CN113521136A

CN113521136A - Composition for skin whitening and wrinkle removal

Info

Publication number: CN113521136A
Application number: CN202110891876.XA
Authority: CN
Inventors: 梁山露
Original assignee: Shanghai Kaida Biotechnology Co ltd
Current assignee: Shanghai Kaida Biotechnology Co ltd
Priority date: 2021-08-04
Filing date: 2021-08-04
Publication date: 2021-10-22

Abstract

The present invention relates to a composition useful for skin whitening and wrinkle reduction. The beverage comprises, by weight, 5.2-42 parts of concentrated melon powder, 10-25 parts of zinc-rich yeast powder, 0-10 parts of acerola powder, 0-10 parts of sea buckthorn fruit powder, 0-5 parts of concentrated acerola berry juice powder, 0-5 parts of liquorice, 0-5 parts of lycopene and 30-66 parts of auxiliary materials; the adjuvants are more than one of isomalt, sorbitol, microcrystalline cellulose, silicon dioxide, and magnesium stearate.

Description

Composition for skin whitening and wrinkle removal

The technical field is as follows:

the present invention relates to a composition useful for skin whitening and wrinkle reduction.

Background art:

in recent years, under the promotion of 'economy of color value', the types of skin care, color cosmetics, oral beauty and the like related to the color value are increasingly concerned by consumers, and the trillion-level consumption increase of related markets is driven.

In Asian market, "white" always ranks first, "whitening" always is the invariable subject in the beauty market, possessing enormous market demand. The traditional whitening modes such as physical masking, frosting and exfoliating, fruit acid corrosion and the like are difficult to gain market increment, particularly some whitening skin care products adopting chemical substances such as mercury salt with whitening effect, hydroquinone with freckle removing effect and the like can rapidly become white in a short period, but the long-term use can cause contact dermatitis or permanent decoloration and other adverse effects, the use of the whitening skin care products is forbidden in many countries, the safe and effective oral beauty market is emphasized, and the future development potential is huge.

The mainstream solutions in the market at present are in the directions of medical beauty, skin care product use, oral administration and the like. Because some apparatuses and intervention methods used in medicine and beauty may have some damages to human body, and the cost is high, the audiences are few, and the skin care product can only improve the skin condition from the surface, and has very limited effect on the deep nutrition of the skin.

According to the data of intelligent research and consultation, the consumption acceleration rate of the oral beautifying is far higher than the average acceleration rate of various types on the line, the consumption number and the average consumption amount of people for the on-line oral beautifying in recent years are increased year by year, and the consumers have great demands on the oral beautifying and whitening products.

In spite of the current development state of the oral beauty industry, collagen occupies most markets, but is still in the category of' reinforcing the skin, can only play some functions of partially improving wrinkles, and lacks a mature scheme of integrated oral beauty. Therefore, the development of a product which has the functions of whitening, removing wrinkles and improving skin health is urgently needed.

The invention content is as follows:

the invention aims at the problems, provides a composition which is beneficial to skin whitening and wrinkle removal, and aims to develop a product which can be orally taken to whiten and effectively remove wrinkles, promote the synthesis of collagen fibers, improve the elasticity of skin, inhibit the activity of tyrosinase and improve the brightness of the skin.

In order to achieve the purpose, the invention adopts the following technical scheme, and the components and parts by weight of the invention are 5.2-42 parts of concentrated muskmelon powder, 10-25 parts of zinc-rich yeast powder, 0-10 parts of acerola cherry powder, 0-10 parts of sea buckthorn fruit powder, 0-5 parts of concentrated prunus wilsonii juice powder, 0-5 parts of liquorice, 0-5 parts of lycopene and 30-66 parts of auxiliary materials;

the adjuvants are more than one of isomalt, sorbitol, microcrystalline cellulose, silicon dioxide, and magnesium stearate.

In the concentrated muskmelon powder, 5-30 parts of grape seed extract, 0.1-6 parts of concentrated muskmelon powder and 0.1-6 parts of vitamin C are contained.

During processing, the components are mixed and stirred uniformly, and tabletting is directly carried out, wherein the weight of each tablet is 300-800 mg, so that a semi-finished product is obtained. And (5) filling the semi-finished product into a PET bottle, and sealing and storing to obtain a final finished product. The final product can be directly administered orally.

The invention has the beneficial effects that:

the invention adopts a formula integrating full effects, has various effects of whitening, resisting wrinkles and the like, and can promote the synthesis of endogenous collagen and skin lightening.

The grape seed extract contains abundant polyphenol and flavone components, has tyrosinase activity inhibiting effect, can block melanin formation in skin, and inhibit collagen hydrolase activity in vivo, thereby reducing collagen loss and inhibiting formation of fine wrinkles.

The concentrated melon powder contains superoxide dismutase (SOD), is helpful for removing free radicals in skin and purifying melanin, and can improve skin whiteness, and after being compounded with grape seed extract, the concentrated melon powder can also improve the crosslinking degree of collagen fiber, thereby improving skin elasticity. Therefore, the composition of the grape seed extract and the melon concentrated powder can play a synergistic role, on one hand, the brightness of the skin is improved, on the other hand, the elasticity of the skin is improved, and fine wrinkles are reduced.

The vitamin C can promote the synthesis of collagen, the formed collagen cannot be separated from a core substance hydroxyproline, and the grape seed extract can promote human fibroblasts to synthesize hydroxyproline, so that the collagen synthesis efficiency of the vitamin C is improved. Therefore, the compounding of the vitamin C and the grape seed extract can strengthen the synthesis of collagen fiber, and is superior to the single effect of the vitamin C.

The specific implementation mode is as follows:

example 1

13.4kg of Shikeaishi muskmelon concentrated powder (containing 10kg of grape seed extract, 1.7kg of muskmelon concentrated powder and 1.7kg of vitamin C), 10kg of zinc-rich yeast powder, 1kg of acerola powder, 1kg of sea buckthorn fruit powder, 1kg of wild cherry concentrated juice powder, 1kg of liquorice, 1kg of lycopene, 15kg of sorbitol, 16.3kg of microcrystalline cellulose and 0.3kg of magnesium stearate are mixed and stirred uniformly, and directly tabletted, wherein the weight of each tablet is 400mg, so that a semi-finished product is obtained. And (5) filling the semi-finished product into a PET bottle, and sealing and storing to obtain a final finished product.

Example 2 human fibroblast in vitro culture experiment

All test solutions were prepared in the presence of S9 (an enzyme-containing liver extract) and S9 was prepared from rat liver by homogenizing, low temperature centrifuging and collecting supernatant, and the protein concentration was 20mg/ml as determined by Coomassie Brilliant blue method, and the solution had multiple activating substrates and could simulate liver metabolism. The oral tablet prepared in example 1 was formulated with the S9 solution to 550. mu.g/mL for use as a efficacy group. And preparing 100 mu M vitamin C solution as VC (with the same VC content as the functional group) for later use.

The human fibroblast culture medium in a standard state is taken and added with a control group (S9 solution), a VC group and an efficacy group solution respectively for culture. The amount of type I collagen matrix (ECM) expression was measured by fluorescence imaging.

Compared with the collagen matrix expression quantity before culture, the collagen matrix expression quantity of the control fibroblast is increased by 39 ng/mu g, the collagen matrix expression quantity of the VC group is increased by 164 ng/mu g, the collagen expression quantity of the efficacy group is increased by 219 ng/mu g, the collagen expression quantity of the efficacy group is increased by 462 percent relative to the control group, and the collagen expression quantity of the efficacy group is increased by 34 percent relative to the VC group.

Example 3 human testing

20 women of 40-70 years old were selected, and the face complexion, fine wrinkles, mottle, dark circles and the like were recorded, and 1 tablet of the oral tablet prepared in example 1 was taken daily for 8 weeks.

The skin improvement of the subjects was observed after 8 weeks, wherein the skin brightness was increased by an average of 25.9%, the age spots were reduced by 19.2%, the dark circles were reduced by 19.2%, and the skin wrinkles were reduced by 11.7%. The composition has skin whitening, wrinkle removing and speckle reducing effects.

Claims

1. The composition is characterized by comprising, by weight, 5.2-42 parts of concentrated melon powder, 10-25 parts of zinc-rich yeast powder, 0-10 parts of acerola cherry powder, 0-10 parts of sea buckthorn fruit powder, 0-5 parts of concentrated wild cherry juice powder, 0-5 parts of liquorice, 0-5 parts of lycopene and 30-66 parts of auxiliary materials;

2. The composition for skin whitening and wrinkle removal as claimed in claim 1, wherein the concentrated powder of melon comprises 5-30 parts of grape seed extract, 0.1-6 parts of concentrated powder of melon, and 0.1-6 parts of vitamin C.