CN113436776A - Directional moving method for droplet carrier type micro object - Google Patents
Directional moving method for droplet carrier type micro object Download PDFInfo
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- CN113436776A CN113436776A CN202110567963.XA CN202110567963A CN113436776A CN 113436776 A CN113436776 A CN 113436776A CN 202110567963 A CN202110567963 A CN 202110567963A CN 113436776 A CN113436776 A CN 113436776A
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- flat plate
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- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21K—TECHNIQUES FOR HANDLING PARTICLES OR IONISING RADIATION NOT OTHERWISE PROVIDED FOR; IRRADIATION DEVICES; GAMMA RAY OR X-RAY MICROSCOPES
- G21K1/00—Arrangements for handling particles or ionising radiation, e.g. focusing or moderating
Abstract
The invention provides a directional moving method of a drop carrier type micro object, which comprises the following steps: s1, placing a tiny object on a flat plate; s2, adding liquid drops on the tiny objects, wherein the liquid drops wrap the tiny objects and are not infiltrated into the flat plate; s3, guiding the liquid drops wrapping the tiny objects to directionally move to a target position on the flat plate; s4, evaporating the liquid drops, and enabling the tiny objects to stand still at the target positions. The invention adopts a simpler operation method, can effectively push the micro objects to directionally move on the flat plate, does not need precise and complicated operation instruments, and has good economic performance.
Description
Technical Field
The invention relates to the technical field of directional movement of tiny objects, in particular to a droplet carrier type directional movement method of tiny objects.
Background
The directional movement is an important mode for material separation and material processing, and has wide application in the fields of biology, materials, electronics and the like. At present, the technology for realizing the directional movement of the tiny objects mainly utilizes a tool to carry out accurate grabbing. The following modes are available for accurate grabbing: (1) magnetic materials such as iron, cobalt, nickel and the like are mixed on the tiny objects, and the tiny objects are transferred by utilizing the electromagnetic attraction and release modes. (2) When the micro objects need to be placed at a designated position, the other silicon electrode is electrified with negative electricity, and the purpose of transferring can be finished. Chinese patent publication No. CN108807213A, published as 7/14/2020, discloses a method for transferring a micro-device. A carrier substrate provided with a plurality of first electrodes and a plurality of minute elements is provided. The micro-components are separated from each other and are electrically connected with the first electrodes respectively. The receiving substrate and the carrier substrate are relatively close. The receiving substrate is provided with a plurality of second electrodes, and the second electrodes are opposite to the first electrodes in electrical property. A first voltage and a second voltage are applied to two first electrodes partially adjacent to each other, so that the minute element is released from the carrier substrate to the receiving substrate and bonded to the receiving substrate. (3) The tiny objects are grabbed through the air pressure difference generated by the vacuum suction nozzle, and then the tiny objects are placed through vacuum removal, so that the tiny objects are transferred (4) by using an elastic die, a printing head is controlled by combining high-precision motion, and the tiny objects are adhered to the transfer head and printed to a specified position by changing the speed of the printing head through Van der Waals force. The moving mode of the micro objects is complex to operate, and a precise instrument is needed for matching, so that the cost is high.
Disclosure of Invention
The invention aims to overcome the defects that the existing directional moving method of the tiny object is complex to operate and needs high-cost precision instruments to be matched, and provides a liquid drop carrier type directional moving method of the tiny object. The invention adopts a simpler operation method, can effectively push the micro objects to directionally move on the flat plate, does not need precise and complex instruments, and has good economic performance.
In order to solve the technical problems, the invention adopts the technical scheme that: a method for directionally moving a droplet carrier type micro object comprises the following steps:
s1, placing a tiny object on a flat plate;
s2, adding liquid drops on the tiny objects, wherein the liquid drops wrap the tiny objects and are not infiltrated into the flat plate;
s3, guiding the liquid drops wrapping the tiny objects to directionally move to a target position on the flat plate;
s4, evaporating the liquid drops, and enabling the tiny objects to stand still at the target positions.
In the technical scheme, the tiny objects are wrapped by the liquid drops on the flat plate, the liquid drops cannot be infiltrated with the flat plate, the liquid drops can drive the tiny objects to move on the flat plate under the guidance of an external force, and the moving direction and distance of the liquid drops on the flat plate can be controlled by controlling the direction and the size of the external force, so that the liquid drops wrapping the tiny objects can directionally move on the flat plate and reach the target position on the flat plate.
Further, the flat plate in step S1 is made of an insulating material, and in step S2, the liquid droplets are charged; in step S3, an electrostatic field is applied in a direction perpendicular to the plate, and the electrostatic field directs the charged droplets to move directionally on the plate to the target location.
Further, in step S3, one or more movable ultrasonic heads are connected to the flat plate, the liquid drop is located at the resonant node position, and the ultrasonic head position and frequency are adjusted to change the node position, so as to guide the liquid drop to directionally move on the flat plate to the target position.
Further, a surfactant is added into the liquid drops, and the surfactant is azo organic matter. Azo organic compounds have a molecular structure of the form R-N-R', and generate free radicals under heat or light, and the surface energy of the radicals changes.
Preferably, a nonionic surfactant is added into the liquid drop, and the nonionic surfactant is selected from nonionic polyacrylamide. In the case of light or heat, the solubility changes, thereby affecting its surface energy. The change in surface energy affects the surface tension of the droplet.
Further, in step S3, an array-type heating device is disposed below the flat plate to generate a temperature gradient on the surface of the flat plate, the temperature gradient on the flat plate changes the surface tension of the liquid droplet, and the liquid droplet is directionally moved to a target position on the flat plate.
Further, in step S3, the side of the droplet is irradiated with laser, the droplet undergoes local temperature rise or local evaporation, the local tension of the droplet is changed, and the droplet is directionally moved to the target position on the flat plate.
Further, in step S4, the flat plate is heated by the heating device until the droplets on the surface are completely evaporated.
Preferably, in step S4, the droplet is heated by the laser until it is completely evaporated.
Compared with the prior art, the invention has the beneficial effects that:
the invention adopts liquid drops which are not soaked with the flat plate to wrap tiny objects on the flat plate, so that the tiny objects are suspended in the liquid drops, and then the liquid drops are controlled by external force to move directionally on the flat plate until the liquid drops wrapping the tiny objects move to a target position on the flat plate; the invention can generate external force to push the liquid drop through a plurality of modes, such as laser irradiation, ultrasonic drive, electrostatic field drive and temperature gradient generated by the array type heating device on the flat plate, can effectively push the liquid drop to directionally move on the flat plate, does not need precise and complicated instruments, and has good economic performance.
Drawings
FIG. 1 is a flow chart of the present invention.
FIG. 2 is a schematic diagram of the process of moving a droplet on a plate in example 4.
The graphic symbols are illustrated as follows:
1. laser; 2. a droplet; 3. micro objects; 4. and (4) flat plate.
Detailed Description
The present invention will be further described with reference to the following embodiments. Wherein the showings are for the purpose of illustration only and are shown by way of illustration only and not in actual form, and are not to be construed as limiting the present patent; to better illustrate the embodiments of the present invention, some parts of the drawings may be omitted, enlarged or reduced, and do not represent the size of an actual product; it will be understood by those skilled in the art that certain well-known structures in the drawings and descriptions thereof may be omitted.
The same or similar reference numerals in the drawings of the embodiments of the present invention correspond to the same or similar components; in the description of the present invention, it should be understood that if there is an orientation or positional relationship indicated by the terms "upper", "lower", "left", "right", etc. based on the orientation or positional relationship shown in the drawings, it is only for convenience of describing the present invention and simplifying the description, but it is not intended to indicate or imply that the referred device or element must have a specific orientation, be constructed in a specific orientation, and be operated, and therefore, the terms describing the positional relationship in the drawings are only used for illustrative purposes and are not to be construed as limiting the present patent, and the specific meaning of the terms may be understood by those skilled in the art according to specific circumstances.
Example 1
FIG. 1 shows an embodiment of the present invention of a method for directionally moving a droplet 2 carrier-type fine object 3. The method comprises the following specific steps:
s1, placing a tiny object 3 on a flat plate 4;
s2, adding the liquid drops 2 on the tiny objects 3, wherein the tiny objects 3 are wrapped by the liquid drops 2, and the liquid drops 2 are not soaked with the flat plate 4;
s3, guiding the liquid drops 2 wrapping the tiny objects 3 to directionally move to a target position on the flat plate 4;
s4, evaporating the liquid drops 2, and enabling the micro objects 3 to be stationary at the target positions.
In this embodiment, the droplet 2 includes the fine object 3, and under the driving of the external force, the droplet 2 drives the fine object 3 to directionally move on the flat plate 4 until the droplet 2 drives the fine object 3 to move to the target position on the flat plate 4.
Example 2
This embodiment is similar to embodiment 1 except that the plate 4 is made of an insulating material, the droplets 2 are charged, and the charged droplets 2 do not wet the plate 4. Applying an electrostatic field in a direction perpendicular to the plate 4, and directionally moving the charged liquid drop 2 under the guidance of the electrostatic field until the liquid drop moves to a target position on the plate 4; the electrostatic field is turned off, the laser 1 irradiates vertically the middle position of the top of the liquid drop 2, and the liquid drop 2 is continuously heated until the liquid drop is completely evaporated, and only the tiny objects 3 are left at the target position on the flat plate 4.
Example 3
The embodiment is similar to the embodiment 1, and is different in that a flat plate 4 is placed on a platform capable of controlling the inclination angle and the direction, a liquid drop 2 wraps a tiny object 3 on the flat plate 4, a worker controls the inclination angle and the direction of the platform to drive the flat plate 4 on the platform to incline together, the liquid drop 2 is not soaked with the flat plate 4, the liquid drop 2 can drive the tiny object 3 to move on the flat plate 4, the platform is adjusted to be in a horizontal state after the tiny object reaches a target position, a laser 1 vertically irradiates the middle position of the top of the liquid drop 2, the liquid drop 2 is continuously heated until the liquid drop is completely evaporated, and only the tiny object 3 is left at the target position on the flat plate 4.
Example 4
This example is similar to example 1, except that the surfactant is added to the liquid droplet 2, and the surfactant is azo organic compound having a molecular structure of R-N-R' form, which can generate radical species under the condition of light or heat, and the surface energy is changed. As shown in fig. 2, after a liquid drop 2 is added on a flat plate 4, the liquid drop 2 wraps a tiny object 3, and laser 1 is emitted into one side of the liquid drop 2 to change the surface energy of the side, so that the surface tension of the side is changed, and the liquid drop 2 moves; continuing to directionally move the laser 1 in a manner of irradiating the side edge until the liquid drop 2 is directionally moved to a specified position on the flat plate 4; the laser 1 irradiates vertically the middle position of the top of the liquid drop 2, and continuously heats the liquid drop 2 until the liquid drop is completely evaporated, and only a tiny object 3 is left at the target position on the flat plate 4.
Example 5
This example is similar to example 1, except that a nonionic surfactant, which is nonionic polyacrylamide, is added to the droplets 2, and the surface tension thereof is changed by heating. An array type heating device is arranged at the bottom of the flat plate 4, so that a temperature gradient is generated on the surface of the flat plate 4, the surface tension of the liquid drop 2 is changed, and the liquid drop 2 is directionally moved to a target position according to the change of the surface tension. And starting the array type heating device to integrally heat the flat plate 4, generating no temperature gradient, evaporating the liquid drops 2 on the flat plate 4, and only remaining tiny objects 3 stay at the target position.
Example 6
This embodiment is similar to embodiment 1, except that a plurality of movable ultrasonic heads are installed on the flat plate 4, the liquid drop 2 on the flat plate 4 is at the resonant node position, and the position and frequency of the ultrasonic heads are adjusted to change the node position, so as to drive the liquid drop 2 to directionally move to the target position. The laser 1 irradiates vertically the middle position of the top of the liquid drop 2, and continuously heats the liquid drop 2 until the liquid drop is completely evaporated, and only a tiny object 3 is left at the target position on the flat plate 4.
It should be understood that the above-described embodiments of the present invention are merely examples for clearly illustrating the present invention, and are not intended to limit the embodiments of the present invention. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. Any modification, equivalent replacement, and improvement made within the spirit and principle of the present invention should be included in the protection scope of the claims of the present invention.
Claims (10)
1. A method for directionally moving a droplet carrier type micro object is characterized in that: the method comprises the following steps:
s1, placing a tiny object on a flat plate;
s2, adding liquid drops on the tiny objects, wherein the liquid drops wrap the tiny objects and are not infiltrated into the flat plate;
s3, guiding the liquid drops wrapping the tiny objects to directionally move to a target position on the flat plate;
s4, evaporating the liquid drops, and enabling the tiny objects to stand still at the target positions.
2. The method of claim 1, wherein the droplet carrier type micro-objects are moved in a directional manner: the plate in step S1 is made of an insulating material, and the droplets are charged in step S2.
3. The method of claim 2, wherein the droplet carrier type micro-objects are moved in a direction of the liquid droplet carrier type micro-objects: in step S3, an electrostatic field is applied in a direction perpendicular to the plate, and the electrostatic field directs the charged droplets to move directionally on the plate to the target location.
4. The method of claim 1, wherein the droplet carrier type micro-objects are moved in a directional manner: in step S3, one or more movable ultrasonic heads are connected to the plate, the liquid drop is located at the resonant node position, and the position and frequency of the ultrasonic head are adjusted to change the node position, so as to guide the liquid drop to move directionally on the plate to the target position.
5. The method of claim 1, wherein the droplet carrier type micro-objects are moved in a directional manner: and adding a surfactant into the liquid drops, wherein the surfactant is an azo organic matter.
6. The method of claim 1, wherein the droplet carrier type micro-objects are moved in a directional manner: and adding a nonionic surfactant into the liquid drops, wherein the nonionic surfactant is selected from nonionic polyacrylamide.
7. The method of claim 5 or 6, wherein the droplet carrier type micro-objects are moved in a directional manner: in step S3, an array heating device is disposed below the flat plate to generate a temperature gradient on the surface of the flat plate, the temperature gradient on the flat plate changes the surface tension of the liquid droplet, and the liquid droplet moves directionally on the flat plate to a target position.
8. The method of claim 5 or 6, wherein the droplet carrier type micro-objects are moved in a directional manner: in step S3, the side of the droplet is irradiated with laser light, the droplet undergoes local temperature rise or local evaporation, the local tension of the droplet is changed, and the droplet is directionally moved to a target position on the flat plate.
9. The method of claim 1, wherein the droplet carrier type micro-objects are moved in a directional manner: in step S4, the flat plate is heated by the heating device until the droplets on the surface thereof are completely evaporated.
10. The method of claim 1, wherein the droplet carrier type micro-objects are moved in a directional manner: in step S4, the droplet is heated by the laser until it is completely evaporated.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202110567963.XA CN113436776A (en) | 2021-05-24 | 2021-05-24 | Directional moving method for droplet carrier type micro object |
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| CN202110567963.XA CN113436776A (en) | 2021-05-24 | 2021-05-24 | Directional moving method for droplet carrier type micro object |
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Citations (8)
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| JPH10327590A (en) * | 1997-05-22 | 1998-12-08 | Yoshikazu Matsui | Surface acoustic wave actuator |
| US20050037507A1 (en) * | 2001-12-28 | 2005-02-17 | Christoph Gauer | Titration method |
| CN1729561A (en) * | 2002-12-18 | 2006-02-01 | 皇家飞利浦电子股份有限公司 | Manipulation object using small liquid |
| US20060105549A1 (en) * | 2002-12-18 | 2006-05-18 | Duineveld Paulus C | Manipulation of micrometer-sized electronic objects with liquid droplets |
| JP2008090066A (en) * | 2006-10-03 | 2008-04-17 | Tama Tlo Kk | Micro object handling device, its handling method, micro object transporting device and its transporting method |
| JP2012032258A (en) * | 2010-07-30 | 2012-02-16 | Osaka City Univ | Droplet moving device and droplet moving method |
| US20120157346A1 (en) * | 1996-04-25 | 2012-06-21 | Bioarray Solutions, Ltd. | Programmable illumination pattern for transporting microparticles |
| CN109865485A (en) * | 2019-03-06 | 2019-06-11 | 广东工业大学 | A kind of displacement method of small items |
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2021
- 2021-05-24 CN CN202110567963.XA patent/CN113436776A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120157346A1 (en) * | 1996-04-25 | 2012-06-21 | Bioarray Solutions, Ltd. | Programmable illumination pattern for transporting microparticles |
| JPH10327590A (en) * | 1997-05-22 | 1998-12-08 | Yoshikazu Matsui | Surface acoustic wave actuator |
| US20050037507A1 (en) * | 2001-12-28 | 2005-02-17 | Christoph Gauer | Titration method |
| CN1729561A (en) * | 2002-12-18 | 2006-02-01 | 皇家飞利浦电子股份有限公司 | Manipulation object using small liquid |
| US20060105549A1 (en) * | 2002-12-18 | 2006-05-18 | Duineveld Paulus C | Manipulation of micrometer-sized electronic objects with liquid droplets |
| JP2008090066A (en) * | 2006-10-03 | 2008-04-17 | Tama Tlo Kk | Micro object handling device, its handling method, micro object transporting device and its transporting method |
| JP2012032258A (en) * | 2010-07-30 | 2012-02-16 | Osaka City Univ | Droplet moving device and droplet moving method |
| CN109865485A (en) * | 2019-03-06 | 2019-06-11 | 广东工业大学 | A kind of displacement method of small items |
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