CN113532944A - Biosynthetic thing sampling device - Google Patents
Biosynthetic thing sampling device Download PDFInfo
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- CN113532944A CN113532944A CN202110813667.3A CN202110813667A CN113532944A CN 113532944 A CN113532944 A CN 113532944A CN 202110813667 A CN202110813667 A CN 202110813667A CN 113532944 A CN113532944 A CN 113532944A
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- sampling
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- sample
- sampling device
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- 238000005070 sampling Methods 0.000 title claims abstract description 77
- 230000001851 biosynthetic effect Effects 0.000 title claims abstract description 10
- 230000007246 mechanism Effects 0.000 claims abstract description 66
- 230000001681 protective effect Effects 0.000 claims abstract description 29
- 238000001816 cooling Methods 0.000 claims abstract description 12
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 10
- 230000005540 biological transmission Effects 0.000 claims description 24
- 238000003466 welding Methods 0.000 claims description 8
- 230000005389 magnetism Effects 0.000 claims description 6
- 230000005611 electricity Effects 0.000 claims description 4
- 230000003028 elevating effect Effects 0.000 claims description 4
- 230000015572 biosynthetic process Effects 0.000 claims description 3
- 239000000853 adhesive Substances 0.000 claims description 2
- 230000001070 adhesive effect Effects 0.000 claims description 2
- 238000003786 synthesis reaction Methods 0.000 claims description 2
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 4
- 150000001875 compounds Chemical class 0.000 abstract description 3
- 230000007613 environmental effect Effects 0.000 abstract description 2
- 238000000034 method Methods 0.000 description 8
- 238000010586 diagram Methods 0.000 description 6
- 230000008569 process Effects 0.000 description 6
- 230000006872 improvement Effects 0.000 description 5
- 238000004378 air conditioning Methods 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 208000012260 Accidental injury Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229960000074 biopharmaceutical Drugs 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000007779 soft material Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
- G01N1/14—Suction devices, e.g. pumps; Ejector devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
- G01N2001/1062—Sampling under constant temperature, pressure, or the like
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- Life Sciences & Earth Sciences (AREA)
- Hydrology & Water Resources (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The invention discloses a biosynthetic compound sampling device, which structurally comprises a protective shell, a display screen, a switch, a sampling device, a power supply and an open switch, wherein an external computer transmits an electric signal to the sampling device through the power supply, when sampling is carried out, a worker places a placing frame with a reagent tube above a magnetic suction block above a base, a driving machine of a lifting device does work, the lifting device moves downwards in the stroke of a stroke rod to enable the sampling mechanism to sample in a sample mechanism, when the sampling mechanism samples, a cooling tube on the side surface of the placing frame is connected to deliver cold air to a sampling needle storage mechanism to enable the needle storage mechanism to be in a constant temperature state, the stability of biomolecules cannot be damaged due to the environmental temperature, when the needle mechanism needs to be cleaned, a protective sleeve is taken down, the needle mechanism is taken out, a needle at the front end of a needle tube is pulled down, and then the needle tube and the protective sleeve are sterilized, and after the disinfection operation is finished, replacing a new needle head, and then installing according to the steps.
Description
Technical Field
The invention relates to the technical field of biosynthesis, in particular to a biosynthesis sampling device.
Background
Half of the worldwide pharmaceuticals are biosynthesized, and particularly when the pharmaceuticals with complex molecular structures are synthesized, the method is simpler and more convenient than a chemical synthesis method and has higher economic benefit, and sampling detection is an indispensable process in the biopharmaceutical process;
sampling device that present laboratory used, basically all be single sampling device, but the daily needs of laboratory carry out the sample detection in a large number, the sample needle needs aseptic disinfection many times, the cleaning process is complicated, and easy accidental injury, sampling device is after the sample, can not detect immediately, the sample after the sample, because the sample storage is in sampling device, and in the transfer process, does not have controllable ambient temperature, can produce the qualitative change to the sample to influence the sample and detect the precision.
Disclosure of Invention
The technical scheme adopted by the invention for realizing the technical purpose is as follows: the utility model provides a biosynthetic thing sampling device, its structure includes protective housing, display screen, switch, sampling device, power, the protective housing openly with display screen bolted connection, the display screen is connected with the switch electricity, the protective housing is inside to be connected with sampling device bottom block, the switch is connected with the power electricity, sampling device comprises elevating gear, stroke pole, sampling mechanism, elevating gear left side and stroke pole bottom mechanical connection, stroke pole surface and sampling mechanism welded connection.
As a further improvement of the invention, the lifting device comprises a driving machine, a transmission shaft, a lifting sleeve and a sample mechanism, wherein the driving machine is in transmission connection with the transmission shaft, the transmission shaft is in threaded connection with the inner side of the lifting sleeve, the lifting sleeve is in welding connection with the sample mechanism, the driving machine is in transmission connection with the bottom end of the stroke rod, a gear of the driving machine is a bevel gear, and the bevel gear of the driving machine is intersected with the bevel gear at the bottom end of the transmission shaft at an angle of 90 degrees.
As a further improvement of the invention, the sample mechanism comprises a base, a magnetic suction block, a placing rack and a reagent tube, wherein the top end of the base is connected with the bottom end of the magnetic suction block in an adhesion manner, the top end of the magnetic suction block is in clearance fit with the placing rack, the placing rack is provided with a reagent tube storage hole, the base is arranged at the rear end of the driving machine, the magnetic suction block is circular, and the middle part of the magnetic suction block is provided with a convex block for clamping the placing rack.
As a further improvement of the invention, the sampling mechanism consists of a sampling needle storage mechanism, a linking frame and a cooling pipe, the sampling needle storage mechanism is connected with the right side of the linking frame in a welding manner, the cooling pipe is arranged on the left side surface of the linking frame, the linking frame is connected with the stroke rod in a welding manner, when the cooling pipe needs to operate, a pipe orifice at the lower end is connected with an external cooler, and the upper end is connected into the sampling needle storage mechanism.
As a further improvement of the invention, the sampling needle storage mechanism comprises a storage box, a cover plate, a rotating block and a needle mechanism, wherein the top end of the storage box is connected with the bottom end of the cover plate in a clamping manner, the top end of the rotating block is mechanically connected with the cover plate, the needle mechanism is arranged in the storage box, the bottom of the rotating block is connected with a connecting frame in a welding manner, the rotating block is a rotatable shaft block, the upper end of the rotating block and the cover plate are welded into a whole, and the cover plate can be rotated in the horizontal direction through the rotating block in the needle taking mechanism.
As a further improvement of the invention, the needle mechanism comprises a needle tube, a needle head and a protective sleeve, the bottom end of the needle tube is connected with the inner side of the needle head in a clamping manner, the bottom end of the needle head is connected with the protective sleeve in a clamping manner, the needle tube is in clearance fit with the storage box, and the protective sleeve is made of soft plastic materials and has good biocompatibility.
Advantageous effects
The invention relates to a biological compound sampling device, wherein a switch is turned on, an external computer transmits an electric signal to the sampling device in a protective shell through a power supply, a display screen can display the operation time, when sampling is carried out, a worker places a placing frame with a reagent tube on a magnetic suction block above a base, a driver of a lifting device does work, a bevel gear of the driver drives a bevel gear below a transmission shaft to rotate, the bevel gear of the driver is intersected with the bevel gear at the bottom end of the transmission shaft at an angle, so that transverse power is converted into vertical power, a thread above the transmission shaft and a thread of a lifting sleeve rotate, and the lifting device moves downwards in a stroke set by a stroke rod, so that the lower end of a sampling mechanism extends into a sample mechanism for sampling.
Compared with the prior art, the invention has the following beneficial effects:
when sampling mechanism takes a sample, the apron rotates through rotatory piece, make the storage box be the closed condition, link up the fixed cooling tube of frame side, can carry air conditioning to the storage box of sampling needle storage mechanism, make syringe needle mechanism be in the constant temperature state, and can not destroy biomolecule's stability because of ambient temperature, when needs wash syringe needle mechanism, take off the protective sheath, take out syringe needle mechanism, pull out the syringe needle of needle tubing front end, then kill the operation to needle tubing and protective sheath, change a new syringe needle after accomplishing the operation of killing, install according to the step again, can take a sample once more, make the sampling process can not receive the pollution.
Drawings
FIG. 1 is a schematic structural diagram of a biosynthetic product sampling apparatus according to the present invention.
Fig. 2 is a schematic structural diagram of a sampling device according to the present invention.
Fig. 3 is a schematic structural diagram of the lifting device of the present invention.
Fig. 4 is a schematic structural diagram of a sample mechanism according to the present invention.
Fig. 5 is a schematic structural diagram of the sampling mechanism of the present invention.
FIG. 6 is a schematic structural diagram of a sampling needle storage mechanism according to the present invention.
Fig. 7 is a schematic structural view of the needle mechanism of the present invention.
In the figure: the device comprises a protective shell-1, a display screen-2, a switch-3, a sampling device-4, a power supply-5, a lifting device-41, a travel rod-42, a sampling mechanism-43, a driving machine-41 a, a transmission shaft-41 b, a lifting sleeve-41 c, a sample mechanism-41 d, a base-d 1, a magnetic suction block-d 2, a placing rack-d 3, a reagent tube-d 4, a sampling needle storage mechanism-431, a connecting rack-432, a cooling tube-433, a storage box-1 a, a cover plate-1 b, a rotating block-1 c, a needle mechanism-b, a needle tube-b 1, a needle-b 2 and a protective sleeve-b 3.
Detailed Description
In order to make the technical means, the original characteristics, the achieved purposes and the effects of the invention easy to understand, the following description and the accompanying drawings further illustrate the preferred embodiments of the invention.
Example 1
As shown in figures 1 to 4:
the invention provides a biological compound sampling device which structurally comprises a protective shell 1, a display screen 2, a switch 3, a sampling device 4 and a power supply 5, wherein the front face of the protective shell 1 is connected with the display screen 2 through a bolt, the display screen 2 is electrically connected with the switch 3, the interior of the protective shell 1 is connected with the bottom end of the sampling device 4 in a clamping mode, the switch 3 is electrically connected with the power supply 5, the sampling device 4 consists of a lifting device 41, a stroke rod 42 and a sampling mechanism 43, the left side of the lifting device 41 is mechanically connected with the bottom of the stroke rod 42, and the outer surface of the stroke rod 42 is connected with the sampling mechanism 43 in a welding mode.
The lifting device 41 consists of a driving machine 41a, a transmission shaft 41b, a lifting sleeve 41c and a sample mechanism 41d, the driving machine 41a is in transmission connection with the transmission shaft 41b, the transmission shaft 41b is in threaded connection with the inner side of the lifting sleeve 41c, the lifting sleeve 41c is in welding connection with the sample mechanism 41d, the driving machine 41a is in transmission connection with the bottom end of the stroke rod 42, the gear of the driving machine 41a is a bevel gear, and the bevel gear of the driving machine 41a is intersected with the bevel gear at the bottom end of the transmission shaft 41b at an angle of 90 degrees, so that transverse power is converted into vertical power.
Wherein, sample mechanism 41d comprises base d1, magnetism piece d2, rack d3, reagent pipe d4, base d1 top and magnetism piece d2 bottom adhesive joint, magnetism piece d2 top and rack d3 clearance fit are inhaled, rack d3 is equipped with reagent pipe d4 and deposits the hole, driver 41a rear end is located to base d1, magnetism piece d2 is circular, and has a lug in the middle part for block rack d3 prevents rack d3 off tracking displacement.
The specific use mode and function of the embodiment are as follows:
in the invention, the switch 3 is turned on, an external computer transmits an electric signal to the sampling device 4 in the protective shell 1 through the power supply 5, the display screen 2 can display the operation time, when sampling is performed, a worker places the placing rack d3 containing the reagent tube d4 on the magnetic suction block d2 above the base d1, the driver 41a of the lifting device 41 does work, the bevel gear of the driver 41a drives the bevel gear below the transmission shaft 41b to rotate, the bevel gear of the driver 41a is intersected with the bevel gear at the bottom end of the transmission shaft 41b at an angle of 90 degrees, so that the transverse power is converted into the vertical power, the thread above the transmission shaft 41b and the thread of the lifting sleeve 41c rotate, the lifting device 41 moves downwards in the stroke set by the stroke rod 42, and the lower end of the sampling mechanism 43 extends into the sample mechanism 41d to perform sampling.
Example 2
As shown in fig. 5 to 7:
wherein, sampling mechanism 43 comprises sampling needle storage mechanism 431, linking frame 432, cooling tube 433, sampling needle storage mechanism 431 and linking frame 432 right side welded connection, linking frame 432 left side surface is equipped with cooling tube 433, linking frame 432 and stroke pole 42 welded connection, when cooling tube 433 needs to operate, meet lower extreme mouth of pipe and peripheral hardware cooler, inside the upper end inserts sampling needle storage mechanism 431, for sampling needle storage mechanism 431 real-time transport air conditioning.
The sampling needle storage mechanism 431 is composed of a storage box 1a, a cover plate 1b, a rotating block 1c and a needle mechanism b, the top end of the storage box 1a is connected with the bottom end of the cover plate 1b in a clamping mode, the top end of the rotating block 1c is mechanically connected with the cover plate 1b, the needle mechanism b is arranged inside the storage box 1a, the bottom of the rotating block 1c is connected with a linking frame 432 in a welding mode, the rotating block 1c is a rotatable shaft block, the upper end of the rotating block 1c is welded with the cover plate 1b into a whole, and the cover plate 1b is rotated in the horizontal direction through the rotating block 1c when the needle mechanism b is taken, so that the storage box 1a is in an open state.
Wherein, syringe needle mechanism b comprises needle tubing b1, syringe needle b2, protective sheath b3, needle tubing b1 bottom and the inboard block of syringe needle b2 are connected, syringe needle b2 bottom and protective sheath b3 block are connected, needle tubing b1 and storage box 1a clearance fit, protective sheath b3 is the soft material of moulding, has good biocompatibility, and protective sheath b3 meets with syringe needle b2, and the washing disinfection is convenient after the sample.
The specific use mode and function of the embodiment are as follows:
in the invention, when the sampling mechanism 43 performs sampling, the cover plate 1b rotates through the rotating block 1c to enable the storage box 1a to be in a closed state, the cooling pipe 433 fixed on the side surface of the connecting frame 432 can convey cold air to the storage box 1a of the sampling needle storage mechanism 431, so that the needle mechanism b is in a constant temperature state, the stability of biomolecules cannot be damaged due to the environmental temperature, when the needle mechanism b needs to be cleaned, the protective sleeve b3 is taken down, the needle mechanism b is taken out, the needle b2 at the front end of the needle tube b1 is pulled out, then the needle tube b1 and the protective sleeve b3 are sterilized, a new needle b2 is replaced after sterilization operation is completed, and installation is performed according to the steps, so that secondary sampling can be performed, and the sampling process cannot be polluted.
While there have been shown and described what are at present considered the fundamental principles of the invention, the essential features and advantages thereof, it will be understood by those skilled in the art that the present invention is not limited by the embodiments described above, which are merely illustrative of the principles of the invention, but rather, is capable of numerous changes and modifications in various forms without departing from the spirit or essential characteristics thereof, and it is intended that the invention be limited not by the foregoing descriptions, but rather by the appended claims and their equivalents.
Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.
Claims (6)
1. The utility model provides a biological synthesis thing sampling device, its structure includes protective housing (1), display screen (2), switch (3), sampling device (4), power (5), protective housing (1) openly with display screen (2) bolted connection, display screen (2) are connected with switch (3) electricity, protective housing (1) is inside to be connected with sampling device (4) bottom block, switch (3) are connected its characterized in that with power (5) electricity:
sampling device (4) comprise elevating gear (41), stroke pole (42), sampling mechanism (43), elevating gear (41) left side and stroke pole (42) bottom mechanical connection, stroke pole (42) surface and sampling mechanism (43) welded connection.
2. A biosynthetic product sampling apparatus according to claim 1, wherein: the lifting device (41) consists of a driving machine (41a), a transmission shaft (41b), a lifting sleeve (41c) and a sample mechanism (41d), wherein the driving machine (41a) is in transmission connection with the transmission shaft (41b), the transmission shaft (41b) is in threaded connection with the inner side of the lifting sleeve (41c), the lifting sleeve (41c) is in welding connection with the sample mechanism (41d), and the driving machine (41a) is in transmission connection with the bottom end of a stroke rod (42).
3. A biosynthetic product sampling apparatus according to claim 2, wherein: sample mechanism (41d) is inhaled piece (d2), rack (d3), reagent pipe (d4) by base (d1), magnetism and is constituteed, base (d1) top and magnetism inhale piece (d2) bottom adhesive connection, inhale piece (d2) top and rack (d3) clearance fit, rack (d3) is equipped with reagent pipe (d4) and deposits the hole, drive machine (41a) rear end is located in base (d 1).
4. A biosynthetic product sampling apparatus according to claim 1, wherein: sampling mechanism (43) are stored mechanism (431), are linked up frame (432), cooling tube (433) by the sampling needle and are constituteed, sampling needle storage mechanism (431) and link up frame (432) right side welded connection, link up frame (432) left side surface and be equipped with cooling tube (433), link up frame (432) and journey pole (42) welded connection.
5. A biosynthetic product sampling apparatus according to claim 4, wherein: sampling needle storage mechanism (431) comprises storage box (1a), apron (1b), rotatory piece (1c), syringe needle mechanism (b), storage box (1a) top is connected with apron (1b) bottom block, rotatory piece (1c) top and apron (1b) mechanical connection, inside storage box (1a) was located to syringe needle mechanism (b), rotatory piece (1c) bottom and linking frame (432) welded connection.
6. A biosynthetic product sampling apparatus according to claim 5, wherein: needle mechanism (b) comprises needle tubing (b1), syringe needle (b2), protective sheath (b3), needle tubing (b1) bottom and the inboard block of syringe needle (b2) are connected, syringe needle (b2) bottom and protective sheath (b3) block are connected, needle tubing (b1) and storage box (1a) clearance fit.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110813667.3A CN113532944A (en) | 2021-07-19 | 2021-07-19 | Biosynthetic thing sampling device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110813667.3A CN113532944A (en) | 2021-07-19 | 2021-07-19 | Biosynthetic thing sampling device |
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| Publication Number | Publication Date |
|---|---|
| CN113532944A true CN113532944A (en) | 2021-10-22 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110813667.3A Pending CN113532944A (en) | 2021-07-19 | 2021-07-19 | Biosynthetic thing sampling device |
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| CN (1) | CN113532944A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114252296A (en) * | 2021-12-21 | 2022-03-29 | 山东第一医科大学(山东省医学科学院) | A carry appearance equipment fast for pharmacy experiment |
-
2021
- 2021-07-19 CN CN202110813667.3A patent/CN113532944A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114252296A (en) * | 2021-12-21 | 2022-03-29 | 山东第一医科大学(山东省医学科学院) | A carry appearance equipment fast for pharmacy experiment |
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Application publication date: 20211022 |