CN113504088A - Low-temperature preparation device for biochemical detection sample - Google Patents
Low-temperature preparation device for biochemical detection sample Download PDFInfo
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- CN113504088A CN113504088A CN202110771550.3A CN202110771550A CN113504088A CN 113504088 A CN113504088 A CN 113504088A CN 202110771550 A CN202110771550 A CN 202110771550A CN 113504088 A CN113504088 A CN 113504088A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/2813—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on
- G01N2001/2846—Cytocentrifuge method
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Abstract
The utility model provides a low temperature preparation facilities of biochemical detection sample, the device is including the casing, is provided with in the casing and divides the casing into the baffle of upper chamber and lower chamber, installs the centrifugal unit that is used for centrifugal blood sample in the upper chamber, is used for weighing the weighing unit of ultrapure water and blood sample ratio, is used for adding the storage unit of ultrapure water in the weighing unit, is used for storing the carousel unit of finished product blood sample, still includes the sample transmission unit that is arranged in with optional sample to carousel unit, weighing unit of blood sample in the centrifugal unit. The invention can automatically extract the plasma sample and the erythrocyte sample from the blood, has simple structure, reduces the labor intensity of workers, avoids the hands of the workers from being frostbitten in the low-temperature environment, and avoids the frequent change of the blood sample between the extraction and centrifugation processes in the low-temperature environment and the room-temperature environment to influence the sample quality.
Description
Technical Field
The invention relates to the field of medical instruments, in particular to a low-temperature preparation device for a biochemical detection sample.
Background
Biochemical full-set examination refers to physical examination of a person by biological or chemical means. The biochemical complete set of examination content comprises: liver function (total protein, albumin, globulin, white to globulin ratio, total bilirubin, direct, indirect bilirubin, transaminase); blood lipids (total cholesterol, triglycerides, high and low density lipoproteins, apolipoproteins); fasting blood glucose; renal function (creatinine, urea nitrogen); uric acid; a lactate dehydrogenase; creatine creatinase, and the like.
Plasma and erythrocyte samples are commonly used in various medical examinations, medical workers need to take fresh blood and add the fresh blood into a test tube containing anticoagulant, the blood is reversely mixed, the blood is centrifuged for 10min at 700-1000 Xg in a low-temperature environment, the yellowish transparent liquid at the upper layer is sampled to be plasma, and middle white interference layers (white blood cells and platelets) cannot be sucked. The plasma is placed on ice to be tested, if the plasma can not be tested on the same day, the plasma is stored at minus 80 ℃ and can be stored for one month.
And (3) after the middle white interference layer is removed, precipitating the lower layer of red blood cells, mixing with ultrapure water with 4 times of volume and the temperature of 2-8 ℃, centrifuging for 15min at 10000 Xg in a low-temperature environment, and sampling supernatant to obtain the red blood cell lysate.
Because the steps are complicated and hemolysis can be avoided to a certain extent in a low-temperature environment, the preparation is often carried out in a low-temperature environment, the operation is inconvenient, and a device convenient for preparing plasma and erythrocyte samples is urgently needed.
Disclosure of Invention
The invention aims to provide a low-temperature preparation device for a biochemical detection sample.
The invention aims to realize the technical scheme, which comprises a shell, wherein a clapboard for dividing the shell into an upper chamber and a lower chamber is arranged in the shell, a centrifugal unit for centrifuging a blood sample, a weighing unit for weighing the ratio of ultrapure water to the blood sample, a storage unit for adding ultrapure water into the weighing unit, a turntable unit for storing a finished blood sample, and a sampling transmission unit for selectively sampling the blood sample in the centrifugal unit into the turntable unit and the weighing unit are arranged in the upper chamber;
the inlet end of the centrifugal unit is communicated with the outside, the sampling end of the sampling transmission unit is movably communicated with the outlet end of the centrifugal unit, the inlet end of the turntable unit and the weighing end of the weighing unit respectively, the outlet end of the turntable unit is communicated with the outside, and the outlet end of the storage unit is communicated with the weighing end of the weighing unit.
Preferably, the sampling and transmitting unit comprises a first electric telescopic rod, the first electric telescopic rod is installed on the top surface of the partition plate, the telescopic direction of the first electric telescopic rod is perpendicular to the partition plate, the telescopic end of the first electric telescopic rod is fixedly connected with a first motor, the output shaft of the first motor is perpendicular to the partition plate and fixedly connected with a first disc, four connecting plates are uniformly and fixedly connected to the outer circumferential wall of the first disc in a radial manner around the circle center, the bottom surfaces of the three connecting plates are fixedly connected with one end of a first sleeve, the other end of the first sleeve points to the partition plate and is perpendicular to the partition plate, a first rotating shaft is rotatably installed in the first sleeve, a second motor is installed on the top surface of each connecting plate, and the output shaft of the second motor rotatably penetrates through the connecting plates and is fixedly connected with the first rotating shaft;
the sampling transmission unit also comprises a first sampling cup, one end of the first sleeve, which points to the partition plate, is fixedly connected with the circle center position of the bottom surface at the inner side of the first sampling cup, a second sampling cup is sleeved outside the first sampling cup, one end of the first rotating shaft, which points to the partition plate, passes through the bottom surface of the first sampling cup and is fixedly connected with the circle center position of the bottom surface at the inner side of the second sampling cup, and a plurality of sampling holes which correspond to one another one to one are formed in the bottom surfaces of the first sampling cup and the second sampling cup;
one of the connecting plates is fixedly connected with an electric control gripper capable of gripping a sample.
Preferably, the centrifugal unit comprises a cylinder base with an opening on the top surface, the cylinder base is rotatably arranged on the partition plate and is positioned below the motion track of the sampling transmission unit, a third motor is arranged in the lower chamber, and an output shaft of the third motor rotatably penetrates through the partition plate to be fixedly connected with the circle center of the bottom surface of the cylinder base;
the inner wall of the circumference of the cylinder base is provided with a plurality of sliding grooves parallel to the axial lead of the cylinder base, and the centrifugal tube is slidably arranged in the sliding grooves of the cylinder base through sliding blocks on the outer wall of the circumference.
As preferred, weigh the unit including first mount pad, first mount pad rigid coupling is at the baffle top surface, but the middle part luffing motion of first bull stick articulates on first mount pad, but the one end rigid coupling that sample transmission unit was kept away from to first bull stick has top surface open-ended ultrapure water to connect and gets a section of thick bamboo, ultrapure water connects and gets a section of thick bamboo on the circumference outer wall of a section of thick bamboo and has first outlet pipe, the rigid coupling has first solenoid valve on the first outlet pipe, first bull stick other end rigid coupling has top surface open-ended centrifuging tube to place a section of thick bamboo, and the centrifuging tube is placed a motion orbit below that is located sample transmission unit, the centrifuging tube is placed a section of thick bamboo and is connect for ultrapure water with the distance of first mount pad and get the quadruple of the distance of a section of thick bamboo and first mount pad, still install trigger switch on the baffle, and trigger switch is located ultrapure water and connects and gets a section of thick bamboo below.
Preferably, the storage unit is including the ultrapure water bucket, the rigid coupling has the first platform parallel with the baffle on the last chamber lateral wall, the ultrapure water bucket is rotatable to be installed at first platform top surface, the rigid coupling has the second outlet pipe on the circumference outer wall of ultrapure water bucket, and the second outlet pipe can be located the centrifuging tube respectively and place a section of thick bamboo and ultrapure water and connect and get a section of thick bamboo top, the rigid coupling has the second solenoid valve on the second outlet pipe, the fourth motor is installed to first platform bottom surface, the output shaft of fourth motor passes first platform and ultrapure water bucket bottom surface centre of a circle position rigid coupling.
Preferably, the turntable unit comprises a turntable, the turntable is rotatably mounted on the partition plate, a plurality of grooves for holding blood sample test tubes are formed in the top surface of the turntable, the grooves can be located below the movement track of the sampling transmission unit, a fifth motor is mounted in the lower cavity, and an output shaft of the fifth motor rotatably penetrates through the partition plate to be fixedly connected with the circle center of the bottom surface of the turntable.
Preferably, a refrigerating device is installed in the upper chamber, a first hinge door capable of communicating the centrifugal unit with the outside and a second hinge door capable of communicating the turntable unit with the outside are arranged on the side wall of the upper chamber.
Due to the adoption of the technical scheme, the invention has the following advantages:
1. the invention can automatically extract the plasma sample and the erythrocyte sample from the blood, has simple structure, reduces the labor intensity of workers, can complete the whole process in a low-temperature environment, avoids the hand of the workers who are manually operated from being frostbitten, and also avoids the influence on the sample quality caused by frequent change of the blood sample between the storage and the centrifugation process in the low-temperature environment and the room-temperature environment during the manual operation.
2. The sampling transmission unit is simple in structure, the sampling holes are opened and closed through rotation of the first sampling cup and the second sampling cup to finish sampling, sampling at any depth is realized through the first electric telescopic rod, and the accuracy of sampling depth is guaranteed.
3. The weighing unit is placed at the one end of the weighing unit through a lever structure, water is added to the other end until the two ends are balanced, and through adjusting the relative length of the force arms on the two sides, the added ultrapure water can be ensured to be a plurality of multiples of the weight of the sample in the centrifugal tube at this time, and the weight of the sample in the centrifugal tube at each time does not need to be frequently measured.
Additional advantages, objects, and features of the invention will be set forth in part in the description which follows and in part will become apparent to those having ordinary skill in the art upon examination of the following or may be learned from practice of the invention. The objectives and other advantages of the invention will be realized and attained by the structure particularly pointed out in the written description and claims hereof.
Drawings
The drawings of the present invention are described below.
FIG. 1 is an internal schematic view of the present invention.
Fig. 2 is an exploded view of a sample transmission unit of the present invention.
FIG. 3 is a schematic diagram of the centrifugation of the present invention.
FIG. 4 is a weighing schematic of the present invention.
FIG. 5 is a schematic diagram of a memory cell according to the present invention.
Fig. 6 is a schematic view of a turntable unit of the present invention.
Fig. 7 is a schematic view of the refrigeration apparatus of the present invention.
Fig. 8 is an external schematic view of the present invention.
In the figure: 1. a housing; 2. an upper chamber; 3. a lower chamber; 4. a partition plate; 5. a first electric telescopic rod; 6. a first motor; 7. a first disc; 8. a connecting plate; 9. a first sleeve; 10. a first rotating shaft; 11. a second motor; 12. a first sampling cup; 13. a second sampling cup; 14. a sampling hole; 15. electrically controlled clamping hands; 16. a cylindrical base; 17. a third motor; 18. a chute; 19. a first mounting seat; 20. a first rotating lever; 21. an ultrapure water receiving cylinder; 22. a first water outlet pipe; 23. a first solenoid valve; 24. a centrifuge tube placement barrel; 25. an ultrapure water storage barrel; 26. a first platform; 27. a second water outlet pipe; 28. a second solenoid valve; 29. a fourth motor; 30. a turntable; 31. a blood sample tube; 32. a groove; 33. a fifth motor; 34. a refrigeration device; 35. a first hinge door; 36. a second hinge door; 37. a trigger switch; 38. centrifuging the tube; 39. a slide block.
Detailed Description
The invention is further illustrated by the following figures and examples.
In the description of the embodiments of the present invention, it should be noted that the terms "center", "longitudinal", "lateral", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", and the like indicate orientations or positional relationships based on those shown in the drawings, and are only for convenience in describing the embodiments of the present invention and simplifying the description, but do not indicate or imply that the referred devices or elements must have a specific orientation, be constructed in a specific orientation, and be operated, and thus, should not be construed as limiting the embodiments of the present invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance. In the description of the embodiments of the present invention, it should be noted that, unless explicitly stated or limited otherwise, the terms "connected" and "connected" are to be interpreted broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; may be directly connected or indirectly connected through an intermediate. Specific meanings of the above terms in the embodiments of the present invention can be understood in specific cases by those of ordinary skill in the art.
As shown in fig. 1, a low-temperature preparation device for biochemical detection samples comprises a housing 1, a partition plate 4 for dividing the housing 1 into an upper chamber 2 and a lower chamber 3 is arranged in the housing 1, a centrifugal unit for centrifuging a blood sample, a weighing unit for weighing a ratio of ultrapure water to the blood sample, a storage unit for adding ultrapure water into the weighing unit, a turntable unit for storing a finished blood sample, and a sampling transmission unit for selectively sampling the blood sample in the centrifugal unit into the turntable unit and the weighing unit;
the inlet end of the centrifugal unit is communicated with the outside, the sampling end of the sampling transmission unit is movably communicated with the outlet end of the centrifugal unit, the inlet end of the turntable unit and the weighing end of the weighing unit respectively, the outlet end of the turntable unit is communicated with the outside, and the outlet end of the storage unit is communicated with the weighing end of the weighing unit.
In the embodiment, fresh blood is put into a centrifuge tube of a centrifuge unit for centrifugation, after primary centrifugation is completed, supernatant in the centrifuge tube is plasma, a middle white layer is white blood cells and platelets, a lower layer is red blood cell sediment, and a sampling transmission unit firstly samples upper plasma into a blood sample test tube positioned below a motion track of the sampling transmission unit in a turntable unit for storage;
the sampling transmission unit returns to the centrifuge tube, the turntable unit rotates to switch a new blood sample test tube, and the sampling transmission unit samples the white blood cells and the platelets in the middle layer into a new blood sample test tube of the turntable unit for storage;
the residual part in the centrifuge tube is lower layer erythrocyte sediment, the sampling transmission unit grabs the centrifuge tube to the weighing unit, after weighing, the storage unit adds 4 times of ultrapure water to the centrifuge tube to mix, the sampling transmission unit grabs the centrifuge tube and inserts the centrifuge tube back into the centrifuge unit to centrifuge, after the centrifugation is finished, the supernatant in the centrifuge tube is erythrocyte lysate, the turntable unit switches a new blood sample test tube again, the sampling transmission unit samples the erythrocyte lysate to a new blood sample test tube of the turntable unit to store; finally, the worker opens the device and takes out three tubes of samples;
the device can automatically complete the extraction of the plasma and the red blood cell samples, and reduces the labor intensity of workers.
As shown in fig. 2, the sampling transmission unit includes a first electric telescopic rod 5, the first electric telescopic rod 5 is installed on the top surface of a partition plate 4, and the telescopic direction of the first electric telescopic rod is perpendicular to the partition plate 4, the telescopic end of the first electric telescopic rod 5 is fixedly connected with a first motor 6, the output shaft of the first motor 6 is perpendicular to the partition plate 4 and fixedly connected with a first disc 7, four connecting plates 8 are uniformly and radially fixedly connected on the circumferential outer wall of the first disc 7 around the center of a circle, wherein the bottom surfaces of the three connecting plates 8 are fixedly connected with one end of a first sleeve 9, the other end of the first sleeve 9 points to the partition plate 4 and is perpendicular to the partition plate 4, a first rotating shaft 10 is rotatably installed in the first sleeve 9, a second motor 11 is installed on the top surface of each connecting plate 8, and the output shaft of the second motor 11 rotatably passes through the connecting plate 8 and is fixedly connected with the first rotating shaft 10;
the sampling transmission unit further comprises a first sampling cup 12, one end of the first sleeve 9, which points to the partition plate 4, is fixedly connected with the circle center position of the bottom surface of the inner side of the first sampling cup 12, a second sampling cup 13 is sleeved outside the first sampling cup 12, one end of the first rotating shaft 10, which points to the partition plate 4, passes through the bottom surface of the first sampling cup 12 and is fixedly connected with the circle center position of the bottom surface of the inner side of the second sampling cup 13, and a plurality of sampling holes 14 which correspond to one another are respectively formed in the bottom surfaces of the first sampling cup 12 and the second sampling cup 13;
one of the connecting plates 8 is fixedly connected with an electric control gripper 15 which can grab a sample on the bottom surface.
In the embodiment, the first electric telescopic rod drives the sampling transmission unit to complete lifting action, the first motor drives the sampling transmission unit to complete rotating action, when sampling is needed, the first motor drives the first disc, the first disc drives the connecting plate and the first sampling cup and the second sampling cup below the connecting plate to move, the sampling holes are aligned when the first sampling cup and the second sampling cup are in an initial state, the first sampling cup and the second sampling cup move to the upper part of the centrifuge tube, the first electric telescopic rod descends, the first sampling cup and the second sampling cup slowly descend into the centrifuge tube, samples in different layers can be sampled in the centrifuge tube, the samples pass through the sampling holes and enter the first sampling cup, the second motor controls the second sampling cup to rotate, the sampling holes are staggered to form a closed space after rotation, the samples in the first sampling cup are left in the first sampling cup, the first electric telescopic rod drives the sampling cup filled with the samples to ascend and leave the centrifuge tube, the first motor rotates, the sampling cup with the sample rotates to the rotary table unit, the first electric telescopic rod descends again, the sampling cup with the sample descends to a blood sample test tube of the rotary table unit, the second motor rotates, the sampling holes of the first sampling cup and the second sampling cup are aligned, the blood sample flows into the blood sample test tube to be stored, three groups of sampling cups are used for three different samples, and mutual pollution can be avoided;
the automatically controlled tong can accomplish and go up and down, snatch and rotate, both be used for snatching the centrifuge tube to weighing the unit, snatch back centrifugal unit from weighing the unit with the centrifuge tube, still be used for screwing up the tube cap when the centrifuging tube centrifugation, unscrew the tube cap when adding ultrapure water on weighing the unit.
As shown in fig. 3, the centrifugal unit includes a cylindrical base 16 with an opening on the top surface, the cylindrical base 16 is rotatably installed on the partition plate 4 and located below the movement track of the sampling and transmitting unit, a third motor 17 is installed in the lower chamber 3, and an output shaft of the third motor 17 rotatably penetrates through the partition plate 4 to be fixedly connected with the center of the bottom surface of the cylindrical base 16;
the inner wall of the circumference of the cylinder base 16 is provided with a plurality of sliding grooves 18 parallel to the axial lead of the cylinder base 16, and the centrifugal tube 38 is slidably arranged in the sliding grooves 18 of the cylinder base 16 through sliding blocks 39 on the outer wall of the circumference.
In this embodiment, the centrifuging tube inserts in the drum base, follows the drum base and rotates the centrifugation together, and the centrifuging tube can be guaranteed with the drum base rotation in step to slider and spout cooperation, and prevents the centrifuging tube rotation when automatically controlled tong twists the tube cap.
As shown in FIG. 4, the weighing unit includes a first mounting seat 19, the first mounting seat 19 is fixedly connected to the top surface of the partition board 4, the middle portion of a first rotating rod 20 is hinged to the first mounting seat 19 in a vertically swinging manner, one end of the first rotating rod 20, which is far away from the sampling transmission unit, is fixedly connected to an ultrapure water receiving cylinder 21 with an open top surface, a first water outlet pipe 22 is fixedly connected to the circumferential outer wall of the ultrapure water receiving cylinder 21, a first electromagnetic valve 23 is fixedly connected to the first water outlet pipe 22, the other end of the first rotating rod 20 is fixedly connected to a centrifugal tube placing cylinder 24 with an open top surface, and the centrifugal tube placing cylinder 24 is positioned below the motion track of the sampling transmission unit, the distance between the centrifugal tube placing cylinder 24 and the first mounting seat 19 is four times the distance between the ultrapure water receiving cylinder 21 and the first mounting seat 19, the partition board 4 is also provided with a trigger switch 37, and the trigger switch 37 is positioned below the ultrapure water receiving cylinder 21.
In the embodiment, the arm length of force at one end of the centrifugal tube placing cylinder is four times that of the arm length at one end of the ultrapure water receiving cylinder, therefore, the initial state of the first rotating rod inclines towards one end of the centrifugal tube placing cylinder, after the electric control gripper inserts the centrifugal tube into the centrifugal tube placing cylinder, the storage unit is controlled to inject ultrapure water into the ultrapure water receiving cylinder, because of the arm length, the ultrapure water receiving cylinder has more and more water and heavier weight, until the weight of the ultrapure water in the ultrapure water receiving cylinder is four times that of the sample in the centrifugal tube placing cylinder, the first rotating rod is changed into a balanced state, the bottom surface of the ultrapure water receiving cylinder touches the trigger switch, the trigger switch is started, the water outlet of the storage unit rotates, the ultrapure water is injected into the centrifugal tube inserted into the centrifugal tube placing cylinder at the moment, and the ultrapure water injection into the centrifugal tube by the storage unit is stopped when the flow rate of the ultrapure water injected into the ultrapure water receiving cylinder is consistent with the flow rate, through lever balanced structure, guaranteed that the injection volume of ultrapure water must be four times of the sample in the centrifuging tube, then, automatically controlled tong snatchs the centrifuging tube and gets back to centrifugal unit and carry out the secondary centrifugation, and the ultrapure water that ultrapure water connects and gets in the section of thick bamboo then is discharged by first outlet pipe and first solenoid valve.
As shown in fig. 5, the storage unit includes an ultrapure water storage barrel 25, a first platform 26 parallel to the partition plate 4 is fixedly connected to the side wall of the upper chamber 2, the ultrapure water storage barrel 25 is rotatably mounted on the first platform top surface 26, a second water outlet pipe 27 is fixedly connected to the outer wall of the circumference of the ultrapure water storage barrel 25, the second water outlet pipe 27 can be respectively located above the centrifugal tube placing barrel 24 and the ultrapure water receiving barrel 21, a second electromagnetic valve 28 is fixedly connected to the second water outlet pipe 27, a fourth motor 29 is mounted on the bottom surface of the first platform 26, and an output shaft of the fourth motor 29 passes through the first platform 26 and is fixedly connected to the center of the circle of the bottom surface of the ultrapure water storage barrel 25.
In this embodiment, the fourth motor can control the ultrapure water storage barrel to rotate, and the second water outlet pipe can respectively inject ultrapure water into the centrifugal tube placing barrel and the ultrapure water receiving barrel in a rotating state.
As shown in fig. 6, the turntable unit includes a turntable 30, the turntable 30 is rotatably mounted on the partition plate 4, the top surface of the turntable 30 is provided with a plurality of grooves 32 for placing blood sample test tubes 31, the grooves 32 can be located below the movement track of the sampling transmission unit, a fifth motor 33 is mounted in the lower chamber 3, and an output shaft of the fifth motor 33 rotatably penetrates through the partition plate 4 to be fixedly connected with the center of the bottom surface of the turntable 30.
In this embodiment, the fifth motor controls the rotation of the turntable, and when the sampling and transmitting unit transmits a certain sample to the blood sample test tube, the fifth motor is started to drive the turntable to switch a new blood sample test tube to the position below the movement track of the sampling and transmitting unit.
As shown in fig. 7 to 8, a refrigerating device 34 is installed in the upper chamber 2, and a first hinge door 35 and a second hinge door 36 are opened on a side wall of the upper chamber 2, wherein the first hinge door can communicate the centrifugal unit with the outside, and the second hinge door can communicate the turntable unit with the outside.
In the embodiment, the whole sample preparation process is carried out at a low temperature, the temperature in the shell can be adjusted by the refrigerating device, the low temperature can avoid hemolysis to a certain extent, and the sample can be stored in a short time;
the first hinge door is opened to place fresh blood into the centrifugal unit, and the second hinge door is opened to take out finished samples on the rotary disc unit one by one.
Finally, it should be noted that: the above embodiments are only for illustrating the technical solutions of the present invention and not for limiting the same, and although the present invention is described in detail with reference to the above embodiments, those of ordinary skill in the art should understand that: modifications and equivalents may be made to the embodiments of the invention without departing from the spirit and scope of the invention, which is to be covered by the claims.
Claims (7)
1. The low-temperature preparation device for the biochemical detection sample is characterized by comprising a shell (1), wherein a partition plate (4) for dividing the shell (1) into an upper chamber (2) and a lower chamber (3) is arranged in the shell (1), a centrifugal unit for centrifuging a blood sample, a weighing unit for weighing the ratio of ultrapure water to the blood sample, a storage unit for adding ultrapure water into the weighing unit, a turntable unit for storing a finished blood sample and a sampling transmission unit for selectively sampling the blood sample in the centrifugal unit into the turntable unit and the weighing unit are arranged in the upper chamber (2);
the inlet end of the centrifugal unit is communicated with the outside, the sampling end of the sampling transmission unit is movably communicated with the outlet end of the centrifugal unit, the inlet end of the turntable unit and the weighing end of the weighing unit respectively, the outlet end of the turntable unit is communicated with the outside, and the outlet end of the storage unit is communicated with the weighing end of the weighing unit.
2. The low-temperature preparation device of biochemical detection samples according to claim 1, wherein the sampling transmission unit comprises a first electric telescopic rod (5), the first electric telescopic rod (5) is installed on the top surface of the partition plate (4) and the telescopic direction is perpendicular to the partition plate (4), the telescopic end of the first electric telescopic rod (5) is fixedly connected with a first motor (6), the output shaft of the first motor (6) is perpendicular to the partition plate (4) and is fixedly connected with a first disk (7), four connecting plates (8) are uniformly and fixedly connected on the circumferential outer wall of the first disk (7) in a radial shape around the center of a circle, wherein the bottom surfaces of the three connecting plates (8) are fixedly connected with one end of a first sleeve (9), the other end of the first sleeve (9) points to the partition plate (4) and is perpendicular to the partition plate (4), and a first rotating shaft (10) is rotatably installed in the first sleeve (9), a second motor (11) is mounted on the top surface of each connecting plate (8), and an output shaft of each second motor (11) can rotatably penetrate through the connecting plates (8) to be fixedly connected with the first rotating shaft (10);
the sampling transmission unit further comprises a first sampling cup (12), one end of a first sleeve (9) pointing to the partition plate (4) is fixedly connected with the circle center of the inner bottom surface of the first sampling cup (12), a second sampling cup (13) is sleeved outside the first sampling cup (12), one end of a first rotating shaft (10) pointing to the partition plate (4) penetrates through the bottom surface of the first sampling cup (12) and is fixedly connected with the circle center of the inner bottom surface of the second sampling cup (13), and a plurality of sampling holes (14) corresponding to one another are formed in the bottom surfaces of the first sampling cup (12) and the second sampling cup (13);
one of the connecting plates (8) is fixedly connected with an electric control gripper (15) capable of grabbing a sample on the bottom surface.
3. The low-temperature preparation device for biochemical detection samples according to claim 1, wherein the centrifugal unit comprises a cylinder base (16) with an open top surface, the cylinder base (16) is rotatably mounted on the partition plate (4) and located below the motion track of the sampling and transmission unit, a third motor (17) is mounted in the lower chamber (3), and an output shaft of the third motor (17) rotatably penetrates through the partition plate (4) to be fixedly connected with the center of the bottom surface of the cylinder base (16);
the inner wall of the circumference of the cylinder base (16) is provided with a plurality of sliding grooves (18) which are parallel to the axial lead of the cylinder base (16), and the centrifugal tube (38) is slidably arranged in the sliding grooves (18) of the cylinder base (16) through sliding blocks (39) on the outer wall of the circumference.
4. The low-temperature preparation device for biochemical detection samples according to claim 1, wherein the weighing unit comprises a first mounting seat (19), the first mounting seat (19) is fixedly connected to the top surface of the partition plate (4), the middle part of the first rotating rod (20) is hinged to the first mounting seat (19) in a way of swinging up and down, one end of the first rotating rod (20) far away from the sampling transmission unit is fixedly connected with an ultrapure water receiving and taking barrel (21) with an open top surface, the circumferential outer wall of the ultrapure water receiving and taking barrel (21) is fixedly connected with a first water outlet pipe (22), the first water outlet pipe (22) is fixedly connected with a first electromagnetic valve (23), the other end of the first rotating rod (20) is fixedly connected with a centrifugal tube placing barrel (24) with an open top surface, the centrifugal tube placing barrel (24) is located below the motion track of the sampling transmission unit, the distance between the centrifugal tube placing barrel (24) and the first mounting seat (19) is four times the distance between the ultrapure water receiving barrel (21) and the first mounting seat (19), the partition board (4) is also provided with a trigger switch (37), and the trigger switch (37) is positioned below the ultrapure water receiving cylinder (21).
5. The low-temperature preparation device of biochemical detection sample according to claim 1, wherein the storage unit comprises an ultrapure water storage barrel (25), a first platform (26) parallel to the partition plate (4) is fixedly connected to the side wall of the upper chamber (2), the ultrapure water storage barrel (25) is rotatably mounted on the first platform top surface (26), a second water outlet pipe (27) is fixedly connected to the outer wall of the circumference of the ultrapure water storage barrel (25), the second water outlet pipe (27) is respectively located above the centrifugal tube placing barrel (24) and the ultrapure water receiving barrel (21), a second electromagnetic valve (28) is fixedly connected to the second water outlet pipe (27), a fourth motor (29) is mounted on the bottom surface of the first platform (26), and an output shaft of the fourth motor (29) passes through the first platform (26) and is fixedly connected to the center of the circle of the bottom surface of the ultrapure water storage barrel (25).
6. The low-temperature preparation device for biochemical detection samples according to claim 1, wherein the turntable unit comprises a turntable (30), the turntable (30) is rotatably mounted on the partition plate (4), the top surface of the turntable (30) is provided with a plurality of grooves (32) for placing blood sample test tubes (31), the grooves (32) can be located below the movement track of the sampling transmission unit, a fifth motor (33) is mounted in the lower chamber (3), and an output shaft of the fifth motor (33) rotatably penetrates through the partition plate (4) to be fixedly connected with the center of the circle of the bottom surface of the turntable (30).
7. The low-temperature preparation device for biochemical detection samples according to claim 1, wherein a refrigeration device (34) is installed in the upper chamber (2), a first hinge door (35) for communicating the centrifugal unit with the outside and a second hinge door (36) for communicating the turntable unit with the outside are opened on the side wall of the upper chamber (2).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110771550.3A CN113504088A (en) | 2021-07-08 | 2021-07-08 | Low-temperature preparation device for biochemical detection sample |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110771550.3A CN113504088A (en) | 2021-07-08 | 2021-07-08 | Low-temperature preparation device for biochemical detection sample |
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| CN113504088A true CN113504088A (en) | 2021-10-15 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202110771550.3A Withdrawn CN113504088A (en) | 2021-07-08 | 2021-07-08 | Low-temperature preparation device for biochemical detection sample |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114132883A (en) * | 2021-11-29 | 2022-03-04 | 吴月红 | Serum protein inhibitor injection loading equipment capable of reducing aerosol pollution |
| CN115339768A (en) * | 2022-08-30 | 2022-11-15 | 重庆医药高等专科学校 | Storage device of medical science inspection sample |
-
2021
- 2021-07-08 CN CN202110771550.3A patent/CN113504088A/en not_active Withdrawn
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114132883A (en) * | 2021-11-29 | 2022-03-04 | 吴月红 | Serum protein inhibitor injection loading equipment capable of reducing aerosol pollution |
| CN114132883B (en) * | 2021-11-29 | 2023-12-22 | 义乌市奥飞创意设计有限公司 | Serum protein inhibitor injection loading device capable of reducing aerosol pollution |
| CN115339768A (en) * | 2022-08-30 | 2022-11-15 | 重庆医药高等专科学校 | Storage device of medical science inspection sample |
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Application publication date: 20211015 |