CN113567597B - Acute cerebral infarction prevention early warning equipment and application method thereof - Google Patents

Acute cerebral infarction prevention early warning equipment and application method thereof Download PDF

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CN113567597B
CN113567597B CN202110798418.1A CN202110798418A CN113567597B CN 113567597 B CN113567597 B CN 113567597B CN 202110798418 A CN202110798418 A CN 202110798418A CN 113567597 B CN113567597 B CN 113567597B
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early warning
side wall
blood
cerebral infarction
prevention
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CN113567597A (en
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刘南海
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First Affiliated Hospital of Gannan Medical University
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First Affiliated Hospital of Gannan Medical University
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/04Preparation or injection of sample to be analysed
    • G01N30/06Preparation
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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Abstract

The application discloses acute cerebral infarction prevention and early warning equipment and a use method thereof, and relates to the technical field of cerebral infarction prevention and early warning equipment. According to the acute cerebral infarction prevention early warning device and the application method thereof, the prevention early warning trigger assembly is arranged, so that the blood centrifugation layering assembly can effectively separate blood plasma containing lysophosphatidic acid, the high performance liquid chromatography analysis assembly separates the lysophosphatidic acid in the blood plasma, the control degree warning unit carries out warning prompt on a detection result, a patient can know the disease degree of the acute cerebral infarction in time, a person with the disease can know the disease degree and treat the disease in a period of time better, the prevention early warning device has stronger practicability and better prevention early warning effect.

Description

Acute cerebral infarction prevention early warning equipment and application method thereof
Technical Field
The application relates to the technical field of cerebral infarction prevention and early warning equipment, in particular to acute cerebral infarction prevention and early warning equipment and a using method thereof.
Background
Acute cerebral infarction refers to brain tissue necrosis caused by sudden interruption of cerebral blood supply, and is usually caused by atherosclerosis and thrombosis mainly caused by arterial thrombosis of supplying cerebral blood, lumen stenosis and even occlusion, which cause ischemic necrosis of focal acute brain cells, and softening and necrosis of brain tissue of corresponding dominant region caused by blood flow interruption or blood flow rapid reduction caused by arterial embolism entering cerebral artery or neck artery supplying cerebral blood circulation, and the illness state of acute cerebral infarction can be known by detecting the lysophosphatidic acid content in blood.
At present, the incidence rate of acute cerebral infarction is higher, and patients cannot know the incidence degree of the acute cerebral infarction in time, so that the acute cerebral infarction cannot be effectively prevented and early-warned, and the incidence degree of the patients after the incidence is further worsened or gradually improved and is not easy to judge, so that the application provides the acute cerebral infarction prevention and early-warning equipment and the use method thereof to meet the demands.
Disclosure of Invention
The application aims to provide an acute cerebral infarction prevention early warning device and a use method thereof, so as to solve the problems in the background technology.
In order to achieve the above purpose, the present application provides the following technical solutions: the utility model provides an acute cerebral infarction prevention early warning equipment, includes the detection frame, install in the supporting base of detection frame bottom, install on the lateral wall of detection frame and be used for carrying out centrifugal blood centrifugation layering subassembly to collection blood, install on the detection frame and be used for to the high performance liquid chromatography analysis subassembly that carries out extraction processing to the blood plasma after separation of blood centrifugation layering subassembly, install on the high performance liquid chromatography analysis subassembly and be used for carrying out the prevention early warning trigger subassembly of suggestion to the testing result, install on the detection frame and be used for sending the degree warning unit of warning, prevention early warning trigger subassembly with degree warning unit looks adaptation is installed; the degree warning unit is used for giving alarms of different degrees to the detection result.
By means of the structure, through the prevention early warning trigger assembly, the blood centrifugation layering assembly can effectively separate blood plasma containing lysophosphatidic acid, the high performance liquid chromatography analysis assembly separates the lysophosphatidic acid in the blood plasma, the control degree warning unit carries out warning prompt on a detection result, a patient can know the incidence degree of acute cerebral infarction of the patient in time, a person with the illness state can better know the illness state degree in a period of time and treat the illness state, the prevention early warning equipment is higher in practicality, and the prevention early warning effect is better.
Preferably, the blood centrifugation layering subassembly including install in fixed curb plate on the detection frame lateral wall, centrifugal motor is installed to the bottom of fixed curb plate, the rotation hole has been seted up at the top of fixed curb plate, centrifugal motor's output run through in the rotation hole, centrifugal disk is installed to centrifugal motor's output, a plurality of fixed stop that evenly set up are installed at centrifugal disk's top, a plurality of all install telescopic spring on fixed stop's the lateral wall, a plurality of movable splint are all installed to telescopic spring's one end, a plurality of clamping groove has all been seted up on movable splint's the lateral wall.
Further, through blood centrifugation layering subassembly, place the blood sample test tube of gathering between four movable clamp plates, under the elastic deformation restoring force effect of extension spring, make the test tube can be stable fix in a plurality of clamping grooves, start centrifugal motor, make centrifugal disk take place to rotate, make the test tube take place stable rotation, make blood divide into blood cell layer and plasma layer, make the plasma layer that contains lysophosphatidic acid be located the test tube top, make the prevention early warning equipment more stable quick carry out detection analysis to the lysophosphatidic acid content in the blood, the testing result that the prevention early warning equipment obtained is more accurate, make the prevention early warning equipment can be better detect the early warning to acute cerebral infarction state of illness.
Preferably, the high performance liquid chromatography subassembly including install in the L shape mounting panel at detection frame top, install in detector on the inner wall of detection frame bottom, install in the mounting bracket on the detection frame lateral wall, install at the top of detector prevent early warning trigger subassembly, hydraulic telescoping cylinder is installed to the bottom of L shape mounting panel, the output of hydraulic telescoping cylinder install the pressurization pump body, L shape connecting rod, the drawing liquid pipe is installed to the water inlet end of the pressurization pump body, the feed liquor pipe is installed to the water outlet end of the pressurization pump body, the extrusion stopper is installed to the one end of L shape connecting rod, hold a section of thick bamboo is installed at the top of mounting bracket, the extrusion stopper adaptation install in hold on the inner wall of section of thick bamboo, hold and seted up the apopore on the lateral wall of section of thick bamboo, install communicating pipe on the inner wall of apopore, set up the inlet opening on the lateral wall of feed liquor pipe, the one end of communicating pipe install in on the inner wall of inlet opening, the chromatographic column is installed to the one end of feed liquor pipe, the chromatographic column is installed to the bottom of chromatographic column, the connecting column is installed to the end of connecting pipe.
Further, through high performance liquid chromatography analysis subassembly, make the flexible jar of hydraulic pressure start, drive the pressurization pump body and take place simultaneously with L shape connecting rod and remove, the position that makes the drawing liquid pipe insert test tube plasma layer and the extrusion stopper insert hold the position in the section of thick bamboo more unified, the lysophosphatidic acid in the messenger plasma separates out through the chromatographic column, the lysophosphatidic acid that makes the separation out gets into in the detector and carries out analysis and detection, the messenger prevents early warning equipment and can be more accurate carries out the early warning suggestion to acute cerebral infarction state of illness, the messenger prevents that early warning equipment is more stable when using, the degree of accuracy is higher.
Preferably, a graduated scale is arranged on the side wall of the L-shaped mounting plate, a moving hole is formed in the side wall of the L-shaped mounting plate, the liquid inlet guide pipe is adapted to be arranged on the inner wall of the moving hole, and a mixed solution of potassium dihydrogen phosphate and tetrabutylammonium hydroxide is arranged in the holding cylinder.
Furthermore, the amount of the plasma and the mixed solution is controlled through the graduated scale, so that the pre-warning equipment can conveniently detect and analyze the content of the lysophosphatidic acid.
Preferably, the prevention early warning trigger assembly is including installing in the fixed stand at detector top, data analysis appearance is installed on the top of fixed stand, install two fixed squares on data analysis appearance's the lateral wall, two rotate on the lateral wall of fixed square and install the connection lead screw, the movable slider has been cup jointed on the connection lead screw, install the side cardboard on the lateral wall of movable slider, install identification probe on the lateral wall of side cardboard, the trigger is installed to the bottom of movable slider, the trigger with degree warning unit looks adaptation is installed.
Further, the data analyzer obtains and displays the detection result through the prevention early warning trigger assembly, the identification probe detects the result displayed on the data analyzer, and the prevention early warning device sends out early warning prompt through the contact position of the trigger and the degree warning unit, so that people can know the acute cerebral infarction condition of the people conveniently.
Preferably, an adjusting motor is mounted on the side wall of one of the fixed blocks, the output end of the adjusting motor is provided with the connecting screw rod, and the side wall of the movable sliding block is in contact with the side wall of the data analyzer.
Further, when the connecting screw rod rotates through the movable sliding block, the movable sliding block can be driven to move more stably, so that the preventive early warning equipment is more stable in use.
Preferably, the degree warning unit comprises a fixed cross beam arranged on the inner wall of the detection frame, two mounting clamping seats are arranged on the fixed cross beam, a first warning unit for warning a single detection result and a second warning unit for comparing and warning detection results on two sides are arranged on the mounting clamping seats, a receiver is arranged on the side wall of the fixed cross beam, and the receiver is arranged in a matched mode with the trigger.
Further, through the degree warning unit, people can know the disease degree of the acute cerebral infarction in time, people with disease states can better know the disease states in a period of time and treat the disease states, and the preventive early warning device is higher in practicality and better in preventive early warning effect.
Preferably, the first alarm unit comprises a plurality of indicator lamps which are arranged at the top of the installation clamping seat in a vertical connection mode, and an alarm is arranged on the side wall of the indicator lamp at the upper part.
Further, through first alarm unit, make personnel in time know self acute cerebral infarction incidence degree, make prevention early warning equipment practicality stronger, the prevention early warning effect is better.
Preferably, the second alarm unit comprises a plurality of indicator lamps which are vertically connected and arranged and are respectively arranged at the tops of the two mounting clamping seats, and two alarms are correspondingly arranged on the side walls of the indicator lamps positioned above the indicator lamps.
Further, through the second alarm unit, people who have the state of an illness can better know the state of an illness in a period of time and treat, make prevention early warning equipment practicality stronger, prevention early warning effect is better.
The application also discloses a use method of the acute cerebral infarction prevention early warning device, which is characterized by comprising the following steps:
s1, blood collection and separation: placing the collected blood sample test tube between four movable clamping plates, starting a centrifugal motor to enable the test tube to rotate, and separating blood into a plasma layer containing lysophosphatidic acid and a blood cell layer not containing the lysophosphatidic acid;
s2, analyzing and detecting the content of lysophosphatidic acid: starting a hydraulic telescopic cylinder to enable a pressurizing pump body to drive a liquid suction pipe to move downwards and insert into a test tube, enabling the liquid suction pipe to be placed in a plasma layer, simultaneously starting the pressurizing pump body to enable a certain amount of plasma to enter a liquid inlet conduit, enabling a mixed solution of potassium dihydrogen phosphate and tetrabutylammonium hydroxide in a containing cylinder to enter the liquid inlet conduit at the same time, enabling the plasma and the mixed solution to enter a chromatographic column at the same time, further enabling lysophosphatidic acid to be separated out, and further entering a detector, and enabling the detector to analyze and detect the content of the lysophosphatidic acid;
s3, alarming the degree of the detection result: the detection result is obtained through the data analyzer, the detection is carried out on the result displayed on the data analyzer through the identification probe, the adjusting motor is started, the movable sliding block drives the trigger to move, the quantity of the indication lamps which are turned on is changed through the contact positions between the trigger and the receiver, the alarm indicates that the risk of the acute cerebral infarction is higher when the alarm sounds, and the alarm does not sound indicates that the risk of the acute cerebral infarction is lower.
In summary, the application has the technical effects and advantages that:
1. the application has reasonable structure, when the preventive warning device is used, the collected blood sample is subjected to centrifugal layering, the plasma layer containing lysophosphatidic acid is positioned above the collecting test tube, the mixed solution of potassium dihydrogen phosphate and tetrabutylammonium hydroxide in the containing tube and plasma enter the chromatographic column simultaneously, the lysophosphatidic acid is separated from the plasma and enters the detector, the identification probe is used for detecting the result displayed on the data analyzer, the movable slide block is used for driving the trigger to move, the number of the lightened indicator lamps is changed, the quantity of the lysophosphatidic acid content can be known by observing the number of the lightened indicator lamps, when the quantity of the lightened indicator lamps reaches the position of the alarm, the alarm sounds, the incidence rate of acute cerebral infarction is higher, the alarm does not sound, the incidence rate of acute cerebral infarction is lower, when the secondary detection is carried out, the device automatically adjusts the last detection data, the indicator lamp on one of the two mounting card seats is lightened, after the secondary detection, the indicator lamp on the other mounting card seat is lightened, the quantity of the indicator lamp on the other mounting card seat is observed, the quantity of the two mounting card is changed, the situation can be better known, the preventive warning device can be better in time, and the preventive warning effect can be better realized, and the preventive warning effect can be better in time, and the preventive warning effect can be better on the situation of the people has a better and the preventive warning effect on the condition of the brain and can be better in comparison and the situation;
2. according to the application, the collected blood sample test tube is placed between the four movable clamping plates, the test tube can be stably fixed in the plurality of clamping grooves under the action of elastic deformation restoring force of the telescopic spring, the centrifugal motor is started, the centrifugal disc is rotated, the test tube is stably rotated, blood is divided into a blood cell layer and a blood plasma layer, the blood plasma layer containing lysophosphatidic acid is positioned above the test tube, the prevention and early warning equipment can more stably and rapidly detect and analyze the content of the lysophosphatidic acid in the blood, the detection result obtained by the prevention and early warning equipment is more accurate, and the prevention and early warning equipment can better detect and early warn the acute cerebral infarction;
3. according to the application, the hydraulic telescopic cylinder is started to drive the pressurizing pump body and the L-shaped connecting rod to move simultaneously, so that the position of the liquid suction pipe inserted into the plasma layer of the test tube and the position of the extrusion plug inserted into the holding cylinder are more uniform, a certain amount of plasma in the test tube and a certain amount of potassium dihydrogen phosphate and tetrabutylammonium hydroxide mixed solution in the holding cylinder enter the chromatographic column through the liquid inlet pipe simultaneously, so that lysophosphatidic acid in the plasma is separated, the separated lysophosphatidic acid enters the detector for analysis and detection, the measuring scale controls the amount of the plasma and the mixed solution, the detection and analysis of the lysophosphatidic acid content by the prevention and early warning equipment are facilitated, the prevention and early warning equipment can perform early warning prompt on the acute cerebral infarction condition more accurately, the prevention and early warning equipment is more stable in use, and the accuracy is higher;
4. according to the application, after the detector detects, the data analyzer can obtain the result, the identification probe identifies the result displayed on the data analyzer, the adjusting motor is started to drive the connecting screw rod to rotate, the movable sliding block is enabled to stably move, the side clamping plate is enabled to drive the identification probe to align to the position of the detection result, the trigger is enabled to move to change the position contacted with the receiver, after the identification probe aligns to the position of the detection result, the adjusting motor is stopped, the indicator lights are enabled to be lightened, when the lysophosphatidic acid content is low, the number of the lightened indicator lights is increased, when the side part of the alarm is provided with the lightened indicator lights, the alarm is enabled to simultaneously give out an alarm, so that the acute cerebral infarction incidence is higher, the prompt effect of the early warning device is better, the prompt effect of the early warning device is enabled to be more convenient and stable in use, the early warning effect of the patient can be better, and the personnel can better prevent the acute cerebral infarction from happening;
5. according to the application, when a patient is subjected to secondary detection, the equipment automatically calls the last detection data through the second alarm unit, so that the indicator light on one of the mounting clamping seats is turned on, and then after the secondary detection, the indicator light on the other mounting clamping seat is turned on, and the two detection results can be compared by observing the number of the turned-on indicator lights on the two mounting clamping seats, so that the condition degree can be known, the patient can be conveniently treated better, the practicability of the preventive early warning equipment is stronger, and the preventive early warning effect is better.
Based on the method, the blood centrifugation layering assembly can effectively separate blood plasma containing lysophosphatidic acid, the high performance liquid chromatography analysis assembly can separate the lysophosphatidic acid in the blood plasma, the control degree warning unit can give an alarm to the detection result, so that a patient can know the incidence degree of the acute cerebral infarction in time, a person with the illness state can better know the illness state in a period of time and treat the illness state, the practicability of the preventive early warning equipment is higher, and the preventive early warning effect is better.
Drawings
In order to more clearly illustrate the embodiments of the application or the technical solutions in the prior art, the drawings that are required in the embodiments or the description of the prior art will be briefly described, it being obvious that the drawings in the following description are only some embodiments of the application, and that other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
Fig. 1 is a schematic view of a perspective view of a first visual angle of an apparatus for early warning of acute cerebral infarction in embodiment 1 of the present application;
fig. 2 is a schematic internal perspective view of an apparatus for early warning of acute cerebral infarction in embodiment 1 of the present application;
FIG. 3 is an enlarged perspective view of a HPLC analysis module;
FIG. 4 is an enlarged schematic perspective view of a blood centrifuge layered assembly;
FIG. 5 is an enlarged perspective view of a preventive pre-warning trigger assembly;
fig. 6 is a schematic view of a second perspective view of the apparatus for early warning of acute cerebral infarction in embodiment 1 of the present application;
FIG. 7 is a partially enlarged perspective view of FIG. 6;
fig. 8 is a schematic perspective view of an apparatus for early warning of acute cerebral infarction in embodiment 2 of the present application.
In the figure: 1. a detection frame; 2. a support base; 3. fixing the side plates; 4. a hydraulic telescopic cylinder; 5. a data analyzer; 6. fixing the cross beam; 7. connecting a screw rod; 8. a chromatographic column; 9. fixing the upright post; 10. a detector; 11. an L-shaped mounting plate; 12. pressurizing the pump body; 13. a liquid suction pipe; 14. an L-shaped connecting rod; 15. a containing barrel; 16. a mounting frame; 17. a communicating pipe; 18. a liquid inlet conduit; 19. extruding the plug; 20. a graduated scale; 21. a fixed baffle; 22. a telescopic spring; 23. a movable clamping plate; 24. a centrifugal motor; 25. a centrifugal disc; 26. identifying a probe; 27. a side clamping plate; 28. a movable slide block; 29. a trigger; 30. a receiver; 31. adjusting a motor; 32. fixing the square blocks; 33. an indicator light; 34. installing a clamping seat; 35. an alarm.
Detailed Description
The following description of the embodiments of the present application will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present application, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the application without making any inventive effort, are intended to be within the scope of the application.
Example 1: referring to fig. 1, 6 and 7, the early warning device for acute cerebral infarction prevention comprises a detection frame 1, a support base 2 arranged at the bottom of the detection frame 1, and a blood centrifugation layering assembly for centrifuging collected blood arranged on the side wall of the detection frame 1, wherein the blood centrifugation layering assembly comprises a fixed side plate 3 arranged on the side wall of the detection frame 1, and the fixed side plate 3 can be any metal plate in the prior art and is welded and fixed with the side wall of the detection frame 1. The centrifugal motor 24 is installed at the bottom of the fixed side plate 3, and the centrifugal motor 24 can be fixed with the fixed side plate 3 through screw connection. The top of the fixed side plate 3 is provided with a rotating hole, the output end of the centrifugal motor 24 penetrates through the rotating hole, the output end of the centrifugal motor 24 is provided with a centrifugal disk 25, the top of the centrifugal disk 25 is provided with a plurality of uniformly arranged fixed baffle plates 21, the side walls of the fixed baffle plates 21 are provided with telescopic springs 22, one ends of the telescopic springs 22 are provided with movable clamping plates 23, the side walls of the movable clamping plates 23 are provided with clamping grooves, the advantage of the arrangement is that a collected blood sample test tube is placed between the four movable clamping plates 23, under the action of elastic deformation restoring force of the telescopic springs 22, the test tube can be stably fixed in the clamping grooves, the centrifugal motor 24 is started, the centrifugal disk 25 rotates, the test tube is stably rotated, blood is divided into a blood cell layer and a plasma layer, the plasma layer containing lysophosphatidic acid is positioned above the test tube, the device can more stably and rapidly detect and analyze the lysophosphatidic acid content in blood, the detection result obtained by the device is more accurate, the device can better detect and pre-warn the acute cerebral infarction, the high performance liquid chromatography component for extracting the blood separated by the blood centrifugal layering component is arranged on the detection frame 1, the high performance liquid chromatography component comprises an L-shaped mounting plate 11 arranged at the top of the detection frame 1, a detector 10 arranged on the inner wall of the bottom of the detection frame 1, a mounting frame 16 arranged on the side wall of the detection frame 1, the top of the detector 10 is provided with a preventive pre-warning triggering component, the bottom of the L-shaped mounting plate 11 is provided with a hydraulic telescopic cylinder 4, the output end of the hydraulic telescopic cylinder 4 is provided with a pressurizing pump body 12 and an L-shaped connecting rod 14, the water inlet end of the pressurizing pump body 12 is provided with a liquid suction pipe 13, the water outlet end of the pressurizing pump body 12 is provided with a liquid inlet pipe 18, one end of the L-shaped connecting rod 14 is provided with a squeezing plug 19, the top of the mounting frame 16 is provided with a holding cylinder 15, the squeezing plug 19 is adaptively arranged on the inner wall of the holding cylinder 15, the side wall of the holding cylinder 15 is provided with a water outlet hole, the inner wall of the water outlet hole is provided with a communicating pipe 17, the side wall of the liquid inlet pipe 18 is provided with a water inlet hole, one end of the communicating pipe 17 is arranged on the inner wall of the water inlet hole, one end of the liquid inlet pipe 18 is provided with a chromatographic column 8, the bottom end of the chromatographic column 8 is provided with a connecting pipe, one end of the connecting pipe is arranged on the side wall of the detector 10, the setting has the advantages that the hydraulic telescopic cylinder 4 is started to drive the pressurizing pump body 12 and the L-shaped connecting rod 14 to move simultaneously, so that the position of the liquid suction pipe 13 inserted into a test tube plasma layer and the position of the squeezing plug 19 inserted into the holding cylinder 15 are more unified, the lysophosphatidic acid in the plasma is separated out through the chromatographic column 8, the separated lysophosphatidic acid enters the detector 10 for analysis and detection, the prevention and early warning equipment can more accurately carry out early warning prompt on the acute cerebral infarction condition, the prevention and early warning equipment is more stable and has higher accuracy in use, the high performance liquid chromatography analysis component is provided with a prevention and early warning triggering component for prompting the detection result, the prevention and early warning triggering component comprises a fixed upright column 9 arranged at the top of the detector 10, the top of the fixed upright column 9 is provided with a data analyzer 5, the side wall of the data analyzer 5 is provided with two fixed blocks 32, the side wall of the two fixed blocks 32 is rotatably provided with a connecting screw rod 7, the connecting screw rod 7 is sleeved with a movable slide block 28, the side wall of the movable slide block 28 is provided with a side clamping plate 27, the side wall of the side clamping plate 27 is provided with an identification probe 26, the bottom of the movable sliding block 28 is provided with a trigger 29, the trigger 29 is adaptively arranged with a degree warning unit, the set advantage is that the data analyzer 5 obtains and displays a detection result, the identification probe 26 detects the result displayed on the data analyzer 5, the detection frame 1 is provided with a degree warning unit for warning, the degree warning unit comprises a fixed cross beam 6 arranged on the inner wall of the detection frame 1, the fixed cross beam 6 is provided with two mounting clamping seats 34, the two mounting clamping seats 34 are provided with a first warning unit for warning with single detection result and a second warning unit for comparing and warning with detection results at two sides, the side wall of the fixed cross beam 6 is provided with a receiver 30, the receiver 30 is adaptively arranged with the trigger 29, and the early warning triggering component is prevented from being adaptively arranged with the degree warning unit; the degree warning unit is used for giving out alarms of different degrees to the detection result. Through the setting of prevention early warning trigger subassembly, make blood centrifugation layering subassembly can effectively separate the plasma that contains lysophosphatidic acid, high performance liquid chromatography analysis subassembly separates out the lysophosphatidic acid in the plasma, control degree warning unit carries out the warning suggestion to the testing result, make patient can in time know the morbidity degree of self acute cerebral infarction, make the personnel that have the state of an illness can be better know the state of an illness degree in a period and treat, make prevention early warning equipment practicality stronger, prevention early warning effect is better.
In this embodiment, a scale 20 is installed on the side wall of the L-shaped mounting plate 11, a moving hole is formed on the side wall of the L-shaped mounting plate 11, a liquid inlet conduit 18 is adapted to be installed on the inner wall of the moving hole, and a mixed solution of potassium dihydrogen phosphate and tetrabutylammonium hydroxide is provided in the holding cylinder 15. The setting of the graduated scale 20 controls the amount of the plasma and the mixed solution, and is convenient for the prevention early warning equipment to detect and analyze the content of the lysophosphatidic acid.
In this embodiment, an adjusting motor 31 is mounted on a side wall of one of the fixed blocks 32, a connecting screw rod 7 is mounted at an output end of the adjusting motor 31, and a side wall of the movable slider 28 is in contact with a side wall of the data analyzer 5. Through the setting of movable slider 28, when making connecting lead screw 7 take place to rotate, can drive the more stable emergence of movable slider 28 and remove, make the prevention early warning equipment more stable when using.
In this embodiment, the first alarm unit includes a plurality of indicator lamps 33 installed on the top of the installation card seat 34 and arranged in a vertical connection manner, and an alarm 35 is installed on the side wall of the indicator lamp 33 located above. Through the setting of first alarm unit, make personnel in time know self acute cerebral infarction incidence degree, make prevention early warning equipment practicality stronger, the prevention early warning effect is better.
Example 2: unlike embodiment 1, referring to fig. 8, in this embodiment, the second alarm unit includes a plurality of indicator lamps 33 respectively mounted on the top of two mounting holders 34 and disposed in a vertical connection, and two alarms 35 are correspondingly mounted on the side walls of the upper part of the indicator lamps 33. Through the setting of second alarm unit, the personnel that make have the state of an illness can be better know the state of an illness in a period of time and the treatment, make prevention early warning equipment practicality stronger, prevention early warning effect is better.
The application also discloses a use method of the acute cerebral infarction prevention early warning device, which comprises the following steps:
s1, blood collection and separation: placing the collected blood sample tube between four movable clamping plates 23, and starting a centrifugal motor 24 to rotate the tube so as to separate the blood into a plasma layer containing lysophosphatidic acid and a blood cell layer not containing the lysophosphatidic acid;
s2, analyzing and detecting the content of lysophosphatidic acid: starting the hydraulic telescopic cylinder 4, enabling the pressurizing pump body 12 to drive the liquid suction pipe 13 to move downwards and insert into the test tube, enabling the liquid suction pipe 13 to be placed in a plasma layer, simultaneously starting the pressurizing pump body 12, enabling a certain amount of plasma to enter the liquid inlet conduit 18, enabling the mixed solution of potassium dihydrogen phosphate and tetrabutylammonium hydroxide in the containing cylinder 15 to enter the liquid inlet conduit 18 at the same time, enabling the plasma and the mixed solution to enter the chromatographic column 8 at the same time, further enabling lysophosphatidic acid to be separated out, and further entering the detector 10, and enabling the detector 10 to analyze and detect the content of the lysophosphatidic acid;
s3, alarming the degree of the detection result: the detection result is obtained through the data analyzer 5, the detection is carried out on the result displayed on the data analyzer 5 through the identification probe 26, the adjusting motor 31 is started, the movable sliding block 28 drives the trigger 29 to move, the quantity of the indication lamps 33 which are lightened changes through the contact positions between the trigger 29 and the receiver 30, the alarm 35 indicates that the risk of the acute cerebral infarction is higher when the alarm 35 sounds, and the alarm 35 does not sound indicates that the risk of the acute cerebral infarction is lower.
The working principle of the application is as follows: when the prevention early warning device is used, a blood centrifugation layering assembly is used for carrying out centrifugation layering on a collected blood sample, so that a plasma layer containing lysophosphatidic acid is positioned above a collection test tube, further, a high performance liquid chromatography analysis assembly is controlled, a hydraulic telescopic cylinder 4 is started, a pressurizing pump body 12 drives a liquid suction tube 13 to move downwards and insert into the test tube, the liquid suction tube 13 is placed in the plasma layer containing the lysophosphatidic acid, meanwhile, the pressurizing pump body 12 is started, a certain amount of plasma enters a liquid inlet conduit 18, a mixed solution of potassium dihydrogen phosphate and tetrabutylammonium hydroxide in a holding cylinder 15 enters the liquid inlet conduit 18 at the same time, then the plasma and the mixed solution enter a chromatographic column 8 at the same time, further, the lysophosphatidic acid is separated from the plasma, and further the lysophosphatidic acid enters a detector 10, the detector 10 is used for analyzing and detecting the content of the lysophosphatidic acid, the data analyzer 5 is used for obtaining and displaying a detection result, the identification probe 26 is used for detecting the result displayed on the data analyzer 5, the adjusting motor 31 is started, the movable sliding block 28 drives the trigger 29 to move, the quantity of the lighted indication lamps 33 is changed through the contact position between the trigger 29 and the receiver 30, the quantity of the lysophosphatidic acid content can be known by observing the quantity of the lighted indication lamps 33, the quantity of the lighted indication lamps 33 is larger when the content of the lysophosphatidic acid is lower, and when the quantity of the lighted indication lamps 33 reaches the position of the alarm 35, the alarm 35 is sounded, which indicates that the incidence rate of acute cerebral infarction is higher, and the alarm 35 is soundless, which indicates that the incidence rate of acute cerebral infarction is lower.
Through blood centrifugation layering subassembly, place the blood sample test tube of gathering between four movable clamp plates 23, under the elastic deformation restoring force effect of extension spring 22, make the test tube can be stable fix in a plurality of clamping grooves, and then start centrifugal motor 24, make centrifugal disk 25 take place to rotate, and then drive fixed stop 21, movable clamp plate 23 all take place to rotate, make stable rotation take place for the test tube, and then make blood divide into blood cell layer and plasma layer, the messenger contains the plasma layer of lysophosphatidic acid can be stable the subsidence in test tube top, make the prevention early warning equipment can be more stable quick carry out detection analysis to the lysophosphatidic acid content in the blood, the testing result that the prevention early warning equipment obtained is more accurate, make the prevention early warning equipment can be better detect the early warning to acute cerebral infarction state of illness.
Through high performance liquid chromatography analysis subassembly, make hydraulic telescoping cylinder 4 start, can drive pressurization pump body 12 and L shape connecting rod 14 and take place simultaneously and remove, make the position that drawing liquid pipe 13 inserted in the test tube plasma layer and the extrusion stopper 19 inserted in holding section of thick bamboo 15 more unified, make a certain amount of plasma in the test tube and hold a certain amount of potassium dihydrogen phosphate and tetrabutylammonium hydroxide mixed solution in the section of thick bamboo 15 and can get into chromatographic column 8 through feed liquor pipe 18 simultaneously, make lysophosphatidic acid in the plasma can be separated, make the lysophosphatidic acid that separates can get into detector 10 and carry out analytical detection, through scale 20, the volume of getting of plasma and mixed solution is controlled, be convenient for prevent the early warning equipment to carry out the analysis of lysophosphatidic acid content, make the early warning equipment of prevention can be more accurate carry out the early warning suggestion to acute cerebral infarction, make the prevention early warning equipment more stable during the state of an illness, the degree of accuracy is higher when using.
After the detector 10 detects, the result can be obtained through the data analyzer 5, the identification probe 26 is enabled to identify the result displayed on the data analyzer 5, the adjusting motor 31 is enabled to drive the connecting screw rod 7 to rotate, the movable sliding block 28 is enabled to stably move, the side clamping plate 27 is enabled to drive the identification probe 26 to align with the position of the detection result, the trigger 29 is enabled to move simultaneously, the position of the trigger 29 in contact with the receiver 30 is enabled to change, after the identification probe 26 aligns with the position of the detection result, the adjusting motor 31 is stopped, the indicating lamp 33 is enabled to be lightened, when the lysophosphatidic acid content is at the bottom, the number of the indicating lamps 33 is increased, when the indicating lamp 33 is lightened at the side of the alarm 35, the alarm 35 is enabled to simultaneously give out an alarm, the acute cerebral infarction incidence is higher, the prompt of a patient is high or low through the lightened indicating lamp 33, the prompt effect of the preventive early warning device is better, the number of the indicating the acute cerebral infarction incidence of the patient is enabled to be more convenient and stable in use, the preventive early warning device can play a better preventive warning effect on the patient.
When carrying out secondary to patient and detecting, through the second alarm unit that sets up, make equipment automatically regulated detect data last time, make the pilot lamp 33 on one of them installation cassette 34 light, and then behind the secondary detection, make the pilot lamp 33 on another installation cassette 34 light, quantity that the pilot lamp 33 on through observing two installation cassettes 34 light makes the twice testing result can obtain the contrast, can know the good or bad degree of state of an illness, the patient of being convenient for carries out better treatment, make prevention early warning equipment practicality stronger, prevention early warning effect is better.
Finally, it should be noted that: the foregoing description is only illustrative of the preferred embodiments of the present application, and although the present application has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that modifications may be made to the embodiments described, or equivalents may be substituted for elements thereof, and any modifications, equivalents, improvements or changes may be made without departing from the spirit and principles of the present application.

Claims (3)

1. The utility model provides an acute cerebral infarction prevention early warning equipment, includes detection frame (1), install in support base (2) of detection frame (1) bottom, its characterized in that: the blood centrifugal layering assembly for centrifuging collected blood is arranged on the side wall of the detection frame (1), the high performance liquid chromatography analysis assembly for extracting blood plasma separated by the blood centrifugal layering assembly is arranged on the detection frame (1), the prevention early warning triggering assembly for prompting a detection result is arranged on the high performance liquid chromatography analysis assembly, the degree warning unit for warning is arranged on the detection frame (1), and the prevention early warning triggering assembly is arranged in a matched mode with the degree warning unit; the degree warning unit is used for giving alarms of different degrees to the detection result; the high performance liquid chromatography component comprises an L-shaped mounting plate (11) arranged at the top of the detection frame (1), a detector (10) arranged on the inner wall of the bottom of the detection frame (1), and a mounting rack (16) arranged on the side wall of the detection frame (1), wherein the top of the detector (10) is provided with the preventive early warning trigger component, the bottom of the L-shaped mounting plate (11) is provided with a hydraulic telescopic cylinder (4), the output end of the hydraulic telescopic cylinder (4) is provided with a pressurizing pump body (12) and an L-shaped connecting rod (14), the water inlet end of the pressurizing pump body (12) is provided with a liquid suction pipe (13), the water outlet end of the pressurizing pump body (12) is provided with a liquid inlet guide pipe (18), one end of the L-shaped connecting rod (14) is provided with a squeezing plug (19), the top of the mounting rack (16) is provided with a containing cylinder (15), the squeezing plug (19) is matched with the inner wall of the containing cylinder (15), the side wall of the containing cylinder (15) is provided with a water outlet hole, the water inlet end of the water inlet guide pipe (18) is provided with a water inlet guide pipe (18), one end of the water inlet guide pipe (8) is provided with a water inlet guide pipe (18), one end of the connecting conduit is mounted on the side wall of the detector (10); a graduated scale (20) is arranged on the side wall of the L-shaped mounting plate (11), a moving hole is formed in the side wall of the L-shaped mounting plate (11), the liquid inlet guide pipe (18) is adaptively arranged on the inner wall of the moving hole, and a mixed solution of potassium dihydrogen phosphate and tetrabutylammonium hydroxide is arranged in the accommodating cylinder (15); the early warning prevention triggering assembly comprises a fixed upright post (9) arranged at the top of the detector (10), a data analyzer (5) is arranged at the top end of the fixed upright post (9), two fixed blocks (32) are arranged on the side wall of the data analyzer (5), a connecting screw rod (7) is rotatably arranged on the side wall of each fixed block (32), a movable sliding block (28) is sleeved on the connecting screw rod (7), a side clamping plate (27) is arranged on the side wall of each movable sliding block (28), an identification probe (26) is arranged on the side wall of each side clamping plate (27), a trigger (29) is arranged at the bottom of each movable sliding block (28), and the triggers (29) are arranged in a matched mode with the degree warning unit; an adjusting motor (31) is arranged on the side wall of one fixed square block (32), the output end of the adjusting motor (31) is provided with the connecting screw rod (7), and the side wall of the movable sliding block (28) is contacted with the side wall of the data analyzer (5); the degree warning unit comprises a fixed cross beam (6) arranged on the inner wall of the detection frame (1), two mounting clamping seats (34) are arranged on the fixed cross beam (6), a first warning unit for warning a single detection result and a second warning unit for comparing and warning detection results at two sides are arranged on the two mounting clamping seats (34), a receiver (30) is arranged on the side wall of the fixed cross beam (6), and the receiver (30) is adaptively arranged with the trigger (29); the first alarm unit comprises a plurality of indicator lamps (33) which are arranged at the top of the mounting clamping seat (34) in a vertical connection manner, and an alarm (35) is arranged on the side wall of the indicator lamp (33) positioned above the indicator lamps; the second alarm unit comprises a plurality of indicator lamps (33) which are vertically connected and arranged and are respectively arranged at the tops of the two mounting clamping seats (34), and two alarms (35) are correspondingly arranged on the side wall of the indicator lamp (33) positioned above.
2. The acute cerebral infarction prevention warning device as set forth in claim 1, wherein: the blood centrifugation layering subassembly including install in fixed curb plate (3) on detection frame (1) lateral wall, centrifugal motor (24) are installed to the bottom of fixed curb plate (3), rotation hole has been seted up at the top of fixed curb plate (3), the output of centrifugal motor (24) run through in rotation hole, centrifugal dish (25) are installed to the output of centrifugal motor (24), fixed baffle (21) of a plurality of evenly setting are installed at the top of centrifugal dish (25), a plurality of telescopic spring (22) are all installed on the lateral wall of fixed baffle (21), a plurality of movable clamp plate (23) are all installed to the one end of telescopic spring (22), a plurality of clamping groove has all been seted up on the lateral wall of movable clamp plate (23).
3. A method of using an acute cerebral infarction prevention forewarning device as claimed in any one of claims 1 to 2, the method comprising:
s1, blood collection and separation: placing the collected blood sample test tube between four movable clamping plates (23), starting a centrifugal motor (24) to rotate the test tube, so that the blood is divided into a blood plasma layer containing lysophosphatidic acid and a blood cell layer not containing the lysophosphatidic acid, and the blood plasma layer containing the lysophosphatidic acid is positioned above the test tube;
s2, analyzing and detecting the content of lysophosphatidic acid: starting a hydraulic telescopic cylinder (4), enabling a pressurizing pump body (12) to drive a liquid suction pipe (13) to move downwards and insert into a test tube, enabling the liquid suction pipe (13) to be placed in a plasma layer, simultaneously starting the pressurizing pump body (12), enabling a certain amount of plasma to enter a liquid inlet pipe (18), enabling a mixed solution of potassium dihydrogen phosphate and tetrabutylammonium hydroxide in a containing cylinder (15) to enter the liquid inlet pipe (18) at the same time, enabling the plasma and the mixed solution to enter a chromatographic column (8) at the same time, enabling lysophosphatidic acid to be separated out, enabling the liquid suction pipe to enter a detector (10), and enabling the detector (10) to analyze and detect the content of the lysophosphatidic acid;
s3, alarming the degree of the detection result: the detection result is obtained through the data analyzer (5), the detection is carried out on the result displayed on the data analyzer (5) through the identification probe (26), the adjusting motor (31) is started, the movable sliding block (28) drives the trigger (29) to move, the quantity of the indication lamps (33) which are lightened changes through the contact positions between the trigger (29) and the receiver (30), the alarm (35) indicates that the risk of the acute cerebral infarction is higher when the alarm (35) sounds, and the alarm (35) does not sound indicates that the risk of the acute cerebral infarction is lower.
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