CN113576550B - Conjunctival cell brush convenient to adjust and used for eye conjunctival cell sampling - Google Patents
Conjunctival cell brush convenient to adjust and used for eye conjunctival cell sampling Download PDFInfo
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- CN113576550B CN113576550B CN202110801183.7A CN202110801183A CN113576550B CN 113576550 B CN113576550 B CN 113576550B CN 202110801183 A CN202110801183 A CN 202110801183A CN 113576550 B CN113576550 B CN 113576550B
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/02—Instruments for taking cell samples or for biopsy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/02—Instruments for taking cell samples or for biopsy
- A61B2010/0216—Sampling brushes
Abstract
The invention discloses a conjunctival cell brush which is used for eye conjunctival cell sampling and is convenient to adjust, and the conjunctival cell brush comprises a roller and a connecting shaft, wherein two end faces of the roller are regular triangles, each side face of the roller is rectangular, each side face of the roller is provided with a group of movable brush plates, the size of each brush plate is the same as that of the side face of the roller, the front end of the connecting shaft penetrates through the center of one end face of the roller and is rotationally connected with the roller, the inside of the roller is hollow, a limiting part used for limiting the transverse sliding between the connecting shaft and the roller is arranged at the position, close to the foremost end, of the connecting shaft, and a movable groove used for being movably matched with the tail end of the connecting shaft is arranged at the position, corresponding to the limiting part, of the inside of the roller. The conjunctival cytobrush provided by the invention realizes the recycling of the conjunctival cytobrush, and the internal structure of the conjunctival cytobrush is reasonably arranged according to the structural characteristics of the eyes of a sampled person, so that the purposes of large sampling quantity, high sampling speed, intact cells, high cell separation speed, convenience in cleaning and greenness and no pollution are achieved.
Description
Technical Field
The invention relates to the technical field of ophthalmic conjunctival medical devices, in particular to a conjunctival cell brush which is used for sampling ocular conjunctival cells and is convenient to adjust.
Background
The conjunctiva is a layer of mucosa covering the upper eyelid, the lower eyelid and the front of the eyeball, is a transparent film formed by a plurality of columnar epithelium and a small amount of connective tissue, is a palpebral conjunctiva lining the inner surface of the eyelid, is a bulbar conjunctiva stuck to the front of the eyeball, and is mutually continuous, and when the eyelid is closed, a gap surrounded by the conjunctiva is called as a conjunctiva sac, so that the palpebral movement is protected and facilitated. The turning part of bulbar conjunctiva and palpebral conjunctiva is called vault conjunctiva, the conjunctiva contains rich blood vessels and nerve endings, and has a small amount of mucous glands, can secrete mucous, lubricate eyeball so as to reduce friction between palpebral conjunctiva and cornea, and trachoma chlamydia mainly invades palpebral conjunctiva and vault conjunctiva. Both acute bacterial conjunctivitis and viral conjunctivitis are caused by infection of the conjunctiva with bacteria and viruses, and are infectious.
The study of conjunctival cytology has great significance for clinical diagnosis of conjunctival diseases, and research on conjunctival cells has been started as early as 40 s Thygeson, norn, etc., and has been done a lot of work. The examination method comprises the steps of firstly wiping the conjunctival surface with a cotton stick or scraping the conjunctival surface with a blunt narrow knife, coating the scraped product on a glass slide, and carrying out qualitative analysis by using Jie or Rui's stain to observe the conjunctival epithelial cell components. In 1950 Norn, quantitative analysis was further performed by using a glass pipette with a rubber ball at one end, the length of the pipette was 10cm and the diameter was 1.5mm, sucking secretion from the outside of the subconjunctival fornix with the pipette, and then applying the pipette onto a glass slide to examine the cell components with a dye microscope.
Conjunctival scraping or smear is made from conjunctival epithelial secretion cells and plays a key role in the diagnosis and treatment of the following conditions, xerosis conjunctiva: the examination of the bulbar conjunctiva with the doctor blade revealed keratinized particles of epithelial cells and a number of xerobacteria; pharyngeal conjunctival heat: a large number of monocytes are scraped by conjunctiva and cultured without bacterial growth; vernal conjunctivitis: the conjunctival wiper contains eosinophils or eosinophilic particles; epidemic keratoconjunctivitis: labeling with fluorescein-labeled antibody, and detecting that virus antigen exists in infected epithelial cells in almost all cases; inclusion body conjunctivitis: inclusion bodies were visible with conjunctival wiper blades.
Sampling of conjunctival cells is an indispensable step for studying conjunctival cells, and the existing conjunctival cell sampling method comprises the following steps: the method comprises the steps of cutting conjunctival epithelial tissue blocks, scraping conjunctival epithelial cells and marking conjunctival imprinted cell samples, wherein the cutting of the conjunctival epithelial tissue blocks needs to be performed on a patient after anesthesia, and is easy to cause infection; conjunctival marking a cell sample is to attach a sterile conjunctival cell test strip to the bulbar conjunctiva under the eyeball of a subject, but the test strip is easy to cause discomfort or anaphylactic reaction after being placed in the eyeball of the subject for a long time. Therefore, the conjunctival cell brush is convenient to use, can be used for getting deeper cells, and has good development prospect.
Sampling of conjunctival cells is an indispensable step for studying conjunctival cells, and the existing conjunctival cell sampling method comprises the following steps: conjunctival epithelial cell scraping sheets and conjunctival imprinted cell samples are more commonly used, wherein the conjunctival epithelial cell scraping sheets are dangerous to operate, have great damage to cells and are easy to cause infection; the conjunctiva marking cell sample is prepared by attaching sterile conjunctival cell test paper to different parts of the bulbar conjunctiva of a subject for multiple times, has complex operation and takes much time, and because the cell and the cell test paper are firmly attached, the cell test paper needs to be oscillated for a long time, has great influence on the cell and is easy to cause the reduction of the cell survival rate. Therefore, the conjunctival cell brush is convenient to use and can brush conjunctival cells quickly, and has good development prospect.
Disclosure of Invention
In view of the above problems, the present invention provides a conjunctival cell brush for ocular conjunctival cell sampling which is convenient to adjust.
The technical scheme of the invention is as follows:
the conjunctival cell brush comprises a roller and a connecting shaft, wherein two end faces of the roller are regular triangles, each side face of the roller is rectangular in size, each side face of the roller is provided with a group of movable brush plates, the size of each brush plate is identical to that of each side face of the roller, and the front end of the connecting shaft penetrates through the center of one end face of the roller and is in rotary connection with the roller, and the inside of the roller is hollow;
a limiting block for preventing the brush plate from separating from the roller is arranged at the center of the bottom of the brush plate and is close to one end of the connecting shaft, the limiting block penetrates through the side surface of the roller and extends into the roller, a magnetic suction plate for fixing the brush plate and the roller with the connecting shaft is arranged at the center of the bottom of the brush plate at one side of the limiting block, a circle of magnetic suction parts for mutually attracting and attaching the brush plate are arranged at the positions corresponding to the connecting shaft and the magnetic suction plate, the end surfaces of the magnetic suction plates are arranged in a circular arc shape, anti-skid parts are arranged at two sides of the end surfaces of the magnetic suction plates, two groups of reset plates are arranged at the center of the inner side surface of the roller at one side of the magnetic suction plate, a first push plate penetrating through the side surface of the roller is arranged at the positions corresponding to the brush plate and the reset plate, a heating plate is arranged at the center of the inner side surface of the roller at the middle of the two groups of the reset plates, an inductor is arranged at one side of the heating plate, and an induction push rod for triggering an inductor switch after the brush plate and the inductor are moved is arranged at the positions corresponding to the inductor;
a limiting part for limiting the transverse sliding between the connecting shaft and the roller is arranged at the position, close to the forefront end, of the connecting shaft, and a movable groove for movably matching with the tail end of the connecting shaft is arranged at the position, corresponding to the limiting part, inside the roller;
the brush hair is arranged on the outer surface of the brush plate.
Further, the tail end of the connecting shaft is provided with a handle, and the handle and the connecting shaft are detachably arranged, so that the roller and the brush plate can be replaced more conveniently.
Further, the spring drives the reset plate to push the first push plate away from the inner side surface of the roller, the limiting block is attached to the inner side surface of the roller, and the brush plate is prevented from being separated from the roller through the limiting plate.
Furthermore, the anti-skid part surface is provided with anti-skid stripes, and the anti-skid stripes are arranged in a plurality of transverse wave lines, so that the anti-skid stripes have larger friction force in the longitudinal direction and smaller friction force in the transverse direction, the brush plate is more firmly fixed when being locked, and meanwhile, the anti-skid brush plate is convenient to unlock.
Further, the springs are two groups and are respectively positioned at two sides of the first push plate, so that the brush plate can be conveniently locked and reset.
Further, the diameter of the connecting shaft where the limiting part is located is smaller than that of other connecting shafts, the limiting part is arranged in an annular groove at the front end of the connecting shaft, a round groove is formed in the roller corresponding to the annular groove, the limiting part comprises a plurality of spring rods which are circumferentially arranged, sleeve rods which are slidably arranged at the outer ends of the spring rods are located, limiting caps which are fixedly arranged at the tail ends of the sleeve rods are sequentially connected into a whole through a group of connecting rods, a second push plate penetrating through the side face of the roller is arranged at the position where the brush plate corresponds to the limiting part, the second push plate extends into the round groove and is used for pushing the limiting caps to enable each group of sleeve rods to synchronously slide inwards along the spring rods, and the roller and the connecting shaft can relatively rotate through the arrangement of the limiting part and can be conveniently unlocked after the roller and the connecting shaft are locked, so that conjunctival cells can be collected smoothly.
Still further, stopper, magnetism are inhaled board, first push pedal, response push rod, second push pedal all with cylinder is sealed and sliding connection, prevents that inside entering debris of cylinder or the damage inner structure of intaking.
Preferably, the upper surface of spacing cap is the arc setting, and the both sides face of spacing cap is the plane setting, makes things convenient for the second push pedal to promote spacing cap, and spacing cap side prevents that the cylinder from sliding.
Further, the brush hair is made of silica gel or cotton, and proper brush hair materials can be selected according to requirements, so that the collection of conjunctival cells is facilitated.
The beneficial effects of the invention are as follows:
(1) The conjunctival cell brush is used for sampling eye conjunctival cells, a disposable sampling brush is not used any more, the repeated utilization of the conjunctival cell brush is realized, the internal structure of the conjunctival cell brush is reasonably arranged according to the structural characteristics of conjunctival cells and eyes of a sampled person, the purposes of a large sampling quantity, high sampling speed, intact cells, high cell separation speed, convenience in cleaning and environmental friendliness are achieved, the sterile operation can be realized, and the clinical use is convenient.
(2) According to the conjunctival cell brush, compared with a simple cylinder design, the triangular rectangular design of the brush plate and the roller greatly increases the contact area of sampling, so that the number of the taken cell samples is more, and each surface is attached with the membranous cells, the phenomenon that the cells are repeatedly scraped from the same surface to cause cell death can not occur, the survival rate of the membranous cells is improved, the roller can be locked and stopped to rotate by pressing the brush plate, the use is convenient and quick, and the work load of medical care research staff is reduced.
(3) According to the conjunctival cell brush, the brush plate can be heated to the body surface temperature through the heating plate arranged in the roller, so that the body feeling of a sampled person is improved, and the uncomfortable feeling of the sampled person is reduced.
(4) According to the conjunctival cell brush, the roller can be well fixed and rotated through the limiting part, and the limiting part can be contracted by matching with the second push plate, so that the roller can be locked and unlocked, and the operation is simple and effective.
(5) The conjunctival cell brush can be cleaned by whole body water or ultrasonic after the brush plate is locked, the brush hair is made of silica gel or cotton according to the requirements, the cleaning and the disinfection are cleaner, the replacement is convenient, and water or sundries are not easy to enter the inside of the roller so as to prevent the damage of the inner structure of the roller.
Drawings
FIG. 1 is a schematic view of the overall structure of a conjunctival cytobrush of the present invention;
FIG. 2 is a schematic view showing the internal structure of the conjunctival cytobrush of the present invention;
FIG. 3 is a schematic view showing the bottom structure of a brush plate of the conjunctival cell brush of the present invention;
FIG. 4 is a cross-sectional view of the roller at the stopper location of the conjunctival cytobrush of the present invention;
FIG. 5 is a cross-sectional view of the drum at the position of the magnetic plate of the conjunctival cell brush of the present invention;
FIG. 6 is a cross-sectional view of the roller at the location of the reset plate of the conjunctival cytobrush of the present invention;
FIG. 7 is a cross-sectional view of the drum at the location of the heating plate of the conjunctival cell brush of the present invention;
FIG. 8 is a schematic view of the structure of the front end limiting part of the connecting shaft of the conjunctival cytobrush of the present invention;
FIG. 9 is a cross-sectional view of the drum at the location of the stopper of the conjunctival cytobrush of the present invention;
fig. 10 is a schematic view of the structure of the anti-slip part of the conjunctival cytobrush of the present invention.
The device comprises a 1-roller, a 11-reset plate, a 12-spring, a 13-heating plate, a 14-sensor, a 15-movable groove, a 16-round groove, a 2-connecting shaft, a 21-magnetic attraction part, a 22-annular groove, a 3-brush plate, a 31-limiting block, a 32-magnetic attraction plate, a 33-anti-slip part, a 34-first push plate, a 35-induction push rod, a 36-second push plate, a 4-limiting part, a 41-spring rod, a 42-loop bar, a 43-limiting cap, a 44-connecting rod and a 5-handle.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and the terms "front and back", "left and right" in the embodiments of the present invention are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implying a location of an indicated technical feature.
Example 1
As shown in fig. 1, a conjunctival cell brush for eye conjunctival cell sampling convenient to adjust, including cylinder 1 and connecting axle 2, the both ends face of cylinder 1 is regular triangle-shaped, and every side of cylinder 1 is the same size and is the rectangle, and every side of cylinder 1 all is equipped with a set of mobilizable brush board 3, and brush board 3 surface is equipped with the brush hair, and the brush hair is the silica gel material, and the size of brush board 3 is the same with the side size of cylinder 1, and the front end of connecting axle 2 runs through the terminal surface center of cylinder 1 and rotates with cylinder 1 to be connected, and cylinder 1 inside cavity sets up, and connecting axle 2 end is equipped with handle 5, and handle 5 and connecting axle 2 can dismantle the setting.
As shown in fig. 2-7 and 10, one end of the brush plate 3 near the connecting shaft 2 is provided with a limiting block 31 for preventing the brush plate 3 from separating from the roller 1, the limiting block 31 penetrates through the side surface of the roller 1 and extends into the roller 1, the center of the bottom of the brush plate 3 at one side of the limiting block 31 is provided with a magnetic suction plate 32 for fixing the brush plate 3 and the roller 1 with the connecting shaft 2, the position of the connecting shaft 2 corresponding to the magnetic suction plate 32 is provided with a circle of magnetic suction part 21 for mutually attracting and attaching with the magnetic suction plate 32, the end surface of the magnetic suction plate 32 is in a circular arc shape, two sides of the end surface of the magnetic suction plate 32 are provided with anti-skid parts 33, the surfaces of the anti-skid parts 33 are provided with anti-skid stripes, the anti-skid stripes are in a plurality of transverse wave lines, the center of the inner side surface of the roller 1 at one side of the magnetic suction plate 32 is provided with two groups of reset plates 11, each group of reset plates 11 are connected with the inner side surface of the roller 1 through springs 12, a first push plate 34 penetrating through the side surface of the roller 1 is arranged at the position corresponding to the brush plate 3 and the reset plates 11, two groups of springs 12 are arranged on two sides of the first push plate 34 respectively, the springs 12 drive the reset plates 11 to push the first push plate 34 away from the inner side surface of the roller 1, a limiting block 31 is attached to the inner side surface of the roller 1, a heating plate 13 is arranged at the center of the inner side surface of the roller 1 in the middle of the two groups of reset plates 11, the heating plate 13 is an inner structure of the roller 1, the shape structure of which is adjusted by the commercially available nano microcrystalline infrared heating plate, an inductor 14 is arranged on one side of the heating plate 13, and an induction push rod 35 for triggering the switch of the inductor 14 after the brush plate 3 and the inductor 14 are arranged at the position corresponding to the inductor 14.
As shown in fig. 2, 3, 8 and 9, a limiting part 4 for limiting the transverse sliding between the connecting shaft 2 and the roller 1 is arranged at the position of the connecting shaft 2 near the forefront end, and a movable groove 15 for movably matching with the tail end of the connecting shaft 2 is arranged at the position of the inner part of the roller 1 corresponding to the limiting part 4; the diameter of the connecting shaft 2 where the limiting part 4 is located is 3/4 of the diameter of the connecting shaft 2 of other parts, the limiting part 4 is arranged in an annular groove 22 at the front end of the connecting shaft 2, a round groove 16 is formed in the roller 1 corresponding to the annular groove 22, the limiting part 4 comprises a plurality of spring rods 41 which are circumferentially arranged, sleeve rods 42 which are arranged at the outer ends of the spring rods 41 in a sliding mode, limiting caps 43 which are fixedly arranged at the tail ends of the sleeve rods 42, the upper surfaces of the limiting caps 43 are arc-shaped, two side surfaces of the limiting caps 43 are plane surfaces, the middle parts of the sleeve rods 42 are sequentially connected into a whole through a group of connecting rods 44, a second push plate 36 penetrating through the side surface of the roller 1 is arranged at the position of the brush plate 3 corresponding to the limiting part 4, and the second push plate 36 extends into the round groove 16 to push the limiting caps 43 so that each group of sleeve rods 42 synchronously slide inwards along the spring rods 41.
As shown in fig. 3, the limiting block 31, the magnetic attraction plate 32, the first push plate 34, the induction push rod 35 and the second push plate 36 are all in sealing and sliding connection with the roller 1.
The method for sampling conjunctival cells of a sampled person by using the conjunctival cell brush comprises the following steps and working principles:
when the disposable gloves are used, firstly, a medical staff wears disposable gloves, holds the handle 5, rotates the roller 1 until the brush plate 3 rotates to a proper position, namely, the brush plate 3 which is required to scrape conjunctival cells is positioned right below, then presses the brush plate 3, so that the brush plate 3 is tightly attached to the roller 1, the roller 1 is locked and can not rotate around the connecting shaft 2 any more, and then the medical staff inverts the upper eyelid of a sampled person to scrape conjunctival cells for sampling.
The working principle of the brush plate 3 is as follows:
when the brush plate 3 is pressed, the limiting block 31 moves to the inner space of the roller 1, and the limiting is released; the magnetic plate 32 moves to the inner space of the roller 1 until being butted with the magnetic part 21 on the connecting shaft 2 and attracted and attached, and the magnetic plate 32 is prevented from moving back and forth under the action of the anti-skid part 33, namely the roller 1 stops rotating; the first push plate 34 moves towards the inner space of the roller 1 and pushes the reset plate 11 to move, and the reset plate 11 moves towards the inner part of the roller 1 for a certain distance under the action of a spring; the induction push rod 35 moves to the inner space of the roller 1 until the induction push rod 35 contacts with the inductor 14, and the switch of the heating plate 13 is triggered, so that the heating plate 13 starts to work to heat the brush plate 3 and the brush hair;
the working principle of the limiting part 4:
meanwhile, when the brush plate 3 is pressed, the second push plate 36 moves into the circular groove 16 in the roller 1 until the second push plate 36 contacts with the 2-3 groups of limit caps 43 corresponding to the second push plate 36, and pushes the 2-3 groups of limit caps 43 into the annular groove 22, and as each group of loop bars 42 are connected through the connecting rod 44, all the loop bars 42 drive the limit caps 43 to move along the spring bars 41 into the annular groove 22, so that the side surfaces of the limit caps 43 are not contacted with the side walls of the circular groove 16 any more, and are in contact with the lateral limit;
when sampling of conjunctival cells of a lower eyelid is completed, the conjunctival cells of the lower eyelid need to be sampled, the lower eyelid needs to be locked by the roller 1, the front end of the roller 1 is only pressed to lightly push the front end of the roller 1 to one side of the connecting shaft 2, the front end of the connecting shaft 2 is deep into the movable groove 15 under the action of the anti-skid part 33, the magnetic suction plate 32 is not in contact with the magnetic suction part 21, at the moment, the reset plate 11 is reset under the action of the spring 12 to push the first push plate 34 away from the inner side of the roller 1, the limiting block 31 is clamped with the inner side of the roller 1, the sensing push rod 35 is not in contact with the sensor 14, the heating plate 13 is closed, the second push plate 36 is not in contact with the limiting caps 43 any more, each set of limiting caps 43 is clamped with the circular groove 16 under the action of the spring rod 41 when the roller 1 returns to the original position, at the moment, the roller 1 can rotate again, the set of brush plate 3 is not in use is positioned right above the magnetic suction part, and the brush plate 3 is continuously pressed, and sampling of conjunctival cells of the lower eyelid is completed.
After sampling is completed, recovering conjunctival cell samples attached to the silica gel brush hairs into a designated container through oscillation, then placing the silica gel brush hairs into an ultrasonic cleaner for disinfection and cleaning, and pressing 3 groups of brush plates 3 to be tightly attached to the roller 1 during cleaning to prevent water from entering the roller 1; and taking out after cleaning is finished, and without unlocking the roller 1, after the residual moisture on the silica gel brush is dried by the heating plate 13 to be heated, only the front end of the roller 1 is pressed lightly and pushed to one side of the connecting shaft 2, so that the three groups of brush plates 3 are unlocked.
Example 2
As shown in fig. 1, a conjunctival cell brush for eye conjunctival cell sampling convenient to adjust, including cylinder 1 and connecting axle 2, the both ends face of cylinder 1 is regular triangle-shaped, and every side of cylinder 1 is the same size and is the rectangle, and every side of cylinder 1 all is equipped with a set of mobilizable brush board 3, and brush board 3 surface is equipped with the brush hair, and the brush hair is the silica gel material, and the size of brush board 3 is the same with the side size of cylinder 1, and the front end of connecting axle 2 runs through the terminal surface center of cylinder 1 and rotates with cylinder 1 to be connected, and cylinder 1 inside cavity sets up, and connecting axle 2 end is equipped with handle 5, and handle 5 and connecting axle 2 can dismantle the setting.
As shown in fig. 2-7 and 10, one end of the brush plate 3 near the connecting shaft 2 is provided with a limiting block 31 for preventing the brush plate 3 from separating from the roller 1, the limiting block 31 penetrates through the side surface of the roller 1 and extends into the roller 1, the center of the bottom of the brush plate 3 at one side of the limiting block 31 is provided with a magnetic suction plate 32 for fixing the brush plate 3 and the roller 1 with the connecting shaft 2, the position of the connecting shaft 2 corresponding to the magnetic suction plate 32 is provided with a circle of magnetic suction part 21 for mutually attracting and attaching with the magnetic suction plate 32, the end surface of the magnetic suction plate 32 is in a circular arc shape, two sides of the end surface of the magnetic suction plate 32 are provided with anti-skid parts 33, the surfaces of the anti-skid parts 33 are provided with anti-skid stripes, the anti-skid stripes are in a plurality of transverse wave lines, the center of the inner side surface of the roller 1 at one side of the magnetic suction plate 32 is provided with two groups of reset plates 11, each group of reset plates 11 are connected with the inner side surface of the roller 1 through springs 12, a first push plate 34 penetrating through the side surface of the roller 1 is arranged at the position corresponding to the brush plate 3 and the reset plates 11, two groups of springs 12 are arranged on two sides of the first push plate 34 respectively, the springs 12 drive the reset plates 11 to push the first push plate 34 away from the inner side surface of the roller 1, a limiting block 31 is attached to the inner side surface of the roller 1, a heating plate 13 is arranged at the center of the inner side surface of the roller 1 in the middle of the two groups of reset plates 11, the heating plate 13 is an inner structure of the roller 1, the shape structure of which is adjusted by the commercially available nano microcrystalline infrared heating plate, an inductor 14 is arranged on one side of the heating plate 13, and an induction push rod 35 for triggering the switch of the inductor 14 after the brush plate 3 and the inductor 14 are arranged at the position corresponding to the inductor 14.
As shown in fig. 2, 3, 8 and 9, a limiting part 4 for limiting the transverse sliding between the connecting shaft 2 and the roller 1 is arranged at the position of the connecting shaft 2 near the forefront end, and a movable groove 15 for movably matching with the tail end of the connecting shaft 2 is arranged at the position of the inner part of the roller 1 corresponding to the limiting part 4; the diameter of the connecting shaft 2 where the limiting part 4 is located is 2/3 of the diameter of the connecting shaft 2 of other parts, the limiting part 4 is arranged in an annular groove 22 at the front end of the connecting shaft 2, a round groove 16 is formed in the roller 1 corresponding to the annular groove 22, the limiting part 4 comprises a plurality of spring rods 41 which are circumferentially arranged, sleeve rods 42 which are arranged at the outer ends of the spring rods 41 in a sliding mode, limiting caps 43 which are fixedly arranged at the tail ends of the sleeve rods 42, the upper surfaces of the limiting caps 43 are arc-shaped, two side surfaces of the limiting caps 43 are plane surfaces, the middle parts of the sleeve rods 42 are sequentially connected into a whole through a group of connecting rods 44, a second push plate 36 penetrating through the side surface of the roller 1 is arranged at the position of the brush plate 3 corresponding to the limiting part 4, and the second push plate 36 extends into the round groove 16 to push the limiting caps 43 so that each group of sleeve rods 42 synchronously slide inwards along the spring rods 41.
As shown in fig. 3, the limiting block 31, the magnetic attraction plate 32, the first push plate 34, the induction push rod 35 and the second push plate 36 are all in sealing and sliding connection with the roller 1.
The method for sampling conjunctival cells of a sampled person by using the conjunctival cell brush comprises the following steps and working principles:
the working principle of this embodiment is basically the same as that of embodiment 1, except that:
the brush hair is silica gel brush hair, can not take place the phenomenon of falling the hair, and laminate at brush board 3 surface through the viscose for a monoblock brush, after the sample is accomplished at every turn, need tear a whole piece of brush, the new brush of renewing can.
Example 3
As shown in fig. 1, a conjunctival cell brush for eye conjunctival cell sampling is convenient for adjust, including cylinder 1 and connecting axle 2, the both ends face of cylinder 1 is regular triangle-shaped, and every side of cylinder 1 is the same size and is the rectangle, and connecting axle 2 middle part is folding telescopic link setting, and every side of cylinder 1 all is equipped with a set of mobilizable brush board 3, and brush board 3 surface is equipped with the brush hair, and the brush hair is silica gel material, and the size of brush board 3 is the same with the side size of cylinder 1, and the front end of connecting axle 2 runs through the terminal surface center of cylinder 1 and rotates with cylinder 1 to be connected, and cylinder 1 inside cavity sets up, and connecting axle 2 end is equipped with handle 5, and handle 5 and connecting axle 2 can dismantle the setting.
As shown in fig. 2-7 and 10, one end of the brush plate 3 near the connecting shaft 2 is provided with a limiting block 31 for preventing the brush plate 3 from separating from the roller 1, the limiting block 31 penetrates through the side surface of the roller 1 and extends into the roller 1, the center of the bottom of the brush plate 3 at one side of the limiting block 31 is provided with a magnetic suction plate 32 for fixing the brush plate 3 and the roller 1 with the connecting shaft 2, the position of the connecting shaft 2 corresponding to the magnetic suction plate 32 is provided with a circle of magnetic suction part 21 for mutually attracting and attaching with the magnetic suction plate 32, the end surface of the magnetic suction plate 32 is in a circular arc shape, two sides of the end surface of the magnetic suction plate 32 are provided with anti-skid parts 33, the surfaces of the anti-skid parts 33 are provided with anti-skid stripes, the anti-skid stripes are in a plurality of transverse wave lines, the center of the inner side surface of the roller 1 at one side of the magnetic suction plate 32 is provided with two groups of reset plates 11, each group of reset plates 11 are connected with the inner side surface of the roller 1 through springs 12, a first push plate 34 penetrating through the side surface of the roller 1 is arranged at the position corresponding to the brush plate 3 and the reset plates 11, two groups of springs 12 are arranged on two sides of the first push plate 34 respectively, the springs 12 drive the reset plates 11 to push the first push plate 34 away from the inner side surface of the roller 1, a limiting block 31 is attached to the inner side surface of the roller 1, a heating plate 13 is arranged at the center of the inner side surface of the roller 1 in the middle of the two groups of reset plates 11, the heating plate 13 is an inner structure of the roller 1, the shape structure of which is adjusted by the commercially available nano microcrystalline infrared heating plate, an inductor 14 is arranged on one side of the heating plate 13, and an induction push rod 35 for triggering the switch of the inductor 14 after the brush plate 3 and the inductor 14 are arranged at the position corresponding to the inductor 14.
As shown in fig. 2, 3, 8 and 9, a limiting part 4 for limiting the transverse sliding between the connecting shaft 2 and the roller 1 is arranged at the position of the connecting shaft 2 near the forefront end, and a movable groove 15 for movably matching with the tail end of the connecting shaft 2 is arranged at the position of the inner part of the roller 1 corresponding to the limiting part 4; the diameter of the connecting shaft 2 where the limiting part 4 is located is 1/2 of the diameter of the connecting shaft 2 of other parts, the limiting part 4 is arranged in an annular groove 22 at the front end of the connecting shaft 2, a round groove 16 is formed in the roller 1 corresponding to the annular groove 22, the limiting part 4 comprises a plurality of spring rods 41 which are circumferentially arranged, sleeve rods 42 which are arranged at the outer ends of the spring rods 41 in a sliding mode, limiting caps 43 which are fixedly arranged at the tail ends of the sleeve rods 42, the upper surfaces of the limiting caps 43 are arc-shaped, two side surfaces of the limiting caps 43 are plane surfaces, the middle parts of the sleeve rods 42 are sequentially connected into a whole through a group of connecting rods 44, a second push plate 36 penetrating through the side surface of the roller 1 is arranged at the position of the brush plate 3 corresponding to the limiting part 4, and the second push plate 36 extends into the round groove 16 to push the limiting caps 43 so that each group of sleeve rods 42 synchronously slide inwards along the spring rods 41.
As shown in fig. 3, the limiting block 31, the magnetic attraction plate 32, the first push plate 34, the induction push rod 35 and the second push plate 36 are all in sealing and sliding connection with the roller 1.
The method for sampling conjunctival cells of a sampled person by using the conjunctival cell brush comprises the following steps and working principles:
the working principle of this embodiment is basically the same as that of embodiment 1, except that:
when the multifunctional conjunctiva cytobrush is used, the connecting shaft 2 is unfolded through folding, the length of the connecting shaft 2 is adjusted through telescoping, and meanwhile, the connecting shaft 2 is folded and folded after the multifunctional conjunctiva cytobrush is used, so that the conjunctiva cytobrush is more convenient to carry, and meanwhile, the connecting shaft 2 can be stretched when a stored cell sample is transferred, so that the roller 1 and the brush plate 3 can be deeply penetrated into a cell preservation solution in a collection test tube for collection.
Example 4
The embodiment is basically the same as the embodiment 1, except that the 3 groups of brush boards 3 are integrally arranged, and a sterile film for wrapping the handle 5 and the connecting shaft 2 is arranged at the position of the brush boards 3 close to the handle 5 to prevent the brush boards 3 from being polluted by bacteria;
when using, integral brush board is changed more conveniently, when depositing the cell on the brush board 3 in collecting the test tube, it makes the cell sample on the brush board 3 evenly drop to collecting the test tube and can not lead to the fact the damage to the membranous cell under the ultrasonic vibration's the condition to add to establish ultrasonic device in collecting the outer bottom of test tube, set up the vibrator in cylinder 1 simultaneously, it is commercially available cell-phone vibrator, including a miniature ordinary motor with an eccentric wheel for with the cell vibration drop when depositing the cell, can realize breaking away from the cell from the brush board fast.
Claims (9)
1. The conjunctival cell brush for eye conjunctival cell sampling convenient to adjust is characterized by comprising a roller (1) and a connecting shaft (2), wherein two end faces of the roller (1) are regular triangles, each side face of the roller (1) is rectangular in size, each side face of the roller (1) is provided with a group of movable brush plates (3), the size of each brush plate (3) is identical to that of the side face of the roller (1), and the front end of the connecting shaft (2) penetrates through the center of one end face of the roller (1) and is connected with the roller (1) in a rotating mode, and the interior of the roller (1) is hollow;
the utility model discloses a magnetic induction type electric heater, which is characterized in that a limiting block (31) used for preventing the brush plate (3) from separating from a roller (1) is arranged at one end of a connecting shaft (2) near the center of the bottom of the brush plate (3), the limiting block (31) penetrates through the side surface of the roller (1) and extends to the inside of the roller (1), a magnetic suction plate (32) used for fixing the brush plate (3) and the roller (1) with the connecting shaft (2) is arranged at the center of the bottom of the brush plate (3), a circle of magnetic suction part (21) used for mutually attracting and attaching with the magnetic suction plate (32) is arranged at the corresponding position of the connecting shaft (2), the end surface of the magnetic suction plate (32) is arranged in a circular arc shape, anti-slip parts (33) are arranged at two sides of the end surface of the magnetic suction plate (32), two groups of reset plates (11) are arranged at the center of the inner side surface of the roller (1) on one side of the magnetic suction plate (32), each group of reset plates (11) are connected with the inner side surface of the roller (1) through springs (12), a first heating plate (34) penetrating through the roller (1) is arranged at the corresponding position of the brush plate (3) and the reset plate (11), a first heating plate (13) is arranged at the center of the inner side surface of the roller (13), an induction push rod (35) for triggering the switch of the inductor (14) after moving is arranged at the position of the brush plate (3) corresponding to the inductor (14);
a limiting part (4) for limiting the transverse sliding between the connecting shaft (2) and the roller (1) is arranged at the position, close to the forefront end, of the connecting shaft (2), and a movable groove (15) for being movably matched with the tail end of the connecting shaft (2) is arranged at the position, corresponding to the limiting part (4), inside the roller (1);
the outer surface of the brush plate (3) is provided with brush hair.
2. The conjunctival cell brush for ocular conjunctival cell sampling which is convenient to adjust according to claim 1, wherein the tail end of the connecting shaft (2) is provided with a handle (5), and the handle (5) is detachably arranged with the connecting shaft (2).
3. The conjunctival cell brush for eye conjunctival cell sampling which is convenient to adjust according to claim 1, wherein the spring (12) drives the reset plate (11) to push the first push plate (34) away from the inner side surface of the roller (1), and the limiting block (31) is attached to the inner side surface of the roller (1).
4. The conjunctival cell brush for ocular conjunctival cell sampling which is convenient to adjust according to claim 1, wherein the surface of the anti-slip part (33) is provided with anti-slip stripes which are arranged in a plurality of transverse wavy lines.
5. The conjunctival cell brush for ocular conjunctival cell sampling of easy adjustment of claim 1, wherein the springs (12) are arranged in two groups and are respectively arranged at two sides of the first push plate (34).
6. The conjunctival cell brush convenient to adjust for eye conjunctival cell sampling according to claim 1, wherein the diameter of the connecting shaft (2) where the limiting part (4) is located is smaller than that of other connecting shafts (2), the limiting part (4) is arranged in an annular groove (22) at the front end of the connecting shaft (2), a circular groove (16) is formed in the drum (1) corresponding to the annular groove (22), the limiting part (4) comprises a plurality of spring rods (41) circumferentially arranged, sleeve rods (42) are slidably arranged at the outer ends of the spring rods (41), limiting caps (43) fixedly arranged at the tail ends of the sleeve rods (42), the middle parts of each sleeve rod (42) are sequentially connected into a whole through a group of connecting rods (44), a second pushing plate (36) penetrating through the side face of the drum (1) is arranged at the position corresponding to the limiting part (4), and the second pushing plate (36) extends into the circular groove (16) to push the sleeve rods (42) so as to enable each sleeve rod (42) to synchronously slide inwards along the spring rods (41).
7. The conjunctival cell brush for eye conjunctival cell sampling of claim 6, wherein the limiting block (31), the magnetic attraction plate (32), the first pushing plate (34), the induction pushing rod (35) and the second pushing plate (36) are all in sealing and sliding connection with the roller (1).
8. The conjunctival cell brush for ocular conjunctival cell sampling which is convenient to adjust according to claim 6, wherein the upper surface of the limiting cap (43) is arc-shaped, and two side surfaces of the limiting cap (43) are plane surfaces.
9. The conveniently adjusted conjunctival cell brush for ocular conjunctival cell sampling of claim 1, wherein the bristles are of silica gel or cotton.
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| CN202110801183.7A CN113576550B (en) | 2021-07-15 | 2021-07-15 | Conjunctival cell brush convenient to adjust and used for eye conjunctival cell sampling |
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| CN202110801183.7A CN113576550B (en) | 2021-07-15 | 2021-07-15 | Conjunctival cell brush convenient to adjust and used for eye conjunctival cell sampling |
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| CN113576550B true CN113576550B (en) | 2024-02-20 |
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| CN113576550A (en) | 2021-11-02 |
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