CN113576550A - Conjunctival cell brush convenient to adjust and used for eye conjunctival cell sampling - Google Patents
Conjunctival cell brush convenient to adjust and used for eye conjunctival cell sampling Download PDFInfo
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- CN113576550A CN113576550A CN202110801183.7A CN202110801183A CN113576550A CN 113576550 A CN113576550 A CN 113576550A CN 202110801183 A CN202110801183 A CN 202110801183A CN 113576550 A CN113576550 A CN 113576550A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/02—Instruments for taking cell samples or for biopsy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/02—Instruments for taking cell samples or for biopsy
- A61B2010/0216—Sampling brushes
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medical Informatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pathology (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
The invention discloses a conjunctival cell brush convenient to adjust and used for eye conjunctival cell sampling, which comprises a roller and a connecting shaft, wherein two end surfaces of the roller are regular triangles, each side surface of the roller is rectangular and has the same size, each side surface of the roller is provided with a group of movable brush plates, the size of each brush plate is the same as that of the side surface of the roller, the front end of the connecting shaft penetrates through the center of one end surface of the roller and is rotatably connected with the roller, the inside of the roller is arranged in a hollow manner, the connecting shaft is provided with a limiting part used for limiting the transverse sliding between the connecting shaft and the roller at the position close to the foremost end, and a movable groove used for movably matching with the tail end of the connecting shaft is arranged in the position corresponding to the limiting part in the roller. The conjunctiva cell brush provided by the invention realizes the reutilization of the conjunctiva cell brush, and the internal structure of the conjunctiva cell brush is reasonably arranged according to the eye structure characteristics of a person to be sampled, so that the aims of large sampling quantity, high sampling speed, intact cells, high cell separation speed, convenience in cleaning, greenness and no pollution are fulfilled.
Description
Technical Field
The invention relates to the technical field of ophthalmic conjunctival medical instruments, in particular to a conjunctival cell brush which is used for sampling conjunctival cells of eyes and is convenient to adjust.
Background
The conjunctiva is a layer of mucosa covering the insides of the upper and lower eyelids and in front of the eyeball, is a transparent film formed by multiple layers of columnar epithelium and a small amount of connective tissue, is a palpebral conjunctiva which is lined on the inner surface of the eyelid, is a bulbar conjunctiva which is attached in front of the eyeball, is continuous with each other, and has the function of protecting and facilitating the movement of the eyeball when the eyelid is closed, wherein a gap surrounded by the conjunctiva is called as a conjunctival sac. The turning part of the bulbar conjunctiva and the palpebral conjunctiva is called a fornix conjunctiva, the conjunctiva contains rich blood vessels and nerve endings, has a small amount of mucous glands, can secrete mucus and lubricate the eyeball so as to reduce the friction between the bulbar conjunctiva and the cornea, and chlamydia trachomatis mainly invades the bulbar conjunctiva and the fornix conjunctiva. Both acute bacterial and viral conjunctivitis are caused by bacterial and viral infection of the conjunctiva and are infectious.
The study of conjunctival cytology has been of great significance for the clinical diagnosis of conjunctival diseases, with conjunctival cells being studied as early as the 40 s by Thygeson, Norn, and the like, and much work has been done. The inspection method comprises wiping conjunctival surface with cotton stick or scraping conjunctival surface with blunt narrow knife, smearing the scraped material on glass slide, staining with Ji's or Rue's stain, and qualitatively analyzing to observe conjunctival epithelial cell components. In 1950 Norn further used quantitative analysis, using a glass pipette with a rubber ball at one end, the length of the pipette being 10cm and the diameter being 1.5mm, sucking secretion from the outside of the conjunctival fornix, applying the sucked liquid on a glass slide, and staining and microscopic examination of the cell components.
Conjunctival scraping or smearing is made by taking conjunctival epithelial secretion cells, and plays a key role in diagnosis and treatment of the following diseases, namely, xerophthalmia: keratotic granules of epithelial cells and a large number of xerosis are found by the examination of the bulbar conjunctiva upper scraping sheet; heat of the pharynx conjunctiva: a large amount of mononuclear cells are scraped in the conjunctiva, and no bacteria grow in the culture; vernal conjunctivitis: the conjunctival scrape contains eosinophils or eosinophils; epidemic keratoconjunctivitis: the fluorescein is added for marking the antibody, so that the virus antigen exists in the infected epithelial cell in almost all cases; inclusion body conjunctivitis: inclusion bodies were visible in the conjunctival scraping.
The sampling of conjunctival cells is an essential step for the study of conjunctival cells, and the existing conjunctival cell sampling methods include: the method comprises the following steps of (1) cutting a conjunctival epithelial tissue block, scraping a conjunctival epithelial cell scraper and a conjunctival imprinted cell sample, wherein the cutting of the conjunctival epithelial tissue block needs to be performed on a patient after anesthesia, and is easy to cause infection; the conjunctival-imprinted cell sample is prepared by attaching a sterile conjunctival cell test strip to the bulbar conjunctiva under the eyeball of a subject, but the test strip is easy to cause discomfort or allergic reaction when placed in the eyeball of the subject for a long time. Therefore, the conjunctival cell brush is convenient to use, can obtain deeper cells, and has a good development prospect.
The sampling of conjunctival cells is an essential step for the study of conjunctival cells, and the existing conjunctival cell sampling methods include: conjunctival epithelial cell scraping and conjunctival imprinted cell samples are commonly used, wherein the conjunctival epithelial cell scraping is dangerous to operate, has large damage to cells and is easy to cause infection; the conjunctival imprinted cell sample is prepared by attaching sterile conjunctival cell test paper to different parts of the bulbar conjunctiva of a subject for multiple times, is complex to operate and takes much time, and has large influence on cells and easily causes the reduction of the cell survival rate because the cells and the cell test paper are firmly attached and need to be oscillated for a long time. Therefore, conjunctival cells can be conveniently and rapidly brushed by the conjunctival cell brush, and the conjunctival cell brush has a good development prospect.
Disclosure of Invention
In view of the above-mentioned problems, the present invention provides a conjunctival cell brush for ocular conjunctival cell sampling, which is easy to adjust.
The technical scheme of the invention is as follows:
a conjunctival cell brush convenient to adjust and used for eye conjunctival cell sampling comprises a roller and a connecting shaft, wherein two end faces of the roller are regular triangles, each side face of the roller is rectangular and has the same size, each side face of the roller is provided with a group of movable brush plates, the size of each brush plate is the same as that of the side face of the roller, the front end of the connecting shaft penetrates through the center of one end face of the roller and is rotatably connected with the roller, and the inside of the roller is arranged in a hollow mode;
a limiting block for preventing the brush plate from separating from the roller is arranged at one end of the center of the bottom of the brush plate, which is close to the connecting shaft, the limiting block penetrates through the side surface of the roller and extends into the roller, a magnetic suction plate for fixing the brush plate and the roller with the connecting shaft is arranged at the center of the bottom of the brush plate at one side of the limiting block, a circle of magnetic suction part for mutually attracting and jointing the magnetic suction plate is arranged at the position of the connecting shaft corresponding to the magnetic suction plate, the end surface of the magnetic suction plate is arranged in a circular arc shape, anti-slip parts are arranged at two sides of the end surface of the magnetic suction plate, two groups of reset plates are arranged at the center of the inner side surface of the roller at one side of the magnetic suction plate, each group of reset plates is connected with the inner side surface of the roller through springs, a first push plate penetrating through the side surface of the roller is arranged at the position of the brush plate corresponding to the reset plates, a heating plate is arranged at the center of the inner side surface of the roller between the two groups of reset plates, and one side of the heating plate is provided with an inductor, an induction push rod for triggering the inductor switch after movement is arranged at the position, corresponding to the inductor, of the brush plate;
a limiting part for limiting the transverse sliding between the connecting shaft and the roller is arranged at the position, close to the foremost end, of the connecting shaft, and a movable groove for movably matching with the tail end of the connecting shaft is arranged in the roller at a position corresponding to the limiting part;
the outer surface of the brush plate is provided with brush hair.
Furthermore, the handle is arranged at the tail end of the connecting shaft and detachably arranged with the connecting shaft, so that the roller and the brush plate can be replaced more conveniently.
Further, the spring drives the reset plate to push the first push plate away from the inner side surface of the roller, and the limiting block is attached to the inner side surface of the roller, so that the brush plate is prevented from being separated from the roller through the limiting plate.
Furthermore, the surface of the anti-skid part is provided with anti-skid stripes which are arranged by a plurality of transverse wave lines, so that the anti-skid part has larger friction force on the longitudinal direction and smaller friction force on the transverse direction, the brush plate is more firmly fixed when being locked, and meanwhile, the unlocking is convenient.
Furthermore, the springs are two groups and are respectively positioned on two sides of the first push plate, so that the brush plate can be locked and reset conveniently.
Furthermore, the diameter of the connecting shaft where the limiting part is positioned is smaller than that of the connecting shafts of other parts, the limiting part is arranged in an annular groove at the front end of the connecting shaft, a circular groove is arranged in the roller corresponding to the annular groove, the limiting part comprises a plurality of spring rods arranged along the circumferential direction, loop bars arranged at the outer ends of the spring rods in a sliding way, limiting caps fixedly arranged at the tail ends of the loop bars, the middle parts of each set of loop bars are connected into a whole through a set of connecting rods in sequence, a second push plate penetrating through the side surface of the roller is arranged at the position of the brush plate corresponding to the limiting part, the second push plate extends into the circular groove and is used for pushing the limiting cap to enable each group of loop bars to synchronously slide inwards along the spring rod, the arrangement of the limiting part can enable the roller and the connecting shaft to rotate relatively, and the roller and the connecting shaft can be locked and then unlocked conveniently, so that conjunctival cells can be collected smoothly.
Furthermore, the limiting block, the magnetic suction plate, the first push plate, the induction push rod and the second push plate are all connected with the roller in a sealing and sliding mode, and therefore sundries are prevented from entering the roller or water enters the roller to damage the internal structure.
Preferably, the upper surface of spacing cap is the arc setting, and the both sides face of spacing cap is the plane setting, makes things convenient for the second push pedal to promote spacing cap, and spacing cap side prevents that the cylinder from sliding.
Furthermore, the brush hair is silica gel material or cotton material, can select suitable brush hair material as required, is favorable to the intact of conjunctiva cell collection sample.
The invention has the beneficial effects that:
(1) the conjunctiva cell brush is used for sampling conjunctiva cells of eyes, a disposable sampling brush is not used, the conjunctiva cell brush is recycled, the internal structure of the conjunctiva cell brush is reasonably arranged according to the structural characteristics of the conjunctiva cells and the eyes of a person to be sampled, the purposes of large sampling quantity, high sampling speed, intact cells, high cell separation speed, convenience in cleaning, greenness and no pollution are achieved, sterile operation can be realized, and clinical use is facilitated.
(2) According to the conjunctival cell brush, the contact area of the sample is greatly increased compared with the design of a pure cylinder through the design of the triangular rectangles of the brush plate and the roller, so that the number of the taken cell samples is larger, conjunctival cells are attached to each surface, the phenomenon that the cells are repeatedly scraped from the same surface to cause cell death is avoided, the survival rate of the conjunctival cells is improved, the roller can be locked and stopped rotating through pressing the brush plate, the use is convenient and fast, and the workload of medical research workers is reduced.
(3) The conjunctiva cell brush can heat the brush plate to the surface temperature through the heating plate arranged in the roller, thereby improving the body feeling of a sampled person and reducing the discomfort of the sampled person.
(4) The conjunctiva cell brush provided by the invention can well fix the roller and can rotate through the limiting part, and the limiting part can contract by matching with the second push plate, so that the locking and unlocking of the roller are completed, and the operation is simple and effective.
(5) The conjunctiva cell brush can be used for washing the whole body by water or ultrasonic after the brush plate is locked, the brush hair is made of silica gel or cotton materials according to the requirement, the washing and the disinfection are cleaner, the replacement is convenient, and water or sundries are not easy to enter the inside of the roller so as to prevent the structure inside the roller from being damaged.
Drawings
FIG. 1 is a schematic view of the whole structure of a conjunctival cell brush of the present invention;
FIG. 2 is a schematic view of the internal structure of the conjunctival cell brush of the invention;
FIG. 3 is a bottom view of a brush plate of the conjunctival cell brush of the invention;
FIG. 4 is a sectional view of the roller at the position of the limiting block of the conjunctival cell brush of the invention;
FIG. 5 is a cross-sectional view of the roller at the position of the magnetic attraction plate of the conjunctiva cell brush of the invention;
FIG. 6 is a cross-sectional view of the roller at the position of the return plate of the conjunctival cell brush of the invention;
FIG. 7 is a cross-sectional view of the roller at the position of the heating plate of the conjunctival cell brush of the invention;
FIG. 8 is a schematic view showing the structure of the front end limiting part of the connecting shaft of the conjunctiva cell brush of the present invention;
FIG. 9 is a sectional view of the roller at the position of the position limiting part of the conjunctival cell brush of the invention;
FIG. 10 is a schematic view showing the structure of the anti-slip part of the conjunctival cell brush of the present invention.
The device comprises a roller 1, a reset plate 11, a spring 12, a heating plate 13, a sensor 14, a movable groove 15, a circular groove 16, a connecting shaft 2, a magnetic attraction part 21, an annular groove 22, a brush plate 3, a limiting block 31, a magnetic attraction plate 32, an anti-slip part 33, a first push plate 34, a sensing push rod 35, a second push plate 36, a limiting part 4, a spring rod 41, a sleeve rod 42, a limiting cap 43, a connecting rod 44 and a handle 5.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and the terms "front, back", "left, and right" used in the embodiments of the present invention are only used for descriptive purposes, and are not to be construed as indicating or implying relative importance or implicitly indicating the location of the indicated technical features.
Example 1
As shown in fig. 1, a conjunctiva cell brush that is used for eye conjunctiva cell sample to be convenient for adjust, including cylinder 1 and connecting axle 2, the both ends face of cylinder 1 is regular triangle, every side size of cylinder 1 is the same and is the rectangle, every side of cylinder 1 all is equipped with a set of mobilizable brush board 3, brush board 3 surface is equipped with the brush hair, the brush hair is the silica gel material, the size of brush board 3 is the same with the side size of cylinder 1, the front end of connecting axle 2 runs through a terminal surface center of cylinder 1 and rotates with cylinder 1 to be connected, the inside cavity of cylinder 1 sets up, 2 ends of connecting axle are equipped with handle 5, handle 5 can dismantle the setting with connecting axle 2.
As shown in fig. 2-7 and 10, a limit block 31 for preventing the brush plate 3 from separating from the roller 1 is disposed at a position close to one end of the connecting shaft 2 at the center of the bottom of the brush plate 3, the limit block 31 penetrates through the side surface of the roller 1 and extends into the roller 1, a magnetic attraction plate 32 for fixing the brush plate 3 and the roller 1 with the connecting shaft 2 is disposed at the center of the bottom of the brush plate 3 at one side of the limit block 31, a circle of magnetic attraction part 21 for mutually attracting and attaching with the magnetic attraction plate 32 is disposed at a position corresponding to the magnetic attraction plate 32 of the connecting shaft 2, the end surface of the magnetic attraction plate 32 is arranged in a circular arc shape, anti-slip parts 33 are disposed at two sides of the end surface of the magnetic attraction plate 32, anti-slip stripes are disposed on the surface of the anti-slip parts 33, the anti-slip stripes are disposed as a plurality of transverse wave lines, two sets of reset plates 11 are disposed at the center of the inner side surface of the roller 1 at one side of the magnetic attraction plate 32, each set of reset plate 11 is connected with the inner side surface of the roller 1 through a spring 12, a first push plate 34 penetrating through the side surface of the brush plate 3 and the reset plate 11, spring 12 is two sets of, and be located first push pedal 34 both sides respectively, spring 12 drives and resets board 11 and pushes away first push pedal 34 from 1 medial surface of cylinder and stopper 31 and 1 medial surface of cylinder laminate mutually, it is equipped with hot plate 13 to be located 1 medial surface center department of cylinder in the middle of two sets of boards 11 that reset, hot plate 13 is the inner structure of nano microcrystal infrared heating board through appearance structure adjustment with adaptation cylinder 1 on the market, hot plate 13 one side is equipped with inductor 14, brush board 3 is equipped with the response push rod 35 that is used for the activity after-triggering inductor 14 switch with inductor 14 corresponding position department.
As shown in fig. 2, 3, 8 and 9, a limiting part 4 for limiting the transverse sliding between the connecting shaft 2 and the roller 1 is arranged at the position of the connecting shaft 2 close to the most front end, and a movable groove 15 for movably matching with the tail end of the connecting shaft 2 is arranged at the position of the roller 1 corresponding to the limiting part 4; the diameter of connecting axle 2 department at spacing 4 place is 3/4 of other part connecting axle 2 diameters, spacing 4 sets up in the ring channel 22 of connecting axle 2 front end, the inside circular slot 16 that is equipped with of cylinder 1 that corresponds with ring channel 22, spacing 4 includes a plurality of spring bars 41 that circumference was equipped with, be located the loop bar 42 that spring bar 41 outer end slided and set up, be located the terminal fixed spacing cap 43 that sets up of loop bar 42, the upper surface of spacing cap 43 is the arc setting, the both sides face of spacing cap 43 is the plane setting, the middle part of every group loop through a set of connecting rod 44 and connect into a whole, brush board 3 is equipped with the second push pedal 36 that runs through the cylinder 1 side with spacing 4 corresponding position department, second push pedal 36 extends to and is used for promoting in the circular slot 16 spacing cap 43 and makes every group loop bar 42 synchronous along the inboard slip of spring bar 41.
As shown in fig. 3, the limiting block 31, the magnetic attraction plate 32, the first push plate 34, the sensing push rod 35, and the second push plate 36 are all connected to the drum 1 in a sealing and sliding manner.
The method for sampling the conjunctival cells of the person to be sampled by using the conjunctival cell brush comprises the following steps of:
when the disposable glove type conjunctiva scraping device is used, firstly, a medical worker wears disposable gloves, holds the handle 5, rotates the roller 1 to the brush plate 3 to rotate to a proper position, namely, the brush plate 3 which needs to scrape conjunctival cells is positioned right below, then presses the brush plate 3 to enable the brush plate 3 to be tightly attached to the roller 1, the roller 1 is locked and can not rotate around the connecting shaft 2, and then the medical worker reversely rotates the upper eyelid of a sampled person to scrape conjunctival cells and sample.
The working principle of the brush plate 3 is as follows:
when the brush plate 3 is pressed, the limiting block 31 moves towards the inner space of the roller 1 to remove the limiting; the magnetic suction plate 32 moves towards the inner space of the roller 1 until the magnetic suction plate is butted with the magnetic suction part 21 on the connecting shaft 2, and is attracted and attached, and the magnetic suction plate 32 is prevented from moving back and forth under the action of the anti-slip part 33, namely the roller 1 stops rotating; the first push plate 34 moves towards the inner space of the roller 1 and pushes the reset plate 11 to move, and the reset plate 11 moves towards the inner part of the roller 1 for a certain distance under the action of the spring; the induction push rod 35 moves towards the inner space of the roller 1 until the induction push rod 35 is contacted with the inductor 14, and the switch of the heating plate 13 is triggered, so that the heating plate 13 starts to work to heat the brush plate 3 and the bristles;
the working principle of the limiting part 4 is as follows:
meanwhile, in the process of pressing the brush plate 3, the second push plate 36 moves into the circular groove 16 in the roller 1 until contacting with 2-3 groups of limit caps 43 corresponding to the second push plate 36, and pushes the 2-3 groups of limit caps 43 into the annular groove 22, because each group of loop bars 42 are connected through the connecting rod 44, all the loop bars 42 drive the limit caps 43 to move into the annular groove 22 along the spring rod 41, so that the side surfaces of the limit caps 43 are not contacted with the side walls of the circular groove 16 any more, and are contacted with the limit in the transverse direction;
when a group of conjunctiva cells are sampled, the conjunctiva cells of the lower eyelid need to be sampled, the contact roller 1 needs to be locked, the front end of the roller 1 is pressed to slightly push towards one side of the connecting shaft 2, the front end of the connecting shaft 2 extends into the movable groove 15 under the action of the anti-slip part 33, the magnetic attraction plate 32 is not in contact with the magnetic attraction part 21, at the moment, the reset plate 11 resets under the action of the spring 12, the first push plate 34 is pushed away from the inside of the roller 1, the limiting block 31 is clamped with the inner side surface of the roller 1, the induction push rod 35 is not in contact with the inductor 14, the heating plate 13 is closed, the second push plate 36 is not in contact with the limiting cap 43, each group of limiting caps 43 pops out under the action of the spring rod 41 to be clamped with the circular groove 16 when the roller 1 returns to the original position, at the moment, the roller 1 can rotate again to rotate until an unused group of brush plates 3 is positioned right above, and continue to press the brush plates 3, and (4) completing the conjunctival cell sampling of the lower eyelid.
After sampling is finished, conjunctival cell samples attached to the silica gel brush hairs are recovered to a designated container through oscillation, then the silica gel brush hairs are put into an ultrasonic cleaning machine for disinfection and cleaning, and during cleaning, 3 groups of brush plates 3 are pressed to be tightly attached to the roller 1, so that water is prevented from entering the roller 1; and taking out after the cleaning is finished without unlocking the roller 1, and slightly pushing the front end of the roller 1 to one side of the connecting shaft 2 after the residual moisture on the silica gel brush is dried by the heating plate 13 to be heated so as to unlock the three groups of brush plates 3.
Example 2
As shown in fig. 1, a conjunctiva cell brush that is used for eye conjunctiva cell sample to be convenient for adjust, including cylinder 1 and connecting axle 2, the both ends face of cylinder 1 is regular triangle, every side size of cylinder 1 is the same and is the rectangle, every side of cylinder 1 all is equipped with a set of mobilizable brush board 3, brush board 3 surface is equipped with the brush hair, the brush hair is the silica gel material, the size of brush board 3 is the same with the side size of cylinder 1, the front end of connecting axle 2 runs through a terminal surface center of cylinder 1 and rotates with cylinder 1 to be connected, the inside cavity of cylinder 1 sets up, 2 ends of connecting axle are equipped with handle 5, handle 5 can dismantle the setting with connecting axle 2.
As shown in fig. 2-7 and 10, a limit block 31 for preventing the brush plate 3 from separating from the roller 1 is disposed at a position close to one end of the connecting shaft 2 at the center of the bottom of the brush plate 3, the limit block 31 penetrates through the side surface of the roller 1 and extends into the roller 1, a magnetic attraction plate 32 for fixing the brush plate 3 and the roller 1 with the connecting shaft 2 is disposed at the center of the bottom of the brush plate 3 at one side of the limit block 31, a circle of magnetic attraction part 21 for mutually attracting and attaching with the magnetic attraction plate 32 is disposed at a position corresponding to the magnetic attraction plate 32 of the connecting shaft 2, the end surface of the magnetic attraction plate 32 is arranged in a circular arc shape, anti-slip parts 33 are disposed at two sides of the end surface of the magnetic attraction plate 32, anti-slip stripes are disposed on the surface of the anti-slip parts 33, the anti-slip stripes are disposed as a plurality of transverse wave lines, two sets of reset plates 11 are disposed at the center of the inner side surface of the roller 1 at one side of the magnetic attraction plate 32, each set of reset plate 11 is connected with the inner side surface of the roller 1 through a spring 12, a first push plate 34 penetrating through the side surface of the brush plate 3 and the reset plate 11, spring 12 is two sets of, and be located first push pedal 34 both sides respectively, spring 12 drives and resets board 11 and pushes away first push pedal 34 from 1 medial surface of cylinder and stopper 31 and 1 medial surface of cylinder laminate mutually, it is equipped with hot plate 13 to be located 1 medial surface center department of cylinder in the middle of two sets of boards 11 that reset, hot plate 13 is the inner structure of nano microcrystal infrared heating board through appearance structure adjustment with adaptation cylinder 1 on the market, hot plate 13 one side is equipped with inductor 14, brush board 3 is equipped with the response push rod 35 that is used for the activity after-triggering inductor 14 switch with inductor 14 corresponding position department.
As shown in fig. 2, 3, 8 and 9, a limiting part 4 for limiting the transverse sliding between the connecting shaft 2 and the roller 1 is arranged at the position of the connecting shaft 2 close to the most front end, and a movable groove 15 for movably matching with the tail end of the connecting shaft 2 is arranged at the position of the roller 1 corresponding to the limiting part 4; the diameter of connecting axle 2 department at spacing 4 place is 2/3 of other part connecting axle 2 diameters, spacing 4 sets up in the ring channel 22 of connecting axle 2 front end, the inside circular slot 16 that is equipped with of cylinder 1 that corresponds with ring channel 22, spacing 4 includes a plurality of spring bars 41 that circumference was equipped with, be located the loop bar 42 that spring bar 41 outer end slided and set up, be located the terminal fixed spacing cap 43 that sets up of loop bar 42, the upper surface of spacing cap 43 is the arc setting, the both sides face of spacing cap 43 is the plane setting, the middle part of every group loop through a set of connecting rod 44 and connect into a whole, brush board 3 is equipped with the second push pedal 36 that runs through the cylinder 1 side with spacing 4 corresponding position department, second push pedal 36 extends to and is used for promoting in the circular slot 16 spacing cap 43 and makes every group loop bar 42 synchronous along the inboard slip of spring bar 41.
As shown in fig. 3, the limiting block 31, the magnetic attraction plate 32, the first push plate 34, the sensing push rod 35, and the second push plate 36 are all connected to the drum 1 in a sealing and sliding manner.
The method for sampling the conjunctival cells of the person to be sampled by using the conjunctival cell brush comprises the following steps of:
the working principle of this embodiment is basically the same as that of embodiment 1, and the difference is that:
the brush hair is the silica gel brush hair, can not take place to fall the phenomenon of hair, and passes through the viscose laminating at 3 surfaces of brush board for a monoblock brush, and the sample is accomplished the back each time, need tear a whole piece brush, the brush of renewal can.
Example 3
As shown in fig. 1, a conjunctiva cell brush that is used for eye conjunctiva cell sample to be convenient for adjust, including cylinder 1 and connecting axle 2, the both ends face of cylinder 1 is regular triangle, every side size of cylinder 1 is the same and is the rectangle, 2 middle parts of connecting axle are folding telescopic link setting, every side of cylinder 1 all is equipped with a set of mobilizable brush board 3, 3 surfaces of brush board are equipped with the brush hair, the brush hair is the silica gel material, the size of brush board 3 is the same with the side size of cylinder 1, the front end of connecting axle 2 runs through a terminal surface center of cylinder 1 and rotates with cylinder 1 to be connected, the inside cavity of cylinder 1 sets up, 2 end of connecting axle are equipped with handle 5, handle 5 can dismantle the setting with connecting axle 2.
As shown in fig. 2-7 and 10, a limit block 31 for preventing the brush plate 3 from separating from the roller 1 is disposed at a position close to one end of the connecting shaft 2 at the center of the bottom of the brush plate 3, the limit block 31 penetrates through the side surface of the roller 1 and extends into the roller 1, a magnetic attraction plate 32 for fixing the brush plate 3 and the roller 1 with the connecting shaft 2 is disposed at the center of the bottom of the brush plate 3 at one side of the limit block 31, a circle of magnetic attraction part 21 for mutually attracting and attaching with the magnetic attraction plate 32 is disposed at a position corresponding to the magnetic attraction plate 32 of the connecting shaft 2, the end surface of the magnetic attraction plate 32 is arranged in a circular arc shape, anti-slip parts 33 are disposed at two sides of the end surface of the magnetic attraction plate 32, anti-slip stripes are disposed on the surface of the anti-slip parts 33, the anti-slip stripes are disposed as a plurality of transverse wave lines, two sets of reset plates 11 are disposed at the center of the inner side surface of the roller 1 at one side of the magnetic attraction plate 32, each set of reset plate 11 is connected with the inner side surface of the roller 1 through a spring 12, a first push plate 34 penetrating through the side surface of the brush plate 3 and the reset plate 11, spring 12 is two sets of, and be located first push pedal 34 both sides respectively, spring 12 drives and resets board 11 and pushes away first push pedal 34 from 1 medial surface of cylinder and stopper 31 and 1 medial surface of cylinder laminate mutually, it is equipped with hot plate 13 to be located 1 medial surface center department of cylinder in the middle of two sets of boards 11 that reset, hot plate 13 is the inner structure of nano microcrystal infrared heating board through appearance structure adjustment with adaptation cylinder 1 on the market, hot plate 13 one side is equipped with inductor 14, brush board 3 is equipped with the response push rod 35 that is used for the activity after-triggering inductor 14 switch with inductor 14 corresponding position department.
As shown in fig. 2, 3, 8 and 9, a limiting part 4 for limiting the transverse sliding between the connecting shaft 2 and the roller 1 is arranged at the position of the connecting shaft 2 close to the most front end, and a movable groove 15 for movably matching with the tail end of the connecting shaft 2 is arranged at the position of the roller 1 corresponding to the limiting part 4; the diameter of connecting axle 2 department at spacing 4 place is 1/2 of other part connecting axle 2 diameters, spacing 4 sets up in the ring channel 22 of connecting axle 2 front end, the inside circular slot 16 that is equipped with of cylinder 1 that corresponds with ring channel 22, spacing 4 includes a plurality of spring bars 41 that circumference was equipped with, be located the loop bar 42 that spring bar 41 outer end slided and set up, be located the terminal fixed spacing cap 43 that sets up of loop bar 42, the upper surface of spacing cap 43 is the arc setting, the both sides face of spacing cap 43 is the plane setting, the middle part of every group loop through a set of connecting rod 44 and connect into a whole, brush board 3 is equipped with the second push pedal 36 that runs through the cylinder 1 side with spacing 4 corresponding position department, second push pedal 36 extends to and is used for promoting in the circular slot 16 spacing cap 43 and makes every group loop bar 42 synchronous along the inboard slip of spring bar 41.
As shown in fig. 3, the limiting block 31, the magnetic attraction plate 32, the first push plate 34, the sensing push rod 35, and the second push plate 36 are all connected to the drum 1 in a sealing and sliding manner.
The method for sampling the conjunctival cells of the person to be sampled by using the conjunctival cell brush comprises the following steps of:
the working principle of this embodiment is basically the same as that of embodiment 1, and the difference is that:
open connecting axle 2 through folding when using, through the length of flexible regulation connecting axle 2, folding packing up connecting axle 2 after using simultaneously, it is more convenient to make conjunctiva cell brush carry, can extend connecting axle 2 simultaneously and make cylinder 1 and brush board 3 go deep into the cell preservation liquid that collects in the test tube and collect when the cell sample of reacing.
Example 4
The embodiment is basically the same as the embodiment 1, except that 3 groups of brush plates 3 are integrally arranged, and a sterile film for wrapping the handle 5 and the connecting shaft 2 is arranged at the position of the brush plates 3 close to the handle 5, so as to prevent the brush plates 3 from being polluted by bacteria;
when using, it is more convenient that integral brush board is changed, when in the cell transfer to the collection test tube on with brush board 3, the outer bottom of collecting the test tube adds and establishes ultrasonic device and make the cell sample on brush board 3 evenly drop to in collecting the test tube under ultrasonic vibration's condition and can not lead to the fact the damage to the conjunctiva cell, set up the vibrator simultaneously in 1 inside cylinders, it is the cell-phone vibrator of selling, add an eccentric wheel including a miniature ordinary motor, be used for shaking the cell when the transfer is deposited and drop, can realize breaking away from the cell from the brush board fast.
Claims (9)
1. The conjunctiva cell brush convenient to adjust and used for eye conjunctiva cell sampling is characterized by comprising a roller (1) and a connecting shaft (2), wherein two end faces of the roller (1) are regular triangles, each side face of the roller (1) is rectangular in the same size, each side face of the roller (1) is provided with a group of movable brush plates (3), the size of each brush plate (3) is the same as that of the side face of the roller (1), the front end of the connecting shaft (2) penetrates through the center of one end face of the roller (1) and is rotatably connected with the roller (1), and the inside of the roller (1) is hollow;
the brush plate (3) bottom center is provided with a limit block (31) used for preventing the brush plate (3) from separating from the roller (1) near one end of the connecting shaft (2), the limit block (31) penetrates through the side surface of the roller (1) and extends into the roller (1), the center of the bottom of the brush plate (3) on one side of the limit block (31) is provided with a magnetic suction plate (32) used for fixing the brush plate (3) and the roller (1) with the connecting shaft (2), the connecting shaft (2) is provided with a circle of magnetic suction part (21) corresponding to the magnetic suction plate (32) and used for mutually attracting and laminating with the magnetic suction plate (32), the end surface of the magnetic suction plate (32) is arc-shaped, two anti-slip parts (33) are arranged on two sides of the end surface of the magnetic suction plate (32), two groups of reset plates (11) are arranged on the center of the inner side surface of the roller (1) on one side of the magnetic suction plate (32), and each group of reset plates (11) is connected with the inner side surface of the roller (1) through a spring (12), a first push plate (34) penetrating through the side face of the roller (1) is arranged at the position, corresponding to the reset plate (11), of the brush plate (3), a heating plate (13) is arranged at the center of the inner side face of the roller (1) positioned between the two reset plates (11), an inductor (14) is arranged on one side of the heating plate (13), and an induction push rod (35) used for triggering the inductor (14) to be switched after movement is arranged at the position, corresponding to the inductor (14), of the brush plate (3);
a limiting part (4) used for limiting the transverse sliding between the connecting shaft (2) and the roller (1) is arranged at the position, close to the foremost end, of the connecting shaft (2), and a movable groove (15) used for being movably matched and connected with the tail end of the connecting shaft (2) is arranged in the roller (1) corresponding to the limiting part (4);
the outer surface of the brush plate (3) is provided with brush hair.
2. The conjunctival cell brush for ocular conjunctival cell sampling convenient to adjust according to claim 1, wherein the connecting shaft (2) is provided with a handle (5) at the end, and the handle (5) is detachably arranged with the connecting shaft (2).
3. The conjunctival cell brush convenient to adjust for sampling the conjunctival cells of the eyes according to claim 1, wherein the spring (12) drives the reset plate (11) to push the first push plate (34) away from the inner side surface of the roller (1), and the limit block (31) is attached to the inner side surface of the roller (1).
4. The conjunctival cell brush for ocular conjunctival cell sampling convenient to adjust according to claim 1, wherein the surface of the anti-slip part (33) is provided with anti-slip stripes, and the anti-slip stripes are arranged in a plurality of transverse wave lines.
5. The conjunctival cell brush for ocular conjunctival cell sampling convenient for adjustment according to claim 1, wherein the springs (12) are in two groups and are respectively located on both sides of the first push plate (34).
6. The conjunctiva cell brush convenient to adjust for sampling the conjunctiva cells of the eyes according to claim 1, wherein the diameter of the connecting shaft (2) where the limiting part (4) is located is smaller than the diameter of the connecting shaft (2) of other parts, the limiting part (4) is arranged in an annular groove (22) at the front end of the connecting shaft (2), a circular groove (16) is arranged in the roller (1) corresponding to the annular groove (22), the limiting part (4) comprises a plurality of spring rods (41) arranged in the circumferential direction, a loop rod (42) arranged at the outer end of the spring rod (41) in a sliding manner, a limiting cap (43) fixedly arranged at the tail end of the loop rod (42), the middle part of each loop rod (42) is connected into a whole through a group of connecting rods (44) in sequence, a second push plate (36) penetrating through the side surface of the roller (1) is arranged at the position of the brush plate (3) corresponding to the limiting part (4), the second push plate (36) extends into the circular groove (16) and is used for pushing the limiting cap (43) to enable each group of loop bars (42) to synchronously slide inwards along the spring rod (41).
7. The conjunctival cell brush convenient to adjust for sampling of conjunctival cells of eyes according to claim 6, wherein the limiting block (31), the magnetic attraction plate (32), the first push plate (34), the induction push rod (35) and the second push plate (36) are all connected with the roller (1) in a sealing and sliding manner.
8. The conjunctival cell brush for ocular conjunctival cell sampling convenient for adjustment according to claim 6, wherein the upper surface of the limiting cap (43) is arc-shaped, and two side surfaces of the limiting cap (43) are plane.
9. A conjunctival cell brush for ocular conjunctival cell sampling convenient to adjust according to claim 1, wherein the bristles are made of silica gel or cotton.
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| CN202110801183.7A CN113576550B (en) | 2021-07-15 | 2021-07-15 | Conjunctival cell brush convenient to adjust and used for eye conjunctival cell sampling |
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| CN202110801183.7A CN113576550B (en) | 2021-07-15 | 2021-07-15 | Conjunctival cell brush convenient to adjust and used for eye conjunctival cell sampling |
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| CN113576550B CN113576550B (en) | 2024-02-20 |
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| CN215534629U (en) * | 2021-07-15 | 2022-01-18 | 温州医科大学附属眼视光医院 | Conjunctival cell brush for sampling conjunctival cells of eyes |
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| US5649943A (en) * | 1994-06-15 | 1997-07-22 | Amoils; Percy | Ophthalmic treatment apparatus and its use |
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| CN113576550B (en) | 2024-02-20 |
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