CN113522214B

CN113522214B - Reaction device and method

Info

Publication number: CN113522214B
Application number: CN202110922796.6A
Authority: CN
Inventors: 邵鹏; 刘鹏; 王军; 张娜芹; 王伟; 段洪超
Original assignee: Xuanwu Hospital
Current assignee: Xuanwu Hospital
Priority date: 2021-08-11
Filing date: 2021-08-11
Publication date: 2023-01-17
Anticipated expiration: 2041-08-11
Also published as: CN113522214A

Abstract

The invention relates to a reaction device and a method. The reaction device at least comprises a reaction kettle. And the top of the reaction kettle is provided with an air guide pipe. The air duct is connected with the air pump. The reaction kettle is connected with the medicine bottle in an airtight way through a liquid guide pipe. The air pump is arranged in a mode that the air pressure in the reaction kettle can be changed, so that the medicament in the medicament bottle can enter and exit the reaction kettle based on the change of the air pressure. The invention provides a reaction device and a reaction method, which can enable a medicine bottle to contain a solvent before mixing and a mixed solution.

Description

Reaction device and method

Technical Field

The invention belongs to the field of medical instruments, and particularly relates to a reaction device and a reaction method.

Background

In some disease treatments, uniform mixing of the drugs is required to be completed before the drugs are taken, for example, in some respiratory disease treatments, a commonly used atomizer needs to be used for administration after uniform mixing of the drugs is completed before the drugs are taken; in addition, the existing medicines need to be prepared in situ before injection and transfusion, and the solid medicines are dissolved and then injected; in addition before the medicine goes on selling on the market, can test its property of a medicine, through placing the medicament in detecting the test tube, and then detect, can dilute the medicine before the detection achievement and mix into aqueous solution. Traditional medicine mixes is through medical staff manual operation, and medical staff often puts solid medicine into solvent medicine bottle and dissolves, through violent shake body, promotes the medicine and dissolves. Therefore, there is a need for a system or device that can automatically mix drugs and that can facilitate drug dissolution.

The patent with the publication number of CN212188772U provides a solid-liquid mixing device for medical pharmacy, and relates to the technical field of medical treatment. The solid-liquid mixing device for pharmacy in the medical field comprises a barrel, wherein a mixing mechanism is arranged in the barrel and extends out of the bottom of the barrel; mixing mechanism includes the motor, the motor is fixed to be located the barrel bottom, the motor passes through the first square pole of output shaft fixedly connected with, the barrel bottom is located and inside the barrel is extended into to first square pole. This solid-liquid mixing arrangement for medical field pharmacy through mixing mechanism's design, can make a plurality of first puddlers and a plurality of second puddlers can carry out the rebound of small range to can make the quick mixture of solid medicine and liquid medicine, avoid appearing the relative liquid medicine of solid medicine and be in the state of relative rest, be convenient for during the quick solution of solid medicine is to liquid medicine, improved the mixing efficiency of solid medicine and liquid medicine.

The Chinese patent with the publication number of CN112546362B discloses a medicine mixing device for an atomizer in the technical field of mixing devices, which comprises a placing frame, a medicine mixing cylinder, a sealing cover and a medicine dissolving cylinder, wherein the bottom of the sealing cover is provided with a threaded cylinder, a medicine feeding assembly, a driving assembly and a crushing plate are arranged in an inner cavity of the threaded cylinder, and the medicine mixing assembly is arranged on the medicine dissolving cylinder; dissolve the cartridge case and make the solid medicine after smashing be located the upper strata of liquid medicine to stir the liquid medicine through mixing the medicine subassembly, the liquid medicine that is stirred fully contacts with the solid medicine on upper strata, so that the medicine dissolves, after medicine dissolves, the volume reduces, can fall through dissolving the aperture on the cartridge case, and with the liquid medicine intensive mixing, avoid appearing traditional medicine device that mixes traditional medicine long-pending in the bottom of staying be not convenient for dissolve the problem of mixing.

Chinese patent publication No. CN213375999U discloses a medicine dissolving device for pharmaceutical analysis and detection, which comprises a housin, the top fixed mounting of casing has the feeder hopper, the dissolving tank has been seted up in the casing, fixed mounting has into the pencil in the casing, the feeder hopper with advance the inside intercommunication of pencil, advance pencil and the inside intercommunication of dissolving tank, fixed mounting has out the pencil in the dissolving tank, it has the water valve to go out the intraductal fixed mounting of pencil, one side fixed mounting of casing has the time-recorder, fixed mounting has the transparent plate in the casing, transparent plate and the inside intercommunication of dissolving tank. The utility model relates to a medicine dissolves technical field, utilizes different stirring direction to stir liquid, can make liquid medicine intensive mixing, has promoted the mixing efficiency between the multiple liquid medicine, avoids causing the influence to the result that pharmaceutical analysis detected.

Chinese patent publication No. CN110833646a discloses an atomizer for pediatric respiratory therapy, which relates to the technical field of medical instruments and comprises a box body, wherein a partition plate is arranged in the box body, the upper side surface and the lower side surface of the partition plate are respectively and fixedly connected with the upper side surface and the lower side surface of the inner wall of the box body, and a rotating device is clamped on the upper surface of the box body. This an atomizer for paediatrics respiratory tract treatment, through setting up the heating pipe, the heater strip, the puddler, temperature sensor and display, at first people add the liquid medicine to the box through the liquid medicine mouth, then make the heater strip work, the heater strip can produce heat at the during operation, and heat the liquid medicine through the heating pipe, later people rotate the handle, the handle is rotatory through the pivot puddler, not only can carry out intensive mixing with the liquid medicine, can also make the liquid medicine flow, accelerate the speed of the heating of liquid medicine, just can avoid the liquid medicine temperature to hang down amazing respiratory tract and make children appear uncomfortable condition excessively.

The Chinese invention with the publication number of CN108837736A discloses a mixing device for detecting a medicine mixed water solution, which comprises a fixing plate, wherein a supporting frame is welded on the outer wall of the top of the fixing plate, a motor is fixed on the inner wall of the top of the supporting frame through a bolt, a box body is welded on the outer wall of the top of the supporting frame, a round hole is formed in the outer wall of the bottom of the box body, a bearing is welded on the inner wall of the round hole, a transmission shaft is welded at the top end of an output shaft of the motor, the outer wall of one side of the transmission shaft is welded with the inner wall of the bearing, helical blades are welded on the outer wall of one side of the transmission shaft, which is close to the motor, stirring rods distributed equidistantly are welded on one end, which is far away from the motor, and a circular mounting hole is formed in the outer wall of the top of the box body. The device has a compact, practical and novel structure, can ensure that the mixed solution is stirred up and down and is fully mixed, provides a sample mixed solution with high accuracy, prevents the solution from being oxidized by air during mixing operation, sprays all-around in the box body, has more comprehensive cleaning operation, and is convenient for the use of the device next time.

In summary, the prior art has the following disadvantages:

1. whether the medicine is completely dissolved is judged according to the visual observation, and the accuracy is low;

2. only automatic mixing is realized, and the steps of adding and collecting medicines still need manual operation of medical staff;

3. the interference factors for solubility judgment by simply relying on optical detection are too many to be eliminated one by one.

In summary, in the prior art, a drug and a solvent are added into a reaction device through a feed port, and a mixed solution is collected through a discharge port after the drug and the solvent are mixed, which is very common. Because medical instruments have strict sanitary requirements, the medicine bottle containing the solvent becomes medical waste after the solvent is added into the reaction device from the feeding hole, and cannot be used for containing the mixed solution. In the prior art, under the condition that a mixed reaction device is used for mixing medicines, a solvent before mixing and a solution after mixing are contained in different medicine bottles. In the prior art, medical sanitation is guaranteed, but resource waste is generated, especially waste of medicine bottles. Traditional medicine mixes is with in the medicine direct addition solvent medicine bottle, then rocks through medical staff's hand and accomplishes the mixture of medicine and solvent, though this kind of mode can not waste the medicine bottle, has increased medical staff's intensity of labour, crowds the operating time who accounts for medical staff, also is a waste to medical resources. In view of the above problems, the present invention provides a reaction apparatus and method, which can enable a vial to contain both a pre-mixing solvent and a well-mixed solution.

Furthermore, on the one hand, due to the differences in understanding to the person skilled in the art; on the other hand, since the inventor has studied a lot of documents and patents when making the present invention, but the space is not limited to the details and contents listed in the above, however, the present invention is by no means free of the features of the prior art, but the present invention has been provided with all the features of the prior art, and the applicant reserves the right to increase the related prior art in the background.

Disclosure of Invention

Aiming at the defects of the prior art, the invention provides a reaction device. The reaction device at least comprises a reaction kettle. And the top of the reaction kettle is provided with an air guide pipe. The air duct is connected with the air pump. The reaction kettle is connected with the medicine bottle in an airtight way through a liquid guide pipe. The air pump is arranged in a mode that the air pressure in the reaction kettle can be changed, so that the medicament in the medicament bottle can enter and exit the reaction kettle based on the change of the air pressure. The solid medicine and the medicament are dissolved and mixed in the reaction kettle for reaction.

According to a preferred embodiment, the reaction vessel is provided with a motor, a drive shaft and a stirring blade. The motor is arranged on the first surface of the top of the reaction kettle. The transmission shaft penetrates through the top of the reaction kettle. The first end of the transmission shaft is connected with the motor. And the second end of the transmission shaft is arranged inside the reaction kettle and connected with the stirring sheet. The motor can drive the stirring sheet to rotate through the transmission shaft. The motor can drive the stirring sheet to stir the solution in the reaction kettle through the transmission shaft so as to enable the solution to move, and therefore solution reaction is promoted. The motor may perform rotation at variable speeds or in a step-wise manner to speed up the dissolution. This is because the inventors of the present invention found that the ordered flow inside the liquid medicine caused by the vortex flow prevents the liquid medicine from being sufficiently dissolved at a high speed.

According to a preferred embodiment, the top surface of the inner cavity of the reaction kettle is provided with a photoelectric emitter. The inner cavity ground of the reaction kettle is provided with a photoelectric receiver. With the rotation of the stirring blade, the solid drug exists in the solution in a suspended manner. Under the condition that the solid medicine is not completely dissolved, light rays emitted by the photoelectric emitter meet with the suspended solid medicine to generate catadioptric effect and then reach the photoelectric receiver. And the processing unit is used for processing the signal converted by the photoelectric receiver so as to determine whether the solid medicine is completely dissolved in the reaction kettle.

The motor can pass through the transmission shaft drives the stirring piece is to solution in the reation kettle stirs and makes solution move, and then makes the medicine in the reation kettle keep the suspended state under the effect of rivers, and when processing unit thinks "from the center to both sides be non-level at the liquid level according to the signal of oblique light path of wearing, can instruct the stirring piece by processing unit to slow down the rotation speed or carry out the rotation with step-by-step mode for accelerate dissolving. This is because the inventors of the present invention found that the ordered flow inside the liquid medicine caused by the vortex flow prevents the liquid medicine from being sufficiently dissolved at a high speed.

In the present invention, two technical challenges need to be faced in the technical scheme of determining the dissolution of the drug by detecting the optical characteristics of the drug solution under stirring rotation: firstly, even if the same medicine is dissolved in the same liquid medicine, the solution itself still has certain optical fluctuation, and it becomes a challenge to deal with the electric signal fluctuation caused by the optical signal fluctuation; secondly, in the rotation process of the medicine, physical interference caused by liquid flow shaking is a non-negligible problem, and the time required for waiting for the rotation liquid medicine to return to a static state is too long, so that the working efficiency is seriously influenced. In the invention, a plurality of parallel light paths can be arranged between a photoelectric emitter arranged on the top surface of the kettle inner cavity connected with the air duct and a photoelectric receiver arranged on the bottom surface of the kettle inner cavity, and optical fluctuation caused by the solubility of the liquid medicine is overcome through signal compensation between the parallel light paths; in addition, obliquely traversing light paths, preferably at least three obliquely traversing light paths, oblique to the parallel light paths may be provided, which form a spatial angle of 60 ° with each other to compensate for physical disturbances caused by liquid impinging on the tank sidewall. This is because physical disturbances are mostly present as turbulence-induced water flow oscillations near the tank side walls, which are usually locally sporadic and can induce a non-level liquid level from the center to the sides. The scale of the vortex can be judged by three obliquely penetrating light paths which form a space angle of 60 degrees with each other, and when the liquid level is not horizontal from the center to two sides, the processing unit disables the signal acquisition of the parallel light paths, thereby reducing unnecessary signal processing work.

According to a preferred embodiment, the top of the reaction kettle is also provided with a dosing pipe. The medicine feeding pipe is connected with the medicine feeding box. The medicine adding box can add medicines into the reaction kettle through the medicine adding pipe. The medicine adding box can ensure the air tightness in the reaction kettle by using the mode of adding medicine into the reaction kettle by the medicine adding pipe. The medicine adding box can add medicine into the reaction kettle along the kettle wall (namely the outermost side in the radial direction of the rotating liquid flow) through the medicine adding pipe, preferably, the medicine is added at one time when the liquid medicine rotates to form a vortex, and the time for forming the vortex can be judged by the processing unit according to the obliquely penetrating light path signal.

According to a preferred embodiment, the bottom of the reaction kettle is provided with a liquid guide valve. The drain valve is arranged on the outer side of the reaction kettle. The drainage valve is connected with the drainage tube. The liquid guide valve can control the connection and disconnection of the liquid guide pipe and the reaction bin. The liquid guide valve can ensure that a solution channel is unblocked under the condition that the air pump changes the air pressure in the reaction kettle to ensure that the medicament in the medicament bottle enters and exits the reaction kettle based on the air pressure change. The valve can control the connection and disconnection of the liquid guide pipe and the reaction kettle, the sealing performance of the reaction kettle can be ensured, and the interference caused by the volume change of the solution in the reaction kettle in the photoelectric detection process of the system can be further avoided. Preferably, the processing unit is capable of indicating the valve on-off based on a signal obliquely across the optical path to interfere with the generation of high speed vortices to further optimize dissolution.

According to a preferred embodiment, the reaction device further comprises a tank. The medicine adding box and the air pump are arranged on the outer surface of the box body. The medicine adding box is arranged on the outer surface of the box body, so that a user can add medicines into the medicine adding box. The air pump is arranged on the outer surface of the box body so as to facilitate air exchange. The reation kettle the medicine bottle with the drain valve is located inside can guaranteeing to dissolve the mixed reaction and go on under with external isolated environment of box. Preferably, the tank body isolates the environment of the dissolving and mixing reaction from the external environment so as to prevent external factors from polluting the liquid medicine.

According to a preferred embodiment, the cabinet is further provided with a control panel. The control panel comprises a processing unit and a man-machine interaction unit. The processing unit of the control panel is respectively in electric signal connection with the medicine adding box, the motor, the air pump and the liquid guide valve. In the case of using the device, a user can send instructions to the processing unit through the man-machine interaction unit in the control panel. The user can make the air pump make the medicament in the medicine bottle pass in and out the reation kettle based on atmospheric pressure change through the human-computer interaction unit through changing atmospheric pressure in the reation kettle. The invention sends various instructions to complete the addition, stirring, mixing and collection of medicaments through the human-computer interaction unit, thereby reducing the labor intensity of users.

According to a preferred embodiment, the box is further provided with a viewing window. The observation window is arranged on the second surface of the box body. The position of the observation window corresponds to the position of the reaction kettle. Medical staff can observe the conditions in the reaction kettle through the observation window. Medical staff can observe the air pump through the observation window, so that the medicine in the medicine bottle enters and exits the reaction kettle based on air pressure change by changing the air pressure in the reaction kettle. Preferably, in the case where the photodetection function of the reaction invention is malfunctioning, the user can judge the progress of the dissolution mixing reaction in the reaction vessel through the observation window.

According to a preferred embodiment, the box is further provided with a mounting seat. The mounting seat is arranged in the middle of the third surface of the box body. A groove is formed in the mounting seat. The groove arranged on the mounting seat is matched with the bottom of the medicine bottle. Medical staff can place the medicine bottle in the mode of the recess that sets up on the mount pad is to the medicine bottle carries out spacingly for the medicine bottle is in stable state at the reaction in-process. The mount pad can the air pump is through changing atmospheric pressure among the reation kettle makes medicament in the medicine bottle passes in and out based on atmospheric pressure changes reation kettle's in-process ensures the medicine bottle is reliable and stable, avoids the medicine bottle to shake owing to vibrations and drops.

According to a preferred embodiment, the box body is further provided with a medicine taking window. The position of the medicine taking window corresponds to the mounting seat. The medicine taking window is positioned on the second surface of the box body. One edge of the medicine taking window is superposed with the common edge of the second surface and the third surface of the box body. The medical staff can place the medicine bottle on the mounting seat through the medicine taking window to perform dissolving and mixing reaction. Medical personnel can remove the vial through the access window for subsequent use upon completion of the reaction. The medicine taking window can ensure that the air pump can ensure that the medicine in the medicine bottle enters and exits the reaction kettle based on the air pressure change through changing the air pressure in the reaction kettle, and the medicine bottle is positioned in an independent environment, so that the sanitation and the safety are ensured.

The invention also provides a reaction method, which comprises the following steps. In a first step, the second end of the catheter is attached to the bottom of the vial. And secondly, placing the medicine bottle on the mounting seat. And thirdly, opening a valve by a drainage valve to conduct the reaction kettle and the drainage tube. The air pump enters an air pumping mode, and the air in the reaction kettle is continuously pumped out by the air pump. The air pressure in the reaction kettle is continuously reduced to form a negative pressure environment, and the solvent in the medicine bottle enters the reaction kettle based on the negative pressure under the action of the negative pressure. And fourthly, under the condition that the solvent in the medicine bottle completely enters the reaction kettle, closing the valve of the liquid guide valve to block the conduction between the reaction kettle and the liquid guide pipe, and enabling the air pump to enter a closing mode to stop working. And fifthly, adding the medicine into the reaction kettle through a medicine adding pipe by the medicine adding box under the condition that the solvent enters the reaction kettle and the air pump stops working. Sixthly, preferably, the medical staff can rotate the motor at regular time or continuously through the control panel, and the motor keeps rotating, so that the stirring piece can stir the solution. And seventhly, stopping rotating the motor after the rotation time of the motor reaches the set time or manually stopping the motor by medical staff, so that the stirring piece stops stirring the solution. And eighthly, opening the liquid guide valve, enabling the air pump to enter an air injection mode, injecting external air into the reaction kettle by the air pump, and enabling the solution in the reaction kettle to flow back to the medicine bottle through the liquid guide valve and the liquid guide pipe under the action of gravity and air pressure. And step nine, the drainage valve and the air pump are closed, and the medical staff can take out the medicine bottle through the medicine taking window.

Drawings

FIG. 1 is a schematic structural view of a preferred embodiment of the present invention;

FIG. 2 is a schematic view of a preferred embodiment of the housing of the present invention;

FIG. 3 is a front view of a preferred embodiment of the present invention;

FIG. 4 is a schematic view of another preferred embodiment of the present invention

FIG. 5 is a schematic diagram of a preferred embodiment of a photoemitter of the present invention;

fig. 6 is a schematic diagram of a photoelectric receiver according to a preferred embodiment of the present invention.

List of reference numerals

100: reaction apparatus 110: a medicine adding box 111: medicine feeding pipe

120: reaction kettle 121: the motor 122: transmission shaft

123: the stirring blade 124: the photoemitter 125: photoelectric receiver

130: the medicine bottle 131: bottle cap 140: air pump

141: an air duct 150: case 151: control panel

152: the observation window 153: medicine taking window 154: mounting seat

160: the liquid guiding valve 161: liquid guiding tube

Detailed Description

The following detailed description is made with reference to fig. 1 to 6.

In the prior art, medicines and solvents are added into a reaction device through a feeding hole, and the mixed solution is collected through a discharging hole after the medicines and the solvents are dissolved and mixed to form the solution, which is very common. Because medical instruments have strict sanitary requirements, the medicine bottle containing the solvent becomes medical waste after the solvent is added into the reaction device from the feeding hole, and cannot be used for containing the mixed solution. The prior art uses the mixed reaction device to carry out under the condition that the medicine mixes, and the solvent before mixing adopts different medicine bottles to hold with the solution after the completion of mixing. The prior art ensures medical sanitation, but causes resource waste, especially waste of medicine bottles. Traditional medicine mixes is with in the medicine direct addition solvent medicine bottle, then rocks through medical staff's hand and accomplishes the mixture of medicine and solvent, though this kind of mode can not waste the medicine bottle, has increased medical staff's intensity of labour, crowds the operating time who accounts for medical staff, also is a waste to medical resources. In view of the above problems, the present invention provides a reaction apparatus that enables one vial to contain both a pre-mixing solvent and a mixed solution.

The principle behind the present invention is that the second end of the catheter is attached to the bottom of the vial, placing the vial on the mount. The liquid guide valve opens the valve to conduct the reaction kettle and the liquid guide pipe, the air pump enters an air pumping mode, air in the reaction kettle is continuously pumped out by the air pump, the air pressure in the reaction kettle is continuously reduced to form a negative pressure environment, and under the action of negative pressure, the solvent in the medicine bottle enters the reaction kettle based on the negative pressure. And under the condition that the solvent in the medicine bottle completely enters the reaction kettle, the liquid guide valve closes the valve to block the conduction between the reaction kettle and the liquid guide pipe, and the air pump enters a closing mode to stop working. And under the condition that the solvent enters the reaction kettle and the air pump stops working, the medicine adding box adds the medicine into the reaction kettle through the medicine adding pipe. Preferably, the medical staff can make the motor rotate regularly or rotate uninterruptedly continuously through the control panel, the motor keeps rotating, and then make the stirring piece stir the solution. The motor stops rotating after the rotation time reaches the set time or the medical staff manually stops rotating the motor, so that the stirring piece stops stirring the solution. And opening the liquid guide valve, enabling the air pump to enter an air injection mode, enabling the air pump to inject external air into the reaction kettle, and enabling the solution in the reaction kettle to flow back to the medicine bottle through the liquid guide valve and the liquid guide pipe under the action of gravity and air pressure. The liquid guide valve and the air pump are closed, and the medical staff can take out the medicine bottle through the medicine taking window. The invention enables one medicine bottle to contain both the solvent before mixing and the mixed solution.

The invention successfully solves the problem that the traditional medicine mixing needs to be manually shaken by medical staff; the automatic addition and collection of medicines can be realized, and the labor intensity of medical staff is reduced; and can make a medicine bottle can enough hold the solvent before mixing, can hold the solution that mixes again to practice thrift medical resources.

Example 1

The present embodiment discloses a reaction apparatus 100. The reaction apparatus 100 includes a drug adding box 110, a reaction kettle 120, a drug bottle 130, an air pump 140, a box 150 and a liquid guide valve 160.

The reaction apparatus 100 includes at least a reaction tank 120. The top of the reaction kettle 120 is provided with a gas-guide tube 141. The air duct 141 is connected to the air pump 140. The reaction vessel 120 is hermetically connected to the vial 130 via a catheter 161. The air pump 140 is provided in such a manner that the medicine in the medicine bottle 130 can be moved into and out of the reaction kettle 120 based on the change in the air pressure by changing the air pressure in the reaction kettle 120.

Preferably, the reaction kettle 120 further comprises a motor 121 capable of controlling the stirring sheet 123 to rotate through the transmission shaft 122. The motor 121 can be regulated by the processing unit.

Preferably, the dosing cassette 110 is located outside the reaction kettle 120 and on top of the box 150. The pharmaceutical pig 130, which is located at the top of the box 150, can feed solid pharmaceutical into the reaction vessel through the drug inlet tube 131, which has its opening close to the top surface of the inner cavity of the reaction vessel 120, so as to inject the pharmaceutical in the region of the maximum circumferential velocity of the liquid flow.

Preferably, the bottom of the reaction vessel 120 is provided with a liquid guide valve 160 and a liquid guide tube 161 connected to the liquid guide valve 160. The liquid guiding valve 160 can control the on-off of the liquid guiding pipe 161 and the reaction kettle 120 to adjust the liquid level in the reaction kettle 120.

Preferably, the air pump 140 is placed on top of the outer surface of the case 150 to facilitate air exchange.

Preferably, the box 150 is provided with a control panel 151 near the medicine adding box 110 for issuing work orders to the reaction device.

Preferably, the box 150 is provided with an observation window 152 at a position flush with the reaction kettle 120 for observing the reaction kettle 120.

Preferably, a mounting seat 154 is provided on the bottom surface of the interior of the case 150, and the mounting seat 154 is configured with a groove for placing the medicine bottle 130.

Preferably, the box 150 is provided with a medicine taking window 153 near the mounting seat 154 for taking and placing the medicine bottle 130.

Preferably, the reaction kettle 120 is provided with a motor 121, a driving shaft 122 and a stirring blade 123. Motor 121 is disposed on the top first surface of reaction vessel 120. The drive shaft 122 extends through the top of the reaction vessel 120. The first end of the transmission shaft 122 is connected to the motor 121. The second end of the transmission shaft 122 is connected with the stirring plate 123 inside the reaction kettle 120. The motor 121 can rotate the stirring blade 123 through the transmission shaft 122. The reaction kettle 120 further comprises a motor 121 and a transmission shaft 122, wherein the motor 121 can control the stirring sheet 123 to rotate through the transmission shaft 122, and the motor 121 can be adjusted in speed through the processing unit.

Preferably, the top of the reaction kettle 120 is further provided with a dosing pipe 111. The dosing tube 111 is connected to the dosing cassette 110. The medicine adding box 110 can add a medicine to the inside of the reaction vessel 120 through the medicine adding pipe 111. Preferably, a dosing pipe 111 is arranged at the top of the reaction kettle 120 and close to the side wall of the reaction kettle 120. Dosing block 110 is capable of adding a drug to reaction vessel 120 along the vessel wall (i.e., radially outermost in the rotational flow) through dosing tube 111.

Preferably, the bottom of the reaction kettle 120 is provided with a liquid guide valve 160. The liquid guide valve 160 is disposed outside the reaction kettle 120. The catheter valve 160 is connected to a catheter 161. The liquid guide valve 160 can control the connection and disconnection between the liquid guide tube 161 and the reaction chamber.

Preferably, the reaction apparatus further comprises a tank 150. The medicine adding box 110 and the air pump 140 are disposed on the outer surface of the case 150. The dosing box 110 is disposed on the outer surface of the box 150 to facilitate a user to add a medicine into the dosing box 110. The air pump 140 is provided on the outer surface of the case 150 to facilitate air exchange. The reaction kettle 120, the medicine bottle 130 and the liquid guiding valve 160 are located inside the box 150 to ensure that the dissolving and mixing reaction is performed in an environment isolated from the outside.

Preferably, the cabinet 150 is further provided with a control panel 151. The control panel 151 includes a processing unit and a human-machine interaction unit. The processing unit of the control panel 151 is electrically connected with the medicine adding box 110, the motor 121, the air pump 140 and the liquid guiding valve 160 respectively. In the case of using the present device, the user can send instructions to the processing unit through the human-machine interaction unit in the control panel 151.

Preferably, the case 150 is further provided with a viewing window 152. The observation window 152 is provided at the second surface of the case 150. The position of the observation window 152 corresponds to the position of the reaction vessel 120. Medical personnel can observe the conditions in reaction vessel 120 through observation window 152.

Preferably, the case 150 is further provided with a mount 154. The mount 154 is provided at the middle of the third surface of the case 150. A recess is provided in the mounting block 154. The mounting seat 154 is provided with a groove adapted to the bottom of the vial 130. The medical staff can position the vial 130 by placing the vial 130 in a recess provided in the mounting seat 154 so that the vial 130 is in a stable state during the reaction process.

Preferably, the case 150 is further provided with a medicine taking window 153. The position of the medicine dispensing window 153 corresponds to the mounting seat 154. The medicine taking window 153 is located on the second surface of the case 150. One edge of the dispensing window 153 coincides with a common edge of the second and third surfaces of the case 150. Medical personnel can place the vial 130 onto the mounting seat 154 through the access window 153 for a dissolution mixing reaction. Upon completion of the reaction, the medical personnel can remove the vial 130 through the access window 153 for subsequent use.

Fig. 1 is a schematic structural diagram of the present embodiment. The case 150 is used to house the devices. Preferably, the medicine adding box 110 and the air pump 140 are disposed on the outer surface of the case 150. Preferably, the reaction vessel 120, the vial 130 and the drain valve 160 are located inside the box 150. The dosing box 110 is disposed on a first surface of the case 150. Preferably, the dosing cassette 110 is disposed on a first surface of the housing 150 away from the edge. The air pump 140 is disposed on the first surface of the case 150, as in the medicine adding case 110. Preferably, the air pump 140 is disposed at a position near the edge of the first surface of the case 150.

The medicine adding box 110 stores solid medicines to be mixed for dissolution. Preferably, the solid drug is a powder drug. The dosing box 110 is connected with the reaction kettle 120 through a dosing pipe 111. Preferably, the first end of the dosing tube 111 passes through the first surface of the case 150 to be connected to the dosing block 110. Preferably, the second end of the dosing tube 111 is connected to the inside of the reaction vessel 120 through the wall of the reaction vessel 120. Preferably, the medicine adding cassette 110 can deliver the stored solid medicine into the reaction kettle 120 through the medicine adding pipe 111.

The air pump 140 is connected to the reaction kettle 120 through an air duct 141. Preferably, the first end of the gas-guide tube 141 passes through the first surface of the box 150 to be connected with the reaction vessel 120. Preferably, the second end of the gas-guide tube 141 passes through the wall of the reaction kettle 120 and is connected to the inside of the reaction kettle 120. Preferably, the gas-guide tube 141 is L-shaped. The gas pump 140 can pump gas out of the reaction vessel 120 through the gas guide tube 141 or inject gas into the reaction vessel 120.

Preferably, reaction vessel 120 is made of a transparent material. Preferably, reaction vessel 120 is generally approximately cylindrical in shape. Preferably, the bottom of the reaction kettle 120 is provided with a liquid guide valve 160. Preferably, the bottom of the reaction kettle 120 is arranged in a funnel shape. Preferably, the liquid guiding valve 160 is disposed at the central position of the outer bottom of the reaction kettle 120. The reaction vessel 120 is connected to a liquid guide tube 161 via a liquid guide valve 160. Preferably, a first end of the catheter 161 is connected to the catheter valve 160. Preferably, the second end of the catheter 161 is connected to the vial 130. Preferably, the gas-guide tube 141 and the dosing tube 111 both pass through the first surface of the reaction kettle 120.

The medicine bottle 130 is provided with a bottle cap 131. Preferably, the cap 131 is secured to the vial 130 such that the interior of the vial 130 forms a closed environment. Preferably, the center of the bottle cap 131 is made of an elastic material. Preferably, the center of the bottle cap 131 is made of rubber. Preferably, the catheter 161 passes centrally through the cap 131. Preferably, the second end of the catheter 161 is attached to the bottom of the vial 130. Preferably, the second end port of the catheter 161 is reinforced to facilitate puncturing the central portion of the cap 131. Preferably, since the center of the cap 131 is made of rubber, the contact portion of the catheter 161 and the cap 131 can be tightly attached to form air tightness.

A motor 121 is disposed outside the first surface of the reaction kettle 120. Preferably, the motor 121 is disposed at the center of the first surface of the reaction vessel 120. The motor 121 is connected to a drive shaft 122. The driving shaft 122 is provided with a plurality of stirring blades 123. Preferably, the stirring blade 123 and the driving shaft 122 together constitute a stirring assembly in a shape of approximately a fishbone. Preferably, drive shaft 122 passes through a first surface of reaction vessel 120. Preferably, a first end of the transmission shaft 122 is connected with the motor 121. Preferably, stirring blades 123 are provided on the driving shaft 122 with a gap. Preferably, the stirring blades 123 disposed on the transmission shaft 122 are equally spaced. Preferably, the stirring blade 123 provided on the shaft body of the driving shaft 122 has a rectangular shape. Preferably, the second end of the driving shaft 122 is provided with a stirring blade 123 with a shape matching with the bottom shape of the reaction kettle 120.

Fig. 2 is a schematic view of the case 150 of the present embodiment. Fig. 3 is a front view of the present embodiment. As shown in fig. 2 to 3, the box 150 is further provided with a control panel 151, an observation window 152, a medicine taking window 153, and a mounting seat 154. Preferably, the observation window 152 is provided at the second surface of the case 150. Preferably, the viewing window 152 is made of a transparent material. Preferably, the viewing window 152 is located at the middle of the second surface of the case 150. Preferably, the position of the observation window 152 corresponds to the position of the reaction vessel 120. Preferably, medical personnel can view the conditions in the reaction vessel 120 through the viewing window 152.

The bottom of the case 150 is provided with a mounting seat 154. Preferably, the bottom of the case 150 is the third surface of the case 150. Preferably, the mounting 154 is located inside the case 150. Preferably, the mount 154 is disposed at a middle portion of the third surface of the case 150. A recess is provided in the mounting block 154. Preferably, the mounting seat 154 is provided with a groove that fits the bottom of the vial 130. Preferably, the medical staff can position the vial 130 by placing the vial 130 in a recess provided in the mounting seat 154 so that the vial 130 is in a stable state during the reaction.

The box 150 is also provided with a medicine taking window 153. Preferably, the medicine taking window 153 is provided on the second surface of the case 150. Preferably, the position of the medicine taking window 153 corresponds to the mounting seat 154. Preferably, the medicine taking window 153 is located on the second surface of the case 150, and one side of the medicine taking window 153 coincides with a common side of the second surface and the third surface of the case 150. Preferably, medical personnel can place the vial 130 through the access window 153 onto the mounting cup 154 for a dissolution mixing reaction. Preferably, upon completion of the reaction, the medical personnel can remove the vial 130 through the access window 153 for subsequent use.

The cabinet 150 is provided with a control panel 151. The control panel 151 includes a processing unit and a human-machine interaction unit. Preferably, the medical staff can send instructions to the processing unit through the man-machine interaction unit of the control panel 151 in case of using the reaction device 100 provided by the present invention. Preferably, the processing unit of the control panel 151 is in electrical signal connection with the medicated box 110, the motor 121, the air pump 140 and the drain valve 160, respectively.

Preferably, the processing unit of the control panel 151 can control the opening and closing of the liquid guide valve 160 by sending a signal to the liquid guide valve 160. Preferably, the processing unit of the control panel 151 is capable of controlling the operation mode of the air pump 140 by sending a signal to the air pump 140. Preferably, the operation mode of the air pump 140 includes an air suction mode, an air injection mode, and an off mode.

Preferably, the processing unit of the control panel 151 is capable of sending a medicating signal to the medicating cartridge 110. Preferably, the dosing box 110 adds the solid medicine to the reaction kettle 120 through the dosing pipe 111 upon receiving the dosing signal. Preferably, an electronic control valve is arranged at the connection position of the dosing box 110 and the dosing pipe 111. Preferably, the medicated cartridge 110 is electrically connected to the processing unit. Preferably, an electronic valve is arranged at the joint of the dosing box 110 and the dosing tube 111. Preferably, the processing unit is capable of controlling the addition of the solid medicine in the reaction kettle 120 by controlling the opening and closing of the electronic control valve in the medicine adding box 110.

Preferably, the processing unit is electrically connected to the motor 121. The processing unit is able to control the operating state of the motor 121 by sending a start/stop signal to the motor 121. Preferably, the processing unit is able to send an activation signal to the motor 121. Preferably, the motor 121 is operated at a constant rotation speed upon receiving the start signal. Preferably, the motor 121 drives the stirring blade 123 to rotate through the transmission shaft 122, and since the rotation speed of the motor 121 is constant, the rotation speed of the stirring blade 123 is constant and the same as the rotation speed of the motor 121. The stirring blade 123 rotates in the reaction kettle 120 to stir the solution in the reaction kettle, thereby promoting the dissolution mixing reaction of the medicine and the solvent. Preferably, the processing unit is able to send a stop signal to the motor 121. Preferably, the motor 121 stops rotating when receiving the stop signal, so that the stirring blade 123 stops stirring.

Preferably, after the medical staff connects the vial 130 containing the solvent to the catheter 161 in the case of using the reaction device 100 provided in this embodiment, the medical staff is placed on the groove of the mounting seat 154 through the medicine taking window 153. Medical personnel send add solvent instructions to the processing unit through the control panel 151. Preferably, the processing unit sends an open signal to the liquid guide valve 161 when receiving the instruction to add the solvent, and simultaneously sends a suction signal to the air pump 140. Preferably, the liquid guiding valve 161 is opened to conduct the reaction kettle 120 and the liquid guiding tube 161 when receiving the opening signal. Preferably, in case the air pump 140 receives the air pumping signal, the air pump 140 enters the air pumping mode. Preferably, the gas pump 140 in the pumping mode continuously pumps the gas out of the reaction kettle 120. Preferably, since the gas in the reaction kettle 120 is continuously pumped out by the gas pump 140, the gas pressure in the reaction kettle 120 is continuously reduced, and a negative pressure environment is formed. Under the action of the negative pressure, the solvent in the medicine bottle 130 enters the reaction kettle 120 based on the negative pressure. Preferably, in case the solvent in the vial 130 completely enters the reaction vessel 120, the processing unit sends a closing signal to the liquid guide valve 161. Preferably, the liquid guiding valve 161 closes to block the conduction between the reaction kettle 120 and the liquid guiding tube 161 when receiving the closing signal. Preferably, the processing unit sends a closing signal to the air pump 140 when the liquid guide valve 161 closes to block the conduction between the reaction vessel 120 and the liquid guide tube 161. Preferably, in case that the air pump 140 receives the turn-off signal, the air pump 140 enters the turn-off mode and stops operating. Preferably, in the case where the solvent has entered the reaction kettle 120 and the air pump 140 is stopped, the medicine adding box 110 adds the medicine to the reaction kettle 120 through the medicine adding pipe 111. Preferably, the medicine adding box 110 adds the medicine into the reaction kettle 120 through the medicine adding pipe 111 in a powder shape. Preferably, the motor 121 is always in a rotating state during the process of adding the medicine into the reaction vessel 120 through the medicine adding box 110 via the medicine adding pipe 111. Since the motor 121 is connected to the stirring blade 123 through the transmission shaft 122, when the motor 121 rotates, the stirring blade 123 is also in a rotating state, and the rotation speed of the stirring blade 123 is constant and the same as the rotation speed of the motor 121. Preferably, in the case that the medicine adding box 110 is put into the reaction vessel 120, the motor 121 is in a rotating state, and the stirring blade 123 is also in a rotating state. Preferably, during the process that the medicine adding box 110 adds the solid medicine into the reaction kettle 120 through the medicine adding pipe 111, the stirring sheet 123 continuously stirs the solvent in the reaction kettle 120 to promote the dissolution mixing reaction of the solid medicine and the solvent.

Preferably, the medicated box 120 closes the electronic valve upon completion of the addition of the drug to the reaction vessel 120. Preferably, in the case that the medicine adding box 120 finishes adding the medicine into the reaction kettle 120, the motor 121 is still rotated, and the stirring blade 123 keeps stirring the solution. Preferably, the medical staff can set the time for the stirring blade 123 to stir through the man-machine interaction unit of the control panel 151. Preferably, the medical staff can set the mixing time of 1 to 999 seconds through the man-machine interaction unit of the control panel 151. Preferably, the medical staff transmits the set mixing time data signal to the processing unit through the man-machine interaction unit of the control panel 151, and the processing unit controls the motor 121 to rotate the set mixing time upon receiving the mixing time data signal. Preferably, the motor 121 stops rotating when the rotation time period reaches a set time.

Preferably, the medical staff can cause the motor 121 to rotate continuously and uninterruptedly through the control panel 151. Preferably, the medical professional can keep the motor 121 rotating through the control panel 151, thereby causing the stirring blade 123 to stir the solution. When the medical staff thinks the medicine is completely dissolved and mixed, the medical staff can stop the rotation of the motor 121 and further stop the stirring of the solution by the stirring blade 123 through the control panel 151.

Preferably, the top surface of the inner cavity of the reaction kettle 120 is provided with a photoelectric emitter 124. The photoelectric receiver 125 is disposed on the bottom surface of the inner cavity of the reaction kettle 120. The photo receiver 125 is in electrical signal connection with the processing unit. Preferably, the processing unit is capable of receiving an electrical signal generated by the photoelectric receiver 125 converting the received optical signal. With the rotation of the stirring blade 123, the solid medicine exists in the solution in a suspended manner. In the case that the solid medicine is not completely dissolved, the light emitted from the photo emitter 124 meets the suspended solid medicine to generate refraction and reflection, and then reaches the photo receiver 125. The processing unit processes the signal converted by the photoelectric receiver 125 to determine whether the solid medicine is completely dissolved in the reaction kettle 120.

Fig. 5 is a schematic diagram of a preferred embodiment of the photoemitter of the present invention. Fig. 6 is a schematic diagram of a photoelectric receiver according to a preferred embodiment of the present invention. Preferably, at least three of the diagonally traversing optical paths are at a spatial angle of 60 ° with respect to each other to compensate for physical disturbances caused by liquid impinging on the tank sidewall. Preferably, the top surface of the inner cavity of the reaction kettle 120 is provided with three inclined photoemitters 124 of the photoemitters 124. Preferably, photoemitters 124 are comprised of emitter heads arranged in a circular array. Preferably, the photoemitter 126 is designed to be watertight, so as to ensure normal operation under water. Preferably, the photoelectric receiver 125 is disposed on the bottom surface of the inner cavity of the reaction kettle 120. Preferably, the photovoltaic receiver 125 is composed of a plurality of photovoltaic semiconductors abutting against one another. Preferably, the photo-receivers 125 are arranged in a circular ring shape. In the case where the mixing of the solid medicine and the solvent in the reaction tank 120 is completed, the resultant solution can be collected. Preferably, in the case that the mixing of the solid medicine and the solvent in the reaction kettle 120 is completed, the motor 121 stops rotating, and thus the stirring blade 123 stops stirring the solution. Preferably, the processing unit sends an opening signal to the liquid directing valve 160. Preferably, the liquid guiding valve 161 is opened to conduct the reaction kettle 120 and the liquid guiding tube 161 when receiving the opening signal. Preferably, the processing unit sends a gas injection signal to the air pump 140 with the bleed valve 161 open. Preferably, the air pump 140 enters the air injection mode upon receiving the air injection signal by the air pump 140. Preferably, the air pump 140 injects the external air into the reaction vessel 120. As the gas is continuously injected into the reaction vessel 120, the pressure of the gas in the reaction vessel 120 increases. The solution in the reaction kettle 120 flows back to the medicine bottle 130 through the liquid guide valve 160 and the liquid guide tube 161 under the action of gravity and air pressure.

Preferably, the processing unit sends a close signal to the liquid guide valve 161 in case the solution in the reaction tank 120 completely flows into the vial 130. Preferably, the liquid guiding valve 161 closes to block the conduction between the reaction kettle 120 and the liquid guiding tube 161 when receiving the closing signal. Preferably, the processing unit sends a closing signal to the air pump 140 when the liquid guide valve 161 closes to block the conduction between the reaction vessel 120 and the liquid guide tube 161. Preferably, in case that the air pump 140 receives the turn-off signal, the air pump 140 enters the turn-off mode and stops operating. Preferably, when the drainage valve 161 is closed and the air pump 140 is stopped, the medical staff member can take out the medicine bottle 130 through the medicine taking window 153.

Example 2

The present embodiment discloses a reaction apparatus 100. The apparatus of this embodiment may be implemented by the apparatus of the present invention and/or other alternative components. For example, the method disclosed in the present embodiment is implemented by using various components in the apparatus of the present invention. The preferred embodiments of the present invention are described in whole and/or in part in the context of other embodiments, which can supplement the present embodiment, without resulting in conflict or inconsistency.

The reaction apparatus 100 of this example is shown in FIG. 4. The reaction apparatus 100 is provided with a plurality of reaction tanks 120. Preferably, three reaction vessels 120 are provided in this embodiment. Preferably, the case 150 of the reaction apparatus 100 of the present embodiment is provided with a plurality of observation windows 152. Preferably, the present embodiment is provided with three observation windows 152. Preferably, the case 150 of the reaction apparatus 100 of the present embodiment is provided with a plurality of drug taking windows 153. Preferably, the present embodiment is provided with three medicine taking windows 153. Preferably, each reaction kettle 120 is connected with a dosing pipe 111, a dosing box 110, an air duct 141, an air pump 140 and a drainage valve 160. Preferably, the medicine adding box 110 and the air pump 140 are disposed on the outer surface of the case 150. Preferably, the reaction vessel 120, the vial 130 and the drain valve 160 are located inside the box 150. The dosing box 110 is disposed on a first surface of the case 150. The air pump 140 is disposed on the first surface of the case 150, as in the medicine adding case 110. The dosing box 110 is connected with the reaction kettle 120 through a dosing pipe 111. Preferably, the first end of the dosing tube 111 passes through the first surface of the case 150 to be connected to the dosing block 110. Preferably, the second end of the dosing pipe 111 passes through the bin wall of the reaction kettle 120 and is connected to the inside of the reaction kettle 120. The air pump 140 is connected to the reaction kettle 120 through an air duct 141. Preferably, the first end of the gas guide tube 141 passes through the first surface of the case 150 to be connected to the reaction vessel 120. Preferably, the second end of the gas-guide tube 141 passes through the bin wall of the reaction kettle 120 and is connected to the inside of the reaction kettle 120. Preferably, the gas-guide tube 141 is L-shaped. The gas pump 140 can pump gas out of the reaction vessel 120 through the gas pipe 141 or inject gas into the reaction vessel 120. Preferably, reaction vessel 120 is made of a transparent material. Preferably, reaction vessel 120 is generally approximately cylindrical in shape. Preferably, the bottom of the reaction kettle 120 is provided with a liquid guide valve 160. Preferably, the bottom of the reaction kettle 120 is arranged in a funnel shape. Preferably, the liquid guiding valve 160 is disposed at the center of the outer bottom of the reaction vessel 120. The reaction vessel 120 is connected to a liquid guide tube 161 via a liquid guide valve 160. Preferably, a first end of the catheter 161 is connected to the catheter valve 160. Preferably, the second end of the catheter 161 is connected to the vial 130. Preferably, the gas-guide tube 141 and the dosing tube 111 both pass through the first surface of the reaction vessel 120. The medicine bottle 130 is provided with a bottle cap 131. Preferably, the cap 131 is secured to the vial 130 such that the interior of the vial 130 forms a closed environment. Preferably, the center of the bottle cap 131 is made of an elastic material. Preferably, the center of the bottle cap 131 is made of rubber. Preferably, the catheter 161 passes centrally through the cap 131. Preferably, the second end of the catheter 161 is attached to the bottom of the vial 130. Preferably, the second end port of the catheter 161 is reinforced to facilitate puncturing the central portion of the cap 131. Preferably, since the center of the cap 131 is made of rubber, the contact portion of the catheter 161 and the cap 131 can be tightly attached to form air tightness. A motor 121 is disposed outside the first surface of the reaction kettle 120. Preferably, the motor 121 is disposed at the center of the first surface of the reaction vessel 120. The motor 121 is connected to a drive shaft 122. The driving shaft 122 is provided with a plurality of stirring blades 123. Preferably, the stirring blade 123 and the driving shaft 122 together constitute a stirring assembly in a shape of approximately a fishbone. Preferably, the drive shaft 122 passes through a first surface of the reaction vessel 120. Preferably, a first end of the transmission shaft 122 is connected with the motor 121. Preferably, stirring blades 123 are provided on the driving shaft 122 with a gap. Preferably, the stirring blades 123 disposed on the transmission shaft 122 are equally spaced. Preferably, the stirring blade 123 provided on the shaft body of the driving shaft 122 has a rectangular shape. Preferably, the second end of the driving shaft 122 is provided with a stirring blade 123 with a shape matching with the bottom shape of the reaction kettle 120. Preferably, the observation window 152 is provided at the second surface of the case 150. Preferably, the viewing window 152 is made of a transparent material. Preferably, the observation window 152 is located at the middle of the second surface of the case 150. Preferably, the position of the observation window 152 corresponds to the position of the reaction vessel 120. Preferably, medical personnel can view the conditions in the reaction vessel 120 through the viewing window 152.

The box 150 is also provided with a medicine taking window 153. Preferably, the medicine taking window 153 is provided on the second surface of the case 150. Preferably, the position of the medicine taking window 153 corresponds to the mounting seat 154. Preferably, the medicine taking window 153 is located on the second surface of the case 150, and one side of the medicine taking window 153 coincides with a common side of the second surface and the third surface of the case 150. Preferably, medical personnel can place the vial 130 through the access window 153 onto the mounting cup 154 for a dissolution mixing reaction. Preferably, upon completion of the reaction, the medical personnel can remove the vial 130 through the access window 153 for subsequent use. The cabinet 150 is provided with a control panel 151. The control panel 151 includes a processing unit and a human-machine interaction unit. Preferably, the medical staff can send instructions to the processing unit through the man-machine interaction unit of the control panel 151 in case of using the reaction device 100 provided by the present invention. Preferably, the processing unit of the control panel 151 is electrically connected to each of the medicine adding box 110, the motor 121, the air pump 140 and the drain valve 160, respectively.

Preferably, the medical staff can send instructions to the processing unit through the man-machine interaction unit of the control panel 151, and the processing unit sends signals to the reaction kettle 120 and the device connected to the reaction kettle 120, so that the reaction kettle 120 performs the dissolution mixing reaction. Preferably, medical staff can make each of the three reaction vessels 120 perform the dissolution mixing reaction through the control panel 151.

Example 3

This example discloses a reaction method. The method of this embodiment may be implemented by the apparatus of the present invention and/or other alternative components. For example, the method disclosed in the present embodiment is implemented by using various components in the apparatus of the present invention. The preferred embodiments of the present invention are described in whole and/or in part in the context of other embodiments, which can supplement the present embodiment, without resulting in conflict or inconsistency.

This example discloses a method for promoting drug dissolution mixing reactions. The method of the embodiment comprises the following steps.

S100: the second end of the catheter 161 is connected to the bottom of the vial 130;

s200: placing the vial 130 on the mount 154;

s300: the liquid guide valve 161 opens a valve to conduct the reaction kettle 120 and the liquid guide tube 161, the air pump 140 enters an air pumping mode, air in the reaction kettle 120 is continuously pumped out by the air pump 140, the air pressure in the reaction kettle 120 is continuously reduced to form a negative pressure environment, and under the action of negative pressure, the solvent in the medicine bottle 130 enters the reaction kettle 120 based on the negative pressure;

s400: when the solvent in the medicine bottle 130 completely enters the reaction kettle 120, the liquid guide valve closes the valve to block the conduction between the reaction kettle 120 and the liquid guide tube 161, and the air pump 140 enters a closing mode to stop working;

s500: in the case where the solvent has entered the reaction kettle 120 and the air pump 140 has stopped operating, the medicine adding box 110 adds the medicine to the reaction kettle 120 through the medicine adding pipe 111;

s600: preferably, the medical staff can make the motor 121 rotate at regular time or continuously and uninterruptedly through the control panel 151, the motor 121 keeps rotating, and then the stirring blade 123 stirs the solution;

s700: the motor 121 stops rotating after the rotation time of the motor 121 reaches a set time or medical staff manually stops rotating the motor 121, so that the stirring piece 123 stops stirring the solution;

s800: the liquid guide valve 161 is opened, the air pump 140 enters the air injection mode, the air pump 140 injects the external air into the reaction kettle 120, and the solution in the reaction kettle 120 flows back to the medicine bottle 130 through the liquid guide valve 160 and the liquid guide tube 161 under the action of gravity and air pressure;

s900: the drain valve 161 and the air pump 140 are closed and the medical professional can remove the vial 130 through the access window 153.

Preferably, the method for promoting solution reaction provided by this embodiment adopts the apparatuses disclosed in embodiment 1 and embodiment 2, and repeated descriptions are omitted.

It should be noted that the above-mentioned embodiments are exemplary, and that those skilled in the art, having benefit of this disclosure, may devise various solutions which are within the scope of this disclosure and are within the scope of the invention. It should be understood by those skilled in the art that the present specification and figures are illustrative only and are not limiting upon the claims. The scope of the invention is defined by the claims and their equivalents.

Claims

1. A reaction device at least comprises a reaction kettle (120) and a box body (150), and is characterized in that,

the top of the reaction kettle (120) is provided with an air duct (141), the air duct (141) is connected with an air pump (140), the reaction kettle (120) is connected with the medicine bottle (130) in an airtight way through a liquid guide pipe (161),

the air pump (140) is arranged in a mode that the medicine in the medicine bottle (130) can enter and exit the reaction kettle (120) based on the change of the air pressure by changing the air pressure in the reaction kettle (120);

the reaction kettle (120) further comprises a motor (121) capable of controlling the stirring sheet (123) to rotate through a transmission shaft (122), wherein the motor (121) can be regulated through a processing unit;

a photoelectric emitter (124) is arranged on the top surface of the inner cavity of the reaction kettle (120), a photoelectric receiver (125) is arranged on the bottom surface of the inner cavity of the reaction kettle (120), and a plurality of parallel light paths are arranged between the photoelectric emitter (124) and the photoelectric receiver (125);

at least three obliquely penetrating light paths are arranged in the device in an oblique mode to be parallel to the parallel light paths, and the obliquely penetrating light paths form a space angle of 60 degrees;

under the condition that the stirring sheet (123) rotates, solid medicines exist in a suspended mode in a solution, under the condition that the solid medicines are not completely dissolved, light rays emitted by the photoelectric emitter (124) meet the suspended solid medicines to generate refraction and reflection and then reach the photoelectric receiver (125), and the processing unit processes signals converted by the photoelectric receiver (125) so as to determine whether the solid medicines are completely dissolved in the reaction kettle (120).

2. The reaction device according to claim 1, wherein the dosing box (110) is arranged outside the reaction kettle (120) and on the top of the box body (150), wherein the dosing box (110) on the top of the box body (150) can feed solid medicines into the reaction kettle through a dosing pipe (111) with an opening close to the top surface of the inner cavity of the reaction kettle (120) so as to feed the medicines in the region of the maximum circumferential velocity of the liquid flow.

3. The reaction device according to claim 1, wherein a liquid guide valve (160) and a liquid guide pipe (161) connected with the liquid guide valve (160) are arranged at the bottom of the reaction kettle (120), wherein the liquid guide valve (160) can control the liquid guide pipe (161) and the reaction kettle (120) to be switched on and off to adjust the liquid level in the reaction kettle (120).

4. The reaction apparatus according to claim 1, wherein the air pump (140) is placed on top of the outer surface of the tank (150) to facilitate gas exchange.

5. The reaction apparatus according to claim 2, wherein a control panel (151) is provided to the case (150) near the loading cassette (110) for issuing a work order to the reaction apparatus.

6. The reactor apparatus according to claim 2, wherein the tank (150) is provided with an observation window (152) at a position flush with the reaction vessel (120) for observing the reaction vessel (120).

7. The reaction device of claim 2, wherein a mounting seat (154) is provided on the inner bottom surface of the housing (150), and the mounting seat (154) is provided with a groove for placing the vial (130).

8. The reaction device of claim 7, wherein the housing (150) is provided with a drug access window (153) adjacent to the mounting seat (154) for accessing the drug vial (130).

9. A method for carrying out a reaction by using the reaction device of any one of claims 1 to 8, wherein the liquid guide valve (160) is opened to conduct the reaction kettle (120) and the liquid guide tube (161), the air pump (140) enters an air pumping mode, air in the reaction kettle (120) is continuously pumped out by the air pump (140), the air pressure in the reaction kettle (120) is continuously reduced to form a negative pressure environment, and under the action of the negative pressure, the solvent in the medicine bottle (130) enters the reaction kettle (120) based on the negative pressure; the air pump (140) enters an air injection mode, the air pump (140) injects outside air into the reaction kettle (120), and the solution in the reaction kettle (120) flows back to the medicine bottle (130) through the liquid guide valve (160) and the liquid guide pipe (161) under the action of gravity and air pressure.