CN113440470A - 一种有效缓解熬夜皮肤不适感的组合物其制备方法与用途 - Google Patents
一种有效缓解熬夜皮肤不适感的组合物其制备方法与用途 Download PDFInfo
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Abstract
本发明公开了一种有效缓解熬夜皮肤不适感的组合物及制备方法与用途，该组合物包含：水、丁二醇、甘油、硅烷二醇水杨酸酯、β‑葡聚糖、丹参根提取物、丁香花蕾提取物、黄芩根提取物、当归根提取物、甘草根提取物、积雪草提取物、甲基丙二醇、碳酸丙二醇酯、1,3‑丙二醇、乳酸杆菌发酵溶胞产物、辛基十二醇、广藿香叶提取物、PEG‑40氢化蓖麻油、精氨酸、丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物、丙烯酸酯类/C10‑30烷醇丙烯酸酯交联聚合物、透明质酸钠、可可提取物等。本发明还提供了该组合物的制备方法与用途。本发明制备的组合物能够针对性解决熬夜引起的皮肤不适感，并能促进皮肤修复、保湿、抗菌及抗炎功能等。
Description
技术领域
本发明涉及一种用于化妆品领域的缓解熬夜不适感的组合物及其制备方法和应用，具体地，涉及一种有效缓解熬夜皮肤不适感的组合物其制备方法与用途。
背景技术
随着社会内卷现象的不断加重，当代年轻人熬夜情况也越来越普遍。经常熬夜会造成的很多不良症状，首先人体的免疫力也会跟着下降，会出现炎症和过敏等等自律神经失调症状都会出现。其次熬夜会导致过度疲劳，造成眼睛周围的血液循环不良，引起黑眼圈、眼袋或是白眼球布满血丝。晚上11时到第二天凌晨3时是美容时间，也是人体的身体器官休息的时间段(其中包括肝、胆)。这身体器官如果没有获得充分的休息，就会表现在皮肤上，容易出现粗糙、脸色偏黄、长黑斑和青春痘等问题。而且，更糟糕的是，长期熬夜会慢慢地出现失眠、健忘、易怒、焦虑不安等神经、精神症状。由于熬夜引起的皮肤不适感的复杂性和多样性，目前无可以有效缓解应熬夜而导致的各种不同的不适感的产品。
发明内容
本发明的目的是提供一种适用于所有肤质的缓解熬夜不适感的组合物及其制备和在护肤品中的应用，能够解决现有问题，针对熬夜引起的皮肤不适感，并能促进皮肤修复、保湿、抗菌及抗炎功能等。
为了达到上述目的，本发明提供了一种有效缓解熬夜皮肤不适感的组合物，其中，该组合物包含A相、B相、C相、D相；A相包含水、丁二醇、甘油、硅烷二醇水杨酸酯、β-葡聚糖、丹参根提取物、丁香花蕾提取物、黄芩根提取物、当归根提取物、甘草根提取物、积雪草提取物、甲基丙二醇、碳酸丙二醇酯、1,3-丙二醇、乳酸杆菌发酵溶胞产物、辛基十二醇；B相包含广藿香叶提取物、PEG-40氢化蓖麻油、精氨酸、丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物、丙烯酸酯类/C10-30烷醇丙烯酸酯交联聚合物、透明质酸钠、可可提取物、糊精；C相包含o-伞花烃-5-醇、苯氧乙醇、辛酰羟肟酸；D相包含1,2-己二醇、对羟基苯乙酮、甘草酸二钾、EDTA二钠。
上述的有效缓解熬夜皮肤不适感的组合物，其中，所述的组合物中按重量份数计包含：丁二醇4～6份、甘油0.5～1.5份、硅烷二醇水杨酸酯2～4份、β-葡聚糖0.5～1.5份、丹参根提取物0.5～1.5份、丁香花蕾提取物0.5～1.5份、黄芩根提取物0.5～1.5份、当归根提取物0.5～1.5份、甘草根提取物0.5～1.5份、积雪草提取物0.5～1.5份、甲基丙二醇1～2份、碳酸丙二醇酯1～2份、1,3-丙二醇1～3份、乳酸杆菌发酵溶胞产物4～6份、辛基十二醇1～3份、广藿香叶提取物2～4份、PEG-40氢化蓖麻油2～4份、精氨酸0.4～0.6份、丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物0.5～1.5份、丙烯酸酯类/C10-30烷醇丙烯酸酯交联聚合物0.4～0.6份、透明质酸钠0.5～1.5份、可可提取物4～6份、糊精0.2～0.4份、o-伞花烃-5-醇0.2～0.4份、苯氧乙醇0.03～0.06份、辛酰羟肟酸0.4～0.6份、1,2-己二醇0.5～1.5份、对羟基苯乙酮0.4～0.6份、甘草酸二钾0.4～0.6份、EDTA二钠0.04～0.07份。
上述的有效缓解熬夜皮肤不适感的组合物，其中，所述的组合物中按质量百分比计包含：丁二醇5％、甘油1％、硅烷二醇水杨酸酯3％、β-葡聚糖1％、丹参根提取物1％、丁香花蕾提取物1％、黄芩根提取物1％、当归根提取物1％、甘草根提取物1％、积雪草提取物1％、甲基丙二醇1.5％、碳酸丙二醇酯1.5％、1,3-丙二醇2％、乳酸杆菌发酵溶胞产物5％、辛基十二醇2％、广藿香叶提取物3％、PEG-40氢化蓖麻油3％、精氨酸0.5％、丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物1％、丙烯酸酯类/C10-30烷醇丙烯酸酯交联聚合物0.5％、透明质酸钠1％、可可提取物5％、糊精0.3％、o-伞花烃-5-醇0.3％、苯氧乙醇0.05％、辛酰羟肟酸0.5％、1,2-己二醇1％、对羟基苯乙酮0.5％、甘草酸二钾0.5％、EDTA二钠0.05％。
上述的有效缓解熬夜皮肤不适感的组合物，其中，所述的组合物中按质量百分比计加水到100％。
本发明还提供了一种上述的有效缓解熬夜皮肤不适感的组合物的制备方法，其中，所述的方法包含：步骤1、按比例称量各原料，并分为A相、B相、C相、D相；步骤2、将A相、B相分别加热，并各自混合均匀；步骤3、在搅拌条件下将B相加入A相，乳化均匀；步骤4、再加入C相，继续乳化均匀；步骤5、乳化完成后，搅拌冷却；步骤6、最后加入D相，搅拌均匀即可。
上述的有效缓解熬夜皮肤不适感的组合物的制备方法，其中，所述的步骤2中，将A相、B相分别加热至75℃。
上述的有效缓解熬夜皮肤不适感的组合物的制备方法，其中，所述的步骤3中，将B相加入A相，以8000转/分钟的转速乳化2-3分钟。
上述的有效缓解熬夜皮肤不适感的组合物的制备方法，其中，所述的步骤4中，加入C相，以8000转/分钟的转速继续乳化2-3分钟。
上述的有效缓解熬夜皮肤不适感的组合物的制备方法，其中，所述的步骤5中，乳化完成后，慢速搅拌冷却至40℃。
本发明也提供了上述的方法制备的有效缓解熬夜皮肤不适感的组合物的用途，其中，该组合物用于制备护肤品；该护肤品包含敷贴面膜。
本发明提供的有效缓解熬夜皮肤不适感的组合物其制备方法与用途具有以下优点：
本发明专利涉及的有效缓解熬夜皮肤不适感的组合物首次将硅烷二醇水杨酸酯、β-葡聚糖、透明质酸钠、乳酸杆菌发酵溶胞产物、可可(THEOBROMA CACAO)提取物以及多种植物中药提取物(丹参、丁香、黄芩、当归、甘草、积雪草等)进行组合，适用于各种由于熬夜引起的皮肤不适，在快速修复皮肤的同时，可以形成天然皮肤屏障，保湿锁水，抗炎抑菌等功能，从而改善敏感性肌肤，从而保持皮肤的水润与健康。
该组合物可以快速缓解由于熬夜产生的皮肤各种不适感，缓解验证反应，同时具有超强的保湿能力，可以在形成天然的皮肤屏障，保湿锁水，抗炎抑菌。
具体实施方式
以下对本发明的具体实施方式作进一步地说明。
本发明提供的有效缓解熬夜皮肤不适感的组合物，包含A相、B相、C相、D相；A相包含水、丁二醇、甘油、硅烷二醇水杨酸酯、β-葡聚糖、丹参根提取物、丁香花蕾提取物、黄芩根提取物、当归根提取物、甘草根提取物、积雪草提取物、甲基丙二醇、碳酸丙二醇酯、1,3-丙二醇、乳酸杆菌发酵溶胞产物、辛基十二醇；B相包含广藿香叶提取物、PEG-40氢化蓖麻油、精氨酸、丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物、丙烯酸酯类/C10-30烷醇丙烯酸酯交联聚合物、透明质酸钠、可可提取物、糊精；C相包含o-伞花烃-5-醇、苯氧乙醇、辛酰羟肟酸；D相包含1,2-己二醇、对羟基苯乙酮、甘草酸二钾、EDTA二钠。
优选地，该组合物中按重量份数计包含：丁二醇4～6份、甘油0.5～1.5份、硅烷二醇水杨酸酯2～4份、β-葡聚糖0.5～1.5份、丹参根提取物0.5～1.5份、丁香花蕾提取物0.5～1.5份、黄芩根提取物0.5～1.5份、当归根提取物0.5～1.5份、甘草根提取物0.5～1.5份、积雪草提取物0.5～1.5份、甲基丙二醇1～2份、碳酸丙二醇酯1～2份、1,3-丙二醇1～3份、乳酸杆菌发酵溶胞产物4～6份、辛基十二醇1～3份、广藿香叶提取物2～4份、PEG-40氢化蓖麻油2～4份、精氨酸0.4～0.6份、丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物0.5～1.5份、丙烯酸酯类/C10-30烷醇丙烯酸酯交联聚合物0.4～0.6份、透明质酸钠0.5～1.5份、可可提取物4～6份、糊精0.2～0.4份、o-伞花烃-5-醇0.2～0.4份、苯氧乙醇0.03～0.06份、辛酰羟肟酸0.4～0.6份、1,2-己二醇0.5～1.5份、对羟基苯乙酮0.4～0.6份、甘草酸二钾0.4～0.6份、EDTA二钠0.04～0.07份。
更优选地，该组合物中按质量百分比计包含：丁二醇5％、甘油1％、硅烷二醇水杨酸酯3％、β-葡聚糖1％、丹参根提取物1％、丁香花蕾提取物1％、黄芩根提取物1％、当归根提取物1％、甘草根提取物1％、积雪草提取物1％、甲基丙二醇1.5％、碳酸丙二醇酯1.5％、1,3-丙二醇2％、乳酸杆菌发酵溶胞产物5％、辛基十二醇2％、广藿香叶提取物3％、PEG-40氢化蓖麻油3％、精氨酸0.5％、丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物1％、丙烯酸酯类/C10-30烷醇丙烯酸酯交联聚合物0.5％、透明质酸钠1％、可可提取物5％、糊精0.3％、o-伞花烃-5-醇0.3％、苯氧乙醇0.05％、辛酰羟肟酸0.5％、1,2-己二醇1％、对羟基苯乙酮0.5％、甘草酸二钾0.5％、EDTA二钠0.05％。
该组合物中按质量百分比计加水到100％。
本发明中的组合物主要功能成分有：硅烷二醇水杨酸酯、β-葡聚糖、透明质酸钠、乳酸杆菌发酵溶胞产物、可可(THEOBROMA CACAO)提取物以及植物提取物(丹参(SALVIAMILTIORRHIZA)根提取物、丁香(EUGENIA CARYOPHYLLUS)花蕾提取物、黄芩(SCUTELLARIABAICALENSIS)根提取物、甘草根提取物、当归(ANGELICA POLYMORPHA SINENSIS)根提取物、积雪草(CENTELLA ASIATICA)提取物)
硅烷二醇水杨酸酯属于水杨酸类的衍生物。为皮肤提供油脂，减少表皮水分蒸发，同时降低皮肤中白介素IL(促进炎症反应)水平，减少炎症(包括紫外线UV介导的炎症)，清除自由基，抑制脂质过氧化，保护皮肤内细胞、蛋白以及酶等，能够刺激皮肤的胶原蛋白和弹性蛋白纤维数量增长，密度提高，同时能消除自由基，具有抗氧性；改善和促进角质细胞和成纤维细胞间的交流，从而激活细胞功能；同时具有舒缓抗敏的功效，具有细胞屏障功能。
β-葡聚糖，来源于巴西蘑菇，含天然β-葡聚糖。能够活化巨噬细胞、嗜中性白血球等，促进合成细胞因子(IL-1)，提高白细胞素、细胞分裂素和特殊抗体的含量，全面刺激机体的免疫系统，抵御病原微生物入侵；促进细胞生长、促进伤口愈合和增强免疫系统方面有更强的功效。从而有效的增加皮肤的免疫能力，预防病原微生物的感染。
多种透明质酸钠复合物可以组成人体皮肤真皮层，在皮肤表面形成保湿透气膜，阻隔外界物质(病原微生物、UC等物质)对皮肤的刺激，减少病原微生物的入侵；可以进入真皮层，促进血液循环，滋养细胞及细胞器官，促进皮肤对营养成分的吸收与利用。所以透明质酸钠可以有效的缓解熬夜使皮肤产生的各种不适感。
乳酸杆菌发酵溶胞产物是一种由戊糖乳杆菌发酵而来的溶胞产物。其能有效地促进细胞周期素B1和增殖细胞核抗原的表达，加快细胞增殖，促进伤口愈合。其能恢复表皮屏障功能，修复红血丝、敏感肌，达到抗衰老的作用,达到补水保湿、抗敏、修复敏感肌等作用。
可可(THEOBROMA CACAO)提取物具有很好的渗透性，能够快速有效的滋养皮肤。其能促进皮肤新陈代谢，结合其抗氧化性，具有抗衰的作用；抑制组胺的释放，具有抗敏舒缓的作用；对金属蛋白酶有抑制作用，说明具有抗炎性。其中可可粉，维生素，能够促进血液循环，去除皮肤老化和多余的角质，改善色素沉淀肌肤，增加皮肤弹性和胶原蛋白。可可脂的熔点为37℃，接近人体温度，在肌肤温度的作用下能渗透入肌肤深处，将水分牢牢锁住，且保持肌肤畅通的呼吸。
丹参(SALVIA MILTIORRHIZA)根提取物中具有抗炎和抗菌能力，抑制皮脂腺细胞增生和缩小皮脂腺细胞体积作用，起到保湿作用，有助于皮肤的修复。
黄岑根提取物抑制皮肤的炎症反应，具有极强地广谱性抑菌作用，可以极速缓解由于熬夜而引起的各类炎症反应，还可以增强皮肤抗敏能力。
当归根提取物可以控制血管皮细胞的扩张，具有改善熬夜后皮肤的作用；其良好的SOD样活性，可以抑制过氧化反应和自由基反应，与磷脂结合，保护生物膜，具有极强修复能力。
甘草根提取物可以促进肌细胞和血管内皮细胞的增殖，促进胶原带白的生成，抑制NO的生成，增强皮肤免疫力，抗发炎及降低氧化速度，能改善对肌肤敏感的现象，安抚舒缓熬夜后不适的皮肤。
积雪草提取物为植物胶原蛋白，具有消肿解毒祛脓疮的作用；同时其可以促进皮肤胶原蛋白再生，增强细胞基底层细胞活力，调节皮肤免疫力。
本发明还提供了该有效缓解熬夜皮肤不适感的组合物的制备方法，包含：步骤1、按比例称量各原料，并分为A相、B相、C相、D相；步骤2、将A相、B相分别加热，并各自混合均匀；步骤3、在搅拌条件下将B相加入A相，乳化均匀；步骤4、再加入C相，继续乳化均匀；步骤5、乳化完成后，搅拌冷却；步骤6、最后加入D相，搅拌均匀即可。
步骤2中，将A相、B相分别加热至75℃。
步骤3中，将B相加入A相，以8000转/分钟的转速乳化2-3分钟。
步骤4中，加入C相，以8000转/分钟的转速继续乳化2-3分钟。
步骤5中，乳化完成后，慢速搅拌冷却至40℃。
本发明也提供了该方法制备的有效缓解熬夜皮肤不适感的组合物的用途，该组合物用于制备护肤品；该护肤品包含敷贴面膜。
下面结合实施例对本发明提供的有效缓解熬夜皮肤不适感的组合物其制备方法与用途做更进一步描述。
实施例1
一种有效缓解熬夜皮肤不适感的组合物，成分如下表1所示。各原料分别符合相应的国家标准。
表1.组合物配料表(按质量百分比计)。
本实施例还提供了该有效缓解熬夜皮肤不适感的组合物的制备方法，包含：
步骤1、按比例称量各原料，并分为A相、B相、C相、D相。
步骤2、将A相、B相分别加热至75℃，并各自混合均匀。
步骤3、在搅拌条件下将B相加入A相，以8000转/分钟的转速乳化2-3分钟，使其乳化均匀。
步骤4、再加入C相，以8000转/分钟的转速继续乳化2-3分钟，使其乳化均匀。
步骤5、乳化完成后，慢速搅拌冷却至40℃。
步骤6、最后加入D相，搅拌均匀即可。
本实施例也提供了该方法制备的有效缓解熬夜皮肤不适感的组合物的用途，该组合物用于制备护肤品；该护肤品包含敷贴面膜。
实施例2
一种有效缓解熬夜皮肤不适感的组合物，按重量份数计包含：
丁二醇4份、甘油0.5份、硅烷二醇水杨酸酯2份、β-葡聚糖0.5份、丹参根提取物0.5份、丁香花蕾提取物0.5份、黄芩根提取物0.5份、当归根提取物0.5份、甘草根提取物0.5份、积雪草提取物0.5份、甲基丙二醇1份、碳酸丙二醇酯1份、1,3-丙二醇1份、乳酸杆菌发酵溶胞产物4份、辛基十二醇1份、广藿香叶提取物2份、PEG-40氢化蓖麻油2份、精氨酸0.4份、丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物0.5份、丙烯酸酯类/C10-30烷醇丙烯酸酯交联聚合物0.4份、透明质酸钠0.5份、可可提取物4份、糊精0.2份、o-伞花烃-5-醇0.2份、苯氧乙醇0.03份、辛酰羟肟酸0.4份、1,2-己二醇0.5份、对羟基苯乙酮0.4份、甘草酸二钾0.4份、EDTA二钠0.04份。
最后将该组合物按重量份数计加水到100份。
本实施例还提供了该有效缓解熬夜皮肤不适感的组合物的制备方法，包含：
步骤1、按比例称量各原料，并分为A相、B相、C相、D相。
步骤2、将A相、B相分别加热至75℃，并各自混合均匀。
步骤3、在搅拌条件下将B相加入A相，以8000转/分钟的转速乳化2-3分钟，使其乳化均匀。
步骤4、再加入C相，以8000转/分钟的转速继续乳化2-3分钟，使其乳化均匀。
步骤5、乳化完成后，慢速搅拌冷却至40℃。
步骤6、最后加入D相，搅拌均匀即可。
本实施例也提供了该方法制备的有效缓解熬夜皮肤不适感的组合物的用途，该组合物用于制备护肤品；该护肤品包含敷贴面膜。
实施例3
一种有效缓解熬夜皮肤不适感的组合物，按重量份数计包含：
丁二醇6份、甘油1.5份、硅烷二醇水杨酸酯4份、β-葡聚糖1.5份、丹参根提取物1.5份、丁香花蕾提取物1.5份、黄芩根提取物1.5份、当归根提取物1.5份、甘草根提取物1.5份、积雪草提取物1.5份、甲基丙二醇2份、碳酸丙二醇酯2份、1,3-丙二醇3份、乳酸杆菌发酵溶胞产物6份、辛基十二醇3份、广藿香叶提取物4份、PEG-40氢化蓖麻油4份、精氨酸0.6份、丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物1.5份、丙烯酸酯类/C10-30烷醇丙烯酸酯交联聚合物0.6份、透明质酸钠1.5份、可可提取物6份、糊精0.4份、o-伞花烃-5-醇0.4份、苯氧乙醇0.06份、辛酰羟肟酸0.6份、1,2-己二醇1.5份、对羟基苯乙酮0.6份、甘草酸二钾0.6份、EDTA二钠0.07份。
最后将该组合物按重量份数计加水到100份。
本实施例还提供了该有效缓解熬夜皮肤不适感的组合物的制备方法，包含：
步骤1、按比例称量各原料，并分为A相、B相、C相、D相。
步骤2、将A相、B相分别加热至75℃，并各自混合均匀。
步骤3、在搅拌条件下将B相加入A相，以8000转/分钟的转速乳化2-3分钟，使其乳化均匀。
步骤4、再加入C相，以8000转/分钟的转速继续乳化2-3分钟，使其乳化均匀。
步骤5、乳化完成后，慢速搅拌冷却至40℃。
步骤6、最后加入D相，搅拌均匀即可。
本实施例也提供了该方法制备的有效缓解熬夜皮肤不适感的组合物的用途，该组合物用于制备护肤品；该护肤品包含敷贴面膜。
采用各实施例制备的组合物进行测试及评估，具体方式如下。
1.实验对象
实验组(本发明)：30例，男15例，女15例；年龄10-42岁；
对照组(安慰剂-普通保湿液)：30例，男15例，女15例，年龄12-50岁。
两组人员的性别、年龄等资料经统计学处理，差异无统计学意义(P>0.05)，两组有可比性。
2.治疗方式，对实验组脸部涂抹本发明，对照组脸部涂抹普通保湿液，记录肌肤修复时间并作如下评估，记录不适反应的发生。
3.评估标准：
根据皮肤干燥、发痒、暗沉、浮肿、发红、刺痛和出油情况进行评价。
痊愈：症状及体征消退95％以上。
显效：临床表现减轻80％-94％。
好转：临表现减轻50％-79％。
无效：临床表现无改善。
复发：再次出现上述临床表现。
4.结果：结果如下表2所示。
表2.测试结果表。
对实验组与对照组进行差异性分析(P＜0.05)有显著差异，具有统计学意义。实验组有效率明显高于对照组有效率，说明实验组可以快速缓解由于熬夜而带来的皮肤不适感，而且在15个小时内不会产生各种不适感，同时实验组未产生不适发生，说明该发明具有良好效果。
本发明采用的成分中，硅烷二醇水杨酸酯为皮肤提供油脂，减少表皮水分蒸发，减少炎症；抑制脂质过氧化，消除自由基，改善和促进角质细胞和成纤维细胞的形成，激活细胞功能；具有舒缓抗敏的功效和细胞屏障功能。β-葡聚糖能够促进细胞生长、促进伤口愈合和增强免疫系统方面有更强的功效。多种透明质酸钠复合物在皮肤表面形成保湿透气膜，阻隔外界物质对皮肤的刺激，减少病原微生物的入侵；促进血液循环，滋养细胞及细胞器官，促进皮肤对营养成分的吸收与利用。乳酸杆菌发酵溶胞产物能有效地促进细胞周期素B1和增殖细胞核抗原的表达，加快细胞增殖，促进伤口愈合。恢复表皮屏障功能，修复红血丝、敏感肌，达到抗衰老的作用,达到补水保湿、抗敏、修复敏感肌等作用。可可提取物能够快速有效的滋养皮肤，促进皮肤新陈代谢，具有抗衰的作用；抑制组胺的释放，具有抗敏舒缓的作用；对金属蛋白酶有抑制作用，具有抗炎性。
本发明提供的有效缓解熬夜皮肤不适感的组合物其制备方法与用途，具有修复皮肤屏障，保湿锁水，抗炎抑菌等功能，可以达到快速修护敏感肌肤、淡化色斑效果，从而保持皮肤的水润与健康，消除由于熬夜而带来的皮肤困扰。
尽管本发明的内容已经通过上述优选实施例作了详细介绍，但应当认识到上述的描述不应被认为是对本发明的限制。在本领域技术人员阅读了上述内容后，对于本发明的多种修改和替代都将是显而易见的。因此，本发明的保护范围应由所附的权利要求来限定。
Claims (10)
1.一种有效缓解熬夜皮肤不适感的组合物，其特征在于，该组合物包含A相、B相、C相、D相；
A相包含水、丁二醇、甘油、硅烷二醇水杨酸酯、β-葡聚糖、丹参根提取物、丁香花蕾提取物、黄芩根提取物、当归根提取物、甘草根提取物、积雪草提取物、甲基丙二醇、碳酸丙二醇酯、1,3-丙二醇、乳酸杆菌发酵溶胞产物、辛基十二醇；
B相包含广藿香叶提取物、PEG-40氢化蓖麻油、精氨酸、丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物、丙烯酸酯类/C10-30烷醇丙烯酸酯交联聚合物、透明质酸钠、可可提取物、糊精；
C相包含o-伞花烃-5-醇、苯氧乙醇、辛酰羟肟酸；
D相包含1,2-己二醇、对羟基苯乙酮、甘草酸二钾、EDTA二钠。
2.如权利要求1所述的有效缓解熬夜皮肤不适感的组合物，其特征在于，所述的组合物中按重量份数计包含：丁二醇4～6份、甘油0.5～1.5份、硅烷二醇水杨酸酯2～4份、β-葡聚糖0.5～1.5份、丹参根提取物0.5～1.5份、丁香花蕾提取物0.5～1.5份、黄芩根提取物0.5～1.5份、当归根提取物0.5～1.5份、甘草根提取物0.5～1.5份、积雪草提取物0.5～1.5份、甲基丙二醇1～2份、碳酸丙二醇酯1～2份、1,3-丙二醇1～3份、乳酸杆菌发酵溶胞产物4～6份、辛基十二醇1～3份、广藿香叶提取物2～4份、PEG-40氢化蓖麻油2～4份、精氨酸0.4～0.6份、丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物0.5～1.5份、丙烯酸酯类/C10-30烷醇丙烯酸酯交联聚合物0.4～0.6份、透明质酸钠0.5～1.5份、可可提取物4～6份、糊精0.2～0.4份、o-伞花烃-5-醇0.2～0.4份、苯氧乙醇0.03～0.06份、辛酰羟肟酸0.4～0.6份、1,2-己二醇0.5～1.5份、对羟基苯乙酮0.4～0.6份、甘草酸二钾0.4～0.6份、EDTA二钠0.04～0.07份。
3.如权利要求2所述的有效缓解熬夜皮肤不适感的组合物，其特征在于，所述的组合物中按质量百分比计包含：丁二醇5％、甘油1％、硅烷二醇水杨酸酯3％、β-葡聚糖1％、丹参根提取物1％、丁香花蕾提取物1％、黄芩根提取物1％、当归根提取物1％、甘草根提取物1％、积雪草提取物1％、甲基丙二醇1.5％、碳酸丙二醇酯1.5％、1,3-丙二醇2％、乳酸杆菌发酵溶胞产物5％、辛基十二醇2％、广藿香叶提取物3％、PEG-40氢化蓖麻油3％、精氨酸0.5％、丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物1％、丙烯酸酯类/C10-30烷醇丙烯酸酯交联聚合物0.5％、透明质酸钠1％、可可提取物5％、糊精0.3％、o-伞花烃-5-醇0.3％、苯氧乙醇0.05％、辛酰羟肟酸0.5％、1,2-己二醇1％、对羟基苯乙酮0.5％、甘草酸二钾0.5％、EDTA二钠0.05％。
4.如权利要求3所述的有效缓解熬夜皮肤不适感的组合物，其特征在于，所述的组合物中按质量百分比计加水到100％。
5.一种如权利要求1～4中任意一项所述的有效缓解熬夜皮肤不适感的组合物的制备方法，其特征在于，所述的方法包含：
步骤1、按比例称量各原料，并分为A相、B相、C相、D相；
步骤2、将A相、B相分别加热，并各自混合均匀；
步骤3、在搅拌条件下将B相加入A相，乳化均匀；
步骤4、再加入C相，继续乳化均匀；
步骤5、乳化完成后，搅拌冷却；
步骤6、最后加入D相，搅拌均匀即可。
6.如权利要求5所述的有效缓解熬夜皮肤不适感的组合物的制备方法，其特征在于，所述的步骤2中，将A相、B相分别加热至75℃。
7.如权利要求5所述的有效缓解熬夜皮肤不适感的组合物的制备方法，其特征在于，所述的步骤3中，将B相加入A相，以8000转/分钟的转速乳化2-3分钟。
8.如权利要求5所述的有效缓解熬夜皮肤不适感的组合物的制备方法，其特征在于，所述的步骤4中，加入C相，以8000转/分钟的转速继续乳化2-3分钟。
9.如权利要求5所述的有效缓解熬夜皮肤不适感的组合物的制备方法，其特征在于，所述的步骤5中，乳化完成后，慢速搅拌冷却至40℃。
10.一种如权利要求5所述的方法制备的有效缓解熬夜皮肤不适感的组合物的用途，其特征在于，所述的组合物用于制备护肤品；所述的护肤品包含敷贴面膜。
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