CN113577111A - Liquid drop for preventing virus infection of mammals and treating intestinal diarrhea - Google Patents
Liquid drop for preventing virus infection of mammals and treating intestinal diarrhea Download PDFInfo
- Publication number
- CN113577111A CN113577111A CN202110982332.4A CN202110982332A CN113577111A CN 113577111 A CN113577111 A CN 113577111A CN 202110982332 A CN202110982332 A CN 202110982332A CN 113577111 A CN113577111 A CN 113577111A
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- diarrhea
- mammals
- virus infection
- liquid drop
- intestinal
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- 206010012735 Diarrhoea Diseases 0.000 title claims abstract description 34
- 230000000968 intestinal effect Effects 0.000 title claims abstract description 21
- 241000124008 Mammalia Species 0.000 title claims abstract description 17
- 230000009385 viral infection Effects 0.000 title claims abstract description 17
- 239000007788 liquid Substances 0.000 title claims abstract description 14
- 239000002994 raw material Substances 0.000 claims abstract description 13
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims abstract description 11
- 241000901050 Bifidobacterium animalis subsp. lactis Species 0.000 claims abstract description 7
- 229940009289 bifidobacterium lactis Drugs 0.000 claims abstract description 7
- 241000186000 Bifidobacterium Species 0.000 description 13
- 235000013336 milk Nutrition 0.000 description 8
- 239000008267 milk Substances 0.000 description 8
- 210000004080 milk Anatomy 0.000 description 8
- 238000002360 preparation method Methods 0.000 description 5
- 206010012742 Diarrhoea infectious Diseases 0.000 description 4
- 208000019902 chronic diarrheal disease Diseases 0.000 description 4
- 208000001848 dysentery Diseases 0.000 description 4
- 230000008774 maternal effect Effects 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 244000052769 pathogen Species 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 230000003115 biocidal effect Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 206010010774 Constipation Diseases 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- 201000010538 Lactose Intolerance Diseases 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 210000003022 colostrum Anatomy 0.000 description 2
- 235000021277 colostrum Nutrition 0.000 description 2
- 230000013872 defecation Effects 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 206010000060 Abdominal distension Diseases 0.000 description 1
- 206010068286 Anorectal discomfort Diseases 0.000 description 1
- 102100026189 Beta-galactosidase Human genes 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 241000282465 Canis Species 0.000 description 1
- 208000003322 Coinfection Diseases 0.000 description 1
- 206010012110 Defaecation urgency Diseases 0.000 description 1
- 241000282324 Felis Species 0.000 description 1
- 208000005577 Gastroenteritis Diseases 0.000 description 1
- 208000018522 Gastrointestinal disease Diseases 0.000 description 1
- 206010017999 Gastrointestinal pain Diseases 0.000 description 1
- 206010021639 Incontinence Diseases 0.000 description 1
- 108010059881 Lactase Proteins 0.000 description 1
- 241000186660 Lactobacillus Species 0.000 description 1
- 235000013960 Lactobacillus bulgaricus Nutrition 0.000 description 1
- 241000186672 Lactobacillus delbrueckii subsp. bulgaricus Species 0.000 description 1
- 208000003100 Pseudomembranous Enterocolitis Diseases 0.000 description 1
- 241000194020 Streptococcus thermophilus Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 208000023505 abnormal feces Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 201000009840 acute diarrhea Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 108010005774 beta-Galactosidase Proteins 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 208000024330 bloating Diseases 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 208000028774 intestinal disease Diseases 0.000 description 1
- 229940116108 lactase Drugs 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 229940039696 lactobacillus Drugs 0.000 description 1
- 229940004208 lactobacillus bulgaricus Drugs 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229940057917 medium chain triglycerides Drugs 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 230000008855 peristalsis Effects 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 239000006041 probiotic Substances 0.000 description 1
- 235000018291 probiotics Nutrition 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 235000021391 short chain fatty acids Nutrition 0.000 description 1
- 150000004666 short chain fatty acids Chemical class 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 235000013618 yogurt Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/745—Bifidobacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/225—Polycarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Emergency Medicine (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nutrition Science (AREA)
- Engineering & Computer Science (AREA)
- Physiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Dispersion Chemistry (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a liquid drop for preventing virus infection of mammals and treating intestinal diarrhea, which is prepared from the following raw materials in volume ratio: 1-5% of bifidobacterium lactis and 95-99% of medium-chain triglyceride. The invention can effectively prevent virus infection of mammals and treat intestinal diarrhea.
Description
Technical Field
The invention relates to the technical field of probiotics, in particular to a liquid drop for preventing virus infection of mammals and treating intestinal diarrhea.
Background
In mammalian species, immunity to pathogens is transferred from the mother to the offspring by maternal antibodies provided by the placenta or colostrum. The mother can only transfer those antibodies that are produced by the body due to natural exposure or vaccination. However, maternal antibody transfer levels are affected by recent exposure to specific pathogens. If the maternal colostrum contains insufficient amounts of antibodies against certain pathogens, the neonate will have insufficient immunity against these diseases.
Members of the canine and feline families share many features in common with humans and bovines. In particular, they utilize maternal passive immunization to protect newborns, are susceptible to infectious diarrhea and other intestinal diseases and lack an effective treatment for common diarrhea infections.
Diarrhea is commonly called as diarrhea, and means that the frequency of defecation obviously exceeds the frequency of daily habit, the feces is thin, the moisture is increased, the daily defecation amount exceeds 200g, or the diarrhea contains undigested food, purulent blood and mucus. Diarrhea is clinically accompanied by symptoms such as defecation urgency, anal discomfort, incontinence and the like. Usually, infection with pathogens such as bacteria, viruses or parasites is the leading cause of diarrhea, also known as infectious diarrhea or gastroenteritis, and the occurrence and spread of infectious diarrhea is considered to be a result of poor hygiene.
Currently, the most common method for treating the travel diarrhea, namely the bacterial infectious diarrhea, is antibiotic treatment, but the use of the antibiotic can greatly destroy the balance of normal flora in intestinal tracts of patients, and fatal secondary infection is easy to occur.
Disclosure of Invention
The invention aims to provide a liquid drop for preventing the virus infection of mammals and treating the intestinal diarrhea, which can effectively prevent the virus infection of the mammals and treat the intestinal diarrhea.
In order to solve the technical problems, the invention adopts the following technical scheme:
the invention provides a liquid drop for preventing virus infection of mammals and treating intestinal diarrhea, which is characterized by being prepared from the following raw materials in volume ratio: 1-5% of bifidobacterium lactis and 95-99% of medium-chain triglyceride.
The invention also relates to a preparation method of the liquid drop for preventing the virus infection of the mammals and treating the intestinal diarrhea, which comprises the following steps:
step 1: preparing milk bifidobacterium and medium-chain triglyceride as raw materials in proportion;
step 2: mixing the two materials, stirring at 45 deg.C below 45 deg.C, suspending completely, and bottling.
The using method comprises the following steps: one to two drops per administration, corresponding to 0.5 ml.
The invention has the beneficial effects that: can effectively prevent virus infection of mammals and treat intestinal diarrhea.
The following further explains the beneficial effects of the present invention in combination with the efficacy of the main ingredients in the present invention:
bifidobacterium lactis: 1. treatment of chronic diarrhea and antibiotic-associated diarrhea: the Bifidobacterium has the effect of regulating intestinal flora. Clinical observation and research on chronic diarrhea patients by using bifidobacterium show that after the bifidobacterium is taken for two weeks, the patients have abnormal stool frequency and shape and disappear clinical symptoms, the total effective rate is 90.3 percent, and the relapse rate is low. Bifidobacteria formulations have been used by many domestic hospitals as the first choice for the treatment of chronic diarrhea. In addition, bifidobacteria can also treat antibiotic-associated diarrheal diseases caused by overuse of antibiotics. 380 cases of pseudomembranous enteritis are treated by adopting the bifidobacterium preparation, the clinical total cure rate has no obvious difference, but the clinical side effect and the recurrence rate are both obviously reduced. The bifidobacterium has good treatment effect on acute and chronic diarrhea of children; 2. effectively relieving constipation: the bifidobacterium can inhibit the growth of intestinal putrefying bacteria and the formation of toxic metabolites by adjusting intestinal flora and generating short-chain fatty acids such as acetic acid, lactic acid and the like, and stimulate the intestinal peristalsis, thereby reducing excessive water absorption and relieving constipation symptoms; 3. promoting the digestion of lactose by human body: milk contains rich nutrients. Lactose in milk is not broken down by lactase deficient persons who often develop gastrointestinal disturbances after drinking milk, resulting in gastrointestinal cramps, bloating or diarrhea, i.e. lactose intolerance. The fermented yogurt is prepared by fermenting milk with lactobacillus such as lactobacillus bulgaricus, streptococcus thermophilus and bifidobacterium, and can effectively relieve lactose intolerance.
Medium chain triglycerides: the medium chain triglyceride has functions of supplying body and storing energy, and has functions of fixing and protecting viscera.
Detailed Description
The technical solutions of the present invention will be described clearly and completely in the following embodiments of the present invention, and it should be understood that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
A liquid drop for preventing virus infection of mammals and treating intestinal diarrhea is prepared from the following raw materials: 2% of bifidobacterium lactis and 98% of medium-chain triglyceride.
The preparation method of the liquid drop for preventing the virus infection of the mammals and treating the intestinal diarrhea comprises the following specific steps:
step 1: preparing milk bifidobacterium and medium-chain triglyceride as raw materials in proportion;
step 2: mixing the two raw materials, stirring for 45 min at 30 deg.C, suspending completely and uniformly, and bottling.
Example 2
A liquid drop for preventing virus infection of mammals and treating intestinal diarrhea is prepared from the following raw materials: bifidobacterium lactis 1% and medium chain triglyceride 99%.
The preparation method of the liquid drop for preventing the virus infection of the mammals and treating the intestinal diarrhea comprises the following specific steps:
step 1: preparing milk bifidobacterium and medium-chain triglyceride as raw materials in proportion;
step 2: mixing the two raw materials, stirring for 45 min at 40 deg.C, suspending completely and packaging.
Example 3
A liquid drop for preventing virus infection of mammals and treating intestinal diarrhea is prepared from the following raw materials: 4% of bifidobacterium lactis and 96% of medium-chain triglyceride.
The preparation method of the liquid drop for preventing the virus infection of the mammals and treating the intestinal diarrhea comprises the following specific steps:
step 1: preparing milk bifidobacterium and medium-chain triglyceride as raw materials in proportion;
step 2: mixing the two raw materials, stirring for 45 min at 32 deg.C, suspending completely and packaging.
Clinical trials applying the present invention:
the trial participants were 120 cases, wherein 60 cases of men and 60 cases of women were aged 10-55 years, and 120 cases were diarrhea patients, and 120 cases were divided into 3 groups, and the 3 groups were similar as much as possible, so that the patients were comparable.
The treatment method comprises the following steps: the administration is once a day and half a month later.
Diagnostic criteria
The method has the following advantages: the diarrhea condition is improved.
As a result: in example 1, 120 testers are effective, and the effective rate is 91.7%.
In example 2, 120 testers are effective, and the effective rate is 95.8%.
In example 3, 120 testers, 112 effective, and 93.3% effective rate.
It will be apparent to those skilled in the art that various changes and modifications may be made in the present invention without departing from the spirit and scope of the invention. Thus, if such modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include such modifications and variations.
Claims (1)
1. A liquid drop for preventing virus infection of mammals and treating intestinal diarrhea is characterized by being prepared from the following raw materials in volume ratio: 1-5% of bifidobacterium lactis and 95-99% of medium-chain triglyceride.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110982332.4A CN113577111A (en) | 2021-08-25 | 2021-08-25 | Liquid drop for preventing virus infection of mammals and treating intestinal diarrhea |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110982332.4A CN113577111A (en) | 2021-08-25 | 2021-08-25 | Liquid drop for preventing virus infection of mammals and treating intestinal diarrhea |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113577111A true CN113577111A (en) | 2021-11-02 |
Family
ID=78239562
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110982332.4A Pending CN113577111A (en) | 2021-08-25 | 2021-08-25 | Liquid drop for preventing virus infection of mammals and treating intestinal diarrhea |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113577111A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110583937A (en) * | 2019-10-19 | 2019-12-20 | 上海英库商务咨询有限公司 | Bifidobacterium lactis beverage and preparation method thereof |
| CN110623271A (en) * | 2019-10-19 | 2019-12-31 | 上海英库商务咨询有限公司 | Bifidobacterium animalis beverage and its preparing process |
| CN111588738A (en) * | 2020-06-03 | 2020-08-28 | 金华银河生物科技有限公司 | Probiotic composition capable of relieving or treating travel diarrhea and application thereof |
-
2021
- 2021-08-25 CN CN202110982332.4A patent/CN113577111A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110583937A (en) * | 2019-10-19 | 2019-12-20 | 上海英库商务咨询有限公司 | Bifidobacterium lactis beverage and preparation method thereof |
| CN110623271A (en) * | 2019-10-19 | 2019-12-31 | 上海英库商务咨询有限公司 | Bifidobacterium animalis beverage and its preparing process |
| CN111588738A (en) * | 2020-06-03 | 2020-08-28 | 金华银河生物科技有限公司 | Probiotic composition capable of relieving or treating travel diarrhea and application thereof |
Non-Patent Citations (1)
| Title |
|---|
| 席德清: "乳脂及乳脂产品科学与技术", 中国物资出版社, pages: 160 * |
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Application publication date: 20211102 |
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