CN219557656U - Intranasal administration device of target non-human primate nervous system - Google Patents
Intranasal administration device of target non-human primate nervous system Download PDFInfo
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- CN219557656U CN219557656U CN202222992681.7U CN202222992681U CN219557656U CN 219557656 U CN219557656 U CN 219557656U CN 202222992681 U CN202222992681 U CN 202222992681U CN 219557656 U CN219557656 U CN 219557656U
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- intranasal administration
- administration device
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- microinjection
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Abstract
The utility model relates to the technical field of medical instruments, in particular to an intranasal drug delivery device for targeting a nervous system of a non-human primate. An intranasal delivery device for targeting the nervous system of a non-human primate comprising: the device comprises an operation table, a fixed support, a movable fixed support and a microinjection pump, wherein the fixed support is fixed on the operation table, one end of the movable fixed support is detachably connected with the operation table, and the other end of the movable fixed support is detachably connected with the microinjection pump; in this scheme, through the head of fixed bolster fixed animal, combine the fixed microinjection pump of movable fixed bolster and nimble adjustment microinjection pump's position for the accurate nasal cavity of injecting the animal of medicine has reduced the device of dosing and has brought the risk of losing for the animal, and has adopted microinjection pump to replace traditional manual dosing, can control the speed that the medicine dripped into in the nasal cavity accurately, makes the medicine drip into in the animal nasal cavity slowly at the uniform velocity, thereby improves the absorption efficiency of medicine.
Description
Technical Field
The utility model relates to the technical field of medical instruments, in particular to an intranasal drug delivery device for targeting a nervous system of a non-human primate.
Background
As the prevalence of neurological disorders increases year by year, and the lack of effective or powerful therapies for neurological disorders places a tremendous and ever increasing burden on healthcare systems and society, treatment of neurological disorders is receiving increasing attention.
In order to avoid the influence of the high selectivity of the blood brain barrier on the treatment of the nervous system diseases, the current treatment of the nervous system diseases generally adopts intranasal administration, and directly enters brain tissues and other nervous systems through the blood brain barrier so as to realize the aim of drug treatment. However, in the prior art, for the intranasal administration device of the non-human primate, manual administration is generally performed by adopting a handheld administration device, and the speed of dripping the medicine into the nasal cavity cannot be accurately controlled, so that the absorption efficiency of the medicine is low.
Disclosure of Invention
The embodiment of the utility model discloses an intranasal administration device of a target non-human primate nervous system, which can accurately control the speed of medicine dripping into a nasal cavity and improve the absorption efficiency of medicine.
The embodiment of the utility model provides an intranasal administration device for targeting a nervous system of a non-human primate, which comprises the following components: the device comprises an operation table, a fixed support, a movable fixed support and a microinjection pump;
the fixed bracket is fixed on the operation table;
one end of the movable fixing support is detachably connected with the operating platform, and the other end of the movable fixing support is detachably connected with the microinjection pump.
Preferably, the microinjection pump includes: an electronic console, a microinjection arm, a syringe and a needle;
the microinjection arm is connected with the electronic control console, and the injector is arranged in the microinjection arm;
the needle is connected with a medicine inlet and a medicine outlet of the injector.
Preferably, the syringe is a single use sterile syringe and the needle is a single use sterile needle.
Preferably, the needle is a plastic needle.
Preferably, the movable fixing bracket includes: a stationary clip and a movable arm;
the fixed clamp is fixedly connected with the movable arm.
Preferably, the movable arm is a mechanical arm with telescopic and rotary functions.
Preferably, the movable arm is made of carbon steel.
Preferably, the fixing support is symmetrically provided with two ear rods, and the ear rods are used for fixing two sides of the head.
Preferably, the fixing support is concave, and the opening direction of the fixing support faces the head direction.
Preferably, the operation table is provided with four table legs, and the four table legs are uniformly distributed, so that the table top of the operation table is horizontal.
From the above technical solutions, the embodiment of the present utility model has the following advantages:
the present utility model provides an intranasal administration device targeting the nervous system of a non-human primate comprising: the device comprises an operation table, a fixed support, a movable fixed support and a microinjection pump; the fixed bracket is fixed on the operation table; one end of the movable fixing support is detachably connected with the operating platform, and the other end of the movable fixing support is detachably connected with the microinjection pump.
According to the scheme, the head of the non-human primate is fixed through the fixed support, the microinjection pump is fixed through the movable fixed support, and the position of the microinjection pump is flexibly adjusted, so that the medicine is accurately injected into the nasal cavity of the animal, the risk of damage to the animal caused by the medicine feeding device is reduced, the microinjection pump is adopted to replace the traditional manual medicine feeding, the speed of dropping the medicine into the nasal cavity can be accurately controlled, the medicine is slowly dropped into the nasal cavity of the animal at a uniform speed, and the medicine absorption efficiency is improved.
Drawings
In order to more clearly illustrate the embodiments of the utility model or the technical solutions of the prior art, the drawings which are used in the description of the embodiments or the prior art will be briefly described, it being obvious that the drawings in the description below are only some embodiments of the utility model, and that other drawings can be obtained from these drawings without inventive faculty for a person skilled in the art.
Fig. 1 is a schematic structural diagram of an intranasal administration device for targeting the nervous system of a non-human primate according to an embodiment of the present utility model.
In the figure, 1 is an operation table, 2 is a fixed support, 21 is a first ear rod, 22 is a second ear rod, 3 is a movable fixed support, 4 is a microinjection pump, 40 is an electronic control table, 41 is a microinjection arm, 42 is a syringe, 43 is a needle, and 5 is a medicine.
Detailed Description
With the approval of this novel route of administration in clinical trials, it would be important to optimize the devices and methods of intranasal administration in order to meet the increasing therapeutic demands of patients with neurological diseases. At present, most of researches adopt a hand-held medicine feeder for manual medicine feeding, which can not only accurately control the speed of medicine dripping into the nasal cavity, but also easily damage the nasal cavity, and the absorption efficiency of the medicine is greatly affected.
In view of the above, the present utility model provides an intranasal administration device for targeting the nervous system of a non-human primate, which can reduce the risk of injury to the animal caused by the administration device, and can precisely control the speed of dropping the drug into the nasal cavity, thereby improving the absorption efficiency of the drug.
The following description of the embodiments of the present utility model will be made apparent and fully in view of the accompanying drawings, in which some, but not all embodiments of the utility model are shown. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.
In the description of the present utility model, it should be noted that the directions or positional relationships indicated by the terms "front", "rear", "upper", "lower", "both ends", "center", "horizontal", "inner", "outer", etc. are based on the directions or positional relationships shown in the drawings, are merely for convenience of describing the present utility model and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a specific orientation, be configured and operated in a specific orientation, and thus should not be construed as limiting the present utility model. Relational terms such as "first," "second," and the like may be used solely to distinguish one entity from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities.
Unless specifically stated or limited otherwise, the terms "mounted," "connected," "secured," "disposed" and "fixed" are to be construed broadly, as they may be, for example, fixedly connected, detachably connected, or integrally connected; the two components can be mechanically connected, can be directly connected or can be indirectly connected through an intermediate medium, and can be communicated with each other. The specific meaning of the above terms in the present utility model will be understood in specific cases by those of ordinary skill in the art.
Referring to fig. 1, an intranasal administration device for targeting a nervous system of a non-human primate according to the present embodiment comprises: a console 1, a fixed support 2, a movable fixed support 3 and a microinjection pump 4. Wherein, operation panel 1 is used for placing various devices and medicine reagent to and provide a position of lying for non-human primate, and fixed bolster 2 is fixed in on operation panel 1 for fixed non-human primate's head, avoid the animal to use medicine device to harm animal nasal cavity when taking medicine head rotation, microinjection pump 4 can control the speed of dosing and carry out automatic dosing. One end of the movable fixing support 3 is detachably connected with the operation table 1, and the other end of the movable fixing support 3 is detachably connected with the microinjection pump 4, so that the microinjection pump 4 is fixed on the fixing table, and the position can be adjusted through the movable fixing support, thereby facilitating the administration of medicines to animals and avoiding damage to the nasal cavities of the animals due to long-time handheld shaking.
It will be appreciated that the microinjection pump is secured around the fixed support by a movable support so that the microinjection pump is closer to the animal's head for ease of operation.
According to the embodiment, the head of an animal is fixed through the fixed support, the head of the animal is prevented from being damaged due to rotation of the head of the animal, the microinjection pump is fixed through the movable fixed support, the position of the microinjection pump is flexibly adjusted, the medicine is accurately injected into the nasal cavity of the animal, damage to the nasal cavity of the animal due to long-time handheld shaking is avoided, further, the risk of damage to the animal caused by the medicine feeding device is reduced, the microinjection pump is adopted to replace traditional manual medicine feeding, the speed of dropping the medicine into the nasal cavity can be accurately controlled, the medicine is slowly dropped into the nasal cavity of the animal at a uniform speed, and therefore the absorption efficiency of the medicine is improved.
In a specific embodiment, microinjection pump 4 comprises: an electronic control console 40, a microinjection arm 41, a syringe 42 and a needle 43, wherein the microinjection arm 41 is connected with the electronic control console 40, and the syringe 42 is installed in the microinjection arm 41. It will be appreciated that the movable fixed support 3 is detachably connected to the microinjection arm 41 of the microinjection pump 4, so that the position of the syringe can be adjusted at will, and the microinjection arm can be connected to the electronic control console by a circuit or by a communication connection. Specifically, the communication connection is a wired connection or a wireless connection. In a specific embodiment, the microinjection arm is in wireless connection with the electronic control console, and when a plurality of drug administration personnel are required to cooperatively operate in the drug administration process to adjust the drug administration speed and the type of the used drugs, the personnel operating the electronic control console can be far away from the operation console, so that the influence on the personnel of the personnel is avoided. In another embodiment, the microinjection arm is connected with the electronic control console in a wired mode, when the medicine taking speed is stable in the whole medicine taking process, the medicine taking type is single, the whole medicine taking process can be finished by only one medicine taking person, and the manufacturing cost of the device can be reduced by selecting the wired connection.
As a further improvement, the syringe 42 is a disposable sterile syringe, and the needle 43 is a disposable sterile needle, so that the replacement is convenient, and cross contamination is avoided.
As a further improvement, the needle 43 is a plastic needle, and the plastic needle can further avoid damage to the nasal cavity.
As a further improvement, the movable fixing bracket 3 includes: the fixed clamp and the movable arm are fixedly connected and detachably connected with the operation table 1. The movable arm can be arbitrarily adjusted in angle and telescopic distance to ensure that the microinjection arm can accurately extend into the nasal cavity of the animal. It will be appreciated that the retaining clip may be secured by clamping the edge of the console.
In a specific embodiment, the moveable arm may be a telescopic and rotatable mechanical arm.
In another specific embodiment, the moveable arm is made of a material that can be bent freely a plurality of times, which may be selected from, but is not limited to, carbon steel.
As a further improvement, the fixing support 3 is provided with a first ear rod 21 and a second ear rod 22, the first ear rod 21 and the second ear rod 22 are symmetrically arranged on the fixing table, the two ear rods are slidably connected with the fixing table, and the ear rods are used for being fixed on two sides of the head. Two ear rods are fixed at the two side ear bones of the head, so as to achieve the effect of fixing the head and prevent nasal cavity injury caused by head shaking in the intranasal administration process.
As a further improvement, the fixing support 3 is in a U shape or a concave shape, and the opening direction of the fixing support 3 faces the head direction, so that the fixing support is more consistent with the head shape and is more stable to fix.
As a further improvement, the operation table 1 is provided with four table legs which are uniformly distributed, so that the table top of the operation table is horizontal, and the administration of administration staff is facilitated.
In a specific embodiment, the non-human primate intranasal administration device is for a test monkey, wherein the operating platform is a rectangular table of 150cm length, 100cm width and 80cm height for placement of anesthetized animals and microinjection pumps and various intranasal administration equipment and medicines, all of which are performed on the operating platform, ensuring sufficient operating space. The table comprises four table legs and a cuboid table top, and is made of stainless steel materials, so that the table is stably placed and cannot shake.
As a further improvement, a pillow can be arranged on the operation table 1 at the opening of the fixed support 3, and the head of the animal is in an inclined state with the head top low and the lower back high through the pillow, so that the administration is convenient.
Furthermore, the present embodiment also provides a use procedure of the intranasal administration device for targeting the monkey nervous system of a non-human primate as follows:
the table top of the operation table 1 is adjusted to be in a horizontal state, so that animals lie on the operation table 1 and the hericium erinaceus are fixed through the fixing support. The drug administration personnel uses a disposable sterile injector and a disposable sterile needle to absorb the drug 5 and then is connected with the microinjection arm 41, so that the injector 42 is fixed on the microinjection arm 41, the microinjection arm 41 is connected and fixed with the movable bracket 3 after the connection and fixation are carried out, and after the movable bracket 3 is fixed, the angle and the position of the movable bracket 3 are adjusted to enable the disposable sterile injector needle 43 to be aligned with the nasal cavity of the test monkey and slowly extend into the half depth of the nasal cavity. After the depth and the fixed position are adjusted, an electronic control console 4 of the microinjection pump is operated, the administration speed is set on the electronic control console, and the on-off key is started to perform nasal instillation slowly at a constant speed.
In actual use of the present embodiment, the medicine 5 includes: hyaluronidase and a medicament for treating a neurological disease, wherein hyaluronidase is an enzyme capable of reducing the activity of hyaluronic acid in vivo, thereby improving the liquid permeability in tissues. Before the formal intranasal administration, a proper amount of hyaluronidase is administrated intranasally to improve the permeability of nasal mucosa, thereby improving the absorption efficiency of the medicine.
While the present utility model has been described in detail with respect to an intranasal administration device for targeting the nervous system of a non-human primate, those skilled in the art will recognize that the scope of the present utility model is not limited to the specific embodiments and applications described above, based on the ideas of the embodiments of the present utility model.
Claims (10)
1. An intranasal administration device for targeting the nervous system of a non-human primate comprising: the device comprises an operation table, a fixed support, a movable fixed support and a microinjection pump;
the fixed bracket is fixed on the operation table;
one end of the movable fixing support is detachably connected with the operating platform, and the other end of the movable fixing support is detachably connected with the microinjection pump.
2. The intranasal administration device of claim 1, wherein the microinjection pump comprises: an electronic console, a microinjection arm, a syringe and a needle;
the microinjection arm is connected with the electronic control console, and the injector is arranged in the microinjection arm;
the needle is connected with a medicine inlet and a medicine outlet of the injector.
3. The intranasal administration device of claim 2, wherein the syringe is a single use sterile syringe and the needle is a single use sterile needle.
4. An intranasal administration device as claimed in claim 2 or claim 3 wherein the needle is a plastics needle.
5. The intranasal administration device of claim 1, wherein the movable fixed mount comprises: a stationary clip and a movable arm;
the fixed clamp is fixedly connected with the movable arm.
6. The intranasal administration device of claim 5, wherein the moveable arm is a robotic arm having telescoping and rotating functions.
7. The intranasal administration device of claim 5, wherein the moveable arm is carbon steel.
8. The intranasal administration device of claim 1, wherein two ear stems are symmetrically disposed on the fixing support, the ear stems being for fixing both sides of the head.
9. The intranasal administration device of claim 1, wherein the fixing stent is "concave" and the fixing stent is open toward the head.
10. The intranasal administration device of claim 1 wherein the console is provided with four legs that are evenly distributed such that the top of the console is level.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202222992681.7U CN219557656U (en) | 2022-11-10 | 2022-11-10 | Intranasal administration device of target non-human primate nervous system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202222992681.7U CN219557656U (en) | 2022-11-10 | 2022-11-10 | Intranasal administration device of target non-human primate nervous system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN219557656U true CN219557656U (en) | 2023-08-22 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202222992681.7U Active CN219557656U (en) | 2022-11-10 | 2022-11-10 | Intranasal administration device of target non-human primate nervous system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN219557656U (en) |
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2022
- 2022-11-10 CN CN202222992681.7U patent/CN219557656U/en active Active
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