CN113397703A - Manufacturing method of personalized support for bone defect part and personalized support for bone defect part - Google Patents
Manufacturing method of personalized support for bone defect part and personalized support for bone defect part Download PDFInfo
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- CN113397703A CN113397703A CN202110689706.3A CN202110689706A CN113397703A CN 113397703 A CN113397703 A CN 113397703A CN 202110689706 A CN202110689706 A CN 202110689706A CN 113397703 A CN113397703 A CN 113397703A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
- A61B34/10—Computer-aided planning, simulation or modelling of surgical operations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
- A61B34/10—Computer-aided planning, simulation or modelling of surgical operations
- A61B2034/101—Computer-aided simulation of surgical operations
- A61B2034/105—Modelling of the patient, e.g. for ligaments or bones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2/30942—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
- A61F2002/30948—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques using computerized tomography, i.e. CT scans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2002/30985—Designing or manufacturing processes using three dimensional printing [3DP]
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- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Vascular Medicine (AREA)
- Prostheses (AREA)
Abstract
The invention relates to the technical field of medical instruments, and particularly discloses a method for manufacturing a personalized support for a bone defect part and a personalized support for the bone defect part, wherein the method for manufacturing the personalized support for the bone defect part comprises the following steps: establishing a bone defect peripheral part solid model; establishing a bone defect part preliminary solid model on a bone defect peripheral part solid model according to a healthy side bone structure; cutting a primary solid model of the bone defect part; dividing a bone-like tissue fiber structure of the preliminary solid model of the bone defect part; creating a plurality of connector solid models according to the appearance of the peripheral part of the bone defect; fitting and designing the bone defect part solid model and the plurality of connector solid models to obtain a bone defect part personalized support model; and manufacturing the individualized support of the bone defect part by a rapid prototyping manufacturing process according to the fitting data. The scaffold solves the problem that the bone substitute implantation can not meet the requirements of form and mechanics on repair, resulting in shorter service life cycle.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to a method for manufacturing a bone defect part personalized support and the bone defect part personalized support.
Background
At present, there are two main methods for repairing bone defect sites, namely autologous free bone implantation and bone substitute implantation. The autologous free bone transplantation has the advantages of strong autologous bone induction osteogenesis capacity and high fusion rate, but the bone taking needs additional incision, the postoperative bone taking area can be painful for a long time, secondary damage is caused to a patient, in addition, the source is less, and the requirement of mass bone implantation cannot be met. Although there is no need to worry about the amount of the bone substitute for bone substitute implantation, the bone substitute implantation cannot meet the requirements of morphological and mechanical repair, and the service life cycle is short because it is easy for the prosthesis to loosen, shift, fall off or break at the initial stage.
Disclosure of Invention
The invention aims to: the method for manufacturing the individualized support at the bone defect part and the individualized support at the bone defect part are provided to solve the problems that the implantation of the bone substitute in the related technology can not meet the requirements of shape and mechanics for repair, and the service life cycle is short because the condition that the repair body is loosened, displaced, dropped or broken easily occurs at the initial stage.
On one hand, the invention provides a method for manufacturing a personalized bracket for a bone defect part, which comprises the following steps:
establishing a bone defect peripheral part entity model of a patient;
establishing a bone defect part preliminary solid model on a bone defect peripheral part solid model by referring to analysis of a healthy lateral bone structure;
cutting a primary solid model of the bone defect part;
carrying out bone-like tissue fiber structure division on the preliminary solid model of the bone defect part, and further obtaining the solid model of the bone defect part with bone tissue characteristics and mechanical gradient characteristics;
creating a plurality of connector solid models according to the appearance of the bone defect peripheral part;
fitting and designing the bone defect part solid model and the plurality of connector solid models to obtain a bone defect part personalized support model;
and manufacturing the individualized support of the bone defect part by a rapid forming manufacturing process according to the data of the individualized support model of the bone defect part obtained by fitting.
As a preferred technical scheme of the manufacturing method of the individualized bracket at the bone defect part, the step of establishing the solid model of the bone defect peripheral part of the patient comprises the following steps:
performing CT scanning on the bone defect peripheral part of the patient;
and modeling by using CT scanning data through three-dimensional modeling software.
As an optimal technical scheme of the manufacturing method of the individualized bracket at the bone defect part, the step of dividing the fiber structure of the preliminary solid model at the bone defect part comprises the following steps:
carrying out mesh division on the preliminary solid model of the bone defect part;
and optimizing and adjusting the wire diameter, the pore diameter, the porosity and the connectivity of the grid according to the anatomical and microstructure mechanical characteristics of the bone.
As the preferable technical scheme of the manufacturing method of the individualized bracket at the bone defect part, the solid model of the connecting body is provided with a through hole.
As the preferable technical scheme of the manufacturing method of the individualized scaffold at the bone defect position, the fitting design is Boolean summation operation.
As the preferred technical scheme of the manufacturing method of the individualized scaffold at the bone defect part, the rapid prototyping manufacturing process is a 3D printing manufacturing process.
As a preferable technical scheme of the manufacturing method of the personalized scaffold at the bone defect position, the personalized scaffold at the bone defect position is made of metal titanium.
On the other hand, the invention provides a bone defect part personalized bracket which is manufactured by adopting the bone defect part personalized bracket manufacturing method in any scheme, the bone defect part personalized bracket comprises a bone defect part entity and a plurality of connecting bodies, the plurality of connecting bodies are fixedly connected with the bone defect part entity, the bone defect part entity is matched with the bone defect part of a patient, and the plurality of connecting bodies are respectively fixedly connected with the bone defect peripheral part.
As a preferred technical scheme of the personalized support for the bone defect part, the bone defect part entity is of a truss structure.
As a preferred technical scheme of the individualized bracket at the bone defect part, a grid structure is arranged on the surface of the connecting body opposite to the peripheral part of the bone defect.
The invention has the beneficial effects that:
the invention provides a method for manufacturing a personalized bracket for a bone defect part, which comprises the following steps: establishing a bone defect peripheral part entity model of a patient; establishing a bone defect part preliminary solid model on a bone defect peripheral part solid model by referring to analysis of a healthy lateral bone structure; cutting a primary solid model of the bone defect part; carrying out bone-like tissue fiber structure division on the preliminary solid model of the bone defect part, and further obtaining the solid model of the bone defect part with bone tissue characteristics and mechanical gradient characteristics; creating a plurality of connector solid models according to the appearance of the peripheral part of the bone defect; fitting and designing the bone defect part solid model and the plurality of connector solid models to obtain a bone defect part personalized support model; and manufacturing the individualized support of the bone defect part by a rapid molding manufacturing process according to the data of the individualized support model of the bone defect part obtained by fitting. In the process of manufacturing the individualized support of the bone defect part, firstly establishing a solid model of the bone defect periphery part of a patient, then referring to the bone structure on one healthy side and establishing a preliminary solid model of the bone defect part on the basis of the established solid model of the bone defect periphery part, wherein the established preliminary solid model of the bone defect part is perfectly matched with the solid model of the bone defect periphery part, then cutting out the preliminary solid model of the bone defect part, carrying out bone-like tissue fiber structure division on the preliminary solid model of the bone defect part to obtain the solid model of the bone defect part, so that the solid model of the bone defect part has bone tissue characteristics and mechanical gradient characteristics, arranging a plurality of solid models of connectors on the solid model of the bone defect part, wherein the solid models of the connectors have the same appearance as that of the solid model of the bone defect part corresponding to the solid model of the bone periphery part, and then obtaining the individualized support model of the, finally, the individual support at the bone defect part can be manufactured by a rapid forming manufacturing technology, and the support solves the problems that the implantation of the bone substitute can not meet the requirements of shape and mechanics for repair, and the service life cycle is short because the condition that the repair body is loosened, displaced, dropped or broken easily occurs at the initial stage.
Drawings
FIG. 1 is a flow chart of a method for manufacturing a personalized scaffold at a bone defect site according to an embodiment of the invention;
FIG. 2 is a schematic diagram of a preliminary solid model of a bone defect site according to the method for manufacturing a personalized scaffold for a bone defect site in an embodiment of the present invention;
FIG. 3 is a solid model diagram of a bone defect site of the personalized scaffold for bone defect site according to the embodiment of the present invention;
FIG. 4 is a solid model diagram of a connecting body for a method of manufacturing a personalized scaffold for a bone defect site according to an embodiment of the present invention;
FIG. 5 is a model diagram of a personalized scaffold for a bone defect site according to the method for manufacturing the personalized scaffold for a bone defect site in the embodiment of the present invention;
FIG. 6 is a schematic structural diagram of a personalized scaffold at a bone defect site according to an embodiment of the invention;
fig. 7 is a partial enlarged view of the lattice structure at a position a of the personalized scaffold at a bone defect site in the embodiment of the invention.
In the figure:
100. a solid model of the bone defect peripheral part;
1. a preliminary solid model of a bone defect site; 2. a bone defect site solid model; 3. a connector solid model; 4. a personalized scaffold model at a bone defect site;
5. personalized scaffolds for bone defect sites; 51. a bone defect site entity; 52. a linker; 521. and (4) grid body structure.
Detailed Description
The technical solutions of the present invention will be described clearly and completely with reference to the accompanying drawings, and it should be understood that the described embodiments are some, but not all embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc., indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplicity of description, but do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first," "second," and the like are used for descriptive purposes only and are not to be construed as indicating or implying relative importance. Where the terms "first position" and "second position" are two different positions, and where a first feature is "over", "above" and "on" a second feature, it is intended that the first feature is directly over and obliquely above the second feature, or simply means that the first feature is at a higher level than the second feature. A first feature being "under," "below," and "beneath" a second feature includes the first feature being directly under and obliquely below the second feature, or simply meaning that the first feature is at a lesser elevation than the second feature.
In the description of the present invention, it should be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.
Reference will now be made in detail to embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the accompanying drawings are illustrative only for the purpose of explaining the present invention, and are not to be construed as limiting the present invention.
As shown in fig. 1 to 5, the present embodiment provides a method for manufacturing a personalized scaffold for a bone defect site, which includes the following steps:
s100: a solid model 100 of the patient at the site surrounding the bone defect is established.
S200: referring to the analysis of the healthy lateral bone structure, a bone defect part preliminary solid model 1 is established on the bone defect peripheral part solid model 100.
S300: and (3) cutting out a primary solid model 1 of the bone defect part.
In this embodiment, steps S100, S200, and S300 are processes of building the preliminary solid model 1 of the bone defect portion, and the purpose of steps S100 and S200 is to perfectly fit the built preliminary solid model 1 of the bone defect portion with the solid model 100 of the bone defect peripheral portion, so as to realize that the shape of the preliminary solid model 1 of the bone defect portion is the same as that of the bone defect portion, thereby avoiding the occurrence of the loosening, displacement, or even falling-off of the prosthesis.
S400: and carrying out bone-like tissue fiber structure division on the preliminary solid model 1 of the bone defect part, and further obtaining a solid model 2 of the bone defect part.
In this embodiment, the purpose of dividing the fibrous structure of the bone-like tissue is to make the primary solid model 1 of the bone defect portion have bone tissue characteristics and mechanical gradient characteristics by changing the internal structure, and finally obtain the solid model 2 of the bone defect portion.
S500: a plurality of solid connected body models 3 are created according to the appearance of the peripheral part of the bone defect. In this embodiment, the solid model 3 of the connector is further provided with a through hole, the connector 52 obtained by the solid model 3 of the connector is provided with a through hole, and a screw is inserted into the through hole of the connector 52 and is screwed with the bone defect periphery
S600: and fitting and designing the bone defect part solid model 2 and the plurality of connector solid models 3 to further obtain a bone defect part personalized support model 4.
In this embodiment, the purpose of steps S500 and S600 is to obtain the personalized scaffold model 4 for a bone defect site, wherein the solid connector model 3 and the solid bone defect peripheral site model 100 opposite to the solid connector model 3 are seamlessly attached. Preferably, the fitting is designed as a boolean summation operation.
S700: and manufacturing the individualized support 5 of the bone defect part by a rapid forming manufacturing process according to the data of the individualized support model 4 of the bone defect part obtained by fitting. Preferably, the rapid prototyping manufacturing process is a 3D printing manufacturing process, and the bone defect site personalized scaffold 5 is made of a titanium metal material.
Optionally, the step of establishing a physical model 100 of the patient at the site surrounding the bone defect comprises:
s101: and carrying out CT scanning on the bone defect peripheral part of the patient.
S101: and modeling by using CT scanning data through three-dimensional modeling software.
In the embodiment, the data obtained by CT scanning is used for modeling, and the model established by the data is convenient, time-saving and more accurate.
Optionally, the step of dividing the fiber structure of the preliminary solid model 1 of the bone defect site includes:
carrying out mesh division on the bone defect part preliminary solid model 1;
and optimizing and adjusting the wire diameter, the pore diameter, the porosity and the connectivity of the grid according to the anatomy of the bone and the mechanical characteristics of the microstructure.
In this embodiment, the interior of the preliminary solid model 1 of the bone defect portion is changed into a truss structure through fiber structure division, in this embodiment, the truss structure is formed by combining a plurality of tetrahedral frames, and in other embodiments, the truss structure may be formed by other different kinds of frame structures. In this embodiment, the wire diameter is 0.1-2mm, the porosity is 40-95%, and the pore diameter is 0.2-10mm, and the above parameters are selected according to the actual conditions according to the difference of different bone parts and individual constitutions.
Optionally, the solid model 3 is attached to the bone defect periphery and screwed by screws. In this embodiment, the screw is made of a biocompatible metal material, and specifically, the screw is made of a titanium metal material.
On the other hand, as shown in fig. 6 to 7, the present embodiment further provides a bone defect site personalized scaffold, which is manufactured by the bone defect site personalized scaffold manufacturing method in any of the above embodiments, the bone defect site personalized scaffold 5 includes a bone defect site entity 51 and a plurality of connecting bodies 52, the plurality of connecting bodies 52 are fixedly connected with the bone defect site entity 51, the bone defect site entity 51 is fitted with the bone defect site of the patient, and the plurality of connecting bodies 52 are respectively fixedly connected with the bone defect peripheral site. In this embodiment, after the bone defect portion entity 51 is perfectly fitted to the bone defect portion, the plurality of connectors 52 are attached to the bone defect peripheral portion, and then screws are attached to the bone defect peripheral portion through the connectors 52.
Optionally, bone defect site entity 51 is a truss structure. In this embodiment, the truss structure is formed by combining a plurality of tetrahedral frames, and in other embodiments, the truss structure may be formed by other different kinds of frame structures. Because the bone at the bone defect part can automatically heal, the bone at the defect part can extend into the truss to grow in the healing process, thereby avoiding the loosening, the displacement and even the shedding of the solid body 51 at the bone defect part, and simultaneously, the weight of the solid body 51 at the bone defect part can be reduced by designing the solid body 51 at the bone defect part into a truss structure.
Optionally, a mesh structure 521 is provided on the surface of the connecting body 52 facing the bone defect periphery. In this embodiment, the connecting body 52 is attached to the bone defect periphery, and the grid structure 521 provided on the surface of the connecting body 52 is advantageous for the bone length of the bone defect periphery, such as in the grid structure 521, and is advantageous for improving the stability of the connection between the connecting body 52 and the bone defect periphery.
It should be understood that the above-described embodiments of the present invention are merely examples for clearly illustrating the present invention, and are not intended to limit the embodiments of the present invention. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. Any modification, equivalent replacement, and improvement made within the spirit and principle of the present invention should be included in the protection scope of the claims of the present invention.
Claims (10)
1. A manufacturing method of a personalized bracket at a bone defect part is characterized by comprising the following steps:
establishing a solid model (100) of a bone defect peripheral part of a patient;
establishing a bone defect part preliminary solid model (1) on a bone defect peripheral part solid model (100) by referring to analysis of a healthy side bone structure;
cutting a primary solid model (1) of a bone defect part;
carrying out bone-like tissue fiber structure division on the preliminary solid model (1) of the bone defect part, and further obtaining a solid model (2) of the bone defect part with bone tissue characteristics and mechanical gradient characteristics;
creating a plurality of connector solid models (3) according to the appearance of the bone defect peripheral part;
fitting and designing the bone defect part solid model (2) and the plurality of connector solid models (3) to further obtain a bone defect part personalized support model (4);
and manufacturing the individualized support (5) at the bone defect part by a rapid forming manufacturing process according to the data of the individualized support model (4) at the bone defect part obtained by fitting.
2. The method for manufacturing the personalized scaffold at the bone defect site according to claim 1, wherein the step of establishing a solid model (100) of the bone defect peripheral site of the patient comprises:
performing CT scanning on the bone defect peripheral part of the patient;
and modeling by using CT scanning data through three-dimensional modeling software.
3. The method for manufacturing the personalized scaffold at the bone defect site according to claim 1, wherein the step of dividing the fiber structure of the preliminary solid model (1) at the bone defect site comprises the following steps:
carrying out mesh division on the bone defect part preliminary solid model (1);
and optimizing and adjusting the wire diameter, the pore diameter, the porosity and the connectivity of the grid according to the anatomical and microstructure mechanical characteristics of the bone.
4. The method for manufacturing the personalized scaffold at the bone defect site according to claim 1, characterized in that the solid model (3) of the connecting body is provided with a through hole.
5. The method for manufacturing the personalized scaffold at the bone defect site according to claim 1, wherein the fitting design is a Boolean summation operation.
6. The method for manufacturing the personalized scaffold at the bone defect part according to claim 1, wherein the rapid prototyping manufacturing process is a 3D printing manufacturing process.
7. The method for manufacturing the personalized scaffold for a bone defect site according to claim 1, wherein the personalized scaffold for a bone defect site (5) is made of metallic titanium.
8. A bone defect site individual support manufactured by the bone defect site individual support manufacturing method according to any one of claims 1 to 7, characterized in that the bone defect site individual support (5) comprises a bone defect site entity (51) and a plurality of connecting bodies (52), the plurality of connecting bodies (52) are fixedly connected with the bone defect site entity (51), the bone defect site entity (51) is matched with a bone defect site of a patient, and the plurality of connecting bodies (52) are respectively fixedly connected with a bone defect peripheral site.
9. The bone defect site personalized scaffold according to claim 8, characterized in that the bone defect site entity (51) is a truss structure.
10. The personalized scaffold for a bone defect site according to claim 8, wherein the face of the connecting body (52) opposite to the bone defect peripheral site is provided with a mesh structure (521).
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- 2021-06-22 CN CN202110689706.3A patent/CN113397703B/en active Active
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| EP3284441A1 (en) * | 2016-08-15 | 2018-02-21 | Technische Universität Dresden | Transplant for removing a bone defect on the jaw and method of manufacturing the transplant |
| CN208611050U (en) * | 2018-01-25 | 2019-03-19 | 北京中安泰华科技有限公司 | A kind of personalization truss structure fusion device |
| CN109091273A (en) * | 2018-06-13 | 2018-12-28 | 西安交通大学 | A kind of personalized pelvis endoprosthesis designs method based on topological structure optimization |
| CN109276352A (en) * | 2018-09-17 | 2019-01-29 | 上海交通大学医学院附属第九人民医院 | A kind of integrated molding metal pelvis jointing repair prosthesis of 3D printing individuation and preparation method thereof |
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