CN110432923A - Image rebuilding method, device, computer equipment and storage medium - Google Patents
Image rebuilding method, device, computer equipment and storage medium Download PDFInfo
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- A61B6/52—Devices using data or image processing specially adapted for radiation diagnosis
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Abstract
This application involves a kind of image rebuilding method, device, computer equipment and storage mediums.The described method includes: the flight time based on each photon obtains the flight time difference for meeting photon；The flight time difference is sent to image reconstruction machine and carries out image reconstruction.Above-mentioned image rebuilding method, device, computer equipment and storage medium, the flight time difference for meeting photon is obtained by the flight time based on each photon, and the flight time difference is sent to the method that image reconstruction machine carries out image reconstruction, the calculating of flight time difference is first completed before transferring data to image reconstruction machine, then it only needs flight time difference being sent to image reconstruction machine, to effectively reduce data transfer bandwidth, it is time-consuming to shorten transmission, accelerates image reconstruction speed.
Description
Technical field
This application involves the field of medical instrument technology, more particularly to a kind of image rebuilding method, device, computer equipment
And storage medium.
Background technique
Positron emission computed tomography (Positron Emission Tomography, PET) is a kind of utilization
Inside to organism inject positron radioactivity isotope labelling compound, and measure in vitro they spatial distribution and when
Between characteristic three-dimensional imaging non-destructive testing technology, have the characteristics that high sensitivity, accuracy be good, accurate positioning.
The working principle of PET are as follows: by the radioisotope labeling for emitting positive electron to can participate in tissue blood flow or
On the compound of metabolic process, the radionuclide for indicating positively charged sub- compound is injected into subject's body, allows subject
PET imaging is carried out within the scope of the effective field of view of PET.During PET scan, the positive electron that active nucleus is launched is in vivo
Annihilation radiation (i.e. annihilation event) occurs in conjunction with the negative electron in tissue after mobile about 1mm, it is equal, square to generate two energy
To opposite γ photon.Since two γ photons distance in vivo is different, reach two detectors time also have it is certain poor
Not, if in defined time window (such as 0-15us), the probe system in line of response detects two and is mutually 180 degree
When the photon of (± 0.25 degree), constitutes one and meet event, processing equipment will record the data of response, and initial data passes through
Image Reconstruction Technology, image required for can get.
Traditional PET system meets processing unit after carrying out meeting judgement to γ photo-event, by what is screened
The flight time of two γ photons is co-energy, position etc. meets data information and is transferred to image reconstruction machine together, then image weight
It builds machine and calculates difference further according to two flight time, finally could be accurately positioned γ photon and fall into oblivion vanishing point, then progress image weight
It builds.But this method needs the flight time that two meet photon being all transferred to image reconstruction machine, to data transfer bandwidth
It is more demanding, and transmission takes a long time, and reduces image reconstruction speed.
Summary of the invention
Based on this, it is necessary in view of the above technical problems, provide a kind of image rebuilding method, device, computer equipment and
Storage medium.
A kind of image rebuilding method, which comprises
Flight time based on each photon obtains the flight time difference for meeting photon；
The flight time difference is sent to image reconstruction machine and carries out image reconstruction.
The flight time based on each photon obtains the flight time difference for meeting photon in one of the embodiments,
Include:
Based on the flight time of each photon, by field programmable gate array calculate described in meet the differential time of flight of photon
Value.
The flight time based on each photon obtains the flight time difference for meeting photon in one of the embodiments,
Further include:
Flight time based on detector signal and each photon carries out photon to meet judgement, filters out and meets photon；
The flight time difference for meeting photon is calculated based on the flight time for meeting photon.
The flight time based on each photon obtains the flight time difference for meeting photon in one of the embodiments,
Include:
Based on detector signal and the position encoded situation that meets for judging to meet photon, the situation that meets includes two symbols
Whether light combination is within the same clock cycle；
Based on the flight time and the flight time difference for meeting situation calculating and meeting photon for meeting photon.
It is described in one of the embodiments, that photon is met with situation calculating is met based on the flight time for meeting photon
Flight time difference includes:
When meeting photon within the same clock cycle for two, the flight time that two meet photon is subtracted each other to obtain institute
State the flight time difference for meeting photon.
It is described in one of the embodiments, that photon is met with situation calculating is met based on the flight time for meeting photon
Flight time difference further include:
When meeting photon not within the same clock cycle for two, difference based on the flight time for meeting photon and
The flight time difference for meeting photon is calculated in clock cycle.
The difference and clock cycle based on the flight time for meeting photon calculates in one of the embodiments,
Include: to the flight time difference for meeting photon
By the subtractive for the flight time that two meet photon go a clock cycle obtain it is described meet the flight of photon when
Between difference.
A kind of equipment for reconstructing image, described device include:
Module is obtained, the flight time difference for meeting photon is obtained for the flight time based on each photon；
Sending module carries out image reconstruction for the flight time difference to be sent to image reconstruction machine.
A kind of computer equipment, including memory and processor, the memory are stored with computer program, the processing
Device performs the steps of when executing the computer program
Flight time based on each photon obtains the flight time difference for meeting photon；
The flight time difference is sent to image reconstruction machine and carries out image reconstruction.
A kind of computer readable storage medium, is stored thereon with computer program, and the computer program is held by processor
It is performed the steps of when row
Flight time based on each photon obtains the flight time difference for meeting photon；
The flight time difference is sent to image reconstruction machine and carries out image reconstruction.
Above-mentioned image rebuilding method, device, computer equipment and storage medium are obtained by the flight time based on each photon
The flight time difference for meeting photon is taken, and the flight time difference is sent to the side that image reconstruction machine carries out image reconstruction
Method first completes the calculating of flight time difference before transferring data to image reconstruction machine, then only needs differential time of flight
Value is sent to image reconstruction machine, to effectively reduce data transfer bandwidth, shortens transmission time-consuming, accelerates image weight
Build speed.
Detailed description of the invention
Fig. 1 is the schematic diagram of image rebuilding method in one embodiment of the invention；
Fig. 2 is to meet the schematic diagram that photon meets situation in one embodiment of the invention；
Fig. 3 is the structural block diagram of equipment for reconstructing image in one embodiment of the invention；
Fig. 4 is the internal structure chart of computer equipment in one embodiment.
Specific embodiment
It is with reference to the accompanying drawings and embodiments, right in order to which the objects, technical solutions and advantages of the application are more clearly understood
The application is further elaborated.It should be appreciated that specific embodiment described herein is only used to explain the application, not
For limiting the application.
Referring to Fig. 1, Fig. 1 is the schematic diagram of the image rebuilding method of one embodiment of the invention.
In the present embodiment, described image method for reconstructing includes:
Step 100, the flight time based on each photon obtains the flight time difference for meeting photon.
Illustratively, the flight time based on each photon obtains the flight time difference for meeting photon including based on each
The flight time of photon, by field programmable gate array calculate described in meet the flight time difference of photon.It should be understood that
In other embodiments, the flight time difference of photon is met described in can calculating using other hardware chips.
FPGA (Field Programmable Gate Array) be on the basis of the programming devices such as PAL, GAL into
The product of one step development.It is that occur as one of the field specific integrated circuit (ASIC) semi-custom circuit, is both solved
It has determined the deficiency of custom circuit, and has overcome the limited disadvantage of original programming device gate circuit number.FPGA device belongs to dedicated
One of integrated circuit semi-custom circuit is programmable Logical Array, can be effectively solved original device gate circuit
The less problem of number.The basic structure of FPGA includes programmable input-output unit, configurable logic block, digital dock management mould
Block, embedded block RAM, interconnection resource embed dedicated stone, and bottom embeds functional unit.Since FPGA has interconnection resource rich
Richness, repeats programming and integrated level is high, invests lower feature, is widely used in Design of Digital Circuit field.
The design cycle of FPGA includes algorithm design, code emulation and design, trigger debugging, and designer and actual demand are established and calculated
Method framework establishes design scheme using EDA or HD writes design code, guarantees that design scheme meets by code emulation and is actually subjected to
It asks, finally carries out the debugging of plate grade, associated documents are downloaded in fpga chip using configuration circuit, verify actual motion effect.
Step 110, the flight time difference is sent to image reconstruction machine and carries out image reconstruction.
Illustratively, described image is rebuild machine and receives the flight time difference and positioned based on the flight time difference
γ photon falls into oblivion vanishing point, to carry out image reconstruction.
Above-mentioned image rebuilding method obtains the flight time difference for meeting photon by the flight time based on each photon,
And the flight time difference is sent to the method that image reconstruction machine carries out image reconstruction, transferring data to image reconstruction
The calculating that flight time difference is first completed before machine, then only needs flight time difference being sent to image reconstruction machine, from
And data transfer bandwidth is effectively reduced, transmission time-consuming is shortened, image reconstruction speed is accelerated.
The flight time based on each photon obtains the flight time difference for meeting photon in one of the embodiments,
Further include carrying out the flight time based on detector signal and each photon meeting judgement to photon, filters out and meet photon；It is based on
The flight time for meeting photon calculates the flight time difference for meeting photon.It should be understood that it is described meet photon and meet set
The γ photo-event of fixed condition can screen module and setting by meeting the position encoded and time-of-flight values feeding of photon
Window width value be compared screening and obtain.Specifically, the window width value can be practical according to system accuracy and clinical needs etc.
Situation is set, and at present the default windows width values of PET system are 4ns.
The flight time based on each photon calculates the flight time difference for meeting photon in one of the embodiments,
It further include based on detector signal and the position encoded situation that meets for judging to meet photon, the situation that meets meets including two
Whether photon is within the same clock cycle；Based on flight time for meeting photon and described meet situation calculating and meet photon
Flight time difference.Specifically, when meeting photon within the same clock cycle for two, when meeting the flight of photon for two
Between subtract each other to obtain the flight time difference for meeting photon；When meeting photon not within the same clock cycle for two, base
The flight time difference for meeting photon is calculated in the difference of the flight time for meeting photon and clock cycle.It can be with
Understand, when meeting photon not within the same clock cycle for two, the subtractive for the flight time that two meet photon is gone
The flight time difference for meeting photon can be obtained in one clock cycle.
Referring to Fig. 2, Fig. 2 is to meet the schematic diagram that photon meets situation in one embodiment of the invention.Specifically, with A and B
It represents a pair and meets γ photo-event, the time shaft that the time shaft of time1 represents γ photon A, time2 in Fig. 2 represents γ
Photon B, TDC_A and TDC_B respectively represent the flight time of γ photon A and γ photon B, and ta_tb indicates flying for two γ photons
Row time difference, Tclk represent a clock cycle, then when representing γ photon A and γ photon B in the same clock cycle, such as
Case1 and case2 in figure, ta_tb=TDC_A-TDC_B；When γ photon A is in the γ photon B previous clock cycle, as schemed
In case3, ta_tb=TDC_B-TDC_A-Tclk；When γ photon A is in γ photon B the latter clock cycle, in figure
Case4, ta_tb=TDC_B-TDC_A+Tclk.
It should be understood that although each step in the flow chart of Fig. 1 is successively shown according to the instruction of arrow, this
A little steps are not that the inevitable sequence according to arrow instruction successively executes.Unless expressly state otherwise herein, these steps
It executes there is no the limitation of stringent sequence, these steps can execute in other order.Moreover, at least part in Fig. 1
Step may include that perhaps these sub-steps of multiple stages or stage are executed in synchronization to multiple sub-steps
It completes, but can execute at different times, the execution sequence in these sub-steps or stage, which is also not necessarily, successively to be carried out,
But it can be executed in turn or alternately at least part of the sub-step or stage of other steps or other steps.
In one embodiment, as shown in figure 3, providing a kind of equipment for reconstructing image, comprising: obtain module 200 and hair
Send module 210, in which:
Module 200 is obtained, the flight time difference for meeting photon is obtained for the flight time based on each photon.
Module 200 is obtained, the flight time based on each photon is also used to, the symbol is calculated by field programmable gate array
The flight time difference of light combination.
Module 200 is obtained, is also used to:
Flight time based on detector signal and each photon carries out photon to meet judgement, filters out and meets photon；
The flight time difference for meeting photon is calculated based on the flight time for meeting photon.
Module 200 is obtained, is also used to:
Based on detector signal and the position encoded situation that meets for judging to meet photon, the situation that meets includes two symbols
Whether light combination is within the same clock cycle；
Based on the flight time and the flight time difference for meeting situation calculating and meeting photon for meeting photon.
Module 200 is obtained, is also used to meet photon for two when meeting photon within the same clock cycle for two
Flight time subtracts each other to obtain the flight time difference for meeting photon.
Module 200 is obtained, is also used to meet light based on described when meeting photon not within the same clock cycle for two
The flight time difference for meeting photon is calculated in the difference of the flight time of son and clock cycle.
Module 200 is obtained, is also used to go a clock cycle to obtain institute the subtractive for the flight time that two meet photon
State the flight time difference for meeting photon.
Sending module 210 carries out image reconstruction for the flight time difference to be sent to image reconstruction machine.
Specific about equipment for reconstructing image limits the restriction that may refer to above for image rebuilding method, herein not
It repeats again.Modules in above-mentioned equipment for reconstructing image can be realized fully or partially through software, hardware and combinations thereof.On
Stating each module can be embedded in the form of hardware or independently of in the processor in computer equipment, can also store in a software form
In memory in computer equipment, the corresponding operation of the above modules is executed in order to which processor calls.
In one embodiment, a kind of computer equipment is provided, which can be terminal, internal structure
Figure can be as shown in Figure 4.The computer equipment includes processor, the memory, network interface, display connected by system bus
Screen and input unit.Wherein, the processor of the computer equipment is for providing calculating and control ability.The computer equipment is deposited
Reservoir includes non-volatile memory medium, built-in storage.The non-volatile memory medium is stored with operating system and computer journey
Sequence.The built-in storage provides environment for the operation of operating system and computer program in non-volatile memory medium.The calculating
The network interface of machine equipment is used to communicate with external terminal by network connection.When the computer program is executed by processor with
Realize a kind of image rebuilding method.The display screen of the computer equipment can be liquid crystal display or electric ink display screen,
The input unit of the computer equipment can be the touch layer covered on display screen, be also possible to be arranged on computer equipment shell
Key, trace ball or Trackpad, can also be external keyboard, Trackpad or mouse etc..
It will be understood by those skilled in the art that structure shown in Fig. 4, only part relevant to application scheme is tied
The block diagram of structure does not constitute the restriction for the computer equipment being applied thereon to application scheme, specific computer equipment
It may include perhaps combining certain components or with different component layouts than more or fewer components as shown in the figure.
In one embodiment, a kind of computer equipment, including memory and processor are provided, is stored in memory
Computer program, the processor perform the steps of when executing computer program
Flight time based on each photon obtains the flight time difference for meeting photon；
The flight time difference is sent to image reconstruction machine and carries out image reconstruction.
In one embodiment, it is also performed the steps of when processor executes computer program
Based on the flight time of each photon, by field programmable gate array calculate described in meet the differential time of flight of photon
Value.
In one embodiment, it is also performed the steps of when processor executes computer program
Flight time based on detector signal and each photon carries out photon to meet judgement, filters out and meets photon；
The flight time difference for meeting photon is calculated based on the flight time for meeting photon.
In one embodiment, it is also performed the steps of when processor executes computer program
Based on detector signal and the position encoded situation that meets for judging to meet photon, the situation that meets includes two symbols
Whether light combination is within the same clock cycle；
Based on the flight time and the flight time difference for meeting situation calculating and meeting photon for meeting photon.
In one embodiment, it is also performed the steps of when processor executes computer program
When meeting photon within the same clock cycle for two, the flight time that two meet photon is subtracted each other to obtain institute
State the flight time difference for meeting photon.
In one embodiment, it is also performed the steps of when processor executes computer program
When meeting photon not within the same clock cycle for two, difference based on the flight time for meeting photon and
The flight time difference for meeting photon is calculated in clock cycle.
In one embodiment, it is also performed the steps of when processor executes computer program
By the subtractive for the flight time that two meet photon go a clock cycle obtain it is described meet the flight of photon when
Between difference.
In one embodiment, a kind of computer readable storage medium is provided, computer program is stored thereon with, is calculated
Machine program performs the steps of when being executed by processor
Flight time based on each photon obtains the flight time difference for meeting photon；
The flight time difference is sent to image reconstruction machine and carries out image reconstruction.
In one embodiment, it is also performed the steps of when computer program is executed by processor
Based on the flight time of each photon, by field programmable gate array calculate described in meet the differential time of flight of photon
Value.
In one embodiment, it is also performed the steps of when computer program is executed by processor
Flight time based on detector signal and each photon carries out photon to meet judgement, filters out and meets photon；
The flight time difference for meeting photon is calculated based on the flight time for meeting photon.
In one embodiment, it is also performed the steps of when computer program is executed by processor
Based on detector signal and the position encoded situation that meets for judging to meet photon, the situation that meets includes two symbols
Whether light combination is within the same clock cycle；
Based on the flight time and the flight time difference for meeting situation calculating and meeting photon for meeting photon.
In one embodiment, it is also performed the steps of when computer program is executed by processor
When meeting photon within the same clock cycle for two, the flight time that two meet photon is subtracted each other to obtain institute
State the flight time difference for meeting photon.
In one embodiment, it is also performed the steps of when computer program is executed by processor
When meeting photon not within the same clock cycle for two, difference based on the flight time for meeting photon and
The flight time difference for meeting photon is calculated in clock cycle.
In one embodiment, it is also performed the steps of when computer program is executed by processor
By the subtractive for the flight time that two meet photon go a clock cycle obtain it is described meet the flight of photon when
Between difference.
Above-mentioned image rebuilding method, device, computer equipment and storage medium are obtained by the flight time based on each photon
The flight time difference for meeting photon is taken, and the flight time difference is sent to the side that image reconstruction machine carries out image reconstruction
Method first completes the calculating of flight time difference before transferring data to image reconstruction machine, then only needs differential time of flight
Value is sent to image reconstruction machine, to effectively reduce data transfer bandwidth, shortens transmission time-consuming, accelerates image weight
Build speed.
Those of ordinary skill in the art will appreciate that realizing all or part of the process in above-described embodiment method, being can be with
Relevant hardware is instructed to complete by computer program, the computer program can be stored in a non-volatile computer
In read/write memory medium, the computer program is when being executed, it may include such as the process of the embodiment of above-mentioned each method.Wherein,
To any reference of memory, storage, database or other media used in each embodiment provided herein,
Including non-volatile and/or volatile memory.Nonvolatile memory may include read-only memory (ROM), programming ROM
(PROM), electrically programmable ROM (EPROM), electrically erasable ROM (EEPROM) or flash memory.Volatile memory may include
Random access memory (RAM) or external cache.By way of illustration and not limitation, RAM is available in many forms,
Such as static state RAM (SRAM), dynamic ram (DRAM), synchronous dram (SDRAM), double data rate sdram (DDRSDRAM), enhancing
Type SDRAM (ESDRAM), synchronization link (Synchlink) DRAM (SLDRAM), memory bus (Rambus) direct RAM
(RDRAM), direct memory bus dynamic ram (DRDRAM) and memory bus dynamic ram (RDRAM) etc..
Each technical characteristic of above embodiments can be combined arbitrarily, for simplicity of description, not to above-described embodiment
In each technical characteristic it is all possible combination be all described, as long as however, the combination of these technical characteristics be not present lance
Shield all should be considered as described in this specification.
The several embodiments of the application above described embodiment only expresses, the description thereof is more specific and detailed, but simultaneously
It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art
It says, without departing from the concept of this application, various modifications and improvements can be made, these belong to the protection of the application
Range.Therefore, the scope of protection shall be subject to the appended claims for the application patent.
Claims (10)
1. a kind of image rebuilding method, which is characterized in that the described method includes:
Flight time based on each photon obtains the flight time difference for meeting photon；
The flight time difference is sent to image reconstruction machine and carries out image reconstruction.
2. the method according to claim 1, wherein the flight time based on each photon obtains and meets photon
Flight time difference include:
Based on the flight time of each photon, by field programmable gate array calculate described in meet the flight time difference of photon.
3. method according to claim 1 or 2, which is characterized in that the flight time based on each photon, which obtains, to be met
The flight time difference of photon further include:
Flight time based on detector signal and each photon carries out photon to meet judgement, filters out and meets photon；
The flight time difference for meeting photon is calculated based on the flight time for meeting photon.
4. method according to claim 1 or 2, which is characterized in that the flight time based on each photon, which obtains, to be met
The flight time difference of photon includes:
Based on detector signal and it is position encoded judge to meet the situation that meets of photon, it is described meet situation and include two meet light
Whether son is within the same clock cycle；
Based on the flight time and the flight time difference for meeting situation calculating and meeting photon for meeting photon.
5. according to the method described in claim 4, it is characterized in that, it is described based on meet photon flight time and meet situation
It calculates and meets the flight time difference of photon and include:
When meeting photon within the same clock cycle for two, the flight time that two meet photon is subtracted each other to obtain the symbol
The flight time difference of light combination.
6. according to the method described in claim 4, it is characterized in that, it is described based on meet photon flight time and meet situation
Calculate the flight time difference for meeting photon further include:
When meeting photon not within the same clock cycle for two, difference and clock based on the flight time for meeting photon
The flight time difference for meeting photon is calculated in period.
7. according to the method described in claim 6, it is characterized in that, the difference based on the flight time for meeting photon and
The flight time difference for meeting photon is calculated in clock cycle
A clock cycle is gone to obtain the differential time of flight for meeting photon the subtractive for the flight time that two meet photon
Value.
8. a kind of equipment for reconstructing image, which is characterized in that described device includes:
Module is obtained, the flight time difference for meeting photon is obtained for the flight time based on each photon；
Sending module carries out image reconstruction for the flight time difference to be sent to image reconstruction machine.
9. a kind of computer equipment, including memory and processor, the memory are stored with computer program, feature exists
In the step of processor realizes any one of claims 1 to 7 the method when executing the computer program.
10. a kind of computer readable storage medium, is stored thereon with computer program, which is characterized in that the computer program
The step of method described in any one of claims 1 to 7 is realized when being executed by processor.
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| CN113538614A (en) * | 2021-06-25 | 2021-10-22 | 上海联影医疗科技股份有限公司 | Output method and device of coincidence data, computer equipment and storage medium |
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