CN113564920A - Medical care protective fabric for burns and preparation method thereof - Google Patents
Medical care protective fabric for burns and preparation method thereof Download PDFInfo
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- CN113564920A CN113564920A CN202110777985.9A CN202110777985A CN113564920A CN 113564920 A CN113564920 A CN 113564920A CN 202110777985 A CN202110777985 A CN 202110777985A CN 113564920 A CN113564920 A CN 113564920A
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- D—TEXTILES; PAPER
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- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M13/00—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Abstract
The invention discloses a preparation method of medical care protective fabric for burns, which comprises the following steps of firstly weighing traditional Chinese medicine extracts with antibacterial effect; then adding the weighed traditional Chinese medicine extract into a proper amount of deionized water, heating to 50 ℃ in a water bath, and stirring until the extract is completely dissolved; placing the cotton fabric into a beaker, boiling and refining with alkali, and removing cotton wax; soaking cotton fabric with cotton wax removed in the prepared Chinese medicinal solution for 24 hr, taking out, and oven drying at 60 deg.C until completely dried. Scanning electron microscope picture and infrared spectroscopy prove that effective components in the traditional Chinese medicine are fully integrated into the burn curing fabric, the curing effect of the traditional Chinese medicine can be fully exerted, the traditional Chinese medicine becomes an effective medical curing protective material, the effective components of the traditional Chinese medicine can be uniformly distributed by adding the adhesive, and the uniformity of material performance is improved.
Description
Technical Field
The invention belongs to the technical field of medical materials, and particularly relates to medical care protective fabric for burns and a preparation method thereof.
Background
Burn is a very common symptom in clinic at present, and most of the burn is skin damage caused by heat. Because the first protective immune barrier of the skin is lost, when patients cannot get treatment in time, infection, inflammation reaction and even death are easy to happen. At present, common gauze with vaseline serving as dressing is mostly used for wrapping up a wound surface clinically, but the dressing only can cover the wound surface, and for inflammation, oral antibiotics are mostly adopted for treatment, although oral antibiotics can remove bacteria in vivo, the effect on bacteria on the surface of a burn wound is poor, and the bacteria can generate drug resistance due to the use of the antibiotics, so that the subsequent treatment is difficult. Meanwhile, in the process of wound healing, pruritus can be generated, discomfort of a patient can be caused, and even mental adverse effects such as anxiety or depression can be caused to the patient. These all seriously affect the healing and rehabilitation of the wound of the patient. Therefore, the medical care protective fabric applied to burn wounds has a huge application prospect.
Disclosure of Invention
In order to overcome the defects in the prior art, the invention aims to provide a medical care protective fabric for burns and a preparation method thereof.
In order to achieve the purpose, the invention relates to a preparation method of medical care protective fabric for burns, which specifically comprises the following steps:
(1) weighing the traditional Chinese medicine extract with antibacterial effect;
(2) adding the traditional Chinese medicine extract weighed in the step (1) into a proper amount of deionized water, heating to 50 ℃ in a water bath, and stirring until the extract is completely dissolved;
(3) placing the cotton fabric into a beaker, boiling with alkali, and removing cotton wax to facilitate the subsequent adsorption process of the traditional Chinese medicine components;
(4) soaking the cotton fabric with the cotton wax removed in the traditional Chinese medicine solution obtained in the step (2) for 24 hours, taking out the cotton fabric, and drying the cotton fabric in an oven at 60 ℃ until the cotton fabric is completely dried.
Preferably, the antibacterial herbal extract includes, but is not limited to, one or more of kochia scoparia extract, smilax glabra extract, dictamnus dasycarpus extract, red peony root extract, angelica sinensis extract, saposhnikovia divaricata extract, bletilla striata extract or honeysuckle flower extract.
More preferably, the traditional Chinese medicine extract comprises the following components in parts by weight: 1 part of fructus kochiae extract, 1 part of rhizoma smilacis glabrae extract, 1 part of cortex dictamni extract, 1 part of radix paeoniae rubra extract, 0.6 part of angelica sinensis extract, 0.5 part of radix sileris extract, 0.5 part of bletilla striata extract and 0.5 part of honeysuckle extract.
Further, the binder is added into the completely dissolved traditional Chinese medicine solution in the step (2), and the content of the binder in the traditional Chinese medicine solution is 0.05-1%. The adhesive is acrylate adhesive, water polyurethane adhesive, fibrin adhesive, etc.
The invention has the beneficial effects that: scanning electron microscope picture and infrared spectroscopy prove that effective components in the traditional Chinese medicine are fully integrated into the burn curing fabric, the curing effect of the traditional Chinese medicine can be fully exerted, the traditional Chinese medicine becomes an effective medical curing protective material, the effective components of the traditional Chinese medicine can be uniformly distributed by adding the adhesive, and the uniformity of material performance is improved.
Drawings
FIG. 1 is an SEM photograph of medical protective fabrics for burns prepared in examples 1-6.
FIG. 2 is an SEM of the face fabric before and after the post-treatment of example 7, wherein the left is before the post-treatment and the right is after the post-treatment.
FIG. 3 is an IR spectrum (blank) of cotton fabric from example 1 with facial wax removed.
Fig. 4 is an infrared spectrum of the medical protective fabric for burns prepared in example 1.
Fig. 5 is an infrared spectrum of the medical protective fabric for burns prepared in example 2.
Fig. 6 is an infrared spectrum of the medical protective fabric for burns prepared in example 3.
Fig. 7 is an infrared spectrum of the medical protective fabric for burns prepared in example 4.
Fig. 8 is an infrared spectrum of the medical protective fabric for burns prepared in example 5.
Fig. 9 is an infrared spectrum of the medical protective fabric for burns prepared in example 6.
Detailed Description
The technical scheme of the invention is further explained by the specific implementation mode in combination with the attached drawings.
Example 1
The preparation method of the medical care protective fabric for burns related to the embodiment specifically comprises the following steps:
(1) weighing the following traditional Chinese medicine extracts by weight: 1g of fructus kochiae extract, 1g of rhizoma smilacis glabrae extract, 1g of cortex dictamni extract, 1g of radix paeoniae rubra extract, 0.6g of angelica sinensis extract, 0.5g of radix sileris extract, 0.5g of bletilla striata extract and 0.5g of honeysuckle extract;
(2) adding the traditional Chinese medicine extract weighed in the step (1) into 100ml of deionized water, heating to 50 ℃ in a water bath, and stirring until the traditional Chinese medicine extract is completely dissolved;
(3) placing the cotton fabric into a beaker, boiling with alkali, and removing cotton wax to facilitate the subsequent adsorption process of the traditional Chinese medicine components;
(4) soaking the cotton fabric with the cotton wax removed in the completely dissolved traditional Chinese medicine solution obtained in the step (2) for 24 hours, taking out the cotton fabric, and drying the cotton fabric in an oven at 60 ℃ until the cotton fabric is completely dried.
The traditional Chinese medicine extract is 1 kg of effective component powder extracted from 200 jin of raw materials and is directly purchased.
In the traditional Chinese medicine extract formula, the broom cypress fruit extract with high content is adopted, wherein the triterpenoid saponin in the broom cypress fruit extract has the effects of anti-inflammation, anti-allergy and the like. The dictamnine and corticosterone contained in the cortex dictamni extract also have good antibacterial function, and simultaneously have anti-inflammatory and anti-allergic effects, and have good growth inhibition effect on common strains at burn wounds, such as escherichia coli, staphylococcus aureus and the like. The glabrous greenbrier rhizome extract in the formula contains a large amount of flavonoids and a large amount of saponins, has good anti-inflammatory and antibacterial effects, and can also play a role in relieving pain. The red peony root has the functions of clearing heat and cooling blood, and removing blood stasis and relieving pain, and the red peony root extract contains a large amount of paeoniflorin, so that cells can be prevented from being damaged by oxidation, exposed cells at a wound can be effectively protected, apoptosis can be inhibited, a cell adenosine A1 receptor can be activated, a sodium ion channel can be blocked, and calcium ion overload damage of the cells can be relieved to protect nerve cells at the wound. Ethyl palmitate, ethyl linoleate, etc. have good anti-inflammatory effect. The radix Angelicae sinensis extract has effects of promoting blood circulation and relieving pain, and radix Saposhnikoviae has effects of relieving pain, resisting inflammation and enhancing immunity. The honeysuckle extract and the bletilla striata extract can effectively inhibit the growth of staphylococcus aureus and pseudomonas aeruginosa, and meanwhile, the bletilla striata extract can also promote healing of burn wounds, so that the bletilla striata extract is a good auxiliary medicinal material.
Example 2
The present example is the same as example 1 except for the herb extracts in step (1).
(1) Weighing the following traditional Chinese medicine extracts by weight: 2g of fructus kochiae extract, 2g of rhizoma smilacis glabrae extract, 2g of cortex dictamni extract, 2g of radix paeoniae rubra extract, 1.2g of angelica sinensis extract, 1g of radix sileris extract, 1g of bletilla striata extract and 1g of honeysuckle extract.
Example 3
The present example is the same as example 1 except for the herb extracts in step (1).
(1) Weighing the following traditional Chinese medicine extracts by weight: 0.5g of honeysuckle extract.
Example 4
The present example is the same as example 1 except for the herb extracts in step (1).
(1) Weighing the following traditional Chinese medicine extracts by weight: rhizoma Smilacis Glabrae extract 1 g.
Example 5
The present example is the same as example 1 except for the herb extracts in step (1).
(1) Weighing the following traditional Chinese medicine extracts by weight: cortex Dictamni Radicis extract 1 g.
Example 6
The present example is the same as example 1 except for the herb extracts in step (1).
(1) Weighing the following traditional Chinese medicine extracts by weight: bletilla striata extract 0.5 g.
Example 7
The present example is the same as example 1 except for the herb extracts in step (1).
(1) Weighing the following traditional Chinese medicine extracts by weight: 1g of fructus kochiae extract, 1g of rhizoma smilacis glabrae extract, 1g of cortex dictamni extract, 1g of radix paeoniae rubra extract, 0.6g of angelica sinensis extract, 0.5g of radix sileris extract, 0.5g of bletilla striata extract and 0.5g of honeysuckle extract;
(2) adding the traditional Chinese medicine extract weighed in the step (1) into 100ml of deionized water, heating to 50 ℃ in a water bath, and stirring until the traditional Chinese medicine extract is completely dissolved;
(3) placing the cotton fabric into a beaker, boiling with alkali, and removing cotton wax to facilitate the subsequent adsorption process of the traditional Chinese medicine components;
(4) adding the adhesive into the traditional Chinese medicine solution, and uniformly mixing, wherein the adhesive in the traditional Chinese medicine solution is 1%;
(5) and (4) soaking the cotton fabric with the cotton wax removed in the traditional Chinese medicine solution obtained in the step (3) for 24 hours, taking out the cotton fabric, and drying the cotton fabric in an oven at 60 ℃ until the cotton fabric is completely dried.
Scanning electron microscope tests were performed on the fabrics prepared in examples 1 to 6, respectively, and the results, as shown in fig. 1, show that: the effective components of the traditional Chinese medicine are loaded on the surface of the fabric fiber, and the post-finishing method of soaking the fabric fiber by adopting the traditional Chinese medicine extract solution is practical and effective. However, the fabric is directly immersed in the traditional Chinese medicine extract solution, so that the problems of uneven distribution and easy agglomeration of traditional Chinese medicine components are easily caused. Example 7 the binder is added in the post-treatment process, and scanning electron microscope examination of the fabric before and after treatment in example 7 respectively shows that the binder can realize uniform distribution of the traditional Chinese medicine components.
The medical functional fabric used in the burn wound should ensure good moisture permeability, and the knitted fabric using cotton fiber itself has less moisture permeability, but the properties may be changed by adding the traditional Chinese medicine materials, so the fabrics prepared in examples 1 to 6 were subjected to the fabric moisture permeability test. Moisture permeability was measured using a model YG601H computerized textile inspection machine. Specifically, an evaporation method is adopted to determine the moisture absorption and air permeability of the fabric by measuring the perspective ratio of the fabric.
In carrying out the experiment, a mask sample of a prescribed shape was first prepared, the sample having an area of 0.0028 square meters. Then 34ml of distilled water was measured with a measuring cylinder precision and poured into a clean and dry see-through cup, and then the sample to be measured was placed on the see-through cup. And (5) installing a pressure ring, and sealing the side surface of the pressure ring by using an ethylene adhesive tape to prepare an experimental body. Then, the instrument was preheated to balance the temperature and humidity of the instrument at 37 ℃ and 50 ℃. The fabric fabrics prepared in examples 1-6 were placed together in a test chamber and weighed one by one after 1h of balance, and then weighed again in sequence after 1h of testing. After weighing, the calculation results of the transmittance (WVT) of the six groups of samples and the blank control group are calculated according to the formula as shown in the following table:
the bacteriostatic effect of the Chinese medicinal materials is often determined by the functional groups contained therein, and thus, the fabrics prepared in examples 1 to 6 were subjected to the microscopic infrared test, as shown in FIGS. 2 to 7. The fabric article prepared in example 1 was found to have significantly improved absorption in the infrared spectrum between 3300-. Correspondingly, the functional group absorbing the infrared spectrum between 3300-4000 is mainly amide group with-NH, the functional group absorbing the infrared spectrum between 1900-2300 is mainly alcohol and phenol and also triple bond, and the functional group absorbing the infrared spectrum between 850-950 is mainly olefin and terpenoid. The fabric prepared in example 2 is very similar to the fabric prepared in example 1, and the difference of the infrared absorption spectra between 1900-2350 is large, and considering that the difference between the two groups of samples is mainly concentration, the effective functional groups of the traditional Chinese medicine material are preliminarily judged to be alcohol and phenol and also triple bonds.
The fabric prepared in example 3 differs from the blank control group mainly in 1900-. The fabric prepared in example 5 differs from the blank control mainly between 3300-4000 and 1900-2300. The fabric prepared in example 6 differed from the blank control group primarily between 850 and 950.
Example 3 adopts the main chemical components of chlorogenic acid and caffeic acid in honeysuckle, which contain a large amount of-OH, which may cause the great reduction of the transmittance of the infrared spectrum between 1900-; the smilax glabra of example 4 has complex chemical components and contains a plurality of effective chemical functional groups, so that the transmittance of the whole infrared spectrum is poor; the cortex dictamni of example 5 contains a large amount of fraxinellone, phellodendron ketone and dictamnine, thus resulting in a high infrared absorption rate between 3300-. The bletilla striata in example 6 contains abundant terpenoids and the like, so that the absorption rate of the infrared spectrum between 850 and 950 is higher.
Claims (5)
1. A preparation method of medical care protective fabric for burns is characterized by comprising the following steps:
(1) weighing the traditional Chinese medicine extract with antibacterial effect;
(2) adding the traditional Chinese medicine extract weighed in the step (1) into a proper amount of deionized water, heating to 50 ℃ in a water bath, and stirring until the extract is completely dissolved;
(3) placing the cotton fabric into a beaker, boiling with alkali, and removing cotton wax to facilitate the subsequent adsorption process of the traditional Chinese medicine components;
(4) soaking the cotton fabric with the cotton wax removed in the traditional Chinese medicine solution obtained in the step (2) for 24 hours, taking out the cotton fabric, and drying the cotton fabric in an oven at 60 ℃ until the cotton fabric is completely dried.
2. The method for preparing a medicated protective fabric for burns according to claim 1, wherein the antibacterial traditional Chinese medicine extract is one or more of fructus kochiae extract, rhizoma smilacis glabrae extract, cortex dictamni extract, radix paeoniae rubra extract, radix angelicae sinensis extract, radix sileris extract, rhizoma bletillae extract or flos lonicerae extract.
3. The preparation method of the medical care protective fabric for burns according to claim 1, wherein the traditional Chinese medicine extract comprises the following components in parts by weight: 1 part of fructus kochiae extract, 1 part of rhizoma smilacis glabrae extract, 1 part of cortex dictamni extract, 1 part of radix paeoniae rubra extract, 0.6 part of angelica sinensis extract, 0.5 part of radix sileris extract, 0.5 part of bletilla striata extract and 0.5 part of honeysuckle extract.
4. The preparation method of the medical care protective fabric for burns according to claim 1, wherein the binder is added into the completely dissolved traditional Chinese medicine solution in the step (2), and the content of the binder in the traditional Chinese medicine solution is 0.05-1%.
5. The method for preparing a medical care protective fabric for burn according to claim 4, wherein the adhesive is acrylate adhesive, aqueous polyurethane adhesive or fibrin adhesive.
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| CN1306833A (en) * | 2000-01-21 | 2001-08-08 | 卫和平 | External-use extract for treating burns and scalds fast and its preparation |
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| CN106087387A (en) * | 2016-06-18 | 2016-11-09 | 张阳康 | A kind of antibacterial composite fabric containing traditional Chinese medicine extraction component |
| CN109497638A (en) * | 2018-12-13 | 2019-03-22 | 北京方诣生物医药有限公司 | A kind of Traditional Chinese medicine bacteriostatic mask |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1306833A (en) * | 2000-01-21 | 2001-08-08 | 卫和平 | External-use extract for treating burns and scalds fast and its preparation |
| CN101138648A (en) * | 2006-09-07 | 2008-03-12 | 电子科技大学中山学院 | Method of preparing antimicrobial hemostasis Chinese medicine-containing biological dressings |
| CN201676082U (en) * | 2009-08-05 | 2010-12-22 | 金庆国 | Burning-caused inflammation eliminating swab for medical use |
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Application publication date: 20211029 |