CN113559407B

CN113559407B - Fixing device for improving treatment effect of liver targeting drug

Info

Publication number: CN113559407B
Application number: CN202110853233.6A
Authority: CN
Inventors: 陈磊峰; 杜云艳; 陈浩
Original assignee: Second Affiliated Hospital to Nanchang University
Current assignee: Second Affiliated Hospital to Nanchang University
Priority date: 2021-07-27
Filing date: 2021-07-27
Publication date: 2022-10-18
Anticipated expiration: 2041-07-27
Also published as: CN113559407A

Abstract

The invention discloses a fixing device for improving the treatment effect of a liver targeting drug, relates to the technical field of medical equipment, and solves the problem that the position of an existing fixing device cannot be adjusted according to the position of a patient when the existing fixing device is used. A fixing device for improving the treatment effect of a liver targeting drug comprises a carrying frame and main magnetic equipment, wherein the left side and the right side of the carrying frame are respectively provided with a restraining belt, and the other ends of the two restraining belts are respectively provided with two fixing belts; the left side and the right side of the inner part of the carrying frame are both provided with a sliding chute, and two guide rods are arranged in the two sliding chutes through springs; two main magnetic devices are sleeved and slidably arranged on the guide rods. The invention drives the main magnetic device to move up and down by sliding the two guide rods along the two sliding grooves, adjusts the up and down position of the main magnetic device, and adjusts the left and right position of the main magnetic device by sliding the main magnetic device left and right along the guide rods, and the selection of the adjusting position is wider.

Description

Fixing device for improving treatment effect of liver targeting drug

Technical Field

The invention relates to the technical field of medical equipment, in particular to a fixing device for improving the treatment effect of a liver targeting drug.

Background

The targeted therapy is a treatment mode aiming at a definite carcinogenic site on a cellular molecular level, and the liver targeted therapy is actually a gene therapy, can use a mature targeted drug to regulate and control a plurality of genes generating pathological conditions and multiple target points, and has a good effect.

For example, patent No. CN201410072934.6 discloses a brain-targeted nasal drug delivery device and a posture fixer thereof. A brain-targeted intranasal drug delivery device comprising: a body position fixer for keeping the body position of the user to make the medicine administrated through the nasal cavity enter the olfactory region of the specific upper nasal cavity; and the administration end of the administration device is in a shape matched with the nasal cavity of the user, and is used for administering the medicine to the user through the nasal cavity and directionally entering the brain under the condition that the user is kept in the posture by the posture fixer. Specifically, the posture fixer includes: a head carrying portion for carrying the head of a user and holding the head such that a medicament administered via the nasal cavity can enter the olfactory region of the upper nasal cavity. Wherein, head bearing part includes: the headrest support comprises a headrest for carrying the head of a user, a support frame and a central shaft for rotatably supporting the headrest on the support frame. Through keeping the user at specific position of dosing to by intelligent component control, make the medicine of dosing through the nasal cavity can regularly, the paces, ration get into the smelly district of nasal cavity, and target effect is to the brain.

When the existing fixing device is used, the position of the existing fixing device cannot be well adjusted according to the affected part of a patient, so that the magnetic targeting preparation in the body of the patient cannot accurately respond to the position of external magnetic equipment, and the magnetic targeting preparation cannot accurately contact with a target part, and the treatment effect is poor.

Disclosure of Invention

The invention aims to provide a fixing device for improving the treatment effect of a liver targeting drug, and aims to solve the problem that when the existing fixing device provided in the background art is used, the position of the existing fixing device cannot be well adjusted according to the position of a patient, so that a magnetic targeting preparation in the body of the patient cannot accurately respond to the position of an external magnetic device.

In order to achieve the purpose, the invention provides the following technical scheme: a fixing device for improving the treatment effect of a liver targeting drug comprises a carrying frame; the left side and the right side of the interior of the carrying frame are both provided with a sliding chute, two guide rods are arranged in the two sliding chutes through springs, and the two guide rods are of cylindrical rod-shaped structures; a main magnetic device is sleeved and slidably arranged on the two guide rods, and the main magnetic device is of a rectangular structure; four corners of the front side of the main magnetic device are respectively provided with a cross arm block, and the four cross arm blocks are of triangular structures; the left end and the right end of the front side of the carrying frame are respectively provided with a loading shell, and the two loading shells are rectangular structures; the carrying frame is of a rectangular structure, the left side and the right side of the carrying frame are both provided with a binding belt, and the other ends of the two binding belts are both provided with two fixing belts.

Preferably, the main magnetic device includes: the front plate is arranged on the front side of the main magnetic equipment and is of a rectangular structure; eleven rows of fixing grooves are arranged on the front side of the front plate at equal intervals from left to right; the main magnetic device further includes: the side groove is formed in the right side of the main magnetic device and is of a rectangular structure; and the two rows of fixture blocks are respectively arranged on the upper side and the lower side of the side groove.

Preferably, the loading case includes: the two threaded rods are respectively arranged on the front sides of the two loading shells, and the front ends of the two threaded rods are respectively provided with a hand wheel; the two push plates are respectively arranged inside the two loading shells in a sliding manner, are of a rectangular structure, and are respectively connected with the rear ends of the two threaded rods in a rotating manner at the front sides; and the two rows of the inserted rods are arranged at the rear sides of the two push plates at intervals from top to bottom at equal intervals respectively.

Preferably, the stretcher comprises: the lantern ring is arranged on the inner sides of the four carrying blocks through springs and is of a circular structure; the strong magnetic equipment is arranged inside the lantern ring; the stretcher block further comprises: the fixed rod is slidably arranged on the front side of the powerful magnetic equipment and is of a cylindrical rod-shaped structure; the baffle disc is arranged at the front end of the fixing rod and is of a disc-shaped structure, and a spring is arranged in front of the rear side of the baffle disc and the front side of the strong magnetic equipment.

Preferably, the guide bar includes: the left plate is arranged at the left ends of the two guide rods and is of a waist-shaped structure; the right plate is arranged at the right ends of the two guide rods and is of a waist-shaped structure; the guide arm still includes: the two rows of slots are respectively arranged on the front sides of the left plate and the right plate at equal intervals from top to bottom; two inner grooves are arranged and arranged on the left side of the right plate in an up-down symmetrical manner; the guide arm still includes: the two sliding columns are respectively arranged in the two inner grooves in a sliding manner, and are of cylindrical columnar structures; the support plate is arranged in the middle of the right side of the left plate, the support plate is of a rectangular structure, and the right side of the support plate is connected with the left side of the right plate; the two clamping plates are respectively arranged at the left ends of the two sliding columns, and a row of clamping grooves are formed in the outer sides of the two clamping plates; the guide arm still includes: the sleeve plate is sleeved and slidably mounted on the support plate, and two springs are arranged between the left side of the sleeve plate and the right side of the left plate; and the two connecting rods are arranged and rotatably arranged on the right side of the sleeve plate in an up-down symmetrical manner, and the other ends of the two connecting rods are connected with the left end of one clamping plate through bearings.

Compared with the prior art, the invention has the beneficial effects that:

1. the main magnetic device is driven to move up and down by sliding the two guide rods along the two sliding grooves, the up-and-down position of the main magnetic device is adjusted, the left-and-right position of the main magnetic device is adjusted by sliding the main magnetic device left and right along the guide rods, the adjusting position is wide in selection range, and the device can adjust the position according to the position of a patient, so that the problem that the preparation cannot accurately respond to the position of the main magnetic device and cannot be guided to a target position due to the fact that the magnetic target preparation in the patient is too far away from the position of the main magnetic device is avoided.

2. The invention carries out basic attraction and guidance on the preparation in the human body through the main magnetic equipment, so that the preparation is attracted to the position close to the target position, and then the strong magnetic equipment is moved, and the magnetic force of the strong magnetic equipment is greater than that of the main magnetic equipment, so that the strong magnetic equipment can drive the magnetic target preparation swallowed by the patient to move in the human body, and the preparation is precisely adjusted in position, so that the preparation can be precisely guided to the target position, the target position can conveniently absorb the preparation, the treatment effect of the preparation is improved, and the method for precisely adjusting the position of the preparation by using the strong magnetic equipment is flexible and simple to operate.

Drawings

FIG. 1 is a schematic structural view of the present invention;

FIG. 2 is a right side schematic view of the present invention;

FIG. 3 is a schematic view of the structure of the loading frame and the loading shell of the present invention;

FIG. 4 is a schematic diagram of the structure of the guide rod and the left plate according to the present invention;

FIG. 5 is a schematic view of an enlarged portion A of FIG. 4 according to the present invention;

FIG. 6 is a schematic diagram of a portion of the structure of FIG. 4B;

FIG. 7 is a schematic view of a half-section of a main magnetic device according to the present invention;

fig. 8 is a schematic diagram of the structure of the primary magnetic device and the cross-bar of the present invention;

FIG. 9 is a schematic view of the structure of the pole piece and strong magnetic device of the present invention;

FIG. 10 is a schematic view of a half-section of the loading shell of the present invention;

in the figure: 1. carrying a frame; 2. a guide bar; 201. a left panel; 202. a right plate; 203. inserting slots; 204. an inner tank; 205. a traveler; 206. a support plate; 207. clamping a plate; 208. sheathing; 209. a connecting rod; 3. a main magnetic device; 301. a front plate; 302. a fixing groove; 303. a side groove; 304. a clamping block; 4. carrying a shoulder block; 401. a collar; 402. a powerful magnetic device; 403. fixing the rod; 404. a catch tray; 5. loading a shell; 501. a threaded rod; 502. pushing the plate; 503. and (4) inserting a rod.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments.

Referring to fig. 1 to 10, an embodiment of the present invention: a fixation device for improving the therapeutic effect of a liver-targeted drug, comprising:

as shown in fig. 1, 2, 4, 5 and 6: a carrier frame 1; the carrying frame 1 is of a rectangular structure, the left side and the right side of the carrying frame 1 are both provided with a binding belt, and the other ends of the two binding belts are both provided with two fixing belts; the left side and the right side of the inside of the carrying frame 1 are both provided with a sliding chute, two guide rods 2 are arranged inside the two sliding chutes through springs, and the two guide rods 2 are of cylindrical rod-shaped structures; the guide bar 2 includes: the left plate 201 is arranged at the left ends of the two guide rods 2, and the left plate 201 is of a kidney-shaped structure; the right plate 202 is arranged at the right ends of the two guide rods 2, the right plate 202 is of a waist-shaped structure, and the two guide rods 2 slide along the two sliding grooves to drive the main magnetic device 3 to move, so that the up-and-down position of the main magnetic device 3 is adjusted; the guide bar 2 further includes: the two rows of slots 203 are respectively arranged on the front sides of the left plate 201 and the right plate 202 at intervals from top to bottom; inner grooves 204, two inner grooves 204 are symmetrically arranged at the left side of the right plate 202 up and down, and a plurality of suitable insertion rods 503 are inserted into the two rows of slots 203, so that the left plate 201, the right plate 202, the two guide rods 2 and the main magnetic device 3 are fixed; the guide bar 2 further includes: two sliding columns 205, the two sliding columns 205 are respectively installed inside the two inner grooves 204 in a sliding manner, and the two sliding columns 205 are cylindrical columnar structures; a support plate 206, wherein the support plate 206 is arranged in the middle of the right side of the left plate 201, the support plate 206 is of a rectangular structure, and the right side of the support plate 206 is connected with the left side of the right plate 202; the two clamping plates 207 are respectively arranged at the left ends of the two sliding columns 205, a row of clamping grooves are formed in the outer sides of the two clamping plates 207, and the main magnetic devices 3 slide along the guide rods 2, so that the left and right positions of the main magnetic devices 3 are adjusted; the guide bar 2 further includes: the sleeve plate 208 is sleeved and slidably mounted on the support plate 206, and two springs are arranged between the left side of the sleeve plate 208 and the right side of the left plate 201; the two connecting rods 209 are arranged and rotatably mounted on the right side of the sleeve plate 208 in an up-down symmetrical manner, the other ends of the two connecting rods 209 are connected with the left end of one clamping plate 207 through bearings, the sleeve plate 208 is pushed to the right side through springs, so that the two connecting rods 209 are driven to move rightwards, the other ends of the two connecting rods 209 are respectively extended to the upper side and the lower side to support the two clamping plates 207, and the clamping grooves on the two clamping plates 207 are clamped and fixed with the two rows of clamping blocks 304.

As shown in fig. 7 and 8: a main magnetic device 3 is sleeved and slidably mounted on the two guide rods 2, and the main magnetic device 3 is of a rectangular structure; the main magnetic device 3 includes: the front plate 301, the front plate 301 is arranged at the front side of the main magnetic device 3, and the front plate 301 is a rectangular structure; fixing grooves 302, eleven rows of fixing grooves 302 are arranged at equal intervals from left to right on the front side of the front plate 301, and when the powerful magnetic device 402 is moved to a proper position, the fixing rod 403 is selectively inserted into the proper fixing groove 302, so that the position of the powerful magnetic device 402 is positioned; the main magnetic device 3 further includes: the side groove 303, the side groove 303 is opened on the right side of the main magnetic device 3, and the side groove 303 is rectangular; the two rows of blocks 304 and the two rows of blocks 304 are respectively disposed on the upper and lower sides of the side groove 303, and when the main magnetic device 3 moves to a certain position along the two guide rods 2, the two clamping plates 207 and the two rows of blocks 304 are fixed, so that the main magnetic device 3 is kept at the moved position.

As shown in fig. 8 and 9: four corners of the front side of the main magnetic device 3 are respectively provided with a cross arm block 4, and the four cross arm blocks 4 are of a triangular structure; the stretcher 4 comprises: the lantern ring 401 is installed on the inner sides of the four carrying blocks 4 through springs, and the lantern ring 401 is of a circular structure; the strong magnetic equipment 402 is arranged inside the lantern ring 401, and the strong magnetic equipment 402 is moved to drive the magnetic targeting preparation swallowed by a patient to move in a human body, so that the magnetic targeting preparation can be accurately moved to a targeting part; the shoulder block 4 further comprises: the fixing rod 403 is slidably installed on the front side of the powerful magnetic device 402, and the fixing rod 403 is of a cylindrical rod-shaped structure; the baffle disc 404 is arranged at the front end of the fixing rod 403, the baffle disc 404 is of a disc-shaped structure, a spring is arranged in front of the rear side of the baffle disc 404 and the front side of the powerful magnetic device 402, and after the powerful magnetic device 402 drives the magnetic targeting preparation to move to a target position, the baffle disc 404 is pushed towards the rear side through the spring to drive the fixing rod 403 to be inserted into the appropriate fixing groove 302, so that the powerful magnetic device 402 is positioned at an appropriate position, the magnetic targeting preparation in the body of a patient is positioned at the target position, the target position can absorb the preparation conveniently, and the treatment effect of the preparation is improved.

As shown in fig. 3 and 10: the left end and the right end of the front side of the carrying frame 1 are respectively provided with a loading shell 5, the two loading shells 5 are rectangular structures, and the carrying frame 1 is conveniently fixed on the liver of a patient through two binding belts and four fixing belts on the carrying frame 1; the loading case 5 includes: the two threaded rods 501 are respectively arranged on the front sides of the two loading shells 5, and hand wheels are arranged at the front ends of the two threaded rods 501; the two push plates 502 are respectively installed inside the two loading shells 5 in a sliding manner, the two push plates 502 are in a rectangular structure, and the front sides of the two push plates 502 are respectively connected with the rear ends of the two threaded rods 501 in a rotating manner; the two rows of the insertion rods 503 are respectively arranged on the rear sides of the two push plates 502 at intervals from top to bottom, and the two threaded rods 501 are rotated to push the two push plates 502 backwards, so that the two push plates 502 drive the two groups of the insertion rods 503 to move backwards, and the appropriate insertion rods 503 are respectively inserted into the two rows of the slots 203, so that the two guide rods 2 and the main magnetic device 3 are fixed at appropriate positions by the insertion rods 503, and the main magnetic device 3 is convenient to attract and guide the medicine in the human body.

In another embodiment: threaded rod 501 can be replaced by small-size cylinder, pushes away two push plates 502 and two sets of inserted bars 503 to the rear side through small-size cylinder, makes inserted bar 503 insert the inside of two rows of slots 203 to improve the degree of automation of this device, compare in accomplishing the labour saving and time saving more of fixed work through two threaded rods 501 of artifical rotation.

The working principle is as follows: when in use, the carrying frame 1 is fixed on the thorax part of a patient through the matching of the two binding belts and the four fixing belts on the carrying frame 1, so that the carrying frame 1 is positioned at the liver part of the patient, then the two guide rods 2 slide along the two sliding grooves to drive the main magnetic device 3 to move up and down, after the movement is finished, the two threaded rods 501 are rotated to push the two push plates 502 backwards, so that the two push plates 502 drive the two groups of insertion rods 503 to move backwards, so that the proper insertion rods 503 are respectively inserted into the two rows of slots 203, so that the insertion rods 503 fix the two guide rods 2 and the main magnetic device 3 at proper positions, then the main magnetic device 3 slides left and right along the guide rods 2 to adjust the left and right positions of the main magnetic device 3, and then the sleeve plate 208 is pushed to the right side through the spring to drive one end of the two connecting rods 209 to move rightwards, the other ends of the two connecting rods 209 are respectively extended upwards and downwards to two sides to support two clamping plates 207, clamping grooves on the two clamping plates 207 are clamped and fixed with the two rows of clamping blocks 304, so that the two clamping plates 207 limit and fix the main magnetic device 3, the position adjustment work of the main magnetic device 3 is finished, the main magnetic device 3 performs basic attraction and guidance on the preparation in the human body, so that the medicament is attracted to a position close to a target position, then the powerful magnetic device 402 is moved to replace the main magnetic device 3 to drive the magnetic target preparation swallowed by a patient to move in the human body, so that the magnetic target preparation can be accurately moved to the target position, then the baffle disc 404 is pushed backwards through the spring to drive the fixing rod 403 to be inserted into the proper fixing groove 302, so that the powerful magnetic device 402 is positioned at the proper position, and the magnetic target preparation in the patient is positioned at the target position, thereby facilitating the sustained absorption of the preparation by the target part and the treatment of the target part.

It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.

Claims

1. A fixing device for improving the treatment effect of a liver-targeted drug, characterized in that: a fixing device for improving liver targeting medicine treatment effect includes

Carrying a frame;

the left side and the right side of the carrying frame are respectively provided with a binding belt, and the other ends of the two binding belts are respectively provided with two fixing belts; the left side and the right side of the inner part of the carrying frame are both provided with a sliding chute, and two guide rods are arranged in the two sliding chutes through springs;

a main magnetic device is sleeved and slidably mounted on the two guide rods; four corners of the front side of the main magnetic device are respectively provided with a cross arm block; the left end and the right end of the front side of the carrying frame are provided with a carrying shell;

the main magnetic device includes: the front plate is arranged on the front side of the main magnetic equipment; eleven rows of fixing grooves are arranged on the front side of the front plate at equal intervals from left to right; the main magnetic device further includes: the side groove is formed in the right side of the main magnetic equipment; the two rows of fixture blocks are respectively arranged on the upper side and the lower side of the side groove; the stretcher comprises: the lantern ring is arranged on the inner sides of the four cross arm blocks through springs; the strong magnetic equipment is arranged inside the lantern ring; the stretcher block further comprises: the fixed rod is slidably arranged on the front side of the powerful magnetic equipment; and the blocking disc is arranged at the front end of the fixing rod, and a spring is arranged in front of the rear side of the blocking disc and the front side of the strong magnetic equipment.

2. The fixation device for improving the therapeutic effect of a liver-targeted drug according to claim 1, wherein: the guide bar includes:

the left plate is arranged at the left ends of the two guide rods;

and the right plate is arranged at the right ends of the two guide rods.

3. The fixation device for improving the therapeutic effect of a liver-targeted drug according to claim 2, wherein: the guide arm still includes:

the two rows of slots are respectively arranged on the front sides of the left plate and the right plate at equal intervals from top to bottom;

and the two inner grooves are arranged on the left side of the right plate in an up-and-down symmetrical manner.

4. A fixation device for improving the therapeutic effect of a liver-targeted drug according to claim 3, characterized in that: the guide arm still includes:

the two sliding columns are respectively installed inside the two inner grooves in a sliding manner;

the support plate is arranged in the middle of the right side of the left plate, and the right side of the support plate is connected with the left side of the right plate;

the cardboard, two cardboard set up respectively in the left end of two sliding columns, and the outside of two cardboards has all seted up one row of draw-in groove.

5. The fixation device for improving the therapeutic effect of liver-targeted drugs as claimed in claim 4, wherein: the guide arm still includes:

the sleeve plate is sleeved and slidably mounted on the support plate, and two springs are arranged between the left side of the sleeve plate and the right side of the left plate;

and the two connecting rods are arranged and rotatably arranged on the right side of the sleeve plate in an up-down symmetrical manner, and the other ends of the two connecting rods are connected with the left end of one clamping plate through bearings.

6. The fixation device for improving the therapeutic effect of a liver-targeted drug according to claim 1, wherein: the loading shell includes:

the two threaded rods are respectively arranged on the front sides of the two loading shells;

the two push plates are respectively arranged inside the two loading shells in a sliding way, and the front sides of the two push plates are respectively connected with the rear ends of the two threaded rods in a rotating way;

and the two rows of the inserting rods are respectively arranged on the rear sides of the two push plates at intervals from top to bottom at equal intervals.