CN113456529A - Phytosterol isostearate microcapsule for water-based cosmetics - Google Patents
Phytosterol isostearate microcapsule for water-based cosmetics Download PDFInfo
- Publication number
- CN113456529A CN113456529A CN202110909579.3A CN202110909579A CN113456529A CN 113456529 A CN113456529 A CN 113456529A CN 202110909579 A CN202110909579 A CN 202110909579A CN 113456529 A CN113456529 A CN 113456529A
- Authority
- CN
- China
- Prior art keywords
- phytosterol isostearate
- microcapsule
- isostearate
- phytosterol
- cyclodextrin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/738—Cyclodextrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/11—Encapsulated compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q13/00—Formulations or additives for perfume preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to a phytosterol isostearate microcapsule. The phytosterol isostearate microcapsule is a spherical microcapsule consisting of a phytosterol isostearate capsule core and a coating layer coating the capsule core. The phytosterol isostearate microcapsule has good water solubility, can be applied to various water-based cosmetics, and has very wide application prospect.
Description
[ technical field ] A method for producing a semiconductor device
The invention belongs to the technical field of cosmetics. In particular, the present invention relates to a phytosterol isostearate microcapsule for use in aqueous cosmetics.
[ background of the invention ]
The phytosterol has cholesterol-like structure, and can inhibit the absorption of cholesterol in intestinal tract and reduce the incidence of cardiovascular diseases. But the phytosterol has a cyclopentane perhydrophenanthrene structure, is insoluble in water and oil and is difficult to be directly absorbed and utilized by human bodies. Generally, the phytosterol ester is obtained by esterifying the phytosterol ester with fatty acid, and the esterified sterol ester has good fat solubility.
The phytosterol isostearate is an esterification product of phytosterol and isostearic acid, and has the effects of moisturizing, enhancing skin permeability, reducing rough skin, promoting skin metabolism and the like, so that the phytosterol isostearate becomes an excellent cosmetic raw material.
At present, the phytosterol isostearate is mainly applied to cosmetics such as creams, essential oils and masks. For example, CN109939025A discloses a skin cream containing phytosterol isostearate; CN110025506A discloses a lip balm containing phytosterol isostearate; CN110638674A discloses an eye cream containing phytosterol isostearate; CN107875054A discloses an essential oil containing phytosterol isostearate; CN112294712A discloses a lipstick containing phytosterol isostearate. However, phytosterol isostearate is not soluble in water, and cannot be directly applied to water-based cosmetics (such as toner, astringent, skin cleaning water, perfume and the like), and no water-based cosmetic product containing phytosterol isostearate is available at present.
Aiming at the technical problems in the prior art, the inventor finally completes the invention through a large number of experimental researches and analytical summarization on the basis of summarizing the prior art.
[ summary of the invention ]
[ problem to be solved ]
The invention aims to provide a phytosterol isostearate microcapsule for a water-based cosmetic.
[ solution ]
The invention is realized by the following technical scheme.
The invention relates to a phytosterol isostearate microcapsule for a water-based cosmetic.
The phytosterol isostearate microcapsule is a spherical microcapsule consisting of a phytosterol isostearate capsule core and a coating layer for coating the capsule core; the coating layer is composed of beta-cyclodextrin and soybean protein isolate.
According to a preferred embodiment of the present invention, the diameter of the phytosterol isostearate microcapsule is 5-30 μm.
According to another preferred embodiment of the invention, the thickness of the plant sterol isostearate microcapsule coating layer is 1-5 μm.
According to another preferred embodiment of the present invention, the weight ratio of beta-cyclodextrin to soy protein isolate is 1: 1.5 to 5.0.
According to another preferred embodiment of the invention, said beta-cyclodextrin is replaced by hydroxypropyl beta-cyclodextrin or other modified beta-cyclodextrin.
According to another preferred embodiment of the present invention, the capsule core is composed of plant sterol isostearate droplets or plant sterol isostearate micro-capsules having a diameter of 2 to 10 μm.
According to another preferred embodiment of the present invention, the phytosterol isostearate microcapsule is prepared by the following preparation method:
A. heating and melting the phytosterol isostearate at the temperature of 55-65 ℃, and uniformly stirring to obtain the phytosterol isostearate molten liquid;
B. dissolving beta-cyclodextrin and isolated soy protein in water according to the weight ratio of 1.5-5.0, and then stirring and mixing uniformly at the temperature of 45-65 ℃ to obtain a wall material solution;
C. adding the phytosterol isostearate molten liquid obtained in the step A into the wall material solution obtained in the step B, simultaneously keeping the temperature of the mixture solution at 45-65 ℃, stirring and emulsifying, and homogenizing for 3-5 times by using a homogenizer under the pressure of 30-40 MPa to obtain a homogenized liquid;
D. and D, using a spray dryer to spray dry the homogenized solution obtained in the step C, and screening to obtain the phytosterol isostearate microcapsule.
According to another preferred embodiment of the invention, in step B, said β -cyclodextrin is replaced by hydroxypropyl β -cyclodextrin or other modified β -cyclodextrin.
According to another preferred embodiment of the present invention, in the step C, the mixture solution is emulsified for 20 to 40min under the condition of stirring speed of 500 to 1000 rpm.
According to another preferred embodiment of the present invention, in the step D, the homogeneous liquid is spray-dried at an inlet temperature of 130 to 145 ℃ and an outlet temperature of 75 to 95 ℃ until the water content is 2% by weight or less.
The present invention will be described in more detail below.
The invention relates to a phytosterol isostearate microcapsule for a water-based cosmetic.
The microcapsule technology is to wrap dispersed solid, liquid and gas substances in a film to form a microcapsule structure. The microcapsule can embed liquid to form micro-particles, isolate active components, shield the odor of the embedded substance, protect the embedded substance sensitive to heat, oxygen, light, etc., and control the slow release or target site release of the embedded substance. The microcapsule technology can also make the substances which are originally insoluble in water have good water solubility, so the microcapsule technology is widely applied in a plurality of fields.
In the invention, the phytosterol isostearate microcapsule is a spherical microcapsule consisting of phytosterol isostearate serving as a capsule core and a coating layer coating the capsule core;
according to the invention, the diameter of the phytosterol isostearate spherical microcapsule is 5-30 mu m. The diameter is obtained by detecting the diameter by a laser diffraction method according to the standard of GB/T19077-2016 particle size analysis laser diffraction method.
If the diameter of the phytosterol isostearate spherical microcapsule is less than 5 mu m, the embedding effect of the phytosterol isostearate is poor, and the prepared microcapsule is unstable and easy to deteriorate; if the diameter of the phytosterol isostearate spherical microcapsule is more than 30 mu m, the water solubility of the prepared microcapsule is poor; therefore, the diameter of the phytosterol isostearate spherical microcapsule is reasonable to be 5-30 μm, and is preferably 8-25 μm; more preferably 12 to 20 μm;
according to the invention, the coating layer thickness of the phytosterol isostearate spherical microcapsule is 1-5 mu m. The thickness was measured using differential scanning calorimetry. For a specific method, see document 1: song Zhenghong et al, entitled "finding wall material thickness of microcapsules by differential scanning calorimetry," Proc. Tianjin university of Industrial science, (03), pp5-7, (2006).
If the thickness of the coating layer of the phytosterol isostearate spherical microcapsule is less than 1 mu m, the prepared microcapsule is easy to oxidize and deteriorate, and the shelf life of the product is short; if the thickness of the coating layer of the phytosterol isostearate spherical microcapsule is more than 5 mu m, the content of the phytosterol isostearate in the prepared microcapsule is lower; therefore, the coating thickness of the phytosterol isostearate spherical microcapsule is proper to be 1-5 μm, and preferably 2-4 μm;
the coating layer is composed of beta-cyclodextrin and soybean protein isolate. According to the invention, the weight ratio of beta-cyclodextrin to soy protein isolate is 1: 1.5 to 5.0.
Beta cyclodextrin is a polysaccharide with good water solubility, is a wall material component commonly used in the microcapsule technology, and has a certain nutritive value; the isolated soy protein has a protein content of above 90%, contains no cholesterol, is a vegetable protein capable of replacing animal protein, and has rich nutrition. Because of its excellent emulsifying, hydrating and film-forming properties, it can be used as a wall material in microcapsules.
If the weight ratio of the beta-cyclodextrin to the soy protein isolate is greater than 1: 1.5, a stable emulsifying system cannot be formed after the wall material mixed solution and the phytosterol isostearate molten liquid are mixed; if the weight ratio of beta-cyclodextrin to soy protein isolate is less than 1: 5.0, it is also difficult to form a stable emulsion system; thus, the weight ratio of beta-cyclodextrin to soy protein isolate is 1: 1.5 to 5.0 are suitable, preferably 1: 2.0 to 4.6, more preferably 1: 2.4 to 4.2;
the phytosterol isostearate used in the present invention is a product currently marketed, for example, by Shaanxi Haishi Schff bioengineering, Inc. under the trade name phytosterol isostearate. The beta-cyclodextrin and the isolated soy protein used in the present invention are commercially available products, such as beta-cyclodextrin sold under the trade name beta-cyclodextrin by Sigma-Aldrich, and isolated soy protein sold under the trade name isolated soy protein by Kazawa Biotech, Inc., Shandong.
In the present invention, any cyclodextrin which has the same properties as beta-cyclodextrin and which does not adversely affect the phytosterol isostearate spherical microcapsules of the present invention and their use is also contemplated as within the scope of the present invention, such as hydroxypropyl beta-cyclodextrin or other modified beta-cyclodextrin, for example, hydroxypropyl beta-cyclodextrin sold under the trade name hydroxypropyl beta-cyclodextrin by noontima biotechnology limited, shandong, modified beta-cyclodextrin sold under the trade name methyl beta-cyclodextrin by noontima biotechnology limited.
According to the invention, the capsule core is composed of phytosterol isostearate liquid drops or phytosterol isostearate micro capsules with the diameter of 2-10 mu m.
In the context of the present invention, a plant sterol isostearate droplet is understood to be a droplet formed from a plant sterol isostearate in the molten state at a temperature above 60 ℃;
the phytosterol isostearate microcapsule is understood to be a microcapsule which consists of phytosterol isostearate serving as a core solution and a beta cyclodextrin and soybean protein isolate coating layer which coat the core solution;
the diameters of the liquid drops and the micro capsules are 2-10 mu m, and the diameters of the liquid drops and the micro capsules exceeding the range are not preferable, because the liquid drops with large diameters cannot be completely embedded by wall materials, and the prepared microcapsules have the defects of easy oxidation and the like. Their diameters were determined by cryosectioning scanning electron microscopy. For a specific method, see document 2: SRwhite et al, entitled "Automic healthcare of Polymer composites," Nature, (409), pp794-797 (2001).
According to the invention, the phytosterol isostearate microcapsule is prepared by adopting the following preparation method:
A. heating and melting the phytosterol isostearate at the temperature of 55-65 ℃, and uniformly stirring to obtain the phytosterol isostearate molten liquid;
B. dissolving beta-cyclodextrin and isolated soy protein in water according to the weight ratio of 1.5-5.0, and then stirring and mixing uniformly at the temperature of 45-65 ℃ to obtain a wall material solution;
phytosterol isostearate, beta-cyclodextrin and soy protein isolate have been described previously and will not be described further herein.
According to the invention, the beta-cyclodextrin is replaced by hydroxypropyl beta-cyclodextrin or other modified beta-cyclodextrin.
C. Adding the phytosterol isostearate molten liquid obtained in the step A into the wall material solution obtained in the step B, simultaneously keeping the temperature of the mixture solution at 45-65 ℃, stirring and emulsifying, and homogenizing for 3-5 times by using a homogenizer under the pressure of 30-40 MPa to obtain a homogenized liquid;
the main purpose of maintaining the temperature of the mixture solution at 45-65 c according to the present invention is to ensure that the phytosterol isostearate remains liquid and does not cause oxidation due to the higher temperature.
The mixture solution is emulsified for 20-40 min under the condition of stirring speed of 500-1000. The stirring speed and the emulsifying time of the emulsifier exceeding the ranges are not preferable, because the poor emulsifying effect is caused by the too low stirring speed and the too short emulsifying time, and the emulsifying effect is also influenced by the too high stirring speed and the too long emulsifying time.
The main function of the mixture solution after emulsification and subsequent homogenization is to make the prepared emulsified system more stable.
When the invention uses the homogenizer for treatment, the times of homogenization treatment are 3-5 times, if the pressure of the homogenization treatment is lower than 30MPa, the emulsification system is not stable enough, and partial delamination can occur after standing for 1 h; if the pressure of the homogenization treatment is higher than 40MPa, the emulsification system is not stable enough, and partial layering occurs after standing for 1 h; therefore, the pressure for the homogenization treatment is preferably 30 to 40MPa, more preferably 33 to 36 MPa; when the pressure of the homogenization treatment is 30-40 MPa, if the number of times of the homogenization treatment is less than 3 times, the emulsification system is not stable enough, and partial layering can occur after the mixture is kept stand for 1 hour; the number of homogenization treatments more than 5 is not necessary; therefore, the number of homogenization treatments is appropriate;
the homogenizer used in the present invention is a product currently marketed, for example, by the Towa high pressure homogenizer factory in the Shanghai under the trade name high pressure homogenizer.
D. And D, using a spray dryer to spray dry the homogenized solution obtained in the step C, and screening to obtain the phytosterol isostearate microcapsule.
According to the invention, the homogeneous liquid is spray-dried at an inlet temperature of 130-145 ℃ and an outlet temperature of 75-95 ℃ until the water content is below 2% by weight.
In the invention, the water content is detected by a direct drying method according to GB/T5009.3-2016.
The spray drying equipment used in the present invention is a product currently marketed, for example, by Shanghai Voddi Automation Equipment Inc. under the trade name Experimental spray dryer.
The diameter of the phytosterol isostearate microcapsule is detected by a laser diffraction method according to the standard of GB/T19077-2016 particle size analysis laser diffraction method.
The thickness of the phytosterol isostearate microcapsule coating layer according to the present invention was measured according to the method described in the above document 1.
The application of the phytosterol isostearate microcapsule in the water-based cosmetics is tested as follows:
water solubility test: accurately weighing 100ml of purified water, adding the purified water into a beaker, placing the beaker into an ultrasonic water bath, and adding the phytosterol isostearate microcapsule into the beaker one by one until the microcapsule can not be completely dissolved within 10min, wherein the unit of the addition of the phytosterol isostearate microcapsule is g/100 ml.
Specifically, the experiment was performed in two parallel sets, and the mean of the solubilities of the three experiments was taken as the solubility.
The solubility of the phytosterol isostearate microcapsule in water is 21g/100 ml.
The same test was also conducted using a currently marketed yulan oil water-based cosmetic moisturizer: 100ml of magnolia oil moisturizer is taken to test the solubility of the phytosterol isostearate microcapsule provided by the invention.
The mean of the results of three experiments was taken as solubility: the solubility of the phytosterol isostearate microcapsule of the invention in the microcapsule is 17.1g/100 ml.
[ advantageous effects ]
The invention has the beneficial effects that:
the water-insoluble phytosterol isostearate is prepared into the water-soluble phytosterol isostearate microcapsule, so that the water-soluble phytosterol isostearate microcapsule can be applied to water-based cosmetics, and the application of the phytosterol isostearate in the field of cosmetics is expanded.
[ detailed description ] embodiments
The invention will be better understood from the following examples.
Example 1: the invention relates to phytosterol isostearate microcapsule
The implementation of this example is as follows:
the phytosterol isostearate microcapsule is a spherical microcapsule consisting of a phytosterol isostearate capsule core and a coating layer for coating the capsule core;
the capsule core is composed of phytosterol isostearate liquid drops with the diameter of 7 mu m;
the wrapping layer is prepared from beta-cyclodextrin and soybean protein isolate according to the weight ratio of 1: 2.5.
The phytosterol isostearate microcapsule is prepared by adopting the following preparation method:
A. heating and melting phytosterol isostearate sold under the trade name of phytosterol isostearate by Shaanxi Haishi Sff bioengineering limited company at the temperature of 62 ℃, and uniformly stirring to obtain the phytosterol isostearate molten liquid;
B. beta-cyclodextrin sold under the trade name of beta-cyclodextrin by Sigma-Aldrich and soybean protein isolate sold under the trade name of soybean protein isolate by yanto carvachin, inc in a weight ratio of 1: 2.5 dissolving in water, and then stirring and mixing uniformly at the temperature of 45 ℃ to obtain a wall material solution;
C. adding the phytosterol isostearate melt solution obtained in the step A into the wall material solution obtained in the step B, keeping the temperature of the mixture solution at 45 ℃, emulsifying for 20min under the condition of stirring speed of 500rpm, and homogenizing for 3 times under the condition of pressure of 30MPa by using a homogenizer sold under the trade name of high-pressure homogenizer from Shanghai Donghua high-pressure homogenizer factory to obtain a homogenized solution;
D. using a spray dryer sold under the trade name of an experimental spray dryer by Shanghai Vondi Automation equipments Ltd, spray-drying the homogenized solution obtained in step C at an inlet temperature of 140 ℃ and an outlet temperature of 95 ℃ until the water content is 2% by weight or less, and sieving to obtain the phytosterol isostearate microcapsule.
The diameter of the phytosterol isostearate microcapsules was 14 μm and the thickness of the coating was 5 μm, as measured by the method described in the specification.
Example 2: the invention relates to phytosterol isostearate microcapsule
The implementation of this example is as follows:
the phytosterol isostearate microcapsule is a spherical microcapsule consisting of a phytosterol isostearate capsule core and a coating layer for coating the capsule core;
the capsule core is composed of phytosterol isostearate liquid drops with the diameter of 2 mu m;
the wrapping layer is prepared from beta-cyclodextrin and soybean protein isolate according to the weight ratio of 1: 1.5.
The phytosterol isostearate microcapsule is prepared by adopting the following preparation method:
A. heating and melting phytosterol isostearate sold under the trade name of phytosterol isostearate by Shaanxi Haishi Sff bioengineering limited company at the temperature of 65 ℃, and uniformly stirring to obtain the phytosterol isostearate molten liquid;
B. beta-cyclodextrin sold under the trade name of beta-cyclodextrin by Jiangsu Fengyuan biotechnology limited and soybean protein isolate sold under the trade name of soybean protein isolate by Shandong Jiahua Biotech Co., Ltd are mixed in a weight ratio of 1: 1.5 dissolving in water, and then stirring and mixing uniformly at the temperature of 58 ℃ to obtain a wall material solution;
C. adding the phytosterol isostearate melt solution obtained in the step A into the wall material solution obtained in the step B, keeping the temperature of the mixture solution at 58 ℃, emulsifying for 30min under the condition of stirring speed of 1000rpm, and homogenizing for 4 times under the condition of pressure of 35MPa by using a homogenizer sold under the trade name of high-pressure homogenizer from Shanghai Donghua high-pressure homogenizer factory to obtain a homogenized solution;
D. using a spray dryer sold under the trade name of an experimental spray dryer by Shanghai Vondi Automation equipments Ltd, spray-drying the homogenized solution obtained in step C at an inlet temperature of 130 ℃ and an outlet temperature of 75 ℃ until the water content is 1% by weight or less, and sieving to obtain the phytosterol isostearate microcapsule.
The diameter of the phytosterol isostearate microcapsules was 22 μm and the thickness of the coating was 1 μm, as measured by the method described in the specification.
Example 3: the invention relates to phytosterol isostearate microcapsule
The implementation of this example is as follows:
the phytosterol isostearate microcapsule is a spherical microcapsule consisting of a phytosterol isostearate capsule core and a coating layer for coating the capsule core;
the capsule core is composed of phytosterol isostearate micro capsules with the diameter of 4 mu m; the phytosterol isostearate microcapsule is composed of a core solution which is phytosterol isostearate, and a beta-cyclodextrin and soybean protein isolate coating layer which coat the core solution.
The wrapping layer is prepared from beta-cyclodextrin and soybean protein isolate according to the weight ratio of 1: 3.8 of the composition.
The phytosterol isostearate microcapsule is prepared by adopting the following preparation method:
A. heating and melting phytosterol isostearate sold under the trade name of phytosterol isostearate by Shaanxi Haishi Sff bioengineering limited company at the temperature of 55 ℃, and uniformly stirring to obtain the phytosterol isostearate molten liquid;
B. beta-cyclodextrin sold under the trade name of beta-cyclodextrin by Jiangsu Fengyuan biotechnology limited and soybean protein isolate sold under the trade name of soybean protein isolate by Shandong Jiahua Biotech Co., Ltd are mixed in a weight ratio of 1: 3.8 dissolving in water, and then stirring and mixing uniformly at the temperature of 65 ℃ to obtain a wall material solution;
C. adding the phytosterol isostearate melt solution obtained in the step A into the wall material solution obtained in the step B, keeping the temperature of the mixture solution at 65 ℃, emulsifying for 40min under the condition of stirring speed of 600rpm, and homogenizing for 5 times under the condition of pressure of 40MPa by using a homogenizer sold under the trade name of high-pressure homogenizer from Shanghai Donghua high-pressure homogenizer factory to obtain a homogenized solution;
D. using a spray dryer sold under the trade name of experimental type spray dryer by shanghai vody automated equipment ltd, spray-drying the homogenized liquid obtained in step C at an inlet temperature of 135 ℃ and an outlet temperature of 82 ℃ until the water content is 1.5% by weight or less, and sieving to obtain the phytosterol isostearate microcapsules.
The diameter of the phytosterol isostearate microcapsules was 30 μm and the thickness of the coating was 4 μm, as measured by the method described in the specification.
Example 4: the invention relates to phytosterol isostearate microcapsule
The implementation of this example is as follows:
the phytosterol isostearate microcapsule is a spherical microcapsule consisting of a phytosterol isostearate capsule core and a coating layer for coating the capsule core;
the capsule core is composed of phytosterol isostearate micro capsules with the diameter of 10 mu m; the phytosterol isostearate microcapsule is composed of a core solution taking phytosterol isostearate as a core solution and a coating layer of beta-cyclodextrin and soybean protein isolate coating the core solution
The wrapping layer is prepared from beta-cyclodextrin and soybean protein isolate according to the weight ratio of 1: 5.0.
The phytosterol isostearate microcapsule is prepared by adopting the following preparation method:
A. heating and melting phytosterol isostearate sold under the trade name of phytosterol isostearate by Shaanxi Haishi Sff bioengineering limited company at the temperature of 58 ℃, and uniformly stirring to obtain the phytosterol isostearate molten liquid;
B. beta-cyclodextrin sold under the trade name of beta-cyclodextrin by Jiangsu Fengyuan biotechnology limited and soybean protein isolate sold under the trade name of soybean protein isolate by Shandong Jiahua Biotech Co., Ltd are mixed in a weight ratio of 1: 5.0 is dissolved in water, and then is stirred and mixed evenly at the temperature of 52 ℃ to obtain a wall material solution;
C. adding the phytosterol isostearate melt solution obtained in the step A into the wall material solution obtained in the step B, keeping the temperature of the mixture solution at 52 ℃, emulsifying for 30min under the condition of stirring speed of 800rpm, and homogenizing for 4 times under the condition of pressure of 35MPa by using a homogenizer sold under the trade name of high-pressure homogenizer from Shanghai Donghua high-pressure homogenizer factory to obtain a homogenized solution;
D. using a spray dryer sold under the trade name of an experimental spray dryer by Shanghai Vondi Automation equipments Ltd, spray-drying the homogenized liquid obtained in step C at an inlet temperature of 145 ℃ and an outlet temperature of 88 ℃ until the water content is 0.5% by weight or less, and sieving to obtain the phytosterol isostearate microcapsules.
The diameter of the phytosterol isostearate microcapsules was 5 μm and the thickness of the coating was 2 μm, as measured by the method described in the specification.
Application example 1:
100ml of Douglas cosmetic essence cosmetic water was put in a beaker, 5g of the phytosterol isostearate microcapsules prepared in example 1 were added, the beaker was placed in an ultrasonic water bath at 20 ℃ for 15min, and then the beaker was taken out and allowed to stand at 20 ℃ for 24 h. The solution system was found to be uniform and clear, and no insoluble material was precipitated.
Application example 1 comparative example:
100ml of Douglas cosmetic essence cosmetic water was taken and placed in a beaker, 0.5g of the phytosterol isostearate used in example 1 was added to the beaker, the beaker was placed in an ultrasonic water bath at 20 ℃ for 15min, and then the beaker was taken out and left to stand at 20 ℃ for 24 hours. The phytosterol isostearate was observed to float as a viscous cream solid on top of the solution.
Application example 2:
100ml of Limax stock solution toner manufactured by Henan Ruizi biotechnology Limited is put into a beaker, 5g of the phytosterol isostearate microcapsule prepared in example 2 is added into the beaker, the beaker is put into an ultrasonic water bath at 20 ℃ for 15min, and then the beaker is taken out and is kept stand for 24h at 20 ℃. The solution system was found to be uniform and clear, and no insoluble material was precipitated.
Application example 2 comparative example:
100ml of Limax stock solution toner as declared by Henan Zhi Biotechnology Limited is put into a beaker, 0.5g of the phytosterol isostearate used in example 2 is added into the beaker, the beaker is put into an ultrasonic water bath at 20 ℃ for 15min, and then the beaker is taken out and is kept stand for 24h at 20 ℃. The phytosterol isostearate was observed to float as a viscous cream solid on top of the solution.
Application example 3:
50ml of a perfume having fresh scent of Kaempferia galangal (Chanel) was placed in a beaker, 3g of the phytosterol isostearate microcapsules prepared in example 3 were added, the beaker was placed in an ultrasonic water bath at 20 ℃ for 15min, and then the beaker was taken out and left to stand at 20 ℃ for 24 h. The solution system was found to be uniform and clear, and no insoluble material was precipitated.
Application example 3 comparative example:
50ml of a perfume having fresh scent encountered by a galangal (Chanel) was placed in a beaker, 3g of the phytosterol isostearate used in example 3 was added, the beaker was placed in an ultrasonic water bath at 20 ℃ for 15min, and then the beaker was taken out and left to stand at 20 ℃ for 24 h. The phytosterol isostearate was observed to float as a viscous cream solid on top of the solution.
Application example 4:
50ml of lanocoma (Lancome) wonderful perfume was placed in a beaker, 3g of the phytosterol isostearate microcapsules prepared in example 4 were added, the beaker was placed in an ultrasonic water bath at 20 ℃ for 15min, and then the beaker was taken out and allowed to stand at 20 ℃ for 24 h. The solution system was found to be uniform and clear, and no insoluble material was precipitated.
Application example 4 comparative example:
50ml of lanoco (LanOME) wonderful perfume was placed in a beaker, 3g of the phytosterol isostearate used in example 4 was added, the beaker was placed in an ultrasonic water bath at 20 ℃ for 15min, and then the beaker was taken out and allowed to stand at 20 ℃ for 24 h. The phytosterol isostearate was observed to float as a viscous cream solid on top of the solution.
The results of application examples 1 to 4 and comparative examples thereof clearly show that the product phytosterol isostearic acid microcapsules of the invention have good solubility in water-based cosmetics such as astringent, perfume and the like, and can be applied to different water-based cosmetics.
Claims (10)
1. A phytosterol isostearate microcapsule for water system cosmetics is characterized in that the phytosterol isostearate microcapsule is a spherical microcapsule consisting of a phytosterol isostearate capsule core and a coating layer for coating the capsule core; the coating layer is composed of beta-cyclodextrin and soybean protein isolate.
2. The phytosterol isostearate microcapsule according to claim 1 which has a diameter of 5-30 μm.
3. The phytosterol isostearate microcapsule according to claim 1 wherein the thickness of the coating layer is 1-5 μm.
4. The phytosterol isostearate microcapsule according to claim 1 wherein the weight ratio of beta-cyclodextrin to soy protein isolate is from 1: 1.5 to 5.0.
5. The phytosterol isostearate microcapsule according to claim 1 or 4 wherein the beta cyclodextrin is replaced with hydroxypropyl beta cyclodextrin or other modified beta cyclodextrin.
6. The phytosterol isostearate microcapsule according to claim 1 wherein the capsule core is composed of phytosterol isostearate droplets or phytosterol isostearate microcapsules with a diameter of 2-10 μm.
7. Plant sterol isostearate microcapsules according to any one of claims 1 to 6, characterized in that they are prepared by the following preparation method:
A. heating and melting the phytosterol isostearate at the temperature of 55-65 ℃, and uniformly stirring to obtain the phytosterol isostearate molten liquid;
B. dissolving beta-cyclodextrin and isolated soy protein in water according to the weight ratio of 1.5-5.0, and then stirring and mixing uniformly at the temperature of 45-65 ℃ to obtain a wall material solution;
C. adding the phytosterol isostearate molten liquid obtained in the step A into the wall material solution obtained in the step B, simultaneously keeping the temperature of the mixture solution at 45-65 ℃, stirring and emulsifying, and homogenizing for 3-5 times by using a homogenizer under the pressure of 30-40 MPa to obtain a homogenized liquid;
D. and D, using a spray dryer to spray dry the homogenized solution obtained in the step C, and screening to obtain the phytosterol isostearate microcapsule.
8. The phytosterol isostearate microcapsule according to claim 7 wherein in step B the beta-cyclodextrin is replaced with hydroxypropyl beta-cyclodextrin or other modified beta-cyclodextrin.
9. The phytosterol isostearate microcapsule according to claim 7 wherein in step C, the mixture solution is emulsified for 20-40 min at a stirring speed of 500-1000 rpm.
10. The phytosterol isostearate microcapsule according to claim 7 wherein in step D the homogenized mixture is spray dried at an inlet temperature of 130-145 ℃ and an outlet temperature of 75-95 ℃ to a water content of less than 2% by weight.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110909579.3A CN113456529A (en) | 2021-08-09 | 2021-08-09 | Phytosterol isostearate microcapsule for water-based cosmetics |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110909579.3A CN113456529A (en) | 2021-08-09 | 2021-08-09 | Phytosterol isostearate microcapsule for water-based cosmetics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113456529A true CN113456529A (en) | 2021-10-01 |
Family
ID=77867610
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110909579.3A Pending CN113456529A (en) | 2021-08-09 | 2021-08-09 | Phytosterol isostearate microcapsule for water-based cosmetics |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113456529A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090004333A1 (en) * | 2007-06-27 | 2009-01-01 | Bunge Oils, Inc. | Microencapsulated Oil Product and Method of Making Same |
| CN102613577A (en) * | 2012-04-19 | 2012-08-01 | 西安海斯夫生物科技有限公司 | Water-soluble phytosterol unsaturated fatty acid microcapsule and preparation method of water-soluble phytosterol unsaturated fatty acid microcapsule |
| CN105124604A (en) * | 2015-09-18 | 2015-12-09 | 华南理工大学 | High-dispersion phytosterol ester microcapsule, as well as preparation method and application thereof |
| CN109846039A (en) * | 2018-12-27 | 2019-06-07 | 延边大学 | The preparation method of phytosterol microcapsules |
| CN110721643A (en) * | 2019-09-27 | 2020-01-24 | 广东蔚莱生物科技有限公司 | Phytosterol ester microcapsule and preparation method and application thereof |
-
2021
- 2021-08-09 CN CN202110909579.3A patent/CN113456529A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090004333A1 (en) * | 2007-06-27 | 2009-01-01 | Bunge Oils, Inc. | Microencapsulated Oil Product and Method of Making Same |
| CN102613577A (en) * | 2012-04-19 | 2012-08-01 | 西安海斯夫生物科技有限公司 | Water-soluble phytosterol unsaturated fatty acid microcapsule and preparation method of water-soluble phytosterol unsaturated fatty acid microcapsule |
| CN105124604A (en) * | 2015-09-18 | 2015-12-09 | 华南理工大学 | High-dispersion phytosterol ester microcapsule, as well as preparation method and application thereof |
| CN109846039A (en) * | 2018-12-27 | 2019-06-07 | 延边大学 | The preparation method of phytosterol microcapsules |
| CN110721643A (en) * | 2019-09-27 | 2020-01-24 | 广东蔚莱生物科技有限公司 | Phytosterol ester microcapsule and preparation method and application thereof |
Non-Patent Citations (3)
| Title |
|---|
| 汪多仁: "《绿色医药化学品》", 31 July 2008, 科学技术文献出版社 * |
| 薛文通等: "微胶囊核桃粉加工工艺的研究", 《农业工程学报》 * |
| 陈小威等: "微胶囊技术及其在功能性食品中应用的研究进展", 《农产品加工(学刊)》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Kemala et al. | Preparation and characterization of microspheres based on blend of poly (lactic acid) and poly (ɛ-caprolactone) with poly (vinyl alcohol) as emulsifier | |
| Prieto et al. | Supercritical fluid extraction of emulsions to nanoencapsulate vitamin E in polycaprolactone | |
| Aghbashlo et al. | The correlation of wall material composition with flow characteristics and encapsulation behavior of fish oil emulsion | |
| Bai et al. | Development and characterization of soybean oil microcapsules employing kafirin and sodium caseinate as wall materials | |
| Huang et al. | Microencapsulation of extract containing shikonin using gelatin–acacia coacervation method: a formaldehyde-free approach | |
| CN102822413A (en) | Process of treatment of fibers and/or textile materials | |
| EP3272398A1 (en) | Lipid nanoparticle capsules | |
| Karim et al. | Microencapsulation of fish oil using supercritical antisolvent process | |
| CN110743472B (en) | Essential oil microcapsule composition, essential oil microcapsule and preparation method thereof | |
| CA2376818A1 (en) | Use of nanoscale sterols and sterol esters | |
| KR20020070279A (en) | A Method of Microencapsulation | |
| JP4982178B2 (en) | Microencapsulation system and its application | |
| Komijani et al. | Assembly of electrospun tri-layered nanofibrous structure of zein/basil seed gum/zein for increasing the bioaccessibility of lycopene | |
| de Melo Ramos et al. | Assessing the vacuum spray drying effects on the properties of orange essential oil microparticles | |
| Shanshan et al. | Fabrication of ovalbumin-burdock polysaccharide complexes as interfacial stabilizers for nanostructured lipid carriers: Effects of high-intensity ultrasound treatment | |
| Zhu et al. | Preparation and characterization of long-term antibacterial and pH-responsive Polylactic acid/Octenyl succinic anhydride-chitosan@ tea tree oil microcapsules | |
| Yu et al. | Preparation and properties of olive oil microcapsules | |
| CN108192731B (en) | Sweet orange essence-silk fibroin microcapsule and preparation method thereof | |
| Surini et al. | Gel formulation containing microcapsules of grape seed oil (Vitis vinifera L.) for skin moisturizer | |
| CN107242999A (en) | A kind of multiple self-emulsifying carrier of solid and preparation method thereof | |
| Loughrill et al. | Controlled release of microencapsulated docosahexaenoic acid (DHA) by spray–drying processing | |
| Zhang et al. | Preparation of natural composite microcapsules containing orchid black currant fragrance and its sustained-release properties on hair bundle | |
| EP3883394A2 (en) | Multi-layered particles | |
| CN113426389B (en) | Preparation method of alcohol soluble protein microcapsule and product | |
| CN109010885A (en) | A kind of essence emulsion gel composition and its preparation and application |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20220621 Address after: 712100 C1, torch Park, free trade street, Yangling Demonstration Zone, Xi'an City, Shaanxi Province Applicant after: SHAANXI HEALTHFUL BIOLOGICAL ENGINEERING Co.,Ltd. Address before: 710100 804, block a, Huihang Plaza, Hangtuo Road, aerospace base, Chang'an District, Xi'an City, Shaanxi Province Applicant before: XI'AN HEALTHFUL BIOTECHNOLOGY Co.,Ltd. |
|
| TA01 | Transfer of patent application right | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20211001 |
|
| RJ01 | Rejection of invention patent application after publication |