, the medicine juice in the decocting pot is taken out, the medicine bag is taken out, the rest astragalus, the bighead atractylodes rhizome, the angelica, the divaricate saposhnikovia root, the weeping forsythia and the sealwort are naturally cooled and dried, and the surface moisture is dried, and the supercritical fluid extraction method is used for carrying out secondary extraction on the medicine residues.

5. The process for producing an oral liquid according to claim 4, wherein: when the raw material medicines are decocted by a water decoction method, normal-temperature water is added to soak astragalus membranaceus, bighead atractylodes rhizome, angelica sinensis, radix sileris, fructus forsythiae and rhizoma polygonati regularly, then the eucommia ulmoides male flowers, the dandelion and the dogwood pulp placed in the stainless steel filter basket are added to soak together, then regular and quantitative decoction is started, the decoction is alternately decocted by mild and strong fire until the decoction changes color, the fire is turned off to take the decoction, and the decoction is repeatedly decocted.

6. The process for producing an oral liquid according to claim 5, wherein: adding normal temperature water in the boiling process, wherein the water amount is 2.5-3.5 times of that of the raw material medicine when the raw material medicine is soaked for the first time, the water amount is 1-1.3 times of that of the raw material medicine when the raw material medicine is decocted for the second time and the third time, taking out eucommia male flowers, dandelion and dogwood fruit before the three times of boiling, and draining the medicine juice when the eucommia male flowers, the dandelion and the dogwood fruit pulp are taken out.

7. An air separation device used in the production process of oral liquid in the production process of claim 3, which is characterized in that: the winnowing device adopted in the second step comprises a tank body (2) and a frame (9), wherein one end of the tank body (2) is provided with an opening, the opening is fixedly connected with a sealing plate (3) through a lock catch, the center of the sealing plate (3) is fixedly connected with an air inlet pipe (4) through a round hole, a grid plate (5) is fixedly connected in the air inlet pipe (4), the side wall of the tank body (2) is sleeved with a ring-shaped block (1), the inner side of the ring-shaped block (1) is provided with an installation groove of an annular structure, a transmission mechanism is connected in the installation groove, the upper end of the frame (9) is fixedly connected with two support rods (7), the side wall of one support rod (7) is rotatably connected with a transverse pipe through a first rolling bearing, one end of the transverse pipe is fixedly connected with one side of the ring-shaped block (1), and the other end of the transverse pipe penetrates through the first rolling bearing and is fixedly connected with a rotary joint, another the lateral wall of bracing piece (7) rotates through third antifriction bearing and is connected with pivot (18), the one end of pivot (18) is rotated through the lateral wall of first ball bearing and annular piece (1) and is connected, the lateral wall of the jar body (2) runs through the exhaust hole of having seted up a plurality of evenly distributed, the lateral wall of the jar body (2) has cup jointed two rubber rings (24), two rubber ring (24) all with the inboard fixed connection of annular piece (1).

8. The air separation device used in the production process of the oral liquid according to claim 7, wherein: the transmission mechanism comprises a circular ring (14), the inner side of the circular ring (14) is fixedly connected with the side wall of the tank body (2), two corner positions of the outer side of the circular ring (14) are respectively provided with a conical tooth surface, the circular ring (14) is meshed with a plurality of uniformly distributed first bevel gears (15) through the two conical tooth surfaces, one side of each first bevel gear (15) is fixedly connected with a rotating shaft, one end of each rotating shaft is rotatably connected with the side wall of the corresponding mounting groove through a fourth rolling bearing, the upper end of each annular block (1) is fixedly connected with a speed reducing motor (16), the output end of each speed reducing motor (16) penetrates through the side wall of the corresponding annular block (1) and is fixedly connected with a second bevel gear (23), and the second bevel gear (23) is meshed with the first bevel gears (15).

9. The air separation device used in the production process of the oral liquid according to claim 8, wherein: the upper end fixedly connected with connecting piece (20) of bracing piece (7), connecting piece (20) rotate through the connecting hole and are connected with pivot (19), one side fixedly connected with locating piece (8) of pivot, third antifriction bearing is passed and right angle breach has been seted up to the one end of pivot (18), locating piece (8) and right angle breach joint, the one end fixedly connected with flexure strip (21) of pivot (19), one side fixedly connected with fixture block (22) of connecting piece (20), fixedly connected with ring gear (26) on the axle wall of pivot (18), one side meshing of ring gear (26) has gear (25), the one end of rotation axis pass fourth antifriction bearing and with one side fixed connection of gear (25).

10. The air separation device used in the production process of the oral liquid according to claim 7, wherein: the utility model discloses a jar body, including jar body (2), locating lever (13) is connected with through the rotation of second ball bearing in the lower extreme center department of jar body (2), symmetry fixedly connected with a plurality of evenly distributed's pin (12) on the pole wall of locating lever (13), the lower extreme fixedly connected with U type frame (10) of locating lever (13), two vertical portion upper ends of U type frame (10) all with the lower extreme fixed connection of ring block (1), a plurality of spoilers (11) of inboard fixedly connected with of the jar body (2), wherein adjacent two equal fixedly connected with separates net (17) between spoiler (11), and separate one side of net (17) and the inner wall fixed connection of the jar body (2), the equal fixedly connected with of the upper and lower both ends of ring block (1) a plurality of supporting wheels (6), it is a plurality of supporting wheels (6) all contact with the lateral wall of the jar body (2).