CN113575969A - Medical formula food containing tryptophan and used for relieving epilepsy and preparation method thereof - Google Patents

Medical formula food containing tryptophan and used for relieving epilepsy and preparation method thereof Download PDF

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Publication number
CN113575969A
CN113575969A CN202110861813.XA CN202110861813A CN113575969A CN 113575969 A CN113575969 A CN 113575969A CN 202110861813 A CN202110861813 A CN 202110861813A CN 113575969 A CN113575969 A CN 113575969A
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tryptophan
epilepsy
oil
formula food
relieving
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王元秀
李旭
丁良
蔡胜峰
张明
刘娟
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Dong'a Chenkang Pharmaceutical Co ltd
University of Jinan
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Dong'a Chenkang Pharmaceutical Co ltd
University of Jinan
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Publication of CN113575969A publication Critical patent/CN113575969A/en
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Polymers & Plastics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

The invention provides a medical formula food containing tryptophan and used for relieving epilepsy and a preparation method thereof, wherein each 100 g of the medical formula food containing tryptophan and used for relieving epilepsy contains: 20-40 g of protein, 40-80 g of grease powder, 10-30 g of carbohydrate, 0.005-0.02 g of GABA, 0.01-0.5 g of tryptophan, 3-8 g of mineral premix and 0.05-0.15 g of vitamin premix, and all the components are uniformly mixed to obtain the finished product. The invention utilizes GABA to increase GABA content in brain, maintain balance between excitatory neurotransmitter and inhibitory neurotransmitter in brain, relieve oxidative stress caused by metabolism of amino acid in body and prolong epileptic seizure period of patient by synergistic effect of various components.

Description

Medical formula food containing tryptophan and used for relieving epilepsy and preparation method thereof
Technical Field
The invention relates to a nutritional preparation, in particular to a medical formula food containing tryptophan and used for relieving epilepsy and a preparation method thereof, and belongs to the technical field of biology.
Background
Epilepsy is a chronic neurological disorder. At present, more than 600 million epileptics in China exist, and 65-70 million new epileptics are used every year. The onset of epilepsy is caused by an imbalance between central nervous system excitation and inhibition, which is mainly associated with changes in ion channels, neurotransmitters and glial cells. The gene mutation can cause the ion channel dysfunction, namely the defective gene codes defective ion channel protein to cause diseases, wherein the research on the correlation of sodium ion, potassium ion and calcium ion channels and epilepsy is more clear; when excitatory neurotransmitter is too much or inhibitory neurotransmitter is too little, imbalance between excitation and inhibition can be caused, neurons are over-discharged, and epilepsy is caused; seizures can result when astrocytes have altered uptake of glutamate (Glu) or gamma-aminobutyric acid (GABA). The inhibitory neurotransmitters important in the central nervous system are GABA and glycine, and the excitatory neurotransmitters include Glu and aspartic acid.
The first suggestion that epileptogenesis is related to intracerebral GABA was that Tower (Mckhann G M, Tower D B. gamma-amino acids: a substrate for oxidative metabolism of cerebral core [ J ]. The American journel of physiology, 1959, 196(1): 36-38.) shows that The GABA content in brain tissue of experimental convulsive animals-cats is significantly reduced.
In 2009, Fretias et al (Fretias R M D, Nasciento K G D, Ferreira P, et al, Neurochemical change on oxidative stress in a thioppocampus duringphase of pirocarpine-induced epilepsy [ J ]. Pharmacology Biochemistry and Behavior 2010, 94: 341-345.) demonstrated by rat experiments that oxidative stress plays an important role in the onset of epilepsy and that the duration of epilepsy was positively correlated with oxidative damage.
Tryptophan can relieve oxidative stress (NAYAK B N, BUTTAR H S. Evaluation of the antioxidant properties of tryptophans and its metabolites in the vitamin assay [ J ]. Journal of Complementary and integral Medicine, 2016, 13: 129-136.), the oxidative stress can enhance the catabolism of tryptophan, the amino group of tryptophan can be directly combined with an oxidizing agent, the oxidation reaction of other substances can be effectively prevented, and the antioxidant effect can be achieved. Melatonin, a metabolite of tryptophan, acts as a non-enzymatic antioxidant to scavenge free radicals in the body and also has antioxidant activity.
Tryptophan produces 5-hydroxytryptamine in vivo by catalysis by tryptophan hydroxylase and aromatic acid decarboxylase, 5-hydroxytryptamine being the most widely affected in epilepsy (Xu W, Orr-Urterrer A, Nigro F, et al]J Neurosci, 1999, 19(21): 9298-9305.), 5-hydroxytryptamine bind to the 5-HT3 receptor by altering Na+、K+And Ca2+The permeability of (A) causes depolarization of neurons and inhibits seizures (ZHao H, Lin Y, Chen S, et al. 5-HT3 receptors: a potential therapeutic target for epilepsy [ J)]Curr Neuropharmacol, 2018, 16(1): 29-36.). Tryptophan has the effects of eliminating free radicals and resisting oxidation, and can relieve oxidative stress, thereby relieving epilepsy; meanwhile, tryptophan can be metabolized in vivo to generate 5-hydroxytryptamine, so that epileptic seizure is inhibited, and based on the principle, the medical formula food containing tryptophan and used for relieving epilepsia and the preparation method thereof are prepared.
Disclosure of Invention
The invention provides a medical formula food containing tryptophan and used for relieving epilepsy and a preparation method thereof, and aims to prolong the epileptic seizure period of a patient by utilizing the influence of metabolism of amino acid in a body on oxidative stress.
Formula food compound with special medical application
The medical formula food containing tryptophan for relieving epilepsy contains the following components in every 100 g:
20-40 g of protein, namely the protein,
40-80 g of grease powder,
10-30 g of carbohydrate, wherein the carbohydrate is a natural carbohydrate,
GABA 0.005-0.02 g，
0.01-0.5 g of tryptophan,
3-8 g of mineral premix, and the like,
0.05-0.15 g of vitamin premix.
The protein is one or a mixture of more of concentrated whey protein, hydrolyzed whey protein, soy protein isolate and sodium caseinate.
The oil powder is prepared from 40-50 wt% of oil and 40-50 wt% of edible carrier by mixing oil and edible carrier, and spray drying to obtain powder.
The oil is one or more of soybean oil, peanut oil, linseed oil, perilla seed oil and medium chain triglyceride.
The carbohydrate is one or a mixture of more of maltodextrin, fructo-oligosaccharide and inulin.
Each gram of the mineral premix comprises 30-80 mg of calcium carbonate, 15-20 mg of magnesium chloride, 50-100 mg of edible salt, 80-150 mg of potassium chloride, 20-60 mg of monopotassium phosphate, 0.5-1.0 mg of ferrous sulfate monohydrate, 0.2-0.6 mg of zinc sulfate monohydrate, 0.001-0.01 mg of sodium selenite, 0.03-0.06 mg of anhydrous copper sulfate, 0.01-0.05 mg of manganese citrate, 0.005-0.01 mg of potassium iodide and the balance of mineral premix carrier.
The mineral premix carrier is maltodextrin.
Each gram of the vitamin premix comprises 2-5 mg of vitamin A, 0.03-0.06 mg of vitamin D, 500 mg of ascorbic acid 250-one, 30-60 mg of vitamin E, 10.1-0.5 mg of vitamin K, 3-6 mg of thiamine, 2-6 mg of riboflavin, 8-15 mg of nicotinamide, 15-20 mg of pantothenic acid, 3-6 mg of pyridoxine hydrochloride, 0.5-2.5 mg of folic acid, 0. 120.003-0.020 mg of vitamin B, 0.05-0.25 mg of biotin and the balance of vitamin premix carrier.
The vitamin premix carrier is maltodextrin.
② mixing the formula food with special medical application
Crushing the weighed nutrients, sieving with a 100-mesh sieve, and mixing and uniformly mixing by using a mixer.
The medical formula food provided by the invention has the effects of prolonging the seizure time of epilepsy, reducing the oxidative stress in bodies of epileptics and relieving epilepsy.
The medical formula food can be granules or granules, and can also be prepared into liquid forms such as beverages and the like.
The medical formula food provided by the invention contains proteins such as soybean protein isolate, concentrated whey protein, sodium caseinate and the like, has rich nitrogen sources, better supplements the required proteins, is rich in unsaturated fatty acids such as medium-chain fatty acid and DHA, and has an important inhibiting effect on oxidative stress of epileptics.
According to the medical formula food provided by the invention, GABA and tryptophan are particularly added, the GABA can increase the GABA content in the brain, the balance between excitatory neurotransmitter and inhibitory neurotransmitter in the brain is maintained, and the tryptophan has the effects of reducing and eliminating free radicals, resisting oxidation and the like, relieving oxidative stress and achieving the effect of relieving epilepsy.
The medical formula food provided by the invention adopts maltodextrin and other low GI carbohydrates, and is beneficial to the control of blood sugar of patients.
The medical formula food provided by the invention is a composite food, combines proteins such as soybean protein isolate, concentrated whey protein and the like, supplements required proteins, combines tryptophan to relieve the oxidative stress of epileptics, combines maltodextrin and other carbohydrates with low GI (glucose) to control the blood sugar of patients, relieves the oxidative stress of epileptics through the synergistic effect of various components, improves the immunity of patients, and relieves the morbidity of epileptics. The medical formula food can be used as a nutritional food for providing nutritional support for intractable epileptics, and can also be used as a nutritional support for common epileptics.
Example 1:
formula food compound with special medical application
The medical formula food containing tryptophan for relieving epilepsy contains the following components in every 100 g:
28.77 g of the isolated soy protein,
46.92 g of a medium chain triglyceride powder,
18.15 g of maltodextrin, 18.15 g,
GABA 0.01 g，
0.18 g of tryptophan was added thereto,
5.87 g of mineral premix, namely,
0.10 g of vitamin premix.
The medium chain triglyceride powder is prepared by mixing medium chain triglyceride and maltodextrin at a weight ratio of 1:1, and spray drying to obtain powder.
1g of mineral premix comprises 56 mg of calcium carbonate, 18.3 mg of magnesium chloride, 83 mg of edible salt, 111 mg of potassium chloride, 40 mg of monopotassium phosphate, 0.83 mg of ferrous sulfate monohydrate, 0.4 mg of zinc sulfate monohydrate, 0.003 mg of sodium selenite, 0.044 mg of anhydrous copper sulfate, 0.025 mg of manganese citrate, 0.007 mg of potassium iodide and the balance of maltodextrin.
The vitamin premix 1g comprises 3.6 mg of vitamin A, 0.048 mg of vitamin D, 336 mg of ascorbic acid, 48 mg of vitamin E, 10.264 mg of vitamin K, 4.2 mg of thiamine, 4.2 mg of riboflavin, 12 mg of nicotinamide, 17.4 mg of pantothenic acid, 4.2 mg of pyridoxine hydrochloride, 1.332 mg of folic acid, 120.0078 mg of vitamin B, 0.132 mg of biotin and the balance of maltodextrin.
② mixing the formula food with special medical application
Crushing the weighed nutrients, sieving with a 100-mesh sieve, and mixing and uniformly mixing by using a mixer.
Example 2:
formula food compound with special medical application
The medical formula food containing tryptophan for relieving epilepsy contains the following components in every 100 g:
28.77 g of concentrated whey protein is obtained,
62.56 g of the oil-and-fat powder,
11.28 g of fructo-oligosaccharide,
GABA 0.03 g，
0.05 g of tryptophan,
6.03 g of mineral premix, namely,
0.05 g of vitamin premix.
The oil powder is prepared from oil and maltodextrin at a weight ratio of 1:1 by mixing oil and maltodextrin, and spray drying to obtain powder.
The oil is prepared by mixing perilla seed oil and medium chain triglyceride.
1g of mineral premix comprises 56 mg of calcium carbonate, 18.3 mg of magnesium chloride, 83 mg of edible salt, 111 mg of potassium chloride, 40 mg of monopotassium phosphate, 0.83 mg of ferrous sulfate monohydrate, 0.4 mg of zinc sulfate monohydrate, 0.003 mg of sodium selenite, 0.044 mg of anhydrous copper sulfate, 0.025 mg of manganese citrate, 0.007 mg of potassium iodide and the balance of maltodextrin.
The vitamin premix 1g comprises 3.6 mg of vitamin A, 0.048 mg of vitamin D, 336 mg of ascorbic acid, 48 mg of vitamin E, 10.264 mg of vitamin K, 4.2 mg of thiamine, 4.2 mg of riboflavin, 12 mg of nicotinamide, 17.4 mg of pantothenic acid, 4.2 mg of pyridoxine hydrochloride, 1.332 mg of folic acid, 120.0078 mg of vitamin B, 0.132 mg of biotin and the balance of maltodextrin.
② mixing the formula food with special medical application
Crushing the weighed nutrients, sieving with a 100-mesh sieve, and mixing and uniformly mixing by using a mixer.
Example 3:
formula food compound with special medical application
The medical formula food containing tryptophan for relieving epilepsy contains the following components in every 100 g:
35 g of sodium caseinate, namely 35 g,
the weight of the linseed oil powder is 40 g,
20 g of inulin and a preparation method thereof,
GABA 0.05 g，
0.5 g of tryptophan is added in the mixture,
4.3 g of mineral premix, namely,
0.15 g of vitamin premix.
The linseed oil powder consists of linseed oil and maltodextrin in a weight ratio of 1:1, and is prepared by mixing the linseed oil and the maltodextrin, and performing spray drying on the mixture to prepare powder.
1g of mineral premix comprises 56 mg of calcium carbonate, 18.3 mg of magnesium chloride, 83 mg of edible salt, 111 mg of potassium chloride, 40 mg of monopotassium phosphate, 0.83 mg of ferrous sulfate monohydrate, 0.4 mg of zinc sulfate monohydrate, 0.003 mg of sodium selenite, 0.044 mg of anhydrous copper sulfate, 0.025 mg of manganese citrate, 0.007 mg of potassium iodide and the balance of maltodextrin.
The vitamin premix 1g comprises 3.6 mg of vitamin A, 0.048 mg of vitamin D, 336 mg of ascorbic acid, 48 mg of vitamin E, 10.264 mg of vitamin K, 4.2 mg of thiamine, 4.2 mg of riboflavin, 12 mg of nicotinamide, 17.4 mg of pantothenic acid, 4.2 mg of pyridoxine hydrochloride, 1.332 mg of folic acid, 120.0078 mg of vitamin B, 0.132 mg of biotin and the balance of maltodextrin.
② mixing the formula food with special medical application
Crushing the weighed nutrients, sieving with a 100-mesh sieve, and mixing and uniformly mixing by using a mixer.
The invention provides the influence of the formula food for the special medical application of the epileptic patient on the epileptic attack of the mice:
constructing an epilepsia mouse model, taking the test of the example 1-3, only irrigating the stomach, setting a negative control group at the same time, irrigating the stomach with physiological saline of the negative control group, and normally feeding. Kunming mice, male, weight 18-22 g, each group of 10. Mice were gavaged daily for 7 consecutive days at a dose of 0.05 g/10 g. Weighing 1 time every day, observing the disease condition, taking blood from eyeball after last gastric lavage for 1 h, and detecting malondialdehyde content and enzyme activities of superoxide dismutase, glutathione peroxidase and SOD with malondialdehyde detection kit (Nanjing institute of bioengineering), superoxide dismutase detection kit (Nanjing institute of bioengineering), glutathione peroxidase detection kit (Nanjing institute of bioengineering), and SOD commercial detection kit (Biyuntian). The results of the influence of the formula food for special medical application of epileptics on the body weight of a mouse are shown in table 1, the results of the influence on the attack of epilepsy are shown in table 2, and the influences on the malonaldehyde content and the enzyme activity are shown in table 3.
TABLE 1 Effect of formula foods for specific medical uses on body weight of mice in epileptic patients
Initial body weight (g) Heavy body weight (g) Weight gain (g)
Example 1 23.67 29.07 5.40
Example 2 23.70 28.20 4.50
Example 3 23.66 28.72 5.06
Negative control group 23.64 28.47 4.83
As can be seen from Table 1, there was no significant difference in the weight gain (P > 0.05) in the mice of examples 1-3, compared to the negative control group. Therefore, the preparation has no obvious influence on the weight increase of mice, and can maintain the normal physiological function of the mice.
TABLE 2 influence of formula food for special medical use of epileptic on onset of epilepsy in mice
Prolonged attack time compared to negative control group
Example 1 40 s
Example 2 30 s
Example 3 35 s
As can be seen from Table 2, the formula food for the special medical use of the epileptic provided by the invention can obviously prolong the epileptic seizure period of mice and is beneficial to relieving epilepsy.
TABLE 3 influence of formula food for special medical use on blood index of mouse for epileptic
GSH-Px（μmol/L） CAT（U/g） SOD（U/mL） MDA（nmol/mL）
Example 1 32.46±2.68 93.71±10.48 19.34±2.43 40.63±7.25
Example 2 25.55±2.24 90.08±20.91 18.62±2.77 44.41±6.53
Example 3 21.51±2.67 87.42±21.47 18.14±1.79 55.35±6.40
Negative control group 18.89±2.95 85.00±14.14 15.23±2.01 60.05±7.02
As can be seen from Table 3, the formula food for the special medical application of the epileptic provided by the invention can improve the enzyme activities of superoxide dismutase, glutathione peroxidase and SOD and reduce the content of malondialdehyde relative to a negative control group, and can relieve the epilepsy of mice.

Claims (8)

1. Formula food compound with special medical application
The medical formula food containing tryptophan for relieving epilepsy contains the following components in every 100 g:
20-40 g of protein, namely the protein,
40-80 g of grease powder,
10-30 g of carbohydrate, wherein the carbohydrate is a natural carbohydrate,
GABA 0.005-0.02 g，
0.01-0.5 g of tryptophan,
3-8 g of mineral premix, and the like,
0.05-0.15 g of vitamin premix;
② mixing the formula food with special medical application
Crushing the weighed nutrients, sieving with a 100-mesh sieve, and mixing and uniformly mixing by using a mixer.
2. The medical formula containing tryptophan for relieving epilepsy as claimed in claim 1, wherein the protein is one or more of concentrated whey protein, hydrolyzed whey protein, soy protein isolate and sodium caseinate.
3. The tryptophan-containing medical formula food for relieving epilepsy as claimed in claim 1, wherein the oil powder is prepared from oil and edible carrier at a weight ratio of (40-50) to (40-50), by mixing the oil and edible carrier, and spray drying to obtain powder.
4. The tryptophan-containing medical formula for relieving epilepsy as claimed in claim 1, wherein the oil is one or more of soybean oil, peanut oil, linseed oil, perilla seed oil and medium chain triglyceride.
5. The tryptophan-containing medical formula for relieving epilepsy as claimed in claim 1, wherein the carbohydrate is one or more of maltodextrin, fructo-oligosaccharide and inulin.
6. The tryptophan-containing medical formula for relieving epilepsy as claimed in claim 1, wherein each 1g of the mineral premix comprises 30-80 mg of calcium carbonate, 15-20 mg of magnesium chloride, 50-100 mg of edible salt, 80-150 mg of potassium chloride, 20-60 mg of monopotassium phosphate, 0.5-1.0 mg of ferrous sulfate monohydrate, 0.2-0.6 mg of zinc sulfate monohydrate, 0.001-0.01 mg of sodium selenite, 0.03-0.06 mg of anhydrous copper sulfate, 0.01-0.05 mg of manganese citrate, 0.005-0.01 mg of potassium iodide, and the balance of mineral premix carrier.
7. The tryptophan-containing medical formula food for relieving epilepsy as claimed in claim 1, wherein each 1g of the mineral premix comprises 50-60 mg of calcium carbonate, 18-19 mg of magnesium chloride, 80-90 mg of edible salt, 100 mg of potassium chloride, 30-50 mg of monopotassium phosphate, 0.8-0.9 mg of ferrous sulfate monohydrate, 0.3-0.5 mg of zinc sulfate monohydrate, 0.002-0.004 mg of sodium selenite, 0.04-0.05 mg of anhydrous copper sulfate, 0.02-0.03 mg of manganese citrate, 0.006-0.008 mg of potassium iodide, and the balance of mineral premix carrier.
8. The tryptophan-containing medical formula for use in relieving epilepsy as claimed in claims 6 to 7, wherein the premix carrier is maltodextrin.
CN202110861813.XA 2021-07-29 2021-07-29 Medical formula food containing tryptophan and used for relieving epilepsy and preparation method thereof Withdrawn CN113575969A (en)

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