CN113558745A - 一种用于治疗肺动脉高压的脉冲消融导管 - Google Patents

一种用于治疗肺动脉高压的脉冲消融导管 Download PDF

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CN113558745A
CN113558745A CN202110919334.9A CN202110919334A CN113558745A CN 113558745 A CN113558745 A CN 113558745A CN 202110919334 A CN202110919334 A CN 202110919334A CN 113558745 A CN113558745 A CN 113558745A
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pulse
ablation
ablation catheter
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戴海龙
荆志成
韩志岩
光雪峰
周旭
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Yanan Hospital of Kunming City
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Abstract

本发明公开一种用于治疗肺动脉高压的脉冲消融导管，包括消融导管和能量平台，消融导管包括活动外鞘管、消融导管、功能导芯、脉冲消融部和操作部，通过操作部控制脉冲消融部在消融导管中心的功能导芯轴向滑动，同时控制脉冲消融部的中间的条状拱起在周向拱起或收拢，进而通过脉冲电极片和能量平台进行脉冲消融；本发明的用于治疗肺动脉高压的脉冲消融导管，通过频率和消融端形状可控的脉冲消融导管进行脉冲消融，治疗肺动脉高压。

Description

一种用于治疗肺动脉高压的脉冲消融导管
技术领域
本发明涉及医疗器械技术领域，具体的涉及一种用于治疗肺动脉高压的脉冲消融导管。
背景技术
肺动脉高压是一类主要累及肺小动脉的血管病变，肺动脉压力进行性升高，导致患者心肺循环血流动力学改变、肺动脉血管重构、右心肥大、功能衰竭为其主要特征。肺动脉高压诊断的金标准为海平面状态下、静息时右心导管测量平均肺动脉压≥25mmHg，同时肺小动脉楔压≤15mmHg及肺血管阻力>3Wood单位。实验数据证明肺动脉高压与肺动脉周围交感神经兴奋性增高及肺动脉压力感受器异常活跃有关，阻断肺动脉周围交感神经或永久性破坏压力感受器的结构及其功能能够使肺动脉压下降，将成为治疗肺动脉高压的突破性技术。
脉冲电场消融是指在短时间内将高电压电脉冲作用于细胞膜的磷脂双分子层，导致跨膜电位形成，从而产生不稳定的电势，使细胞膜形成不可逆的穿透性损伤，产生纳米级的孔隙，从而导致细胞膜渗透率的变化，破坏细胞内环境稳态，最终导致细胞凋亡。
脉冲电场消融具有以下特点：(1)脉冲电场消融可保留细胞外基质。基于热传导的消融技术依赖于凝固性坏死，并且将凝固性坏死一直延伸到细胞致死温度。冷冻消融虽然可使细胞外基质免于直接消融，但其对于细胞的破坏无选择性，可对靶血管的结构产生影响。但脉冲电场消融在其消融区域内可保持组织基质的完整性，避免冠状动脉、膈神经等邻近组织受损伤。(2)消融阈值具有组织特异性，从而可特异性消融某些特定组织(比如心肌、肺动脉)。心肌组织的消融阈值低于许多其他组织，在消融心肌细胞的同时可避免临近组织(食管或膈神经等)受到损伤。(3)与传统射频消融方式相比较，脉冲电场消融不需要依赖导管贴靠力便能造成广泛的心肌损伤。(4)脉冲电场消融速度极快，常以毫秒为单位甚至更小。综上，脉冲电场消融可能更加安全有效，且大大缩短手术时间。
目前，针对肺动脉高压的治疗，还停留在射频消融或冷冻消融进行治疗，没有针对肺动脉高压治疗的脉冲消融导管，使得肺动脉高压治疗还存在局限。
发明内容
针对现有技术存在的上述问题，本发明提供了一种用于治疗肺动脉高压的脉冲消融导管，通过频率和消融端形状可控的脉冲消融导管进行脉冲消融，治疗肺动脉高压。
为实现上述技术目的，达到上述技术效果，本发明是通过以下技术方案实现：
一种用于治疗肺动脉高压的脉冲消融导管，包括消融导管和能量平台，所述消融导管包括活动外鞘管、消融导管、功能导芯、脉冲消融部和操作部，所述活动外鞘管在消融导管外轴向活动，通过后端的操作部控制消融导管的脉冲消融部的位置和形态，脉冲消融部的形态为贴合消融导管或拱起形成镂空的球状，通过连接能量平台进行脉冲消融。
进一步的，所述消融导管上活动连接活动外鞘管，活动外鞘管后端为操作部，所述消融导管内为功能导芯，所述脉冲消融部的前端为活动端受操作部控制在消融导管中心的功能导芯轴向滑动，脉冲消融部的中间为若干可向周向拱起的条状拱起；
进一步的，所述脉冲消融部前端的操作部与功能导丝固定。
进一步的，所述条状拱起上设置间隔包裹条状拱起的脉冲电极片，所述脉冲电极由功能导芯后端连接的能量平台提供能量，所述脉冲消融部的末端与消融导管一体。
进一步的，所述能量平台与消融导管连接，能量平台包括主机、显示端以及调节端。
进一步的，所述功能内芯为中空内芯供内部的引导导丝通过，同时还可以用于肺动脉压力监测。
本发明的有益效果：
本发明的用于治疗肺动脉高压的脉冲消融导管，包括消融导管和能量平台，消融导管包括活动外鞘管、消融导管、功能导芯、脉冲消融部和操作部，通过操作部控制脉冲消融部在消融导管中心的功能导芯轴向滑动，同时控制脉冲消融部的中间的条状拱起在周向拱起或收拢，进而通过脉冲电极片和能量平台进行脉冲消融；
本发明的用于治疗肺动脉高压的脉冲消融导管，通过频率和消融端形状可控的脉冲消融导管进行脉冲消融，治疗肺动脉高压。
当然，实施本发明的任一产品并不一定需要同时达到以上所述的所有优点。
附图说明
为了更清楚地说明本发明实施例的技术方案，下面将对实施例描述所需要使用的附图作简单地介绍，显而易见地，下面描述中的附图仅仅是本发明的一些实施例，对于本领域普通技术人员来讲，在不付出创造性劳动的前提下，还可以根据这些附图获得其他的附图。
图1为本发明实施例所述用于治疗肺动脉高压的脉冲消融导管的结构示意图；
图2为本发明实施例所述消融导管的结构示意图；
附图中，各标号代表的部件如下：
1-消融导管，101-活动外鞘管，102-消融导管，103-功能内芯，104-活动端，105-条状拱起，106-脉冲电极片，107-操作部，2-能量平台。
具体实施方式
下面将结合本发明实施例中的附图，对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有作出创造性劳动前提下所获得的所有其它实施例，都属于本发明保护的范围。
实施例1
如图1-2所示
一种用于治疗肺动脉高压的脉冲消融导管，包括消融导管1和能量平台2，所述消融导管1包括活动外鞘管101、消融导管102、功能导芯103、脉冲消融部和操作部107，所述活动外鞘管101在消融导管102外轴向活动，通过后端的操作部107控制消融导管102的脉冲消融部的位置和形态，脉冲消融部的形态为贴合消融导管102或拱起形成镂空的球状，通过连接能量平台2进行脉冲消融。
所述消融导管102上活动连接活动外鞘管101，活动外鞘管101后端为操作部107，所述消融导管102内为功能导芯103，所述脉冲消融部的前端为活动端104受操作部107控制在消融导管中心的功能导芯103轴向滑动，脉冲消融部的中间为若干可向周向拱起的条状拱起105；
所述脉冲消融部前端的操作部107与功能导丝固定。
所述条状拱起105上设置间隔包裹条状拱起的脉冲电极片106，所述脉冲电极片106由功能导芯103后端连接的能量平2台提供能量，所述脉冲消融部的末端与消融导管102一体。
所述能量平台2与消融导管102连接，能量平台2包括主机、显示端以及调节端。
所述功能内芯103为中空内芯供内部的引导导丝通过。
实施例2
用于治疗肺动脉高压的脉冲消融导管的操作方法；
如上述实施例1所述的用于治疗肺动脉高压的脉冲消融导管，消融导管后端与能量平台连接；
通过引导导丝的引导，将功能导芯、消融导管和活动外鞘管输送至相应的位置，到达相应位置后，将活动外鞘管向后活动，漏出消融导管的脉冲消融部，通过操作端控制功能导芯，向后拉动，由于功能导芯的前端与脉冲消融部为固定，而脉冲消融部的后端与消融导管为一体，使得脉冲消融部的条状拱起形成镂空的球状，之后固定功能导芯，保持条状拱起为镂空的球状，并到达指定位置进行脉冲消融；
消融完成后，通过操作端将脉冲消融部回撤，并通过功能导芯将拱起为镂空球状的条状拱起收拢，使其形态为贴合消融导管并退出。
实施例3
本发明的用于治疗肺动脉高压的脉冲消融导管，包括消融导管和能量平台，消融导管包括活动外鞘管、消融导管、功能导芯、脉冲消融部和操作部，通过操作部控制脉冲消融部在消融导管中心的功能导芯轴向滑动，同时控制脉冲消融部的中间的条状拱起在周向拱起或收拢，进而通过脉冲电极片和能量平台进行脉冲消融；
本发明的用于治疗肺动脉高压的脉冲消融导管，通过频率和消融端形状可控的脉冲消融导管进行脉冲消融，治疗肺动脉高压。
以上公开的本发明优选实施例只是用于帮助阐述本发明。优选实施例并没有详尽叙述所有的细节，也不限制该发明仅为所述的具体实施方式。显然，根据本说明书的内容，可作很多的修改和变化。本说明书选取并具体描述这些实施例，是为了更好地解释本发明的原理和实际应用，从而使所属技术领域技术人员能很好地理解和利用本发明。本发明仅受权利要求书及其全部范围和等效物的限制。

Claims (6)

1.一种用于治疗肺动脉高压的脉冲消融导管，其特征在于：包括消融导管和能量平台，所述消融导管包括活动外鞘管、消融导管、功能导芯、脉冲消融部和操作部，所述活动外鞘管在消融导管外轴向活动，通过后端的操作部控制消融导管的脉冲消融部的位置和形态，脉冲消融部的形态为贴合消融导管或拱起形成镂空的球状，通过连接能量平台进行脉冲消融。
2.如权利要求1所述的用于治疗肺动脉高压的脉冲消融导管，其特征在于：所述消融导管上活动连接活动外鞘管，活动外鞘管后端为操作部，所述消融导管内为功能导芯，所述脉冲消融部的前端为活动端受操作部控制在消融导管中心的功能导芯轴向滑动，脉冲消融部的中间为若干可向周向拱起的条状拱起。
3.如权利要求2所述的用于治疗肺动脉高压的脉冲消融导管，其特征在于：所述脉冲消融部前端的操作部与功能导丝固定。
4.如权利要求2所述的用于治疗肺动脉高压的脉冲消融导管，其特征在于：所述条状拱起上设置间隔包裹条状拱起的脉冲电极片，所述脉冲电极由功能导芯后端连接的能量平台提供能量，所述脉冲消融部的末端与消融导管一体。
5.如权利要求1所述的用于治疗肺动脉高压的脉冲消融导管，其特征在于：所述能量平台与消融导管连接，能量平台包括主机、显示端以及调节端。
6.如权利要求1所述的用于治疗肺动脉高压的脉冲消融导管，其特征在于：所述功能内芯为中空内芯供内部的引导导丝通过，同时还可以用于肺动脉压力监测。
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