CN113455650A - Instant lactobacillus preparation for regulating gastrointestinal flora, relieving constipation and improving immunity - Google Patents
Instant lactobacillus preparation for regulating gastrointestinal flora, relieving constipation and improving immunity Download PDFInfo
- Publication number
- CN113455650A CN113455650A CN202110761722.9A CN202110761722A CN113455650A CN 113455650 A CN113455650 A CN 113455650A CN 202110761722 A CN202110761722 A CN 202110761722A CN 113455650 A CN113455650 A CN 113455650A
- Authority
- CN
- China
- Prior art keywords
- lactobacillus
- parts
- preparation
- instant
- relieving constipation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 39
- 241000186660 Lactobacillus Species 0.000 title claims abstract description 23
- 229940039696 lactobacillus Drugs 0.000 title claims abstract description 23
- 230000001105 regulatory effect Effects 0.000 title claims abstract description 22
- 230000002496 gastric effect Effects 0.000 title claims abstract description 21
- 230000036039 immunity Effects 0.000 title claims abstract description 21
- 206010010774 Constipation Diseases 0.000 title claims abstract description 20
- 229920001202 Inulin Polymers 0.000 claims abstract description 20
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 claims abstract description 20
- 229940029339 inulin Drugs 0.000 claims abstract description 20
- DLRVVLDZNNYCBX-RTPHMHGBSA-N isomaltose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)C(O)O1 DLRVVLDZNNYCBX-RTPHMHGBSA-N 0.000 claims abstract description 20
- FTSSQIKWUOOEGC-RULYVFMPSA-N fructooligosaccharide Chemical compound OC[C@H]1O[C@@](CO)(OC[C@@]2(OC[C@@]3(OC[C@@]4(OC[C@@]5(OC[C@@]6(OC[C@@]7(OC[C@@]8(OC[C@@]9(OC[C@@]%10(OC[C@@]%11(O[C@H]%12O[C@H](CO)[C@@H](O)[C@H](O)[C@H]%12O)O[C@H](CO)[C@@H](O)[C@@H]%11O)O[C@H](CO)[C@@H](O)[C@@H]%10O)O[C@H](CO)[C@@H](O)[C@@H]9O)O[C@H](CO)[C@@H](O)[C@@H]8O)O[C@H](CO)[C@@H](O)[C@@H]7O)O[C@H](CO)[C@@H](O)[C@@H]6O)O[C@H](CO)[C@@H](O)[C@@H]5O)O[C@H](CO)[C@@H](O)[C@@H]4O)O[C@H](CO)[C@@H](O)[C@@H]3O)O[C@H](CO)[C@@H](O)[C@@H]2O)[C@@H](O)[C@@H]1O FTSSQIKWUOOEGC-RULYVFMPSA-N 0.000 claims abstract description 19
- 229940107187 fructooligosaccharide Drugs 0.000 claims abstract description 19
- VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 claims abstract description 19
- 239000000832 lactitol Substances 0.000 claims abstract description 19
- 229960003451 lactitol Drugs 0.000 claims abstract description 19
- 235000010448 lactitol Nutrition 0.000 claims abstract description 19
- 241000186016 Bifidobacterium bifidum Species 0.000 claims abstract description 18
- 229920001353 Dextrin Polymers 0.000 claims abstract description 18
- 239000004375 Dextrin Substances 0.000 claims abstract description 18
- 240000001046 Lactobacillus acidophilus Species 0.000 claims abstract description 18
- 235000013956 Lactobacillus acidophilus Nutrition 0.000 claims abstract description 18
- 241000186605 Lactobacillus paracasei Species 0.000 claims abstract description 18
- 240000006024 Lactobacillus plantarum Species 0.000 claims abstract description 18
- 235000013965 Lactobacillus plantarum Nutrition 0.000 claims abstract description 18
- 241000218588 Lactobacillus rhamnosus Species 0.000 claims abstract description 18
- UQZIYBXSHAGNOE-USOSMYMVSA-N Stachyose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H](CO[C@@H]2[C@@H](O)[C@@H](O)[C@@H](O)[C@H](CO)O2)O1 UQZIYBXSHAGNOE-USOSMYMVSA-N 0.000 claims abstract description 18
- 229940002008 bifidobacterium bifidum Drugs 0.000 claims abstract description 18
- 235000019425 dextrin Nutrition 0.000 claims abstract description 18
- 229940039695 lactobacillus acidophilus Drugs 0.000 claims abstract description 18
- 229940072205 lactobacillus plantarum Drugs 0.000 claims abstract description 18
- UQZIYBXSHAGNOE-XNSRJBNMSA-N stachyose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO[C@@H]3[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O3)O)O2)O)O1 UQZIYBXSHAGNOE-XNSRJBNMSA-N 0.000 claims abstract description 18
- 239000002994 raw material Substances 0.000 claims abstract description 14
- 238000002156 mixing Methods 0.000 claims description 30
- 238000003756 stirring Methods 0.000 claims description 20
- 239000000843 powder Substances 0.000 claims description 16
- 238000001035 drying Methods 0.000 claims description 14
- 238000004806 packaging method and process Methods 0.000 claims description 10
- 238000007873 sieving Methods 0.000 claims description 10
- 235000016709 nutrition Nutrition 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 235000015097 nutrients Nutrition 0.000 claims description 5
- 230000035764 nutrition Effects 0.000 claims description 5
- 238000010298 pulverizing process Methods 0.000 claims description 5
- 238000007789 sealing Methods 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 235000013376 functional food Nutrition 0.000 claims description 2
- 235000013402 health food Nutrition 0.000 claims 1
- 235000013305 food Nutrition 0.000 abstract description 7
- 206010012735 Diarrhoea Diseases 0.000 abstract description 4
- 206010019375 Helicobacter infections Diseases 0.000 abstract description 3
- 208000007107 Stomach Ulcer Diseases 0.000 abstract description 3
- 201000005917 gastric ulcer Diseases 0.000 abstract description 3
- 239000000203 mixture Substances 0.000 abstract description 3
- 208000010643 digestive system disease Diseases 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 9
- 238000002474 experimental method Methods 0.000 description 9
- 239000006041 probiotic Substances 0.000 description 8
- 235000018291 probiotics Nutrition 0.000 description 8
- 241000590002 Helicobacter pylori Species 0.000 description 7
- 239000003814 drug Substances 0.000 description 7
- 229940037467 helicobacter pylori Drugs 0.000 description 7
- 239000007787 solid Substances 0.000 description 7
- 235000013361 beverage Nutrition 0.000 description 6
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 6
- 230000000529 probiotic effect Effects 0.000 description 6
- 230000001580 bacterial effect Effects 0.000 description 4
- 230000000968 intestinal effect Effects 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 210000001035 gastrointestinal tract Anatomy 0.000 description 3
- 239000001963 growth medium Substances 0.000 description 3
- 238000000338 in vitro Methods 0.000 description 3
- 235000014655 lactic acid Nutrition 0.000 description 3
- 239000004310 lactic acid Substances 0.000 description 3
- 230000035755 proliferation Effects 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 241000721047 Danaus plexippus Species 0.000 description 2
- 208000018522 Gastrointestinal disease Diseases 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000004535 effect on gastrointestinal diseases Effects 0.000 description 2
- 208000002551 irritable bowel syndrome Diseases 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000009630 liquid culture Methods 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 230000009044 synergistic interaction Effects 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 1
- 241000588921 Enterobacteriaceae Species 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 210000004347 intestinal mucosa Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000008621 organismal health Effects 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 235000013406 prebiotics Nutrition 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- 239000011241 protective layer Substances 0.000 description 1
- 238000003753 real-time PCR Methods 0.000 description 1
- 101150063569 slgA gene Proteins 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
- A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/113—Acidophilus
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/169—Plantarum
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/175—Rhamnosus
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/51—Bifidobacterium
- A23V2400/517—Bifidum
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Molecular Biology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses an instant lactobacillus preparation for regulating gastrointestinal flora, relieving constipation and improving immunity, belonging to the field of food. The composition comprises the following raw materials in parts by weight: 40-60 parts of isomaltooligosaccharide, 15-25 parts of lactitol, 13-18 parts of resistant dextrin, 8-12 parts of fructo-oligosaccharide, 1-5 parts of inulin, 0.1-1 part of lactobacillus rhamnosus, 0.1-0.6 part of lactobacillus plantarum, 0.01-0.6 part of lactobacillus acidophilus, 0.01-0.5 part of lactobacillus paracasei, 0.01-0.5 part of bifidobacterium bifidum and 0.01-0.5 part of stachyose. Also provides a preparation method and application thereof. The invention has synergistic effect on the regulation of diarrhea, helicobacter pylori infection, gastric ulcer and other digestive system diseases.
Description
Technical Field
The invention belongs to the field of food, and particularly relates to an instant lactobacillus preparation for regulating gastrointestinal flora, relieving constipation and improving immunity.
Background
At present, with the understanding and attention of people on gastrointestinal diseases, health-care foods for treating or intervening in gastrointestinal diseases on the market are diversified, and the effects are all emphasized.
However, the symptoms of gastrointestinal patients often coexist in a plurality of symptoms, and the existing products are difficult to avoid one another in intervention, and have different defects, for example, the probiotic solid beverage in the prior art has the quality stability and the intervention effect on gastrointestinal diseases at risk because only basic factory test and type 1 test per year are required for the probiotic solid beverage.
The quality of the ready-to-eat lactic acid bacteria is more strictly controlled, the delivery inspection requirements comprise items such as sense, net content, moisture, heavy metal, acid production activity or fermentation acidity, total number of lactic acid bacteria, enterobacteriaceae, mould and yeast, and the detection times are more every year. Each batch of factory product needs to meet mandatory standards. The stability of the product is guaranteed.
Therefore, the technical personnel in the field need to solve the problem that how to provide an instant lactobacillus preparation, which has no obvious side effect, has the synergistic interaction among the components, can well improve diarrhea, helicobacter pylori infection and gastric ulcer, and is convenient to carry and eat.
Disclosure of Invention
In view of the above, the invention provides an instant lactobacillus preparation for regulating gastrointestinal flora, relieving constipation and improving immunity. On one hand, intestinal flora can be adjusted, on the other hand, the immunity can be obviously improved, and the product is more stable.
In order to achieve the purpose, the invention adopts the following technical scheme:
an instant lactobacillus preparation for regulating gastrointestinal flora, relieving constipation and improving immunity comprises the following raw materials in parts by weight: 40-60 parts of isomaltooligosaccharide, 15-25 parts of lactitol, 13-18 parts of resistant dextrin, 8-12 parts of fructo-oligosaccharide, 1-5 parts of inulin, 0.1-1 part of lactobacillus rhamnosus, 0.1-0.6 part of lactobacillus plantarum, 0.01-0.6 part of lactobacillus acidophilus, 0.01-0.5 part of lactobacillus paracasei, 0.01-0.5 part of bifidobacterium bifidum and 0.01-0.5 part of stachyose.
Preferably: the composition comprises the following raw materials in parts by weight: 50 parts of isomaltooligosaccharide, 20 parts of lactitol, 15 parts of resistant dextrin, 10 parts of fructo-oligosaccharide, 3 parts of inulin, 0.5 part of lactobacillus rhamnosus, 0.3 part of lactobacillus plantarum, 0.3 part of lactobacillus acidophilus, 0.3 part of lactobacillus paracasei, 0.25 part of bifidobacterium bifidum and 0.3 part of stachyose.
Has the advantages that: the probiotic components can optimize the intestinal cavity environment, reestablish microecological balance, improve the level of intestinal cavity immunoglobulin slgA, promote the maturation and development of intestinal mucosa and promote the multi-target inhibition of intestinal inflammation and the proliferation of helicobacter pylori; meanwhile, the prebiotics component is combined, so that the intervention effect is improved;
meanwhile, by adopting the raw materials of the invention, the multi-element polysaccharide can indirectly form a three-dimensional protective layer, so that the flora is protected from being decomposed by strong acid gastric juice, the flora reaches the intestinal tract to be rapidly propagated, and the healthy flora environment of the intestinal tract is maintained.
According to the traditional Chinese medicine view, the probiotic components can be seen as monarch; the intervention effect on gastrointestinal diseases is further enhanced by using medicinal and edible components such as inulin as minister, fructo-oligosaccharide, isomaltooligosaccharide as adjuvant and lactitol as adjuvant.
The invention also provides a preparation method of the instant lactobacillus preparation for regulating gastrointestinal flora, relieving constipation and improving immunity, which comprises the following steps:
(1) pretreatment: pulverizing isomaltooligosaccharide, lactitol, resistant dextrin, fructo-oligosaccharide, inulin and stachyose, and sieving; putting lactobacillus rhamnosus, lactobacillus plantarum, lactobacillus acidophilus, lactobacillus paracasei and bifidobacterium bifidum at 18-26 ℃ for 4 hours for later use;
(2) primary mixing: primarily mixing and stirring the weighed isomaltooligosaccharide, lactitol, resistant dextrin, fructo-oligosaccharide, inulin and stachyose uniformly to obtain a premix and drying the premix for later use;
(3) total mixing: adding lactobacillus rhamnosus, lactobacillus plantarum, lactobacillus acidophilus, lactobacillus paracasei and bifidobacterium bifidum into the premix, uniformly mixing and stirring for the second time to obtain nutrition raw powder, and sealing for later use;
(4) subpackaging: and (5) inspecting, packaging and packaging the nutrient raw powder to obtain a finished product.
Preferably: and (2) sieving by a sieve of 50-80 meshes in the step (1).
Preferably: and (2) drying at the temperature of 45-55 ℃ until the water content of each raw material powder is less than 2%.
Preferably: and (2) primarily mixing and stirring at a rotation speed of 15-20 r/min for 3-10 min.
Preferably: and (3) carrying out secondary mixing and stirring at a rotating speed of 15-20 r/min for 10-20 min.
Preferably: the production environment requires: the humidity is less than 45 percent, and the temperature is less than 28 ℃.
The invention also provides the application of the preparation method in preparing health-care or functional food
The raw powder of the nutritional product can be put into a stainless steel barrel with a clean plastic bag and sealed for storage.
According to the technical scheme, compared with the prior art, the invention discloses and provides the instant lactobacillus preparation for regulating gastrointestinal flora, relieving constipation and improving immunity, and the preparation method has the following technical effects:
(1) experiments show that although the health-care food can not replace medicines, the health-care food has obvious regulating effect on diarrhea, helicobacter pylori infection and gastric ulcer, has the effects of strengthening the spleen and nourishing the stomach, supplementing beneficial flora of gastrointestinal tracts, assisting in medication, obviously preventing and regulating symptoms, maintaining the health of organisms and taking effect quickly.
(2) The components are reasonably matched, have a synergistic interaction effect, and have a better effect compared with the split use.
(3) The selected materials have the characteristics of homology of medicine and food, the components are reasonably matched according to the principle of assistant and guide of the traditional Chinese medicine theory, and the probiotic components are taken as the monarch; better combines various beneficial probiotics discovered by health-care food, the theory of traditional Chinese medicine and modern biology.
(4) Has good stability, good taste and convenient carrying, and is easy to be accepted by patients and insist on drinking.
Detailed Description
The following will clearly and completely describe the technical solutions in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The embodiment of the invention discloses an instant lactobacillus preparation for regulating gastrointestinal flora, relieving constipation and improving immunity.
In the examples, the single bacterial species are purchased from commercial sources such as north sodium organism, and the specific sources thereof are not limited, for example, helicobacter pylori used in the comparative experiment is purchased from north sodium organism, and will not be described herein, and the related single components are purchased from commercial sources and will not be described herein. The related experimental methods are conventional experimental methods, such as helicobacter pylori activation, culture, test paper detection and fluorescent quantitative PCR methods, and can be operated according to instructions or existing documents, or entrusted with professional detection institutions, which are not described in detail.
Example 1
An instant lactobacillus preparation for regulating gastrointestinal flora, relieving constipation and improving immunity comprises the following raw materials in parts by weight: 40 parts of isomaltooligosaccharide, 15 parts of lactitol, 13 parts of resistant dextrin, 8 parts of fructo-oligosaccharide, 1 part of inulin, 0.1 part of lactobacillus rhamnosus, 0.1 part of lactobacillus plantarum, 0.01 part of lactobacillus acidophilus, 0.01 part of lactobacillus paracasei, 0.01 part of bifidobacterium bifidum and 0.01 part of stachyose.
The preparation method comprises the following steps:
(1) pretreatment: pulverizing isomaltooligosaccharide, lactitol, resistant dextrin, fructo-oligosaccharide, inulin and stachyose, and sieving; putting lactobacillus rhamnosus, lactobacillus plantarum, lactobacillus acidophilus, lactobacillus paracasei and bifidobacterium bifidum at 18 ℃ for 4 hours for later use;
(2) primary mixing: primarily mixing and stirring the weighed isomaltooligosaccharide, lactitol, resistant dextrin, fructo-oligosaccharide, inulin and stachyose uniformly to obtain a premix and drying the premix for later use;
(3) total mixing: adding lactobacillus rhamnosus, lactobacillus plantarum, lactobacillus acidophilus, lactobacillus paracasei and bifidobacterium bifidum into the premix, uniformly mixing and stirring for the second time to obtain nutrition raw powder, and sealing for later use;
(4) subpackaging: and (5) inspecting, packaging and packaging the nutrient raw powder to obtain a finished product.
In order to further optimize the technical scheme: and (2) sieving by a 50-mesh sieve in the step (1).
In order to further optimize the technical scheme: and (2) drying at the drying temperature of 45-55 ℃ until the water content of each raw material powder is less than 2%.
In order to further optimize the technical scheme: and (3) carrying out primary uniform mixing and stirring at the rotating speed of 15r/min for 3 min.
In order to further optimize the technical scheme: and (3) carrying out secondary uniform mixing and stirring for 10min at the rotation speed of 15 r/min.
In order to further optimize the technical scheme: the production environment requires: the humidity is less than 45 percent, and the temperature is less than 28 ℃.
Example 2
An instant lactobacillus preparation for regulating gastrointestinal flora, relieving constipation and enhancing immunity is provided. The composition comprises the following raw materials in parts by weight: 50 parts of isomaltooligosaccharide, 20 parts of lactitol, 15 parts of resistant dextrin, 10 parts of fructo-oligosaccharide, 3 parts of inulin, 0.5 part of lactobacillus rhamnosus, 0.3 part of lactobacillus plantarum, 0.3 part of lactobacillus acidophilus, 0.3 part of lactobacillus paracasei, 0.25 part of bifidobacterium bifidum and 0.3 part of stachyose.
The preparation method comprises the following steps:
(1) pretreatment: pulverizing isomaltooligosaccharide, lactitol, resistant dextrin, fructo-oligosaccharide, inulin and stachyose, and sieving; putting lactobacillus rhamnosus, lactobacillus plantarum, lactobacillus acidophilus, lactobacillus paracasei and bifidobacterium bifidum at 20 ℃ for 4 hours for later use;
(2) primary mixing: primarily mixing and stirring the weighed isomaltooligosaccharide, lactitol, resistant dextrin, fructo-oligosaccharide, inulin and stachyose uniformly to obtain a premix and drying the premix for later use;
(3) total mixing: adding lactobacillus rhamnosus, lactobacillus plantarum, lactobacillus acidophilus, lactobacillus paracasei and bifidobacterium bifidum into the premix, uniformly mixing and stirring for the second time to obtain nutrition raw powder, and sealing for later use;
(4) subpackaging: and (5) inspecting, packaging and packaging the nutrient raw powder to obtain a finished product.
In order to further optimize the technical scheme: and (2) sieving by using a 70-mesh sieve in the step (1).
In order to further optimize the technical scheme: and (2) drying at the drying temperature of 50 ℃ until the water content of each raw material powder is less than 2%.
In order to further optimize the technical scheme: and (3) carrying out primary uniform mixing and stirring for 5min at the rotation speed of 18 r/min.
In order to further optimize the technical scheme: and (3) carrying out secondary uniform mixing and stirring at the rotation speed of 18r/min for 15min in the step (2).
In order to further optimize the technical scheme: the production environment requires: the humidity is less than 45 percent, and the temperature is less than 28 ℃.
Example 3
An instant lactobacillus preparation for regulating gastrointestinal flora, relieving constipation and improving immunity comprises the following raw materials in parts by weight: 60 parts of isomaltooligosaccharide, 25 parts of lactitol, 18 parts of resistant dextrin, 12 parts of fructo-oligosaccharide, 5 parts of inulin, 1 part of lactobacillus rhamnosus, 0.6 part of lactobacillus plantarum, 0.6 part of lactobacillus acidophilus, 0.5 part of lactobacillus paracasei, 0.5 part of bifidobacterium bifidum and 0.5 part of stachyose.
The preparation method comprises the following steps:
(1) pretreatment: pulverizing isomaltooligosaccharide, lactitol, resistant dextrin, fructo-oligosaccharide, inulin and stachyose, and sieving; putting lactobacillus rhamnosus, lactobacillus plantarum, lactobacillus acidophilus, lactobacillus paracasei and bifidobacterium bifidum at 26 ℃ for heating for 4 hours for later use;
(2) primary mixing: primarily mixing and stirring the weighed isomaltooligosaccharide, lactitol, resistant dextrin, fructo-oligosaccharide, inulin and stachyose uniformly to obtain a premix and drying the premix for later use;
(3) total mixing: adding lactobacillus rhamnosus, lactobacillus plantarum, lactobacillus acidophilus, lactobacillus paracasei and bifidobacterium bifidum into the premix, uniformly mixing and stirring for the second time to obtain nutrition raw powder, and sealing for later use;
(4) subpackaging: and (5) inspecting, packaging and packaging the nutrient raw powder to obtain a finished product.
In order to further optimize the technical scheme: and (2) sieving by using a 80-mesh sieve in the step (1).
In order to further optimize the technical scheme: and (2) drying at the drying temperature of 55 ℃ until the water content of each raw material powder is less than 2%.
In order to further optimize the technical scheme: and (3) carrying out primary uniform mixing and stirring at the rotating speed of 20r/min for 10min in the step (2).
In order to further optimize the technical scheme: and (3) uniformly mixing and stirring for 20min at the rotation speed of 20r/min for 20min for the second time in the step (2).
In order to further optimize the technical scheme: the production environment requires: the humidity is less than 45 percent, and the temperature is less than 28 ℃.
Comparative experiment 1
In vitro bacteriostasis experiment
Inoculating purchased helicobacter pylori to a solid culture medium, performing conventional culture, and collecting;
centrifuging the collected helicobacter pylori at 2500rpm for 3min, resuspending with liquid culture medium, measuring bacterial concentration, diluting with liquid culture medium containing 10% FBS to 3-4 × 106CFU/ml. 150ul of bacterial liquid and 20ul of bacterial liquid were added to a 96-well plateThe ready-to-eat lactic acid bacteria preparations of examples 1 to 3, each having a final concentration of 1g/ml, were cultured at room temperature for 24 hours, and then subjected to colony counting using agar medium containing 10% sheep blood.
The results show that compared with the blank control (without any bacteriostatic component), the nutritional products provided by the examples 1-3 can inhibit the proliferation of helicobacter pylori in vitro by 52-73%, which indicates that the nutritional products provided by the examples have the function of inhibiting the proliferation of helicobacter pylori in vitro.
Comparative experiment 2
Clinical experiments show that 50 patients (age 45-65 years) suffering from irritable bowel syndrome diarrhea are screened, and the patients are divided into 2 groups at the stage of stopping taking the medicine, and the instant lactobacillus preparation and certain solid beverage (rich in probiotics) which is sold in the market are respectively taken, wherein the solid beverage contains no isomaltooligosaccharide and inulin, and is different from the solid beverage in probiotic matching.
Because the irritable bowel syndrome has complex etiology, a treatment scheme of complete cure and relapse prevention is not available temporarily, after the experiment is carried out for 3 months, the relapse situation is reviewed, and the relapse rate of the instant lactobacillus preparation prepared by the invention is obviously lower than that of the group taking the commercial solid beverage by 70 percent (the group of the invention has 3 relapses for 3 times, and the group of the control group has 10 relapses for 10 times).
The embodiments in the present description are described in a progressive manner, each embodiment focuses on differences from other embodiments, and the same and similar parts among the embodiments are referred to each other.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (9)
1. An instant lactobacillus preparation for regulating gastrointestinal flora, relieving constipation and improving immunity is characterized by comprising the following raw materials in parts by weight: 40-60 parts of isomaltooligosaccharide, 15-25 parts of lactitol, 13-18 parts of resistant dextrin, 8-12 parts of fructo-oligosaccharide, 1-5 parts of inulin, 0.1-1 part of lactobacillus rhamnosus, 0.1-0.6 part of lactobacillus plantarum, 0.01-0.6 part of lactobacillus acidophilus, 0.01-0.5 part of lactobacillus paracasei, 0.01-0.5 part of bifidobacterium bifidum and 0.01-0.5 part of stachyose.
2. The instant lactobacillus preparation for regulating gastrointestinal flora, relieving constipation and improving immunity according to claim 1 is characterized by comprising the following raw materials in parts by weight: 50 parts of isomaltooligosaccharide, 20 parts of lactitol, 15 parts of resistant dextrin, 10 parts of fructo-oligosaccharide, 3 parts of inulin, 0.5 part of lactobacillus rhamnosus, 0.3 part of lactobacillus plantarum, 0.3 part of lactobacillus acidophilus, 0.3 part of lactobacillus paracasei, 0.25 part of bifidobacterium bifidum and 0.3 part of stachyose.
3. The preparation method of the instant lactobacillus preparation for regulating gastrointestinal flora, relieving constipation and improving immunity according to claim 1 or 2, is characterized by comprising the following steps:
(1) pretreatment: pulverizing isomaltooligosaccharide, lactitol, resistant dextrin, fructo-oligosaccharide, inulin and stachyose, and sieving; putting lactobacillus rhamnosus, lactobacillus plantarum, lactobacillus acidophilus, lactobacillus paracasei and bifidobacterium bifidum at 18-26 ℃ for 4 hours for later use;
(2) primary mixing: primarily mixing and stirring the weighed isomaltooligosaccharide, lactitol, resistant dextrin, fructo-oligosaccharide, inulin and stachyose uniformly to obtain a premix and drying the premix for later use;
(3) total mixing: adding lactobacillus rhamnosus, lactobacillus plantarum, lactobacillus acidophilus, lactobacillus paracasei and bifidobacterium bifidum into the premix, uniformly mixing and stirring for the second time to obtain nutrition raw powder, and sealing for later use;
(4) subpackaging: and (5) inspecting, packaging and packaging the nutrient raw powder to obtain a finished product.
4. The preparation method of the instant lactobacillus preparation for regulating gastrointestinal flora, relieving constipation and improving immunity according to claim 3, wherein the sieving in the step (1) is a 50-80 mesh sieve.
5. The preparation method of the instant lactobacillus preparation for regulating gastrointestinal flora, relieving constipation and improving immunity according to claim 4, wherein the drying temperature in the step (1) is 45-55 ℃, and the drying is carried out until the water content of each raw material powder is less than 2%.
6. The preparation method of the instant lactobacillus preparation for regulating gastrointestinal flora, relieving constipation and improving immunity according to claim 5, wherein the preliminary mixing and stirring speed in the step (2) is 15-20 r/min and 3-10 min.
7. The preparation method of the instant lactobacillus preparation for regulating gastrointestinal flora, relieving constipation and improving immunity according to claim 6, wherein the rotation speed of the secondary mixing and stirring in the step (2) is 15-20 r/min and 10-20 min.
8. The preparation method of the instant lactobacillus preparation for regulating gastrointestinal flora, relieving constipation and improving immunity according to any one of claims 3 to 7, wherein the production environment requirements are as follows: the humidity is less than 45 percent, and the temperature is less than 28 ℃.
9. Use of the preparation method according to any one of claims 3 to 8 for the preparation of a health or functional food.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110761722.9A CN113455650A (en) | 2021-07-06 | 2021-07-06 | Instant lactobacillus preparation for regulating gastrointestinal flora, relieving constipation and improving immunity |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110761722.9A CN113455650A (en) | 2021-07-06 | 2021-07-06 | Instant lactobacillus preparation for regulating gastrointestinal flora, relieving constipation and improving immunity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113455650A true CN113455650A (en) | 2021-10-01 |
Family
ID=77878492
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110761722.9A Pending CN113455650A (en) | 2021-07-06 | 2021-07-06 | Instant lactobacillus preparation for regulating gastrointestinal flora, relieving constipation and improving immunity |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113455650A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114504110A (en) * | 2022-02-16 | 2022-05-17 | 河南磐康健康管理股份有限公司 | Composition for regulating and improving intestinal dysbacteriosis and preparation method thereof |
| CN115011516A (en) * | 2022-06-13 | 2022-09-06 | 东北农业大学 | Synbiotic yoghourt with constipation relieving effect and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108741090A (en) * | 2018-08-28 | 2018-11-06 | 安徽谷益生物科技有限公司 | A kind of compound probiotic functional food inhibiting helicobacter pylori |
| CN109329419A (en) * | 2018-08-28 | 2019-02-15 | 吉林标普生物科技有限公司 | A kind of functional probiotics solid beverage and preparation method thereof for being able to maintain that intestinal health and improving immunity |
| CN109464487A (en) * | 2018-11-28 | 2019-03-15 | 吉林禾未来功能产品有限公司 | Probiotics compound of anti-helicobacter pylori and preparation method thereof |
-
2021
- 2021-07-06 CN CN202110761722.9A patent/CN113455650A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108741090A (en) * | 2018-08-28 | 2018-11-06 | 安徽谷益生物科技有限公司 | A kind of compound probiotic functional food inhibiting helicobacter pylori |
| CN109329419A (en) * | 2018-08-28 | 2019-02-15 | 吉林标普生物科技有限公司 | A kind of functional probiotics solid beverage and preparation method thereof for being able to maintain that intestinal health and improving immunity |
| CN109464487A (en) * | 2018-11-28 | 2019-03-15 | 吉林禾未来功能产品有限公司 | Probiotics compound of anti-helicobacter pylori and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114504110A (en) * | 2022-02-16 | 2022-05-17 | 河南磐康健康管理股份有限公司 | Composition for regulating and improving intestinal dysbacteriosis and preparation method thereof |
| CN115011516A (en) * | 2022-06-13 | 2022-09-06 | 东北农业大学 | Synbiotic yoghourt with constipation relieving effect and preparation method thereof |
| CN115011516B (en) * | 2022-06-13 | 2023-11-14 | 东北农业大学 | Synbiotic yogurt with constipation relieving effect and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP4163276B2 (en) | Functional composition | |
| Guan et al. | Influence of probiotic fermented fruit and vegetables on human health and the related industrial development trend | |
| CN102318806B (en) | Preparation method of probiotics fermented pumpkin and carrot vegetable powder | |
| CN113455650A (en) | Instant lactobacillus preparation for regulating gastrointestinal flora, relieving constipation and improving immunity | |
| CN106578064B (en) | Donkey-hide gelatin and lactic acid bacteria beverage and preparation method thereof | |
| CN110903995B (en) | Probiotic edible composition and food with digestion promoting effect | |
| CN111671079A (en) | Composite probiotic powder composition and preparation method thereof | |
| CN111935995A (en) | Nutritional composition, and food and drink composition and formulated milk powder using the same | |
| CN112155056B (en) | Yoghourt for adjusting intestinal tract and preparation method and application thereof | |
| CN114921363A (en) | Composite probiotics for inhibiting fat accumulation and application thereof | |
| CN113142304A (en) | Probiotic composition for promoting human body metabolism to generate yellow feces and application thereof | |
| CN112544721A (en) | Milk tablet for promoting growth of vital essence and preparation method thereof | |
| Astashkina et al. | Microbiological quality control of probiotic products | |
| CN108402454B (en) | Red-core pitaya enzyme, preparation method and application thereof | |
| CN106617095B (en) | Donkey-hide gelatin probiotic oral liquid and preparation method thereof | |
| CN112616932A (en) | Goat milk tablet for protecting oral health and preparation method thereof | |
| Sherwani | Probiotics in processed dairy products and their role in gut microbiota health | |
| CN113397170B (en) | Application of marine prebiotics composition for regulating human intestinal flora | |
| Panesar et al. | Probiotics, prebiotics and synbiotics: opportunities, health benefits and industrial challenges | |
| CN114984065A (en) | Probiotic composition for improving immunity and preparation method thereof | |
| Song et al. | Microencapsulation of endophytic LAB (KCC-41) and its probiotic and fermentative potential for cabbage kimchi | |
| CN110839693B (en) | Application of parabacteroides gibsonii in preventing or treating obesity or related diseases | |
| CN110897166B (en) | Edible composition containing probiotics and casein phosphopeptide with digestion promoting effect | |
| CN116076729A (en) | Composition, and food and medicine containing the same | |
| KR102004204B1 (en) | lactic acid bacteria improved stability and preparing method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20211001 |