CN113538614B - Method, device, computer equipment and storage medium for outputting coincidence data - Google Patents

Method, device, computer equipment and storage medium for outputting coincidence data Download PDF

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CN113538614B
CN113538614B CN202110713880.7A CN202110713880A CN113538614B CN 113538614 B CN113538614 B CN 113538614B CN 202110713880 A CN202110713880 A CN 202110713880A CN 113538614 B CN113538614 B CN 113538614B
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response
coincidence
photon
region
interest
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CN113538614A (en
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李俊
郑威
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Shanghai United Imaging Healthcare Co Ltd
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Shanghai United Imaging Healthcare Co Ltd
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Priority to CN202110713880.7A priority Critical patent/CN113538614B/en
Publication of CN113538614A publication Critical patent/CN113538614A/en
Priority to PCT/CN2021/143420 priority patent/WO2022247283A1/en
Priority to EP21942846.3A priority patent/EP4327239A1/en
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    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T11/002D [Two Dimensional] image generation
    • G06T11/003Reconstruction from projections, e.g. tomography
    • G06T11/005Specific pre-processing for tomographic reconstruction, e.g. calibration, source positioning, rebinning, scatter correction, retrospective gating

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  • General Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
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  • Measurement Of Radiation (AREA)

Abstract

The application relates to a method, a device, computer equipment and a storage medium for outputting coincidence data. The method comprises the following steps: determining a plurality of coincidence events and first response lines corresponding to the coincidence events according to photon information captured by the detection component; acquiring a region of interest selected by a user, and screening a plurality of second response lines passing through the region of interest from a plurality of first response lines; screening photon pairs from a plurality of the second response lines to generate target response lines with positions in the region of interest; and outputting the coincidence data corresponding to the target response line. By adopting the method, redundant data can be removed, the image reconstruction time can be shortened, and the data storage pressure can be reduced.

Description

Method, device, computer equipment and storage medium for outputting coincidence data
Technical Field
The present invention relates to the field of coincidence data technologies, and in particular, to a method, an apparatus, a computer device, and a storage medium for outputting coincidence data.
Background
With the development of PET (Positron Emission Computed Tomography positron emission computed tomography) technology and semiconductor technology, the structure of a detection device in a PET system is finer, the number of readout channels of the detection device is increased, and the data volume of output coincidence data is increased.
While an increase in the amount of data that corresponds to the data is beneficial to improving the imaging quality, a large amount of redundant data is also present, which not only increases the image reconstruction time, but also increases the data storage pressure, resulting in disk space tension.
Disclosure of Invention
In view of the foregoing, it is desirable to provide a data-compliant output method, apparatus, computer device, and storage medium capable of reducing redundant data, shortening image reconstruction time, and reducing data storage pressure.
The method for outputting the coincidence data is applied to a coincidence processing component, and the coincidence processing component is connected with a detection component, and comprises the following steps:
determining a plurality of coincidence events and first response lines corresponding to the coincidence events according to photon information captured by the detection component;
acquiring an interested region selected by a user, and screening a plurality of second response lines penetrating through the interested region from a plurality of first response lines;
screening out target response lines with photon pairs in the interested region from the second response lines;
and outputting the coincidence data corresponding to the target response line.
In one embodiment, the acquiring the region of interest selected by the user includes:
Setting an interface in the display area; the display area corresponding to the actual detection area of the detection component is arranged in the area setting interface;
receiving a user selected region based on a region setting interface; the user selection area is located within the display area.
In one embodiment, the selecting a plurality of second lines from the plurality of first lines through the region of interest includes:
mapping the user selected region according to a pre-established mapping relation to obtain a region of interest; the region of interest is located within an actual detection region of the detection component;
if at least one point on the first response line is located within the region of interest, the first response line is determined to be the second response line.
In one embodiment, the detecting component comprises a plurality of detectors, and each two detectors form a detector pair; the coincidence processing component comprises a plurality of sub-coincidence processing components, and each sub-coincidence processing component is connected with one detector pair; the determining a plurality of coincidence events and a first response line corresponding to each coincidence event according to photon information captured by the detecting component includes:
determining the flight time difference of the photon pair according to the photon information captured by the corresponding detector pair for each sub coincidence processing component;
Determining whether an event generating the photon pair is a coincidence event according to the flight time difference of the photon pair and a preset window width;
if the event generating the photon pair is determined to be a coincidence event, a first response line is determined according to the position of the detector pair corresponding to the coincidence event.
In one embodiment, the detector pair includes a first detector and a second detector, and determining a time difference of flight of the photon pair according to the captured photon information of the corresponding detector pair includes:
determining a first flight time and a second flight time according to photon information captured by the first detector and the second detector respectively; wherein the first time of flight is the time from generation of one photon to capture by the first detector and the second time of flight is the time from generation of another photon to capture by the second detector;
and calculating the absolute value of the difference value between the first flight time and the second flight time to obtain the flight time difference of the photon pair.
In one embodiment, determining whether the event generating the photon pair is a coincidence event according to the time difference of flight of the photon pair and the preset window width includes:
judging whether the flight time difference of the photon pair is smaller than a preset window width or not;
if the time-of-flight difference is less than the preset window width, determining the event generating the photon pair as a coincidence event.
In one embodiment, the selecting the target response line with the photon pair generation position located in the region of interest from the plurality of second response lines includes:
determining photon pair generation positions corresponding to the second response lines;
and if the photon pair generation position corresponding to the second response line is positioned in the region of interest, determining the second response line as a target response line.
In one embodiment, the determining the photon pair generating position corresponding to each second response line includes:
determining the distance between two detectors corresponding to the second response lines, the first flight time and the second flight time according to the second response lines;
and calculating the photon pair generation position corresponding to the second response line according to the distance between the two detectors, the first flight time and the second flight time.
In one embodiment, the outputting the coincidence data corresponding to the target response line includes:
screening target sub-coincidence processing components from the plurality of sub-coincidence processing components according to the target response line;
the control target sub-coincidence processing section outputs coincidence data.
An output device for conforming data, the device comprising:
the event determining module is used for determining a plurality of coincidence events and first response lines corresponding to the coincidence events according to the photon information captured by the detecting component;
The first screening module is used for acquiring the region of interest selected by the user and screening a plurality of second response lines penetrating through the region of interest from a plurality of first response lines;
the second screening module is used for screening out target response lines of photon pairs, the generation positions of which are located in the region of interest, from the plurality of second response lines;
and the data output module is used for outputting the coincidence data corresponding to the target response line.
In one embodiment, the first screening module is specifically configured to display an area setting interface; the display area corresponding to the actual detection area of the detection component is arranged in the area setting interface; receiving a user selected region based on a region setting interface; the user selection area is located within the display area.
In one embodiment, the first filtering module is specifically configured to map a user selected area according to a pre-established mapping relationship to obtain an area of interest; the region of interest is located within an actual detection region of the detection component; if at least one point on the first response line is located within the region of interest, the first response line is determined to be the second response line.
In one embodiment, the detecting component comprises a plurality of detectors, and each two detectors form a detector pair; the coincidence processing component comprises a plurality of sub-coincidence processing components, and each sub-coincidence processing component is connected with one detector pair; the event determination module includes:
The time difference determining submodule is used for determining the flight time difference of the photon pairs according to the photon information captured by the corresponding detector pairs aiming at each sub coincidence processing component;
the event determination submodule is used for determining whether an event generating the photon pair is a coincidence event according to the flight time difference of the photon pair and a preset window width;
and the response line determination submodule is used for determining a first response line according to the position of the detector pair corresponding to the coincidence event if the event generating the photon pair is determined to be the coincidence event.
In one embodiment, the detector pair includes a first detector and a second detector, and the time difference determining submodule is specifically configured to determine a first time of flight and a second time of flight according to photon information captured by the first detector and the second detector, respectively; wherein the first time of flight is the time from generation of one photon to capture by the first detector and the second time of flight is the time from generation of another photon to capture by the second detector; and calculating the absolute value of the difference value between the first flight time and the second flight time to obtain the flight time difference of the photon pair.
In one embodiment, the event determination submodule is specifically configured to determine whether a time difference of flight of the photon pair is smaller than a preset window width; if the time-of-flight difference is less than the preset window width, determining the event generating the photon pair as a coincidence event.
In one embodiment, the second screening module includes:
the position determining submodule is used for determining photon pair generation positions corresponding to the second response lines;
and the screening sub-module is used for determining the second response line as a target response line if the photon pair generation position corresponding to the second response line is positioned in the region of interest.
In one embodiment, the location determining submodule is specifically configured to determine, for each second response line, a distance between two detectors corresponding to the second response line, a first flight time, and a second flight time; and calculating the photon pair generation position corresponding to the second response line according to the distance between the two detectors, the first flight time and the second flight time.
In one embodiment, the data output module is specifically configured to screen out a target sub-coincidence processing component from a plurality of sub-coincidence processing components according to a target response line; the control target sub-coincidence processing section outputs coincidence data.
A computer device comprising a memory storing a computer program and a processor which when executing the computer program performs the steps of:
Determining a plurality of coincidence events and first response lines corresponding to the coincidence events according to photon information captured by the detection component;
acquiring an interested region selected by a user, and screening a plurality of second response lines penetrating through the interested region from a plurality of first response lines;
screening out target response lines with photon pairs in the interested region from the second response lines;
and outputting the coincidence data corresponding to the target response line.
A computer readable storage medium having stored thereon a computer program which when executed by a processor performs the steps of:
determining a plurality of coincidence events and first response lines corresponding to the coincidence events according to photon information captured by the detection component;
acquiring an interested region selected by a user, and screening a plurality of second response lines penetrating through the interested region from a plurality of first response lines;
screening out target response lines with photon pairs in the interested region from the second response lines;
and outputting the coincidence data corresponding to the target response line.
The method, the device, the computer equipment and the storage medium for outputting the coincidence data determine a plurality of coincidence events and first response lines corresponding to the coincidence events according to photon information captured by the detection component; acquiring an interested region selected by a user, and screening a plurality of second response lines penetrating through the interested region from a plurality of first response lines; screening out target response lines with photon pairs in the interested region from the second response lines; and outputting the coincidence data corresponding to the target response line. According to the embodiment of the disclosure, the first response line corresponding to the coincidence event is screened twice according to the region of interest, redundant data irrelevant to the region of interest is removed, and because the redundant data is reduced, the image reconstruction time can be shortened, the data storage pressure is reduced, and therefore the disk space tension is avoided.
Drawings
FIG. 1 is an application environment diagram of a method of outputting conforming data in one embodiment;
FIG. 2 is a flow chart illustrating a method of outputting conforming data in one embodiment;
FIG. 3a is a schematic diagram of a detector in one embodiment;
FIG. 3b is a schematic diagram of a second embodiment of a detector;
FIG. 4 is a schematic diagram of the connection between a coincidence processing component and a detection component in one embodiment;
FIG. 5 is a flow diagram of a process for determining a coincidence event and a first line of response in one embodiment;
FIG. 6 is a flowchart illustrating a second line-of-response screening step according to one embodiment;
FIG. 7 is a flowchart illustrating a step of selecting a target line of response in one embodiment;
FIG. 8 is a flow chart illustrating the step of outputting the conforming data in one embodiment;
FIG. 9 is a block diagram of a data compliant output device in one embodiment;
fig. 10 is an internal structural view of a computer device in one embodiment.
Detailed Description
In order to make the objects, technical solutions and advantages of the present application more apparent, the present application will be further described in detail with reference to the accompanying drawings and examples. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the present application.
The method for outputting the coincidence data can be applied to an application environment shown in fig. 1. The application environment includes a coincidence processing component 102 and a detection component 104; wherein the coincidence processing component 102 is coupled to the detection component 104. A plurality of positron annihilation events occur in an actual detection region of the detection member, and two gamma photons with opposite flight directions are generated after positron annihilation. The detection component 104 captures the gamma photons to obtain photon information and transmits the photon information to the coincidence processing component 102. The coincidence processing unit 102 outputs coincidence data corresponding to the target response line according to the photon information transmitted by the detection unit 104. The coincidence processing component 102 can be, but is not limited to, various personal computers, notebook computers, smart phones, and tablet computers.
In one embodiment, as shown in fig. 2, a method for outputting coincidence data is provided, and the method is applied to the coincidence processing component in fig. 1, for example, and includes the following steps:
step 201, determining a plurality of coincidence events and first response lines corresponding to the coincidence events according to photon information captured by the detection component.
One positron annihilates to generate a photon pair, and two photons in the photon pair are respectively captured by two detectors in the detection component, and a straight line of the photon flight between the two detectors is a response Line (LOR). Such as B1, B2, B3, B4 in fig. 3a and 3B.
The detection component transmits the captured photon information to the coincidence processing component, and then the coincidence processing component obtains events of a plurality of positron annihilation photon pairs according to the transmitted photon information, wherein each event of photon pair generation corresponds to a response line. Then, the coincidence processing component judges whether the events generating photon pairs are coincidence events, and if the events generating photon pairs are determined to be coincidence events, the response line corresponding to the coincidence events is determined to be a first response line.
For example, the coincidence processing means obtains events A1 and A2 … … An of a plurality of positron annihilation-generated photon pairs, and response lines corresponding to the events are B1 and B2 … … Bn, respectively. If the event A1 is determined to be a coincidence event, a response line B1 corresponding to the event A1 is determined to be a first response line. If it is determined that the event A2 is not a coincidence event, the response line B2 corresponding to the event A2 is not the first response line. Similarly, a plurality of first lines of response may be determined.
Step 202, a region of interest selected by a user is acquired, and a plurality of second response lines passing through the region of interest are selected from a plurality of first response lines.
In practical application, the user focuses more on the image corresponding to the region of interest, so that the user selects the region of interest from the actual detection region of the detector, and after the coincidence processing component acquires the region of interest selected by the user, the first response line passing through the region of interest is screened out and used as the second response line.
As shown in fig. 3a and 3B, the hatched portion corresponds to the region of interest, and the first response line B1 passes through the region of interest, the first response line B1 is screened as the second response line. The first response line B3 does not pass through the region of interest, and the first response line B3 is not screened as the second response line. Similarly, a second line of response may be screened from the plurality of first lines of response.
It will be appreciated that, depending on whether the response line passes through the region of interest, a portion of the response lines that do not pass through the region of interest may be removed, so as to subsequently remove redundant data corresponding to the response lines.
At step 203, a target response line having a photon pair generation position within the region of interest is selected from the plurality of second response lines.
The coincidence processing component determines photon pair generation positions corresponding to each second response line; and judging whether the photon pair generating position is positioned in the region of interest, and screening the corresponding second response line as a target response line if the photon pair generating position is positioned in the region of interest.
For example, if the photon pair generating position C1 corresponding to the second response line B1 is located in the region of interest, the second response line B1 is screened as the target response line. And if the photon pair generation position C4 corresponding to the second response line B4 is not in the region of interest, the second response line B4 is not screened as a target response line. Similarly, a target line of response may be screened from the plurality of second lines of response.
It can be appreciated that, according to whether the photon pair generating position is located in the region of interest, the response lines are further screened, and a part of response lines of which the photon pair generating position is not located in the region of interest can be removed, so that redundant data corresponding to the response lines can be removed later.
And 204, outputting the coincidence data corresponding to the target response line.
The target response line is a response line passing through the region of interest, and the photon pair generation position is in the region of interest; the non-target lines other than the target line may be lines that do not pass through the region of interest, or may be lines that pass through the region of interest but the photon pair generation locations are not within the region of interest.
After the target response line is determined, the coincidence processing component outputs coincidence data corresponding to the target response line, but does not output coincidence data corresponding to the non-target response line, so that the finally output coincidence data are related to the region of interest, and redundant data are less.
In the method for outputting coincidence data, a plurality of coincidence events and first response lines corresponding to the coincidence events are determined according to photon information captured by a detection component; acquiring an interested region selected by a user, and screening a plurality of second response lines penetrating through the interested region from a plurality of first response lines; screening out target response lines with photon pairs in the interested region from the second response lines; and outputting the coincidence data corresponding to the target response line. According to the embodiment of the disclosure, the first response line corresponding to the coincidence event is screened twice according to the region of interest, redundant data irrelevant to the region of interest is removed, and because the redundant data is reduced, the image reconstruction time can be shortened, the data storage pressure is reduced, and therefore the disk space tension is avoided.
In one embodiment, as shown in fig. 4, the detecting unit includes a plurality of detectors, and each two detectors form a detector pair; the coincidence processing component includes a plurality of sub-coincidence processing components, each of which is coupled to a detector pair. As shown in fig. 5, the step of determining a plurality of coincidence events and a first response line corresponding to each coincidence event according to photon information captured by the detecting component may include:
step 301, for each sub-coincidence processing component, determining a time-of-flight difference for a photon pair from photon information captured by the corresponding detector pair.
Each detector pair includes a first detector and a second detector; the positron annihilates to produce two photons, one of which is captured by a first detector and the other of which is captured by a second detector. The first detector and the second detector then transmit the captured photon information to the sub-coincidence processing component to which the detector pair corresponds.
The sub-coincidence processing component determines a first flight time and a second flight time according to photon information captured by the first detector and the second detector respectively; and calculating the absolute value of the difference value between the first flight time and the second flight time to obtain the flight time difference of the photon pair.
Wherein the first time of flight is the time from generation of one photon to capture by the first detector and the second time of flight is the time from generation of another photon to capture by the second detector. For example, the first time of flight is Ta and the second time of flight is Tb, then the time of flight difference for the photon pair is Δt= |ta-tb|.
Step 302, determining whether the event generating the photon pair is a coincidence event according to the flight time difference of the photon pair and the preset window width.
After the photon coincidence processing component obtains the flight time difference of the photon pair, judging whether the flight time difference of the photon pair is smaller than a preset window width; if the time-of-flight difference is less than the preset window width, determining the event generating the photon pair as a coincidence event.
For example, the predetermined window width is [ x1, x2], and if x1 < [ delta ] T < x2, then the event that produces the photon pair is determined to be a coincidence event. Wherein x1 may be 0, x2 may be ≡, and the preset window width is not limited in the embodiment of the present disclosure.
If it is determined that the event generating the photon pair is a coincidence event, a first line of response is determined according to the position of the detector pair corresponding to the coincidence event, step 303.
If it is determined that the event generating the photon pair is a coincidence event, then a pair of detectors detecting the photon pair may be determined, and a first line of response may be obtained by connecting the two detectors of the pair.
In the step of determining a plurality of coincidence events and first response lines corresponding to the coincidence events according to the photon information captured by the detection component, for each sub-coincidence processing component, determining a flight time difference of a photon pair according to the photon information captured by the corresponding detector pair; determining whether an event generating the photon pair is a coincidence event according to the flight time difference of the photon pair and a preset window width; if the event generating the photon pair is determined to be a coincidence event, a first response line is determined according to the position of the detector pair corresponding to the coincidence event. According to the embodiment of the disclosure, the coincidence processing component determines the coincidence event and the first response line corresponding to the coincidence event, and provides a basis for subsequent output of coincidence data.
In one embodiment, as shown in fig. 6, the step of acquiring the region of interest selected by the user and screening a plurality of second response lines passing through the region of interest from the plurality of first response lines may include:
step 401, a region setting interface is displayed.
Wherein, the display area corresponding to the actual detection area of the detection component is arranged in the area setting interface.
The conforming processing component can present the zone setting interface in a variety of ways, one of which can be that the conforming processing component includes a display component that presents the zone setting interface. Another way may be to control the display assembly to display the area setup interface in accordance with the processing assembly being coupled to the display assembly. The embodiments of the present disclosure are not limited in this regard.
And displaying the display areas corresponding to the detection parts and the actual detection areas of the detection parts in the area setting interface. The actual detection areas are different according to the different structures of the detection components, and the display areas corresponding to the actual detection areas are also different. As shown in fig. 3a, the plurality of detectors are annularly arranged to form a detection component, the internal area of the ring is an actual detection area, and the display area corresponding to the actual detection area displayed in the area setting interface is the internal area of the ring. As shown in fig. 3b, the plurality of detectors are sequentially arranged in the vertical direction to form detector UNITs UNIT0 and UNIT1 and … … UNIT7, and then sequentially arranged in the horizontal direction to form the detector UNIT, the area covered by the detectors is an actual detection area, and the display area corresponding to the actual detection area shown in the area setting interface is the detector coverage area.
Step 402, receiving a user selected region based on a region setting interface.
The user selection area is located in the display area.
After the display area is displayed in the area setting interface, the user can conduct drawing operation in the display area, and the processing component is matched with the user selection area determined according to the drawing operation. Such as the shaded portions in fig. 3a and 3 b.
The drawing operation may include a mouse drawing operation, a touch drawing operation, and the like. The embodiments of the present disclosure are not limited in this regard.
And step 403, mapping the user selected area according to a pre-established mapping relation to obtain the region of interest.
Wherein the region of interest is located within an actual detection region of the detection component; the mapping relation is used for representing the position corresponding relation between the display area and the actual detection area.
The coincidence processing component obtains the position coordinates of each point in the user selection area, maps each point in the user selection area into the actual detection area according to the mapping relation, and determines the interested area according to the position coordinates of each point after mapping.
For example, the coincidence processing part obtains the position coordinate of the point 1 in the user selection area as P1, and performs mapping processing on the P1 according to the mapping relation to obtain a position coordinate P1'; and obtaining the position coordinate of the point 2 in the user selected area as P2, and carrying out mapping processing on the P2 according to the mapping relation to obtain a position coordinate P2'. Similarly, position coordinates P1', P2', … … are obtained, from which the region of interest is determined.
If at least one point on the first line of response is located within the region of interest, the first line of response is determined to be a second line of response, step 404.
After determining the first response lines and the interested areas corresponding to the coincidence events, the coincidence processing component judges whether the points on the first response lines are positioned in the interested areas. If at least one point of the first line of response is located within the region of interest, it is indicated that the first line of response passes through the region of interest, and therefore the first line of response is determined to be the second line of response. If none of the points on the first line of response are within the region of interest, it is indicated that the first line of response does not traverse the region of interest, and therefore the first line of response is not determined to be the second line of response.
In the step of acquiring the region of interest selected by the user and screening out a plurality of second response lines penetrating through the region of interest from the plurality of first response lines, an area setting interface is displayed; receiving a user selected region based on a region setting interface; mapping the user selected region according to a pre-established mapping relation to obtain a region of interest; if at least one point on the first response line is located within the region of interest, the first response line is determined to be the second response line. According to the embodiment of the disclosure, the coincidence processing component acquires the region of interest and performs preliminary screening on the first response line according to the region of interest, so that redundant data corresponding to the first response line which does not pass through the region of interest can be removed, the image reconstruction time is shortened, and the data storage pressure is reduced.
In one embodiment, as shown in fig. 7, the step of screening the plurality of second response lines to generate the target response line with the position within the region of interest may include:
step 501, determining photon pair generation positions corresponding to each second response line.
The coincidence processing component may determine the photon pair generation location based on a time of flight of the photon pair corresponding to the second line of response. The determining process may include: determining the distance between two detectors corresponding to the second response lines, the first flight time and the second flight time according to the second response lines; and calculating the photon pair generation position corresponding to the second response line according to the distance between the two detectors, the first flight time and the second flight time.
For example, the distance between the two detectors corresponding to the second response line is L, the first flight time is Ta, the second flight time is Tb, the distance between the photon pair generating position and the first detector is la=l×ta/(ta+tb), and the photon pair generating position can be determined according to the distances L and la; alternatively, the distance between the photon pair generating position and the second detector is calculated to be lb=l×tb/(ta+tb), and the photon pair generating position is determined according to the distances L and lb.
Step 502, if the photon pair generation position corresponding to the second response line is located in the region of interest, determining the second response line as the target response line.
After determining the photon pair generating positions corresponding to the second response lines, judging whether the photon pair generating positions are in the interested area or not. If the photon pair production location is within the region of interest, a corresponding second line of response is determined to be the target line of response. If the photon pair production location is not within the region of interest, the corresponding second line of response is not determined to be the target line of response.
In the step of selecting the target response line with the photon pair generation position located in the region of interest from the plurality of second response lines, the coincidence processing component determines the photon pair generation position corresponding to each second response line, and if the photon pair generation position corresponding to the second response line is located in the region of interest, the second response line is determined as the target response line. According to the embodiment of the disclosure, the coincidence processing component further screens the response line to obtain the target response line according to whether the photon pair generating position is in the region of interest, so that redundant data corresponding to the response line of which the photon pair generating position is not in the region of interest is removed, the image reconstruction time can be shortened, and the data storage pressure can be reduced.
In one embodiment, as shown in fig. 8, the step of outputting the coincidence data corresponding to the target response line may include:
and 601, screening target sub-coincidence processing components from a plurality of sub-coincidence processing components according to the target response line.
Each sub-coincidence processing member is coupled to a detector pair, each detector pair corresponding to a line of response, i.e., each sub-coincidence processing member corresponds to a line of response. And after the target response line is screened out from the plurality of response lines, the target sub-coincidence processing component is screened out from the plurality of sub-coincidence processing components according to the corresponding relation between the sub-coincidence processing component and the response line.
In step 602, the control target sub-coincidence processing part outputs coincidence data.
And after the target sub-coincidence processing component is screened out, controlling the target sub-coincidence processing component to output coincidence data. Because the target response line is strongly correlated with the region of interest, the output coincidence data is also strongly correlated with the region of interest, and an image corresponding to the region of interest can still be obtained by performing image reconstruction according to the output coincidence data.
The process of outputting the coincidence data by the control sub-coincidence processing part may include: the target subcompartment processing unit receives the enable signal and outputs coincidence data.
In the step of outputting the coincidence data corresponding to the target response line, the target sub-coincidence processing component is screened out from the plurality of sub-coincidence processing components according to the target response line; the control target sub-coincidence processing section outputs coincidence data. According to the embodiment of the disclosure, the output coincidence data are strongly related to the region of interest, and redundant data weakly related to the region of interest are removed, so that the image reconstruction time can be shortened, and the data storage pressure can be reduced.
It should be understood that, although the steps in the flowcharts of fig. 2 to 8 are sequentially shown as indicated by arrows, these steps are not necessarily sequentially performed in the order indicated by the arrows. The steps are not strictly limited to the order of execution unless explicitly recited herein, and the steps may be executed in other orders. Moreover, at least a portion of the steps of fig. 2-8 may include steps or stages that are not necessarily performed at the same time, but may be performed at different times, nor does the order in which the steps or stages are performed necessarily occur sequentially, but may be performed alternately or alternately with other steps or at least a portion of the steps or stages in other steps.
In one embodiment, as shown in fig. 9, there is provided an output device conforming to data, including:
an event determining module 701, configured to determine a plurality of coincidence events and a first response line corresponding to each coincidence event according to photon information captured by the detecting component;
a first screening module 702, configured to obtain a region of interest selected by a user, and screen a plurality of second response lines passing through the region of interest from a plurality of first response lines;
a second screening module 703, configured to screen the target response lines with photon pairs generated in the region of interest from the plurality of second response lines;
and the data output module 704 is configured to output the coincidence data corresponding to the target response line.
In one embodiment, the first screening module 702 is specifically configured to display an area setting interface; the display area corresponding to the actual detection area of the detection component is arranged in the area setting interface; receiving a user selected region based on a region setting interface; the user selection area is located within the display area.
In one embodiment, the first filtering module 702 is specifically configured to perform mapping processing on a user selected area according to a pre-established mapping relationship to obtain a region of interest; the region of interest is located within an actual detection region of the detection component; if at least one point on the first response line is located within the region of interest, the first response line is determined to be the second response line.
In one embodiment, the detecting component comprises a plurality of detectors, and each two detectors form a detector pair; the coincidence processing component comprises a plurality of sub-coincidence processing components, and each sub-coincidence processing component is connected with one detector pair; the event determination module 701 includes:
the time difference determining submodule is used for determining the flight time difference of the photon pairs according to the photon information captured by the corresponding detector pairs aiming at each sub coincidence processing component;
the event determination submodule is used for determining whether an event generating the photon pair is a coincidence event according to the flight time difference of the photon pair and a preset window width;
and the response line determination submodule is used for determining a first response line according to the position of the detector pair corresponding to the coincidence event if the event generating the photon pair is determined to be the coincidence event.
In one embodiment, the detector pair includes a first detector and a second detector, and the time difference determining submodule is specifically configured to determine a first time of flight and a second time of flight according to photon information captured by the first detector and the second detector, respectively; wherein the first time of flight is the time from generation of one photon to capture by the first detector and the second time of flight is the time from generation of another photon to capture by the second detector; and calculating the absolute value of the difference value between the first flight time and the second flight time to obtain the flight time difference of the photon pair.
In one embodiment, the event determination submodule is specifically configured to determine whether a time difference of flight of the photon pair is smaller than a preset window width; if the time-of-flight difference is less than the preset window width, determining the event generating the photon pair as a coincidence event.
In one embodiment, the second screening module 703 includes:
the position determining submodule is used for determining photon pair generation positions corresponding to the second response lines;
and the screening sub-module is used for determining the second response line as a target response line if the photon pair generation position corresponding to the second response line is positioned in the region of interest.
In one embodiment, the location determining submodule is specifically configured to determine, for each second response line, a distance between two detectors corresponding to the second response line, a first flight time, and a second flight time; and calculating the photon pair generation position corresponding to the second response line according to the distance between the two detectors, the first flight time and the second flight time.
In one embodiment, the data output module 704 is specifically configured to screen the target sub-coincidence processing component from the plurality of sub-coincidence processing components according to the target response line; the control target sub-coincidence processing section outputs coincidence data.
For specific limitation of the output device according to the data, reference may be made to the limitation of the output method according to the data hereinabove, and the description thereof will not be repeated here. The above-described respective modules in the data-compliant output device may be implemented in whole or in part by software, hardware, or a combination thereof. The above modules may be embedded in hardware or may be independent of a processor in the computer device, or may be stored in software in a memory in the computer device, so that the processor may call and execute operations corresponding to the above modules.
In one embodiment, a computer device is provided, which may be a terminal, and an internal structure diagram thereof may be as shown in fig. 10. The computer device includes a processor, a memory, a communication interface, a display screen, and an input device connected by a system bus. Wherein the processor of the computer device is configured to provide computing and control capabilities. The memory of the computer device includes a non-volatile storage medium and an internal memory. The non-volatile storage medium stores an operating system and a computer program. The internal memory provides an environment for the operation of the operating system and computer programs in the non-volatile storage media. The communication interface of the computer device is used for carrying out wired or wireless communication with an external terminal, and the wireless mode can be realized through WIFI, an operator network, NFC (near field communication) or other technologies. The computer program is executed by a processor to implement a method of outputting conforming data. The display screen of the computer equipment can be a liquid crystal display screen or an electronic ink display screen, and the input device of the computer equipment can be a touch layer covered on the display screen, can also be keys, a track ball or a touch pad arranged on the shell of the computer equipment, and can also be an external keyboard, a touch pad or a mouse and the like.
It will be appreciated by those skilled in the art that the structure shown in fig. 10 is merely a block diagram of some of the structures associated with the present application and is not limiting of the computer device to which the present application may be applied, and that a particular computer device may include more or fewer components than shown, or may combine certain components, or have a different arrangement of components.
In one embodiment, a computer device is provided comprising a memory and a processor, the memory having stored therein a computer program, the processor when executing the computer program performing the steps of:
determining a plurality of coincidence events and first response lines corresponding to the coincidence events according to photon information captured by the detection component;
acquiring an interested region selected by a user, and screening a plurality of second response lines penetrating through the interested region from a plurality of first response lines;
screening out target response lines with photon pairs in the interested region from the second response lines;
and outputting the coincidence data corresponding to the target response line.
In one embodiment, the processor when executing the computer program further performs the steps of:
setting an interface in the display area; the display area corresponding to the actual detection area of the detection component is arranged in the area setting interface;
Receiving a user selected region based on a region setting interface; the user selection area is located within the display area.
In one embodiment, the processor when executing the computer program further performs the steps of:
mapping the user selected region according to a pre-established mapping relation to obtain a region of interest; the region of interest is located within an actual detection region of the detection component;
if at least one point on the first response line is located within the region of interest, the first response line is determined to be the second response line.
In one embodiment, the detection component comprises a plurality of detectors, each two detectors forming a detector pair; the coincidence processing component comprises a plurality of sub-coincidence processing components, and each sub-coincidence processing component is connected with one detector pair; the processor when executing the computer program also implements the steps of:
determining the flight time difference of the photon pair according to the photon information captured by the corresponding detector pair for each sub coincidence processing component;
determining whether an event generating the photon pair is a coincidence event according to the flight time difference of the photon pair and a preset window width;
if the event generating the photon pair is determined to be a coincidence event, a first response line is determined according to the position of the detector pair corresponding to the coincidence event.
In one embodiment, the detector pair comprises a first detector and a second detector, the processor when executing the computer program further implementing the steps of:
determining a first flight time and a second flight time according to photon information captured by the first detector and the second detector respectively; wherein the first time of flight is the time from generation of one photon to capture by the first detector and the second time of flight is the time from generation of another photon to capture by the second detector;
and calculating the absolute value of the difference value between the first flight time and the second flight time to obtain the flight time difference of the photon pair.
In one embodiment, the processor when executing the computer program further performs the steps of:
judging whether the flight time difference of the photon pair is smaller than a preset window width or not;
if the time-of-flight difference is less than the preset window width, determining the event generating the photon pair as a coincidence event.
In one embodiment, the processor when executing the computer program further performs the steps of:
determining photon pair generation positions corresponding to the second response lines;
and if the photon pair generation position corresponding to the second response line is positioned in the region of interest, determining the second response line as a target response line.
In one embodiment, the processor when executing the computer program further performs the steps of:
determining the distance between two detectors corresponding to the second response lines, the first flight time and the second flight time according to the second response lines;
and calculating the photon pair generation position corresponding to the second response line according to the distance between the two detectors, the first flight time and the second flight time.
In one embodiment, the processor when executing the computer program further performs the steps of:
screening target sub-coincidence processing components from the plurality of sub-coincidence processing components according to the target response line;
the control target sub-coincidence processing section outputs coincidence data.
In one embodiment, a computer readable storage medium is provided having a computer program stored thereon, which when executed by a processor, performs the steps of:
determining a plurality of coincidence events and first response lines corresponding to the coincidence events according to photon information captured by the detection component;
acquiring an interested region selected by a user, and screening a plurality of second response lines penetrating through the interested region from a plurality of first response lines;
screening out target response lines with photon pairs in the interested region from the second response lines;
And outputting the coincidence data corresponding to the target response line.
In one embodiment, the computer program when executed by the processor further performs the steps of:
setting an interface in the display area; the display area corresponding to the actual detection area of the detection component is arranged in the area setting interface;
receiving a user selected region based on a region setting interface; the user selection area is located within the display area.
In one embodiment, the computer program when executed by the processor further performs the steps of:
mapping the user selected region according to a pre-established mapping relation to obtain a region of interest; the region of interest is located within an actual detection region of the detection component;
if at least one point on the first response line is located within the region of interest, the first response line is determined to be the second response line.
In one embodiment, the detection component comprises a plurality of detectors, each two detectors forming a detector pair; the coincidence processing component comprises a plurality of sub-coincidence processing components, and each sub-coincidence processing component is connected with one detector pair; the computer program when executed by the processor also performs the steps of:
determining the flight time difference of the photon pair according to the photon information captured by the corresponding detector pair for each sub coincidence processing component;
Determining whether an event generating the photon pair is a coincidence event according to the flight time difference of the photon pair and a preset window width;
if the event generating the photon pair is determined to be a coincidence event, a first response line is determined according to the position of the detector pair corresponding to the coincidence event.
In one embodiment, the detector pair comprises a first detector and a second detector, the computer program when executed by the processor further implementing the steps of:
determining a first flight time and a second flight time according to photon information captured by the first detector and the second detector respectively; wherein the first time of flight is the time from generation of one photon to capture by the first detector and the second time of flight is the time from generation of another photon to capture by the second detector;
and calculating the absolute value of the difference value between the first flight time and the second flight time to obtain the flight time difference of the photon pair.
In one embodiment, the computer program when executed by the processor further performs the steps of:
judging whether the flight time difference of the photon pair is smaller than a preset window width or not;
if the time-of-flight difference is less than the preset window width, determining the event generating the photon pair as a coincidence event.
In one embodiment, the computer program when executed by the processor further performs the steps of:
Determining photon pair generation positions corresponding to the second response lines;
and if the photon pair generation position corresponding to the second response line is positioned in the region of interest, determining the second response line as a target response line.
In one embodiment, the computer program when executed by the processor further performs the steps of:
determining the distance between two detectors corresponding to the second response lines, the first flight time and the second flight time according to the second response lines;
and calculating the photon pair generation position corresponding to the second response line according to the distance between the two detectors, the first flight time and the second flight time.
In one embodiment, the computer program when executed by the processor further performs the steps of:
screening target sub-coincidence processing components from the plurality of sub-coincidence processing components according to the target response line;
the control target sub-coincidence processing section outputs coincidence data.
Those skilled in the art will appreciate that implementing all or part of the above described methods may be accomplished by way of a computer program stored on a non-transitory computer readable storage medium, which when executed, may comprise the steps of the embodiments of the methods described above. Any reference to memory, storage, database, or other medium used in embodiments provided herein may include at least one of non-volatile and volatile memory. The nonvolatile Memory may include Read-Only Memory (ROM), magnetic tape, floppy disk, flash Memory, optical Memory, or the like. Volatile memory can include random access memory (Random Access Memory, RAM) or external cache memory. By way of illustration, and not limitation, RAM can be in the form of a variety of forms, such as static random access memory (Static Random Access Memory, SRAM) or dynamic random access memory (Dynamic Random Access Memory, DRAM), and the like.
The technical features of the above embodiments may be arbitrarily combined, and all possible combinations of the technical features in the above embodiments are not described for brevity of description, however, as long as there is no contradiction between the combinations of the technical features, they should be considered as the scope of the description.
The above examples merely represent a few embodiments of the present application, which are described in more detail and are not to be construed as limiting the scope of the invention. It should be noted that it would be apparent to those skilled in the art that various modifications and improvements could be made without departing from the spirit of the present application, which would be within the scope of the present application. Accordingly, the scope of protection of the present application is to be determined by the claims appended hereto.

Claims (10)

1. A method of outputting coincidence data, characterized by being applied to a coincidence processing member, the coincidence processing member being connected to a detection member, the method comprising:
determining a plurality of coincidence events and first response lines corresponding to the coincidence events according to photon information captured by the detection component;
acquiring a region of interest selected by a user, and screening a plurality of second response lines passing through the region of interest from a plurality of first response lines;
Screening photon pairs from a plurality of the second response lines to generate target response lines with positions in the region of interest;
outputting coincidence data corresponding to the target response line;
the screening of photon pairs from the plurality of second response lines to produce target response lines with locations within the region of interest comprises:
determining photon pair generation positions corresponding to the second response lines;
if the photon pair generation position corresponding to the second response line is located in the region of interest, determining the second response line as the target response line;
the determining the photon pair generation position corresponding to each second response line includes:
determining a distance between two detectors corresponding to the second response lines, a first flight time and a second flight time for each second response line;
and calculating photon pair generation positions corresponding to the second response line according to the distance between the two detectors, the first flight time and the second flight time.
2. The method of claim 1, wherein the acquiring the user-selected region of interest comprises:
setting an interface in the display area; the display area corresponding to the actual detection area of the detection component is arranged in the area setting interface;
Receiving a user selected area based on the area setting interface; the user selection area is located within the display area.
3. The method of claim 2, wherein the screening a plurality of second lines of response across the region of interest from the plurality of first lines of response comprises:
mapping the user selected area according to a pre-established mapping relation to obtain the region of interest; the region of interest is located within an actual detection region of the detection component;
and if at least one point on the first response line is positioned in the region of interest, determining the first response line as the second response line.
4. The method of claim 1, wherein the detection means comprises a plurality of detectors, each two of the detectors forming a detector pair; the coincidence processing component comprises a plurality of sub-coincidence processing components, each of which is connected with one of the detector pairs; the determining a plurality of coincidence events and a first response line corresponding to each coincidence event according to photon information captured by the detection component includes:
determining, for each of the sub-coincidence processing components, a time-of-flight difference for a photon pair based on photon information captured by the corresponding detector pair;
Determining whether an event generating the photon pair is the coincidence event according to the flight time difference of the photon pair and a preset window width;
and if the event generating the photon pair is determined to be a coincidence event, determining the first response line according to the position of the detector pair corresponding to the coincidence event.
5. The method of claim 4, wherein the detector pairs comprise a first detector and a second detector, and wherein determining the time-of-flight difference for a photon pair based on photon information captured by the corresponding detector pair comprises:
determining a first flight time and a second flight time according to photon information captured by the first detector and the second detector respectively; wherein the first time of flight is the time from generation of one photon to capture by the first detector and the second time of flight is the time from generation of another photon to capture by the second detector;
and calculating the absolute value of the difference value between the first flight time and the second flight time to obtain the flight time difference of the photon pair.
6. The method of claim 4, wherein said determining whether an event generating said photon pair is said coincidence event based on a time of flight difference and a preset window width of said photon pair comprises:
Judging whether the flight time difference of the photon pair is smaller than the preset window width or not;
and if the flight time difference is smaller than the preset window width, determining the event generating the photon pair as the coincidence event.
7. The method of any one of claims 1-6, wherein said calculating photon pair production locations for said second line of response from a distance between said two detectors, said first time of flight, and said second time of flight comprises;
calculating a photon pair generating position corresponding to the second response line according to the distance between the two detectors and the first flight time, the second flight time and the distance between the photon pair generating position and the first detector;
the photon pair producing location is determined from the distance between the two detectors and the distance between the photon pair producing location and the first detector.
8. An output device for coincidence data, characterized by being applied to a coincidence processing member, the coincidence processing member being connected to a detection member, the device comprising:
the event determining module is used for determining a plurality of coincidence events and first response lines corresponding to the coincidence events according to photon information captured by the detecting component;
The first screening module is used for acquiring a region of interest selected by a user and screening a second response line passing through the region of interest from a plurality of first response lines;
the second screening module is used for screening out photon pairs from a plurality of second response lines to generate target response lines with positions in the region of interest;
the data output module is used for outputting the coincidence data corresponding to the target response line;
wherein, the second screening module includes:
the position determining submodule is used for determining photon pair generation positions corresponding to the second response lines;
a screening sub-module, configured to determine the second response line as the target response line if a photon pair generation position corresponding to the second response line is located in the region of interest;
the position determining submodule is further used for determining the distance between two detectors corresponding to the second response lines, the first flight time and the second flight time for each second response line; and calculating photon pair generation positions corresponding to the second response line according to the distance between the two detectors, the first flight time and the second flight time.
9. A computer device comprising a memory and a processor, the memory storing a computer program, characterized in that the processor implements the steps of the method of any of claims 1 to 7 when the computer program is executed.
10. A computer readable storage medium, on which a computer program is stored, characterized in that the computer program, when being executed by a processor, implements the steps of the method of any of claims 1 to 7.
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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105354427A (en) * 2015-11-17 2016-02-24 沈阳东软医疗系统有限公司 Conformation screening method and device
CN110025329A (en) * 2019-04-24 2019-07-19 上海联影医疗科技有限公司 Coincidence counting string drawing generating method, device, computer equipment and storage medium
CN110432923A (en) * 2019-08-14 2019-11-12 上海联影医疗科技有限公司 Image rebuilding method, device, computer equipment and storage medium

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110378218A (en) * 2019-06-13 2019-10-25 大亚湾核电运营管理有限责任公司 A kind of image processing method, device and terminal device

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105354427A (en) * 2015-11-17 2016-02-24 沈阳东软医疗系统有限公司 Conformation screening method and device
CN110025329A (en) * 2019-04-24 2019-07-19 上海联影医疗科技有限公司 Coincidence counting string drawing generating method, device, computer equipment and storage medium
CN110432923A (en) * 2019-08-14 2019-11-12 上海联影医疗科技有限公司 Image rebuilding method, device, computer equipment and storage medium

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