CN113488192A - New crown vaccine information tracing method and system based on block chain - Google Patents

New crown vaccine information tracing method and system based on block chain Download PDF

Info

Publication number
CN113488192A
CN113488192A CN202110845725.0A CN202110845725A CN113488192A CN 113488192 A CN113488192 A CN 113488192A CN 202110845725 A CN202110845725 A CN 202110845725A CN 113488192 A CN113488192 A CN 113488192A
Authority
CN
China
Prior art keywords
information
vaccine
blockchain
new
block chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202110845725.0A
Other languages
Chinese (zh)
Inventor
乜鹏
周新星
曾玉冰
郑惠麟
王冲
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nankai University
Original Assignee
Nankai University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nankai University filed Critical Nankai University
Priority to CN202110845725.0A priority Critical patent/CN113488192A/en
Publication of CN113488192A publication Critical patent/CN113488192A/en
Pending legal-status Critical Current

Links

Images

Classifications

    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/80ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for detecting, monitoring or modelling epidemics or pandemics, e.g. flu
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06FELECTRIC DIGITAL DATA PROCESSING
    • G06F16/00Information retrieval; Database structures therefor; File system structures therefor
    • G06F16/20Information retrieval; Database structures therefor; File system structures therefor of structured data, e.g. relational data
    • G06F16/24Querying
    • G06F16/245Query processing
    • G06F16/2458Special types of queries, e.g. statistical queries, fuzzy queries or distributed queries
    • G06F16/2471Distributed queries
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06FELECTRIC DIGITAL DATA PROCESSING
    • G06F16/00Information retrieval; Database structures therefor; File system structures therefor
    • G06F16/20Information retrieval; Database structures therefor; File system structures therefor of structured data, e.g. relational data
    • G06F16/24Querying
    • G06F16/248Presentation of query results
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06FELECTRIC DIGITAL DATA PROCESSING
    • G06F16/00Information retrieval; Database structures therefor; File system structures therefor
    • G06F16/20Information retrieval; Database structures therefor; File system structures therefor of structured data, e.g. relational data
    • G06F16/27Replication, distribution or synchronisation of data between databases or within a distributed database system; Distributed database system architectures therefor
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06FELECTRIC DIGITAL DATA PROCESSING
    • G06F16/00Information retrieval; Database structures therefor; File system structures therefor
    • G06F16/20Information retrieval; Database structures therefor; File system structures therefor of structured data, e.g. relational data
    • G06F16/28Databases characterised by their database models, e.g. relational or object models
    • G06F16/284Relational databases
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06FELECTRIC DIGITAL DATA PROCESSING
    • G06F21/00Security arrangements for protecting computers, components thereof, programs or data against unauthorised activity
    • G06F21/60Protecting data
    • G06F21/602Providing cryptographic facilities or services
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06FELECTRIC DIGITAL DATA PROCESSING
    • G06F21/00Security arrangements for protecting computers, components thereof, programs or data against unauthorised activity
    • G06F21/60Protecting data
    • G06F21/64Protecting data integrity, e.g. using checksums, certificates or signatures
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06KGRAPHICAL DATA READING; PRESENTATION OF DATA; RECORD CARRIERS; HANDLING RECORD CARRIERS
    • G06K17/00Methods or arrangements for effecting co-operative working between equipments covered by two or more of main groups G06K1/00 - G06K15/00, e.g. automatic card files incorporating conveying and reading operations
    • G06K17/0022Methods or arrangements for effecting co-operative working between equipments covered by two or more of main groups G06K1/00 - G06K15/00, e.g. automatic card files incorporating conveying and reading operations arrangements or provisious for transferring data to distant stations, e.g. from a sensing device
    • G06K17/0025Methods or arrangements for effecting co-operative working between equipments covered by two or more of main groups G06K1/00 - G06K15/00, e.g. automatic card files incorporating conveying and reading operations arrangements or provisious for transferring data to distant stations, e.g. from a sensing device the arrangement consisting of a wireless interrogation device in combination with a device for optically marking the record carrier

Landscapes

  • Engineering & Computer Science (AREA)
  • Theoretical Computer Science (AREA)
  • Databases & Information Systems (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Data Mining & Analysis (AREA)
  • Health & Medical Sciences (AREA)
  • Computer Security & Cryptography (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Software Systems (AREA)
  • Medical Informatics (AREA)
  • Computer Hardware Design (AREA)
  • Bioethics (AREA)
  • Computational Linguistics (AREA)
  • Epidemiology (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Primary Health Care (AREA)
  • Fuzzy Systems (AREA)
  • Mathematical Physics (AREA)
  • Probability & Statistics with Applications (AREA)
  • Computer Networks & Wireless Communication (AREA)
  • Computing Systems (AREA)
  • Information Retrieval, Db Structures And Fs Structures Therefor (AREA)

Abstract

The invention belongs to the technical field of information, and particularly relates to a new crown vaccine information tracing method and system based on a block chain. The system comprises a data acquisition module: the system is used for acquiring production information, transportation information and injection information of the new corona vaccine; a data storage module: the data acquired by the data acquisition module is transmitted to the data storage module for storage; the query module: the data storage module is used for inquiring the information stored by the data storage module and displaying the inquiry result to the inquirer.

Description

New crown vaccine information tracing method and system based on block chain
Technical Field
The invention belongs to the technical field of information, and particularly relates to a new crown vaccine information tracing method and system based on a block chain.
Background
At present, new coronaviruses are still prevalent worldwide, and under the human fate community, injection of vaccines has become a necessary measure to combat new coronaviruses. Therefore, a management platform with safety regulations is needed to be provided for production, transportation and inoculation of the new corona vaccine, and a non-falsifiable certificate for inoculation of the new corona vaccine is provided for citizens.
The existing vaccine information traceability system stores vaccine production and circulation information in a database, belongs to a centralized storage management mode, and has low reliability and safety when an attacker invades the database system and medicine information covers the whole army. The current new crown vaccination voucher is generally paper edition, which can not well prevent the vaccination information from being randomly tampered.
Disclosure of Invention
Therefore, a new corona vaccine information tracing method and system based on a block chain are needed to be provided, so that the production, transportation and injection information of the new corona vaccine is well documented and is not easy to tamper. In order to achieve the purpose, the invention provides a block chain-based new crown vaccine information traceability method which is applied to a block chain-based new crown vaccine information traceability system.
The invention solves the problem that the production, transportation and inoculation information of the new corona vaccine is maliciously tampered; the problem that the new crown vaccination voucher is maliciously tampered is solved; the national confidence of the new coronary vaccine is improved; the problem that the injection information of the new coronary vaccine is not completely synchronized between provinces and cities is solved.
In order to achieve the purpose, the invention provides the following technical scheme:
a new crown vaccine information traceability system based on a block chain comprises,
a data acquisition module: the system is used for acquiring production information, transportation information and injection information of the new corona vaccine;
a data storage module: the data acquired by the data acquisition module is transmitted to the data storage module for storage;
the query module: the data storage module is used for inquiring the information stored by the data storage module and displaying the inquiry result to the inquirer.
According to the further optimization of the technical scheme, the data acquisition module comprises Internet of things equipment, a smart phone and a computer.
In a further optimization of the technical scheme, the data storage module comprises a relational database and a block chain.
According to the technical scheme, the block chain is further optimized by using an Ether house block chain technology, an Ether house alliance chain is established, and an account on the alliance chain is established for a querier.
According to the further optimization of the technical scheme, the query module generates the two-dimensional code so as to facilitate query.
A new crown vaccine information tracing method based on a block chain comprises the following steps,
s1, the vaccine manufacturer uploads the production information of the new corona vaccine to a block chain;
s2, the transportation company uploads the transportation information of the new crown vaccine to a block chain;
s3, the vaccination hospital encrypts the vaccination information of the new crown vaccine by using an encryption algorithm and uploads the information to a block chain;
and S4, inquiring the inoculation information and the traceability information of each vaccine dose through inquiry.
According to the further optimization of the technical scheme, the query module generates the two-dimensional code so as to facilitate query.
According to the technical scheme, the two-dimensional code is further optimized by the following steps:
s41, encrypting data;
s42, generating a digital signature;
and S43, generating the two-dimensional code.
In a further optimization of the technical solution, in step S43, a qrcode library of python is used to generate a corresponding two-dimensional code for the data.
In a further optimization of the present technical solution, the encryption algorithm in step S3 includes one of SM2, SM3, and SM4 encryption algorithms.
Different from the prior art, the technical scheme has the following advantages:
1. provides a national unified new crown vaccine information query and management platform.
2. The source tracing and injection information of the new corona vaccine is not easy to be falsified and forged.
3. The new crown vaccination voucher is not easy to be falsified and forged.
4. The national confidence level of the new corona vaccine is improved.
Drawings
FIG. 1 is a basic system framework;
FIG. 2 is a system hierarchy diagram;
FIG. 3 is a schematic diagram of data and Etherhouse interaction;
fig. 4 is a flowchart of generating the national secret two-dimensional code.
Detailed Description
To explain technical contents, structural features, and objects and effects of the technical solutions in detail, the following detailed description is given with reference to the accompanying drawings in conjunction with the embodiments.
A new crown vaccine information tracing method based on a block chain realizes the tracing of the new crown vaccine and the uplink and query of injection information, and comprises the following steps:
s1, linking production information, and packaging and uploading the production information of the new corona vaccine to a block chain by a manufacturer; the production information of the new corona vaccine comprises batch number, manufacturer number, production date, vaccine category and production place of the new corona vaccine.
S2, linking the transport information, and packaging and uploading the transport information of the new crown vaccine to a block chain by a transport company; the transportation information of the new corona vaccine comprises the batch number of the new corona vaccine, the serial number of a transportation company, the transportation time, the transit place, the transportation temperature and the vaccine state.
S3, linking the vaccination information, namely encrypting the vaccination information of the new crown vaccine related to the individual privacy of the citizen by using SM4 national cipher algorithm by the vaccination hospital, and packaging and uploading the information to a block chain; the vaccination information of the new corona vaccine comprises batch number of the new corona vaccine, hospital number for vaccination, doctor number for vaccination, vaccination time and times of vaccinating agent.
And S4, inquiring the inoculation information and the traceability information of each vaccine dose through inquiry. The query includes:
1. and (3) inquiring citizen information, wherein citizens can inquire historical vaccination information of citizens and source tracing information of each dose of vaccine to be vaccinated.
2. And the government has more inquiry authorities except the citizen inoculation information inquiry.
The government information inquiry authority comprises inquiring the personal information of citizens and the historical inoculation information of the citizens; inquiring the responsible person of the place of origin and the contact way thereof according to the name of the manufacturer and the place of origin; inquiring all vaccination information of the same batch of vaccines according to the batch number of the vaccines; inquiring all relevant information produced by the vaccine according to the batch number of the vaccine; and inquiring all relevant information of the transportation of the vaccine according to the batch number of the vaccine.
3. And (4) two-dimension code interaction, and safety conversion is carried out on citizen historical inoculation information and the two-dimension code certificate.
In the two-dimension code interaction process, citizen historical inoculation information is encrypted by SM2, SM3 and SM4 cryptographic algorithms to generate a two-dimension code; and after the two-dimensional code is scanned, the staff uses a corresponding algorithm for decryption, and then the historical inoculation information of the citizen can be obtained.
Referring to fig. 4, a flowchart of generating the national secret two-dimensional code is shown, where the two-dimensional code generation process includes the following steps:
s41, encrypting data; input data is block-encrypted with an application key generated using a random number.
S42, generating a digital signature; the digital signature is computed according to the SM2 digital signature algorithm using the server's private signature key.
S43, generating a two-dimensional code; the data is generated into a corresponding two-dimensional code using the qrcode library of python.
Referring to fig. 1, which is a basic framework diagram of a system, a block chain-based new crown vaccine information traceability system comprises.
A data acquisition module: the system is used for acquiring production information, transportation information and injection information of the new corona vaccine; and in the links of production, transportation and inoculation of the new crown vaccine, relevant information is recorded into the block chain.
The new crown vaccine information input system comprises a manufacturer role, a carrier role and an inoculation hospital role and is used for realizing the input of information.
A data storage module: and the data acquired by the data acquisition module is transmitted to the data storage module for storage.
The query module: the data storage module is used for inquiring the information stored by the data storage module and displaying the inquiry result to the inquirer. And inquiring new crown vaccine injection information and traceability information, and generating and scanning a national password two-dimensional code to be used as a vaccination voucher.
The information inquiry system of the new crown vaccine comprises a citizen role, a government role and a detector role, and is used for realizing information inquiry and generation and verification of the encrypted two-dimensional code.
The data storage module comprises a block chain and a relational database. The data acquisition module is connected with the query module through an Ether house block chain and a relational database, and numbers corresponding to the information stored in the storage area block chain in the database are stored. In this embodiment, an etherhouse block chain technique is used, an etherhouse alliance chain is established, and an account on the alliance chain is created for each role.
And an interface for information chaining and query is provided for the account on the alliance chain by writing an intelligent contract. And the user calls an intelligent contract interface function to realize the uplink and query of the new crown vaccine information. The inoculation information for generating the two-dimensional code is obtained by inquiring on the block chain, and the encryption algorithm makes the two-dimensional code not easy to be falsified or forged.
Referring to FIG. 2, a system hierarchy diagram is shown. The method comprises the following steps:
a data acquisition layer: the vaccine traceability information supports manual input at the pc end and the mobile end, and the scanning process of the two-dimensional code supports the realization of the domestic handheld Internet of things equipment.
A data storage layer: the storage is performed in a manner that a relational database is combined with a blockchain. The block chain of the data storage layer stores specific information of vaccine production, transport and injection to ensure that it is not tamper-proof. The relational database of the data storage layer stores account information of each role in the system, addresses, responsible persons, contact information of each production and transportation company, doctor information of a hospital and the like, so that the whole system can be managed conveniently.
Functional module layer: the system comprises a registration login module, an information input module, an information inquiry module and a two-dimensional code interaction module of a user.
An application layer: different business interfaces are provided for different objects, and the business interfaces comprise production side, transportation side, hospital side input interfaces, citizen and government inquiry interfaces and background management interfaces.
Referring to fig. 3, a schematic diagram of data and ether house interaction is shown. The interactive schematic of the production, transportation and injection data of the new crown vaccine and the Ethengfang comprises the following steps:
s21, the information uploader inputs the detailed information to be linked from the front page;
s22, the data is acquired by the back end and encrypted by SM4 cryptographic algorithm;
s23, calling the function submission information in the intelligent contract, issuing the function submission information to the block chain, returning the information number, and storing the information number in the database;
s24, after the user sends the inquiry request, the system will look for the corresponding number in the database first;
and S25, searching corresponding information on the block chain by using the serial number, and displaying the decrypted information to the user at the front end.
The innovation points of the invention are as follows:
1. and (3) system decentralization: the public database is maintained in a whole network in a collective way, and the data is transparent, cannot be tampered and has high reliability;
2. code disclosure auditable: the intelligent contract code, namely the law, is combined with the open source client code to guarantee reliable implementation;
3. the inoculation voucher is tamper-proof: a two-dimensional code generation and verification mechanism based on the SM2, SM3 and SM4 algorithms;
4. the tracing platform is efficient and safe: the five-party main body integrates production, transportation, inoculation, management and traceability processes.
It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or terminal that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or terminal. Without further limitation, an element defined by the phrases "comprising … …" or "comprising … …" does not exclude the presence of additional elements in a process, method, article, or terminal that comprises the element. Further, herein, "greater than," "less than," "more than," and the like are understood to exclude the present numbers; the terms "above", "below", "within" and the like are to be understood as including the number.
Although the embodiments have been described, once the basic inventive concept is obtained, other variations and modifications of these embodiments can be made by those skilled in the art, so that the above embodiments are only examples of the present invention, and not intended to limit the scope of the present invention, and all equivalent structures or equivalent processes using the contents of the present specification and drawings, or any other related technical fields, which are directly or indirectly applied thereto, are included in the scope of the present invention.

Claims (10)

1. The utility model provides a new crown bacterin information traceability system based on block chain which characterized in that includes, data acquisition module: the system is used for acquiring production information, transportation information and injection information of the new corona vaccine; a data storage module: the data acquired by the data acquisition module is transmitted to the data storage module for storage;
the query module: the data storage module is used for inquiring the information stored by the data storage module and displaying the inquiry result to the inquirer.
2. The blockchain-based new corona vaccine information traceability system of claim 1, wherein the data collection module comprises an internet of things device, a smart phone and a computer.
3. The blockchain-based new crown vaccine information traceability system of claim 1, wherein the data storage module comprises a relational database and a blockchain.
4. The blockchain-based new crown vaccine information traceability system of claim 3, wherein the blockchain uses etherhouse blockchain technology to build an etherhouse alliance chain and create an account on the alliance chain for the querier.
5. The blockchain-based new corona vaccine information traceability system of claim 1, wherein the query module generates a two-dimensional code for query.
6. A new crown vaccine information tracing method based on block chains is characterized by comprising the following steps,
s1, the vaccine manufacturer uploads the production information of the new corona vaccine to a block chain;
s2, the transportation company uploads the transportation information of the new crown vaccine to a block chain;
s3, the vaccination hospital encrypts the vaccination information of the new crown vaccine by using an encryption algorithm and uploads the information to a block chain;
and S4, inquiring the inoculation information and the traceability information of each vaccine dose through inquiry.
7. The blockchain-based new crown vaccine information tracing method according to claim 6, wherein the query module generates a two-dimensional code for query.
8. The method for tracing new crown vaccine information based on blockchain according to claim 8, wherein the two-dimensional code is generated by the following steps:
s41, encrypting data;
s42, generating a digital signature;
and S43, generating the two-dimensional code.
9. The blockchain-based new corona vaccine information tracing method according to claim 6, wherein said step S43 uses the qrcode library of python to generate the corresponding two-dimensional code for the data.
10. The blockchain-based new crown vaccine information tracing method according to claim 6, wherein the encryption algorithm in the step S3 includes one of SM2, SM3 and SM4 encryption algorithms.
CN202110845725.0A 2021-07-26 2021-07-26 New crown vaccine information tracing method and system based on block chain Pending CN113488192A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202110845725.0A CN113488192A (en) 2021-07-26 2021-07-26 New crown vaccine information tracing method and system based on block chain

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202110845725.0A CN113488192A (en) 2021-07-26 2021-07-26 New crown vaccine information tracing method and system based on block chain

Publications (1)

Publication Number Publication Date
CN113488192A true CN113488192A (en) 2021-10-08

Family

ID=77943785

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202110845725.0A Pending CN113488192A (en) 2021-07-26 2021-07-26 New crown vaccine information tracing method and system based on block chain

Country Status (1)

Country Link
CN (1) CN113488192A (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN205581980U (en) * 2016-04-29 2016-09-14 山东蓝海信息科技有限公司 Medical two -way north inquiry system that chases after based on thing networking
CN110717767A (en) * 2019-09-20 2020-01-21 谢坚 Anti-counterfeiting traceability system for vaccine prevention based on Internet of things and block chain
CN110992068A (en) * 2019-12-17 2020-04-10 浙江大学 Vaccine full life cycle management method and system based on block chain
CN112732836A (en) * 2021-01-13 2021-04-30 杭州甘道智能科技有限公司 Block chain-based vaccine validity period supervision method

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN205581980U (en) * 2016-04-29 2016-09-14 山东蓝海信息科技有限公司 Medical two -way north inquiry system that chases after based on thing networking
CN110717767A (en) * 2019-09-20 2020-01-21 谢坚 Anti-counterfeiting traceability system for vaccine prevention based on Internet of things and block chain
CN110992068A (en) * 2019-12-17 2020-04-10 浙江大学 Vaccine full life cycle management method and system based on block chain
CN112732836A (en) * 2021-01-13 2021-04-30 杭州甘道智能科技有限公司 Block chain-based vaccine validity period supervision method

Similar Documents

Publication Publication Date Title
US11743041B2 (en) Technologies for private key recovery in distributed ledger systems
CN108959945B (en) Medical data sharing method and device, computer readable medium and electronic equipment
CN105378649B (en) More permissions data safety and access
CN110414203A (en) A kind of internet medical treatment identity identifying method based on block chain technology
CN102236766B (en) Security data item level database encryption system
CN101098232B (en) Dynamic password and multiple biological characteristics combined identification authenticating method
CN110990407A (en) Block chain based data storage method and device, server and storage medium
EP2509275A1 (en) Method and system for authenticating entities by means of mobile terminals
CN102187618B (en) Method and apparatus for pseudonym generation and authentication
CN106657059A (en) Database query method and system having access control function
CN103281377A (en) Cryptograph data storage and searching method for cloud
CN105281902B (en) A kind of Web system safe login method based on mobile terminal
CN101924739A (en) Method for encrypting, storing and retrieving software certificate and private key
CN111191289A (en) Method for displaying and storing private data
CN106875325A (en) One kind can search for resume image
CN109035499A (en) A kind of electronic password lock authentication method based on dynamic password
CN102694650B (en) Secret key generating method based on identity encryption
EP3984161A1 (en) Cryptographic key generation using external entropy generation
CN115378966A (en) Intelligent medical online service system and intelligent medical online service method
Rahunathan et al. Efficient and Secure Interoperable Healthcare Information System Using Keyword Searchable and Role-Based Access Control in Cloud Environment
CN113488192A (en) New crown vaccine information tracing method and system based on block chain
Dhivya et al. Symptoms based treatment based on Personal Health Record using Cloud computing
CN110708161A (en) Method for mobile device signature
CN113963807A (en) Electronic immune passport supervision method based on block chain
Liu et al. Sharing and privacy in PHRs: Efficient policy hiding and update attribute-based encryption

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20211008

RJ01 Rejection of invention patent application after publication